PSMB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.78242311
2ATP synthesis coupled proton transport (GO:0015986)6.25569720
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.25569720
4ribosomal small subunit biogenesis (GO:0042274)5.99582636
5proteasome assembly (GO:0043248)5.64868101
6viral transcription (GO:0019083)5.56866786
7ribosomal small subunit assembly (GO:0000028)5.54791028
8translational termination (GO:0006415)5.42364797
9maturation of SSU-rRNA (GO:0030490)5.11837253
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.90349343
11cotranslational protein targeting to membrane (GO:0006613)4.89276420
12protein targeting to ER (GO:0045047)4.83555002
13* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.79672983
14translational elongation (GO:0006414)4.75725382
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.72108874
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.67937735
17ribosomal large subunit biogenesis (GO:0042273)4.62748606
18protein localization to endoplasmic reticulum (GO:0070972)4.62150200
19DNA deamination (GO:0045006)4.59447297
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.58768398
21respiratory electron transport chain (GO:0022904)4.48745882
22translational initiation (GO:0006413)4.45700580
23* regulation of cellular amino acid metabolic process (GO:0006521)4.44225446
24* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.43323220
25* negative regulation of ligase activity (GO:0051352)4.43323220
26termination of RNA polymerase III transcription (GO:0006386)4.43166367
27transcription elongation from RNA polymerase III promoter (GO:0006385)4.43166367
28* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.42080361
29protein neddylation (GO:0045116)4.40065693
30electron transport chain (GO:0022900)4.39590315
31cellular protein complex disassembly (GO:0043624)4.38565973
32viral life cycle (GO:0019058)4.36626210
33* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.33728313
34* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.31292765
35translation (GO:0006412)4.30434686
36chaperone-mediated protein transport (GO:0072321)4.30093182
37* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.25277473
38* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.25277473
39* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24663913
40cullin deneddylation (GO:0010388)4.24033489
41* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.22353471
42* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.22353471
43* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.22353471
44formation of translation preinitiation complex (GO:0001731)4.15973932
45* signal transduction involved in DNA damage checkpoint (GO:0072422)4.15722357
46* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.15722357
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.15188681
48establishment of integrated proviral latency (GO:0075713)4.12964073
49* signal transduction involved in cell cycle checkpoint (GO:0072395)4.10718864
50ribonucleoprotein complex biogenesis (GO:0022613)4.10156418
51* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.07747367
52protein deneddylation (GO:0000338)4.01714687
537-methylguanosine mRNA capping (GO:0006370)3.92269931
54RNA capping (GO:0036260)3.86569388
557-methylguanosine RNA capping (GO:0009452)3.86569388
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82116072
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.82116072
58NADH dehydrogenase complex assembly (GO:0010257)3.82116072
59* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.78889107
60* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.76837821
61rRNA modification (GO:0000154)3.76750128
62cellular component biogenesis (GO:0044085)3.75937303
63protein complex disassembly (GO:0043241)3.72449561
64establishment of protein localization to mitochondrion (GO:0072655)3.71859062
65rRNA processing (GO:0006364)3.71288013
66* negative regulation of protein ubiquitination (GO:0031397)3.69218127
67GTP biosynthetic process (GO:0006183)3.67536404
68oxidative phosphorylation (GO:0006119)3.65882056
69spliceosomal snRNP assembly (GO:0000387)3.65563223
70protein targeting to mitochondrion (GO:0006626)3.65210363
71protein complex biogenesis (GO:0070271)3.65055853
72respiratory chain complex IV assembly (GO:0008535)3.65051073
73* positive regulation of ligase activity (GO:0051351)3.63345351
74regulation of mitochondrial translation (GO:0070129)3.57111053
75establishment of viral latency (GO:0019043)3.56751318
76macromolecular complex disassembly (GO:0032984)3.56595484
77rRNA metabolic process (GO:0016072)3.55821542
78DNA strand elongation involved in DNA replication (GO:0006271)3.52973815
79cytochrome complex assembly (GO:0017004)3.51841161
80* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.50780421
81telomere maintenance via semi-conservative replication (GO:0032201)3.47166614
82* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.45961987
83pseudouridine synthesis (GO:0001522)3.45034242
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43863084
85UTP biosynthetic process (GO:0006228)3.43257418
86mitochondrial respiratory chain complex assembly (GO:0033108)3.42893039
87ribosome assembly (GO:0042255)3.41455082
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41051299
89* signal transduction in response to DNA damage (GO:0042770)3.38506725
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37616167
91transcription-coupled nucleotide-excision repair (GO:0006283)3.36700768
92* regulation of ubiquitin-protein transferase activity (GO:0051438)3.36433595
93protein localization to mitochondrion (GO:0070585)3.36217652
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35465482
95nucleobase biosynthetic process (GO:0046112)3.35155125
96* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.34317059
97* positive regulation of cell cycle arrest (GO:0071158)3.34302515
98spliceosomal complex assembly (GO:0000245)3.33942337
99DNA strand elongation (GO:0022616)3.33800042
100* regulation of cellular amine metabolic process (GO:0033238)3.32760408
101guanosine-containing compound biosynthetic process (GO:1901070)3.29549622
102* regulation of cell cycle arrest (GO:0071156)3.29364253
103* regulation of ligase activity (GO:0051340)3.26921132
104protein maturation by protein folding (GO:0022417)3.22897538
105purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21969365
106DNA replication initiation (GO:0006270)3.21689766
107transcription from RNA polymerase I promoter (GO:0006360)3.21323271
108ribosome biogenesis (GO:0042254)3.20712905
109* G1/S transition of mitotic cell cycle (GO:0000082)3.20285819
110* cell cycle G1/S phase transition (GO:0044843)3.20285819
111* negative regulation of cell cycle G1/S phase transition (GO:1902807)3.20250234
112* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.20250234
113purine nucleobase biosynthetic process (GO:0009113)3.20075053
114DNA catabolic process, exonucleolytic (GO:0000738)3.04230116
115deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04120663
116nucleobase-containing small molecule interconversion (GO:0015949)3.01614757
117inner mitochondrial membrane organization (GO:0007007)2.97087550
118* positive regulation of protein ubiquitination (GO:0031398)2.95451266
119nucleoside salvage (GO:0043174)2.91190657
120maturation of 5.8S rRNA (GO:0000460)2.90788073
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85744924
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85744924
123telomere maintenance via recombination (GO:0000722)2.82038119
124rRNA methylation (GO:0031167)2.80651089
125GDP-mannose metabolic process (GO:0019673)2.78369444
126mitochondrial transport (GO:0006839)2.78084758
127purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77597743
128pteridine-containing compound biosynthetic process (GO:0042559)2.73564684
129* positive regulation of protein modification by small protein conjugation or removal (GO:1903322)2.73379419
130DNA replication checkpoint (GO:0000076)2.73002022
131* regulation of G1/S transition of mitotic cell cycle (GO:2000045)2.71560282
132DNA double-strand break processing (GO:0000729)2.68442509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71319078
2E2F7_22180533_ChIP-Seq_HELA_Human4.47198009
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.38806596
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.30684403
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.26640545
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17602445
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.98533188
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92204040
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.77382844
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.72443565
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.55444110
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32610186
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31297348
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20159265
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.15577509
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06426319
17MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05045747
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90512299
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89765492
20VDR_23849224_ChIP-Seq_CD4+_Human2.63053290
21XRN2_22483619_ChIP-Seq_HELA_Human2.54131264
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53396217
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51827070
24DCP1A_22483619_ChIP-Seq_HELA_Human2.42247182
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40574542
26* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34977214
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.27658085
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24937826
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.24582742
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24055505
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16220223
32FOXP3_21729870_ChIP-Seq_TREG_Human2.13263256
33TTF2_22483619_ChIP-Seq_HELA_Human2.06115879
34* ELK1_19687146_ChIP-ChIP_HELA_Human2.02178731
35GABP_19822575_ChIP-Seq_HepG2_Human2.00289294
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.96909504
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86712743
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78815978
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75473084
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64899613
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59949636
42* ELK1_22589737_ChIP-Seq_MCF10A_Human1.56301981
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54218480
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53204593
45* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51479900
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50066244
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49004333
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45904193
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45755599
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45609711
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.45431211
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36711517
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34748436
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33399190
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30551819
56* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25696553
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24650598
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24241149
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22623135
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21674910
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20708904
62AR_21909140_ChIP-Seq_LNCAP_Human1.19873447
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19713234
64* MYC_18940864_ChIP-ChIP_HL60_Human1.18093693
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17704524
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17364586
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16001312
68* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14252242
69KDM5A_27292631_Chip-Seq_BREAST_Human1.14113904
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11165878
71IRF1_19129219_ChIP-ChIP_H3396_Human1.10145431
72CIITA_25753668_ChIP-Seq_RAJI_Human1.08662282
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06860718
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01504294
75* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00466446
76* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98966069
77SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98116470
78E2F1_21310950_ChIP-Seq_MCF-7_Human0.97279369
79ELF5_23300383_ChIP-Seq_T47D_Human0.95405977
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95266134
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93624259
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92356408
83* SPI1_23547873_ChIP-Seq_NB4_Human0.91856860
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91573861
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90906271
86* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89236284
87* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89002861
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88735358
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88588501
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88436543
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86487269
92* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86034450
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85942186
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85309356
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85289058
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83763985
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.83747954
98BP1_19119308_ChIP-ChIP_Hs578T_Human0.82822657
99* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82207816
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81843027
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81795450
102* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81223924
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80512284
104IRF8_21731497_ChIP-ChIP_J774_Mouse0.79936932
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79737943
106TFEB_21752829_ChIP-Seq_HELA_Human0.78752087
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78202350
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78166358
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78028319
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.76824144
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75501043
112NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75229451
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75173159
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73604020
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73604020
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.71191639
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70513957
118ZNF263_19887448_ChIP-Seq_K562_Human0.69701050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06487653
2MP0004957_abnormal_blastocyst_morpholog4.54377602
3MP0009379_abnormal_foot_pigmentation4.04731576
4MP0003806_abnormal_nucleotide_metabolis3.96086764
5MP0010094_abnormal_chromosome_stability3.28782806
6MP0003077_abnormal_cell_cycle3.21668534
7MP0008932_abnormal_embryonic_tissue3.15327345
8MP0008057_abnormal_DNA_replication3.12536271
9MP0003111_abnormal_nucleus_morphology3.07403071
10MP0001529_abnormal_vocalization3.02438278
11MP0003718_maternal_effect2.88483479
12MP0008058_abnormal_DNA_repair2.80189979
13MP0003186_abnormal_redox_activity2.67856487
14MP0009697_abnormal_copulation2.55094752
15MP0003786_premature_aging2.52875206
16MP0001905_abnormal_dopamine_level2.44011006
17MP0006035_abnormal_mitochondrial_morpho2.28980203
18MP0006036_abnormal_mitochondrial_physio2.28476095
19MP0003136_yellow_coat_color2.18517522
20MP0008007_abnormal_cellular_replicative2.06452245
21MP0008875_abnormal_xenobiotic_pharmacok2.02697539
22MP0003315_abnormal_perineum_morphology1.94214997
23MP0005671_abnormal_response_to1.69423772
24MP0000372_irregular_coat_pigmentation1.62152039
25MP0001730_embryonic_growth_arrest1.60508546
26MP0009333_abnormal_splenocyte_physiolog1.58637501
27MP0003123_paternal_imprinting1.58548978
28MP0005408_hypopigmentation1.57474235
29MP0002132_abnormal_respiratory_system1.56652790
30MP0005075_abnormal_melanosome_morpholog1.53608449
31MP0001727_abnormal_embryo_implantation1.50737063
32MP0001835_abnormal_antigen_presentation1.49693782
33MP0008995_early_reproductive_senescence1.49279538
34MP0003191_abnormal_cellular_cholesterol1.41839592
35MP0004133_heterotaxia1.41756400
36MP0006292_abnormal_olfactory_placode1.39674760
37MP0003195_calcinosis1.37316451
38MP0000350_abnormal_cell_proliferation1.35854003
39MP0003011_delayed_dark_adaptation1.32836409
40MP0005084_abnormal_gallbladder_morpholo1.32148907
41MP0000358_abnormal_cell_content/1.30504452
42MP0004381_abnormal_hair_follicle1.29576265
43MP0006276_abnormal_autonomic_nervous1.24728387
44MP0005645_abnormal_hypothalamus_physiol1.20924044
45MP0002751_abnormal_autonomic_nervous1.19990273
46MP0002938_white_spotting1.19917407
47MP0004142_abnormal_muscle_tone1.19225146
48MP0002163_abnormal_gland_morphology1.16029789
49MP0002837_dystrophic_cardiac_calcinosis1.15885730
50MP0005266_abnormal_metabolism1.14338476
51MP0001542_abnormal_bone_strength1.12300382
52MP0005332_abnormal_amino_acid1.11169387
53MP0000313_abnormal_cell_death1.08608301
54MP0001881_abnormal_mammary_gland1.08522235
55MP0008789_abnormal_olfactory_epithelium1.05644374
56MP0005379_endocrine/exocrine_gland_phen1.04622024
57MP0001764_abnormal_homeostasis1.03573242
58MP0002160_abnormal_reproductive_system1.03236019
59MP0002166_altered_tumor_susceptibility1.00989457
60MP0000490_abnormal_crypts_of1.00958950
61MP0008260_abnormal_autophagy1.00712540
62MP0002638_abnormal_pupillary_reflex0.99585441
63MP0003880_abnormal_central_pattern0.99226237
64MP0002006_tumorigenesis0.98680391
65MP0002080_prenatal_lethality0.98024289
66MP0005319_abnormal_enzyme/_coenzyme0.97876487
67MP0005451_abnormal_body_composition0.97338208
68MP0006072_abnormal_retinal_apoptosis0.97098817
69MP0010307_abnormal_tumor_latency0.96836161
70MP0001697_abnormal_embryo_size0.95664972
71MP0001853_heart_inflammation0.95300339
72MP0000015_abnormal_ear_pigmentation0.94408238
73MP0010030_abnormal_orbit_morphology0.94305148
74MP0006082_CNS_inflammation0.92897083
75MP0005646_abnormal_pituitary_gland0.92789784
76MP0001873_stomach_inflammation0.92595719
77MP0005025_abnormal_response_to0.92228456
78MP0002254_reproductive_system_inflammat0.90978502
79MP0008877_abnormal_DNA_methylation0.90830688
80MP0005410_abnormal_fertilization0.90700884
81MP0000750_abnormal_muscle_regeneration0.90427365
82MP0005330_cardiomyopathy0.87538457
83MP0005000_abnormal_immune_tolerance0.86919812
84MP0005584_abnormal_enzyme/coenzyme_acti0.86617026
85MP0002090_abnormal_vision0.85861047
86MP0002102_abnormal_ear_morphology0.85396457
87MP0008469_abnormal_protein_level0.85352008
88MP0002282_abnormal_trachea_morphology0.85252394
89MP0000343_altered_response_to0.85238637
90MP0006054_spinal_hemorrhage0.84906473
91MP0001845_abnormal_inflammatory_respons0.84863965
92MP0005083_abnormal_biliary_tract0.84656176
93MP0002277_abnormal_respiratory_mucosa0.84419370
94MP0005058_abnormal_lysosome_morphology0.83060309
95MP0005389_reproductive_system_phenotype0.81710043
96MP0002019_abnormal_tumor_incidence0.81055662
97MP0001986_abnormal_taste_sensitivity0.78843825
98MP0002736_abnormal_nociception_after0.78199117
99MP0001661_extended_life_span0.78020810
100MP0005165_increased_susceptibility_to0.77901053
101MP0002420_abnormal_adaptive_immunity0.77599108
102MP0003567_abnormal_fetal_cardiomyocyte0.76766425
103MP0001819_abnormal_immune_cell0.76299097
104MP0002452_abnormal_antigen_presenting0.75048015
105MP0004147_increased_porphyrin_level0.75018417
106MP0005376_homeostasis/metabolism_phenot0.74889964
107MP0003938_abnormal_ear_development0.74531297
108MP0000685_abnormal_immune_system0.74499712
109MP0001790_abnormal_immune_system0.74331036
110MP0005387_immune_system_phenotype0.74331036
111MP0002095_abnormal_skin_pigmentation0.73760612
112MP0001672_abnormal_embryogenesis/_devel0.73497173
113MP0005380_embryogenesis_phenotype0.73497173
114MP0002723_abnormal_immune_serum0.73082956
115MP0002139_abnormal_hepatobiliary_system0.72899195
116MP0002085_abnormal_embryonic_tissue0.71854082
117MP0001929_abnormal_gametogenesis0.71465717
118MP0005499_abnormal_olfactory_system0.71176549
119MP0005394_taste/olfaction_phenotype0.71176549
120MP0001485_abnormal_pinna_reflex0.70276154
121MP0002398_abnormal_bone_marrow0.70205232
122MP0002877_abnormal_melanocyte_morpholog0.69689485
123MP0002148_abnormal_hypersensitivity_rea0.69628487
124MP0002210_abnormal_sex_determination0.69192338
125MP0000647_abnormal_sebaceous_gland0.68440676
126MP0000762_abnormal_tongue_morphology0.68385647
127MP0002396_abnormal_hematopoietic_system0.67538931
128MP0000516_abnormal_urinary_system0.67521845
129MP0005367_renal/urinary_system_phenotyp0.67521845
130MP0003950_abnormal_plasma_membrane0.67444030
131MP0009763_increased_sensitivity_to0.67267015
132MP0005395_other_phenotype0.67189765
133MP0005171_absent_coat_pigmentation0.65844783
134MP0002332_abnormal_exercise_endurance0.65835950
135MP0000049_abnormal_middle_ear0.65658317
136MP0002722_abnormal_immune_system0.64883154
137MP0001145_abnormal_male_reproductive0.64078877
138MP0000689_abnormal_spleen_morphology0.63030342
139MP0005409_darkened_coat_color0.60613130
140MP0005636_abnormal_mineral_homeostasis0.60453295
141MP0003763_abnormal_thymus_physiology0.59631889
142MP0002653_abnormal_ependyma_morphology0.58259312
143MP0003984_embryonic_growth_retardation0.57591012
144MP0008873_increased_physiological_sensi0.57039491
145MP0000749_muscle_degeneration0.54651200
146MP0002088_abnormal_embryonic_growth/wei0.54630943
147MP0000858_altered_metastatic_potential0.53411839
148MP0009785_altered_susceptibility_to0.52458666
149MP0000703_abnormal_thymus_morphology0.51241985
150MP0003890_abnormal_embryonic-extraembry0.50917671
151MP0002429_abnormal_blood_cell0.50829806
152MP0008872_abnormal_physiological_respon0.50554953
153MP0001919_abnormal_reproductive_system0.49787801

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.83361391
2Mitochondrial inheritance (HP:0001427)5.40567761
3Abnormal mitochondria in muscle tissue (HP:0008316)5.25095933
4Abnormality of cells of the erythroid lineage (HP:0012130)5.22053628
5Hepatocellular necrosis (HP:0001404)4.84856061
6Increased CSF lactate (HP:0002490)4.78695140
7Abnormal number of erythroid precursors (HP:0012131)4.70711101
8Acute encephalopathy (HP:0006846)4.67379457
9Progressive macrocephaly (HP:0004481)4.65953804
10Increased hepatocellular lipid droplets (HP:0006565)4.63535513
11Increased serum pyruvate (HP:0003542)4.38853142
12Abnormality of glycolysis (HP:0004366)4.38853142
13Reticulocytopenia (HP:0001896)4.28670415
14Hepatic necrosis (HP:0002605)4.26895448
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.23011833
163-Methylglutaconic aciduria (HP:0003535)4.13060738
17Lipid accumulation in hepatocytes (HP:0006561)4.06186539
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.00221416
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91432998
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91432998
21Macrocytic anemia (HP:0001972)3.78672570
22Renal Fanconi syndrome (HP:0001994)3.76201330
23Increased serum lactate (HP:0002151)3.65658644
24Cerebral hypomyelination (HP:0006808)3.59658631
25Respiratory failure (HP:0002878)3.39333400
26Exercise intolerance (HP:0003546)3.37765137
27Cerebral edema (HP:0002181)3.27759984
28Increased intramyocellular lipid droplets (HP:0012240)3.27753881
29Birth length less than 3rd percentile (HP:0003561)3.26017037
30Exertional dyspnea (HP:0002875)3.25341897
31Breast hypoplasia (HP:0003187)3.21443561
32Lactic acidosis (HP:0003128)3.12878431
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.11702786
34Abnormal protein N-linked glycosylation (HP:0012347)3.11702786
35Abnormal protein glycosylation (HP:0012346)3.11702786
36Abnormal glycosylation (HP:0012345)3.11702786
37Leukodystrophy (HP:0002415)3.07455397
38Pallor (HP:0000980)3.06242479
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.04440995
40Respiratory difficulties (HP:0002880)2.87055273
41Parakeratosis (HP:0001036)2.80105638
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78216264
43Reduced antithrombin III activity (HP:0001976)2.77987986
44Optic disc pallor (HP:0000543)2.71446649
45Increased muscle lipid content (HP:0009058)2.67606650
46Oral leukoplakia (HP:0002745)2.67076225
47Carpal bone hypoplasia (HP:0001498)2.58889262
48Microvesicular hepatic steatosis (HP:0001414)2.57104794
49Abnormal gallbladder physiology (HP:0012438)2.56957872
50Cholecystitis (HP:0001082)2.56957872
51Rough bone trabeculation (HP:0100670)2.56184975
52CNS demyelination (HP:0007305)2.55571209
53Multiple enchondromatosis (HP:0005701)2.52793515
54Emotional lability (HP:0000712)2.47453352
55Congenital ichthyosiform erythroderma (HP:0007431)2.43716980
56Abnormality of methionine metabolism (HP:0010901)2.38853791
57Aplastic anemia (HP:0001915)2.38538055
58Type I transferrin isoform profile (HP:0003642)2.37045963
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35598687
60Generalized aminoaciduria (HP:0002909)2.32081239
61Methylmalonic aciduria (HP:0012120)2.30503259
62Hypokinesia (HP:0002375)2.20667325
63Secondary amenorrhea (HP:0000869)2.20499690
64Trismus (HP:0000211)2.18566802
65Abnormality of renal resorption (HP:0011038)2.17655624
66Abnormality of placental membranes (HP:0011409)2.15491176
67Amniotic constriction ring (HP:0009775)2.15491176
68Nausea (HP:0002018)2.12134604
69Dicarboxylic aciduria (HP:0003215)2.11595740
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11595740
71Abnormality of the preputium (HP:0100587)2.07442940
72Neuroendocrine neoplasm (HP:0100634)2.06157852
73CNS hypomyelination (HP:0003429)2.05382556
74Microretrognathia (HP:0000308)2.02068638
75Sparse eyelashes (HP:0000653)1.97414250
76Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96713454
77Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96303461
78Patellar aplasia (HP:0006443)1.95501339
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95261287
80Opisthotonus (HP:0002179)1.95189383
81Irregular epiphyses (HP:0010582)1.94980343
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91962809
83Premature graying of hair (HP:0002216)1.91854229
84Abnormal trabecular bone morphology (HP:0100671)1.91759087
85Methylmalonic acidemia (HP:0002912)1.90360953
86X-linked dominant inheritance (HP:0001423)1.90230870
87Lethargy (HP:0001254)1.89142151
88Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88239750
89Stenosis of the external auditory canal (HP:0000402)1.87824328
90Aplasia/Hypoplasia of the patella (HP:0006498)1.87366720
91Poor head control (HP:0002421)1.86942597
92Ragged-red muscle fibers (HP:0003200)1.85752955
93Testicular atrophy (HP:0000029)1.85564037
94Abnormality of the axillary hair (HP:0100134)1.85468826
95Abnormality of secondary sexual hair (HP:0009888)1.85468826
96Absent radius (HP:0003974)1.85251350
97Delusions (HP:0000746)1.85215138
98Aplasia/hypoplasia of the uterus (HP:0008684)1.85035812
99Palpitations (HP:0001962)1.84792451
100Horseshoe kidney (HP:0000085)1.84539707
101Abnormality of the anterior horn cell (HP:0006802)1.82423165
102Degeneration of anterior horn cells (HP:0002398)1.82423165
103Glycosuria (HP:0003076)1.82301115
104Abnormality of urine glucose concentration (HP:0011016)1.82301115
105Petechiae (HP:0000967)1.82169766
106Glossoptosis (HP:0000162)1.82044763
107Premature ovarian failure (HP:0008209)1.79937971
108Absent thumb (HP:0009777)1.79006987
109Abnormality of the ileum (HP:0001549)1.78866982
110Posterior subcapsular cataract (HP:0007787)1.77785215
111Pancytopenia (HP:0001876)1.77526341
112Hyperalaninemia (HP:0003348)1.77194311
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77194311
114Abnormality of alanine metabolism (HP:0010916)1.77194311
115Cleft eyelid (HP:0000625)1.77160299
116Congenital, generalized hypertrichosis (HP:0004540)1.75990713
117Cellular immunodeficiency (HP:0005374)1.74907033
118IgM deficiency (HP:0002850)1.74485552
119Aplasia involving forearm bones (HP:0009822)1.73638394
120Absent forearm bone (HP:0003953)1.73638394
121Progressive external ophthalmoplegia (HP:0000590)1.73236686
122Hyperphosphaturia (HP:0003109)1.73217487
123Neoplasm of the adrenal gland (HP:0100631)1.71336165
124Abnormality of the umbilical cord (HP:0010881)1.70440806
125Hepatosplenomegaly (HP:0001433)1.69619480
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.69240791
12711 pairs of ribs (HP:0000878)1.68971627
128Postnatal microcephaly (HP:0005484)1.68763540
129Gliosis (HP:0002171)1.68009214
130Abnormality of serum amino acid levels (HP:0003112)1.67521013
131Spastic paraparesis (HP:0002313)1.66996317
132Blindness (HP:0000618)1.66342799
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65561085
134Vomiting (HP:0002013)1.65376947
135Meckel diverticulum (HP:0002245)1.65242484
136Triphalangeal thumb (HP:0001199)1.64482528
137Progressive microcephaly (HP:0000253)1.64086142
138Abnormality of the fetal cardiovascular system (HP:0010948)1.63983779
139Single umbilical artery (HP:0001195)1.63983779
140Abnormal pupillary function (HP:0007686)1.62694582
141Neutropenia (HP:0001875)1.61739585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.21914581
2VRK24.60027047
3STK163.72360077
4NME23.58383396
5WEE13.57084740
6EIF2AK12.95306089
7NME12.87125859
8TESK22.81080055
9SRPK12.64583154
10TSSK62.56472133
11VRK12.53197093
12PBK2.30661161
13EIF2AK32.16926172
14MST42.07035495
15TLK11.98137676
16PIM21.95004355
17PLK41.89817779
18ARAF1.85893139
19PNCK1.65830098
20LIMK11.63987027
21PDK21.61315352
22NUAK11.55860290
23MAP3K121.55584650
24KDR1.47377248
25EPHA21.46217777
26CDC71.42981670
27TRIM281.38190088
28AURKA1.34209467
29RPS6KB21.32932267
30TESK11.30115335
31PLK11.26242541
32MYLK1.24235236
33SCYL21.23806567
34PLK31.22155197
35MST1R1.21254293
36TTK1.17873242
37TXK1.17465269
38MAP4K21.16214497
39DYRK21.15850603
40BRAF1.14526254
41ZAK1.09633604
42AURKB1.03983483
43ABL21.01853651
44BCR1.00594942
45BRSK20.99274076
46ACVR1B0.96213223
47NEK10.93569913
48GRK50.92338839
49MKNK10.91078005
50STK240.89632920
51ILK0.89038473
52CDK70.88951921
53CDK190.86831632
54BCKDK0.85604373
55PAK10.83611499
56GRK70.83007411
57CCNB10.82672161
58ADRBK20.81879475
59MAP3K110.81268509
60GRK60.80829313
61CSNK1A1L0.80467693
62BMPR1B0.79213639
63TAF10.77676450
64CSNK2A20.76512239
65CSNK2A10.76259178
66BLK0.76160023
67DYRK30.74432504
68CHEK20.73666163
69INSRR0.73142185
70STK390.70779911
71EIF2AK20.70139671
72PAK40.68168173
73OBSCN0.67613502
74LRRK20.66712217
75BRSK10.66541075
76SIK30.63279176
77MAPKAPK30.63160945
78CSNK1G20.63114319
79CASK0.62753800
80PRKCI0.61425801
81RPS6KA50.61189747
82CSNK1G30.60362449
83ATR0.59070286
84PASK0.58901264
85GRK10.57634791
86MUSK0.57617632
87CDK80.57405734
88ERBB30.56869029
89OXSR10.55890180
90MAP3K80.52123616
91DAPK30.50949835
92IKBKB0.46127095
93CLK10.43546110
94MAPKAPK50.42506454
95AKT30.41886950
96IRAK30.40618917
97ADRBK10.40188787
98CHEK10.40081393
99MKNK20.39284722
100DAPK10.39019359
101CAMK2B0.37936640
102CDK140.36832718
103WNK30.36790187
104RPS6KA40.36316364
105PIM10.36268226
106YES10.35886486
107STK40.35052299
108CDK11A0.34906093
109CDK180.34739540
110FER0.33656849
111MAP3K30.33066230
112CDK150.32970234
113TBK10.31606793
114ALK0.31247270
115TGFBR10.29890939
116PIK3CG0.29869359
117IRAK40.26597280
118TAOK20.26521694
119ROCK20.26515492
120BMPR20.26030843
121CAMK2G0.25900473
122NEK20.25765802
123PLK20.24973835
124CSNK1G10.24638823
125LYN0.24615094
126STK100.24330592
127PRKCQ0.23007629

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.26756451
2Ribosome_Homo sapiens_hsa030105.08672710
3Oxidative phosphorylation_Homo sapiens_hsa001904.16612868
4RNA polymerase_Homo sapiens_hsa030203.83659723
5Parkinsons disease_Homo sapiens_hsa050123.64837979
6DNA replication_Homo sapiens_hsa030303.07321092
7Huntingtons disease_Homo sapiens_hsa050162.74240086
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71260087
9Mismatch repair_Homo sapiens_hsa034302.67292857
10Spliceosome_Homo sapiens_hsa030402.52430120
11Alzheimers disease_Homo sapiens_hsa050102.48827473
12Pyrimidine metabolism_Homo sapiens_hsa002402.47843050
13Protein export_Homo sapiens_hsa030602.22441627
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16109832
15Nucleotide excision repair_Homo sapiens_hsa034202.12840676
16Homologous recombination_Homo sapiens_hsa034402.10928371
17RNA transport_Homo sapiens_hsa030131.90008397
18Base excision repair_Homo sapiens_hsa034101.72052437
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60684681
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59186948
21Basal transcription factors_Homo sapiens_hsa030221.44776525
22One carbon pool by folate_Homo sapiens_hsa006701.40403047
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35099234
24Non-homologous end-joining_Homo sapiens_hsa034501.32451938
25Purine metabolism_Homo sapiens_hsa002301.31230684
26RNA degradation_Homo sapiens_hsa030181.31167991
27Cardiac muscle contraction_Homo sapiens_hsa042601.23387346
28Fanconi anemia pathway_Homo sapiens_hsa034601.22281140
29Cell cycle_Homo sapiens_hsa041101.15843135
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12960462
31Glutathione metabolism_Homo sapiens_hsa004801.11498062
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05341696
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04029253
34Fatty acid elongation_Homo sapiens_hsa000620.95693937
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92348583
36Epstein-Barr virus infection_Homo sapiens_hsa051690.91441724
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88884434
38Folate biosynthesis_Homo sapiens_hsa007900.87361910
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85593146
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.84140944
41Vitamin B6 metabolism_Homo sapiens_hsa007500.80991801
42Collecting duct acid secretion_Homo sapiens_hsa049660.80661838
43Pentose phosphate pathway_Homo sapiens_hsa000300.80334124
44Metabolic pathways_Homo sapiens_hsa011000.77205377
45Steroid biosynthesis_Homo sapiens_hsa001000.74756736
46Arachidonic acid metabolism_Homo sapiens_hsa005900.74047025
47Systemic lupus erythematosus_Homo sapiens_hsa053220.71956652
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67776491
49Sulfur relay system_Homo sapiens_hsa041220.67751937
50Carbon metabolism_Homo sapiens_hsa012000.67670269
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66617316
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.65687450
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65031128
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64483644
55p53 signaling pathway_Homo sapiens_hsa041150.63540987
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61771835
57Biosynthesis of amino acids_Homo sapiens_hsa012300.61529180
58Pyruvate metabolism_Homo sapiens_hsa006200.60534044
59Phenylalanine metabolism_Homo sapiens_hsa003600.58599541
60Tyrosine metabolism_Homo sapiens_hsa003500.57898942
61Caffeine metabolism_Homo sapiens_hsa002320.57827495
62Fructose and mannose metabolism_Homo sapiens_hsa000510.55649809
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55107577
64Linoleic acid metabolism_Homo sapiens_hsa005910.53490906
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52767521
66mRNA surveillance pathway_Homo sapiens_hsa030150.52057416
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51364097
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.51049238
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.50119527
70Regulation of autophagy_Homo sapiens_hsa041400.49825700
71Vibrio cholerae infection_Homo sapiens_hsa051100.48834740
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44448080
73Graft-versus-host disease_Homo sapiens_hsa053320.44000174
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43809772
75Tryptophan metabolism_Homo sapiens_hsa003800.43805889
76Arginine and proline metabolism_Homo sapiens_hsa003300.43355113
77Selenocompound metabolism_Homo sapiens_hsa004500.43349167
78Fatty acid metabolism_Homo sapiens_hsa012120.43128773
79Sulfur metabolism_Homo sapiens_hsa009200.40478552
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40276743
81Butanoate metabolism_Homo sapiens_hsa006500.39153291
82Ether lipid metabolism_Homo sapiens_hsa005650.38595995
83Type I diabetes mellitus_Homo sapiens_hsa049400.37166612
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36343932
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35346714
86Fatty acid degradation_Homo sapiens_hsa000710.34879487
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33201647
88Antigen processing and presentation_Homo sapiens_hsa046120.33145889
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30213050
90Primary immunodeficiency_Homo sapiens_hsa053400.30049486
91Allograft rejection_Homo sapiens_hsa053300.29967186
92Rheumatoid arthritis_Homo sapiens_hsa053230.29780540
93Chemical carcinogenesis_Homo sapiens_hsa052040.26270401
94Autoimmune thyroid disease_Homo sapiens_hsa053200.26059999
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25974786
96Oocyte meiosis_Homo sapiens_hsa041140.25113412
97beta-Alanine metabolism_Homo sapiens_hsa004100.23948779
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23716692
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.23428481
100Asthma_Homo sapiens_hsa053100.22832013
101Histidine metabolism_Homo sapiens_hsa003400.22276403
102Galactose metabolism_Homo sapiens_hsa000520.20324731
103Phagosome_Homo sapiens_hsa041450.20260533
104Alcoholism_Homo sapiens_hsa050340.20195807
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19862157
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19800094
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16772100
108Viral carcinogenesis_Homo sapiens_hsa052030.16661087
109Legionellosis_Homo sapiens_hsa051340.15195182
110Peroxisome_Homo sapiens_hsa041460.12624332
111Sphingolipid metabolism_Homo sapiens_hsa006000.11465403
112N-Glycan biosynthesis_Homo sapiens_hsa005100.09525433
113Shigellosis_Homo sapiens_hsa051310.06789612
114Propanoate metabolism_Homo sapiens_hsa006400.06705399
115Herpes simplex infection_Homo sapiens_hsa051680.06634108
116Other glycan degradation_Homo sapiens_hsa005110.05191902
117Renin-angiotensin system_Homo sapiens_hsa046140.03506303

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