PSMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.34358419
2ATP synthesis coupled proton transport (GO:0015986)5.05070768
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.05070768
4* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.49821584
5formation of translation preinitiation complex (GO:0001731)4.43720636
6proteasome assembly (GO:0043248)4.40801403
7binding of sperm to zona pellucida (GO:0007339)4.39472155
8* negative regulation of ligase activity (GO:0051352)4.32042888
9* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.32042888
10sperm-egg recognition (GO:0035036)4.31952943
11regulation of mitochondrial translation (GO:0070129)4.31025815
12protein maturation by protein folding (GO:0022417)4.29056319
13fusion of sperm to egg plasma membrane (GO:0007342)4.26832728
14* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.21578251
15* regulation of cellular amino acid metabolic process (GO:0006521)4.17891249
16* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.16697159
17* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.12407814
18* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.09707776
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.07315889
20viral transcription (GO:0019083)4.05962258
21translational termination (GO:0006415)4.01419058
22* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.01358729
23* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.01358729
24nucleobase-containing small molecule interconversion (GO:0015949)3.99695967
25ribosomal small subunit biogenesis (GO:0042274)3.94868882
26* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.94729280
27* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.94729280
28* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.94729280
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94132704
30* signal transduction involved in DNA damage checkpoint (GO:0072422)3.92791587
31* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.92791587
32ribosomal small subunit assembly (GO:0000028)3.92133928
33ribosomal large subunit biogenesis (GO:0042273)3.91577194
34DNA strand elongation involved in DNA replication (GO:0006271)3.88740773
35* signal transduction involved in cell cycle checkpoint (GO:0072395)3.86031242
36cullin deneddylation (GO:0010388)3.84703515
37translational elongation (GO:0006414)3.82836862
38establishment of integrated proviral latency (GO:0075713)3.80774296
39cell-cell recognition (GO:0009988)3.75720122
40* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73531568
41chaperone-mediated protein transport (GO:0072321)3.71830599
42chaperone-mediated protein complex assembly (GO:0051131)3.69433819
43DNA replication-dependent nucleosome assembly (GO:0006335)3.68781416
44DNA replication-dependent nucleosome organization (GO:0034723)3.68781416
45mitotic metaphase plate congression (GO:0007080)3.65285909
46maturation of SSU-rRNA (GO:0030490)3.63411307
47translational initiation (GO:0006413)3.62867143
48DNA strand elongation (GO:0022616)3.62388000
49* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.60981326
50telomere maintenance via recombination (GO:0000722)3.60909021
51* positive regulation of ligase activity (GO:0051351)3.57971214
52* regulation of ubiquitin-protein transferase activity (GO:0051438)3.52348062
53DNA unwinding involved in DNA replication (GO:0006268)3.51936783
54mitotic sister chromatid segregation (GO:0000070)3.49270327
55protein deneddylation (GO:0000338)3.46801127
56DNA replication initiation (GO:0006270)3.45578533
57mitotic recombination (GO:0006312)3.45510256
58peptidyl-arginine omega-N-methylation (GO:0035247)3.45323106
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43994061
60cellular protein complex disassembly (GO:0043624)3.42867861
61respiratory electron transport chain (GO:0022904)3.42256066
62spliceosomal snRNP assembly (GO:0000387)3.41840238
63mitotic chromosome condensation (GO:0007076)3.41642194
64* regulation of ligase activity (GO:0051340)3.40167548
65electron transport chain (GO:0022900)3.37401469
66cotranslational protein targeting to membrane (GO:0006613)3.36885417
67translation (GO:0006412)3.36406112
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35455831
69nucleobase biosynthetic process (GO:0046112)3.35422995
70tricarboxylic acid cycle (GO:0006099)3.33086297
71protein targeting to ER (GO:0045047)3.32182912
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31697764
73* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29989257
74sperm motility (GO:0030317)3.29218179
75histone arginine methylation (GO:0034969)3.29107465
76protein neddylation (GO:0045116)3.26920997
77* positive regulation of cell cycle arrest (GO:0071158)3.26011658
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.23743331
79ribosome assembly (GO:0042255)3.23563577
80viral life cycle (GO:0019058)3.23308087
81ribonucleoprotein complex biogenesis (GO:0022613)3.21715871
82transcription-coupled nucleotide-excision repair (GO:0006283)3.19523844
83DNA deamination (GO:0045006)3.19432393
84plasma membrane fusion (GO:0045026)3.19422223
85protein localization to endoplasmic reticulum (GO:0070972)3.19317109
86oxidative phosphorylation (GO:0006119)3.18988743
87purine nucleobase biosynthetic process (GO:0009113)3.17866213
88nuclear envelope reassembly (GO:0031468)3.17789160
89mitotic nuclear envelope reassembly (GO:0007084)3.17789160
90COPI coating of Golgi vesicle (GO:0048205)3.17785981
91Golgi transport vesicle coating (GO:0048200)3.17785981
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17771623
93establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15989072
94pseudouridine synthesis (GO:0001522)3.14827912
95ATP biosynthetic process (GO:0006754)3.14687765
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14630197
97GTP biosynthetic process (GO:0006183)3.14428709
98deoxyribonucleotide biosynthetic process (GO:0009263)3.14053959
99establishment of viral latency (GO:0019043)3.14047783
1007-methylguanosine mRNA capping (GO:0006370)3.13926600
101telomere maintenance via semi-conservative replication (GO:0032201)3.13687973
102* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.13583351
103protein localization to mitochondrion (GO:0070585)3.13327403
104establishment of protein localization to mitochondrion (GO:0072655)3.13323721
105piRNA metabolic process (GO:0034587)3.13206946
106cilium or flagellum-dependent cell motility (GO:0001539)3.12791692
107CENP-A containing nucleosome assembly (GO:0034080)3.12729624
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.12727116
109UTP biosynthetic process (GO:0006228)3.12292167
110purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11403995
111telomere maintenance via telomere lengthening (GO:0010833)3.10611695
112ribosome biogenesis (GO:0042254)3.09173026
113inner mitochondrial membrane organization (GO:0007007)3.08417566
114chromatin remodeling at centromere (GO:0031055)3.07904303
115* regulation of cellular amine metabolic process (GO:0033238)3.07247266
116transcription elongation from RNA polymerase III promoter (GO:0006385)3.06949340
117termination of RNA polymerase III transcription (GO:0006386)3.06949340
118rRNA modification (GO:0000154)3.06297995
119metaphase plate congression (GO:0051310)3.05259116
120protein complex disassembly (GO:0043241)3.05007678
121multicellular organism reproduction (GO:0032504)3.04528531
1227-methylguanosine RNA capping (GO:0009452)3.03467167
123RNA capping (GO:0036260)3.03467167
124protein localization to chromosome, centromeric region (GO:0071459)3.02511302
125* G1/S transition of mitotic cell cycle (GO:0000082)3.01555920
126* cell cycle G1/S phase transition (GO:0044843)3.01555920
127de novo protein folding (GO:0006458)3.01508397
128acrosome assembly (GO:0001675)3.01254326
129nucleotide-excision repair, DNA gap filling (GO:0006297)3.01140580
130protein localization to kinetochore (GO:0034501)2.99666534
131base-excision repair (GO:0006284)2.99570841
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98668680
133sister chromatid segregation (GO:0000819)2.97954319
134protein targeting to mitochondrion (GO:0006626)2.97511924
135synaptonemal complex organization (GO:0070193)2.96798263
136viral mRNA export from host cell nucleus (GO:0046784)2.95889029
137tRNA aminoacylation for protein translation (GO:0006418)2.94769917
138* negative regulation of protein ubiquitination (GO:0031397)2.92875291
139pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92771276
140pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92584471
141guanosine-containing compound biosynthetic process (GO:1901070)2.91913737
142de novo posttranslational protein folding (GO:0051084)2.91017543
143rRNA processing (GO:0006364)2.90681424
144DNA ligation (GO:0006266)2.88522320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.76980198
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49764565
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.20536173
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.08671408
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93391360
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64871298
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.57781604
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55479774
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.51310527
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44231286
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.40897401
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38607468
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07742448
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88296386
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81462971
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77984830
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76688156
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73864534
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71363072
20XRN2_22483619_ChIP-Seq_HELA_Human2.51539948
21* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35341262
22DCP1A_22483619_ChIP-Seq_HELA_Human2.30146876
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.29086032
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27869418
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25474769
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25339952
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23603247
28VDR_23849224_ChIP-Seq_CD4+_Human2.12831148
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12054927
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05490106
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02136650
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.99381130
33GABP_19822575_ChIP-Seq_HepG2_Human1.97263416
34AR_21909140_ChIP-Seq_LNCAP_Human1.89277122
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.88589091
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.84226803
37TTF2_22483619_ChIP-Seq_HELA_Human1.76715990
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76238557
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72948598
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64599520
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62002733
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61594756
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59013415
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43076069
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42693587
46ELK1_19687146_ChIP-ChIP_HELA_Human1.40622024
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38929051
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35777758
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35143416
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31511111
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29298213
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.27627194
53* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27242467
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25160271
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23692676
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23516688
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23170217
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22820215
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21719801
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21490619
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21135112
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20412603
63* KDM5A_27292631_Chip-Seq_BREAST_Human1.18690965
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17258270
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13899098
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11252786
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10075657
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.09187098
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08350762
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07338027
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06859053
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06543169
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06517495
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.04815892
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04677444
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02312226
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00740715
78ZNF263_19887448_ChIP-Seq_K562_Human1.00063756
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99864814
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99708367
81CIITA_25753668_ChIP-Seq_RAJI_Human0.99465327
82CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98603851
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96320108
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94999998
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93614484
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.93579170
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93362317
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91791474
89SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91570034
90* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90661578
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90443413
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90007385
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89595698
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89256477
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88470377
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87833867
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87585213
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85643694
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.85369996
100TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84938830
101RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84453560
102MYC_18940864_ChIP-ChIP_HL60_Human0.84063863
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83620542
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83473500
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79101694
106TFEB_21752829_ChIP-Seq_HELA_Human0.78339606
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73900862
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72863325
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71844570
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70955983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.54603068
2MP0003806_abnormal_nucleotide_metabolis4.29563883
3MP0004957_abnormal_blastocyst_morpholog3.67732482
4MP0003693_abnormal_embryo_hatching3.38600764
5MP0010094_abnormal_chromosome_stability2.92667225
6MP0008932_abnormal_embryonic_tissue2.72839850
7MP0003077_abnormal_cell_cycle2.72678207
8MP0008877_abnormal_DNA_methylation2.69456485
9MP0003111_abnormal_nucleus_morphology2.62062593
10MP0008058_abnormal_DNA_repair2.43833630
11MP0000749_muscle_degeneration2.39097291
12MP0004084_abnormal_cardiac_muscle2.37494454
13MP0006036_abnormal_mitochondrial_physio2.30035750
14MP0002653_abnormal_ependyma_morphology2.27376582
15* MP0001730_embryonic_growth_arrest2.22724810
16MP0008057_abnormal_DNA_replication2.20763147
17MP0003646_muscle_fatigue2.19709413
18MP0003950_abnormal_plasma_membrane2.17799646
19MP0004036_abnormal_muscle_relaxation2.17397323
20MP0001929_abnormal_gametogenesis2.14976531
21MP0003698_abnormal_male_reproductive2.12680108
22MP0000751_myopathy2.10538125
23MP0010030_abnormal_orbit_morphology2.03233194
24MP0006035_abnormal_mitochondrial_morpho2.02914717
25MP0001529_abnormal_vocalization1.99857568
26MP0002877_abnormal_melanocyte_morpholog1.90360171
27MP0009697_abnormal_copulation1.74981946
28MP0000750_abnormal_muscle_regeneration1.72965454
29MP0002210_abnormal_sex_determination1.70538573
30MP0008007_abnormal_cellular_replicative1.69035665
31MP0002837_dystrophic_cardiac_calcinosis1.67314905
32MP0008438_abnormal_cutaneous_collagen1.65287938
33MP0000747_muscle_weakness1.63620109
34MP0002269_muscular_atrophy1.61775998
35MP0003786_premature_aging1.60173086
36MP0008789_abnormal_olfactory_epithelium1.58116845
37MP0003186_abnormal_redox_activity1.56060447
38MP0000358_abnormal_cell_content/1.53377706
39MP0001145_abnormal_male_reproductive1.52456271
40MP0005330_cardiomyopathy1.50288970
41MP0003221_abnormal_cardiomyocyte_apopto1.45503950
42MP0005501_abnormal_skin_physiology1.41678702
43MP0003718_maternal_effect1.36912663
44MP0001697_abnormal_embryo_size1.29786439
45MP0002106_abnormal_muscle_physiology1.29768379
46MP0004145_abnormal_muscle_electrophysio1.29366590
47* MP0002080_prenatal_lethality1.28058365
48MP0000350_abnormal_cell_proliferation1.27825626
49MP0004233_abnormal_muscle_weight1.26144341
50MP0005623_abnormal_meninges_morphology1.26069064
51MP0002161_abnormal_fertility/fecundity1.25089294
52MP0002160_abnormal_reproductive_system1.24803299
53MP0000537_abnormal_urethra_morphology1.24327652
54MP0009672_abnormal_birth_weight1.24023915
55MP0004087_abnormal_muscle_fiber1.22983194
56MP0003941_abnormal_skin_development1.21862468
57* MP0001727_abnormal_embryo_implantation1.20373878
58MP0000653_abnormal_sex_gland1.18985253
59MP0005266_abnormal_metabolism1.16561517
60MP0003315_abnormal_perineum_morphology1.16175947
61MP0000490_abnormal_crypts_of1.14134517
62MP0000759_abnormal_skeletal_muscle1.11064381
63MP0005451_abnormal_body_composition1.11042166
64MP0000313_abnormal_cell_death1.10502489
65MP0005394_taste/olfaction_phenotype1.08668623
66MP0005499_abnormal_olfactory_system1.08668623
67MP0005380_embryogenesis_phenotype1.07132841
68MP0001672_abnormal_embryogenesis/_devel1.07132841
69MP0003984_embryonic_growth_retardation1.06473801
70MP0001661_extended_life_span1.06329202
71MP0001243_abnormal_dermal_layer1.05564080
72MP0002088_abnormal_embryonic_growth/wei1.01970782
73MP0004215_abnormal_myocardial_fiber1.01769295
74MP0001905_abnormal_dopamine_level1.01528921
75MP0004147_increased_porphyrin_level1.01488666
76MP0005369_muscle_phenotype1.01229844
77MP0000372_irregular_coat_pigmentation1.00776298
78MP0002085_abnormal_embryonic_tissue1.00215240
79MP0001293_anophthalmia0.98555659
80MP0006292_abnormal_olfactory_placode0.98344701
81MP0003385_abnormal_body_wall0.95804198
82MP0009053_abnormal_anal_canal0.95275215
83MP0003011_delayed_dark_adaptation0.95255749
84MP0003329_amyloid_beta_deposits0.94831359
85MP0004272_abnormal_basement_membrane0.94415396
86MP0003567_abnormal_fetal_cardiomyocyte0.94093290
87MP0003123_paternal_imprinting0.93961878
88MP0003705_abnormal_hypodermis_morpholog0.92845307
89MP0000762_abnormal_tongue_morphology0.91974514
90MP0002282_abnormal_trachea_morphology0.90932201
91MP0001881_abnormal_mammary_gland0.90697022
92MP0000579_abnormal_nail_morphology0.90636286
93MP0002060_abnormal_skin_morphology0.90129181
94MP0004197_abnormal_fetal_growth/weight/0.89723691
95MP0001346_abnormal_lacrimal_gland0.89592577
96MP0005257_abnormal_intraocular_pressure0.88703559
97MP0009379_abnormal_foot_pigmentation0.87668589
98MP0008260_abnormal_autophagy0.87493217
99MP0002111_abnormal_tail_morphology0.85984096
100MP0004133_heterotaxia0.83838180
101MP0004185_abnormal_adipocyte_glucose0.82101341
102MP0005384_cellular_phenotype0.81489952
103MP0002796_impaired_skin_barrier0.81316459
104MP0000049_abnormal_middle_ear0.80943099
105MP0002697_abnormal_eye_size0.80758786
106MP0001853_heart_inflammation0.80577320
107MP0002234_abnormal_pharynx_morphology0.78356751
108MP0005620_abnormal_muscle_contractility0.77137800
109MP0004134_abnormal_chest_morphology0.76215805
110MP0002084_abnormal_developmental_patter0.75964128
111MP0000467_abnormal_esophagus_morphology0.74464818
112MP0003942_abnormal_urinary_system0.71885005
113MP0001542_abnormal_bone_strength0.71791060
114MP0002938_white_spotting0.70703008
115MP0006054_spinal_hemorrhage0.70394880
116MP0001544_abnormal_cardiovascular_syste0.70276452
117MP0005385_cardiovascular_system_phenoty0.70276452
118MP0001299_abnormal_eye_distance/0.69986469
119MP0003566_abnormal_cell_adhesion0.68726741
120MP0003937_abnormal_limbs/digits/tail_de0.68230952
121MP0000647_abnormal_sebaceous_gland0.67198518
122MP0008775_abnormal_heart_ventricle0.67071939
123MP0003656_abnormal_erythrocyte_physiolo0.66185949
124MP0000627_abnormal_mammary_gland0.66169216
125MP0002019_abnormal_tumor_incidence0.66057623
126MP0005023_abnormal_wound_healing0.65880407
127MP0005165_increased_susceptibility_to0.64771823
128MP0001915_intracranial_hemorrhage0.64745404
129MP0002086_abnormal_extraembryonic_tissu0.63986097
130MP0010630_abnormal_cardiac_muscle0.63904241
131MP0010307_abnormal_tumor_latency0.63374126
132MP0000920_abnormal_myelination0.62824413
133MP0010234_abnormal_vibrissa_follicle0.62521837
134MP0002092_abnormal_eye_morphology0.61554872
135MP0010771_integument_phenotype0.61369617
136MP0001764_abnormal_homeostasis0.61104670
137MP0005376_homeostasis/metabolism_phenot0.60921684
138MP0006138_congestive_heart_failure0.58209429
139MP0005389_reproductive_system_phenotype0.57572743
140MP0002972_abnormal_cardiac_muscle0.57041390
141MP0000733_abnormal_muscle_development0.56909568
142MP0001849_ear_inflammation0.56682605
143MP0005377_hearing/vestibular/ear_phenot0.55599669
144MP0003878_abnormal_ear_physiology0.55599669
145MP0009333_abnormal_splenocyte_physiolog0.54323335

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)5.26246603
2Increased serum pyruvate (HP:0003542)5.26246603
3Acute necrotizing encephalopathy (HP:0006965)4.89404052
4Abnormal mitochondria in muscle tissue (HP:0008316)4.59839999
5Cerebral hypomyelination (HP:0006808)4.27511107
6Abnormality of cells of the erythroid lineage (HP:0012130)4.23254174
7Mitochondrial inheritance (HP:0001427)4.10408541
8Acute encephalopathy (HP:0006846)4.03429592
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.89148527
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.77267377
11Absent/shortened dynein arms (HP:0200106)3.77267377
12Hepatocellular necrosis (HP:0001404)3.75954757
13Increased CSF lactate (HP:0002490)3.75419487
14Progressive macrocephaly (HP:0004481)3.68075481
15Abnormal number of erythroid precursors (HP:0012131)3.61597648
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.59378124
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.59378124
18Hepatic necrosis (HP:0002605)3.40177244
19Ragged-red muscle fibers (HP:0003200)3.40110434
20Leukodystrophy (HP:0002415)3.23161156
21Cerebral edema (HP:0002181)3.12980696
22Increased hepatocellular lipid droplets (HP:0006565)3.09546108
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04706152
24Lipid accumulation in hepatocytes (HP:0006561)3.04271428
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03966683
26Increased serum lactate (HP:0002151)3.03589450
27Hypoplasia of the capital femoral epiphysis (HP:0003090)3.00054201
28Exercise intolerance (HP:0003546)2.97459855
29Abnormal respiratory epithelium morphology (HP:0012253)2.94340680
30Abnormal respiratory motile cilium morphology (HP:0005938)2.94340680
31Rhabdomyolysis (HP:0003201)2.94079757
32Respiratory failure (HP:0002878)2.87563958
33Selective tooth agenesis (HP:0001592)2.79805198
34Muscle fiber splitting (HP:0003555)2.79476610
35Lactic acidosis (HP:0003128)2.76794030
36Increased intramyocellular lipid droplets (HP:0012240)2.73402062
37CNS hypomyelination (HP:0003429)2.71002588
38Macrocytic anemia (HP:0001972)2.66238838
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66093649
40Trismus (HP:0000211)2.65886832
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65373663
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55977274
43Exercise-induced muscle cramps (HP:0003710)2.55743583
44Multiple enchondromatosis (HP:0005701)2.54365052
45Type I transferrin isoform profile (HP:0003642)2.53903636
46Increased muscle lipid content (HP:0009058)2.52255350
47Nemaline bodies (HP:0003798)2.50299061
48Breast hypoplasia (HP:0003187)2.49452445
49Muscle fiber inclusion bodies (HP:0100299)2.48140529
50Abnormal respiratory motile cilium physiology (HP:0012261)2.47926626
51Birth length less than 3rd percentile (HP:0003561)2.47352037
52Amniotic constriction ring (HP:0009775)2.46282465
53Abnormality of placental membranes (HP:0011409)2.46282465
54Reticulocytopenia (HP:0001896)2.43316159
553-Methylglutaconic aciduria (HP:0003535)2.39063840
56Emotional lability (HP:0000712)2.38499380
57Respiratory difficulties (HP:0002880)2.36169519
58Chromsome breakage (HP:0040012)2.35688862
59Absent epiphyses (HP:0010577)2.34656027
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34656027
61Chronic bronchitis (HP:0004469)2.34479226
62Insomnia (HP:0100785)2.34386306
63CNS demyelination (HP:0007305)2.29349234
64Optic disc pallor (HP:0000543)2.26969872
65Overriding aorta (HP:0002623)2.26683805
66Testicular atrophy (HP:0000029)2.24015039
67Rhinitis (HP:0012384)2.21941115
68Renal Fanconi syndrome (HP:0001994)2.21724011
69Myoglobinuria (HP:0002913)2.20481596
70Postnatal microcephaly (HP:0005484)2.18775893
71Premature rupture of membranes (HP:0001788)2.17886997
72Spastic diplegia (HP:0001264)2.17372538
73Pancytopenia (HP:0001876)2.17284047
74Delusions (HP:0000746)2.16780746
75Entropion (HP:0000621)2.14895302
76Difficulty climbing stairs (HP:0003551)2.14774475
77Sparse eyelashes (HP:0000653)2.13897468
78Abnormality of the anterior horn cell (HP:0006802)2.13655087
79Degeneration of anterior horn cells (HP:0002398)2.13655087
80Abnormality of the umbilical cord (HP:0010881)2.12262939
81Abnormal trabecular bone morphology (HP:0100671)2.08826377
82Abnormal protein glycosylation (HP:0012346)2.08694702
83Abnormal glycosylation (HP:0012345)2.08694702
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08694702
85Abnormal protein N-linked glycosylation (HP:0012347)2.08694702
86Calcaneovalgus deformity (HP:0001848)2.06318205
87Hyperacusis (HP:0010780)2.05267166
88Shoulder girdle muscle weakness (HP:0003547)2.03135806
89Aplastic anemia (HP:0001915)2.03098362
90Limb-girdle muscle atrophy (HP:0003797)2.00269058
91Carpal bone hypoplasia (HP:0001498)1.99826655
92Oral leukoplakia (HP:0002745)1.99811846
93Rough bone trabeculation (HP:0100670)1.94872186
94Reduced antithrombin III activity (HP:0001976)1.94725741
95Abnormal gallbladder physiology (HP:0012438)1.94373368
96Cholecystitis (HP:0001082)1.94373368
97Hyporeflexia of lower limbs (HP:0002600)1.93299782
98Microvesicular hepatic steatosis (HP:0001414)1.93279854
99Vertebral compression fractures (HP:0002953)1.92358326
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91817303
101Secondary amenorrhea (HP:0000869)1.91277901
102Pallor (HP:0000980)1.90891480
103Broad distal phalanx of finger (HP:0009836)1.90696293
104Hypokinesia (HP:0002375)1.89082897
105Deformed tarsal bones (HP:0008119)1.88811548
106Abnormalities of placenta or umbilical cord (HP:0001194)1.88033329
107Increased nuchal translucency (HP:0010880)1.87876115
108Neuroendocrine neoplasm (HP:0100634)1.87499681
109Opisthotonus (HP:0002179)1.86360816
110Abnormality of the preputium (HP:0100587)1.85635082
111Distal lower limb muscle weakness (HP:0009053)1.85121409
112Horseshoe kidney (HP:0000085)1.83737994
113Abnormal ciliary motility (HP:0012262)1.83407021
114Muscle hypertrophy of the lower extremities (HP:0008968)1.83360905
115Abnormality of dentin (HP:0010299)1.83305054
116Gonadotropin excess (HP:0000837)1.83060431
117Meckel diverticulum (HP:0002245)1.82458010
11811 pairs of ribs (HP:0000878)1.82418514
119Squamous cell carcinoma (HP:0002860)1.82130064
120Exertional dyspnea (HP:0002875)1.80575465
121Muscle stiffness (HP:0003552)1.80383870
122Palpitations (HP:0001962)1.79453132
123Nasal polyposis (HP:0100582)1.79232973
124Progressive muscle weakness (HP:0003323)1.78919257
125Personality changes (HP:0000751)1.77577591
126Achilles tendon contracture (HP:0001771)1.76181411
127Reduced subcutaneous adipose tissue (HP:0003758)1.75998716
128Cortical dysplasia (HP:0002539)1.75110706
129Exercise-induced myalgia (HP:0003738)1.73017614
130Lethargy (HP:0001254)1.72927170
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72873571
132Calf muscle hypertrophy (HP:0008981)1.71845889
133Hypoplastic pelvis (HP:0008839)1.71373871
134Facial cleft (HP:0002006)1.70637286
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.70194584
136Orthostatic hypotension (HP:0001278)1.69960589
137Autoamputation (HP:0001218)1.68606930
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.68357716
139Abnormality of the ileum (HP:0001549)1.68010109
140Proximal placement of thumb (HP:0009623)1.67262313
141Abnormality of reticulocytes (HP:0004312)1.67057054
142Fasciculations (HP:0002380)1.64947051
143Abnormal number of incisors (HP:0011064)1.64658800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.77756818
2VRK24.32150186
3PDK34.31935976
4PDK44.31935976
5WEE13.32063504
6EIF2AK13.19665753
7TESK13.18801737
8TESK23.17878974
9PASK3.15615604
10PDK22.62697180
11NME22.42005402
12NEK12.12437286
13PBK2.02902061
14TSSK61.98535830
15CDC71.95713853
16STK391.92656559
17LIMK11.88979951
18NME11.84623784
19PNCK1.80404418
20EIF2AK31.74051091
21STK161.73427982
22BCKDK1.67572294
23SMG11.50266631
24PAK41.49960596
25MYLK1.49680367
26IRAK31.39282824
27TTN1.38887577
28CCNB11.35747617
29NEK21.33531655
30RPS6KB21.32219518
31TTK1.25720860
32CDK81.25665209
33VRK11.19199575
34MST41.18140809
35PLK41.14250678
36TLK11.10709857
37ILK1.09341449
38PLK11.09302699
39PAK11.08883949
40OBSCN1.06896547
41KDR1.05200868
42AURKA1.04270814
43MAP2K71.03442285
44ICK1.01398070
45EPHA20.98337716
46WNK40.95556805
47PTK2B0.94133610
48AURKB0.91203657
49OXSR10.89184681
50SRPK10.89082714
51BCR0.88964684
52BRSK10.79282797
53MST1R0.79204814
54PIM20.78872000
55DYRK30.77903326
56SCYL20.77830249
57BRSK20.77509062
58TAF10.75429432
59PLK30.74839775
60MAP3K80.73863592
61ROCK20.73561936
62DAPK30.71323638
63CSNK1A1L0.71005003
64STK100.69835637
65CDK140.68026491
66LRRK20.67886498
67MAPKAPK30.67056472
68MAP3K110.66422500
69NTRK10.65768661
70ATR0.63247812
71ERBB40.62908470
72CHEK10.62462550
73MKNK10.62368528
74CSNK1G10.60928988
75CDK150.60928935
76CDK180.60898712
77TGFBR10.59874058
78CSNK2A20.57785401
79LATS20.55527805
80TRIM280.55427913
81CSNK2A10.55294654
82CDK11A0.55250402
83CSNK1G30.54234122
84CDK190.53810935
85CSNK1G20.53706862
86DYRK20.52275456
87RPS6KA50.51289524
88EPHB20.50940557
89MAPKAPK50.50011412
90ARAF0.48281398
91TAOK20.48227477
92PAK20.48142562
93ALK0.47138635
94ABL20.46296262
95EIF2AK20.45917236
96MET0.45513736
97CHEK20.45291204
98CLK10.44961263
99MUSK0.44242625
100ACVR1B0.44091636
101STK40.43803859
102ATM0.43254311
103CDK70.42979575
104BRAF0.42940831
105UHMK10.42158486
106PRKCI0.40595708
107PKN20.40346648
108PAK60.38725085
109LMTK20.37767674
110PTK20.33786082
111ZAK0.33709738
112TRIB30.33037629
113CDK40.29767770
114RPS6KA40.25538454
115GRK60.23020517
116CDK20.22144464
117CSNK1E0.21736949
118EEF2K0.20019816
119PLK20.19444595
120AKT20.18213308
121MAP3K120.18199691
122CDK10.17975439
123CAMK2G0.17755366
124DAPK10.17171403
125CAMK2D0.15839594

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.10680924
2Ribosome_Homo sapiens_hsa030103.62594692
3Oxidative phosphorylation_Homo sapiens_hsa001903.44770260
4DNA replication_Homo sapiens_hsa030303.25409088
5Parkinsons disease_Homo sapiens_hsa050123.23610913
6RNA polymerase_Homo sapiens_hsa030202.79461928
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70043186
8Mismatch repair_Homo sapiens_hsa034302.56177337
9Huntingtons disease_Homo sapiens_hsa050162.53150933
10Spliceosome_Homo sapiens_hsa030402.51008534
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27772615
12RNA transport_Homo sapiens_hsa030132.13902200
13Alzheimers disease_Homo sapiens_hsa050102.12690480
14Pyruvate metabolism_Homo sapiens_hsa006202.11524253
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04001944
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01902705
17Pyrimidine metabolism_Homo sapiens_hsa002402.00751907
18Nucleotide excision repair_Homo sapiens_hsa034201.95001695
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85033535
20Base excision repair_Homo sapiens_hsa034101.82682440
21Carbon metabolism_Homo sapiens_hsa012001.82674773
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73851689
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72438074
24Homologous recombination_Homo sapiens_hsa034401.68755244
25Cardiac muscle contraction_Homo sapiens_hsa042601.66050759
26Biosynthesis of amino acids_Homo sapiens_hsa012301.61654930
27Basal transcription factors_Homo sapiens_hsa030221.61585887
28Propanoate metabolism_Homo sapiens_hsa006401.55660668
29Vitamin B6 metabolism_Homo sapiens_hsa007501.51906083
30Pentose phosphate pathway_Homo sapiens_hsa000301.49107822
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46929860
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.43738305
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42950339
34Fatty acid elongation_Homo sapiens_hsa000621.36988247
35Cell cycle_Homo sapiens_hsa041101.34281480
36Purine metabolism_Homo sapiens_hsa002301.23957402
37Glutathione metabolism_Homo sapiens_hsa004801.20204621
38Steroid biosynthesis_Homo sapiens_hsa001001.16619320
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11807033
40One carbon pool by folate_Homo sapiens_hsa006701.11567219
41Protein export_Homo sapiens_hsa030601.07058649
42Non-homologous end-joining_Homo sapiens_hsa034500.99494201
43RNA degradation_Homo sapiens_hsa030180.98720888
44N-Glycan biosynthesis_Homo sapiens_hsa005100.96807829
45Fructose and mannose metabolism_Homo sapiens_hsa000510.94131973
46Systemic lupus erythematosus_Homo sapiens_hsa053220.93413030
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87901466
48Fanconi anemia pathway_Homo sapiens_hsa034600.86742628
49Sulfur relay system_Homo sapiens_hsa041220.84349557
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.80885054
51* Epstein-Barr virus infection_Homo sapiens_hsa051690.78056166
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75039138
53Arginine and proline metabolism_Homo sapiens_hsa003300.74494836
54Metabolic pathways_Homo sapiens_hsa011000.73368272
55Oocyte meiosis_Homo sapiens_hsa041140.71477062
56Selenocompound metabolism_Homo sapiens_hsa004500.70773176
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68607144
58mRNA surveillance pathway_Homo sapiens_hsa030150.67781253
59Linoleic acid metabolism_Homo sapiens_hsa005910.66821443
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66517835
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63243535
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60370490
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59853452
64Collecting duct acid secretion_Homo sapiens_hsa049660.56818711
65p53 signaling pathway_Homo sapiens_hsa041150.55137690
66Folate biosynthesis_Homo sapiens_hsa007900.54801583
67Fatty acid degradation_Homo sapiens_hsa000710.54427106
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53169636
69Fatty acid metabolism_Homo sapiens_hsa012120.52129268
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50989635
71Arginine biosynthesis_Homo sapiens_hsa002200.50541355
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.48016070
73Viral carcinogenesis_Homo sapiens_hsa052030.42154011
74Arachidonic acid metabolism_Homo sapiens_hsa005900.42107763
75Bladder cancer_Homo sapiens_hsa052190.41506826
76Vibrio cholerae infection_Homo sapiens_hsa051100.41081354
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40594715
78Phenylalanine metabolism_Homo sapiens_hsa003600.35100020
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34958867
80Butanoate metabolism_Homo sapiens_hsa006500.34945079
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32656965
82Tight junction_Homo sapiens_hsa045300.31994341
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30554079
84Antigen processing and presentation_Homo sapiens_hsa046120.30364570
85Tyrosine metabolism_Homo sapiens_hsa003500.30066677
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28058901
87Thyroid cancer_Homo sapiens_hsa052160.27948822
88Alcoholism_Homo sapiens_hsa050340.27944830
89Ether lipid metabolism_Homo sapiens_hsa005650.25587827
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23053118
91Peroxisome_Homo sapiens_hsa041460.23034198
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21185321
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20931056
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20051452
95Fat digestion and absorption_Homo sapiens_hsa049750.19285381
96Sulfur metabolism_Homo sapiens_hsa009200.18534337
97Legionellosis_Homo sapiens_hsa051340.17870227
98Shigellosis_Homo sapiens_hsa051310.17618846
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16367419
100Renin-angiotensin system_Homo sapiens_hsa046140.16085634
101Synaptic vesicle cycle_Homo sapiens_hsa047210.15636691
102Prion diseases_Homo sapiens_hsa050200.13252244
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13138926
104beta-Alanine metabolism_Homo sapiens_hsa004100.13075569
105Phagosome_Homo sapiens_hsa041450.12335674
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.12070138
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11440645
108Apoptosis_Homo sapiens_hsa042100.10591117
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09731446
110HIF-1 signaling pathway_Homo sapiens_hsa040660.09706340
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09695036
112Basal cell carcinoma_Homo sapiens_hsa052170.07904774
113Chemical carcinogenesis_Homo sapiens_hsa052040.07325292
114Hippo signaling pathway_Homo sapiens_hsa043900.07117661
115Salmonella infection_Homo sapiens_hsa051320.06754320
116Galactose metabolism_Homo sapiens_hsa000520.06670192
117HTLV-I infection_Homo sapiens_hsa051660.05896155
118Hedgehog signaling pathway_Homo sapiens_hsa043400.05865513
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.04452313

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