PSMB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.54690656
2translational termination (GO:0006415)6.40287810
3ribosomal small subunit assembly (GO:0000028)6.01568407
4translational elongation (GO:0006414)5.81373402
5ribosomal small subunit biogenesis (GO:0042274)5.67434372
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.60348243
7protein targeting to ER (GO:0045047)5.48146447
8cotranslational protein targeting to membrane (GO:0006613)5.47266058
9maturation of SSU-rRNA (GO:0030490)5.44517482
10translational initiation (GO:0006413)5.41667887
11ribosomal large subunit biogenesis (GO:0042273)5.39785272
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.21955396
13protein localization to endoplasmic reticulum (GO:0070972)5.17219386
14DNA deamination (GO:0045006)5.14207899
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.07593858
16viral life cycle (GO:0019058)5.03137734
17cellular protein complex disassembly (GO:0043624)5.00398995
18formation of translation preinitiation complex (GO:0001731)5.00039476
19ribonucleoprotein complex biogenesis (GO:0022613)4.51407392
20proteasome assembly (GO:0043248)4.47041438
21translation (GO:0006412)4.43820895
22folic acid-containing compound biosynthetic process (GO:0009396)4.40750340
23protein complex disassembly (GO:0043241)4.38599626
24macromolecular complex disassembly (GO:0032984)4.17866518
25ribosome assembly (GO:0042255)4.10024249
26DNA strand elongation involved in DNA replication (GO:0006271)3.99067451
27chaperone-mediated protein transport (GO:0072321)3.98126746
28* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89339918
29nucleobase biosynthetic process (GO:0046112)3.86379397
30ribosome biogenesis (GO:0042254)3.85145881
31purine nucleobase biosynthetic process (GO:0009113)3.78602288
32spliceosomal snRNP assembly (GO:0000387)3.75177850
33DNA strand elongation (GO:0022616)3.73045405
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70739965
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69830429
36folic acid metabolic process (GO:0046655)3.69235709
37protein targeting to membrane (GO:0006612)3.68972795
38* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66543123
39rRNA processing (GO:0006364)3.64562770
40respiratory electron transport chain (GO:0022904)3.64166421
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.63714234
42cellular component biogenesis (GO:0044085)3.61406640
43* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57473111
44* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57281569
45electron transport chain (GO:0022900)3.56192102
46* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55509962
47* negative regulation of ligase activity (GO:0051352)3.55509962
48telomere maintenance via semi-conservative replication (GO:0032201)3.53907528
49pteridine-containing compound biosynthetic process (GO:0042559)3.53266694
50DNA unwinding involved in DNA replication (GO:0006268)3.51904443
51* positive regulation of cell cycle arrest (GO:0071158)3.51882549
52* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.51495329
53DNA replication initiation (GO:0006270)3.51315817
54rRNA metabolic process (GO:0016072)3.49547099
55protein targeting to mitochondrion (GO:0006626)3.49461060
56DNA replication checkpoint (GO:0000076)3.44728300
57* regulation of cellular amino acid metabolic process (GO:0006521)3.44134934
58* regulation of cellular amine metabolic process (GO:0033238)3.43144716
59mRNA catabolic process (GO:0006402)3.41037216
60pseudouridine synthesis (GO:0001522)3.40990036
61inner mitochondrial membrane organization (GO:0007007)3.38890208
62regulation of mitochondrial translation (GO:0070129)3.38843271
63ATP synthesis coupled proton transport (GO:0015986)3.38232127
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38232127
65nucleobase-containing small molecule interconversion (GO:0015949)3.37246633
66respiratory chain complex IV assembly (GO:0008535)3.37002486
67rRNA methylation (GO:0031167)3.36221880
68* negative regulation of protein ubiquitination (GO:0031397)3.33946851
69* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31213213
70* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30163939
71* G1/S transition of mitotic cell cycle (GO:0000082)3.28523556
72* cell cycle G1/S phase transition (GO:0044843)3.28523556
73RNA catabolic process (GO:0006401)3.28488720
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26197847
75chromatin remodeling at centromere (GO:0031055)3.24929374
76* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23025095
77* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23025095
78* signal transduction involved in DNA damage checkpoint (GO:0072422)3.21984698
79* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21984698
80CENP-A containing nucleosome assembly (GO:0034080)3.21927971
81* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21792033
82* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21240375
83* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21240375
84* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21240375
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.19862230
86* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.19218662
87* positive regulation of ligase activity (GO:0051351)3.17991943
88protein complex biogenesis (GO:0070271)3.17102004
89IMP biosynthetic process (GO:0006188)3.16775174
90* signal transduction involved in cell cycle checkpoint (GO:0072395)3.15698629
91protein K6-linked ubiquitination (GO:0085020)3.15385216
92transcription elongation from RNA polymerase III promoter (GO:0006385)3.14507563
93termination of RNA polymerase III transcription (GO:0006386)3.14507563
94protein localization to mitochondrion (GO:0070585)3.14380237
95* signal transduction in response to DNA damage (GO:0042770)3.11250318
96DNA replication-dependent nucleosome assembly (GO:0006335)3.10785716
97DNA replication-dependent nucleosome organization (GO:0034723)3.10785716
98spliceosomal complex assembly (GO:0000245)3.09977543
99mitochondrial respiratory chain complex assembly (GO:0033108)3.08997759
100rRNA modification (GO:0000154)3.07208868
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02548587
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02377615
103* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02149245
104glycine metabolic process (GO:0006544)3.01947131
105cytochrome complex assembly (GO:0017004)3.01854237
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00418162
107cullin deneddylation (GO:0010388)2.99682655
108tRNA aminoacylation (GO:0043039)2.99407946
109amino acid activation (GO:0043038)2.99407946
110* regulation of cell cycle arrest (GO:0071156)2.98902596
111mitotic recombination (GO:0006312)2.98891590
112* negative regulation of cell cycle G1/S phase transition (GO:1902807)2.98463326
113* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.98463326
114lactate metabolic process (GO:0006089)2.96889325
115mitotic sister chromatid segregation (GO:0000070)2.96538714
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95568650
117oxidative phosphorylation (GO:0006119)2.95074225
118establishment of protein localization to mitochondrion (GO:0072655)2.94783361
119* regulation of ubiquitin-protein transferase activity (GO:0051438)2.92560307
120protein deneddylation (GO:0000338)2.91480475
121metaphase plate congression (GO:0051310)2.91469093
122establishment of viral latency (GO:0019043)2.90805323
123telomere maintenance via recombination (GO:0000722)2.90690447
124ncRNA 3-end processing (GO:0043628)2.90338112
125melanin biosynthetic process (GO:0042438)2.89366783
126establishment of integrated proviral latency (GO:0075713)2.87095313
127peptidyl-arginine omega-N-methylation (GO:0035247)2.86172306
128de novo protein folding (GO:0006458)2.84818580
129chaperone-mediated protein complex assembly (GO:0051131)2.84686386
130IMP metabolic process (GO:0046040)2.84088044
131tRNA aminoacylation for protein translation (GO:0006418)2.84078725
132histone arginine methylation (GO:0034969)2.83743166
133* regulation of ligase activity (GO:0051340)2.83194322
134transcription-coupled nucleotide-excision repair (GO:0006283)2.82527419
135tetrahydrofolate metabolic process (GO:0046653)2.82218492
136mitotic metaphase plate congression (GO:0007080)2.81994938
137UTP biosynthetic process (GO:0006228)2.80770359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16213657
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53201119
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.32410782
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18836370
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.16508658
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.14266857
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08755959
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06334726
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03222506
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.97916417
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93086558
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81018927
13* XRN2_22483619_ChIP-Seq_HELA_Human2.58456512
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42415495
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39134086
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38285136
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36555864
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.36514590
19E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25905311
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25301139
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25037900
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24791100
23DCP1A_22483619_ChIP-Seq_HELA_Human2.20871279
24* VDR_23849224_ChIP-Seq_CD4+_Human2.12967423
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08750162
26GABP_19822575_ChIP-Seq_HepG2_Human2.00788155
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97946435
28TTF2_22483619_ChIP-Seq_HELA_Human1.93093862
29FOXP3_21729870_ChIP-Seq_TREG_Human1.81334198
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80498703
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80160518
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79072859
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75927856
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71916352
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70378181
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70172191
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.68748041
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67693684
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64680738
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62958635
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61313424
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60110353
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58956875
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56538540
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56291127
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55555251
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55178219
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52518922
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50640726
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48416508
51AR_21909140_ChIP-Seq_LNCAP_Human1.47177246
52CIITA_25753668_ChIP-Seq_RAJI_Human1.42764802
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.39869026
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39312129
55ELK1_19687146_ChIP-ChIP_HELA_Human1.37020047
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35234193
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34218244
58* KDM5A_27292631_Chip-Seq_BREAST_Human1.33283383
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31916675
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.30235853
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29764270
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29754046
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29150792
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28494625
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25330090
66ZNF263_19887448_ChIP-Seq_K562_Human1.25195452
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24096577
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23724076
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23644017
70TFEB_21752829_ChIP-Seq_HELA_Human1.23548881
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21993733
72MYC_22102868_ChIP-Seq_BL_Human1.20354338
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19342949
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19259609
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18530166
76* ELK1_22589737_ChIP-Seq_MCF10A_Human1.18346569
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17047043
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16995738
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16989660
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16751499
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16671515
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16633013
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16392881
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16094168
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15097580
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13416398
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12986385
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.11429621
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08769333
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08025297
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03841771
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03341864
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03313463
94VDR_21846776_ChIP-Seq_THP-1_Human1.00091946
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98869549
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.97483029
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97132628
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97085984
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95680538
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.94952661
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92915887
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92903946
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92749013
104MYC_18940864_ChIP-ChIP_HL60_Human0.92698828
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90840279
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.90087225
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88748763
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88147685
109* ATF3_27146783_Chip-Seq_COLON_Human0.87177044
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.86845072
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86397383
112ELF5_23300383_ChIP-Seq_T47D_Human0.85787072
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85132211
114* NANOG_16153702_ChIP-ChIP_HESCs_Human0.84014975
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82755359
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82489293
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80048092
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77816588
119* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74833872
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72787662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63244634
2MP0000372_irregular_coat_pigmentation4.85420628
3MP0004957_abnormal_blastocyst_morpholog4.69314027
4MP0003806_abnormal_nucleotide_metabolis3.69730526
5MP0003111_abnormal_nucleus_morphology3.60914203
6MP0005408_hypopigmentation3.59516963
7MP0003077_abnormal_cell_cycle3.32826290
8MP0009379_abnormal_foot_pigmentation3.26856498
9MP0005171_absent_coat_pigmentation3.14021871
10MP0010094_abnormal_chromosome_stability2.99635294
11MP0003136_yellow_coat_color2.94924037
12MP0005075_abnormal_melanosome_morpholog2.85945116
13MP0002938_white_spotting2.83176748
14MP0008932_abnormal_embryonic_tissue2.82198862
15MP0003186_abnormal_redox_activity2.49322698
16MP0003123_paternal_imprinting2.40268301
17MP0001730_embryonic_growth_arrest2.36926280
18MP0008058_abnormal_DNA_repair2.12561721
19MP0009840_abnormal_foam_cell2.12557821
20MP0000015_abnormal_ear_pigmentation2.04157412
21MP0006036_abnormal_mitochondrial_physio2.03726889
22MP0009697_abnormal_copulation1.94409438
23MP0010352_gastrointestinal_tract_polyps1.93858317
24MP0008007_abnormal_cellular_replicative1.85450309
25MP0000350_abnormal_cell_proliferation1.84267263
26MP0000358_abnormal_cell_content/1.81513783
27MP0002139_abnormal_hepatobiliary_system1.76292087
28MP0003718_maternal_effect1.75727287
29MP0006035_abnormal_mitochondrial_morpho1.68373856
30MP0002095_abnormal_skin_pigmentation1.66897576
31MP0002102_abnormal_ear_morphology1.64087152
32MP0001697_abnormal_embryo_size1.63932647
33MP0002080_prenatal_lethality1.63503935
34MP0005174_abnormal_tail_pigmentation1.56922862
35MP0002163_abnormal_gland_morphology1.56755440
36MP0000750_abnormal_muscle_regeneration1.56734988
37MP0004381_abnormal_hair_follicle1.52259210
38MP0003705_abnormal_hypodermis_morpholog1.47508469
39MP0009333_abnormal_splenocyte_physiolog1.44190610
40MP0000537_abnormal_urethra_morphology1.43498638
41MP0001672_abnormal_embryogenesis/_devel1.42630487
42MP0005380_embryogenesis_phenotype1.42630487
43MP0000313_abnormal_cell_death1.37871768
44MP0003567_abnormal_fetal_cardiomyocyte1.35944232
45MP0002090_abnormal_vision1.34233123
46MP0010234_abnormal_vibrissa_follicle1.34009172
47MP0000371_diluted_coat_color1.33117013
48MP0003786_premature_aging1.33030856
49MP0003119_abnormal_digestive_system1.31991029
50MP0004133_heterotaxia1.29849033
51MP0003221_abnormal_cardiomyocyte_apopto1.29512494
52MP0003984_embryonic_growth_retardation1.28170802
53MP0002088_abnormal_embryonic_growth/wei1.28058439
54MP0003950_abnormal_plasma_membrane1.26925564
55MP0005379_endocrine/exocrine_gland_phen1.26114535
56MP0010030_abnormal_orbit_morphology1.24903921
57MP0002085_abnormal_embryonic_tissue1.23891375
58MP0001324_abnormal_eye_pigmentation1.23577790
59MP0002019_abnormal_tumor_incidence1.19561904
60MP0008877_abnormal_DNA_methylation1.18542925
61MP0000490_abnormal_crypts_of1.18424143
62MP0000858_altered_metastatic_potential1.17462982
63MP0002877_abnormal_melanocyte_morpholog1.16846367
64MP0009053_abnormal_anal_canal1.13452363
65MP0003941_abnormal_skin_development1.12024114
66MP0002084_abnormal_developmental_patter1.10675377
67MP0002086_abnormal_extraembryonic_tissu1.09878127
68MP0005360_urolithiasis1.09801175
69MP0001186_pigmentation_phenotype1.09471398
70MP0008057_abnormal_DNA_replication1.09102306
71MP0004197_abnormal_fetal_growth/weight/1.09082539
72MP0005332_abnormal_amino_acid1.09000210
73MP0000647_abnormal_sebaceous_gland1.07771013
74MP0010307_abnormal_tumor_latency1.07584741
75MP0002075_abnormal_coat/hair_pigmentati1.03765271
76MP0005083_abnormal_biliary_tract1.02342340
77MP0008995_early_reproductive_senescence1.00249933
78MP0005319_abnormal_enzyme/_coenzyme0.99887199
79MP0003315_abnormal_perineum_morphology0.98203414
80MP0001764_abnormal_homeostasis0.96477953
81MP0005670_abnormal_white_adipose0.95176792
82MP0002751_abnormal_autonomic_nervous0.93846524
83MP0000598_abnormal_liver_morphology0.93262207
84MP0001661_extended_life_span0.93073667
85MP0002837_dystrophic_cardiac_calcinosis0.92838476
86MP0008875_abnormal_xenobiotic_pharmacok0.91635845
87MP0005501_abnormal_skin_physiology0.91206058
88MP0005023_abnormal_wound_healing0.90355886
89MP0009672_abnormal_birth_weight0.89424601
90MP0005085_abnormal_gallbladder_physiolo0.88300038
91MP0001293_anophthalmia0.85275320
92MP0001727_abnormal_embryo_implantation0.85077452
93MP0001853_heart_inflammation0.84322562
94MP0002254_reproductive_system_inflammat0.84248210
95MP0002111_abnormal_tail_morphology0.83990905
96MP0009643_abnormal_urine_homeostasis0.83021458
97MP0001881_abnormal_mammary_gland0.82742743
98MP0001929_abnormal_gametogenesis0.81950160
99MP0005266_abnormal_metabolism0.81528380
100MP0002160_abnormal_reproductive_system0.81114166
101MP0005384_cellular_phenotype0.80378383
102MP0005220_abnormal_exocrine_pancreas0.78212262
103MP0002269_muscular_atrophy0.77986822
104MP0005636_abnormal_mineral_homeostasis0.77857856
105MP0003656_abnormal_erythrocyte_physiolo0.77527202
106MP0002132_abnormal_respiratory_system0.77234309
107MP0005389_reproductive_system_phenotype0.77000033
108MP0003011_delayed_dark_adaptation0.76923380
109MP0000609_abnormal_liver_physiology0.76299690
110MP0003566_abnormal_cell_adhesion0.76135256
111MP0003195_calcinosis0.75731832
112MP0005330_cardiomyopathy0.75678040
113MP0000653_abnormal_sex_gland0.73575395
114MP0005197_abnormal_uvea_morphology0.73371383
115MP0005395_other_phenotype0.72115755
116MP0006054_spinal_hemorrhage0.71919478
117MP0002653_abnormal_ependyma_morphology0.71806207
118MP0000747_muscle_weakness0.71760105
119MP0002638_abnormal_pupillary_reflex0.71511749
120MP0004147_increased_porphyrin_level0.70571581
121MP0005084_abnormal_gallbladder_morpholo0.69648693
122MP0001919_abnormal_reproductive_system0.69562220
123MP0004185_abnormal_adipocyte_glucose0.69083546
124MP0001119_abnormal_female_reproductive0.65811783
125MP0001756_abnormal_urination0.65736425
126MP0002722_abnormal_immune_system0.64139700
127MP0001542_abnormal_bone_strength0.63928840
128MP0001145_abnormal_male_reproductive0.63840301
129MP0001529_abnormal_vocalization0.63701502
130MP0000477_abnormal_intestine_morphology0.62431986
131MP0002210_abnormal_sex_determination0.62398974
132MP0005621_abnormal_cell_physiology0.62367183
133MP0002396_abnormal_hematopoietic_system0.62129200
134MP0000749_muscle_degeneration0.61896665
135MP0001545_abnormal_hematopoietic_system0.60330503
136MP0005397_hematopoietic_system_phenotyp0.60330503
137MP0003646_muscle_fatigue0.59999045
138MP0000627_abnormal_mammary_gland0.59957841
139MP0000703_abnormal_thymus_morphology0.59836604
140MP0003878_abnormal_ear_physiology0.59574867
141MP0005377_hearing/vestibular/ear_phenot0.59574867
142MP0004019_abnormal_vitamin_homeostasis0.59533945
143MP0008260_abnormal_autophagy0.59389259
144MP0005076_abnormal_cell_differentiation0.59353905
145MP0001346_abnormal_lacrimal_gland0.58673799
146MP0006072_abnormal_retinal_apoptosis0.58058391
147MP0005257_abnormal_intraocular_pressure0.58048710
148MP0005253_abnormal_eye_physiology0.56690347
149MP0000689_abnormal_spleen_morphology0.56127245
150MP0000613_abnormal_salivary_gland0.55978723
151MP0003937_abnormal_limbs/digits/tail_de0.54694046
152MP0008873_increased_physiological_sensi0.53384948

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.54244709
2Reticulocytopenia (HP:0001896)5.06891276
3Abnormal number of erythroid precursors (HP:0012131)5.03342763
4Macrocytic anemia (HP:0001972)4.38044937
5Multiple enchondromatosis (HP:0005701)3.98272796
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81587697
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81587697
8Pallor (HP:0000980)3.76387945
9Hepatocellular necrosis (HP:0001404)3.54841208
10Acute necrotizing encephalopathy (HP:0006965)3.54213431
11Trismus (HP:0000211)3.52463065
12Abnormal mitochondria in muscle tissue (HP:0008316)3.52081826
13Hepatic necrosis (HP:0002605)3.50241282
14Oral leukoplakia (HP:0002745)3.39829208
15Cerebral hypomyelination (HP:0006808)3.32690018
16Mitochondrial inheritance (HP:0001427)3.31881941
17Degeneration of anterior horn cells (HP:0002398)3.26768612
18Abnormality of the anterior horn cell (HP:0006802)3.26768612
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24845635
20Breast hypoplasia (HP:0003187)3.24205948
21Renal Fanconi syndrome (HP:0001994)3.23998638
22Acute encephalopathy (HP:0006846)3.21560180
23Microretrognathia (HP:0000308)3.18923996
24Increased CSF lactate (HP:0002490)3.18178014
25Progressive muscle weakness (HP:0003323)3.12211636
26Patchy hypopigmentation of hair (HP:0011365)3.07720027
27Birth length less than 3rd percentile (HP:0003561)3.05540918
28Increased serum lactate (HP:0002151)3.02951929
29Type I transferrin isoform profile (HP:0003642)2.96823996
30Chromsome breakage (HP:0040012)2.86581258
31Rough bone trabeculation (HP:0100670)2.84019461
32Carpal bone hypoplasia (HP:0001498)2.83969692
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.79528293
34Colon cancer (HP:0003003)2.77459619
35Increased serum pyruvate (HP:0003542)2.76202395
36Abnormality of glycolysis (HP:0004366)2.76202395
37Cerebral edema (HP:0002181)2.73793863
38White forelock (HP:0002211)2.73379647
39Abnormality of the preputium (HP:0100587)2.70975074
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.68737844
41Hypoplasia of the fovea (HP:0007750)2.68737844
42Abnormal gallbladder physiology (HP:0012438)2.68108968
43Cholecystitis (HP:0001082)2.68108968
44Meckel diverticulum (HP:0002245)2.67999587
45Progressive macrocephaly (HP:0004481)2.64598747
46Abnormality of methionine metabolism (HP:0010901)2.64581038
47CNS demyelination (HP:0007305)2.63551776
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63333522
49Respiratory failure (HP:0002878)2.62993876
50Adenoma sebaceum (HP:0009720)2.60849007
51Angiofibromas (HP:0010615)2.60849007
52Lactic acidosis (HP:0003128)2.56460676
53Abnormal hemoglobin (HP:0011902)2.55935586
54Leukodystrophy (HP:0002415)2.54900243
55Abnormality of reticulocytes (HP:0004312)2.54897697
56Secondary amenorrhea (HP:0000869)2.54795628
57Premature ovarian failure (HP:0008209)2.52571429
58Abnormality of the ileum (HP:0001549)2.51982903
59Hypokinesia (HP:0002375)2.51515963
60Hypobetalipoproteinemia (HP:0003563)2.48627926
61Emotional lability (HP:0000712)2.47386428
62Neoplasm of the adrenal gland (HP:0100631)2.37442555
63Increased hepatocellular lipid droplets (HP:0006565)2.35385164
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.35176632
65Abnormality of the fovea (HP:0000493)2.35031910
66Lipid accumulation in hepatocytes (HP:0006561)2.34663346
67Nausea (HP:0002018)2.34323911
68Optic disc pallor (HP:0000543)2.33926794
69Abnormal protein glycosylation (HP:0012346)2.33889166
70Abnormal glycosylation (HP:0012345)2.33889166
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33889166
72Abnormal protein N-linked glycosylation (HP:0012347)2.33889166
73Ependymoma (HP:0002888)2.33455467
74Cutaneous melanoma (HP:0012056)2.31634909
75Respiratory difficulties (HP:0002880)2.30304564
76Exercise intolerance (HP:0003546)2.29709389
77Increased intramyocellular lipid droplets (HP:0012240)2.26692883
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26491805
79Neoplasm of the pancreas (HP:0002894)2.26111945
80Abnormality of pyrimidine metabolism (HP:0004353)2.25776839
81Aplastic anemia (HP:0001915)2.24529851
82Megaloblastic anemia (HP:0001889)2.21536687
83Microvesicular hepatic steatosis (HP:0001414)2.20399612
84Hyperglycinemia (HP:0002154)2.20396188
85Sensory axonal neuropathy (HP:0003390)2.19708519
86Absent thumb (HP:0009777)2.19096885
87Lethargy (HP:0001254)2.17793778
88Pancytopenia (HP:0001876)2.15610009
89Aplasia/Hypoplasia of the macula (HP:0008059)2.15364591
90Ragged-red muscle fibers (HP:0003200)2.15217664
91Increased muscle lipid content (HP:0009058)2.15096022
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13899073
93Reduced antithrombin III activity (HP:0001976)2.13533037
94Selective tooth agenesis (HP:0001592)2.11709559
95Abnormality of chromosome stability (HP:0003220)2.10169774
96Horseshoe kidney (HP:0000085)2.10008786
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08838062
98Poor head control (HP:0002421)2.07668895
99Spastic paraparesis (HP:0002313)2.07230079
100Breast carcinoma (HP:0003002)2.04491808
101Rhabdomyolysis (HP:0003201)2.02776516
102Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98335886
103Abnormal trabecular bone morphology (HP:0100671)1.92943638
104Testicular atrophy (HP:0000029)1.92752659
105Abnormal cartilage morphology (HP:0002763)1.92457514
106Duodenal stenosis (HP:0100867)1.91924852
107Small intestinal stenosis (HP:0012848)1.91924852
108Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90416216
109Abnormality of the labia minora (HP:0012880)1.90347834
110CNS hypomyelination (HP:0003429)1.89768985
111Atrophy/Degeneration involving motor neurons (HP:0007373)1.89071742
112Hyperglycinuria (HP:0003108)1.88003471
113Sparse eyelashes (HP:0000653)1.87253930
114Abnormality of renal resorption (HP:0011038)1.87047126
115Abnormality of the umbilical cord (HP:0010881)1.86870319
116Achilles tendon contracture (HP:0001771)1.86785150
117Posterior subcapsular cataract (HP:0007787)1.86295444
118Glossoptosis (HP:0000162)1.85258861
119Patellar aplasia (HP:0006443)1.85255134
120Postnatal microcephaly (HP:0005484)1.84618110
121Conjunctival hamartoma (HP:0100780)1.84132033
122Hypoglycemic coma (HP:0001325)1.84122565
123Adrenal hypoplasia (HP:0000835)1.83766357
124Abnormality of serum amino acid levels (HP:0003112)1.83287600
1253-Methylglutaconic aciduria (HP:0003535)1.83219990
126Abnormality of the Achilles tendon (HP:0005109)1.83051545
127Aplasia/Hypoplasia of the patella (HP:0006498)1.82907022
128Congenital ichthyosiform erythroderma (HP:0007431)1.80511990
129Abnormal lung lobation (HP:0002101)1.80361201
130Cleft eyelid (HP:0000625)1.78845961
131Spastic diplegia (HP:0001264)1.78735652
132Increased serum ferritin (HP:0003281)1.77837351
133Aplasia/hypoplasia of the uterus (HP:0008684)1.76575510
134Albinism (HP:0001022)1.76346015
135Dicarboxylic aciduria (HP:0003215)1.76146516
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76146516
137Hyperammonemia (HP:0001987)1.75658005
138Myelodysplasia (HP:0002863)1.75478395
139Personality changes (HP:0000751)1.74897329
140Abnormality of alanine metabolism (HP:0010916)1.74467099
141Hyperalaninemia (HP:0003348)1.74467099
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74467099
143Exertional dyspnea (HP:0002875)1.74253717
144Cellular immunodeficiency (HP:0005374)1.71710914
145Delusions (HP:0000746)1.71396559
146Death in infancy (HP:0001522)1.70037910
147Overlapping toe (HP:0001845)1.68832765
148Premature graying of hair (HP:0002216)1.68444798
149Abnormality of glycine metabolism (HP:0010895)1.68318769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.20930593
2BUB14.79752979
3VRK24.47390356
4WEE13.47913629
5EIF2AK13.37889013
6TLK13.27682477
7TESK23.05247553
8TRIM282.98955338
9STK162.38457448
10BCKDK2.33689019
11SIK32.08200599
12CDC71.95235571
13MKNK21.90336487
14MAP3K111.89752602
15NUAK11.89511561
16TESK11.88938427
17EPHA21.86401351
18PDK21.80870279
19DYRK31.80661061
20SRPK11.80181213
21SCYL21.78042512
22MAP3K121.76652062
23RPS6KA41.75629378
24PASK1.75114544
25NEK11.75049534
26NEK21.72358204
27TAF11.71348149
28KDR1.56502489
29AURKA1.51312767
30NME11.50161342
31ACVR1B1.49645197
32PKN21.48211884
33TTK1.46090299
34PIM21.44480506
35EIF2AK31.43872532
36PAK41.42567327
37RPS6KB21.40570287
38PLK11.37285530
39MAP3K81.36941120
40BRAF1.32064601
41LIMK11.31436837
42LRRK21.31209716
43TRIB31.28918248
44AURKB1.25441861
45TSSK61.21451205
46VRK11.19830787
47PLK41.19368015
48ERBB31.18395854
49BLK1.16323122
50TGFBR11.12906402
51EIF2AK21.07869467
52ARAF1.04658929
53CDK71.02860324
54FLT31.02538985
55LATS21.02106361
56BRSK21.00524807
57SMG10.99912304
58DAPK10.97480728
59PAK10.97101503
60ERN10.96909249
61ABL20.96148392
62MAP3K100.95951084
63BCR0.91121315
64ILK0.88983726
65PLK20.86923494
66BMPR1B0.85533860
67MAPKAPK30.84123771
68CDK40.83108702
69IRAK30.82597437
70CCNB10.79124046
71MAP2K20.78492518
72CSNK1G10.77265685
73DAPK30.77180956
74PBK0.75288275
75PLK30.75191230
76CHEK20.73842746
77PRKCI0.71204458
78CSNK2A20.70543328
79DYRK20.69948720
80MAP2K30.69883268
81NEK90.69765980
82ZAP700.69292962
83BRSK10.65205118
84ZAK0.65104971
85ATR0.63192505
86CSNK2A10.62418647
87CSNK1G20.62028728
88STK40.61856963
89FER0.61365977
90RPS6KA50.60492342
91CSNK1A1L0.58313964
92PIM10.54477375
93ALK0.52789992
94EEF2K0.50838897
95CHEK10.50568801
96GRK60.50065493
97GRK10.45983067
98STK100.45886383
99MAP4K20.44917992
100CDK190.44178266
101MAPKAPK50.44041382
102ERBB40.43676725
103MST40.42181645
104WNK30.42170211
105STK30.41152175
106MKNK10.39890962
107ATM0.39773990
108CDK20.38637269
109MUSK0.38379102
110DYRK1B0.37351233
111TNIK0.37154553
112STK390.36043616
113PAK30.35968130
114PDK40.34379089
115PDK30.34379089
116MAP3K30.34020109
117CSNK1E0.32515567
118AKT20.32422985
119MAP4K10.31885120
120MST1R0.31685747
121MINK10.30054863
122CLK10.29545455
123TTN0.28767009
124MET0.28235010
125OXSR10.28226835
126MYLK0.28146415
127FGFR10.28142378
128CDK80.27528161
129MAP3K50.27516991
130CSNK1G30.26901863
131STK38L0.26434787
132FRK0.25737118
133CDK140.23654977
134MOS0.23437393
135PAK20.23420617
136MARK30.22814898
137RPS6KA10.22323286

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.37861439
2* Proteasome_Homo sapiens_hsa030504.33828070
3DNA replication_Homo sapiens_hsa030303.77111235
4RNA polymerase_Homo sapiens_hsa030203.09443028
5Mismatch repair_Homo sapiens_hsa034302.96815552
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77582370
7Spliceosome_Homo sapiens_hsa030402.72794597
8Pyrimidine metabolism_Homo sapiens_hsa002402.44096686
9RNA transport_Homo sapiens_hsa030132.40452883
10One carbon pool by folate_Homo sapiens_hsa006702.40392162
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33919769
12Sulfur relay system_Homo sapiens_hsa041222.21718434
13Parkinsons disease_Homo sapiens_hsa050122.13583818
14Oxidative phosphorylation_Homo sapiens_hsa001902.13184969
15Nucleotide excision repair_Homo sapiens_hsa034202.13164012
16Base excision repair_Homo sapiens_hsa034102.10334963
17Fatty acid elongation_Homo sapiens_hsa000621.94465499
18Folate biosynthesis_Homo sapiens_hsa007901.90956472
19Homologous recombination_Homo sapiens_hsa034401.87048901
20Protein export_Homo sapiens_hsa030601.74656458
21Huntingtons disease_Homo sapiens_hsa050161.63793598
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48048109
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46725383
24Cell cycle_Homo sapiens_hsa041101.41754724
25Carbon metabolism_Homo sapiens_hsa012001.36921756
26Biosynthesis of amino acids_Homo sapiens_hsa012301.36614632
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35246660
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34688655
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33711854
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.29947997
31Selenocompound metabolism_Homo sapiens_hsa004501.28893757
32Pentose phosphate pathway_Homo sapiens_hsa000301.20510185
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.17433165
34Alzheimers disease_Homo sapiens_hsa050101.16926915
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15058056
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.13289517
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08429946
38p53 signaling pathway_Homo sapiens_hsa041151.04634522
39Purine metabolism_Homo sapiens_hsa002301.03968664
40Systemic lupus erythematosus_Homo sapiens_hsa053220.99537683
41Basal transcription factors_Homo sapiens_hsa030220.99395098
42Glutathione metabolism_Homo sapiens_hsa004800.99198193
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96631200
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93822982
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91499326
46RNA degradation_Homo sapiens_hsa030180.88664536
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87856037
48Epstein-Barr virus infection_Homo sapiens_hsa051690.87788810
49Steroid biosynthesis_Homo sapiens_hsa001000.87650094
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82059769
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81393242
52mRNA surveillance pathway_Homo sapiens_hsa030150.80260051
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75228064
54Pyruvate metabolism_Homo sapiens_hsa006200.74780054
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74477770
56Non-homologous end-joining_Homo sapiens_hsa034500.73214458
57Fanconi anemia pathway_Homo sapiens_hsa034600.70950046
58Thyroid cancer_Homo sapiens_hsa052160.67734355
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63384718
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62923813
61Arginine and proline metabolism_Homo sapiens_hsa003300.62907393
62Galactose metabolism_Homo sapiens_hsa000520.61653980
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60852395
64Metabolic pathways_Homo sapiens_hsa011000.60061769
65Fructose and mannose metabolism_Homo sapiens_hsa000510.59274494
66Antigen processing and presentation_Homo sapiens_hsa046120.58142681
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56447802
68Bladder cancer_Homo sapiens_hsa052190.53461284
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52459409
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52278547
71Vibrio cholerae infection_Homo sapiens_hsa051100.51408409
72Legionellosis_Homo sapiens_hsa051340.50843313
73Vitamin B6 metabolism_Homo sapiens_hsa007500.50702214
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48684951
75Fatty acid degradation_Homo sapiens_hsa000710.48644467
76Collecting duct acid secretion_Homo sapiens_hsa049660.48111943
77Viral carcinogenesis_Homo sapiens_hsa052030.45871577
78Butanoate metabolism_Homo sapiens_hsa006500.45311971
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45215914
80Cardiac muscle contraction_Homo sapiens_hsa042600.44169081
81Fatty acid metabolism_Homo sapiens_hsa012120.43905854
82Fat digestion and absorption_Homo sapiens_hsa049750.43783299
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42089174
84Tyrosine metabolism_Homo sapiens_hsa003500.41703510
85Propanoate metabolism_Homo sapiens_hsa006400.41411342
86Phenylalanine metabolism_Homo sapiens_hsa003600.39973715
87Peroxisome_Homo sapiens_hsa041460.39243624
88Oocyte meiosis_Homo sapiens_hsa041140.37151956
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34322522
90N-Glycan biosynthesis_Homo sapiens_hsa005100.34314479
91Caffeine metabolism_Homo sapiens_hsa002320.33958272
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31481018
93Sulfur metabolism_Homo sapiens_hsa009200.30305411
94Herpes simplex infection_Homo sapiens_hsa051680.28220407
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27973363
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.27663724
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26835582
98beta-Alanine metabolism_Homo sapiens_hsa004100.26832458
99Alcoholism_Homo sapiens_hsa050340.26250371
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.26214613
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25806314
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.24499381
103Tryptophan metabolism_Homo sapiens_hsa003800.23774697
104Sphingolipid metabolism_Homo sapiens_hsa006000.23669075
105Shigellosis_Homo sapiens_hsa051310.23594913
106Apoptosis_Homo sapiens_hsa042100.23026057
107HTLV-I infection_Homo sapiens_hsa051660.22864820
108Chemical carcinogenesis_Homo sapiens_hsa052040.21935790
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21452969
110Arginine biosynthesis_Homo sapiens_hsa002200.21416371
111Regulation of autophagy_Homo sapiens_hsa041400.14727626
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12585071
113HIF-1 signaling pathway_Homo sapiens_hsa040660.11477596
114Prion diseases_Homo sapiens_hsa050200.11080139
115Vitamin digestion and absorption_Homo sapiens_hsa049770.09627485
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08961446
117Nitrogen metabolism_Homo sapiens_hsa009100.08927454
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08906081

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