PSMD14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.25649381
2cullin deneddylation (GO:0010388)4.88838965
3* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.87353351
4* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.62945348
5purine nucleobase biosynthetic process (GO:0009113)4.62005261
6* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.56913653
7protein deneddylation (GO:0000338)4.54966645
8formation of translation preinitiation complex (GO:0001731)4.52729856
9* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.50288037
10nucleobase biosynthetic process (GO:0046112)4.45445282
11* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.42961131
12* negative regulation of ligase activity (GO:0051352)4.42961131
13* regulation of cellular amino acid metabolic process (GO:0006521)4.36989726
14* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.31293228
15* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.24119627
16* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.24119627
17* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.21065773
18* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.21065773
19* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.21065773
20histone exchange (GO:0043486)4.15970467
21DNA strand elongation involved in DNA replication (GO:0006271)4.14517262
22maturation of SSU-rRNA (GO:0030490)4.14315565
23DNA double-strand break processing (GO:0000729)4.13229274
24* signal transduction involved in DNA damage checkpoint (GO:0072422)4.11422737
25* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.11422737
26* signal transduction involved in cell cycle checkpoint (GO:0072395)4.07044977
27DNA replication initiation (GO:0006270)4.06447134
28* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.03005270
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01708430
30* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.99451970
31telomere maintenance via semi-conservative replication (GO:0032201)3.99368534
327-methylguanosine mRNA capping (GO:0006370)3.96953504
33ribosome assembly (GO:0042255)3.92163000
34RNA capping (GO:0036260)3.90697476
357-methylguanosine RNA capping (GO:0009452)3.90697476
36DNA strand elongation (GO:0022616)3.90696693
37ribosomal small subunit assembly (GO:0000028)3.88637148
38DNA replication checkpoint (GO:0000076)3.87844665
39protein neddylation (GO:0045116)3.85878605
40* positive regulation of ligase activity (GO:0051351)3.84697476
41ribosome biogenesis (GO:0042254)3.82567393
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.80517857
43ribosomal large subunit biogenesis (GO:0042273)3.76197628
44CENP-A containing nucleosome assembly (GO:0034080)3.76194224
45termination of RNA polymerase III transcription (GO:0006386)3.75683167
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.75683167
47* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.73911346
48mitotic metaphase plate congression (GO:0007080)3.72285933
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71906601
50ATP synthesis coupled proton transport (GO:0015986)3.71906601
51protein localization to kinetochore (GO:0034501)3.70507243
52* cell cycle G1/S phase transition (GO:0044843)3.69375745
53* G1/S transition of mitotic cell cycle (GO:0000082)3.69375745
54ribonucleoprotein complex biogenesis (GO:0022613)3.68184492
55telomere maintenance via recombination (GO:0000722)3.66866380
56DNA ligation (GO:0006266)3.65053713
57establishment of viral latency (GO:0019043)3.63073671
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62298882
59chromatin remodeling at centromere (GO:0031055)3.59577028
60DNA damage response, detection of DNA damage (GO:0042769)3.58334020
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.57266104
62* regulation of ubiquitin-protein transferase activity (GO:0051438)3.56794660
63transcription-coupled nucleotide-excision repair (GO:0006283)3.56245824
64rRNA modification (GO:0000154)3.56050497
65establishment of integrated proviral latency (GO:0075713)3.46581332
66rRNA processing (GO:0006364)3.46419787
67deoxyribonucleotide biosynthetic process (GO:0009263)3.46331794
68spliceosomal snRNP assembly (GO:0000387)3.45858542
69* regulation of ligase activity (GO:0051340)3.43477131
70pseudouridine synthesis (GO:0001522)3.41617410
71termination of RNA polymerase I transcription (GO:0006363)3.40361456
72* positive regulation of cell cycle arrest (GO:0071158)3.40286942
73mitotic recombination (GO:0006312)3.39318706
74ribosomal small subunit biogenesis (GO:0042274)3.36366133
75regulation of mitotic spindle checkpoint (GO:1903504)3.35206597
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35206597
77* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.35166538
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34986036
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34329579
80mitotic sister chromatid segregation (GO:0000070)3.34298852
81nucleobase-containing small molecule interconversion (GO:0015949)3.32611008
82rRNA metabolic process (GO:0016072)3.32224755
83transcription from RNA polymerase I promoter (GO:0006360)3.31357636
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31259850
85maturation of 5.8S rRNA (GO:0000460)3.31053881
86DNA catabolic process, exonucleolytic (GO:0000738)3.30702768
87spindle checkpoint (GO:0031577)3.30379047
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.27480393
89IMP biosynthetic process (GO:0006188)3.26608480
90cellular component biogenesis (GO:0044085)3.26537338
91DNA deamination (GO:0045006)3.25474147
92mitotic spindle checkpoint (GO:0071174)3.20732329
93viral mRNA export from host cell nucleus (GO:0046784)3.20686558
94telomere maintenance via telomere lengthening (GO:0010833)3.18056222
95kinetochore organization (GO:0051383)3.17595010
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.16397968
97negative regulation of sister chromatid segregation (GO:0033046)3.16397968
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16397968
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16397968
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16397968
101chaperone-mediated protein transport (GO:0072321)3.16192261
102regulation of centriole replication (GO:0046599)3.15697338
103establishment of protein localization to mitochondrion (GO:0072655)3.15344457
104* regulation of cellular amine metabolic process (GO:0033238)3.15318110
105translation (GO:0006412)3.13571164
106negative regulation of chromosome segregation (GO:0051985)3.12996493
107replication fork processing (GO:0031297)3.12616992
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12461249
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12461249
110spliceosomal complex assembly (GO:0000245)3.11876271
111regulation of mitochondrial translation (GO:0070129)3.11791110
112sister chromatid segregation (GO:0000819)3.11144779
113de novo protein folding (GO:0006458)3.10895934
114protein targeting to mitochondrion (GO:0006626)3.10252534
1152-deoxyribonucleotide biosynthetic process (GO:0009265)3.09891527
116deoxyribose phosphate biosynthetic process (GO:0046385)3.09891527
117DNA replication-independent nucleosome assembly (GO:0006336)3.09346793
118DNA replication-independent nucleosome organization (GO:0034724)3.09346793
119metaphase plate congression (GO:0051310)3.08122935
120protein localization to chromosome, centromeric region (GO:0071459)3.08069926
121DNA unwinding involved in DNA replication (GO:0006268)3.07908275
122DNA replication-dependent nucleosome organization (GO:0034723)3.07249770
123DNA replication-dependent nucleosome assembly (GO:0006335)3.07249770
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06544636
125* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.05215990
126establishment of chromosome localization (GO:0051303)3.05102562
127transcription initiation from RNA polymerase I promoter (GO:0006361)3.04216011
128transcription elongation from RNA polymerase II promoter (GO:0006368)3.04017689
129kinetochore assembly (GO:0051382)3.03351214
130IMP metabolic process (GO:0046040)3.00608760
131protein K6-linked ubiquitination (GO:0085020)3.00315697
132mitotic spindle assembly checkpoint (GO:0007094)2.98940253
133regulation of chromosome segregation (GO:0051983)2.97324620
134spindle assembly checkpoint (GO:0071173)2.96696707
135protein localization to mitochondrion (GO:0070585)2.96502804
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93018797
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93018797
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.92829711
139* negative regulation of protein ubiquitination (GO:0031397)2.92674064
140histone mRNA metabolic process (GO:0008334)2.90704683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60363821
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.74630018
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.34100577
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.12655269
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.09846610
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80598768
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67821859
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.62494169
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.52023947
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39404746
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33745152
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13034336
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05861963
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03289692
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98781611
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91504448
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83859572
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79771172
19VDR_23849224_ChIP-Seq_CD4+_Human2.74265001
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54750665
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50627261
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49828469
23DCP1A_22483619_ChIP-Seq_HELA_Human2.44956971
24ELK1_19687146_ChIP-ChIP_HELA_Human2.40426483
25XRN2_22483619_ChIP-Seq_HELA_Human2.36328958
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35992703
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35732703
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34195006
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.29526103
30FOXP3_21729870_ChIP-Seq_TREG_Human2.19358748
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17830964
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.14744702
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10216432
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07808228
35* GABP_19822575_ChIP-Seq_HepG2_Human2.01714496
36TTF2_22483619_ChIP-Seq_HELA_Human1.99476445
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.98689899
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96023703
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95966503
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93603444
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93440770
42AR_21909140_ChIP-Seq_LNCAP_Human1.90646503
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87445600
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85600169
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79034635
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78423448
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74952561
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70797173
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60537150
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55130007
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51579975
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48989869
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.46177022
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42280779
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40378339
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.39611630
57VDR_22108803_ChIP-Seq_LS180_Human1.37006630
58KDM5A_27292631_Chip-Seq_BREAST_Human1.25188640
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24722089
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21816780
61ZNF274_21170338_ChIP-Seq_K562_Hela1.20534886
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19076200
63MYC_18940864_ChIP-ChIP_HL60_Human1.18400502
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.17638773
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16630555
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15897924
67* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12527185
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11825285
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11423427
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08396166
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07207533
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06842815
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.06838475
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05055864
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03751238
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03589600
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01332712
78CIITA_25753668_ChIP-Seq_RAJI_Human1.01254109
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99389561
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.99116885
81TFEB_21752829_ChIP-Seq_HELA_Human0.97701897
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97009802
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95650647
84IGF1R_20145208_ChIP-Seq_DFB_Human0.93558747
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91908797
86IRF1_19129219_ChIP-ChIP_H3396_Human0.90735175
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88175638
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88071966
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86786967
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86075296
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85575167
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85319833
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83673608
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83360332
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81481202
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80973734
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80888820
98EWS_26573619_Chip-Seq_HEK293_Human0.80588709
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.80424186
100P300_19829295_ChIP-Seq_ESCs_Human0.75417267
101* NANOG_16153702_ChIP-ChIP_HESCs_Human0.74271757
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74255814
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72949954
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72743258
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.72667867
106TAF15_26573619_Chip-Seq_HEK293_Human0.72450578
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72441753
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72010860
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70029753
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69973275
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68864513
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.68765302
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.67973074
114FUS_26573619_Chip-Seq_HEK293_Human0.67935765
115SPI1_23547873_ChIP-Seq_NB4_Human0.67858867
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67388476
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66785049
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.65132707
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.65055958
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.64590408
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64375348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.54224662
2MP0004957_abnormal_blastocyst_morpholog4.67773095
3MP0010094_abnormal_chromosome_stability4.34304074
4MP0003111_abnormal_nucleus_morphology3.89215734
5MP0008057_abnormal_DNA_replication3.76658160
6MP0003077_abnormal_cell_cycle3.71225445
7MP0008058_abnormal_DNA_repair3.51412588
8MP0008932_abnormal_embryonic_tissue3.19623133
9MP0003123_paternal_imprinting2.87933817
10MP0003806_abnormal_nucleotide_metabolis2.69367121
11MP0003718_maternal_effect2.66962094
12MP0003786_premature_aging2.47207425
13MP0008007_abnormal_cellular_replicative2.45835494
14MP0001529_abnormal_vocalization2.22223735
15MP0008877_abnormal_DNA_methylation2.11523224
16MP0001730_embryonic_growth_arrest1.99137899
17MP0003186_abnormal_redox_activity1.96090774
18MP0006035_abnormal_mitochondrial_morpho1.90197661
19MP0000350_abnormal_cell_proliferation1.81332920
20MP0002938_white_spotting1.78055702
21MP0001293_anophthalmia1.74816526
22MP0006072_abnormal_retinal_apoptosis1.71583957
23MP0001905_abnormal_dopamine_level1.68426860
24MP0009697_abnormal_copulation1.66166806
25MP0006036_abnormal_mitochondrial_physio1.64117215
26MP0009333_abnormal_splenocyte_physiolog1.49390184
27MP0002396_abnormal_hematopoietic_system1.48503289
28MP0003121_genomic_imprinting1.43968447
29MP0008260_abnormal_autophagy1.43122098
30MP0003315_abnormal_perineum_morphology1.37424623
31MP0003937_abnormal_limbs/digits/tail_de1.36253537
32MP0002160_abnormal_reproductive_system1.35648800
33MP0003880_abnormal_central_pattern1.34002471
34MP0009379_abnormal_foot_pigmentation1.33956199
35MP0002163_abnormal_gland_morphology1.30838046
36MP0001697_abnormal_embryo_size1.30578411
37MP0006276_abnormal_autonomic_nervous1.30287260
38MP0002736_abnormal_nociception_after1.24818647
39MP0010352_gastrointestinal_tract_polyps1.23358647
40MP0002080_prenatal_lethality1.23085981
41MP0000372_irregular_coat_pigmentation1.22655481
42MP0001542_abnormal_bone_strength1.20765544
43MP0000358_abnormal_cell_content/1.20553860
44MP0001672_abnormal_embryogenesis/_devel1.19632481
45MP0005380_embryogenesis_phenotype1.19632481
46MP0006292_abnormal_olfactory_placode1.19394915
47MP0000313_abnormal_cell_death1.18672124
48MP0000647_abnormal_sebaceous_gland1.14336819
49MP0002735_abnormal_chemical_nociception1.14170881
50MP0001727_abnormal_embryo_implantation1.09281144
51MP0005394_taste/olfaction_phenotype1.08869904
52MP0005499_abnormal_olfactory_system1.08869904
53MP0000490_abnormal_crypts_of1.08759905
54MP0005389_reproductive_system_phenotype1.08646016
55MP0003119_abnormal_digestive_system1.07253461
56MP0003984_embryonic_growth_retardation1.06698489
57MP0002019_abnormal_tumor_incidence1.04780328
58MP0002876_abnormal_thyroid_physiology1.03823322
59MP0004147_increased_porphyrin_level1.02296717
60MP0003221_abnormal_cardiomyocyte_apopto1.02237682
61MP0002088_abnormal_embryonic_growth/wei1.02047018
62MP0001286_abnormal_eye_development1.01975213
63MP0002751_abnormal_autonomic_nervous1.01382139
64MP0009672_abnormal_birth_weight1.01345937
65MP0002234_abnormal_pharynx_morphology1.01341347
66MP0005253_abnormal_eye_physiology1.00926260
67MP0010307_abnormal_tumor_latency1.00727268
68MP0003567_abnormal_fetal_cardiomyocyte0.98898986
69MP0002233_abnormal_nose_morphology0.96633661
70MP0002210_abnormal_sex_determination0.96145645
71MP0003890_abnormal_embryonic-extraembry0.95287697
72MP0005266_abnormal_metabolism0.94169027
73MP0002090_abnormal_vision0.91939859
74MP0002111_abnormal_tail_morphology0.91616403
75MP0001968_abnormal_touch/_nociception0.90672842
76MP0003136_yellow_coat_color0.90410524
77MP0002085_abnormal_embryonic_tissue0.89770462
78MP0002837_dystrophic_cardiac_calcinosis0.87677566
79MP0002697_abnormal_eye_size0.87557869
80MP0004215_abnormal_myocardial_fiber0.86750157
81MP0002132_abnormal_respiratory_system0.84593683
82MP0002102_abnormal_ear_morphology0.83859943
83MP0001919_abnormal_reproductive_system0.83623759
84MP0001986_abnormal_taste_sensitivity0.82951203
85MP0001188_hyperpigmentation0.82601915
86MP0003122_maternal_imprinting0.81147351
87MP0005084_abnormal_gallbladder_morpholo0.79569643
88MP0005384_cellular_phenotype0.78891887
89MP0004808_abnormal_hematopoietic_stem0.77553494
90MP0003195_calcinosis0.77000834
91MP0005391_vision/eye_phenotype0.76062431
92MP0001145_abnormal_male_reproductive0.75366488
93MP0000015_abnormal_ear_pigmentation0.75362880
94MP0001764_abnormal_homeostasis0.74339406
95MP0001853_heart_inflammation0.74138892
96MP0003755_abnormal_palate_morphology0.73379426
97MP0005408_hypopigmentation0.72596985
98MP0009703_decreased_birth_body0.72309924
99MP0003938_abnormal_ear_development0.71779720
100MP0002084_abnormal_developmental_patter0.71434154
101MP0006054_spinal_hemorrhage0.71157657
102MP0001299_abnormal_eye_distance/0.70895228
103MP0004197_abnormal_fetal_growth/weight/0.70870742
104MP0001177_atelectasis0.69688624
105MP0002095_abnormal_skin_pigmentation0.69238142
106MP0010030_abnormal_orbit_morphology0.68806123
107MP0001485_abnormal_pinna_reflex0.68245155
108MP0000049_abnormal_middle_ear0.67573984
109MP0000579_abnormal_nail_morphology0.67012619
110MP0001984_abnormal_olfaction0.66598870
111MP0005187_abnormal_penis_morphology0.66173678
112MP0002086_abnormal_extraembryonic_tissu0.65847571
113MP0002332_abnormal_exercise_endurance0.64773393
114MP0004133_heterotaxia0.64669959
115MP0003698_abnormal_male_reproductive0.64082405
116MP0008789_abnormal_olfactory_epithelium0.63870240
117MP0005367_renal/urinary_system_phenotyp0.63839161
118MP0000516_abnormal_urinary_system0.63839161
119MP0003941_abnormal_skin_development0.62410221
120MP0000749_muscle_degeneration0.62191915
121MP0005075_abnormal_melanosome_morpholog0.61828582
122MP0005551_abnormal_eye_electrophysiolog0.61782678
123MP0001929_abnormal_gametogenesis0.61635032
124MP0002398_abnormal_bone_marrow0.61528805
125MP0000631_abnormal_neuroendocrine_gland0.60990100
126MP0004142_abnormal_muscle_tone0.60104634
127MP0000653_abnormal_sex_gland0.59374622
128MP0000689_abnormal_spleen_morphology0.59297419
129MP0005621_abnormal_cell_physiology0.58690402
130MP0002722_abnormal_immune_system0.57614889
131MP0002148_abnormal_hypersensitivity_rea0.56331768
132MP0003656_abnormal_erythrocyte_physiolo0.56276805
133MP0005395_other_phenotype0.56223644
134MP0005376_homeostasis/metabolism_phenot0.53931632
135MP0005397_hematopoietic_system_phenotyp0.53688668
136MP0001545_abnormal_hematopoietic_system0.53688668
137MP0001119_abnormal_female_reproductive0.53308426

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.37732136
2Acute necrotizing encephalopathy (HP:0006965)4.80888466
3Increased serum pyruvate (HP:0003542)4.72454269
4Abnormality of glycolysis (HP:0004366)4.72454269
5Abnormal mitochondria in muscle tissue (HP:0008316)4.37428051
6Mitochondrial inheritance (HP:0001427)4.14503893
7Increased CSF lactate (HP:0002490)3.94499017
8Progressive macrocephaly (HP:0004481)3.94003506
9Cerebral hypomyelination (HP:0006808)3.82618654
10Breast hypoplasia (HP:0003187)3.70017190
11Acute encephalopathy (HP:0006846)3.65633996
12Hepatocellular necrosis (HP:0001404)3.58095202
13Abnormality of the labia minora (HP:0012880)3.44963187
14Increased hepatocellular lipid droplets (HP:0006565)3.27306059
15Abnormality of cells of the erythroid lineage (HP:0012130)3.20817971
16Increased serum lactate (HP:0002151)3.19559528
17Carpal bone hypoplasia (HP:0001498)3.02389132
18Oral leukoplakia (HP:0002745)3.01001039
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00908977
203-Methylglutaconic aciduria (HP:0003535)2.98233849
21Hepatic necrosis (HP:0002605)2.97976871
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97539033
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97539033
24Irregular epiphyses (HP:0010582)2.96917826
25Abnormal number of erythroid precursors (HP:0012131)2.96118539
26Rough bone trabeculation (HP:0100670)2.95496726
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.92594781
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.83280915
29Exercise intolerance (HP:0003546)2.78778570
30Methylmalonic aciduria (HP:0012120)2.76815378
31Lipid accumulation in hepatocytes (HP:0006561)2.75061951
32Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71502499
33Volvulus (HP:0002580)2.66647003
34Patellar aplasia (HP:0006443)2.65942641
35Degeneration of anterior horn cells (HP:0002398)2.65261792
36Abnormality of the anterior horn cell (HP:0006802)2.65261792
37Type I transferrin isoform profile (HP:0003642)2.59184393
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52474598
39Abnormality of alanine metabolism (HP:0010916)2.52474598
40Hyperalaninemia (HP:0003348)2.52474598
41Respiratory failure (HP:0002878)2.51925031
42Aplasia/Hypoplasia of the patella (HP:0006498)2.51507015
43Postnatal microcephaly (HP:0005484)2.51215745
44Methylmalonic acidemia (HP:0002912)2.49691032
45Macrocytic anemia (HP:0001972)2.48651127
46Reticulocytopenia (HP:0001896)2.48343837
47Lactic acidosis (HP:0003128)2.47937153
48Aplastic anemia (HP:0001915)2.44693490
49Cerebral edema (HP:0002181)2.44606320
50Abnormality of methionine metabolism (HP:0010901)2.44262181
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44045319
52Respiratory difficulties (HP:0002880)2.42785864
53Agnosia (HP:0010524)2.41467743
54Microvesicular hepatic steatosis (HP:0001414)2.38979204
55Abnormality of the preputium (HP:0100587)2.38573951
56Renal Fanconi syndrome (HP:0001994)2.36720104
57Leukodystrophy (HP:0002415)2.32959618
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.30448943
59Absent epiphyses (HP:0010577)2.30448943
60CNS hypomyelination (HP:0003429)2.28296066
61Abnormal trabecular bone morphology (HP:0100671)2.26995179
62Exertional dyspnea (HP:0002875)2.24747144
63Hyperglycinemia (HP:0002154)2.22685204
64Abnormality of the duodenum (HP:0002246)2.22375425
65Abnormality of serum amino acid levels (HP:0003112)2.19943530
66Cortical dysplasia (HP:0002539)2.15931279
67CNS demyelination (HP:0007305)2.12409228
68Stenosis of the external auditory canal (HP:0000402)2.11497827
69Glossoptosis (HP:0000162)2.11433852
70Microretrognathia (HP:0000308)2.11075133
71Emotional lability (HP:0000712)2.10880837
72Meckel diverticulum (HP:0002245)2.10709095
73Nephroblastoma (Wilms tumor) (HP:0002667)2.09627358
74Abnormal hair whorl (HP:0010721)2.09087332
75Secondary amenorrhea (HP:0000869)2.08901780
76Premature graying of hair (HP:0002216)2.08231822
77Cellular immunodeficiency (HP:0005374)2.07057990
78Abnormal lung lobation (HP:0002101)2.06781070
79Absent radius (HP:0003974)2.06573661
80Delusions (HP:0000746)2.06488115
81Chromsome breakage (HP:0040012)2.04691610
82Pallor (HP:0000980)2.04459806
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03798824
84Embryonal renal neoplasm (HP:0011794)2.03687405
85Trismus (HP:0000211)2.01786777
86Abnormal protein glycosylation (HP:0012346)2.00668303
87Abnormal glycosylation (HP:0012345)2.00668303
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00668303
89Abnormal protein N-linked glycosylation (HP:0012347)2.00668303
90Selective tooth agenesis (HP:0001592)1.99799907
91Sloping forehead (HP:0000340)1.99249171
92Abnormality of the ileum (HP:0001549)1.98744115
93Bone marrow hypocellularity (HP:0005528)1.97842630
94Poor head control (HP:0002421)1.97520270
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97010054
96Optic disc pallor (HP:0000543)1.95228606
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94769416
98Increased intramyocellular lipid droplets (HP:0012240)1.94662039
99Autoamputation (HP:0001218)1.94419083
100Colon cancer (HP:0003003)1.92697170
101Megaloblastic anemia (HP:0001889)1.92213818
102Ependymoma (HP:0002888)1.91914851
103Horseshoe kidney (HP:0000085)1.91399454
104Cleft eyelid (HP:0000625)1.91125980
105Absent thumb (HP:0009777)1.91111388
106Abnormality of chromosome stability (HP:0003220)1.90592544
107Hypoplastic pelvis (HP:0008839)1.90538579
108Neoplasm of the adrenal gland (HP:0100631)1.89472433
109Aplasia involving forearm bones (HP:0009822)1.88916942
110Absent forearm bone (HP:0003953)1.88916942
111Premature ovarian failure (HP:0008209)1.87669467
112Lethargy (HP:0001254)1.87614750
113Reduced antithrombin III activity (HP:0001976)1.85910691
114Duodenal stenosis (HP:0100867)1.85662484
115Small intestinal stenosis (HP:0012848)1.85662484
116Amniotic constriction ring (HP:0009775)1.85180174
117Abnormality of placental membranes (HP:0011409)1.85180174
118Supernumerary spleens (HP:0009799)1.84828858
119Multiple enchondromatosis (HP:0005701)1.84499948
120Sparse eyelashes (HP:0000653)1.83969093
121Parakeratosis (HP:0001036)1.82476489
122Triphalangeal thumb (HP:0001199)1.81503654
123Abnormality of the carotid arteries (HP:0005344)1.79060343
124Type 2 muscle fiber atrophy (HP:0003554)1.79025694
125Unsteady gait (HP:0002317)1.77564149
126Increased nuchal translucency (HP:0010880)1.77529648
127Pancreatic islet-cell hyperplasia (HP:0004510)1.75247868
128Myelodysplasia (HP:0002863)1.75101678
129Neuroendocrine neoplasm (HP:0100634)1.73858604
130Tongue fasciculations (HP:0001308)1.73604933
131Congenital, generalized hypertrichosis (HP:0004540)1.73049617
132Adrenal hypoplasia (HP:0000835)1.71919683
133Pancytopenia (HP:0001876)1.71084903
134Medulloblastoma (HP:0002885)1.70018108
135Neoplasm of the colon (HP:0100273)1.66999787
136Rhabdomyosarcoma (HP:0002859)1.66755924
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64159303
138Abnormality of glycine metabolism (HP:0010895)1.62618370
139Abnormality of serine family amino acid metabolism (HP:0010894)1.62618370
140Pancreatic fibrosis (HP:0100732)1.61976965
141Intestinal atresia (HP:0011100)1.61880671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.06003077
2EIF2AK13.91004745
3WEE13.82725818
4STK163.39396320
5TSSK63.14038166
6EIF2AK32.85033162
7VRK22.71835147
8TRIM282.68875049
9SRPK12.45691017
10NME22.44419425
11PBK2.41474791
12CDC72.35159360
13BRSK22.25691965
14PLK42.11001530
15NEK11.98564108
16NME11.98429790
17VRK11.98283814
18PLK31.97869442
19MAP3K121.90840107
20CCNB11.90304056
21MKNK11.85632241
22TESK21.79205888
23NUAK11.72713312
24ACVR1B1.66644824
25MST41.60127036
26WNK31.55165593
27PIM21.54051845
28BRSK11.50201268
29PLK11.46163361
30CASK1.45594132
31PLK21.38976844
32TTK1.38033776
33ARAF1.37398951
34BCR1.36648560
35LIMK11.33322064
36BRAF1.23755863
37TAF11.22780201
38ZAK1.20695468
39AURKA1.16214502
40MKNK21.15326464
41AURKB1.08652743
42MAP3K41.06698923
43EIF2AK21.06373212
44TLK11.05911480
45MAP4K21.04874459
46TNIK1.04606112
47TESK11.03248963
48AKT31.01421247
49CSNK1G11.00390865
50CSNK1G20.95219224
51NEK20.94993859
52EPHA20.94953999
53ATR0.87351347
54PASK0.85748071
55CHEK20.85726801
56ERBB30.83472857
57TGFBR10.82164422
58CSNK1A1L0.81506269
59PNCK0.80054792
60DYRK20.79727368
61RPS6KB20.78823042
62ERBB40.77116822
63DYRK30.73141620
64CDK80.72646298
65CDK190.71228494
66ADRBK20.69614215
67CSNK2A10.69524839
68STK390.68610111
69SIK30.68166129
70CSNK2A20.67792503
71CDK70.66528711
72RPS6KA40.65502309
73BMPR20.62504978
74DAPK10.60139602
75CHEK10.59481353
76ABL20.59387764
77PDK40.57654997
78PDK30.57654997
79PAK10.57178432
80STK30.57089090
81ALK0.55278463
82PAK40.50859144
83BCKDK0.49282203
84YES10.49123524
85STK40.48151018
86RPS6KA50.47476187
87FGFR10.46752315
88CDK140.46685746
89CDK180.46145724
90STK100.45920313
91MAP3K80.44996175
92TIE10.44589433
93PRKCI0.43959098
94MAP2K70.42662566
95CSNK1E0.41210229
96STK240.38966823
97CSNK1G30.38906216
98CDK150.38717303
99PIM10.38318236
100MYLK0.38313508
101CLK10.36223016
102PDK20.36052051
103IRAK40.35643747
104CDK11A0.34932265
105GRK50.34731594
106CDK10.33757235
107CDK20.33547152
108WNK40.33250248
109BMPR1B0.33135349
110FRK0.33019391
111SCYL20.32818677
112ATM0.32683956
113STK38L0.32467337
114LATS10.31144483
115GRK10.31117768
116TXK0.31016687
117MINK10.29261633
118MAPK130.28991674
119MAP3K110.28746821
120PRKCG0.27992843
121CDK30.27437692
122NEK60.26533379
123PRKDC0.26531821
124KDR0.24380436
125OXSR10.22888176
126GRK70.22687826
127TAOK20.22582046

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.63230427
2DNA replication_Homo sapiens_hsa030303.94758788
3RNA polymerase_Homo sapiens_hsa030203.80043995
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66343003
5Ribosome_Homo sapiens_hsa030103.50002777
6Mismatch repair_Homo sapiens_hsa034303.37234494
7Spliceosome_Homo sapiens_hsa030402.81273033
8Nucleotide excision repair_Homo sapiens_hsa034202.71031728
9RNA transport_Homo sapiens_hsa030132.71010257
10Oxidative phosphorylation_Homo sapiens_hsa001902.68803043
11Pyrimidine metabolism_Homo sapiens_hsa002402.52587079
12Homologous recombination_Homo sapiens_hsa034402.50973114
13Parkinsons disease_Homo sapiens_hsa050122.37999211
14Base excision repair_Homo sapiens_hsa034102.31786815
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21448986
16Cell cycle_Homo sapiens_hsa041102.01975729
17Basal transcription factors_Homo sapiens_hsa030221.94387940
18Huntingtons disease_Homo sapiens_hsa050161.91064475
19Propanoate metabolism_Homo sapiens_hsa006401.89298500
20Protein export_Homo sapiens_hsa030601.80620213
21Non-homologous end-joining_Homo sapiens_hsa034501.69516376
22One carbon pool by folate_Homo sapiens_hsa006701.69470471
23RNA degradation_Homo sapiens_hsa030181.56152953
24Fanconi anemia pathway_Homo sapiens_hsa034601.52255159
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50007819
26Purine metabolism_Homo sapiens_hsa002301.47957077
27Alzheimers disease_Homo sapiens_hsa050101.45190529
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36219041
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34068209
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32556458
31* Epstein-Barr virus infection_Homo sapiens_hsa051691.24306965
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19865047
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14067295
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13674041
35Collecting duct acid secretion_Homo sapiens_hsa049661.13550228
36p53 signaling pathway_Homo sapiens_hsa041151.10138284
37mRNA surveillance pathway_Homo sapiens_hsa030151.08206065
38Vitamin B6 metabolism_Homo sapiens_hsa007501.03817517
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96544811
40Selenocompound metabolism_Homo sapiens_hsa004500.96430885
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88093006
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.87237690
43Pentose phosphate pathway_Homo sapiens_hsa000300.84566462
44Oocyte meiosis_Homo sapiens_hsa041140.82610048
45Vibrio cholerae infection_Homo sapiens_hsa051100.79588774
46Glutathione metabolism_Homo sapiens_hsa004800.77473230
47Systemic lupus erythematosus_Homo sapiens_hsa053220.77075869
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.75539563
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70342682
50Legionellosis_Homo sapiens_hsa051340.66592927
51Biosynthesis of amino acids_Homo sapiens_hsa012300.64817197
52Butanoate metabolism_Homo sapiens_hsa006500.64325272
53Sulfur metabolism_Homo sapiens_hsa009200.62642400
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62289181
55Carbon metabolism_Homo sapiens_hsa012000.62135079
56Peroxisome_Homo sapiens_hsa041460.60972764
57Fatty acid metabolism_Homo sapiens_hsa012120.58643040
58Phagosome_Homo sapiens_hsa041450.58601846
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56684290
60Folate biosynthesis_Homo sapiens_hsa007900.55062933
61Regulation of autophagy_Homo sapiens_hsa041400.54886008
62Rheumatoid arthritis_Homo sapiens_hsa053230.53942592
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52072138
64Fructose and mannose metabolism_Homo sapiens_hsa000510.51450303
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51370858
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51092089
67Metabolic pathways_Homo sapiens_hsa011000.50307422
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50244774
69Viral carcinogenesis_Homo sapiens_hsa052030.49154827
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47569296
71Arginine and proline metabolism_Homo sapiens_hsa003300.45403795
72Phototransduction_Homo sapiens_hsa047440.44884618
73Allograft rejection_Homo sapiens_hsa053300.44691127
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44250533
75Cardiac muscle contraction_Homo sapiens_hsa042600.43899551
76Shigellosis_Homo sapiens_hsa051310.42509891
77Antigen processing and presentation_Homo sapiens_hsa046120.40103318
78Arachidonic acid metabolism_Homo sapiens_hsa005900.39903353
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39708147
80Fatty acid degradation_Homo sapiens_hsa000710.39518843
81beta-Alanine metabolism_Homo sapiens_hsa004100.39503282
82Asthma_Homo sapiens_hsa053100.39448601
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.39009205
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38929682
85Type I diabetes mellitus_Homo sapiens_hsa049400.38005566
86Pyruvate metabolism_Homo sapiens_hsa006200.37714317
87Graft-versus-host disease_Homo sapiens_hsa053320.37303242
88Herpes simplex infection_Homo sapiens_hsa051680.36783445
89Autoimmune thyroid disease_Homo sapiens_hsa053200.34619611
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33988111
91TGF-beta signaling pathway_Homo sapiens_hsa043500.33621366
92Tryptophan metabolism_Homo sapiens_hsa003800.33519980
93Fatty acid elongation_Homo sapiens_hsa000620.32582285
94Synaptic vesicle cycle_Homo sapiens_hsa047210.31887411
95Alcoholism_Homo sapiens_hsa050340.30366883
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29842304
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28786291
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27383902
99Hippo signaling pathway_Homo sapiens_hsa043900.24531038
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24339425
101N-Glycan biosynthesis_Homo sapiens_hsa005100.23167583
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19565738
103Steroid biosynthesis_Homo sapiens_hsa001000.19197450
104HTLV-I infection_Homo sapiens_hsa051660.18955592
105Caffeine metabolism_Homo sapiens_hsa002320.18791855
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18752229
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17066214
108Retinol metabolism_Homo sapiens_hsa008300.15317367
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.14783151
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14015754
111Apoptosis_Homo sapiens_hsa042100.13447777
112Nitrogen metabolism_Homo sapiens_hsa009100.13241827
113Basal cell carcinoma_Homo sapiens_hsa052170.12310009
114Thyroid cancer_Homo sapiens_hsa052160.11546993
115Hedgehog signaling pathway_Homo sapiens_hsa043400.11219850
116Wnt signaling pathway_Homo sapiens_hsa043100.10852578
117Vitamin digestion and absorption_Homo sapiens_hsa049770.10799566
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09801790
119Chemical carcinogenesis_Homo sapiens_hsa052040.08166987
120Measles_Homo sapiens_hsa051620.07853655
121Tight junction_Homo sapiens_hsa045300.07635066
122Renin-angiotensin system_Homo sapiens_hsa046140.06922672
123Sulfur relay system_Homo sapiens_hsa041220.06915724
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05092655
125HIF-1 signaling pathway_Homo sapiens_hsa040660.04853882
126Hematopoietic cell lineage_Homo sapiens_hsa046400.04314431
127Galactose metabolism_Homo sapiens_hsa000520.03455966
128Ether lipid metabolism_Homo sapiens_hsa005650.03370730
129Tyrosine metabolism_Homo sapiens_hsa003500.02954367
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02901174
131Phenylalanine metabolism_Homo sapiens_hsa003600.02539738
132Sphingolipid metabolism_Homo sapiens_hsa006000.02531922

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