PSMD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.80499374
2nucleobase biosynthetic process (GO:0046112)4.74494077
3establishment of integrated proviral latency (GO:0075713)4.65351270
4* proteasome assembly (GO:0043248)4.55503379
5ribosome assembly (GO:0042255)4.54717126
6formation of translation preinitiation complex (GO:0001731)4.43325468
7* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.34058881
8ribosome biogenesis (GO:0042254)4.33778737
9mitotic metaphase plate congression (GO:0007080)4.24442009
10* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.18818877
11maturation of SSU-rRNA (GO:0030490)4.15759687
12* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.13908582
13* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.13845479
14rRNA modification (GO:0000154)4.06387716
15DNA deamination (GO:0045006)4.02631358
16DNA replication checkpoint (GO:0000076)3.99492651
17DNA replication initiation (GO:0006270)3.94659318
18DNA strand elongation involved in DNA replication (GO:0006271)3.94441681
19ribonucleoprotein complex biogenesis (GO:0022613)3.92628924
20* negative regulation of ligase activity (GO:0051352)3.91347378
21* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91347378
22* regulation of cellular amino acid metabolic process (GO:0006521)3.89614941
23termination of RNA polymerase III transcription (GO:0006386)3.87334371
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.87334371
25ribosomal large subunit biogenesis (GO:0042273)3.85122752
26mitotic sister chromatid segregation (GO:0000070)3.84679279
27DNA strand elongation (GO:0022616)3.75268352
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73916198
29* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72667598
30folic acid metabolic process (GO:0046655)3.72521449
31* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72505739
32non-recombinational repair (GO:0000726)3.69700644
33double-strand break repair via nonhomologous end joining (GO:0006303)3.69700644
34telomere maintenance via semi-conservative replication (GO:0032201)3.67642370
35* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.67473835
36* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.67473835
37* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.67473835
38spliceosomal snRNP assembly (GO:0000387)3.66397512
39* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65549091
40* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65549091
41establishment of viral latency (GO:0019043)3.65396121
42* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63349196
43* signal transduction involved in DNA damage checkpoint (GO:0072422)3.63349196
44histone exchange (GO:0043486)3.62486030
45cullin deneddylation (GO:0010388)3.61628927
46* signal transduction involved in cell cycle checkpoint (GO:0072395)3.59484860
47rRNA processing (GO:0006364)3.59068766
48spindle checkpoint (GO:0031577)3.57798441
49* positive regulation of ligase activity (GO:0051351)3.57604710
50sister chromatid segregation (GO:0000819)3.56880509
51pseudouridine synthesis (GO:0001522)3.52709642
52folic acid-containing compound biosynthetic process (GO:0009396)3.51335563
53IMP metabolic process (GO:0046040)3.50207012
547-methylguanosine mRNA capping (GO:0006370)3.48973802
55rRNA metabolic process (GO:0016072)3.47306161
56protein deneddylation (GO:0000338)3.46896290
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44839182
58metaphase plate congression (GO:0051310)3.43651066
597-methylguanosine RNA capping (GO:0009452)3.42951779
60RNA capping (GO:0036260)3.42951779
61mitotic spindle checkpoint (GO:0071174)3.41710784
62DNA double-strand break processing (GO:0000729)3.41540526
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38045108
64termination of RNA polymerase I transcription (GO:0006363)3.36215441
65CENP-A containing nucleosome assembly (GO:0034080)3.36036120
66positive regulation of chromosome segregation (GO:0051984)3.36027497
67L-methionine salvage (GO:0071267)3.35609133
68L-methionine biosynthetic process (GO:0071265)3.35609133
69amino acid salvage (GO:0043102)3.35609133
70DNA ligation (GO:0006266)3.35139800
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34973144
72* G1/S transition of mitotic cell cycle (GO:0000082)3.32988806
73* cell cycle G1/S phase transition (GO:0044843)3.32988806
74maturation of 5.8S rRNA (GO:0000460)3.32694298
75mitotic nuclear envelope disassembly (GO:0007077)3.31276564
76IMP biosynthetic process (GO:0006188)3.30813022
77telomere maintenance via recombination (GO:0000722)3.30792105
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.29404977
79DNA catabolic process, exonucleolytic (GO:0000738)3.27896703
80* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27839356
81chaperone-mediated protein transport (GO:0072321)3.26674723
82* regulation of ubiquitin-protein transferase activity (GO:0051438)3.26385454
83chromatin remodeling at centromere (GO:0031055)3.26339384
84transcription from RNA polymerase I promoter (GO:0006360)3.26237247
85* negative regulation of protein ubiquitination (GO:0031397)3.22896336
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22453878
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22453878
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22453878
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.22453878
90negative regulation of sister chromatid segregation (GO:0033046)3.22453878
91regulation of chromosome segregation (GO:0051983)3.22295538
92negative regulation of chromosome segregation (GO:0051985)3.20961710
93ribosomal small subunit assembly (GO:0000028)3.19241694
94transcription-coupled nucleotide-excision repair (GO:0006283)3.18485636
95tRNA aminoacylation for protein translation (GO:0006418)3.16805597
96cellular component biogenesis (GO:0044085)3.16738533
97* regulation of cellular amine metabolic process (GO:0033238)3.16210635
98protein localization to chromosome, centromeric region (GO:0071459)3.16188917
99* regulation of ligase activity (GO:0051340)3.15951262
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14671873
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14671873
102DNA damage response, detection of DNA damage (GO:0042769)3.14486442
103amino acid activation (GO:0043038)3.13627018
104tRNA aminoacylation (GO:0043039)3.13627018
105ribosomal small subunit biogenesis (GO:0042274)3.13396176
106nuclear pore complex assembly (GO:0051292)3.12591641
107rRNA methylation (GO:0031167)3.11803600
108replication fork processing (GO:0031297)3.09604200
109regulation of spindle organization (GO:0090224)3.09363000
110telomere maintenance via telomere lengthening (GO:0010833)3.08947003
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.07482008
112mitotic spindle assembly checkpoint (GO:0007094)3.06940811
113mitotic recombination (GO:0006312)3.06715495
114protein K6-linked ubiquitination (GO:0085020)3.06044640
115DNA unwinding involved in DNA replication (GO:0006268)3.05998025
116protein localization to kinetochore (GO:0034501)3.05521216
117* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04328850
118spindle assembly checkpoint (GO:0071173)3.03507747
119* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.03447245
120regulation of sister chromatid segregation (GO:0033045)3.02818033
121regulation of mitotic sister chromatid separation (GO:0010965)3.02818033
122regulation of mitotic sister chromatid segregation (GO:0033047)3.02818033
123DNA replication-dependent nucleosome assembly (GO:0006335)3.02621145
124DNA replication-dependent nucleosome organization (GO:0034723)3.02621145
125translational initiation (GO:0006413)3.02029150
126* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01676609
127* positive regulation of cell cycle arrest (GO:0071158)3.01483988
128glycine metabolic process (GO:0006544)3.01182355
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00222421
130membrane disassembly (GO:0030397)3.00047038
131nuclear envelope disassembly (GO:0051081)3.00047038
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.99143519
133DNA replication-independent nucleosome organization (GO:0034724)2.95731062
134DNA replication-independent nucleosome assembly (GO:0006336)2.95731062
135methionine biosynthetic process (GO:0009086)2.95131323
136translation (GO:0006412)2.92784686
137spliceosomal complex assembly (GO:0000245)2.92426436
138establishment of chromosome localization (GO:0051303)2.92365610
139transcription initiation from RNA polymerase I promoter (GO:0006361)2.91945381
140regulation of mitochondrial translation (GO:0070129)2.91661971
141regulation of translation in response to stress (GO:0043555)2.90690492
142regulation of double-strand break repair via homologous recombination (GO:0010569)2.88991501
143kinetochore assembly (GO:0051382)2.88813093
144viral mRNA export from host cell nucleus (GO:0046784)2.86013095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01413732
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47824889
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12184211
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.65926544
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63535864
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.61251990
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61224776
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.40851255
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34021594
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.31272085
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19546826
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07681291
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00112080
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97624751
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95029575
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72170327
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.63525652
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63078153
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49090150
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45724814
21* VDR_23849224_ChIP-Seq_CD4+_Human2.43961894
22XRN2_22483619_ChIP-Seq_HELA_Human2.32922067
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31333361
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30452019
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27669197
26DCP1A_22483619_ChIP-Seq_HELA_Human2.26601682
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14920551
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14112175
29AR_21909140_ChIP-Seq_LNCAP_Human2.10532730
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04548662
31FOXP3_21729870_ChIP-Seq_TREG_Human2.04222089
32* GABP_19822575_ChIP-Seq_HepG2_Human2.01661599
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94756578
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.91622624
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91490436
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88045060
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87942834
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87881865
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.86569751
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84228268
41ELK1_19687146_ChIP-ChIP_HELA_Human1.80295521
42TTF2_22483619_ChIP-Seq_HELA_Human1.79258694
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.74916952
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67770847
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65084544
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64007255
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63765316
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.51679223
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48857886
50KDM5A_27292631_Chip-Seq_BREAST_Human1.46695444
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46491308
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45333294
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43682846
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41905566
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41197389
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36716236
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35406216
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29696090
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25433277
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24348876
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.23511568
62* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20027735
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19090106
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.18472168
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17724614
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16440365
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16087962
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15699073
69CIITA_25753668_ChIP-Seq_RAJI_Human1.15563221
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14109959
71VDR_22108803_ChIP-Seq_LS180_Human1.13072898
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11939163
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11885834
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10957935
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10957935
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10957935
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10115782
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.09927842
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09670328
80TFEB_21752829_ChIP-Seq_HELA_Human1.09602273
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08647733
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06345860
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06048236
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05242498
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04318898
86EWS_26573619_Chip-Seq_HEK293_Human1.04010525
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03644823
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01184560
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00764538
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00577232
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99887996
92MYC_18940864_ChIP-ChIP_HL60_Human0.98125700
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96992195
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95769737
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95425478
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93681349
97ZNF274_21170338_ChIP-Seq_K562_Hela0.92175679
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92090304
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.91469529
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.91046887
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.88898519
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88412230
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88172347
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87031145
105FUS_26573619_Chip-Seq_HEK293_Human0.85503281
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84036625
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83813703
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80629677
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.79514578
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79329364
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75785087
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.74243069
113NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73637179
114* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72946567
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71182123
116ELF5_23300383_ChIP-Seq_T47D_Human0.69368595
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67105120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81405594
2MP0004957_abnormal_blastocyst_morpholog4.72633599
3MP0003111_abnormal_nucleus_morphology4.29666873
4MP0010094_abnormal_chromosome_stability4.11239132
5MP0003806_abnormal_nucleotide_metabolis3.86659709
6MP0003077_abnormal_cell_cycle3.67459945
7MP0008057_abnormal_DNA_replication3.64569684
8MP0008058_abnormal_DNA_repair3.45406540
9MP0003718_maternal_effect3.09639946
10MP0008932_abnormal_embryonic_tissue2.97990680
11MP0000372_irregular_coat_pigmentation2.86322225
12MP0008007_abnormal_cellular_replicative2.43028109
13MP0003786_premature_aging2.29085106
14MP0001730_embryonic_growth_arrest2.18378937
15MP0003186_abnormal_redox_activity2.15571530
16MP0002102_abnormal_ear_morphology1.95602612
17MP0002938_white_spotting1.91188474
18MP0008260_abnormal_autophagy1.90543149
19MP0000350_abnormal_cell_proliferation1.88095171
20MP0003123_paternal_imprinting1.82762456
21MP0008877_abnormal_DNA_methylation1.72535449
22MP0005171_absent_coat_pigmentation1.72400407
23MP0001672_abnormal_embryogenesis/_devel1.61160220
24MP0005380_embryogenesis_phenotype1.61160220
25MP0001697_abnormal_embryo_size1.47282865
26MP0003941_abnormal_skin_development1.44586950
27MP0009697_abnormal_copulation1.42713465
28MP0006292_abnormal_olfactory_placode1.42495653
29MP0002080_prenatal_lethality1.41413935
30MP0003984_embryonic_growth_retardation1.41323167
31MP0002088_abnormal_embryonic_growth/wei1.38721529
32MP0002254_reproductive_system_inflammat1.37462322
33MP0001529_abnormal_vocalization1.36556863
34MP0006035_abnormal_mitochondrial_morpho1.35741317
35MP0006036_abnormal_mitochondrial_physio1.31100151
36MP0003567_abnormal_fetal_cardiomyocyte1.31072720
37MP0009840_abnormal_foam_cell1.29531190
38MP0010030_abnormal_orbit_morphology1.27396430
39MP0009333_abnormal_splenocyte_physiolog1.23165280
40MP0000647_abnormal_sebaceous_gland1.22716749
41MP0002085_abnormal_embryonic_tissue1.22518921
42MP0002396_abnormal_hematopoietic_system1.22334097
43MP0000313_abnormal_cell_death1.19436448
44MP0000358_abnormal_cell_content/1.15783713
45MP0005395_other_phenotype1.12426066
46MP0003315_abnormal_perineum_morphology1.11150534
47MP0000490_abnormal_crypts_of1.10472809
48MP0001542_abnormal_bone_strength1.10319126
49MP0010352_gastrointestinal_tract_polyps1.10111438
50MP0002210_abnormal_sex_determination1.10092431
51MP0002019_abnormal_tumor_incidence1.08099373
52MP0004133_heterotaxia1.07706329
53MP0003221_abnormal_cardiomyocyte_apopto1.07674998
54MP0001293_anophthalmia1.07564581
55MP0002160_abnormal_reproductive_system1.07288600
56MP0002751_abnormal_autonomic_nervous1.07006018
57MP0003890_abnormal_embryonic-extraembry1.06891950
58MP0009379_abnormal_foot_pigmentation1.04986290
59MP0006072_abnormal_retinal_apoptosis1.04402151
60MP0002090_abnormal_vision1.04174505
61MP0002084_abnormal_developmental_patter1.03438619
62MP0002086_abnormal_extraembryonic_tissu1.00568745
63MP0005389_reproductive_system_phenotype0.99128170
64MP0000750_abnormal_muscle_regeneration0.98199401
65MP0002132_abnormal_respiratory_system0.97977583
66MP0002139_abnormal_hepatobiliary_system0.97134488
67MP0004197_abnormal_fetal_growth/weight/0.96684016
68MP0005451_abnormal_body_composition0.95801463
69MP0003950_abnormal_plasma_membrane0.94874686
70MP0001764_abnormal_homeostasis0.94781571
71MP0001145_abnormal_male_reproductive0.94012737
72MP0000015_abnormal_ear_pigmentation0.93240160
73MP0000749_muscle_degeneration0.92016482
74MP0005085_abnormal_gallbladder_physiolo0.90440351
75MP0005266_abnormal_metabolism0.89678615
76MP0009053_abnormal_anal_canal0.88000274
77MP0002095_abnormal_skin_pigmentation0.86621062
78MP0005332_abnormal_amino_acid0.85338141
79MP0010307_abnormal_tumor_latency0.83633090
80MP0003937_abnormal_limbs/digits/tail_de0.83102538
81MP0005408_hypopigmentation0.82680194
82MP0002111_abnormal_tail_morphology0.82567656
83MP0003119_abnormal_digestive_system0.81312138
84MP0005253_abnormal_eye_physiology0.81062723
85MP0003136_yellow_coat_color0.80767033
86MP0005075_abnormal_melanosome_morpholog0.80444228
87MP0000653_abnormal_sex_gland0.79901253
88MP0001119_abnormal_female_reproductive0.78923998
89MP0005084_abnormal_gallbladder_morpholo0.78187312
90MP0009672_abnormal_birth_weight0.75690139
91MP0001919_abnormal_reproductive_system0.75477346
92MP0000516_abnormal_urinary_system0.75428317
93MP0005367_renal/urinary_system_phenotyp0.75428317
94MP0001727_abnormal_embryo_implantation0.75326137
95MP0002736_abnormal_nociception_after0.74978626
96MP0002233_abnormal_nose_morphology0.74391326
97MP0004147_increased_porphyrin_level0.74377623
98MP0003646_muscle_fatigue0.73531307
99MP0004215_abnormal_myocardial_fiber0.73217554
100MP0001929_abnormal_gametogenesis0.72993139
101MP0009703_decreased_birth_body0.72136074
102MP0005365_abnormal_bile_salt0.70891780
103MP0005384_cellular_phenotype0.70393359
104MP0001324_abnormal_eye_pigmentation0.70177105
105MP0002269_muscular_atrophy0.69838365
106MP0002697_abnormal_eye_size0.69615061
107MP0001188_hyperpigmentation0.69410259
108MP0008789_abnormal_olfactory_epithelium0.69090967
109MP0001661_extended_life_span0.68416228
110MP0005501_abnormal_skin_physiology0.68184873
111MP0000566_synostosis0.65949945
112MP0002653_abnormal_ependyma_morphology0.64948876
113MP0001243_abnormal_dermal_layer0.64654928
114MP0001853_heart_inflammation0.64526792
115MP0002837_dystrophic_cardiac_calcinosis0.62962373
116MP0001286_abnormal_eye_development0.62775087
117MP0005319_abnormal_enzyme/_coenzyme0.62743654
118MP0000627_abnormal_mammary_gland0.62126276
119MP0002177_abnormal_outer_ear0.61814706
120MP0005621_abnormal_cell_physiology0.61268328
121MP0002877_abnormal_melanocyte_morpholog0.61041675
122MP0003195_calcinosis0.60728036
123MP0005330_cardiomyopathy0.60325160
124MP0005023_abnormal_wound_healing0.60312088
125MP0002234_abnormal_pharynx_morphology0.60176290
126MP0003936_abnormal_reproductive_system0.60167862
127MP0001346_abnormal_lacrimal_gland0.58957500
128MP0003755_abnormal_palate_morphology0.58687801
129MP0003121_genomic_imprinting0.58613373
130MP0002163_abnormal_gland_morphology0.57429443
131MP0005391_vision/eye_phenotype0.57025196
132MP0000598_abnormal_liver_morphology0.56933846
133MP0003938_abnormal_ear_development0.56800622
134MP0000689_abnormal_spleen_morphology0.56796671
135MP0002722_abnormal_immune_system0.56201139
136MP0003656_abnormal_erythrocyte_physiolo0.54202390

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.91850583
2Breast hypoplasia (HP:0003187)4.62309516
3Rough bone trabeculation (HP:0100670)3.72338745
4Cerebral hypomyelination (HP:0006808)3.67622042
5Oral leukoplakia (HP:0002745)3.67179579
6Carpal bone hypoplasia (HP:0001498)3.60275903
7Increased serum pyruvate (HP:0003542)3.41935167
8Abnormality of glycolysis (HP:0004366)3.41935167
9Progressive macrocephaly (HP:0004481)3.21415026
10Degeneration of anterior horn cells (HP:0002398)3.06222380
11Abnormality of the anterior horn cell (HP:0006802)3.06222380
12Patellar aplasia (HP:0006443)2.95910853
13Ependymoma (HP:0002888)2.94036403
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.93496987
15Abnormal lung lobation (HP:0002101)2.90170876
16Hyperglycinemia (HP:0002154)2.88632315
17Impulsivity (HP:0100710)2.88028869
18Aplasia/Hypoplasia of the patella (HP:0006498)2.87234480
19Secondary amenorrhea (HP:0000869)2.83955980
20Reticulocytopenia (HP:0001896)2.83142719
21Megaloblastic anemia (HP:0001889)2.82666233
22Macrocytic anemia (HP:0001972)2.79444818
23Absent radius (HP:0003974)2.79428068
24Abnormal trabecular bone morphology (HP:0100671)2.75399500
25Trismus (HP:0000211)2.70249325
26Duodenal stenosis (HP:0100867)2.68905451
27Small intestinal stenosis (HP:0012848)2.68905451
28Increased serum lactate (HP:0002151)2.68069932
29Cerebral edema (HP:0002181)2.66017844
30Multiple enchondromatosis (HP:0005701)2.65350511
313-Methylglutaconic aciduria (HP:0003535)2.62033537
32Aplasia involving forearm bones (HP:0009822)2.59917288
33Absent forearm bone (HP:0003953)2.59917288
34Abnormality of the labia minora (HP:0012880)2.57703731
35Abnormality of cells of the erythroid lineage (HP:0012130)2.56594544
36Premature ovarian failure (HP:0008209)2.54465525
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52659722
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.51437899
39Abnormality of serum amino acid levels (HP:0003112)2.50683526
40Irregular epiphyses (HP:0010582)2.49612705
41Chromsome breakage (HP:0040012)2.48602916
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.47553603
43Abnormal number of erythroid precursors (HP:0012131)2.44165609
44Neoplasm of the adrenal gland (HP:0100631)2.44113516
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43564644
46Abnormality of alanine metabolism (HP:0010916)2.43564644
47Hyperalaninemia (HP:0003348)2.43564644
48Sparse eyelashes (HP:0000653)2.43149513
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41438758
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41438758
51Abnormality of the preputium (HP:0100587)2.40935083
52Abnormality of pyrimidine metabolism (HP:0004353)2.39826516
53Hepatic necrosis (HP:0002605)2.39511260
54Hepatocellular necrosis (HP:0001404)2.38912758
55Microvesicular hepatic steatosis (HP:0001414)2.38075598
56Nephroblastoma (Wilms tumor) (HP:0002667)2.33389946
57Abnormality of the umbilical cord (HP:0010881)2.32869029
58Abnormality of the duodenum (HP:0002246)2.32661961
59Meckel diverticulum (HP:0002245)2.32574786
60Glioma (HP:0009733)2.32169614
61Hyperglycinuria (HP:0003108)2.30758357
62Selective tooth agenesis (HP:0001592)2.29776099
63Increased CSF lactate (HP:0002490)2.29319495
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28756055
65Premature graying of hair (HP:0002216)2.27338795
66Horseshoe kidney (HP:0000085)2.27052862
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26473101
68Volvulus (HP:0002580)2.21823355
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21624936
70Embryonal renal neoplasm (HP:0011794)2.21387111
71Methylmalonic acidemia (HP:0002912)2.19736588
72Nausea (HP:0002018)2.18832097
73Abnormality of the ileum (HP:0001549)2.18359752
74Mitochondrial inheritance (HP:0001427)2.17854083
75Prolonged neonatal jaundice (HP:0006579)2.17679193
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17335130
77Abnormal protein N-linked glycosylation (HP:0012347)2.17335130
78Abnormal protein glycosylation (HP:0012346)2.17335130
79Abnormal glycosylation (HP:0012345)2.17335130
80Hypobetalipoproteinemia (HP:0003563)2.17289045
81Reduced antithrombin III activity (HP:0001976)2.16656125
82Cellular immunodeficiency (HP:0005374)2.15920371
83Methylmalonic aciduria (HP:0012120)2.13493264
84Renal Fanconi syndrome (HP:0001994)2.13255942
85Exercise intolerance (HP:0003546)2.13188046
86Microretrognathia (HP:0000308)2.13115575
87Astrocytoma (HP:0009592)2.12702613
88Abnormality of the astrocytes (HP:0100707)2.12702613
89Cleft eyelid (HP:0000625)2.12320302
90Respiratory failure (HP:0002878)2.11635220
91Absent thumb (HP:0009777)2.11599986
92Acute necrotizing encephalopathy (HP:0006965)2.11472127
93Abnormality of serine family amino acid metabolism (HP:0010894)2.11028186
94Abnormality of glycine metabolism (HP:0010895)2.11028186
95Ureteral duplication (HP:0000073)2.08994418
96Bone marrow hypocellularity (HP:0005528)2.08507147
97Abnormalities of placenta or umbilical cord (HP:0001194)2.06206458
98Hypoplastic pelvis (HP:0008839)2.06042705
99Lethargy (HP:0001254)2.05640782
100Rhabdomyosarcoma (HP:0002859)2.05502851
101Aplastic anemia (HP:0001915)2.05039161
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.04517438
103Hypoplasia of the fovea (HP:0007750)2.04517438
104CNS hypomyelination (HP:0003429)2.04392565
105Increased hepatocellular lipid droplets (HP:0006565)2.04255116
106Leukodystrophy (HP:0002415)2.03741991
107Pancytopenia (HP:0001876)2.02485722
108CNS demyelination (HP:0007305)2.02275129
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01854630
110Sloping forehead (HP:0000340)2.01536407
111Myelodysplasia (HP:0002863)2.00121861
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99962786
113Type 2 muscle fiber atrophy (HP:0003554)1.99335970
114Poor head control (HP:0002421)1.97501082
115Muscle fiber atrophy (HP:0100295)1.95298390
116Abnormal mitochondria in muscle tissue (HP:0008316)1.95030243
117Neoplasm of the pancreas (HP:0002894)1.94466640
118Lactic acidosis (HP:0003128)1.94424665
119Lipid accumulation in hepatocytes (HP:0006561)1.94361951
120Abnormality of the fovea (HP:0000493)1.93656325
121Pancreatic islet-cell hyperplasia (HP:0004510)1.92742617
122Facial cleft (HP:0002006)1.92697010
123Amniotic constriction ring (HP:0009775)1.91841034
124Abnormality of placental membranes (HP:0011409)1.91841034
125Progressive muscle weakness (HP:0003323)1.91315696
126Triphalangeal thumb (HP:0001199)1.91290712
127Pallor (HP:0000980)1.90895777
128Supernumerary spleens (HP:0009799)1.90513870
129Abnormality of methionine metabolism (HP:0010901)1.90509822
130Postnatal microcephaly (HP:0005484)1.90495425
131Cortical dysplasia (HP:0002539)1.90170006
132Acute encephalopathy (HP:0006846)1.89742285
133Neoplasm of the colon (HP:0100273)1.88902770
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88822334
135Cholecystitis (HP:0001082)1.87312026
136Abnormal gallbladder physiology (HP:0012438)1.87312026
137Abnormality of chromosome stability (HP:0003220)1.87279271
138Type I transferrin isoform profile (HP:0003642)1.86034408
139Colon cancer (HP:0003003)1.85089141
140Abnormal spermatogenesis (HP:0008669)1.84125194
141Increased nuchal translucency (HP:0010880)1.82206174
142Sensory axonal neuropathy (HP:0003390)1.81556651
143Spastic diplegia (HP:0001264)1.80943870
144Clubbing of toes (HP:0100760)1.79549525
145Prominent metopic ridge (HP:0005487)1.76713374
146Bifid tongue (HP:0010297)1.75964554
147Abnormality of the carotid arteries (HP:0005344)1.74955839
148Abnormal auditory evoked potentials (HP:0006958)1.74735192
149Patchy hypopigmentation of hair (HP:0011365)1.74503611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.46475565
2EIF2AK14.25819357
3WEE14.13893234
4VRK23.02549460
5STK162.88151703
6PLK42.85823903
7TRIM282.85312823
8TSSK62.84173967
9EIF2AK32.65423722
10NME22.57062129
11SRPK12.47560044
12CDC72.43958105
13EPHA22.33857258
14PBK2.14047868
15NUAK12.04572104
16NEK12.03607739
17MKNK12.00835180
18TTK1.90097830
19TESK21.85186838
20ACVR1B1.83037885
21PLK11.79977811
22MKNK21.77103626
23PLK31.71321362
24VRK11.71223437
25BRSK21.70690464
26NME11.66077233
27PIM21.56903309
28TLK11.48243046
29ZAK1.47391828
30AURKA1.41290812
31STK38L1.37554805
32NEK21.37428903
33IRAK31.33878689
34CDK71.33636002
35TAF11.28895327
36AURKB1.28261416
37PNCK1.26573451
38BCKDK1.24897683
39AKT31.21193769
40DYRK31.20326668
41WNK31.20302694
42SIK31.15823769
43TNIK1.15075630
44EIF2AK21.13124793
45RPS6KB21.12658410
46RPS6KA41.08791229
47CHEK21.07963002
48MAP3K31.06327183
49ERBB31.05084369
50ATR1.04187631
51BRSK10.98657360
52KDR0.97613059
53CCNB10.97605555
54CSNK1G10.92090857
55MST1R0.90608268
56MAP3K80.86664654
57MAP4K20.86020216
58CHEK10.84179305
59MAP3K110.82659737
60BRAF0.81456385
61MAP2K30.80167404
62CDK40.79966635
63PAK40.78644591
64PRKCI0.78317761
65MAP3K120.76722426
66NEK90.75909691
67DYRK20.74975137
68CSNK1A1L0.74876180
69CSNK2A10.74869474
70ABL20.73144469
71STK40.72033652
72PASK0.71881318
73STK100.71737372
74DAPK10.71105447
75CSNK2A20.71075041
76CDK80.69137840
77LATS20.68491558
78CSNK1G20.68293119
79PAK10.67533247
80PIM10.66804559
81TAOK20.65324085
82PDK40.64754554
83PDK30.64754554
84CDK120.62806262
85MST40.60289850
86CDK20.56417686
87PDK20.55962509
88ALK0.54822350
89BCR0.53660083
90FER0.51802223
91FGFR10.51716732
92TESK10.49989204
93ATM0.48247119
94LIMK10.45801016
95STK240.44257921
96OXSR10.44085427
97CLK10.43366064
98RPS6KA50.43260566
99CDK10.42796284
100TGFBR10.41063872
101LATS10.40673701
102ARAF0.39901854
103INSRR0.39672535
104FRK0.39604066
105STK390.37815690
106MINK10.37528840
107CSNK1E0.37307123
108ERBB40.36923918
109PLK20.35841214
110STK30.32559337
111MELK0.32024153
112IRAK40.30056161
113AKT20.26446569
114MAPKAPK30.25633500
115MAP3K50.24881496
116MARK30.24559517
117PAK30.24402555
118CSNK1G30.24368493
119OBSCN0.24253851
120CDK30.23310299
121MAPKAPK50.23285754
122GRK10.22821701
123CDK90.21079693
124BLK0.20984106
125PRKDC0.20674841
126MET0.20482522
127MAP2K70.19782207
128BRD40.19727373
129CSNK1A10.19448117
130SCYL20.18966365
131CDK60.18680094
132BMPR1B0.18208371
133ZAP700.16890894
134YES10.15137509
135NLK0.14952924

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030504.76569190
2RNA polymerase_Homo sapiens_hsa030203.71014087
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68693746
4DNA replication_Homo sapiens_hsa030303.61082362
5Mismatch repair_Homo sapiens_hsa034303.24355791
6Ribosome_Homo sapiens_hsa030103.00781212
7RNA transport_Homo sapiens_hsa030132.73472974
8Spliceosome_Homo sapiens_hsa030402.68150469
9Pyrimidine metabolism_Homo sapiens_hsa002402.50904904
10One carbon pool by folate_Homo sapiens_hsa006702.45530020
11Homologous recombination_Homo sapiens_hsa034402.40600076
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34984519
13Nucleotide excision repair_Homo sapiens_hsa034202.32172233
14Base excision repair_Homo sapiens_hsa034102.15723617
15Vitamin B6 metabolism_Homo sapiens_hsa007502.00825093
16Cell cycle_Homo sapiens_hsa041101.97098232
17Basal transcription factors_Homo sapiens_hsa030221.79840780
18Fanconi anemia pathway_Homo sapiens_hsa034601.63707552
19Folate biosynthesis_Homo sapiens_hsa007901.60963051
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59459863
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.44350472
22RNA degradation_Homo sapiens_hsa030181.44314595
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37140527
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36707051
25Non-homologous end-joining_Homo sapiens_hsa034501.35430196
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.33209534
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32532755
28Purine metabolism_Homo sapiens_hsa002301.30413146
29p53 signaling pathway_Homo sapiens_hsa041151.30029649
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26846992
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22409436
32Oxidative phosphorylation_Homo sapiens_hsa001901.20502595
33Biosynthesis of amino acids_Homo sapiens_hsa012301.18941353
34Pentose phosphate pathway_Homo sapiens_hsa000301.17542237
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14279199
36Protein export_Homo sapiens_hsa030601.13683842
37Selenocompound metabolism_Homo sapiens_hsa004501.12679662
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09363285
39* Epstein-Barr virus infection_Homo sapiens_hsa051691.06214944
40Parkinsons disease_Homo sapiens_hsa050121.05818630
41Glutathione metabolism_Homo sapiens_hsa004801.02701664
42Carbon metabolism_Homo sapiens_hsa012001.02341065
43Huntingtons disease_Homo sapiens_hsa050161.02078366
44mRNA surveillance pathway_Homo sapiens_hsa030151.00717570
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92336560
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89874476
47Sulfur relay system_Homo sapiens_hsa041220.87802458
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.85936082
49Sulfur metabolism_Homo sapiens_hsa009200.81015475
50Steroid biosynthesis_Homo sapiens_hsa001000.79709131
51Regulation of autophagy_Homo sapiens_hsa041400.78984854
52Fructose and mannose metabolism_Homo sapiens_hsa000510.73474060
53N-Glycan biosynthesis_Homo sapiens_hsa005100.69987798
54Arginine and proline metabolism_Homo sapiens_hsa003300.69390352
55Fatty acid elongation_Homo sapiens_hsa000620.67760141
56Metabolic pathways_Homo sapiens_hsa011000.65246746
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62262345
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60147257
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56932375
60Peroxisome_Homo sapiens_hsa041460.54731457
61Vitamin digestion and absorption_Homo sapiens_hsa049770.54504330
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54205274
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53817885
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52972297
65Pyruvate metabolism_Homo sapiens_hsa006200.51320494
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50971419
67Arachidonic acid metabolism_Homo sapiens_hsa005900.50490941
68Retinol metabolism_Homo sapiens_hsa008300.48059130
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46603407
70beta-Alanine metabolism_Homo sapiens_hsa004100.45553311
71Phenylalanine metabolism_Homo sapiens_hsa003600.45102515
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44104032
73Herpes simplex infection_Homo sapiens_hsa051680.43881632
74Oocyte meiosis_Homo sapiens_hsa041140.43177975
75Propanoate metabolism_Homo sapiens_hsa006400.42613502
76Tyrosine metabolism_Homo sapiens_hsa003500.42454105
77Alzheimers disease_Homo sapiens_hsa050100.40791002
78Legionellosis_Homo sapiens_hsa051340.40227295
79Antigen processing and presentation_Homo sapiens_hsa046120.39382454
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.39306870
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39191125
82Galactose metabolism_Homo sapiens_hsa000520.38773298
83Systemic lupus erythematosus_Homo sapiens_hsa053220.38154540
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36338436
85Linoleic acid metabolism_Homo sapiens_hsa005910.36317127
86Chemical carcinogenesis_Homo sapiens_hsa052040.35533830
87Viral carcinogenesis_Homo sapiens_hsa052030.34533666
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33786124
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31351001
90Tryptophan metabolism_Homo sapiens_hsa003800.29100874
91Fatty acid degradation_Homo sapiens_hsa000710.29067171
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27922916
93Cardiac muscle contraction_Homo sapiens_hsa042600.26829806
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26184135
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25270773
96TGF-beta signaling pathway_Homo sapiens_hsa043500.23849512
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.23710905
98Hippo signaling pathway_Homo sapiens_hsa043900.23159700
99Collecting duct acid secretion_Homo sapiens_hsa049660.23019935
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22155855
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21764676
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21541055
103Lysine degradation_Homo sapiens_hsa003100.21009349
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20731947
105Vibrio cholerae infection_Homo sapiens_hsa051100.20638598
106Caffeine metabolism_Homo sapiens_hsa002320.19135812
107Phototransduction_Homo sapiens_hsa047440.18770490
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18171150
109Butanoate metabolism_Homo sapiens_hsa006500.18064005
110Histidine metabolism_Homo sapiens_hsa003400.17272366
111Fatty acid metabolism_Homo sapiens_hsa012120.16848824
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14010694
113Arginine biosynthesis_Homo sapiens_hsa002200.11326067
114Tight junction_Homo sapiens_hsa045300.09220112

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