PSMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.35042608
2sperm-egg recognition (GO:0035036)5.97328317
3binding of sperm to zona pellucida (GO:0007339)5.91290518
4acrosome reaction (GO:0007340)5.73072172
5cell wall macromolecule metabolic process (GO:0044036)5.69179909
6cell wall macromolecule catabolic process (GO:0016998)5.69179909
7fusion of sperm to egg plasma membrane (GO:0007342)5.21188492
8cell-cell recognition (GO:0009988)5.17440559
9multicellular organism reproduction (GO:0032504)4.97975761
10motile cilium assembly (GO:0044458)4.87213848
11epithelial cilium movement (GO:0003351)4.79078862
12microtubule depolymerization (GO:0007019)4.76372525
13spermatid development (GO:0007286)4.50612903
14axonemal dynein complex assembly (GO:0070286)4.42314230
15regulation of cilium movement (GO:0003352)4.40449229
16acrosome assembly (GO:0001675)4.35708108
17proteasome assembly (GO:0043248)4.35370758
18DNA deamination (GO:0045006)4.28489162
19piRNA metabolic process (GO:0034587)4.27711226
20reproduction (GO:0000003)4.22395555
21protein deneddylation (GO:0000338)4.17181457
22cullin deneddylation (GO:0010388)3.99655615
23Golgi transport vesicle coating (GO:0048200)3.99229859
24COPI coating of Golgi vesicle (GO:0048205)3.99229859
25GDP-mannose metabolic process (GO:0019673)3.97721292
26single strand break repair (GO:0000012)3.88945629
27male meiosis (GO:0007140)3.83787676
28plasma membrane fusion (GO:0045026)3.81635206
29hemoglobin metabolic process (GO:0020027)3.80082470
30oxygen transport (GO:0015671)3.73475791
31cilium movement (GO:0003341)3.64411834
32chromosome condensation (GO:0030261)3.58692953
33single fertilization (GO:0007338)3.58690957
34regulation of superoxide anion generation (GO:0032928)3.53097706
35protoporphyrinogen IX biosynthetic process (GO:0006782)3.49449917
36protein maturation by protein folding (GO:0022417)3.44688803
37cilium or flagellum-dependent cell motility (GO:0001539)3.39921671
38DNA packaging (GO:0006323)3.39378699
39protoporphyrinogen IX metabolic process (GO:0046501)3.38868146
40DNA strand elongation involved in DNA replication (GO:0006271)3.38732621
41* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36501232
42pentose-phosphate shunt (GO:0006098)3.32654542
43GTP biosynthetic process (GO:0006183)3.30675037
44heme biosynthetic process (GO:0006783)3.29623524
45negative regulation of erythrocyte differentiation (GO:0045647)3.29089365
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.29080831
47* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28903913
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27517156
49gas transport (GO:0015669)3.26511066
50histone exchange (GO:0043486)3.25555456
51chromatin remodeling at centromere (GO:0031055)3.24864079
52maturation of 5.8S rRNA (GO:0000460)3.23554124
53DNA strand elongation (GO:0022616)3.23485175
54* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23232789
55porphyrin-containing compound metabolic process (GO:0006778)3.21841121
56protein complex biogenesis (GO:0070271)3.21126269
57telomere maintenance via semi-conservative replication (GO:0032201)3.20558484
58modulation by virus of host process (GO:0019054)3.19908019
59chaperone-mediated protein transport (GO:0072321)3.19810002
60male gamete generation (GO:0048232)3.18939429
61spermatogenesis (GO:0007283)3.18648712
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18291568
63NADH metabolic process (GO:0006734)3.17424746
64CENP-A containing nucleosome assembly (GO:0034080)3.17351230
65pinocytosis (GO:0006907)3.16253742
66* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16128131
67synaptonemal complex organization (GO:0070193)3.14922301
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14195408
69* negative regulation of ligase activity (GO:0051352)3.12019573
70* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12019573
71mitochondrial respiratory chain complex assembly (GO:0033108)3.11329165
72DNA catabolic process, exonucleolytic (GO:0000738)3.10858935
73NADPH regeneration (GO:0006740)3.10520726
74deoxyribonucleotide biosynthetic process (GO:0009263)3.09863493
75* regulation of cellular amino acid metabolic process (GO:0006521)3.08430113
76deoxyribose phosphate biosynthetic process (GO:0046385)3.06803146
772-deoxyribonucleotide biosynthetic process (GO:0009265)3.06803146
78ribosomal small subunit assembly (GO:0000028)3.06477676
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04761937
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.04761937
81NADH dehydrogenase complex assembly (GO:0010257)3.04761937
82DNA methylation involved in gamete generation (GO:0043046)3.04257062
83DNA replication initiation (GO:0006270)3.04080933
84organic cation transport (GO:0015695)3.03324101
85guanosine-containing compound biosynthetic process (GO:1901070)3.03068037
86sperm capacitation (GO:0048240)3.01875724
87cellular hyperosmotic response (GO:0071474)3.01499688
88regulation of mitochondrial translation (GO:0070129)3.00367733
89* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99602246
90synaptonemal complex assembly (GO:0007130)2.99458500
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98680599
92gamete generation (GO:0007276)2.97412507
93metallo-sulfur cluster assembly (GO:0031163)2.97030935
94iron-sulfur cluster assembly (GO:0016226)2.97030935
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95591784
96glucose catabolic process (GO:0006007)2.95590190
97UTP biosynthetic process (GO:0006228)2.94175323
98antigen processing and presentation of endogenous antigen (GO:0019883)2.93878185
993-UTR-mediated mRNA stabilization (GO:0070935)2.93608068
100viral protein processing (GO:0019082)2.93321809
101virion assembly (GO:0019068)2.93305889
102negative regulation of necroptotic process (GO:0060546)2.92279871
103glycerol ether metabolic process (GO:0006662)2.91953940
104* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91602741
105* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91602741
106DNA replication checkpoint (GO:0000076)2.91591590
107tetrapyrrole biosynthetic process (GO:0033014)2.91275221
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91025245
109histone H2A acetylation (GO:0043968)2.90795493
110regulation of spindle checkpoint (GO:0090231)2.90042870
111* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89078112
112* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89078112
113* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89078112
114heme metabolic process (GO:0042168)2.88191787
115very-low-density lipoprotein particle assembly (GO:0034379)2.86920245
116meiotic nuclear division (GO:0007126)2.86824893
117fertilization (GO:0009566)2.86531262
118microtubule polymerization or depolymerization (GO:0031109)2.85359007
119porphyrin-containing compound biosynthetic process (GO:0006779)2.85079735
120regulation of inclusion body assembly (GO:0090083)2.84351472
121modulation by symbiont of host cellular process (GO:0044068)2.83687041
122de novo posttranslational protein folding (GO:0051084)2.81936540
123telomere maintenance via recombination (GO:0000722)2.81650700
124protein-cofactor linkage (GO:0018065)2.81342593
125* positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80518851
126erythrocyte development (GO:0048821)2.80400178
127protein localization to chromosome, centromeric region (GO:0071459)2.77965043
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.77316014
129* signal transduction involved in cell cycle checkpoint (GO:0072395)2.77020514
130positive regulation by symbiont of host defense response (GO:0052509)2.68561159
131modulation by symbiont of host defense response (GO:0052031)2.68561159
132modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68561159
133modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68561159
134positive regulation by organism of defense response of other organism involved in symbiotic interact2.68561159
135modulation by symbiont of host immune response (GO:0052553)2.68561159
136barbed-end actin filament capping (GO:0051016)2.68115495
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67034568
138regulation of response to osmotic stress (GO:0047484)2.64055070
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63727139
140proline biosynthetic process (GO:0006561)2.63201868
141* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62948863
142oxaloacetate metabolic process (GO:0006107)2.62360974
143erythrocyte maturation (GO:0043249)2.58850898
144plasma lipoprotein particle assembly (GO:0034377)2.58584680
145neutrophil activation involved in immune response (GO:0002283)2.58028465
146* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.53508706
147pyrimidine nucleoside salvage (GO:0043097)2.50105018
148pyrimidine-containing compound salvage (GO:0008655)2.50105018
149erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49551112
150L-phenylalanine metabolic process (GO:0006558)2.49551112
151nucleoside diphosphate biosynthetic process (GO:0009133)2.49027457
152cellular response to interleukin-4 (GO:0071353)2.45354076
153glucose 6-phosphate metabolic process (GO:0051156)2.44419667
154negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41897010
155negative regulation of cell killing (GO:0031342)2.41897010
156tricarboxylic acid metabolic process (GO:0072350)2.41540000
157protein-lipid complex assembly (GO:0065005)2.40710439
158hepatocyte apoptotic process (GO:0097284)2.40661217
159positive regulation of gamma-delta T cell activation (GO:0046645)2.40472699
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.39924598
161pentose metabolic process (GO:0019321)2.39667244
162regulation of superoxide metabolic process (GO:0090322)2.38624307
163cellular response to virus (GO:0098586)2.36940650
164positive regulation of lipoprotein lipase activity (GO:0051006)2.35890746
165positive regulation of triglyceride lipase activity (GO:0061365)2.35890746
166negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.35368578
167regulation of necroptotic process (GO:0060544)2.35120779
168positive regulation of cellular amine metabolic process (GO:0033240)2.34674502
169regulation of cholesterol esterification (GO:0010872)2.30974187
170response to peptidoglycan (GO:0032494)2.25322324
171monosaccharide biosynthetic process (GO:0046364)2.25006944
172fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24536008
173positive regulation of granulocyte differentiation (GO:0030854)2.24475397
174negative regulation of fibrinolysis (GO:0051918)2.22693454
175leukocyte aggregation (GO:0070486)2.21011777
176tetrapyrrole metabolic process (GO:0033013)2.20480542
177maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.20357152
178regulation of defense response to virus by virus (GO:0050690)2.20196738
179negative regulation of necrotic cell death (GO:0060547)2.19298405
180NIK/NF-kappaB signaling (GO:0038061)2.17672329
181response to interleukin-4 (GO:0070670)2.17419417
182GMP metabolic process (GO:0046037)2.17101249
183negative regulation of myeloid cell apoptotic process (GO:0033033)2.17057558
184protein retention in ER lumen (GO:0006621)2.16846554
185alpha-linolenic acid metabolic process (GO:0036109)2.16054367
186positive regulation of extracellular matrix organization (GO:1903055)2.15124142
187negative regulation of phagocytosis (GO:0050765)2.14939480
188detection of bacterium (GO:0016045)2.14811645
189low-density lipoprotein particle clearance (GO:0034383)2.14695618
190positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14445542
191regulation of oxidative phosphorylation (GO:0002082)2.14202886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.66995292
2E2F7_22180533_ChIP-Seq_HELA_Human4.63452581
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88539594
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56015808
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.41123501
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.28960251
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.11403280
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77086353
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75780278
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.69098008
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.61537557
12* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60798011
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55790883
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50390856
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44896058
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40571078
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33873975
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32233949
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30112043
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27023319
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24483167
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.23946342
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.22459265
24VDR_23849224_ChIP-Seq_CD4+_Human2.19960655
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15135714
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14557308
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.11117737
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09523567
29MYC_22102868_ChIP-Seq_BL_Human2.05807615
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02435788
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01717106
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01122262
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.98696377
34DCP1A_22483619_ChIP-Seq_HELA_Human1.98244243
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96950325
36VDR_21846776_ChIP-Seq_THP-1_Human1.96137880
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94330849
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93702008
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92981818
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91579717
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90949318
42* GABP_19822575_ChIP-Seq_HepG2_Human1.88114853
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.83922226
44LXR_22292898_ChIP-Seq_THP-1_Human1.77383142
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.74760452
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66538764
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63354463
48ZNF263_19887448_ChIP-Seq_K562_Human1.63053889
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62399410
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59651968
51* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58639386
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.58261569
53XRN2_22483619_ChIP-Seq_HELA_Human1.56146303
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55956872
55EZH2_22144423_ChIP-Seq_EOC_Human1.51788200
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51685918
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49907482
58MAF_26560356_Chip-Seq_TH1_Human1.47762799
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47257065
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47114948
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46740515
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.45949257
63* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44100179
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42896488
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41677220
66UTX_26944678_Chip-Seq_JUKART_Human1.40839211
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39336620
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38784412
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38784347
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38453033
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37455767
72TTF2_22483619_ChIP-Seq_HELA_Human1.36623116
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.36529299
74RACK7_27058665_Chip-Seq_MCF-7_Human1.36422774
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35333348
76SPI1_23547873_ChIP-Seq_NB4_Human1.34707983
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34377950
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.33190001
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32857287
80MAF_26560356_Chip-Seq_TH2_Human1.32484700
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.31233597
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30180227
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30058528
84TCF7_22412390_ChIP-Seq_EML_Mouse1.28759292
85IRF1_19129219_ChIP-ChIP_H3396_Human1.28580938
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26802877
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25792339
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25008969
89* GATA1_19941827_ChIP-Seq_MEL_Mouse1.24919463
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22797399
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22271031
92BCL6_27268052_Chip-Seq_Bcells_Human1.21950120
93VDR_24763502_ChIP-Seq_THP-1_Human1.21679378
94P68_20966046_ChIP-Seq_HELA_Human1.21380599
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21240995
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20537737
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19268766
98BCOR_27268052_Chip-Seq_Bcells_Human1.18744150
99MYC_18940864_ChIP-ChIP_HL60_Human1.18216842
100ELK1_19687146_ChIP-ChIP_HELA_Human1.18012933
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17806726
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17017704
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16395552
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15850051
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15526859
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.15342285
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12994998
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12297646
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12178413
110KDM2B_26808549_Chip-Seq_DND41_Human1.12067382
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11487272
112TFEB_21752829_ChIP-Seq_HELA_Human1.10774805
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09929232
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09821708
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09696158
116E2F1_21310950_ChIP-Seq_MCF-7_Human1.09665444
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09452291
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08794022
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08712309
120VDR_22108803_ChIP-Seq_LS180_Human1.08531850
121SPI1_23127762_ChIP-Seq_K562_Human1.07700112
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07559084
123GATA1_19941826_ChIP-Seq_K562_Human1.06418302
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.06050979
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05791824
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.05770099
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04685753
128ATF3_27146783_Chip-Seq_COLON_Human1.04156323
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03810841
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02376874
131CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00168616
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99955692
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99207583
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98097736
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94565036
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93352975
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92391432
138GATA3_21867929_ChIP-Seq_CD8_Mouse0.92318779
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.92061195
140* KDM5A_27292631_Chip-Seq_BREAST_Human0.91815273
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91782977
142NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91617584
143SOX2_22085726_ChIP-Seq_NPCs_Mouse0.90025455
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89189328
145* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87029261
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86065429
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85355349
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.84715262
149* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84450551
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84432137
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84052395
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84031147
153AR_21909140_ChIP-Seq_LNCAP_Human0.83376968
154* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82903785
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80752538
156CIITA_25753668_ChIP-Seq_RAJI_Human0.80398659
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80001748
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79203761
159FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78417300
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75341172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.13606960
2MP0005451_abnormal_body_composition3.67891864
3MP0010094_abnormal_chromosome_stability3.47828262
4MP0008877_abnormal_DNA_methylation3.41645722
5MP0001929_abnormal_gametogenesis3.31576489
6MP0008058_abnormal_DNA_repair3.20353852
7MP0003656_abnormal_erythrocyte_physiolo3.16405346
8MP0003698_abnormal_male_reproductive3.10993510
9MP0003693_abnormal_embryo_hatching3.09691421
10MP0008260_abnormal_autophagy3.02672271
11MP0003111_abnormal_nucleus_morphology2.89462755
12MP0003191_abnormal_cellular_cholesterol2.85841468
13MP0005058_abnormal_lysosome_morphology2.78355537
14MP0003172_abnormal_lysosome_physiology2.77048141
15MP0003436_decreased_susceptibility_to2.76032391
16MP0005464_abnormal_platelet_physiology2.61115375
17MP0001986_abnormal_taste_sensitivity2.48791956
18MP0004147_increased_porphyrin_level2.43074466
19MP0003077_abnormal_cell_cycle2.42736948
20MP0004957_abnormal_blastocyst_morpholog2.42335392
21MP0009697_abnormal_copulation2.33851610
22MP0002210_abnormal_sex_determination2.30033352
23MP0005083_abnormal_biliary_tract2.23087839
24MP0003806_abnormal_nucleotide_metabolis2.17452543
25MP0002161_abnormal_fertility/fecundity1.92409792
26MP0008057_abnormal_DNA_replication1.92180743
27MP0009840_abnormal_foam_cell1.90391695
28MP0003303_peritoneal_inflammation1.90065840
29MP0001145_abnormal_male_reproductive1.89504713
30MP0000653_abnormal_sex_gland1.86258709
31MP0001529_abnormal_vocalization1.85761010
32MP0003186_abnormal_redox_activity1.80385619
33MP0003718_maternal_effect1.79908356
34MP0001764_abnormal_homeostasis1.77467713
35MP0005025_abnormal_response_to1.76585213
36MP0006292_abnormal_olfactory_placode1.74992036
37MP0008007_abnormal_cellular_replicative1.74244528
38MP0000685_abnormal_immune_system1.66905208
39MP0006036_abnormal_mitochondrial_physio1.65522715
40MP0002132_abnormal_respiratory_system1.63986313
41MP0002419_abnormal_innate_immunity1.63261283
42MP0002163_abnormal_gland_morphology1.63024404
43MP0003300_gastrointestinal_ulcer1.61931946
44MP0002653_abnormal_ependyma_morphology1.57605827
45MP0000566_synostosis1.55275586
46MP0005000_abnormal_immune_tolerance1.54306168
47MP0002139_abnormal_hepatobiliary_system1.52792157
48MP0005379_endocrine/exocrine_gland_phen1.51539142
49MP0003786_premature_aging1.49723153
50MP0003075_altered_response_to1.49208128
51MP0003646_muscle_fatigue1.48134415
52MP0008932_abnormal_embryonic_tissue1.47934772
53MP0008004_abnormal_stomach_pH1.47085014
54MP0001790_abnormal_immune_system1.46382420
55MP0005387_immune_system_phenotype1.46382420
56MP0000858_altered_metastatic_potential1.46340319
57MP0002736_abnormal_nociception_after1.42542992
58MP0002160_abnormal_reproductive_system1.40807663
59MP0002420_abnormal_adaptive_immunity1.39220211
60MP0001800_abnormal_humoral_immune1.38283565
61MP0001819_abnormal_immune_cell1.36905866
62MP0002148_abnormal_hypersensitivity_rea1.35994034
63MP0002723_abnormal_immune_serum1.35898339
64MP0002405_respiratory_system_inflammati1.33426193
65MP0005636_abnormal_mineral_homeostasis1.32045971
66MP0002166_altered_tumor_susceptibility1.29350162
67MP0001968_abnormal_touch/_nociception1.28810561
68MP0009278_abnormal_bone_marrow1.27610316
69MP0010155_abnormal_intestine_physiology1.24970963
70MP0005389_reproductive_system_phenotype1.24608009
71MP0002452_abnormal_antigen_presenting1.21454429
72MP0000609_abnormal_liver_physiology1.18030878
73MP0001873_stomach_inflammation1.16887617
74MP0002102_abnormal_ear_morphology1.13692235
75MP0001119_abnormal_female_reproductive1.13592327
76MP0003724_increased_susceptibility_to1.12729790
77MP0006276_abnormal_autonomic_nervous1.12726226
78MP0006035_abnormal_mitochondrial_morpho1.12372751
79MP0003183_abnormal_peptide_metabolism1.11563734
80MP0005319_abnormal_enzyme/_coenzyme1.11225754
81MP0001845_abnormal_inflammatory_respons1.10179015
82MP0001545_abnormal_hematopoietic_system1.10048361
83MP0005397_hematopoietic_system_phenotyp1.10048361
84MP0001905_abnormal_dopamine_level1.09877958
85MP0003566_abnormal_cell_adhesion1.09830988
86MP0003879_abnormal_hair_cell1.08121354
87MP0001533_abnormal_skeleton_physiology1.06121626
88MP0002877_abnormal_melanocyte_morpholog1.05609107
89MP0005365_abnormal_bile_salt1.05267250
90MP0002876_abnormal_thyroid_physiology1.04199816
91MP0004947_skin_inflammation1.01222905
92MP0001666_abnormal_nutrient_absorption1.01140536
93MP0003866_abnormal_defecation1.01012733
94MP0005584_abnormal_enzyme/coenzyme_acti1.00935914
95MP0001853_heart_inflammation1.00698418
96MP0001919_abnormal_reproductive_system0.97814576
97MP0002693_abnormal_pancreas_physiology0.97476797
98MP0005166_decreased_susceptibility_to0.96222366
99MP0006082_CNS_inflammation0.94731267
100MP0004233_abnormal_muscle_weight0.94334454
101MP0005671_abnormal_response_to0.93807343
102MP0005501_abnormal_skin_physiology0.92993917
103MP0010329_abnormal_lipoprotein_level0.92985808
104MP0000358_abnormal_cell_content/0.92838831
105MP0003011_delayed_dark_adaptation0.92799787
106MP0003453_abnormal_keratinocyte_physiol0.91630943
107MP0000313_abnormal_cell_death0.90840435
108MP0005645_abnormal_hypothalamus_physiol0.89873264
109MP0005330_cardiomyopathy0.89492630
110MP0002396_abnormal_hematopoietic_system0.88051933
111MP0009333_abnormal_splenocyte_physiolog0.87964571
112MP0009763_increased_sensitivity_to0.86426950
113MP0005646_abnormal_pituitary_gland0.86261336
114MP0002398_abnormal_bone_marrow0.85136476
115MP0003763_abnormal_thymus_physiology0.84994981
116MP0002735_abnormal_chemical_nociception0.84205425
117MP0000598_abnormal_liver_morphology0.82696651
118MP0004381_abnormal_hair_follicle0.81915411
119MP0009379_abnormal_foot_pigmentation0.81461363
120MP0000343_altered_response_to0.81422651
121MP0000465_gastrointestinal_hemorrhage0.81343164
122MP0001915_intracranial_hemorrhage0.81263582
123MP0001835_abnormal_antigen_presentation0.80915378
124MP0002019_abnormal_tumor_incidence0.80248167
125MP0004808_abnormal_hematopoietic_stem0.79969230
126MP0001661_extended_life_span0.78134598
127MP0002332_abnormal_exercise_endurance0.77663773
128MP0003221_abnormal_cardiomyocyte_apopto0.76630840
129MP0008789_abnormal_olfactory_epithelium0.76486730
130MP0005085_abnormal_gallbladder_physiolo0.76314959
131MP0009643_abnormal_urine_homeostasis0.74882374
132MP0009764_decreased_sensitivity_to0.74219146
133MP0005075_abnormal_melanosome_morpholog0.73257079
134MP0005408_hypopigmentation0.72786932
135MP0005670_abnormal_white_adipose0.72504052
136MP0001984_abnormal_olfaction0.72428684
137MP0003699_abnormal_female_reproductive0.71196599
138MP0002138_abnormal_hepatobiliary_system0.70706704
139MP0009785_altered_susceptibility_to0.69700818
140MP0003787_abnormal_imprinting0.69627985
141MP0002429_abnormal_blood_cell0.68192164
142MP0000015_abnormal_ear_pigmentation0.67821198
143MP0001348_abnormal_lacrimal_gland0.67153615
144MP0000350_abnormal_cell_proliferation0.66989377
145MP0008875_abnormal_xenobiotic_pharmacok0.66347878
146MP0003880_abnormal_central_pattern0.64886622
147MP0000689_abnormal_spleen_morphology0.64458819
148MP0002938_white_spotting0.63700611
149MP0005084_abnormal_gallbladder_morpholo0.63562732
150MP0000678_abnormal_parathyroid_gland0.62323778
151MP0002638_abnormal_pupillary_reflex0.59391633
152MP0002722_abnormal_immune_system0.58450720
153MP0010386_abnormal_urinary_bladder0.58279311
154MP0001730_embryonic_growth_arrest0.56908262
155MP0005266_abnormal_metabolism0.55561307
156MP0000490_abnormal_crypts_of0.55557947
157MP0000703_abnormal_thymus_morphology0.53452495
158MP0004782_abnormal_surfactant_physiolog0.52315896
159MP0005376_homeostasis/metabolism_phenot0.51927941
160MP0000716_abnormal_immune_system0.50109090
161MP0005360_urolithiasis0.49719445
162MP0008872_abnormal_physiological_respon0.48682150
163MP0008469_abnormal_protein_level0.48483993

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.45704779
2Absent/shortened dynein arms (HP:0200106)6.45704779
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.98012532
4Abnormal respiratory epithelium morphology (HP:0012253)5.00801238
5Abnormal respiratory motile cilium morphology (HP:0005938)5.00801238
6Hypochromic microcytic anemia (HP:0004840)4.60881142
7Abnormal respiratory motile cilium physiology (HP:0012261)4.51229231
8Chronic bronchitis (HP:0004469)4.15554241
9Abnormality of the heme biosynthetic pathway (HP:0010472)4.10294577
10Cholelithiasis (HP:0001081)4.06334181
11Infertility (HP:0000789)3.83758517
12Rhinitis (HP:0012384)3.79352391
13Abnormal gallbladder morphology (HP:0012437)3.66288654
14Deep venous thrombosis (HP:0002625)3.61540568
15Abnormal ciliary motility (HP:0012262)3.61155911
16Petechiae (HP:0000967)3.39796957
17Acute necrotizing encephalopathy (HP:0006965)3.33539066
18Abnormal spermatogenesis (HP:0008669)3.24865748
19Birth length less than 3rd percentile (HP:0003561)3.24641163
20Hypoplasia of the capital femoral epiphysis (HP:0003090)3.22063742
21Hepatocellular necrosis (HP:0001404)3.17547421
22Hypochromic anemia (HP:0001931)3.12457471
23Polycythemia (HP:0001901)3.11443088
24Mitochondrial inheritance (HP:0001427)3.09384623
25Reticulocytosis (HP:0001923)3.08610506
26Abnormal mitochondria in muscle tissue (HP:0008316)3.05916382
27Purpura (HP:0000979)2.96810506
28Nasal polyposis (HP:0100582)2.94465755
29Aplastic anemia (HP:0001915)2.91600375
30Increased CSF lactate (HP:0002490)2.90748942
31Microcytic anemia (HP:0001935)2.87814517
32Prolonged bleeding time (HP:0003010)2.83576251
33Abnormality of the gallbladder (HP:0005264)2.77976292
34Acute encephalopathy (HP:0006846)2.72301120
35Hepatic necrosis (HP:0002605)2.71266735
36Nephronophthisis (HP:0000090)2.70699204
37Joint hemorrhage (HP:0005261)2.67847911
38Bronchitis (HP:0012387)2.67475539
39Increased serum pyruvate (HP:0003542)2.66062184
40Abnormality of glycolysis (HP:0004366)2.66062184
41Gingival bleeding (HP:0000225)2.63213373
42Abnormality of macrophages (HP:0004311)2.62102119
43Vertebral compression fractures (HP:0002953)2.60186153
44Bronchiectasis (HP:0002110)2.57464539
45Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.57175242
46Absent epiphyses (HP:0010577)2.57175242
47Abnormal hemoglobin (HP:0011902)2.56613394
48Medial flaring of the eyebrow (HP:0010747)2.55806737
49Eczematoid dermatitis (HP:0000976)2.55126081
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52205970
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52205970
52Increased serum ferritin (HP:0003281)2.51608887
53Epistaxis (HP:0000421)2.49654097
54Progressive macrocephaly (HP:0004481)2.49214011
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.46562281
56Recurrent abscess formation (HP:0002722)2.46041286
57Systemic lupus erythematosus (HP:0002725)2.44998892
58Chronic obstructive pulmonary disease (HP:0006510)2.43532505
59Obstructive lung disease (HP:0006536)2.43532505
60Rhabdomyolysis (HP:0003201)2.42787865
61Cholecystitis (HP:0001082)2.40190295
62Abnormal gallbladder physiology (HP:0012438)2.40190295
63Abnormal hair whorl (HP:0010721)2.38800761
64Increased serum lactate (HP:0002151)2.37982183
65Ragged-red muscle fibers (HP:0003200)2.35573724
66Gastrointestinal infarctions (HP:0005244)2.35394978
67Recurrent bacterial skin infections (HP:0005406)2.34469803
68Abnormal number of erythroid precursors (HP:0012131)2.34233143
69Oral leukoplakia (HP:0002745)2.33756274
70Hypertensive crisis (HP:0100735)2.32001123
71Tubulointerstitial nephritis (HP:0001970)2.29944711
72Abnormality of iron homeostasis (HP:0011031)2.28566162
73Irregular epiphyses (HP:0010582)2.28515967
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.25970114
75Lactic acidosis (HP:0003128)2.25894735
76Orthostatic hypotension (HP:0001278)2.25692032
77Impulsivity (HP:0100710)2.25397603
78Acute hepatic failure (HP:0006554)2.24017314
79Gastrointestinal inflammation (HP:0004386)2.20909808
80Poikilocytosis (HP:0004447)2.19009034
81Urticaria (HP:0001025)2.16638250
82Myopathic facies (HP:0002058)2.16340319
83Abnormality of the nasal mucosa (HP:0000433)2.15312728
84Myositis (HP:0100614)2.14542617
85Menorrhagia (HP:0000132)2.14377478
86Pancreatic fibrosis (HP:0100732)2.12880630
87Azoospermia (HP:0000027)2.12562836
88Molar tooth sign on MRI (HP:0002419)2.11729272
89Abnormality of midbrain morphology (HP:0002418)2.11729272
90Prolonged partial thromboplastin time (HP:0003645)2.11665513
91Toxemia of pregnancy (HP:0100603)2.11601656
92Abnormality of the preputium (HP:0100587)2.10908083
93Hemorrhage of the eye (HP:0011885)2.10237040
94Abnormality of cells of the erythroid lineage (HP:0012130)2.09922205
95Hypertriglyceridemia (HP:0002155)2.08486596
96Optic disc pallor (HP:0000543)2.06721159
97Inflammation of the large intestine (HP:0002037)2.05270653
98Abnormality of the labia minora (HP:0012880)2.03861707
99Recurrent sinusitis (HP:0011108)2.03738285
100Degeneration of anterior horn cells (HP:0002398)2.03692966
101Abnormality of the anterior horn cell (HP:0006802)2.03692966
102Abnormality of glycolipid metabolism (HP:0010969)2.03538303
103Abnormality of liposaccharide metabolism (HP:0010968)2.03538303
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.03538303
105Aplasia/Hypoplasia of the uvula (HP:0010293)2.03320803
106Fatigue (HP:0012378)2.02265365
107Reticulocytopenia (HP:0001896)2.00836403
108Orchitis (HP:0100796)2.00787859
109Recurrent gram-negative bacterial infections (HP:0005420)2.00169006
1103-Methylglutaconic aciduria (HP:0003535)1.99152658
111Ileus (HP:0002595)1.98712940
112Cleft eyelid (HP:0000625)1.98599692
113Slow saccadic eye movements (HP:0000514)1.97832267
114Hepatosplenomegaly (HP:0001433)1.97379854
115Acanthocytosis (HP:0001927)1.97313905
116Type 2 muscle fiber atrophy (HP:0003554)1.96653363
117Abnormality of complement system (HP:0005339)1.95401614
118Pancytopenia (HP:0001876)1.95067405
119True hermaphroditism (HP:0010459)1.95028756
120Exercise-induced myalgia (HP:0003738)1.93804331
121Recurrent viral infections (HP:0004429)1.92558946
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91813875
123Increased IgM level (HP:0003496)1.90066407
124Poor suck (HP:0002033)1.89068956
125Hyperbilirubinemia (HP:0002904)1.88719242
12611 pairs of ribs (HP:0000878)1.88516327
127Amyloidosis (HP:0011034)1.88302891
128Abnormality of the common coagulation pathway (HP:0010990)1.88223646
129Paralysis (HP:0003470)1.87782575
130Abnormality of transition element cation homeostasis (HP:0011030)1.87698509
131Gastrointestinal dysmotility (HP:0002579)1.87078904
132Pustule (HP:0200039)1.87001496
133Sloping forehead (HP:0000340)1.86818693
134Microvesicular hepatic steatosis (HP:0001414)1.86117169
135Increased IgE level (HP:0003212)1.85560007
136Impaired platelet aggregation (HP:0003540)1.85260306
137Abnormal platelet function (HP:0011869)1.85260306
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84853222
139Patellar aplasia (HP:0006443)1.83518060
140Recurrent fungal infections (HP:0002841)1.83241268
141Chromsome breakage (HP:0040012)1.83004991
142Exercise intolerance (HP:0003546)1.81754011
143Cerebral edema (HP:0002181)1.81344842
144Horseshoe kidney (HP:0000085)1.80975717
145Abnormality of the ileum (HP:0001549)1.80817763
146Axonal loss (HP:0003447)1.80735308
147Respiratory difficulties (HP:0002880)1.80194066
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79590554
149Dysostosis multiplex (HP:0000943)1.79159780
150Myoglobinuria (HP:0002913)1.79080308
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78910661
152Abnormality of pyrimidine metabolism (HP:0004353)1.78415250
153Pancreatic cysts (HP:0001737)1.78390472
154Nephrogenic diabetes insipidus (HP:0009806)1.78139839
155Seborrheic dermatitis (HP:0001051)1.77847436
156Abnormality of chromosome stability (HP:0003220)1.77759641
157Secondary amenorrhea (HP:0000869)1.77485144
158Cerebral hypomyelination (HP:0006808)1.77255571
159Hyperventilation (HP:0002883)1.76652478
160Glomerulonephritis (HP:0000099)1.76409769
161Unsteady gait (HP:0002317)1.76188383
162Abnormal lung lobation (HP:0002101)1.76067393
163Complement deficiency (HP:0004431)1.76067051
164Meningitis (HP:0001287)1.76030995
165Meckel diverticulum (HP:0002245)1.75838834
166Brushfield spots (HP:0001088)1.75447856
167Gait imbalance (HP:0002141)1.75269504
168Encephalitis (HP:0002383)1.74990417
169Increased connective tissue (HP:0009025)1.74984818
170Congenital primary aphakia (HP:0007707)1.74911915
171Panhypogammaglobulinemia (HP:0003139)1.74258917
172Distal lower limb muscle weakness (HP:0009053)1.74247674
173Female pseudohermaphroditism (HP:0010458)1.74108866
174Reduced antithrombin III activity (HP:0001976)1.74024435
175Abnormal platelet volume (HP:0011876)1.73928533
176Cellulitis (HP:0100658)1.73687798
177Respiratory failure (HP:0002878)1.73619422
178Recurrent skin infections (HP:0001581)1.73136438
179Abnormality of reticulocytes (HP:0004312)1.72941723
180Abnormality of the renal medulla (HP:0100957)1.71839811
181Postaxial foot polydactyly (HP:0001830)1.71706150
182Pulmonary fibrosis (HP:0002206)1.71511503
183Recurrent otitis media (HP:0000403)1.71120036
184Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71016138
185Type I transferrin isoform profile (HP:0003642)1.70993430
186Elevated erythrocyte sedimentation rate (HP:0003565)1.70007452
187Chest pain (HP:0100749)1.69976973
188Rough bone trabeculation (HP:0100670)1.69435132
189Colitis (HP:0002583)1.68858727
190Xanthomatosis (HP:0000991)1.68778949
191Joint swelling (HP:0001386)1.67953631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK13.80061325
2BUB13.65844886
3PDK43.46964427
4PDK33.46964427
5ERN13.46478637
6CASK3.13295959
7CCNB13.09049889
8EIF2AK12.96817619
9SMG12.94730305
10VRK22.84919307
11STK162.74909940
12MAP2K32.58259008
13RIPK42.52089962
14BRSK22.50717049
15PRPF4B2.39543259
16TAOK22.32401508
17PASK2.30763129
18PLK42.27774121
19MAP3K32.27423433
20ACVR1B2.24346958
21TRIB32.22356505
22GRK62.21005473
23TLK12.17143046
24BMPR1B2.05414473
25VRK12.04637823
26TAOK12.03998909
27PRKD31.97313110
28SIK31.95786269
29BRSK11.93467128
30CDC71.92361357
31WEE11.91278637
32PDK21.81715594
33MUSK1.76971159
34PBK1.76626871
35CDK81.75280303
36BRAF1.73122569
37PIM21.72930087
38MAP2K71.66906890
39SRPK11.62794936
40TESK21.45573337
41TYK21.41593542
42TNK21.37997171
43MAP3K11.37288669
44SIK11.35659386
45TSSK61.35329923
46EPHB11.31950813
47DYRK21.22669404
48EIF2AK31.22660305
49PAK41.22131221
50PLK11.20546538
51PLK31.18865105
52TTK1.18723991
53SCYL21.15575711
54NME11.15336030
55CHEK21.14573109
56FGFR41.10999009
57CDK121.10010423
58MAP3K121.05744419
59DYRK31.04581977
60MST1R1.03282306
61LRRK21.01826233
62NEK21.01486484
63EPHA21.01259889
64AURKA0.98160329
65ARAF0.96102150
66ADRBK20.94455617
67ATR0.94363202
68TXK0.92108412
69FGR0.89120790
70KDR0.87656504
71MAP3K80.86695362
72BCKDK0.83697761
73BLK0.82176052
74STK38L0.80424997
75NME20.79876497
76MARK30.79202437
77MAP4K10.78662022
78PTK60.77294349
79CLK10.76334380
80MAPK130.75420850
81CSK0.74607019
82IRAK10.74123591
83HIPK20.74032736
84FES0.72387019
85PLK20.70050474
86ZAK0.69895768
87AURKB0.69616135
88TGFBR10.69399661
89MAPK110.68711218
90NEK10.65821999
91STK380.65113970
92PDPK10.64804409
93BTK0.63750384
94PIM10.62064856
95PRKD20.62047694
96DAPK10.61712571
97KSR20.60258916
98BMX0.59887301
99HCK0.59655032
100ILK0.59226516
101CSNK2A10.58011274
102MAPKAPK20.57804043
103EIF2AK20.57664935
104GRK50.57356086
105PKN20.55696869
106SYK0.54808960
107ABL20.53217878
108MAP4K20.53170255
109RAF10.53109858
110DYRK1B0.52728522
111FLT30.51200289
112CHEK10.50747902
113LMTK20.50527009
114MKNK10.49098652
115MST40.48807750
116CDK190.48624532
117LYN0.46367527
118MKNK20.46263610
119MAP3K50.46248574
120CDK70.46165893
121RIPK10.45861952
122JAK30.44475652
123PDK10.44393707
124STK40.43979084
125NLK0.43278583
126CDK40.42567797
127IKBKE0.41530062
128TEC0.41414514
129ATM0.41194028
130PRKCG0.40002901
131MATK0.39622986
132MARK20.39332888
133LIMK10.38594807
134CSNK2A20.38402458
135TTN0.38365638
136TGFBR20.37227080
137BCR0.36867897
138TAOK30.36776002
139MAP3K110.36656226
140RPS6KB10.34185602
141JAK20.34072190
142IRAK30.33944833
143CDK90.32686282
144NEK90.32581675
145ICK0.31029708
146BMPR20.30511599
147PTK2B0.30110578
148MAP3K60.29044239
149STK240.28597084
150STK100.28589205
151CSF1R0.28130620
152IRAK40.28044226
153PAK10.27944919
154WNK40.27281129
155AKT30.27122121
156ZAP700.26942826
157MAPKAPK50.26281695
158MYLK0.26137221
159IKBKB0.25930399
160MAPK40.25819896
161IRAK20.24793014
162CDK180.24765227
163RPS6KA40.24179705
164CDK20.23595107
165PRKCI0.23541621
166TBK10.23032993

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06198844
2* Proteasome_Homo sapiens_hsa030504.02671472
3Mismatch repair_Homo sapiens_hsa034303.10827626
4Base excision repair_Homo sapiens_hsa034102.97844649
5RNA polymerase_Homo sapiens_hsa030202.91903421
6Homologous recombination_Homo sapiens_hsa034402.78755831
7Pyrimidine metabolism_Homo sapiens_hsa002402.62768682
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49760766
9Basal transcription factors_Homo sapiens_hsa030222.42493720
10Oxidative phosphorylation_Homo sapiens_hsa001902.40609655
11Nucleotide excision repair_Homo sapiens_hsa034202.28431325
12Ribosome_Homo sapiens_hsa030102.19082270
13Protein export_Homo sapiens_hsa030602.18760157
14Fanconi anemia pathway_Homo sapiens_hsa034602.17416434
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.09835886
16Parkinsons disease_Homo sapiens_hsa050122.06977750
17Cell cycle_Homo sapiens_hsa041102.02870966
18Spliceosome_Homo sapiens_hsa030402.02718564
19RNA transport_Homo sapiens_hsa030132.02032156
20Huntingtons disease_Homo sapiens_hsa050161.88346543
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.80142062
22One carbon pool by folate_Homo sapiens_hsa006701.77606442
23Purine metabolism_Homo sapiens_hsa002301.73881877
24Non-homologous end-joining_Homo sapiens_hsa034501.72824967
25RNA degradation_Homo sapiens_hsa030181.71200208
26Fatty acid elongation_Homo sapiens_hsa000621.70318059
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68520606
28Pyruvate metabolism_Homo sapiens_hsa006201.66906821
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58563036
30Vitamin B6 metabolism_Homo sapiens_hsa007501.53848544
31Selenocompound metabolism_Homo sapiens_hsa004501.45657661
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.45024055
33Collecting duct acid secretion_Homo sapiens_hsa049661.43600970
34Complement and coagulation cascades_Homo sapiens_hsa046101.42541820
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38067091
36Acute myeloid leukemia_Homo sapiens_hsa052211.36289909
37Malaria_Homo sapiens_hsa051441.35544183
38Staphylococcus aureus infection_Homo sapiens_hsa051501.33132317
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25450247
40Non-small cell lung cancer_Homo sapiens_hsa052231.24247775
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23603463
42Shigellosis_Homo sapiens_hsa051311.22613159
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18692052
44Alzheimers disease_Homo sapiens_hsa050101.15040531
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.07908428
46Fatty acid metabolism_Homo sapiens_hsa012121.06227905
47Osteoclast differentiation_Homo sapiens_hsa043801.05260080
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02211248
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02057489
50Pancreatic cancer_Homo sapiens_hsa052121.01054561
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00520195
52Pentose phosphate pathway_Homo sapiens_hsa000300.99120697
53Leishmaniasis_Homo sapiens_hsa051400.97811460
54Linoleic acid metabolism_Homo sapiens_hsa005910.97277743
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94121677
56Apoptosis_Homo sapiens_hsa042100.91417488
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89327352
58Tuberculosis_Homo sapiens_hsa051520.89021473
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.88634934
60mRNA surveillance pathway_Homo sapiens_hsa030150.88314316
61Influenza A_Homo sapiens_hsa051640.88292647
62Epstein-Barr virus infection_Homo sapiens_hsa051690.88182042
63Folate biosynthesis_Homo sapiens_hsa007900.87473711
64Carbon metabolism_Homo sapiens_hsa012000.85169440
65Oocyte meiosis_Homo sapiens_hsa041140.84919023
66Bladder cancer_Homo sapiens_hsa052190.83856546
67Biosynthesis of amino acids_Homo sapiens_hsa012300.82492309
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82407437
69Salmonella infection_Homo sapiens_hsa051320.82232197
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81967318
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81948566
72Metabolic pathways_Homo sapiens_hsa011000.81058591
73Propanoate metabolism_Homo sapiens_hsa006400.81030123
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79551569
75Lysosome_Homo sapiens_hsa041420.78735983
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78643322
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77669276
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.77442293
79Endocytosis_Homo sapiens_hsa041440.75674921
80Graft-versus-host disease_Homo sapiens_hsa053320.75213848
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75034486
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.73539295
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.73301308
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.72474403
85Systemic lupus erythematosus_Homo sapiens_hsa053220.72177247
86Glutathione metabolism_Homo sapiens_hsa004800.71728879
87Prion diseases_Homo sapiens_hsa050200.71685619
88Hematopoietic cell lineage_Homo sapiens_hsa046400.71485204
89Viral myocarditis_Homo sapiens_hsa054160.70069624
90Vibrio cholerae infection_Homo sapiens_hsa051100.70002107
91B cell receptor signaling pathway_Homo sapiens_hsa046620.69207554
92Arginine and proline metabolism_Homo sapiens_hsa003300.68931849
93Thyroid cancer_Homo sapiens_hsa052160.67194794
94Peroxisome_Homo sapiens_hsa041460.67004518
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65945397
96Hepatitis C_Homo sapiens_hsa051600.65814033
97Tyrosine metabolism_Homo sapiens_hsa003500.63932297
98African trypanosomiasis_Homo sapiens_hsa051430.62997563
99Fat digestion and absorption_Homo sapiens_hsa049750.62616541
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60959381
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59967182
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59150138
103T cell receptor signaling pathway_Homo sapiens_hsa046600.59122873
104Hepatitis B_Homo sapiens_hsa051610.57716825
105Synaptic vesicle cycle_Homo sapiens_hsa047210.57656710
106p53 signaling pathway_Homo sapiens_hsa041150.56928770
107PPAR signaling pathway_Homo sapiens_hsa033200.55947051
108Insulin signaling pathway_Homo sapiens_hsa049100.53339489
109Pertussis_Homo sapiens_hsa051330.53046580
110Fatty acid biosynthesis_Homo sapiens_hsa000610.52277661
111Arginine biosynthesis_Homo sapiens_hsa002200.52134704
112Fructose and mannose metabolism_Homo sapiens_hsa000510.52120487
113Toxoplasmosis_Homo sapiens_hsa051450.51623124
114Arachidonic acid metabolism_Homo sapiens_hsa005900.50417583
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48912491
116Antigen processing and presentation_Homo sapiens_hsa046120.46782795
117Allograft rejection_Homo sapiens_hsa053300.46594000
118N-Glycan biosynthesis_Homo sapiens_hsa005100.45216014
119Herpes simplex infection_Homo sapiens_hsa051680.42590231
120Legionellosis_Homo sapiens_hsa051340.41332830
121Rheumatoid arthritis_Homo sapiens_hsa053230.40609950
122Other glycan degradation_Homo sapiens_hsa005110.39824692
123Primary immunodeficiency_Homo sapiens_hsa053400.38470747
124Galactose metabolism_Homo sapiens_hsa000520.37913498
125Type I diabetes mellitus_Homo sapiens_hsa049400.36501566
126Sulfur relay system_Homo sapiens_hsa041220.36316160
127Phagosome_Homo sapiens_hsa041450.35312255
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.35233630
129Cardiac muscle contraction_Homo sapiens_hsa042600.31853912
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30565802
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30172765
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28079718
133Measles_Homo sapiens_hsa051620.28022363
134Fatty acid degradation_Homo sapiens_hsa000710.27513599
135Ether lipid metabolism_Homo sapiens_hsa005650.26937344
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24341067
137Phenylalanine metabolism_Homo sapiens_hsa003600.23990390
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.23675767
139Viral carcinogenesis_Homo sapiens_hsa052030.23623418
140Alcoholism_Homo sapiens_hsa050340.23541224
141Regulation of autophagy_Homo sapiens_hsa041400.22816712
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22743281
143Sulfur metabolism_Homo sapiens_hsa009200.22543860
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20019395
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19474036
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19192412
147Autoimmune thyroid disease_Homo sapiens_hsa053200.19174359
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17191279

Most similar genes based on co-expression Upload to Enrichr

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