PSMB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)6.71642673
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.71642673
3proteasome assembly (GO:0043248)6.40896941
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.25376391
5ribosomal small subunit biogenesis (GO:0042274)6.15331423
6ribosomal large subunit biogenesis (GO:0042273)6.02627790
7viral transcription (GO:0019083)5.81959625
8ribosomal small subunit assembly (GO:0000028)5.77335730
9translational termination (GO:0006415)5.67598877
10maturation of SSU-rRNA (GO:0030490)5.33175211
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.18838116
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.07763592
13cotranslational protein targeting to membrane (GO:0006613)5.06416978
14protein targeting to ER (GO:0045047)5.01847288
15translational elongation (GO:0006414)4.97798520
16* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.96564103
17protein localization to endoplasmic reticulum (GO:0070972)4.78210247
18protein neddylation (GO:0045116)4.77591668
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.76231700
20respiratory electron transport chain (GO:0022904)4.62857719
21translational initiation (GO:0006413)4.62683762
22translation (GO:0006412)4.52891471
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.52761269
24* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.52252743
25* negative regulation of ligase activity (GO:0051352)4.52252743
26cellular protein complex disassembly (GO:0043624)4.52141607
27* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.51542613
28electron transport chain (GO:0022900)4.50195961
29viral life cycle (GO:0019058)4.47109256
30* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.43426602
31* regulation of cellular amino acid metabolic process (GO:0006521)4.39634950
32termination of RNA polymerase III transcription (GO:0006386)4.35983288
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.35983288
34* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.35420269
35ribonucleoprotein complex biogenesis (GO:0022613)4.33714365
36cullin deneddylation (GO:0010388)4.32868627
37regulation of mitochondrial translation (GO:0070129)4.30050154
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.26076272
39respiratory chain complex IV assembly (GO:0008535)4.21969984
40* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.16932688
41* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.16834913
42GTP biosynthetic process (GO:0006183)4.12285941
43* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.07193897
44* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.07193897
45chaperone-mediated protein transport (GO:0072321)4.05319783
46* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.04605199
47* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.04605199
48* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.04605199
49* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.02165746
50* signal transduction involved in DNA damage checkpoint (GO:0072422)4.02165746
51cytochrome complex assembly (GO:0017004)4.01394009
52protein deneddylation (GO:0000338)3.99431348
53* signal transduction involved in cell cycle checkpoint (GO:0072395)3.97321648
54* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.96160865
55* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.94892547
56cellular component biogenesis (GO:0044085)3.94209894
577-methylguanosine mRNA capping (GO:0006370)3.91710431
58protein complex biogenesis (GO:0070271)3.90658047
59protein complex disassembly (GO:0043241)3.86612351
60RNA capping (GO:0036260)3.84888377
617-methylguanosine RNA capping (GO:0009452)3.84888377
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84682795
63DNA deamination (GO:0045006)3.83075287
64* positive regulation of ligase activity (GO:0051351)3.81381170
65rRNA processing (GO:0006364)3.77153437
66UTP biosynthetic process (GO:0006228)3.73383465
67macromolecular complex disassembly (GO:0032984)3.70828229
68rRNA metabolic process (GO:0016072)3.69930693
69mitochondrial respiratory chain complex assembly (GO:0033108)3.69509038
70establishment of integrated proviral latency (GO:0075713)3.69196311
71formation of translation preinitiation complex (GO:0001731)3.69047525
72inner mitochondrial membrane organization (GO:0007007)3.64991145
73chromatin remodeling at centromere (GO:0031055)3.64938800
74CENP-A containing nucleosome assembly (GO:0034080)3.61052248
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61012472
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61012472
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58859637
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57981843
79pseudouridine synthesis (GO:0001522)3.54902982
80establishment of protein localization to mitochondrion (GO:0072655)3.54469377
81oxidative phosphorylation (GO:0006119)3.52956946
82protein targeting to mitochondrion (GO:0006626)3.52508827
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52023431
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.52023431
85NADH dehydrogenase complex assembly (GO:0010257)3.52023431
86guanosine-containing compound biosynthetic process (GO:1901070)3.51470696
87* regulation of ubiquitin-protein transferase activity (GO:0051438)3.50256835
88spliceosomal snRNP assembly (GO:0000387)3.49198293
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43173098
90* regulation of ligase activity (GO:0051340)3.39915190
91purine nucleoside triphosphate biosynthetic process (GO:0009145)3.37118976
92peptidyl-histidine modification (GO:0018202)3.35530226
93* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.35529545
94* regulation of cellular amine metabolic process (GO:0033238)3.33577533
95protein targeting to membrane (GO:0006612)3.33071175
96DNA damage response, detection of DNA damage (GO:0042769)3.32529303
97protein localization to mitochondrion (GO:0070585)3.31674597
98* negative regulation of protein ubiquitination (GO:0031397)3.30746059
99transcription-coupled nucleotide-excision repair (GO:0006283)3.26910524
100* positive regulation of cell cycle arrest (GO:0071158)3.26777490
101establishment of viral latency (GO:0019043)3.24244848
102ATP biosynthetic process (GO:0006754)3.23426572
103spliceosomal complex assembly (GO:0000245)3.23344475
104rRNA modification (GO:0000154)3.21208536
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.20960834
106L-methionine salvage (GO:0071267)3.18201668
107L-methionine biosynthetic process (GO:0071265)3.18201668
108amino acid salvage (GO:0043102)3.18201668
109UTP metabolic process (GO:0046051)3.16873708
110telomere maintenance via semi-conservative replication (GO:0032201)3.13828889
111* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.13679829
112hydrogen ion transmembrane transport (GO:1902600)3.12885764
113* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.08726798
114purine nucleobase biosynthetic process (GO:0009113)3.05569215
115DNA strand elongation involved in DNA replication (GO:0006271)3.04307645
116histone exchange (GO:0043486)3.01546815
117maturation of 5.8S rRNA (GO:0000460)3.00960126
118mitochondrial transport (GO:0006839)2.95607566
119rRNA methylation (GO:0031167)2.95170409
120intracellular protein transmembrane import (GO:0044743)2.93747635
121ribosome assembly (GO:0042255)2.93089032
122ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92218410
123DNA catabolic process, exonucleolytic (GO:0000738)2.92154789
124* signal transduction in response to DNA damage (GO:0042770)2.91569322
125* G1/S transition of mitotic cell cycle (GO:0000082)2.91149741
126* cell cycle G1/S phase transition (GO:0044843)2.91149741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93496935
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46768432
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.26857097
4* EST1_17652178_ChIP-ChIP_JURKAT_Human4.20165061
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.16336096
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.95339865
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.93738448
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.92178520
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69721293
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34772996
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.25304926
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22974136
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20769126
14E2F7_22180533_ChIP-Seq_HELA_Human3.20308926
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19542706
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07303543
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00809738
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92327126
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85186422
20DCP1A_22483619_ChIP-Seq_HELA_Human2.67830432
21XRN2_22483619_ChIP-Seq_HELA_Human2.56957617
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55402571
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54529028
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.51262786
25* VDR_23849224_ChIP-Seq_CD4+_Human2.47342986
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36162261
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.24431734
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19294927
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.13779021
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09987163
31FOXP3_21729870_ChIP-Seq_TREG_Human2.07441871
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07215142
33TTF2_22483619_ChIP-Seq_HELA_Human2.03967961
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02565662
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99238604
36GABP_19822575_ChIP-Seq_HepG2_Human1.99113007
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.97456523
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93935955
39ELK1_19687146_ChIP-ChIP_HELA_Human1.82553625
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76634725
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71219034
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.68067764
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66576345
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64307602
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63332228
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61007443
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.60641674
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55899177
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55353848
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53469235
51KDM5A_27292631_Chip-Seq_BREAST_Human1.45168996
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45156269
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41409141
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38698495
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37679504
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37049623
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36655490
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35354721
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33828477
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29611695
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23367161
62ZNF274_21170338_ChIP-Seq_K562_Hela1.20290083
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.19489707
64* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18624507
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17850396
66MYC_18940864_ChIP-ChIP_HL60_Human1.17394530
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16101710
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09447591
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06052576
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.04634160
71SOX17_20123909_ChIP-Seq_XEN_Mouse1.04214491
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03620999
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03235906
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02423919
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01923489
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00805469
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98712083
78SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98354607
79OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97878302
80VDR_22108803_ChIP-Seq_LS180_Human0.93515429
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93103717
82AR_21909140_ChIP-Seq_LNCAP_Human0.90781394
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90720823
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89718836
85CIITA_25753668_ChIP-Seq_RAJI_Human0.87013823
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85190555
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84095356
88EWS_26573619_Chip-Seq_HEK293_Human0.83957752
89KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83943293
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81799461
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80065020
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79849108
93TFEB_21752829_ChIP-Seq_HELA_Human0.79587546
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79048891
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.78801446
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.76600614
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.76081402
98TP53_22573176_ChIP-Seq_HFKS_Human0.74956484
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74684584
100NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74383653
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74324397
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73803528
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73541644
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73494009
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73386189
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70485886
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69798629
108* FOXP1_21924763_ChIP-Seq_HESCs_Human0.69760788
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68059413
110IRF1_19129219_ChIP-ChIP_H3396_Human0.67918629
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67619338
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67619338
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67619338
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67434618
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.65292769
116HTT_18923047_ChIP-ChIP_STHdh_Human0.62738721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37890001
2MP0004957_abnormal_blastocyst_morpholog3.76117970
3MP0008932_abnormal_embryonic_tissue3.48684085
4MP0003806_abnormal_nucleotide_metabolis3.42987787
5MP0009379_abnormal_foot_pigmentation3.40542683
6MP0010030_abnormal_orbit_morphology3.34291701
7MP0001529_abnormal_vocalization3.06900480
8MP0003077_abnormal_cell_cycle2.82454363
9MP0003111_abnormal_nucleus_morphology2.77298698
10MP0003186_abnormal_redox_activity2.70186898
11MP0006035_abnormal_mitochondrial_morpho2.66440444
12MP0003718_maternal_effect2.63652582
13MP0003315_abnormal_perineum_morphology2.63429985
14MP0010094_abnormal_chromosome_stability2.53041514
15MP0008058_abnormal_DNA_repair2.41948599
16MP0001905_abnormal_dopamine_level2.39421519
17MP0006036_abnormal_mitochondrial_physio2.39275404
18MP0003941_abnormal_skin_development2.05778307
19MP0003136_yellow_coat_color2.02014023
20MP0008877_abnormal_DNA_methylation1.95505820
21MP0003786_premature_aging1.84589507
22MP0004133_heterotaxia1.79892078
23MP0008057_abnormal_DNA_replication1.79497735
24MP0002751_abnormal_autonomic_nervous1.78518099
25MP0001727_abnormal_embryo_implantation1.77398070
26MP0000358_abnormal_cell_content/1.66835634
27MP0002837_dystrophic_cardiac_calcinosis1.64043365
28MP0002102_abnormal_ear_morphology1.60072291
29MP0003123_paternal_imprinting1.59080335
30MP0001188_hyperpigmentation1.55046921
31MP0004142_abnormal_muscle_tone1.54322950
32MP0008007_abnormal_cellular_replicative1.54179149
33MP0002638_abnormal_pupillary_reflex1.49121376
34MP0004147_increased_porphyrin_level1.47892260
35MP0009697_abnormal_copulation1.41553789
36MP0001730_embryonic_growth_arrest1.38946976
37MP0008260_abnormal_autophagy1.37830429
38MP0006276_abnormal_autonomic_nervous1.35782541
39MP0000372_irregular_coat_pigmentation1.34975441
40MP0002938_white_spotting1.31859635
41MP0009333_abnormal_splenocyte_physiolog1.31481550
42MP0005394_taste/olfaction_phenotype1.29075519
43MP0005499_abnormal_olfactory_system1.29075519
44MP0002163_abnormal_gland_morphology1.28172287
45MP0000049_abnormal_middle_ear1.28128993
46MP0008875_abnormal_xenobiotic_pharmacok1.26942415
47MP0000750_abnormal_muscle_regeneration1.25935092
48MP0003195_calcinosis1.23163092
49MP0006072_abnormal_retinal_apoptosis1.23019187
50MP0005084_abnormal_gallbladder_morpholo1.20177981
51MP0000749_muscle_degeneration1.15360945
52MP0001984_abnormal_olfaction1.14577792
53MP0005075_abnormal_melanosome_morpholog1.14310170
54MP0001485_abnormal_pinna_reflex1.13314619
55MP0001986_abnormal_taste_sensitivity1.09734625
56MP0006292_abnormal_olfactory_placode1.08972377
57MP0002234_abnormal_pharynx_morphology1.05514402
58MP0000350_abnormal_cell_proliferation1.04679877
59MP0002090_abnormal_vision1.02421815
60MP0003938_abnormal_ear_development1.01240367
61MP0005408_hypopigmentation1.00529670
62MP0002277_abnormal_respiratory_mucosa0.99282999
63MP0008872_abnormal_physiological_respon0.98324527
64MP0001929_abnormal_gametogenesis0.98159339
65MP0002233_abnormal_nose_morphology0.95294006
66MP0001968_abnormal_touch/_nociception0.93470869
67MP0005551_abnormal_eye_electrophysiolog0.93312790
68MP0004742_abnormal_vestibular_system0.92723629
69MP0003567_abnormal_fetal_cardiomyocyte0.92525923
70MP0003011_delayed_dark_adaptation0.92076970
71MP0003937_abnormal_limbs/digits/tail_de0.91799546
72MP0008995_early_reproductive_senescence0.91583517
73MP0000647_abnormal_sebaceous_gland0.90831999
74MP0002160_abnormal_reproductive_system0.90460561
75MP0003890_abnormal_embryonic-extraembry0.90216913
76MP0005266_abnormal_metabolism0.89374830
77MP0002210_abnormal_sex_determination0.89341524
78MP0005451_abnormal_body_composition0.89233188
79MP0001697_abnormal_embryo_size0.88963043
80MP0000313_abnormal_cell_death0.88919525
81MP0008789_abnormal_olfactory_epithelium0.85342729
82MP0000516_abnormal_urinary_system0.84882960
83MP0005367_renal/urinary_system_phenotyp0.84882960
84MP0002095_abnormal_skin_pigmentation0.84116317
85MP0005332_abnormal_amino_acid0.82627878
86MP0002080_prenatal_lethality0.82173088
87MP0005395_other_phenotype0.80168412
88MP0002138_abnormal_hepatobiliary_system0.78526178
89MP0001764_abnormal_homeostasis0.78472628
90MP0002254_reproductive_system_inflammat0.78079966
91MP0003137_abnormal_impulse_conducting0.78038493
92MP0001145_abnormal_male_reproductive0.77482018
93MP0003646_muscle_fatigue0.77445176
94MP0002148_abnormal_hypersensitivity_rea0.77054735
95MP0005389_reproductive_system_phenotype0.75928962
96MP0005379_endocrine/exocrine_gland_phen0.75758316
97MP0001853_heart_inflammation0.75338662
98MP0001293_anophthalmia0.74986464
99MP0005330_cardiomyopathy0.74739153
100MP0002132_abnormal_respiratory_system0.72893434
101MP0001119_abnormal_female_reproductive0.72374144
102MP0000026_abnormal_inner_ear0.72059869
103MP0005409_darkened_coat_color0.71157985
104MP0002736_abnormal_nociception_after0.71074230
105MP0005636_abnormal_mineral_homeostasis0.71072354
106MP0003121_genomic_imprinting0.69675559
107MP0004215_abnormal_myocardial_fiber0.68490884
108MP0001542_abnormal_bone_strength0.67474215
109MP0005410_abnormal_fertilization0.67226129
110MP0003880_abnormal_central_pattern0.67084885
111MP0000858_altered_metastatic_potential0.65972289
112MP0002111_abnormal_tail_morphology0.65083732
113MP0001672_abnormal_embryogenesis/_devel0.64754055
114MP0005380_embryogenesis_phenotype0.64754055
115MP0003942_abnormal_urinary_system0.63903967
116MP0002332_abnormal_exercise_endurance0.63430674
117MP0005376_homeostasis/metabolism_phenot0.62690504
118MP0002085_abnormal_embryonic_tissue0.62673817
119MP0001324_abnormal_eye_pigmentation0.62114399
120MP0002282_abnormal_trachea_morphology0.61523710
121MP0003221_abnormal_cardiomyocyte_apopto0.60729867
122MP0001286_abnormal_eye_development0.60701552
123MP0000537_abnormal_urethra_morphology0.60279762
124MP0008873_increased_physiological_sensi0.60220708
125MP0009785_altered_susceptibility_to0.59974640
126MP0000653_abnormal_sex_gland0.59833826
127MP0004145_abnormal_muscle_electrophysio0.59436872
128MP0003119_abnormal_digestive_system0.58546205
129MP0003122_maternal_imprinting0.58500476
130MP0000613_abnormal_salivary_gland0.58173601
131MP0005253_abnormal_eye_physiology0.58021849
132MP0001919_abnormal_reproductive_system0.57592635
133MP0004381_abnormal_hair_follicle0.56338643
134MP0005248_abnormal_Harderian_gland0.55889635

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)6.40115283
2Abnormality of cells of the erythroid lineage (HP:0012130)6.08462735
3Acute necrotizing encephalopathy (HP:0006965)5.66656115
4Mitochondrial inheritance (HP:0001427)5.24967265
5Abnormal mitochondria in muscle tissue (HP:0008316)5.10879153
6Hepatocellular necrosis (HP:0001404)4.67918094
7Acute encephalopathy (HP:0006846)4.56495717
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.51037123
9Increased CSF lactate (HP:0002490)4.48793695
10Progressive macrocephaly (HP:0004481)4.45066963
11Abnormal number of erythroid precursors (HP:0012131)4.43499612
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.19342083
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.19342083
14Increased hepatocellular lipid droplets (HP:0006565)4.14575655
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.07823432
16Hepatic necrosis (HP:0002605)4.05137596
17Cerebral edema (HP:0002181)4.02099005
18Macrocytic anemia (HP:0001972)4.00379191
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.86048439
20Exercise intolerance (HP:0003546)3.85915878
21Abnormality of glycolysis (HP:0004366)3.79187758
22Increased serum pyruvate (HP:0003542)3.79187758
23Lipid accumulation in hepatocytes (HP:0006561)3.66242057
24Cerebral hypomyelination (HP:0006808)3.61107739
25Reticulocytopenia (HP:0001896)3.55837610
26Pallor (HP:0000980)3.48750323
273-Methylglutaconic aciduria (HP:0003535)3.47630311
28Increased serum lactate (HP:0002151)3.43689442
29Respiratory failure (HP:0002878)3.42218075
30Renal Fanconi syndrome (HP:0001994)3.41380597
31Stenosis of the external auditory canal (HP:0000402)3.37723758
32Lactic acidosis (HP:0003128)3.34358452
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19692497
34Type I transferrin isoform profile (HP:0003642)3.15660151
35Birth length less than 3rd percentile (HP:0003561)3.13381525
36Abnormality of placental membranes (HP:0011409)3.11222680
37Amniotic constriction ring (HP:0009775)3.11222680
38Breast hypoplasia (HP:0003187)3.05519163
39Colon cancer (HP:0003003)2.96055057
40Increased intramyocellular lipid droplets (HP:0012240)2.95367961
41Exertional dyspnea (HP:0002875)2.94357144
42Leukodystrophy (HP:0002415)2.93878755
43Abnormality of the labia minora (HP:0012880)2.91580651
44Optic disc pallor (HP:0000543)2.81325793
45Congenital ichthyosiform erythroderma (HP:0007431)2.71412962
46Progressive muscle weakness (HP:0003323)2.58819960
47Abnormal protein glycosylation (HP:0012346)2.55278930
48Abnormal glycosylation (HP:0012345)2.55278930
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55278930
50Abnormal protein N-linked glycosylation (HP:0012347)2.55278930
51Methylmalonic aciduria (HP:0012120)2.54681790
52Rough bone trabeculation (HP:0100670)2.52286739
53Parakeratosis (HP:0001036)2.50852542
54Abnormal hemoglobin (HP:0011902)2.44216639
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.41061157
56CNS demyelination (HP:0007305)2.38718514
57Degeneration of anterior horn cells (HP:0002398)2.38456628
58Abnormality of the anterior horn cell (HP:0006802)2.38456628
59Poor head control (HP:0002421)2.38191479
60Increased muscle lipid content (HP:0009058)2.38153467
61Oral leukoplakia (HP:0002745)2.36698759
62Methylmalonic acidemia (HP:0002912)2.35606412
63Emotional lability (HP:0000712)2.33054854
64Respiratory difficulties (HP:0002880)2.30066116
65Aplasia/hypoplasia of the uterus (HP:0008684)2.29287675
66Abnormality of alanine metabolism (HP:0010916)2.27778352
67Hyperalaninemia (HP:0003348)2.27778352
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27778352
69Carpal bone hypoplasia (HP:0001498)2.23208326
70Meckel diverticulum (HP:0002245)2.23017683
71Horseshoe kidney (HP:0000085)2.22269205
72Reduced antithrombin III activity (HP:0001976)2.22156288
73X-linked dominant inheritance (HP:0001423)2.19495211
74Hyperglycinemia (HP:0002154)2.18315950
75Hyperphosphaturia (HP:0003109)2.16161483
76Abnormality of serum amino acid levels (HP:0003112)2.15949743
77Sparse eyelashes (HP:0000653)2.15306159
78Generalized aminoaciduria (HP:0002909)2.14169749
79Trismus (HP:0000211)2.13605171
80Abnormality of the ileum (HP:0001549)2.11159613
81Congenital, generalized hypertrichosis (HP:0004540)2.07215540
82Abnormality of methionine metabolism (HP:0010901)2.06368988
83Septo-optic dysplasia (HP:0100842)2.05974977
84Abnormality of renal resorption (HP:0011038)2.03967786
85Abnormal trabecular bone morphology (HP:0100671)2.02618656
86Absent thumb (HP:0009777)1.96639766
87Patellar aplasia (HP:0006443)1.94849777
88Abnormalities of placenta or umbilical cord (HP:0001194)1.93828720
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93446758
90Type 2 muscle fiber atrophy (HP:0003554)1.92737535
91Dicarboxylic aciduria (HP:0003215)1.89676354
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89676354
93Poor suck (HP:0002033)1.89016101
94Aplasia/Hypoplasia of the patella (HP:0006498)1.88777418
95Testicular atrophy (HP:0000029)1.88529154
96Pancreatic cysts (HP:0001737)1.88470856
97Lethargy (HP:0001254)1.87978595
98CNS hypomyelination (HP:0003429)1.85458863
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.85448608
100Secondary amenorrhea (HP:0000869)1.85280166
101Progressive external ophthalmoplegia (HP:0000590)1.84604116
102Abnormal number of incisors (HP:0011064)1.84207302
103Abnormality of the preputium (HP:0100587)1.83558357
104Hypoplasia of the uterus (HP:0000013)1.83382815
105Pancreatic fibrosis (HP:0100732)1.82484802
106Aplasia of the musculature (HP:0100854)1.82360849
107Muscle fiber atrophy (HP:0100295)1.82247299
108Abnormality of the umbilical cord (HP:0010881)1.79491739
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78884053
110Molar tooth sign on MRI (HP:0002419)1.77890122
111Abnormality of midbrain morphology (HP:0002418)1.77890122
112Aplastic anemia (HP:0001915)1.77690466
113Neoplasm of the adrenal gland (HP:0100631)1.77007501
114Cellular immunodeficiency (HP:0005374)1.76055459
115Irregular epiphyses (HP:0010582)1.75989505
116Hypoplasia of the pons (HP:0012110)1.75223540
117Hypoplasia of the radius (HP:0002984)1.73993048
118True hermaphroditism (HP:0010459)1.73553273
119Conical tooth (HP:0000698)1.72941175
120Hypoplastic pelvis (HP:0008839)1.72324781
121Prolonged neonatal jaundice (HP:0006579)1.71724408
122Absent septum pellucidum (HP:0001331)1.71339999
123Glycosuria (HP:0003076)1.70008204
124Abnormality of urine glucose concentration (HP:0011016)1.70008204
125Sclerocornea (HP:0000647)1.69167347
126Delusions (HP:0000746)1.68078887
127Abnormality of the pons (HP:0007361)1.67012918
128Abnormal urine phosphate concentration (HP:0012599)1.66760705
129Blindness (HP:0000618)1.66749939
130Pancytopenia (HP:0001876)1.64596221
131Abnormal lung lobation (HP:0002101)1.64565656
132Multiple enchondromatosis (HP:0005701)1.64426030
133Spastic paraparesis (HP:0002313)1.63767232
134Premature graying of hair (HP:0002216)1.62357394
135Postnatal microcephaly (HP:0005484)1.62335797
136Depressed nasal ridge (HP:0000457)1.62036627
137Facial cleft (HP:0002006)1.61903358
138Gliosis (HP:0002171)1.60103013
139Hypoplastic heart (HP:0001961)1.59720830
140Microretrognathia (HP:0000308)1.59339483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.40257992
2VRK25.14745295
3EIF2AK15.11310710
4NME23.66758648
5STK163.16289853
6EIF2AK33.04241069
7PBK2.89091271
8TLK12.76433932
9NME12.56537610
10WEE12.42695104
11PLK42.31850812
12TRIM282.22982111
13SRPK12.15959898
14NUAK12.08966174
15ARAF1.99301045
16PDK21.91495041
17PIM21.83727663
18TAF11.78483185
19VRK11.71873626
20RPS6KB21.71573370
21WNK31.61151151
22BRAF1.54666105
23MKNK11.50098911
24PNCK1.43816402
25CDC71.42025783
26TESK21.35949000
27DYRK21.35243885
28BRSK11.33773860
29ABL21.33356108
30MAP4K21.30311135
31LIMK11.27699970
32TSSK61.25326846
33ILK1.22114103
34AURKA1.21022677
35EPHA21.17867532
36MST41.15920777
37STK391.15244489
38MKNK21.14324259
39MAP3K121.13519079
40BMPR1B1.12999647
41BRSK21.12437090
42PLK11.09916942
43BCR1.07971510
44CSNK1G11.05458461
45TNIK1.02129826
46EIF2AK21.01677482
47IRAK31.00496165
48MAP3K111.00053598
49DAPK10.99700374
50PAK10.97052552
51PINK10.91835394
52ZAK0.90584235
53PLK30.90014088
54MUSK0.89845594
55CSNK1G20.88541726
56ACVR1B0.88053103
57CDK190.86286915
58GRK10.84145675
59AURKB0.82483595
60CASK0.81904391
61DYRK30.81112960
62KDR0.80609221
63CSNK1A1L0.79407986
64MYLK0.77851074
65MAP2K70.75181833
66TTK0.72571663
67CSNK2A10.71615554
68RPS6KA50.69928968
69IRAK40.69466192
70CDK70.68380093
71TESK10.65690400
72OBSCN0.65182530
73GRK70.64284394
74CSNK2A20.62655145
75ADRBK20.62579292
76INSRR0.60673915
77ERBB40.56682463
78OXSR10.55535223
79TIE10.55060337
80PRKCI0.55007383
81RPS6KA40.53925901
82CSNK1G30.52570435
83UHMK10.51809987
84CHEK20.51804780
85IRAK20.51565860
86CDK80.51507905
87EPHB20.49528912
88PAK40.48684714
89ROCK20.47210973
90MELK0.46318847
91STK38L0.46024040
92TGFBR10.44793265
93PRKCG0.44356232
94CDK140.44174395
95STK40.43414034
96WNK40.42740961
97PLK20.42605984
98TXK0.41933340
99DAPK30.41319453
100ATM0.39667751
101MINK10.39648174
102ADRBK10.37609770
103CSNK1A10.36273419
104PHKG20.36010009
105PHKG10.36010009
106NEK20.35920887
107BCKDK0.35558084
108MAP3K80.34995604
109STK100.34906953
110STK240.34875606
111CDK11A0.34845082
112PASK0.34629749
113CDK180.34267453
114MAPKAPK50.33116802
115NEK10.33022532
116CDK150.32583670
117ERBB30.31988719
118FRK0.31953726
119RPS6KC10.31868969
120RPS6KL10.31868969
121ATR0.31610527
122GRK50.31365313
123YES10.31229591
124CSNK1E0.29863842
125FGFR10.29258464
126EPHA40.28915225
127CAMK2B0.28382980
128IRAK10.27665262
129CHEK10.27061748
130CCNB10.27024380
131ALK0.26869966
132CAMK2G0.25834613
133PRKCD0.25433746
134LRRK20.25407036

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.46372245
2* Proteasome_Homo sapiens_hsa030505.19945996
3Oxidative phosphorylation_Homo sapiens_hsa001904.42778108
4Parkinsons disease_Homo sapiens_hsa050123.96063150
5RNA polymerase_Homo sapiens_hsa030203.87160514
6Huntingtons disease_Homo sapiens_hsa050162.92688909
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75594136
8DNA replication_Homo sapiens_hsa030302.75100873
9Alzheimers disease_Homo sapiens_hsa050102.61299912
10Mismatch repair_Homo sapiens_hsa034302.61259677
11Spliceosome_Homo sapiens_hsa030402.42981373
12Protein export_Homo sapiens_hsa030602.36855315
13Pyrimidine metabolism_Homo sapiens_hsa002402.32607130
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31359072
15Homologous recombination_Homo sapiens_hsa034401.99381082
16Nucleotide excision repair_Homo sapiens_hsa034201.93116202
17RNA transport_Homo sapiens_hsa030131.83127011
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62646966
19Base excision repair_Homo sapiens_hsa034101.53107882
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44135907
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40780395
22Cardiac muscle contraction_Homo sapiens_hsa042601.32533455
23Basal transcription factors_Homo sapiens_hsa030221.32248813
24One carbon pool by folate_Homo sapiens_hsa006701.27070917
25Cell cycle_Homo sapiens_hsa041101.25041287
26RNA degradation_Homo sapiens_hsa030181.24067613
27Purine metabolism_Homo sapiens_hsa002301.23303522
28Fanconi anemia pathway_Homo sapiens_hsa034601.13966933
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04676591
30Folate biosynthesis_Homo sapiens_hsa007901.04559034
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02075052
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99607883
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94355365
34Fatty acid elongation_Homo sapiens_hsa000620.93615127
35Steroid biosynthesis_Homo sapiens_hsa001000.93238924
36Collecting duct acid secretion_Homo sapiens_hsa049660.92348059
37Non-homologous end-joining_Homo sapiens_hsa034500.90339501
38Glutathione metabolism_Homo sapiens_hsa004800.87883163
39Epstein-Barr virus infection_Homo sapiens_hsa051690.87278675
40Biosynthesis of amino acids_Homo sapiens_hsa012300.81436915
41Butanoate metabolism_Homo sapiens_hsa006500.81081516
42Selenocompound metabolism_Homo sapiens_hsa004500.79688966
43Vibrio cholerae infection_Homo sapiens_hsa051100.79417126
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77646946
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.73352538
46Metabolic pathways_Homo sapiens_hsa011000.72767803
47Sulfur relay system_Homo sapiens_hsa041220.70912258
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70049538
49Carbon metabolism_Homo sapiens_hsa012000.70000798
50Fructose and mannose metabolism_Homo sapiens_hsa000510.68231742
51Pentose phosphate pathway_Homo sapiens_hsa000300.62888076
52Systemic lupus erythematosus_Homo sapiens_hsa053220.61741059
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60473436
54Phagosome_Homo sapiens_hsa041450.60053171
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59210712
56Phototransduction_Homo sapiens_hsa047440.57165825
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56157774
58Tryptophan metabolism_Homo sapiens_hsa003800.55846476
59N-Glycan biosynthesis_Homo sapiens_hsa005100.55402133
60Arachidonic acid metabolism_Homo sapiens_hsa005900.54780307
61Rheumatoid arthritis_Homo sapiens_hsa053230.54566931
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52659415
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52579723
64beta-Alanine metabolism_Homo sapiens_hsa004100.50798993
65Caffeine metabolism_Homo sapiens_hsa002320.49947419
66Regulation of autophagy_Homo sapiens_hsa041400.49620593
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49570684
68Fatty acid metabolism_Homo sapiens_hsa012120.48454381
69Phenylalanine metabolism_Homo sapiens_hsa003600.47980096
70Sulfur metabolism_Homo sapiens_hsa009200.47595851
71mRNA surveillance pathway_Homo sapiens_hsa030150.47575330
72Fatty acid degradation_Homo sapiens_hsa000710.46627707
73Vitamin digestion and absorption_Homo sapiens_hsa049770.45653185
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.44489325
75Arginine and proline metabolism_Homo sapiens_hsa003300.44325733
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43848746
77Vitamin B6 metabolism_Homo sapiens_hsa007500.43077581
78Graft-versus-host disease_Homo sapiens_hsa053320.42419870
79p53 signaling pathway_Homo sapiens_hsa041150.41492241
80Tyrosine metabolism_Homo sapiens_hsa003500.41038667
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39480946
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39299992
83Sphingolipid metabolism_Homo sapiens_hsa006000.38869932
84Chemical carcinogenesis_Homo sapiens_hsa052040.38769493
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37673409
86Linoleic acid metabolism_Homo sapiens_hsa005910.35821592
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35413551
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.33201378
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.32880217
90Ether lipid metabolism_Homo sapiens_hsa005650.30631183
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29655063
92Allograft rejection_Homo sapiens_hsa053300.29654819
93Pyruvate metabolism_Homo sapiens_hsa006200.29414335
94Nitrogen metabolism_Homo sapiens_hsa009100.29266766
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28608765
96Oocyte meiosis_Homo sapiens_hsa041140.27467271
97Retinol metabolism_Homo sapiens_hsa008300.26491169
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26053515
99Alcoholism_Homo sapiens_hsa050340.25345966
100Fat digestion and absorption_Homo sapiens_hsa049750.25345229
101Legionellosis_Homo sapiens_hsa051340.24011526
102Asthma_Homo sapiens_hsa053100.23658583
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20422307
104Peroxisome_Homo sapiens_hsa041460.19919850
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18598858
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18212459
107Primary immunodeficiency_Homo sapiens_hsa053400.17404972
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16798309
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15176259
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14664797
111Hedgehog signaling pathway_Homo sapiens_hsa043400.14368421
112Basal cell carcinoma_Homo sapiens_hsa052170.13699030
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13655980
114Type I diabetes mellitus_Homo sapiens_hsa049400.13609416
115Autoimmune thyroid disease_Homo sapiens_hsa053200.12326303
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11158330
117Galactose metabolism_Homo sapiens_hsa000520.10181023
118Herpes simplex infection_Homo sapiens_hsa051680.10016279
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08809353
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07421295
121Antigen processing and presentation_Homo sapiens_hsa046120.06091859
122Histidine metabolism_Homo sapiens_hsa003400.05551612
123Viral carcinogenesis_Homo sapiens_hsa052030.04805007
124Apoptosis_Homo sapiens_hsa042100.04115568
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.03269327
126Propanoate metabolism_Homo sapiens_hsa006400.02388160

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