PSPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.65667155
2DNA strand elongation (GO:0022616)4.47060835
3telomere maintenance via semi-conservative replication (GO:0032201)4.46857064
4DNA replication initiation (GO:0006270)4.39757124
5DNA deamination (GO:0045006)4.35949546
6ribosomal small subunit assembly (GO:0000028)4.23732868
7proteasome assembly (GO:0043248)4.16186204
8L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.94672503
9telomere maintenance via recombination (GO:0000722)3.93904155
10water-soluble vitamin biosynthetic process (GO:0042364)3.92399027
11* L-serine metabolic process (GO:0006563)3.86300397
12formation of translation preinitiation complex (GO:0001731)3.82824925
13ribosomal small subunit biogenesis (GO:0042274)3.80630993
14nucleobase biosynthetic process (GO:0046112)3.80292712
15nucleotide-excision repair, DNA gap filling (GO:0006297)3.72128756
16chaperone-mediated protein transport (GO:0072321)3.67115062
17transcription-coupled nucleotide-excision repair (GO:0006283)3.63239005
18establishment of integrated proviral latency (GO:0075713)3.59479026
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57574796
20IMP biosynthetic process (GO:0006188)3.56823371
21cullin deneddylation (GO:0010388)3.55437191
22purine nucleobase biosynthetic process (GO:0009113)3.55056041
23mitotic recombination (GO:0006312)3.54800135
24termination of RNA polymerase III transcription (GO:0006386)3.54714419
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.54714419
26DNA unwinding involved in DNA replication (GO:0006268)3.48498644
27telomere maintenance via telomere lengthening (GO:0010833)3.46018159
28protein deneddylation (GO:0000338)3.45389837
29CENP-A containing nucleosome assembly (GO:0034080)3.43286539
30maturation of SSU-rRNA (GO:0030490)3.43050811
31ribonucleoprotein complex biogenesis (GO:0022613)3.43029392
32ribosomal large subunit biogenesis (GO:0042273)3.41443778
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40303552
347-methylguanosine mRNA capping (GO:0006370)3.38815560
35termination of RNA polymerase I transcription (GO:0006363)3.37467492
367-methylguanosine RNA capping (GO:0009452)3.34225483
37RNA capping (GO:0036260)3.34225483
38ribosome biogenesis (GO:0042254)3.33280859
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.33229769
40negative regulation of ligase activity (GO:0051352)3.32087551
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32087551
42DNA replication checkpoint (GO:0000076)3.32085711
43viral transcription (GO:0019083)3.32022841
44chromatin remodeling at centromere (GO:0031055)3.31465634
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28678070
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28251021
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27302651
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.27203561
49translational termination (GO:0006415)3.26733254
50rRNA processing (GO:0006364)3.26504382
51spliceosomal snRNP assembly (GO:0000387)3.26492666
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25978145
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23460657
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23460657
55IMP metabolic process (GO:0046040)3.22707200
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20437684
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20437684
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20437684
59regulation of mitochondrial translation (GO:0070129)3.19759776
60ATP synthesis coupled proton transport (GO:0015986)3.19665769
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19665769
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19268833
63transcription from RNA polymerase I promoter (GO:0006360)3.18731293
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.16250381
65NADH dehydrogenase complex assembly (GO:0010257)3.16250381
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16250381
67viral mRNA export from host cell nucleus (GO:0046784)3.15684492
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15463907
69protein complex biogenesis (GO:0070271)3.14371862
70cotranslational protein targeting to membrane (GO:0006613)3.14192421
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.11633401
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11633401
73rRNA metabolic process (GO:0016072)3.11480014
74DNA ligation (GO:0006266)3.11196216
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.10417570
76translation (GO:0006412)3.10195796
77pseudouridine synthesis (GO:0001522)3.09609154
78protein neddylation (GO:0045116)3.09552804
79mitochondrial respiratory chain complex assembly (GO:0033108)3.08686290
80cell cycle G1/S phase transition (GO:0044843)3.08636034
81G1/S transition of mitotic cell cycle (GO:0000082)3.08636034
82protein targeting to ER (GO:0045047)3.07934178
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05845737
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05845737
85translational elongation (GO:0006414)3.05783727
86translational initiation (GO:0006413)2.98409522
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96911014
88transcription initiation from RNA polymerase I promoter (GO:0006361)2.96409627
89DNA double-strand break processing (GO:0000729)2.96320833
90cellular component biogenesis (GO:0044085)2.95806906
91protein localization to endoplasmic reticulum (GO:0070972)2.95567901
92tRNA aminoacylation for protein translation (GO:0006418)2.94611434
93DNA damage response, detection of DNA damage (GO:0042769)2.93945112
94ribosome assembly (GO:0042255)2.91771619
95tRNA aminoacylation (GO:0043039)2.91093573
96amino acid activation (GO:0043038)2.91093573
97DNA replication-dependent nucleosome organization (GO:0034723)2.91023042
98DNA replication-dependent nucleosome assembly (GO:0006335)2.91023042
99establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90747114
100fatty acid elongation (GO:0030497)2.90447464
101rRNA modification (GO:0000154)2.90390030
102establishment of viral latency (GO:0019043)2.90242679
103regulation of cellular amino acid metabolic process (GO:0006521)2.87431693
104folic acid-containing compound biosynthetic process (GO:0009396)2.86166737
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85612298
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85253157
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.85253157
108amino acid salvage (GO:0043102)2.84171569
109L-methionine salvage (GO:0071267)2.84171569
110L-methionine biosynthetic process (GO:0071265)2.84171569
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83005996
112ubiquinone metabolic process (GO:0006743)2.82408807
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82278552
114positive regulation of ligase activity (GO:0051351)2.81335381
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81333668
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80735889
117GTP biosynthetic process (GO:0006183)2.79739475
118respiratory chain complex IV assembly (GO:0008535)2.79576988
119ubiquinone biosynthetic process (GO:0006744)2.78713508
120peptidyl-histidine modification (GO:0018202)2.76099357
121aldehyde catabolic process (GO:0046185)2.74932810
122nonmotile primary cilium assembly (GO:0035058)2.73591291
123replication fork processing (GO:0031297)2.68861019
124tRNA metabolic process (GO:0006399)2.63121268
125positive regulation of mitochondrial fission (GO:0090141)2.60511307
126protein-cofactor linkage (GO:0018065)2.60339605
127* serine family amino acid biosynthetic process (GO:0009070)2.60024204
128organelle disassembly (GO:1903008)2.56430927
129tRNA processing (GO:0008033)2.56001078
130branched-chain amino acid catabolic process (GO:0009083)2.55444518
131behavioral response to nicotine (GO:0035095)2.51766621
132cholesterol biosynthetic process (GO:0006695)2.50081147
133respiratory electron transport chain (GO:0022904)2.49376483
134electron transport chain (GO:0022900)2.48726367
135histone exchange (GO:0043486)2.48016800
136mannosylation (GO:0097502)2.46000705
137ribonucleoprotein complex disassembly (GO:0032988)2.45508263
138protein targeting to mitochondrion (GO:0006626)2.44821637
139mitochondrial RNA metabolic process (GO:0000959)2.43134601
140cytochrome complex assembly (GO:0017004)2.42886692
141* serine family amino acid metabolic process (GO:0009069)2.40361762
142serine family amino acid catabolic process (GO:0009071)2.38662657
143intraciliary transport (GO:0042073)2.37287975
144establishment of protein localization to mitochondrion (GO:0072655)2.37040854
145isoprenoid biosynthetic process (GO:0008299)2.36726029
146base-excision repair, AP site formation (GO:0006285)2.36002859
147pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.35739695
148glycine metabolic process (GO:0006544)2.35252497
149pteridine-containing compound biosynthetic process (GO:0042559)2.34200816
150sterol biosynthetic process (GO:0016126)2.33554948
151protein localization to mitochondrion (GO:0070585)2.33176237
152histone mRNA metabolic process (GO:0008334)2.31890517
153DNA catabolic process, exonucleolytic (GO:0000738)2.31142827
154glyoxylate metabolic process (GO:0046487)2.30940091
155protein K6-linked ubiquitination (GO:0085020)2.30247087
156rRNA methylation (GO:0031167)2.30079453
157pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.29540974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.12501579
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.39704682
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24486814
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65571451
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.56803065
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56418372
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51990815
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31974073
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20524843
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.20106153
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.19849400
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10590877
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08125574
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04735670
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00246086
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93479624
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87784563
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59775650
19ZNF274_21170338_ChIP-Seq_K562_Hela2.59333469
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56827704
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56451875
22VDR_23849224_ChIP-Seq_CD4+_Human2.48107807
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41657764
24XRN2_22483619_ChIP-Seq_HELA_Human2.39616072
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32500952
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31341979
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28233522
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.28106651
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26113154
30DCP1A_22483619_ChIP-Seq_HELA_Human2.25275720
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.19084781
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17938571
33ELK1_19687146_ChIP-ChIP_HELA_Human2.16418366
34FOXP3_21729870_ChIP-Seq_TREG_Human2.15452051
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12843428
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07266361
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04560818
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.99591939
39IGF1R_20145208_ChIP-Seq_DFB_Human1.99526458
40GABP_19822575_ChIP-Seq_HepG2_Human1.92114348
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.90155617
42TTF2_22483619_ChIP-Seq_HELA_Human1.86757327
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83901408
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79653728
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79164640
46EWS_26573619_Chip-Seq_HEK293_Human1.76358606
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74282772
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73814084
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72779320
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66398963
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66009447
52AR_21909140_ChIP-Seq_LNCAP_Human1.62549189
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62482763
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62143816
55VDR_22108803_ChIP-Seq_LS180_Human1.61766391
56FUS_26573619_Chip-Seq_HEK293_Human1.55386642
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51809792
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.48368080
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44175398
60* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43597442
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38774544
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38577457
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38569951
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36606509
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36351607
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32271832
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27570927
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25177073
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.22377433
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21527737
71KDM5A_27292631_Chip-Seq_BREAST_Human1.21368786
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18738839
73TAF15_26573619_Chip-Seq_HEK293_Human1.18670626
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18111354
75P300_19829295_ChIP-Seq_ESCs_Human1.17902282
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17225969
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16863461
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15732032
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14370632
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13876125
81GBX2_23144817_ChIP-Seq_PC3_Human1.12462969
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.11127346
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10562561
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09790798
85CIITA_25753668_ChIP-Seq_RAJI_Human1.09065239
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08613245
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07604771
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07084182
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05248977
90MYC_18940864_ChIP-ChIP_HL60_Human1.05009925
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04728099
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03907175
93* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03433157
94* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02662644
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02007808
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01402009
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01225401
98IRF1_19129219_ChIP-ChIP_H3396_Human1.01201329
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00922114
100TFEB_21752829_ChIP-Seq_HELA_Human1.00295051
101TP53_22573176_ChIP-Seq_HFKS_Human0.99641675
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99403532
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.96470557
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96072162
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92766991
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.92431393
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92367153
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91015363
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90805749
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89530539
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88555513
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87012566
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85219824
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83911229
115* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83429795
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82052963
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81958855
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80335002
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80335002
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80335002
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80319344
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80254896
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80203767
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79930261
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78569360
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.78558325
127RNF2_27304074_Chip-Seq_NSC_Mouse0.78149236
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78064843
129CBP_20019798_ChIP-Seq_JUKART_Human0.78064843
130SPI1_23547873_ChIP-Seq_NB4_Human0.76812608
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75185452
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74781087
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.74068271
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72596401
135* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71938780
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71647126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.89137401
2MP0003693_abnormal_embryo_hatching3.60755100
3MP0004957_abnormal_blastocyst_morpholog3.54336348
4MP0008057_abnormal_DNA_replication3.48239967
5MP0003136_yellow_coat_color3.32896168
6MP0008058_abnormal_DNA_repair3.27004498
7MP0003077_abnormal_cell_cycle3.16576454
8MP0003111_abnormal_nucleus_morphology3.04620615
9MP0008932_abnormal_embryonic_tissue2.78037141
10MP0008007_abnormal_cellular_replicative2.76559253
11MP0000566_synostosis2.06484072
12MP0003186_abnormal_redox_activity2.05329867
13MP0003786_premature_aging2.04410031
14MP0003011_delayed_dark_adaptation2.02909012
15MP0003950_abnormal_plasma_membrane2.02369495
16MP0005171_absent_coat_pigmentation2.00241303
17MP0003122_maternal_imprinting1.95381844
18MP0006292_abnormal_olfactory_placode1.95272558
19MP0003806_abnormal_nucleotide_metabolis1.88360502
20MP0006072_abnormal_retinal_apoptosis1.81506720
21MP0002938_white_spotting1.79084041
22MP0002102_abnormal_ear_morphology1.76856490
23MP0010030_abnormal_orbit_morphology1.76390877
24MP0002396_abnormal_hematopoietic_system1.75737821
25MP0004133_heterotaxia1.71748561
26MP0008877_abnormal_DNA_methylation1.71501425
27MP0002132_abnormal_respiratory_system1.65394548
28MP0005551_abnormal_eye_electrophysiolog1.59958915
29MP0001984_abnormal_olfaction1.58624464
30MP0003195_calcinosis1.57445753
31MP0004147_increased_porphyrin_level1.52547194
32MP0000350_abnormal_cell_proliferation1.52244301
33MP0003123_paternal_imprinting1.48647566
34MP0002736_abnormal_nociception_after1.48579847
35MP0002638_abnormal_pupillary_reflex1.45207315
36MP0002234_abnormal_pharynx_morphology1.45006997
37MP0006035_abnormal_mitochondrial_morpho1.44462345
38MP0003787_abnormal_imprinting1.43771809
39MP0008789_abnormal_olfactory_epithelium1.42125457
40MP0005084_abnormal_gallbladder_morpholo1.34885940
41MP0001730_embryonic_growth_arrest1.34811243
42MP0003718_maternal_effect1.34478960
43MP0000631_abnormal_neuroendocrine_gland1.34064017
44MP0009333_abnormal_splenocyte_physiolog1.33102705
45MP0006276_abnormal_autonomic_nervous1.31093738
46MP0002233_abnormal_nose_morphology1.29717494
47MP0001293_anophthalmia1.29363674
48MP0001986_abnormal_taste_sensitivity1.28618288
49MP0004134_abnormal_chest_morphology1.25532993
50MP0001853_heart_inflammation1.23341774
51MP0003763_abnormal_thymus_physiology1.22323792
52MP0000647_abnormal_sebaceous_gland1.22053608
53MP0002653_abnormal_ependyma_morphology1.21365128
54MP0000778_abnormal_nervous_system1.16453897
55MP0001485_abnormal_pinna_reflex1.16333267
56MP0003880_abnormal_central_pattern1.16131546
57MP0003941_abnormal_skin_development1.14653980
58MP0008875_abnormal_xenobiotic_pharmacok1.13151088
59MP0005075_abnormal_melanosome_morpholog1.12947641
60MP0002210_abnormal_sex_determination1.11194612
61MP0000490_abnormal_crypts_of1.10962077
62MP0009379_abnormal_foot_pigmentation1.10420306
63MP0000049_abnormal_middle_ear1.09138387
64MP0003119_abnormal_digestive_system1.08570572
65MP0001529_abnormal_vocalization1.05756531
66MP0005332_abnormal_amino_acid1.05716266
67MP0003755_abnormal_palate_morphology1.05164524
68MP0002751_abnormal_autonomic_nervous1.03756451
69MP0003937_abnormal_limbs/digits/tail_de1.03483295
70MP0000920_abnormal_myelination1.03102251
71MP0002697_abnormal_eye_size1.02066061
72MP0001968_abnormal_touch/_nociception1.00935949
73MP0000358_abnormal_cell_content/0.99799034
74MP0000313_abnormal_cell_death0.99762317
75MP0002090_abnormal_vision0.99511585
76MP0001542_abnormal_bone_strength0.99361872
77MP0001145_abnormal_male_reproductive0.97303134
78MP0002080_prenatal_lethality0.96790548
79MP0004381_abnormal_hair_follicle0.96354135
80MP0005645_abnormal_hypothalamus_physiol0.96138468
81MP0006036_abnormal_mitochondrial_physio0.96007127
82MP0009046_muscle_twitch0.95864048
83MP0005195_abnormal_posterior_eye0.95288818
84MP0002085_abnormal_embryonic_tissue0.94996996
85MP0008438_abnormal_cutaneous_collagen0.92159734
86MP0002019_abnormal_tumor_incidence0.92089053
87MP0001697_abnormal_embryo_size0.91938714
88MP0002111_abnormal_tail_morphology0.91497281
89MP0001764_abnormal_homeostasis0.91451198
90MP0000858_altered_metastatic_potential0.90210465
91MP0001672_abnormal_embryogenesis/_devel0.89689971
92MP0005380_embryogenesis_phenotype0.89689971
93MP0003121_genomic_imprinting0.89456383
94MP0002837_dystrophic_cardiac_calcinosis0.88757148
95MP0002557_abnormal_social/conspecific_i0.87718301
96MP0001188_hyperpigmentation0.86753277
97MP0002282_abnormal_trachea_morphology0.83554295
98MP0003861_abnormal_nervous_system0.83454948
99MP0002752_abnormal_somatic_nervous0.82937805
100MP0002095_abnormal_skin_pigmentation0.82614896
101MP0005253_abnormal_eye_physiology0.82424098
102MP0001324_abnormal_eye_pigmentation0.82082757
103MP0003315_abnormal_perineum_morphology0.81238040
104MP0001286_abnormal_eye_development0.81073685
105MP0001905_abnormal_dopamine_level0.80953799
106MP0002160_abnormal_reproductive_system0.80425850
107MP0002184_abnormal_innervation0.79708334
108MP0000653_abnormal_sex_gland0.78595978
109MP0010352_gastrointestinal_tract_polyps0.78032150
110MP0001929_abnormal_gametogenesis0.77891761
111MP0005646_abnormal_pituitary_gland0.77560106
112MP0000372_irregular_coat_pigmentation0.76884499
113MP0003698_abnormal_male_reproductive0.76255410
114MP0008872_abnormal_physiological_respon0.76027227
115MP0005394_taste/olfaction_phenotype0.74942464
116MP0005499_abnormal_olfactory_system0.74942464
117MP0004197_abnormal_fetal_growth/weight/0.74786715
118MP0002084_abnormal_developmental_patter0.74101151
119MP0003984_embryonic_growth_retardation0.73998532
120MP0001299_abnormal_eye_distance/0.73823538
121MP0005187_abnormal_penis_morphology0.73708666
122MP0002734_abnormal_mechanical_nocicepti0.73299980
123MP0000516_abnormal_urinary_system0.72406472
124MP0005367_renal/urinary_system_phenotyp0.72406472
125MP0003938_abnormal_ear_development0.71612472
126MP0001119_abnormal_female_reproductive0.69273868
127MP0000689_abnormal_spleen_morphology0.68981192
128MP0004142_abnormal_muscle_tone0.68792629
129MP0005501_abnormal_skin_physiology0.67818068
130MP0005391_vision/eye_phenotype0.67527840
131MP0002088_abnormal_embryonic_growth/wei0.67356175
132MP0009250_abnormal_appendicular_skeleto0.67267961
133MP0002398_abnormal_bone_marrow0.67229481
134MP0003878_abnormal_ear_physiology0.66892198
135MP0005377_hearing/vestibular/ear_phenot0.66892198
136MP0002722_abnormal_immune_system0.65954274
137MP0009697_abnormal_copulation0.65218206
138MP0002405_respiratory_system_inflammati0.64891128
139MP0000703_abnormal_thymus_morphology0.63357248
140MP0005389_reproductive_system_phenotype0.62810071
141MP0000428_abnormal_craniofacial_morphol0.62609173
142MP0003936_abnormal_reproductive_system0.62109429
143MP0008260_abnormal_autophagy0.61569598
144MP0003890_abnormal_embryonic-extraembry0.61077299
145MP0005408_hypopigmentation0.59792321
146MP0003567_abnormal_fetal_cardiomyocyte0.59353110
147MP0002429_abnormal_blood_cell0.59077579
148MP0000015_abnormal_ear_pigmentation0.58663292

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)3.69320745
2Birth length less than 3rd percentile (HP:0003561)3.56932799
3Acute encephalopathy (HP:0006846)3.36355371
4Increased serum pyruvate (HP:0003542)3.16864669
5Abnormality of glycolysis (HP:0004366)3.16864669
6Hyperglycinemia (HP:0002154)3.14797248
7Breast hypoplasia (HP:0003187)3.06622524
8Lipid accumulation in hepatocytes (HP:0006561)2.97786595
9Reticulocytopenia (HP:0001896)2.94914013
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94466881
11Chromsome breakage (HP:0040012)2.91009038
12Colon cancer (HP:0003003)2.87416231
13Progressive macrocephaly (HP:0004481)2.84150981
14Irregular epiphyses (HP:0010582)2.82317071
15Abnormality of the labia minora (HP:0012880)2.80183949
16Abnormality of cells of the erythroid lineage (HP:0012130)2.78672247
17Duplicated collecting system (HP:0000081)2.78561329
18Medial flaring of the eyebrow (HP:0010747)2.76896490
19Type I transferrin isoform profile (HP:0003642)2.75064982
20Abnormal number of erythroid precursors (HP:0012131)2.60808866
21Abnormality of alanine metabolism (HP:0010916)2.58057222
22Hyperalaninemia (HP:0003348)2.58057222
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58057222
24Abnormality of the renal collecting system (HP:0004742)2.54240029
25Hypoplastic pelvis (HP:0008839)2.52465664
26Molar tooth sign on MRI (HP:0002419)2.51988748
27Abnormality of midbrain morphology (HP:0002418)2.51988748
283-Methylglutaconic aciduria (HP:0003535)2.49992971
29Septo-optic dysplasia (HP:0100842)2.48660391
30Hepatic necrosis (HP:0002605)2.47950335
31Carpal bone hypoplasia (HP:0001498)2.47281925
32Abnormality of glycine metabolism (HP:0010895)2.47027600
33Abnormality of serine family amino acid metabolism (HP:0010894)2.47027600
34Cerebral edema (HP:0002181)2.46642438
35Abnormality of serum amino acid levels (HP:0003112)2.46016906
36Selective tooth agenesis (HP:0001592)2.45732724
37Congenital primary aphakia (HP:0007707)2.45647297
38Adrenal hypoplasia (HP:0000835)2.45158720
39Gait imbalance (HP:0002141)2.42398249
40Premature graying of hair (HP:0002216)2.40045148
41Macrocytic anemia (HP:0001972)2.39338175
42Meckel diverticulum (HP:0002245)2.38188014
43Hyperglycinuria (HP:0003108)2.32576672
44Abnormality of the umbilical cord (HP:0010881)2.32542661
45Calcaneovalgus deformity (HP:0001848)2.32444144
46Poor head control (HP:0002421)2.30433577
47CNS hypomyelination (HP:0003429)2.30321278
48Abnormality of the ileum (HP:0001549)2.30180634
49Nephrogenic diabetes insipidus (HP:0009806)2.29611846
50Sclerocornea (HP:0000647)2.29526411
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25817431
52Nephronophthisis (HP:0000090)2.25378328
53Postnatal microcephaly (HP:0005484)2.23850121
54Increased serum lactate (HP:0002151)2.23616767
55Abnormality of the preputium (HP:0100587)2.23088882
56Patellar aplasia (HP:0006443)2.22912381
57Absent radius (HP:0003974)2.21390702
58Rough bone trabeculation (HP:0100670)2.20479057
59Degeneration of anterior horn cells (HP:0002398)2.19908009
60Abnormality of the anterior horn cell (HP:0006802)2.19908009
61Lactic acidosis (HP:0003128)2.19880147
62Renal Fanconi syndrome (HP:0001994)2.19094880
63Aplastic anemia (HP:0001915)2.19012804
64Acute necrotizing encephalopathy (HP:0006965)2.18927565
65Methylmalonic acidemia (HP:0002912)2.18371495
66Absent forearm bone (HP:0003953)2.14900609
67Aplasia involving forearm bones (HP:0009822)2.14900609
68Type 2 muscle fiber atrophy (HP:0003554)2.11992536
69Absent thumb (HP:0009777)2.11405124
70Sloping forehead (HP:0000340)2.11129563
71Abnormality of chromosome stability (HP:0003220)2.09154917
72Increased CSF lactate (HP:0002490)2.08791520
73Asplenia (HP:0001746)2.08745306
74Increased hepatocellular lipid droplets (HP:0006565)2.07950617
75Parakeratosis (HP:0001036)2.07948346
76Mitochondrial inheritance (HP:0001427)2.07870530
77Microvesicular hepatic steatosis (HP:0001414)2.07858432
78Ectopic kidney (HP:0000086)2.07367777
79Genital tract atresia (HP:0001827)2.06822981
80Vaginal atresia (HP:0000148)2.06145245
81True hermaphroditism (HP:0010459)2.06094992
82Pendular nystagmus (HP:0012043)2.04845894
83Aplasia/Hypoplasia of the patella (HP:0006498)2.03586102
84Deformed tarsal bones (HP:0008119)2.03179413
85Abnormal protein glycosylation (HP:0012346)2.02492897
86Abnormal glycosylation (HP:0012345)2.02492897
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02492897
88Abnormal protein N-linked glycosylation (HP:0012347)2.02492897
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02003337
90Medulloblastoma (HP:0002885)2.01895345
91Bone marrow hypocellularity (HP:0005528)2.01420228
9211 pairs of ribs (HP:0000878)2.00142032
93Hepatocellular necrosis (HP:0001404)2.00132618
94Methylmalonic aciduria (HP:0012120)1.97232242
95Supernumerary spleens (HP:0009799)1.96769658
96Oral leukoplakia (HP:0002745)1.96184996
97Short tibia (HP:0005736)1.96018671
98Megaloblastic anemia (HP:0001889)1.95772743
99Absent epiphyses (HP:0010577)1.95290309
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95290309
101Aplasia/Hypoplasia of the spleen (HP:0010451)1.95187925
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.94422020
103Patchy hypopigmentation of hair (HP:0011365)1.94388159
104Optic disc pallor (HP:0000543)1.93563152
105Anencephaly (HP:0002323)1.93419867
106Abnormal lung lobation (HP:0002101)1.93283222
107Muscle fiber atrophy (HP:0100295)1.92536379
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92471216
109Abnormal mitochondria in muscle tissue (HP:0008316)1.92310682
110Abnormality of the fetal cardiovascular system (HP:0010948)1.92041841
111Abnormal umbilical cord blood vessels (HP:0011403)1.92041841
112Single umbilical artery (HP:0001195)1.92041841
113Hypoplasia of the pons (HP:0012110)1.90861998
114Glossoptosis (HP:0000162)1.90227523
115Optic nerve hypoplasia (HP:0000609)1.90048317
116Poor suck (HP:0002033)1.89828971
117Bile duct proliferation (HP:0001408)1.89390543
118Abnormal biliary tract physiology (HP:0012439)1.89390543
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88710037
120Absent septum pellucidum (HP:0001331)1.87857244
121Type II lissencephaly (HP:0007260)1.87797312
122Triphalangeal thumb (HP:0001199)1.87130007
123Lissencephaly (HP:0001339)1.86035882
124Horseshoe kidney (HP:0000085)1.85452956
125Broad foot (HP:0001769)1.85319460
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.85134519
127Abnormality of the pons (HP:0007361)1.85035820
128Anophthalmia (HP:0000528)1.84546386
129Abnormality of the calcaneus (HP:0008364)1.83138297
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.82995562
131Trismus (HP:0000211)1.82885750
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82865749
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82622301
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81872843
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81872843
136Abnormal respiratory epithelium morphology (HP:0012253)1.81771392
137Abnormal respiratory motile cilium morphology (HP:0005938)1.81771392
138Lethargy (HP:0001254)1.81574060
139Stenosis of the external auditory canal (HP:0000402)1.81471659
140Pancytopenia (HP:0001876)1.79928566
141Dandy-Walker malformation (HP:0001305)1.79655760
142Median cleft lip (HP:0000161)1.79457308
143Morphological abnormality of the inner ear (HP:0011390)1.78822727
144Abnormality of the renal medulla (HP:0100957)1.78461608
145Preaxial hand polydactyly (HP:0001177)1.78176896
146Leukodystrophy (HP:0002415)1.77769819
147Pancreatic cysts (HP:0001737)1.77313301
148Exercise intolerance (HP:0003546)1.76755680
149Pterygium (HP:0001059)1.76530733
150Pallor (HP:0000980)1.75829012
151Abnormality of methionine metabolism (HP:0010901)1.75631236
152Abolished electroretinogram (ERG) (HP:0000550)1.75419890
153Prolonged neonatal jaundice (HP:0006579)1.74999667
154Pancreatic fibrosis (HP:0100732)1.74948400
155Increased intramyocellular lipid droplets (HP:0012240)1.74892691
156Cortical dysplasia (HP:0002539)1.74305034
157Postaxial foot polydactyly (HP:0001830)1.72494175
158Hypoglycemic coma (HP:0001325)1.72302426
159Postaxial hand polydactyly (HP:0001162)1.71581029
160Bifid tongue (HP:0010297)1.68107008
161Respiratory failure (HP:0002878)1.66730432
162Cystic liver disease (HP:0006706)1.66386144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.27083520
2EIF2AK13.46374237
3WEE13.29802166
4STK163.15808533
5VRK22.87334254
6NME22.72686905
7EIF2AK32.60206458
8CDC72.47641120
9VRK12.38740526
10PBK2.36270219
11SRPK12.24868978
12TESK22.19270255
13BRSK22.17182667
14TSSK62.13310325
15NUAK12.12942339
16TRIM282.06445006
17MAP4K22.05507534
18MKNK12.05289041
19MST42.00900798
20WNK31.97160326
21MAP3K41.81698603
22MAP2K71.77061828
23PIM21.69524957
24RPS6KB21.67628007
25FRK1.64369748
26PASK1.62124833
27WNK41.61305753
28TAF11.59820966
29PLK41.59469338
30TLK11.58449747
31CASK1.54517368
32LIMK11.49663979
33CDK71.47417762
34CSNK1G21.46773430
35CSNK1G11.45769355
36BRSK11.45681596
37ZAK1.42514813
38MKNK21.38882574
39GRK11.36820345
40CSNK1A1L1.33804119
41BCR1.31379767
42PLK31.30323600
43TTK1.29205931
44CCNB11.28754118
45PLK11.27698258
46PLK21.27408089
47DYRK21.22431400
48TXK1.22298704
49ATR1.19188489
50AURKA1.13796084
51STK38L1.12991814
52EPHA21.12011535
53AURKB1.10806148
54ACVR1B1.09848642
55CHEK21.08326267
56STK101.05366561
57TESK11.04455943
58ERBB41.01140388
59EIF2AK20.99347032
60RPS6KA50.99105624
61FLT30.96436530
62CLK10.93920419
63PDK20.91994690
64ERBB30.89776527
65CDK80.88988677
66DYRK30.88160621
67CHEK10.85831408
68NEK60.84576822
69PAK10.83894008
70INSRR0.81417295
71MAPK130.81112198
72RPS6KA40.80944469
73PINK10.78091679
74MAPKAPK50.77320027
75BCKDK0.74383327
76PIM10.73625461
77YES10.71769897
78MAP3K80.70561900
79TNIK0.69848153
80NEK20.69608118
81NME10.68182689
82CSNK2A10.67769475
83MAP3K120.67660345
84PRPF4B0.65884611
85STK40.65746631
86STK390.65085675
87PRKCE0.64717361
88TRPM70.63720537
89TEC0.63667673
90TAOK20.63412001
91ILK0.62559648
92PRKCG0.61610748
93MAP4K10.61579419
94PNCK0.61185366
95PAK40.60148986
96CSNK2A20.58746272
97IKBKB0.57923216
98BTK0.57442708
99ROCK20.57027035
100CDK30.54016802
101MARK10.53271633
102ATM0.51970451
103MINK10.51901707
104MAP3K30.51885981
105CSNK1E0.50340584
106CDK20.49965076
107PAK30.49495967
108OXSR10.48930036
109MAPKAPK30.48493191
110IRAK30.47725080
111SCYL20.47272068
112STK30.45335956
113CDK190.45092362
114EEF2K0.43140270
115ADRBK20.42978926
116CSNK1A10.42702837
117CDK10.42409900
118DAPK10.42323541
119LRRK20.41884560
120MET0.41741423
121PHKG10.41202787
122PHKG20.41202787
123NEK10.40935897
124CSNK1G30.40750484
125MAP2K30.39751123
126OBSCN0.39692944
127PRKCI0.36449667
128LYN0.35876367
129MUSK0.35772281
130TGFBR10.35311070
131SIK30.34926927
132MAPKAPK20.34915095
133TIE10.32894194
134MARK30.32422675
135AKT20.32400538
136CAMK2A0.30731122
137BRAF0.30684736
138RPS6KB10.30668550
139JAK30.29960625
140BMPR1B0.27798698
141PDK30.27779159
142PDK40.27779159
143CDK40.27726818

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19856091
2Mismatch repair_Homo sapiens_hsa034303.67681407
3Proteasome_Homo sapiens_hsa030503.64069027
4Ribosome_Homo sapiens_hsa030103.41781614
5RNA polymerase_Homo sapiens_hsa030203.37284988
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03900190
7Nucleotide excision repair_Homo sapiens_hsa034202.81589595
8Homologous recombination_Homo sapiens_hsa034402.78104275
9Base excision repair_Homo sapiens_hsa034102.69496134
10Spliceosome_Homo sapiens_hsa030402.67140658
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59001249
12One carbon pool by folate_Homo sapiens_hsa006702.55728571
13RNA transport_Homo sapiens_hsa030132.25971033
14Non-homologous end-joining_Homo sapiens_hsa034502.24465331
15Pyrimidine metabolism_Homo sapiens_hsa002402.21685577
16Basal transcription factors_Homo sapiens_hsa030222.13582239
17Protein export_Homo sapiens_hsa030602.06301890
18Cell cycle_Homo sapiens_hsa041101.96420399
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93828867
20Vitamin B6 metabolism_Homo sapiens_hsa007501.91689324
21Fanconi anemia pathway_Homo sapiens_hsa034601.85948319
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82305511
23Propanoate metabolism_Homo sapiens_hsa006401.80764289
24Fatty acid elongation_Homo sapiens_hsa000621.78017155
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77002435
26Steroid biosynthesis_Homo sapiens_hsa001001.75221483
27Selenocompound metabolism_Homo sapiens_hsa004501.71892177
28RNA degradation_Homo sapiens_hsa030181.61178374
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51732890
30Oxidative phosphorylation_Homo sapiens_hsa001901.48651249
31Butanoate metabolism_Homo sapiens_hsa006501.46626127
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42341857
33Parkinsons disease_Homo sapiens_hsa050121.36457269
34Purine metabolism_Homo sapiens_hsa002301.33804401
35Huntingtons disease_Homo sapiens_hsa050161.18560445
36Peroxisome_Homo sapiens_hsa041461.15568761
37p53 signaling pathway_Homo sapiens_hsa041151.03313920
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02728542
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00033571
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98277588
41mRNA surveillance pathway_Homo sapiens_hsa030150.97941478
42Cardiac muscle contraction_Homo sapiens_hsa042600.97721048
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96174707
44Glutathione metabolism_Homo sapiens_hsa004800.96144336
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95345067
46Epstein-Barr virus infection_Homo sapiens_hsa051690.89125346
47Folate biosynthesis_Homo sapiens_hsa007900.87612621
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86811943
49Systemic lupus erythematosus_Homo sapiens_hsa053220.85442308
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.85196916
51Sulfur relay system_Homo sapiens_hsa041220.83942870
52Nitrogen metabolism_Homo sapiens_hsa009100.83688493
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.82895223
54Tryptophan metabolism_Homo sapiens_hsa003800.80294147
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77136055
56Arachidonic acid metabolism_Homo sapiens_hsa005900.77077234
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75863654
58Fatty acid degradation_Homo sapiens_hsa000710.75258313
59beta-Alanine metabolism_Homo sapiens_hsa004100.72849973
60* Biosynthesis of amino acids_Homo sapiens_hsa012300.72600981
61Allograft rejection_Homo sapiens_hsa053300.69032617
62Fat digestion and absorption_Homo sapiens_hsa049750.69017149
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68652387
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67427571
65Ether lipid metabolism_Homo sapiens_hsa005650.66620452
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.66448822
67Sphingolipid metabolism_Homo sapiens_hsa006000.66298631
68Alzheimers disease_Homo sapiens_hsa050100.64298143
69Nicotine addiction_Homo sapiens_hsa050330.63391861
70Primary immunodeficiency_Homo sapiens_hsa053400.63005162
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62668972
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62198242
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61090490
74Retinol metabolism_Homo sapiens_hsa008300.61082590
75Legionellosis_Homo sapiens_hsa051340.59552824
76* Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59500609
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59006949
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.58785937
79Pentose phosphate pathway_Homo sapiens_hsa000300.57509982
80Phototransduction_Homo sapiens_hsa047440.56462632
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56206980
82Herpes simplex infection_Homo sapiens_hsa051680.56110842
83Chemical carcinogenesis_Homo sapiens_hsa052040.56069592
84Arginine and proline metabolism_Homo sapiens_hsa003300.55884721
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53859460
86Autoimmune thyroid disease_Homo sapiens_hsa053200.53436580
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52624535
88* Metabolic pathways_Homo sapiens_hsa011000.52434405
89Graft-versus-host disease_Homo sapiens_hsa053320.51713069
90Viral carcinogenesis_Homo sapiens_hsa052030.51000175
91Antigen processing and presentation_Homo sapiens_hsa046120.50154033
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49973179
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47734403
94Linoleic acid metabolism_Homo sapiens_hsa005910.47668082
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47199265
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44248390
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.44233678
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42531544
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42294420
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41975766
101Arginine biosynthesis_Homo sapiens_hsa002200.41710376
102* Carbon metabolism_Homo sapiens_hsa012000.41590194
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39884998
104Oocyte meiosis_Homo sapiens_hsa041140.39723807
105HTLV-I infection_Homo sapiens_hsa051660.39121563
106Asthma_Homo sapiens_hsa053100.37362311
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35589733
108Type I diabetes mellitus_Homo sapiens_hsa049400.34752306
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34582295
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34457110
111Basal cell carcinoma_Homo sapiens_hsa052170.34437129
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.31158369
113Vitamin digestion and absorption_Homo sapiens_hsa049770.29900585
114Alcoholism_Homo sapiens_hsa050340.29409035
115Fatty acid biosynthesis_Homo sapiens_hsa000610.28535850
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27402684
117Measles_Homo sapiens_hsa051620.27064367
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27059596
119Malaria_Homo sapiens_hsa051440.26845461
120Fructose and mannose metabolism_Homo sapiens_hsa000510.25066112
121Fatty acid metabolism_Homo sapiens_hsa012120.23355258
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.22615817
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22410843
124Hematopoietic cell lineage_Homo sapiens_hsa046400.21665165
125Hippo signaling pathway_Homo sapiens_hsa043900.21165937
126Sulfur metabolism_Homo sapiens_hsa009200.20207944
127Shigellosis_Homo sapiens_hsa051310.20106831
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19500980
129Pyruvate metabolism_Homo sapiens_hsa006200.18313603
130Hedgehog signaling pathway_Homo sapiens_hsa043400.17561143
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14170072
132Rheumatoid arthritis_Homo sapiens_hsa053230.13471313
133Apoptosis_Homo sapiens_hsa042100.13161371

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