PSPC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial DNA replication (GO:0006264)6.59679491
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.28993026
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.09625434
4ribosomal small subunit biogenesis (GO:0042274)5.07357065
5viral transcription (GO:0019083)5.07040814
6translational termination (GO:0006415)4.88716066
7kinetochore assembly (GO:0051382)4.82216823
8ATP synthesis coupled proton transport (GO:0015986)4.71882134
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71882134
10DNA-dependent DNA replication (GO:0006261)4.52710739
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41295064
12cotranslational protein targeting to membrane (GO:0006613)4.35281209
13protein targeting to ER (GO:0045047)4.31597556
14chaperone-mediated protein transport (GO:0072321)4.28260088
15maturation of SSU-rRNA (GO:0030490)4.22452325
16cell wall macromolecule catabolic process (GO:0016998)4.21047142
17mitochondrial DNA metabolic process (GO:0032042)4.13635444
18protein localization to endoplasmic reticulum (GO:0070972)4.06716242
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06065730
20translational elongation (GO:0006414)4.03188162
21ribosomal large subunit biogenesis (GO:0042273)4.00966896
22rRNA modification (GO:0000154)3.99622887
23kinetochore organization (GO:0051383)3.96855879
24CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.94609661
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89653277
26protein complex biogenesis (GO:0070271)3.71218944
27cell wall macromolecule metabolic process (GO:0044036)3.67650753
28cellular protein complex disassembly (GO:0043624)3.67057578
29GTP biosynthetic process (GO:0006183)3.66991447
30response to pheromone (GO:0019236)3.58984363
31ribosomal small subunit assembly (GO:0000028)3.57931259
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54991399
33chromatin remodeling at centromere (GO:0031055)3.53414987
34viral life cycle (GO:0019058)3.52313750
35mitochondrial respiratory chain complex assembly (GO:0033108)3.52114747
36respiratory electron transport chain (GO:0022904)3.48417065
37electron transport chain (GO:0022900)3.46063525
38sperm motility (GO:0030317)3.41170158
39CENP-A containing nucleosome assembly (GO:0034080)3.36674277
40T cell apoptotic process (GO:0070231)3.35349806
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34727800
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.34727800
43NADH dehydrogenase complex assembly (GO:0010257)3.34727800
44translational initiation (GO:0006413)3.34670250
45single strand break repair (GO:0000012)3.31654412
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.31280893
47termination of RNA polymerase III transcription (GO:0006386)3.31280893
48histone exchange (GO:0043486)3.27508251
49protein neddylation (GO:0045116)3.26648729
50resolution of meiotic recombination intermediates (GO:0000712)3.22216396
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16043410
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16043410
53protein complex disassembly (GO:0043241)3.15101746
54translation (GO:0006412)3.14073773
55positive regulation of catecholamine secretion (GO:0033605)3.08816261
56T cell lineage commitment (GO:0002360)3.05572721
57lymphocyte apoptotic process (GO:0070227)3.04489618
58rRNA methylation (GO:0031167)3.04436042
59UTP biosynthetic process (GO:0006228)3.03372045
60water-soluble vitamin biosynthetic process (GO:0042364)3.02887971
61terpenoid biosynthetic process (GO:0016114)3.01514926
62inositol phosphate dephosphorylation (GO:0046855)2.98583123
63phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98583123
64positive regulation of granulocyte differentiation (GO:0030854)2.97342523
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94813311
66macromolecular complex disassembly (GO:0032984)2.94592503
67acrosome reaction (GO:0007340)2.93436229
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89256011
69inositol phosphate catabolic process (GO:0071545)2.89165384
70peptidyl-histidine modification (GO:0018202)2.86765973
71synapsis (GO:0007129)2.85437887
72regulation of mitochondrial translation (GO:0070129)2.83740138
73centriole replication (GO:0007099)2.81639552
74CTP metabolic process (GO:0046036)2.80165814
75CTP biosynthetic process (GO:0006241)2.80165814
76spermatid development (GO:0007286)2.78561313
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77625088
78regulation of chronic inflammatory response (GO:0002676)2.76251522
79nuclear-transcribed mRNA catabolic process (GO:0000956)2.75665886
80DNA damage response, detection of DNA damage (GO:0042769)2.75641765
81negative regulation of alpha-beta T cell differentiation (GO:0046639)2.74507187
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72812430
83ATP biosynthetic process (GO:0006754)2.72020215
84protein polyglutamylation (GO:0018095)2.70180082
85regulation of isotype switching to IgG isotypes (GO:0048302)2.69789717
86cellular component biogenesis (GO:0044085)2.69623178
87male meiosis I (GO:0007141)2.69541742
88UTP metabolic process (GO:0046051)2.68347549
89protein targeting to membrane (GO:0006612)2.66825886
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64447113
91negative regulation of T-helper cell differentiation (GO:0045623)2.62959177
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62959177
93protein-cofactor linkage (GO:0018065)2.62075328
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.61420111
95DNA deamination (GO:0045006)2.61347857
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61185314
97rRNA processing (GO:0006364)2.59325788
98positive regulation of prostaglandin secretion (GO:0032308)2.58861810
99rRNA metabolic process (GO:0016072)2.57931134
100regulation of podosome assembly (GO:0071801)2.57733572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86782590
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.51207937
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49761435
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.80657174
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.23776805
6IGF1R_20145208_ChIP-Seq_DFB_Human2.79610947
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76574185
8ZNF274_21170338_ChIP-Seq_K562_Hela2.76349408
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70177305
10FUS_26573619_Chip-Seq_HEK293_Human2.64323911
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58526228
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39048742
13EZH2_22144423_ChIP-Seq_EOC_Human2.35503874
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.22158513
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.20392935
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18325426
17VDR_22108803_ChIP-Seq_LS180_Human2.12085630
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.06184660
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01434043
20ELK1_19687146_ChIP-ChIP_HELA_Human1.98649518
21VDR_23849224_ChIP-Seq_CD4+_Human1.82791942
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81631763
23EWS_26573619_Chip-Seq_HEK293_Human1.80256669
24MYC_18940864_ChIP-ChIP_HL60_Human1.74722765
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.71169035
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67275226
27IRF1_19129219_ChIP-ChIP_H3396_Human1.65290217
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50734676
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49231417
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.49092970
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48728788
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47452651
33FOXP3_21729870_ChIP-Seq_TREG_Human1.46062806
34P300_19829295_ChIP-Seq_ESCs_Human1.45700030
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44920137
36TAF15_26573619_Chip-Seq_HEK293_Human1.44793015
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44536182
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39651793
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37224081
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35856113
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35487079
42ER_23166858_ChIP-Seq_MCF-7_Human1.35449580
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34855217
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34610676
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34109222
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33524759
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.23978322
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.23845915
49TP53_22573176_ChIP-Seq_HFKS_Human1.19750977
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17083288
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.12969842
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12497006
53TTF2_22483619_ChIP-Seq_HELA_Human1.11843981
54NANOG_20526341_ChIP-Seq_ESCs_Human1.11802119
55CBP_20019798_ChIP-Seq_JUKART_Human1.11046855
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11046855
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08857527
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08446352
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08355130
60ERA_21632823_ChIP-Seq_H3396_Human1.07914252
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06832163
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.06764709
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06764709
64DCP1A_22483619_ChIP-Seq_HELA_Human1.06286484
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.05693168
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.05260983
67BCAT_22108803_ChIP-Seq_LS180_Human1.02954002
68NANOG_19829295_ChIP-Seq_ESCs_Human1.02508786
69SOX2_19829295_ChIP-Seq_ESCs_Human1.02508786
70TAF2_19829295_ChIP-Seq_ESCs_Human1.02470984
71NCOR_22424771_ChIP-Seq_293T_Human1.02224526
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01838322
73AR_20517297_ChIP-Seq_VCAP_Human1.01787969
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01690578
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01376416
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01376416
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99294196
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98979023
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97952824
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.96925672
81MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96143830
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96080519
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95656547
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95411366
85GBX2_23144817_ChIP-Seq_PC3_Human0.95172215
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94593138
87XRN2_22483619_ChIP-Seq_HELA_Human0.94200491
88ERG_20517297_ChIP-Seq_VCAP_Human0.93178491
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92171860
90GABP_19822575_ChIP-Seq_HepG2_Human0.92071930
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91860854
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90162191
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89317518
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89118774
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87883730
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86746866
97AR_25329375_ChIP-Seq_VCAP_Human0.85953185
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.84896571
99RUNX2_22187159_ChIP-Seq_PCA_Human0.84445813
100TCF4_22108803_ChIP-Seq_LS180_Human0.83352712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.51738601
2MP0003880_abnormal_central_pattern3.26042146
3MP0003283_abnormal_digestive_organ3.15837205
4MP0006292_abnormal_olfactory_placode2.99428591
5MP0005646_abnormal_pituitary_gland2.86241680
6MP0002234_abnormal_pharynx_morphology2.79559136
7MP0002653_abnormal_ependyma_morphology2.76492384
8MP0005410_abnormal_fertilization2.53973052
9MP0002837_dystrophic_cardiac_calcinosis2.42351829
10MP0009379_abnormal_foot_pigmentation2.37221546
11MP0000372_irregular_coat_pigmentation2.16767946
12MP0002160_abnormal_reproductive_system2.13529071
13MP0000631_abnormal_neuroendocrine_gland2.13029321
14MP0001984_abnormal_olfaction2.08159618
15MP0006035_abnormal_mitochondrial_morpho2.00835833
16MP0002102_abnormal_ear_morphology2.00704779
17MP0001529_abnormal_vocalization2.00651290
18MP0005645_abnormal_hypothalamus_physiol1.99914857
19MP0006276_abnormal_autonomic_nervous1.99672681
20MP0006072_abnormal_retinal_apoptosis1.95664418
21MP0002638_abnormal_pupillary_reflex1.93618435
22MP0001293_anophthalmia1.91053207
23MP0008875_abnormal_xenobiotic_pharmacok1.85953161
24MP0008872_abnormal_physiological_respon1.78771343
25MP0003315_abnormal_perineum_morphology1.60978220
26MP0006036_abnormal_mitochondrial_physio1.60322187
27MP0002132_abnormal_respiratory_system1.57137753
28MP0008058_abnormal_DNA_repair1.56228507
29MP0005551_abnormal_eye_electrophysiolog1.54358303
30MP0003878_abnormal_ear_physiology1.49798603
31MP0005377_hearing/vestibular/ear_phenot1.49798603
32MP0002938_white_spotting1.49567964
33MP0008877_abnormal_DNA_methylation1.49148882
34MP0003567_abnormal_fetal_cardiomyocyte1.48757126
35MP0008789_abnormal_olfactory_epithelium1.48410830
36MP0002163_abnormal_gland_morphology1.44222986
37MP0003718_maternal_effect1.31784483
38MP0005253_abnormal_eye_physiology1.31589028
39MP0008995_early_reproductive_senescence1.29384305
40MP0009697_abnormal_copulation1.26528820
41MP0001905_abnormal_dopamine_level1.26035800
42MP0005310_abnormal_salivary_gland1.25805779
43MP0000049_abnormal_middle_ear1.25224502
44MP0002277_abnormal_respiratory_mucosa1.24118711
45MP0001968_abnormal_touch/_nociception1.23918910
46MP0001929_abnormal_gametogenesis1.23889261
47MP0003698_abnormal_male_reproductive1.22930226
48MP0005389_reproductive_system_phenotype1.22588208
49MP0001485_abnormal_pinna_reflex1.21233753
50MP0002210_abnormal_sex_determination1.19160868
51MP0003119_abnormal_digestive_system1.16684448
52MP0008057_abnormal_DNA_replication1.16589185
53MP0003186_abnormal_redox_activity1.15119052
54MP0005084_abnormal_gallbladder_morpholo1.12479214
55MP0010386_abnormal_urinary_bladder1.09260492
56MP0005499_abnormal_olfactory_system1.07011193
57MP0005394_taste/olfaction_phenotype1.07011193
58MP0002736_abnormal_nociception_after1.05930271
59MP0004142_abnormal_muscle_tone1.05648375
60MP0002233_abnormal_nose_morphology1.04153509
61MP0009745_abnormal_behavioral_response1.03252199
62MP0001348_abnormal_lacrimal_gland1.03009235
63MP0005391_vision/eye_phenotype0.98522561
64MP0005379_endocrine/exocrine_gland_phen0.97037465
65MP0001145_abnormal_male_reproductive0.95059696
66MP0003786_premature_aging0.94888238
67MP0000653_abnormal_sex_gland0.94776076
68MP0004133_heterotaxia0.94655269
69MP0002735_abnormal_chemical_nociception0.94428929
70MP0003011_delayed_dark_adaptation0.92047719
71MP0005187_abnormal_penis_morphology0.91729890
72MP0008775_abnormal_heart_ventricle0.91405010
73MP0002876_abnormal_thyroid_physiology0.89752385
74MP0004215_abnormal_myocardial_fiber0.87583645
75MP0002734_abnormal_mechanical_nocicepti0.87252492
76MP0001873_stomach_inflammation0.87203300
77MP0002752_abnormal_somatic_nervous0.85424980
78MP0005195_abnormal_posterior_eye0.84484475
79MP0005647_abnormal_sex_gland0.84008931
80MP0001188_hyperpigmentation0.81368551
81MP0005330_cardiomyopathy0.81125117
82MP0004084_abnormal_cardiac_muscle0.80958053
83MP0003221_abnormal_cardiomyocyte_apopto0.80124679
84MP0000749_muscle_degeneration0.77883080
85MP0005075_abnormal_melanosome_morpholog0.77294167
86MP0001727_abnormal_embryo_implantation0.76216919
87MP0001502_abnormal_circadian_rhythm0.76048249
88MP0001440_abnormal_grooming_behavior0.75749439
89MP0002557_abnormal_social/conspecific_i0.75296469
90MP0006138_congestive_heart_failure0.74267235
91MP0003938_abnormal_ear_development0.74019043
92MP0003806_abnormal_nucleotide_metabolis0.73986113
93MP0001661_extended_life_span0.73776736
94MP0004742_abnormal_vestibular_system0.72636698
95MP0003890_abnormal_embryonic-extraembry0.72370896
96MP0001286_abnormal_eye_development0.71870075
97MP0002095_abnormal_skin_pigmentation0.71574006
98MP0009046_muscle_twitch0.70736162
99MP0002751_abnormal_autonomic_nervous0.69812844
100MP0001486_abnormal_startle_reflex0.69141266

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pupillary function (HP:0007686)5.61727705
2Acute necrotizing encephalopathy (HP:0006965)4.70412575
3Abnormal mitochondria in muscle tissue (HP:0008316)4.30763120
4Acute encephalopathy (HP:0006846)4.17066482
5Progressive macrocephaly (HP:0004481)4.01276921
6Pancreatic fibrosis (HP:0100732)3.87696246
7Colon cancer (HP:0003003)3.80059617
8Mitochondrial inheritance (HP:0001427)3.74993309
9Congenital stationary night blindness (HP:0007642)3.72456016
10Abnormality of midbrain morphology (HP:0002418)3.72245440
11Molar tooth sign on MRI (HP:0002419)3.72245440
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37121196
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37121196
14Increased CSF lactate (HP:0002490)3.23462166
15Cerebral edema (HP:0002181)3.21125655
16Pancreatic cysts (HP:0001737)3.18752986
17Median cleft lip (HP:0000161)3.14676934
18Abnormality of cells of the erythroid lineage (HP:0012130)2.95198589
19Macrocytic anemia (HP:0001972)2.91656224
20Hepatocellular necrosis (HP:0001404)2.90102823
213-Methylglutaconic aciduria (HP:0003535)2.73273109
22Reticulocytopenia (HP:0001896)2.69071048
23Optic disc pallor (HP:0000543)2.63875225
24Abolished electroretinogram (ERG) (HP:0000550)2.61532224
25True hermaphroditism (HP:0010459)2.55688970
26Chronic hepatic failure (HP:0100626)2.55516927
27Congenital, generalized hypertrichosis (HP:0004540)2.52490643
28Large for gestational age (HP:0001520)2.52050812
29Abnormal rod and cone electroretinograms (HP:0008323)2.48669407
30Lipid accumulation in hepatocytes (HP:0006561)2.45524193
31Aplastic anemia (HP:0001915)2.43467375
32Pendular nystagmus (HP:0012043)2.40361503
33Increased hepatocellular lipid droplets (HP:0006565)2.36274721
34Chorioretinal atrophy (HP:0000533)2.30155827
35Hepatic necrosis (HP:0002605)2.27741451
36Absent thumb (HP:0009777)2.27073469
37Lactic acidosis (HP:0003128)2.24879257
38Abnormal number of erythroid precursors (HP:0012131)2.24008762
39Aplasia/hypoplasia of the uterus (HP:0008684)2.23744591
40Bony spicule pigmentary retinopathy (HP:0007737)2.23315047
41Hyperglycinemia (HP:0002154)2.19822761
42Leukodystrophy (HP:0002415)2.17717895
43Stenosis of the external auditory canal (HP:0000402)2.13910596
44Attenuation of retinal blood vessels (HP:0007843)2.12891282
45Increased serum lactate (HP:0002151)2.12672124
46Anophthalmia (HP:0000528)2.12433266
47Respiratory failure (HP:0002878)2.10290096
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10059499
49Renal Fanconi syndrome (HP:0001994)2.09973080
50Exercise intolerance (HP:0003546)2.08018308
51Hypoplasia of the ulna (HP:0003022)2.07432015
52Preaxial hand polydactyly (HP:0001177)2.06758938
53Chorioretinal coloboma (HP:0000567)2.06505351
54Nephronophthisis (HP:0000090)2.06050022
55Short tibia (HP:0005736)2.02791842
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01151345
57Anencephaly (HP:0002323)1.98572007
58Pallor (HP:0000980)1.98208569
59Opisthotonus (HP:0002179)1.96995788
60Congenital sensorineural hearing impairment (HP:0008527)1.96206725
61Cystic liver disease (HP:0006706)1.95491902
62Sclerocornea (HP:0000647)1.95025228
63Triphalangeal thumb (HP:0001199)1.89554476
64Abnormal respiratory motile cilium physiology (HP:0012261)1.88111087
65Constricted visual fields (HP:0001133)1.87229664
66Optic nerve hypoplasia (HP:0000609)1.86957375
67Lethargy (HP:0001254)1.86158382
68Occipital encephalocele (HP:0002085)1.85925062
69Aplasia/Hypoplasia of the ulna (HP:0006495)1.85882753
70Cleft eyelid (HP:0000625)1.85482405
71Abnormality of DNA repair (HP:0003254)1.84351634
72Septo-optic dysplasia (HP:0100842)1.83848060
73Medial flaring of the eyebrow (HP:0010747)1.81963430
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81436623
75Abnormality of macular pigmentation (HP:0008002)1.80955684
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.80696441
77Absent/shortened dynein arms (HP:0200106)1.80696441
78Pancytopenia (HP:0001876)1.80512065
79Methylmalonic acidemia (HP:0002912)1.80508501
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.79924365
81Postaxial foot polydactyly (HP:0001830)1.79325565
82Progressive microcephaly (HP:0000253)1.78650018
83Male pseudohermaphroditism (HP:0000037)1.78453868
84Reduced antithrombin III activity (HP:0001976)1.77658413
85Forearm undergrowth (HP:0009821)1.77620123
86Congenital hepatic fibrosis (HP:0002612)1.77591472
87Testicular atrophy (HP:0000029)1.77542000
88Exertional dyspnea (HP:0002875)1.77462211
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.77320885
90Increased intramyocellular lipid droplets (HP:0012240)1.76028634
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74087837
92Abnormality of the renal medulla (HP:0100957)1.73252030
93Abnormal ciliary motility (HP:0012262)1.72922422
94Iris coloboma (HP:0000612)1.70995639
95Abnormal respiratory epithelium morphology (HP:0012253)1.70593524
96Abnormal respiratory motile cilium morphology (HP:0005938)1.70593524
97Meckel diverticulum (HP:0002245)1.69898656
98Methylmalonic aciduria (HP:0012120)1.68656042
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67356223
100Hypoplasia of the radius (HP:0002984)1.66767217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.73755075
2VRK23.48254596
3PINK13.28237281
4PBK2.79119882
5TNIK2.67502350
6PLK42.50551608
7TLK12.43194394
8NME12.41312130
9VRK12.25378628
10CASK2.14668513
11ADRBK22.11126306
12TXK2.03820790
13ZAK2.02627307
14STK38L2.02264097
15PIK3CA1.95451170
16GRK51.91993206
17WNK31.90686091
18STK161.85297783
19WEE11.84328509
20GRK11.80353982
21BCKDK1.76309045
22PNCK1.73720511
23DYRK21.71038500
24MAP4K21.70534747
25DYRK31.50922000
26TAF11.47924939
27DAPK21.40036756
28BMPR1B1.38009826
29MAP2K71.31345064
30OBSCN1.30756151
31FRK1.24907976
32STK41.23290982
33MAPKAPK51.20833814
34MATK1.16403325
35NEK21.13474235
36INSRR1.02597457
37CDC71.01268816
38PLK20.97427019
39CSNK1G20.97271173
40CDK80.93728901
41DAPK10.91600328
42SRPK10.89570597
43CSNK1G30.89119194
44MST40.89113906
45NLK0.88899058
46MAPK130.88849094
47GRK70.87577262
48DAPK30.86683948
49TSSK60.84434436
50MARK30.84289496
51STK30.84155400
52EIF2AK10.83592388
53MAPK150.81248642
54PLK30.81073007
55NEK10.80813247
56NTRK10.79496933
57TAOK30.78882463
58MYLK0.75855778
59NME20.73463517
60PLK10.68740943
61MKNK20.67830128
62CSNK1G10.66786467
63CSNK1A1L0.66324253
64ITK0.64866232
65MAP3K40.64442879
66CDK190.63977344
67TGFBR10.63210425
68MELK0.61956871
69ABL20.61731864
70IKBKB0.60618284
71WNK40.60475072
72CDK30.59338120
73LRRK20.58591615
74PTK2B0.54941549
75ADRBK10.54717429
76TESK20.54699960
77PDK20.54501552
78RPS6KA50.52527669
79MKNK10.52365983
80TNK20.51856362
81KDR0.51101572
82PRKCQ0.51077063
83PRKCG0.50602499
84AURKA0.49153289
85MAPKAPK30.46713326
86PAK30.46545106
87AURKB0.44703629
88TIE10.44702976
89MAP2K20.43335278
90STK240.40809024
91CSNK2A20.37095438
92PIK3CG0.36275983
93BRD40.34626361
94PRKCE0.32890706
95CSNK2A10.32345695
96PRKD30.29717638
97PASK0.29420588
98LATS10.29084048
99ATR0.28490989
100CSNK1A10.27605518

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10962507
2Oxidative phosphorylation_Homo sapiens_hsa001903.99921803
3Parkinsons disease_Homo sapiens_hsa050123.49624768
4Proteasome_Homo sapiens_hsa030503.28186155
5RNA polymerase_Homo sapiens_hsa030203.17699777
6Mismatch repair_Homo sapiens_hsa034302.55449387
7Protein export_Homo sapiens_hsa030602.49648005
8Sulfur relay system_Homo sapiens_hsa041222.36398975
9Huntingtons disease_Homo sapiens_hsa050162.29515295
10DNA replication_Homo sapiens_hsa030302.19529643
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13877341
12Alzheimers disease_Homo sapiens_hsa050102.10179349
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04753929
14Phototransduction_Homo sapiens_hsa047442.02436774
15Cardiac muscle contraction_Homo sapiens_hsa042602.01683389
16Homologous recombination_Homo sapiens_hsa034401.96522859
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78911943
18Nucleotide excision repair_Homo sapiens_hsa034201.78571106
19Asthma_Homo sapiens_hsa053101.66754531
20Fanconi anemia pathway_Homo sapiens_hsa034601.65191579
21Pyrimidine metabolism_Homo sapiens_hsa002401.65170188
22RNA degradation_Homo sapiens_hsa030181.56339318
23Folate biosynthesis_Homo sapiens_hsa007901.46415382
24Spliceosome_Homo sapiens_hsa030401.45835532
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40420104
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38173776
27Purine metabolism_Homo sapiens_hsa002301.33520948
28Autoimmune thyroid disease_Homo sapiens_hsa053201.28930099
29Base excision repair_Homo sapiens_hsa034101.24650198
30Basal transcription factors_Homo sapiens_hsa030221.23924701
31Propanoate metabolism_Homo sapiens_hsa006401.21095865
32Allograft rejection_Homo sapiens_hsa053301.19375726
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14418566
34Olfactory transduction_Homo sapiens_hsa047401.14138856
35RNA transport_Homo sapiens_hsa030131.10403423
36One carbon pool by folate_Homo sapiens_hsa006701.08088532
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06550556
38Nitrogen metabolism_Homo sapiens_hsa009101.04766328
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.02165663
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01049659
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00043939
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.99038663
43Peroxisome_Homo sapiens_hsa041460.98392279
44Butanoate metabolism_Homo sapiens_hsa006500.98068235
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97699456
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88507267
47Hedgehog signaling pathway_Homo sapiens_hsa043400.88238949
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83206810
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.82574790
50Chemical carcinogenesis_Homo sapiens_hsa052040.78388062
51Metabolic pathways_Homo sapiens_hsa011000.78319353
52Systemic lupus erythematosus_Homo sapiens_hsa053220.76109238
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74051297
54Linoleic acid metabolism_Homo sapiens_hsa005910.71765271
55Pyruvate metabolism_Homo sapiens_hsa006200.71186369
56Glutathione metabolism_Homo sapiens_hsa004800.66893951
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65726568
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65697820
59Tryptophan metabolism_Homo sapiens_hsa003800.65203518
60Basal cell carcinoma_Homo sapiens_hsa052170.64712208
61Regulation of autophagy_Homo sapiens_hsa041400.63210153
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62720028
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.62603702
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.61998738
65Retinol metabolism_Homo sapiens_hsa008300.58461437
66Tyrosine metabolism_Homo sapiens_hsa003500.56695285
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56618053
68Steroid biosynthesis_Homo sapiens_hsa001000.55736886
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51276799
70Taste transduction_Homo sapiens_hsa047420.50818592
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49676112
72Nicotine addiction_Homo sapiens_hsa050330.49137540
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44046266
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41737795
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.41512997
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41317852
77Fatty acid elongation_Homo sapiens_hsa000620.39169794
78Arachidonic acid metabolism_Homo sapiens_hsa005900.38600053
79Collecting duct acid secretion_Homo sapiens_hsa049660.37743884
80Sulfur metabolism_Homo sapiens_hsa009200.37683589
81Fatty acid degradation_Homo sapiens_hsa000710.35293527
82Calcium signaling pathway_Homo sapiens_hsa040200.33584959
83beta-Alanine metabolism_Homo sapiens_hsa004100.31103853
84TGF-beta signaling pathway_Homo sapiens_hsa043500.30952362
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30732650
86Fatty acid metabolism_Homo sapiens_hsa012120.30653105
87Antigen processing and presentation_Homo sapiens_hsa046120.29633985
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29439767
89Fat digestion and absorption_Homo sapiens_hsa049750.28694949
90Alcoholism_Homo sapiens_hsa050340.28233850
91Selenocompound metabolism_Homo sapiens_hsa004500.27008335
92Non-homologous end-joining_Homo sapiens_hsa034500.26806512
93GABAergic synapse_Homo sapiens_hsa047270.24242267
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24082972
95mRNA surveillance pathway_Homo sapiens_hsa030150.23393340
96Hematopoietic cell lineage_Homo sapiens_hsa046400.23339317
97p53 signaling pathway_Homo sapiens_hsa041150.20929423
98Caffeine metabolism_Homo sapiens_hsa002320.20868184
99Primary immunodeficiency_Homo sapiens_hsa053400.19598222
100Morphine addiction_Homo sapiens_hsa050320.18321409

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »