PSMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.62627478
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27898638
3proteasome assembly (GO:0043248)5.25364568
4protein deneddylation (GO:0000338)5.13496866
5* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.06109796
6* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.84400598
7* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.68975763
8* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.67957288
9* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.66304973
10* negative regulation of ligase activity (GO:0051352)4.66304973
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60907333
12ATP synthesis coupled proton transport (GO:0015986)4.60907333
13* regulation of cellular amino acid metabolic process (GO:0006521)4.56427006
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.50562261
15nucleobase biosynthetic process (GO:0046112)4.49678780
16purine nucleobase biosynthetic process (GO:0009113)4.48859396
17ribosomal small subunit biogenesis (GO:0042274)4.39173139
18* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.37118746
19formation of translation preinitiation complex (GO:0001731)4.34810299
20* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.27978700
21* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.27978700
22* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.27194582
23viral transcription (GO:0019083)4.25887039
24protein neddylation (GO:0045116)4.25820416
25* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.24276402
26* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.24276402
27* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.24276402
28* signal transduction involved in DNA damage checkpoint (GO:0072422)4.23815484
29* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.23815484
30ribosomal small subunit assembly (GO:0000028)4.21281844
31translational termination (GO:0006415)4.21075920
32* signal transduction involved in cell cycle checkpoint (GO:0072395)4.19880589
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17198390
34CENP-A containing nucleosome assembly (GO:0034080)4.15688359
35cotranslational protein targeting to membrane (GO:0006613)4.14368158
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.13886169
37protein targeting to ER (GO:0045047)4.10881302
38* positive regulation of ligase activity (GO:0051351)4.03380680
39chromatin remodeling at centromere (GO:0031055)4.00896543
40ribosome assembly (GO:0042255)3.99926298
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95988084
42termination of RNA polymerase III transcription (GO:0006386)3.93320611
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.93320611
447-methylguanosine mRNA capping (GO:0006370)3.91341233
45protein localization to endoplasmic reticulum (GO:0070972)3.88670997
46translation (GO:0006412)3.82410389
47RNA capping (GO:0036260)3.80493080
487-methylguanosine RNA capping (GO:0009452)3.80493080
49* regulation of ubiquitin-protein transferase activity (GO:0051438)3.80437632
50L-methionine salvage (GO:0071267)3.76478477
51L-methionine biosynthetic process (GO:0071265)3.76478477
52amino acid salvage (GO:0043102)3.76478477
53translational initiation (GO:0006413)3.75412871
54chaperone-mediated protein transport (GO:0072321)3.75207680
55translational elongation (GO:0006414)3.74702494
56* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.73040481
57inner mitochondrial membrane organization (GO:0007007)3.68619277
58maturation of SSU-rRNA (GO:0030490)3.66062141
59regulation of mitochondrial translation (GO:0070129)3.63845376
60spliceosomal snRNP assembly (GO:0000387)3.63613159
61* regulation of ligase activity (GO:0051340)3.62479037
62mitotic metaphase plate congression (GO:0007080)3.58422274
63rRNA modification (GO:0000154)3.55438961
64DNA strand elongation involved in DNA replication (GO:0006271)3.54553956
65ribosome biogenesis (GO:0042254)3.52389591
66establishment of integrated proviral latency (GO:0075713)3.50062332
67viral life cycle (GO:0019058)3.50034881
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48540186
69transcription elongation from RNA polymerase I promoter (GO:0006362)3.47765250
70* positive regulation of cell cycle arrest (GO:0071158)3.47235757
71* regulation of cellular amine metabolic process (GO:0033238)3.41969090
72* G1/S transition of mitotic cell cycle (GO:0000082)3.38853295
73* cell cycle G1/S phase transition (GO:0044843)3.38853295
74* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.37469292
75nucleobase-containing small molecule interconversion (GO:0015949)3.36213436
76establishment of protein localization to mitochondrion (GO:0072655)3.34434357
77spliceosomal complex assembly (GO:0000245)3.33666451
78protein complex biogenesis (GO:0070271)3.31798208
79de novo protein folding (GO:0006458)3.31699081
80mitochondrial respiratory chain complex assembly (GO:0033108)3.31264942
81cellular protein complex disassembly (GO:0043624)3.30360711
82DNA strand elongation (GO:0022616)3.29916174
83termination of RNA polymerase I transcription (GO:0006363)3.29131701
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28836139
85ribosomal large subunit biogenesis (GO:0042273)3.28173451
86maturation of 5.8S rRNA (GO:0000460)3.27847717
87DNA unwinding involved in DNA replication (GO:0006268)3.27179067
88* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.27150871
89DNA replication initiation (GO:0006270)3.25693348
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25106210
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.25106210
92NADH dehydrogenase complex assembly (GO:0010257)3.25106210
93DNA damage response, detection of DNA damage (GO:0042769)3.24789536
94transcription from RNA polymerase I promoter (GO:0006360)3.24339232
95histone exchange (GO:0043486)3.24237235
96tRNA aminoacylation for protein translation (GO:0006418)3.23581360
97ribonucleoprotein complex biogenesis (GO:0022613)3.22020027
98de novo posttranslational protein folding (GO:0051084)3.20922959
99protein targeting to mitochondrion (GO:0006626)3.19978355
100DNA replication checkpoint (GO:0000076)3.19521271
101tRNA aminoacylation (GO:0043039)3.17535228
102amino acid activation (GO:0043038)3.17535228
103transcription-coupled nucleotide-excision repair (GO:0006283)3.17182694
104* negative regulation of protein ubiquitination (GO:0031397)3.14965979
105protein localization to mitochondrion (GO:0070585)3.13274678
106IMP biosynthetic process (GO:0006188)3.13192421
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12646135
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12646135
109rRNA processing (GO:0006364)3.11348824
110DNA ligation (GO:0006266)3.11236033
111viral mRNA export from host cell nucleus (GO:0046784)3.11100434
112transcription initiation from RNA polymerase I promoter (GO:0006361)3.09422481
113respiratory electron transport chain (GO:0022904)3.06591683
114protein-cofactor linkage (GO:0018065)3.05100476
115DNA replication-dependent nucleosome organization (GO:0034723)3.04908712
116DNA replication-dependent nucleosome assembly (GO:0006335)3.04908712
117telomere maintenance via semi-conservative replication (GO:0032201)3.03399003
118establishment of viral latency (GO:0019043)3.03183994
119* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.02353865
120* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.02093305
121* negative regulation of cell cycle G1/S phase transition (GO:1902807)3.02093305
122oxidative phosphorylation (GO:0006119)3.01905564
123protein localization to kinetochore (GO:0034501)3.00531059
124chaperone-mediated protein complex assembly (GO:0051131)3.00450889
125metaphase plate congression (GO:0051310)2.99141719
126cellular component biogenesis (GO:0044085)2.98461358
127electron transport chain (GO:0022900)2.98293732
128methionine biosynthetic process (GO:0009086)2.97870585
129rRNA metabolic process (GO:0016072)2.96110360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.01700074
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79152495
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30738060
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.20608805
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.95673299
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93139181
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87074372
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.81377467
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.79027881
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75129414
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18358205
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.09284649
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05719619
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05338105
15MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01673059
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96565524
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84110542
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.71992814
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69354421
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54382692
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48951254
22XRN2_22483619_ChIP-Seq_HELA_Human2.48343538
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42347231
24VDR_23849224_ChIP-Seq_CD4+_Human2.40897599
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39024710
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36534987
27DCP1A_22483619_ChIP-Seq_HELA_Human2.35444614
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32770564
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30648051
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.29251920
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.27789757
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15116536
33* GABP_19822575_ChIP-Seq_HepG2_Human2.11721871
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04582461
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.04167335
36* FOXP3_21729870_ChIP-Seq_TREG_Human2.03318490
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01766824
38ELK1_19687146_ChIP-ChIP_HELA_Human1.98355655
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93932797
40TTF2_22483619_ChIP-Seq_HELA_Human1.93468617
41AR_21909140_ChIP-Seq_LNCAP_Human1.90084426
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87746196
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81378898
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76200393
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75808105
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57356901
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53868505
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51304821
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51211507
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50933760
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49666257
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47588429
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45493741
54KDM5A_27292631_Chip-Seq_BREAST_Human1.41374787
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37345012
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32398882
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28780411
58* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21437061
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.21376737
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.20461260
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19856419
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19820670
63MYC_18940864_ChIP-ChIP_HL60_Human1.19545927
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19373698
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19114505
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18255941
67* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17038492
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.16064544
69CIITA_25753668_ChIP-Seq_RAJI_Human1.16053172
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15959108
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15350050
72ZNF263_19887448_ChIP-Seq_K562_Human1.14378276
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08474665
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08244724
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05127681
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04207406
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00685318
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99663172
79SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99346348
80* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99083011
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.96997414
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96248671
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96182688
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95682425
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95249067
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94384892
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93131136
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92911142
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92828375
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.91505750
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91263181
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89486535
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89227461
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88772485
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88344338
96TFEB_21752829_ChIP-Seq_HELA_Human0.87461535
97ELF5_23300383_ChIP-Seq_T47D_Human0.86230221
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85760896
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85272907
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84451438
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83491200
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82601649
103IRF1_19129219_ChIP-ChIP_H3396_Human0.82108180
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82000942
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81627165
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81525836
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80559957
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80108826
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79366198
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77426459
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77115344
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.76075035
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.75494668
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75446196
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75369343
116NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74946716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.48688106
2MP0004957_abnormal_blastocyst_morpholog4.30941379
3MP0003806_abnormal_nucleotide_metabolis4.15962124
4MP0009379_abnormal_foot_pigmentation3.92505840
5MP0003111_abnormal_nucleus_morphology3.29280633
6MP0010094_abnormal_chromosome_stability3.26297788
7MP0008932_abnormal_embryonic_tissue3.24921613
8MP0003123_paternal_imprinting3.01590289
9MP0003077_abnormal_cell_cycle2.97167623
10MP0003718_maternal_effect2.83631011
11MP0001529_abnormal_vocalization2.77392362
12MP0008057_abnormal_DNA_replication2.39458731
13MP0001730_embryonic_growth_arrest2.28999792
14MP0003941_abnormal_skin_development2.21990761
15MP0008058_abnormal_DNA_repair2.20157295
16MP0006035_abnormal_mitochondrial_morpho2.15671306
17MP0008877_abnormal_DNA_methylation2.01995431
18MP0008260_abnormal_autophagy1.99393412
19MP0006036_abnormal_mitochondrial_physio1.95106013
20MP0006292_abnormal_olfactory_placode1.95035379
21MP0003786_premature_aging1.87582976
22MP0003315_abnormal_perineum_morphology1.73890639
23MP0008007_abnormal_cellular_replicative1.59626393
24MP0003880_abnormal_central_pattern1.58381257
25MP0003186_abnormal_redox_activity1.57857777
26MP0002653_abnormal_ependyma_morphology1.56424483
27MP0003122_maternal_imprinting1.55069966
28MP0003121_genomic_imprinting1.52158548
29MP0001853_heart_inflammation1.51901626
30MP0003221_abnormal_cardiomyocyte_apopto1.51216043
31MP0000350_abnormal_cell_proliferation1.50732318
32MP0005084_abnormal_gallbladder_morpholo1.48533679
33MP0001727_abnormal_embryo_implantation1.48313915
34MP0002736_abnormal_nociception_after1.42900805
35MP0001697_abnormal_embryo_size1.42242987
36MP0000537_abnormal_urethra_morphology1.41512968
37MP0004270_analgesia1.38753115
38MP0005408_hypopigmentation1.36937102
39MP0000358_abnormal_cell_content/1.36344471
40MP0002837_dystrophic_cardiac_calcinosis1.34620773
41MP0001672_abnormal_embryogenesis/_devel1.32779497
42MP0005380_embryogenesis_phenotype1.32779497
43MP0004084_abnormal_cardiac_muscle1.32358557
44MP0002160_abnormal_reproductive_system1.31956195
45* MP0002080_prenatal_lethality1.30574207
46* MP0001905_abnormal_dopamine_level1.30150934
47MP0002277_abnormal_respiratory_mucosa1.29483681
48MP0006072_abnormal_retinal_apoptosis1.27970012
49MP0003011_delayed_dark_adaptation1.27871331
50MP0001542_abnormal_bone_strength1.27589180
51MP0009697_abnormal_copulation1.26958352
52MP0002751_abnormal_autonomic_nervous1.26631454
53MP0001881_abnormal_mammary_gland1.25823037
54MP0002102_abnormal_ear_morphology1.21761425
55MP0002877_abnormal_melanocyte_morpholog1.21432812
56MP0003984_embryonic_growth_retardation1.15772208
57MP0002735_abnormal_chemical_nociception1.12946040
58MP0006276_abnormal_autonomic_nervous1.12917460
59MP0002085_abnormal_embryonic_tissue1.12708210
60MP0000372_irregular_coat_pigmentation1.11676469
61MP0002088_abnormal_embryonic_growth/wei1.10930582
62MP0003890_abnormal_embryonic-extraembry1.09740571
63MP0001346_abnormal_lacrimal_gland1.09682488
64MP0002734_abnormal_mechanical_nocicepti1.04038610
65MP0002269_muscular_atrophy1.04001865
66MP0004036_abnormal_muscle_relaxation1.03679996
67MP0005266_abnormal_metabolism1.03495795
68MP0009046_muscle_twitch1.03300527
69MP0000647_abnormal_sebaceous_gland1.01453086
70MP0000749_muscle_degeneration1.01144953
71MP0004142_abnormal_muscle_tone0.99526901
72MP0001968_abnormal_touch/_nociception0.99100653
73MP0000343_altered_response_to0.98700694
74MP0004133_heterotaxia0.98651171
75MP0002084_abnormal_developmental_patter0.97921443
76MP0002090_abnormal_vision0.97821891
77MP0000750_abnormal_muscle_regeneration0.97282221
78MP0002697_abnormal_eye_size0.97254450
79MP0005171_absent_coat_pigmentation0.96948351
80MP0000751_myopathy0.96690051
81MP0000747_muscle_weakness0.95608492
82MP0003950_abnormal_plasma_membrane0.95576990
83MP0008875_abnormal_xenobiotic_pharmacok0.93326014
84MP0010030_abnormal_orbit_morphology0.90203223
85MP0004147_increased_porphyrin_level0.89516289
86MP0005501_abnormal_skin_physiology0.88482858
87MP0010307_abnormal_tumor_latency0.88187692
88MP0003567_abnormal_fetal_cardiomyocyte0.87829159
89MP0001286_abnormal_eye_development0.87632658
90MP0003646_muscle_fatigue0.86861976
91MP0005389_reproductive_system_phenotype0.85396109
92MP0001485_abnormal_pinna_reflex0.85296132
93MP0009053_abnormal_anal_canal0.85062280
94MP0002210_abnormal_sex_determination0.84912068
95MP0001440_abnormal_grooming_behavior0.84742808
96MP0009672_abnormal_birth_weight0.84725571
97MP0008789_abnormal_olfactory_epithelium0.84686576
98MP0004145_abnormal_muscle_electrophysio0.84076819
99MP0003119_abnormal_digestive_system0.83368035
100MP0004197_abnormal_fetal_growth/weight/0.82904132
101MP0005197_abnormal_uvea_morphology0.82541883
102MP0000313_abnormal_cell_death0.81621345
103MP0005058_abnormal_lysosome_morphology0.79920691
104MP0001764_abnormal_homeostasis0.79709167
105MP0004233_abnormal_muscle_weight0.77652818
106MP0002272_abnormal_nervous_system0.77546334
107MP0000579_abnormal_nail_morphology0.75359862
108MP0002064_seizures0.75174975
109MP0003136_yellow_coat_color0.75112971
110MP0003937_abnormal_limbs/digits/tail_de0.73794173
111MP0000762_abnormal_tongue_morphology0.72488905
112MP0000627_abnormal_mammary_gland0.72338875
113MP0001145_abnormal_male_reproductive0.71910815
114MP0003329_amyloid_beta_deposits0.71011002
115MP0005395_other_phenotype0.70115325
116MP0005330_cardiomyopathy0.69035630
117MP0001929_abnormal_gametogenesis0.68899290
118MP0005623_abnormal_meninges_morphology0.68819609
119MP0005384_cellular_phenotype0.68736214
120MP0000490_abnormal_crypts_of0.68335209
121MP0005376_homeostasis/metabolism_phenot0.66968287
122MP0005410_abnormal_fertilization0.66901472
123MP0005193_abnormal_anterior_eye0.66664442
124MP0004215_abnormal_myocardial_fiber0.66463105
125MP0003861_abnormal_nervous_system0.66171172
126MP0001293_anophthalmia0.66071436
127MP0002938_white_spotting0.65989885
128MP0002127_abnormal_cardiovascular_syste0.65417095
129MP0002095_abnormal_skin_pigmentation0.65246672
130MP0003656_abnormal_erythrocyte_physiolo0.64465870
131MP0002111_abnormal_tail_morphology0.64433379
132MP0005386_behavior/neurological_phenoty0.63688507
133MP0004924_abnormal_behavior0.63688507
134MP0002163_abnormal_gland_morphology0.63583864
135MP0005391_vision/eye_phenotype0.63303063
136MP0002019_abnormal_tumor_incidence0.61472708
137MP0002092_abnormal_eye_morphology0.61371306
138MP0002796_impaired_skin_barrier0.59593622

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)6.02343070
2Increased serum pyruvate (HP:0003542)6.02343070
3Cerebral hypomyelination (HP:0006808)4.93995268
4Acute necrotizing encephalopathy (HP:0006965)4.69379544
5Abnormal mitochondria in muscle tissue (HP:0008316)4.35751507
6Renal Fanconi syndrome (HP:0001994)4.19249640
7Mitochondrial inheritance (HP:0001427)4.04207646
8Increased CSF lactate (HP:0002490)3.97495865
9Hepatocellular necrosis (HP:0001404)3.92764797
10Acute encephalopathy (HP:0006846)3.87780484
11Increased intramyocellular lipid droplets (HP:0012240)3.73272917
12Progressive macrocephaly (HP:0004481)3.70693371
13Birth length less than 3rd percentile (HP:0003561)3.52507100
14Abnormal number of erythroid precursors (HP:0012131)3.39056114
15Hepatic necrosis (HP:0002605)3.30750898
16Abnormality of the labia minora (HP:0012880)3.26534739
17Breast hypoplasia (HP:0003187)3.20116280
18Increased serum lactate (HP:0002151)3.18761405
19Carpal bone hypoplasia (HP:0001498)3.11182451
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09688152
21Abnormality of alanine metabolism (HP:0010916)3.09688152
22Hyperalaninemia (HP:0003348)3.09688152
23Degeneration of anterior horn cells (HP:0002398)3.09007636
24Abnormality of the anterior horn cell (HP:0006802)3.09007636
25Increased muscle lipid content (HP:0009058)3.06930582
26Type I transferrin isoform profile (HP:0003642)3.00081656
27CNS demyelination (HP:0007305)2.90058588
28CNS hypomyelination (HP:0003429)2.89958438
29Respiratory failure (HP:0002878)2.86772567
30Delusions (HP:0000746)2.86074877
31Cerebral edema (HP:0002181)2.83792697
32Leukodystrophy (HP:0002415)2.83506632
33Aplastic anemia (HP:0001915)2.77173917
34Exertional dyspnea (HP:0002875)2.74938848
35Lactic acidosis (HP:0003128)2.72063984
36Emotional lability (HP:0000712)2.68264955
373-Methylglutaconic aciduria (HP:0003535)2.67805279
38Postnatal microcephaly (HP:0005484)2.67659876
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59124418
40Respiratory difficulties (HP:0002880)2.58472488
41Reduced antithrombin III activity (HP:0001976)2.57071189
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.56512472
43Generalized aminoaciduria (HP:0002909)2.54502684
44Exercise intolerance (HP:0003546)2.53496739
45Autoamputation (HP:0001218)2.53291730
46Sparse eyelashes (HP:0000653)2.52669546
47Rough bone trabeculation (HP:0100670)2.48246468
48Abnormality of renal resorption (HP:0011038)2.44111858
49Oral leukoplakia (HP:0002745)2.41593716
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41537377
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39992730
52Abnormal glycosylation (HP:0012345)2.38834359
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38834359
54Abnormal protein N-linked glycosylation (HP:0012347)2.38834359
55Abnormal protein glycosylation (HP:0012346)2.38834359
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36110265
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36110265
58Abnormality of methionine metabolism (HP:0010901)2.35725341
59Congenital, generalized hypertrichosis (HP:0004540)2.34933320
60Neuroendocrine neoplasm (HP:0100634)2.31754845
61Pheochromocytoma (HP:0002666)2.31568038
62Increased hepatocellular lipid droplets (HP:0006565)2.31314762
63Pancytopenia (HP:0001876)2.30423814
64Aplasia/Hypoplasia of the patella (HP:0006498)2.30088555
65Trismus (HP:0000211)2.28853412
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28037322
67Patellar aplasia (HP:0006443)2.27300653
68Multiple enchondromatosis (HP:0005701)2.23858031
69Atrophy/Degeneration involving motor neurons (HP:0007373)2.21752299
70Unsteady gait (HP:0002317)2.21492699
71Secondary amenorrhea (HP:0000869)2.19242733
72Progressive external ophthalmoplegia (HP:0000590)2.18945410
73Abnormality of the preputium (HP:0100587)2.15635880
74Pallor (HP:0000980)2.14270968
75Meckel diverticulum (HP:0002245)2.13765524
76Lipid accumulation in hepatocytes (HP:0006561)2.12303136
77Shoulder girdle muscle weakness (HP:0003547)2.12106113
78Absent radius (HP:0003974)2.10216930
79Hypobetalipoproteinemia (HP:0003563)2.10153743
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09184305
81Progressive muscle weakness (HP:0003323)2.06763948
82Microretrognathia (HP:0000308)2.04904667
83Premature ovarian failure (HP:0008209)2.03790523
84Abnormality of the umbilical cord (HP:0010881)2.02694708
85Tongue fasciculations (HP:0001308)2.00795894
86Stenosis of the external auditory canal (HP:0000402)2.00767266
87Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97775151
88Horseshoe kidney (HP:0000085)1.97385152
89Absent forearm bone (HP:0003953)1.97131751
90Aplasia involving forearm bones (HP:0009822)1.97131751
91Optic disc pallor (HP:0000543)1.96721082
92Lethargy (HP:0001254)1.96647089
93Muscle fiber inclusion bodies (HP:0100299)1.95155635
94Irregular epiphyses (HP:0010582)1.95113114
95Limb-girdle muscle atrophy (HP:0003797)1.94033596
96Spastic paraparesis (HP:0002313)1.92813915
97Abnormality of the ileum (HP:0001549)1.92742297
98Amniotic constriction ring (HP:0009775)1.91556337
99Abnormality of placental membranes (HP:0011409)1.91556337
100Rimmed vacuoles (HP:0003805)1.90622912
101Poor suck (HP:0002033)1.90204802
102Macrocytic anemia (HP:0001972)1.89448417
103Muscle fibrillation (HP:0010546)1.89197088
104Megaloblastic anemia (HP:0001889)1.88868105
105Abnormality of cells of the erythroid lineage (HP:0012130)1.88045260
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87877278
107Long foot (HP:0001833)1.87248627
108Congenital ichthyosiform erythroderma (HP:0007431)1.86905857
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85076542
110Absent epiphyses (HP:0010577)1.85076542
111Abnormal hair whorl (HP:0010721)1.84185613
112Nemaline bodies (HP:0003798)1.83798012
113Nausea (HP:0002018)1.83777887
114Abnormalities of placenta or umbilical cord (HP:0001194)1.81953050
115Abnormality of urine glucose concentration (HP:0011016)1.80036988
116Glycosuria (HP:0003076)1.80036988
117Reticulocytopenia (HP:0001896)1.79739840
118Abnormal trabecular bone morphology (HP:0100671)1.79489288
119Ragged-red muscle fibers (HP:0003200)1.78334329
120Neoplasm of the adrenal gland (HP:0100631)1.76994492
121Absent thumb (HP:0009777)1.76959817
122X-linked dominant inheritance (HP:0001423)1.76410493
123Chromsome breakage (HP:0040012)1.76372890
124Methylmalonic acidemia (HP:0002912)1.75612050
125Abnormality of serum amino acid levels (HP:0003112)1.74987661
126External ophthalmoplegia (HP:0000544)1.74781494
127Microvesicular hepatic steatosis (HP:0001414)1.73717571
128Hypokinesia (HP:0002375)1.73147254
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.71945399
130Death in infancy (HP:0001522)1.71590385
131Hyperglycinemia (HP:0002154)1.70867104
132Glossoptosis (HP:0000162)1.70076817
133Blindness (HP:0000618)1.69941883
134Abnormal umbilical cord blood vessels (HP:0011403)1.69179202
135Single umbilical artery (HP:0001195)1.69179202
136Abnormality of the fetal cardiovascular system (HP:0010948)1.69179202
137Hyperphosphaturia (HP:0003109)1.67328111
138Duodenal stenosis (HP:0100867)1.66776299
139Small intestinal stenosis (HP:0012848)1.66776299
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66533844
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65652151
142Abnormality of chromosome stability (HP:0003220)1.64799245
143Abnormal autonomic nervous system physiology (HP:0012332)1.62949037
144Gliosis (HP:0002171)1.61602127
145Abnormal lung lobation (HP:0002101)1.61323517
146Selective tooth agenesis (HP:0001592)1.60629753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.12910731
2VRK24.14190127
3TSSK63.90760727
4EIF2AK13.68316820
5WEE13.37738099
6STK163.29116732
7NEK12.45365487
8PNCK2.22511657
9NME12.20113023
10LIMK12.18622074
11CDC72.09349538
12TESK22.01712993
13SRPK11.97263315
14PLK31.86930837
15EIF2AK31.81160741
16EPHA21.78477234
17AKT31.72859869
18MAP3K121.66061793
19CASK1.65994538
20PBK1.64135535
21BRSK21.61487021
22PDK31.59644467
23PDK41.59644467
24MKNK11.59109095
25CCNB11.57009961
26PLK41.54794609
27BRAF1.47776634
28PLK21.41648827
29BCR1.41571122
30TTK1.40987402
31BRSK11.39839734
32AURKA1.37865752
33ACVR1B1.36387918
34TRIM281.34195288
35PLK11.32908198
36CDK191.30748622
37MST41.30260350
38TESK11.29745202
39ARAF1.23661084
40PDK21.22692778
41VRK11.19976200
42OXSR11.04054419
43TAF11.03714639
44IRAK30.97780806
45BCKDK0.96951412
46DYRK20.94064918
47MKNK20.92373646
48NME20.88216990
49AURKB0.86913295
50DAPK10.85023460
51MYLK0.82112538
52TLK10.81775377
53PAK10.81283744
54STK390.78532574
55RPS6KB20.77436714
56ILK0.77028758
57INSRR0.75511968
58PAK40.74521856
59CDK140.74193914
60PASK0.73965571
61PRPF4B0.73536686
62ZAK0.72036812
63CDK180.71751340
64MARK10.70503832
65PRKCI0.70133087
66STK38L0.68564766
67NEK20.68245408
68CHEK10.67234566
69RPS6KA40.66828063
70CDK150.65535459
71CSNK2A20.65354317
72LRRK20.65345388
73NUAK10.64055446
74CSNK2A10.63035928
75KDR0.62314049
76ERBB30.61375150
77CHEK20.60939455
78PHKG20.59973884
79PHKG10.59973884
80ATR0.59807942
81CDK11A0.59457988
82OBSCN0.58141406
83CSNK1G30.57812468
84CAMK2B0.57166727
85PIM20.53917861
86CDK80.53721398
87SCYL20.53126105
88MAP3K80.52904714
89ROCK20.52716265
90MAP2K70.52094221
91ERBB40.52026723
92MET0.51952691
93CSNK1G10.51275359
94ALK0.50012312
95CSNK1E0.49217913
96PRKCG0.49153633
97MINK10.48301793
98BMPR1B0.48056568
99CDK70.47712518
100DAPK30.47452803
101MST1R0.47079502
102LATS20.46935209
103STK100.46651110
104TGFBR10.44514516
105MAP3K40.44162962
106CSNK1G20.44074796
107DYRK30.43448508
108GRK50.43086164
109CDK10.41576761
110CDK20.40655632
111MAPKAPK30.39868666
112AKT20.39021234
113STK40.38694864
114WNK30.38094867
115CAMK2G0.37439385
116ABL20.35929872
117MAP3K110.35653651
118SIK30.34966119
119ATM0.33817399
120UHMK10.33472271
121RPS6KA50.33392822
122CSNK1A1L0.31901974
123EIF2AK20.28122928

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.63242569
2RNA polymerase_Homo sapiens_hsa030203.58914246
3Oxidative phosphorylation_Homo sapiens_hsa001903.22340747
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11043420
5DNA replication_Homo sapiens_hsa030302.99730186
6Parkinsons disease_Homo sapiens_hsa050122.81491207
7Ribosome_Homo sapiens_hsa030102.78504917
8Mismatch repair_Homo sapiens_hsa034302.72294382
9Spliceosome_Homo sapiens_hsa030402.65983531
10RNA transport_Homo sapiens_hsa030132.60068775
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58339328
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53982463
13Nucleotide excision repair_Homo sapiens_hsa034202.17977638
14Huntingtons disease_Homo sapiens_hsa050162.16957947
15Pyrimidine metabolism_Homo sapiens_hsa002402.08439894
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06328857
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87069883
18Alzheimers disease_Homo sapiens_hsa050101.79080732
19Vitamin B6 metabolism_Homo sapiens_hsa007501.68417775
20Homologous recombination_Homo sapiens_hsa034401.64389692
21Base excision repair_Homo sapiens_hsa034101.63706567
22Cell cycle_Homo sapiens_hsa041101.60524251
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57101131
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55408593
25One carbon pool by folate_Homo sapiens_hsa006701.54357673
26Basal transcription factors_Homo sapiens_hsa030221.53357238
27Collecting duct acid secretion_Homo sapiens_hsa049661.49595873
28Carbon metabolism_Homo sapiens_hsa012001.42307383
29Biosynthesis of amino acids_Homo sapiens_hsa012301.37605473
30Pyruvate metabolism_Homo sapiens_hsa006201.36080143
31Protein export_Homo sapiens_hsa030601.34170968
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32005469
33Purine metabolism_Homo sapiens_hsa002301.22629624
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18448047
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17209388
36Fatty acid elongation_Homo sapiens_hsa000621.16767004
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16159594
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14322032
39RNA degradation_Homo sapiens_hsa030181.11306372
40Vibrio cholerae infection_Homo sapiens_hsa051101.08252508
41Steroid biosynthesis_Homo sapiens_hsa001000.98142248
42Non-homologous end-joining_Homo sapiens_hsa034500.97206890
43mRNA surveillance pathway_Homo sapiens_hsa030150.95088014
44Glutathione metabolism_Homo sapiens_hsa004800.93171763
45Oocyte meiosis_Homo sapiens_hsa041140.93010207
46* Epstein-Barr virus infection_Homo sapiens_hsa051690.92649010
47Pentose phosphate pathway_Homo sapiens_hsa000300.90023778
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89632935
49Cardiac muscle contraction_Homo sapiens_hsa042600.87396944
50Synaptic vesicle cycle_Homo sapiens_hsa047210.87254074
51Fanconi anemia pathway_Homo sapiens_hsa034600.85281706
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75903796
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73646267
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71918188
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70169222
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.69667289
57Folate biosynthesis_Homo sapiens_hsa007900.69660944
58Fructose and mannose metabolism_Homo sapiens_hsa000510.68879400
59Metabolic pathways_Homo sapiens_hsa011000.68150146
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.66385387
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65702999
62Propanoate metabolism_Homo sapiens_hsa006400.65258783
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65191861
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64041170
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63440352
66Regulation of autophagy_Homo sapiens_hsa041400.63175919
67Phenylalanine metabolism_Homo sapiens_hsa003600.62874488
68N-Glycan biosynthesis_Homo sapiens_hsa005100.61046146
69Tyrosine metabolism_Homo sapiens_hsa003500.58329809
70Arginine and proline metabolism_Homo sapiens_hsa003300.57823797
71Tryptophan metabolism_Homo sapiens_hsa003800.55863088
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49813411
73Selenocompound metabolism_Homo sapiens_hsa004500.49377598
74Butanoate metabolism_Homo sapiens_hsa006500.48297403
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46426199
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42439463
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41636376
78Fatty acid degradation_Homo sapiens_hsa000710.40748077
79Phagosome_Homo sapiens_hsa041450.39859188
80p53 signaling pathway_Homo sapiens_hsa041150.38517112
81Systemic lupus erythematosus_Homo sapiens_hsa053220.36190958
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35959490
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28781436
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27925931
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.27011141
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26964448
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23608936
88Shigellosis_Homo sapiens_hsa051310.22925859
89Sulfur relay system_Homo sapiens_hsa041220.22395996
90Rheumatoid arthritis_Homo sapiens_hsa053230.19923651
91Alcoholism_Homo sapiens_hsa050340.19091771
92Nicotine addiction_Homo sapiens_hsa050330.19018101
93Tight junction_Homo sapiens_hsa045300.18897625
94beta-Alanine metabolism_Homo sapiens_hsa004100.17509856
95Chemical carcinogenesis_Homo sapiens_hsa052040.16865040
96* Viral carcinogenesis_Homo sapiens_hsa052030.16210796
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13416430
98Peroxisome_Homo sapiens_hsa041460.12044548
99Lysosome_Homo sapiens_hsa041420.11659686
100TGF-beta signaling pathway_Homo sapiens_hsa043500.11290517
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11265312
102Hippo signaling pathway_Homo sapiens_hsa043900.10521116
103Arachidonic acid metabolism_Homo sapiens_hsa005900.10097213
104Fatty acid metabolism_Homo sapiens_hsa012120.09024258
105Renin-angiotensin system_Homo sapiens_hsa046140.06093355
106Galactose metabolism_Homo sapiens_hsa000520.05706068
107Caffeine metabolism_Homo sapiens_hsa002320.05352305
108Thyroid cancer_Homo sapiens_hsa052160.05341312
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05286708
110Bladder cancer_Homo sapiens_hsa052190.02428819
111Nitrogen metabolism_Homo sapiens_hsa009100.02332619
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.01912800
113Legionellosis_Homo sapiens_hsa051340.01328900
114Histidine metabolism_Homo sapiens_hsa003400.00864618
115Sulfur metabolism_Homo sapiens_hsa00920-0.0165195

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »