PSMA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.18364215
2ribosomal small subunit assembly (GO:0000028)4.94576740
3formation of translation preinitiation complex (GO:0001731)4.93399768
4proteasome assembly (GO:0043248)4.83214844
5ribosomal small subunit biogenesis (GO:0042274)4.54165615
6viral transcription (GO:0019083)4.50277946
7* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.49815736
8translational termination (GO:0006415)4.47941974
9ribosomal large subunit biogenesis (GO:0042273)4.42209581
10nucleobase biosynthetic process (GO:0046112)4.36577719
11purine nucleobase biosynthetic process (GO:0009113)4.33935600
12chaperone-mediated protein transport (GO:0072321)4.31852277
13* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.28177138
14DNA strand elongation involved in DNA replication (GO:0006271)4.28137673
15* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.19308651
16* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.12356874
17* regulation of cellular amino acid metabolic process (GO:0006521)4.11349045
18translational initiation (GO:0006413)4.07464765
19DNA strand elongation (GO:0022616)4.06900146
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06774908
21translational elongation (GO:0006414)4.06127505
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06090814
23* negative regulation of ligase activity (GO:0051352)4.04738384
24* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.04738384
25respiratory electron transport chain (GO:0022904)4.03057295
26telomere maintenance via semi-conservative replication (GO:0032201)4.00634881
27ribonucleoprotein complex biogenesis (GO:0022613)3.98421658
28* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.97278758
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95637141
30electron transport chain (GO:0022900)3.92549755
31* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.90550195
32* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.90550195
33cotranslational protein targeting to membrane (GO:0006613)3.90047446
34ribosome assembly (GO:0042255)3.89651958
35DNA replication initiation (GO:0006270)3.88299521
36* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.87219479
37* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.87219479
38* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.87219479
39protein targeting to ER (GO:0045047)3.86274636
40establishment of viral latency (GO:0019043)3.85902095
41* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.84298502
42DNA replication checkpoint (GO:0000076)3.83843669
43cullin deneddylation (GO:0010388)3.82357510
44protein neddylation (GO:0045116)3.81013996
45* signal transduction involved in DNA damage checkpoint (GO:0072422)3.80752724
46* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.80752724
47CENP-A containing nucleosome assembly (GO:0034080)3.79101430
48* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.75606350
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74563134
50ATP synthesis coupled proton transport (GO:0015986)3.74563134
51* signal transduction involved in cell cycle checkpoint (GO:0072395)3.74380530
52DNA ligation (GO:0006266)3.70598350
53regulation of mitochondrial translation (GO:0070129)3.69421803
54protein localization to endoplasmic reticulum (GO:0070972)3.68509693
55telomere maintenance via recombination (GO:0000722)3.68153134
56translation (GO:0006412)3.67075839
57chromatin remodeling at centromere (GO:0031055)3.66927510
58ribosome biogenesis (GO:0042254)3.65451765
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65357026
60DNA deamination (GO:0045006)3.64406154
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62659083
62* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.62638622
63protein deneddylation (GO:0000338)3.62363748
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60938581
65rRNA processing (GO:0006364)3.59780499
66* positive regulation of ligase activity (GO:0051351)3.58814598
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58285977
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.57107225
69spliceosomal snRNP assembly (GO:0000387)3.57040527
70DNA unwinding involved in DNA replication (GO:0006268)3.57013690
71viral life cycle (GO:0019058)3.55735154
72cellular protein complex disassembly (GO:0043624)3.52550693
73DNA damage response, detection of DNA damage (GO:0042769)3.50420390
74mitochondrial respiratory chain complex assembly (GO:0033108)3.48235835
75establishment of integrated proviral latency (GO:0075713)3.48158326
76termination of RNA polymerase III transcription (GO:0006386)3.47805300
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.47805300
78rRNA metabolic process (GO:0016072)3.46039730
79pseudouridine synthesis (GO:0001522)3.44657565
80rRNA modification (GO:0000154)3.44608960
81protein complex biogenesis (GO:0070271)3.43818491
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43395987
83regulation of mitotic spindle checkpoint (GO:1903504)3.43395987
84mitotic metaphase plate congression (GO:0007080)3.41467867
85mitotic recombination (GO:0006312)3.40653964
86* cell cycle G1/S phase transition (GO:0044843)3.39204704
87* G1/S transition of mitotic cell cycle (GO:0000082)3.39204704
88DNA double-strand break processing (GO:0000729)3.37358673
897-methylguanosine mRNA capping (GO:0006370)3.37093606
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.35775511
91NADH dehydrogenase complex assembly (GO:0010257)3.35775511
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35775511
93cellular component biogenesis (GO:0044085)3.34797808
94folic acid metabolic process (GO:0046655)3.34685836
957-methylguanosine RNA capping (GO:0009452)3.32429738
96RNA capping (GO:0036260)3.32429738
97transcription-coupled nucleotide-excision repair (GO:0006283)3.30520083
98metaphase plate congression (GO:0051310)3.28457132
99spindle checkpoint (GO:0031577)3.28267534
100* regulation of ubiquitin-protein transferase activity (GO:0051438)3.26790995
101DNA replication-independent nucleosome organization (GO:0034724)3.25637015
102DNA replication-independent nucleosome assembly (GO:0006336)3.25637015
103mitotic sister chromatid segregation (GO:0000070)3.24078255
104telomere maintenance via telomere lengthening (GO:0010833)3.22698412
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.20603628
106regulation of helicase activity (GO:0051095)3.19711690
107negative regulation of mitotic sister chromatid separation (GO:2000816)3.19088047
108negative regulation of sister chromatid segregation (GO:0033046)3.19088047
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19088047
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19088047
111negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19088047
112protein localization to chromosome, centromeric region (GO:0071459)3.19071476
113protein targeting to mitochondrion (GO:0006626)3.18238866
114* positive regulation of cell cycle arrest (GO:0071158)3.17543644
115oxidative phosphorylation (GO:0006119)3.17139565
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.17041984
117DNA catabolic process, exonucleolytic (GO:0000738)3.16942353
118termination of RNA polymerase I transcription (GO:0006363)3.16626469
119rRNA methylation (GO:0031167)3.16554838
120folic acid-containing compound biosynthetic process (GO:0009396)3.15359020
121mitotic spindle checkpoint (GO:0071174)3.14888030
122* regulation of ligase activity (GO:0051340)3.14882527
123negative regulation of chromosome segregation (GO:0051985)3.13728338
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11858079
125* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10752569
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07356591
127nucleobase-containing small molecule interconversion (GO:0015949)3.06781689
128protein complex disassembly (GO:0043241)3.04196080
129histone exchange (GO:0043486)3.01913952
130transcription from RNA polymerase I promoter (GO:0006360)3.00523160
131protein localization to kinetochore (GO:0034501)2.99116628
132kinetochore organization (GO:0051383)2.96190560
133* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.96056900
134IMP biosynthetic process (GO:0006188)2.95891122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47595726
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.66355550
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19383066
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99233969
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.88663323
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.81415770
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47580018
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37201503
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35232124
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20170503
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07632654
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07368167
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00404755
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98013041
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81009309
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78202664
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73565107
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62969680
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57044643
20VDR_23849224_ChIP-Seq_CD4+_Human2.53276371
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52261619
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49848112
23XRN2_22483619_ChIP-Seq_HELA_Human2.37506856
24DCP1A_22483619_ChIP-Seq_HELA_Human2.37254584
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34819146
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34068372
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.30021934
28ELK1_19687146_ChIP-ChIP_HELA_Human2.16046627
29FOXP3_21729870_ChIP-Seq_TREG_Human2.09919151
30AR_21909140_ChIP-Seq_LNCAP_Human2.08208598
31GABP_19822575_ChIP-Seq_HepG2_Human2.00969177
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00796557
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00076784
34TTF2_22483619_ChIP-Seq_HELA_Human1.93625052
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.91923580
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88560977
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85830310
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84247964
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81550510
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77155086
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76360919
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76204043
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.72584575
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72281585
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67265398
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62701511
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60922370
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60881126
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.59133099
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56277754
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51183508
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48076245
53EWS_26573619_Chip-Seq_HEK293_Human1.38952638
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38892363
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38799497
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37883811
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33951651
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32240637
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.31330013
60KDM5A_27292631_Chip-Seq_BREAST_Human1.29706642
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27992805
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.27967276
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.25462463
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20071883
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19601357
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19014914
67CIITA_25753668_ChIP-Seq_RAJI_Human1.18132366
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18026675
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17866964
70FUS_26573619_Chip-Seq_HEK293_Human1.17608098
71MYC_18940864_ChIP-ChIP_HL60_Human1.15977394
72VDR_22108803_ChIP-Seq_LS180_Human1.12427335
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12300874
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11952268
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11001849
76TFEB_21752829_ChIP-Seq_HELA_Human1.09818801
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09718591
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09273951
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07152116
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06996174
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.05258050
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03471254
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02513975
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01940501
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.01197763
86* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98806764
87* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98408989
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98296104
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97343664
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96075084
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.93705281
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.93696670
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.89940202
94* SPI1_23547873_ChIP-Seq_NB4_Human0.88930296
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86729550
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85163857
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85050892
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84278320
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83556271
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83021227
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82390182
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.82254613
103ZNF274_21170338_ChIP-Seq_K562_Hela0.81850461
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80588021
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80112256
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73806433
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72679586
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71997127
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70866362
110* ELF5_23300383_ChIP-Seq_T47D_Human0.69878314
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69177232
112IRF1_19129219_ChIP-ChIP_H3396_Human0.69079412
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.68994612
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68976914
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68602987
116IGF1R_20145208_ChIP-Seq_DFB_Human0.68321631
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67927469
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.67669843
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65229469
120TAF15_26573619_Chip-Seq_HEK293_Human0.62496918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.76967610
2MP0004957_abnormal_blastocyst_morpholog4.88212506
3MP0010094_abnormal_chromosome_stability4.18215007
4MP0003111_abnormal_nucleus_morphology3.89833944
5MP0003806_abnormal_nucleotide_metabolis3.82420849
6MP0003077_abnormal_cell_cycle3.79007708
7MP0008058_abnormal_DNA_repair3.47643823
8MP0008057_abnormal_DNA_replication3.37115740
9MP0008932_abnormal_embryonic_tissue2.87391672
10MP0003186_abnormal_redox_activity2.77386327
11MP0008007_abnormal_cellular_replicative2.54613570
12MP0003718_maternal_effect2.46262383
13MP0009379_abnormal_foot_pigmentation2.24523075
14MP0001730_embryonic_growth_arrest2.18374423
15MP0003123_paternal_imprinting2.13312888
16MP0002938_white_spotting2.09337205
17MP0003786_premature_aging1.99710436
18MP0006036_abnormal_mitochondrial_physio1.97899225
19MP0006035_abnormal_mitochondrial_morpho1.90529984
20MP0002396_abnormal_hematopoietic_system1.85700902
21MP0000350_abnormal_cell_proliferation1.84043670
22MP0006072_abnormal_retinal_apoptosis1.80052773
23MP0003567_abnormal_fetal_cardiomyocyte1.68045788
24MP0008877_abnormal_DNA_methylation1.63366477
25MP0000372_irregular_coat_pigmentation1.58770701
26MP0009697_abnormal_copulation1.52725546
27MP0008789_abnormal_olfactory_epithelium1.50018069
28MP0009333_abnormal_splenocyte_physiolog1.45794070
29MP0001697_abnormal_embryo_size1.45681129
30MP0010030_abnormal_orbit_morphology1.44658724
31MP0010352_gastrointestinal_tract_polyps1.44465770
32MP0001764_abnormal_homeostasis1.43733713
33MP0003315_abnormal_perineum_morphology1.43613887
34MP0003221_abnormal_cardiomyocyte_apopto1.43482847
35MP0000490_abnormal_crypts_of1.40132782
36MP0000358_abnormal_cell_content/1.37987079
37MP0002080_prenatal_lethality1.36591939
38MP0005084_abnormal_gallbladder_morpholo1.34157959
39MP0001853_heart_inflammation1.33873115
40MP0001672_abnormal_embryogenesis/_devel1.32102762
41MP0005380_embryogenesis_phenotype1.32102762
42MP0002019_abnormal_tumor_incidence1.30870715
43MP0003136_yellow_coat_color1.27830128
44MP0000313_abnormal_cell_death1.25158808
45MP0008995_early_reproductive_senescence1.22908949
46MP0003937_abnormal_limbs/digits/tail_de1.22581653
47MP0003984_embryonic_growth_retardation1.19346095
48MP0002088_abnormal_embryonic_growth/wei1.16941063
49MP0002132_abnormal_respiratory_system1.16128981
50MP0001835_abnormal_antigen_presentation1.15702773
51MP0001188_hyperpigmentation1.08902904
52MP0001727_abnormal_embryo_implantation1.08184960
53MP0001286_abnormal_eye_development1.08165868
54MP0010307_abnormal_tumor_latency1.04578166
55MP0004147_increased_porphyrin_level1.01695422
56MP0005266_abnormal_metabolism1.00300294
57MP0009672_abnormal_birth_weight0.98894395
58MP0009785_altered_susceptibility_to0.95700197
59MP0002751_abnormal_autonomic_nervous0.95314368
60MP0002736_abnormal_nociception_after0.93511088
61MP0002085_abnormal_embryonic_tissue0.93474495
62MP0005408_hypopigmentation0.93374452
63MP0002086_abnormal_extraembryonic_tissu0.92808182
64MP0003011_delayed_dark_adaptation0.91466199
65MP0002233_abnormal_nose_morphology0.91420940
66MP0005499_abnormal_olfactory_system0.89733375
67MP0005394_taste/olfaction_phenotype0.89733375
68MP0004197_abnormal_fetal_growth/weight/0.89375764
69MP0002697_abnormal_eye_size0.89120746
70MP0002210_abnormal_sex_determination0.88917996
71MP0002160_abnormal_reproductive_system0.88525520
72MP0005332_abnormal_amino_acid0.88410438
73MP0002234_abnormal_pharynx_morphology0.88221703
74MP0001346_abnormal_lacrimal_gland0.87014631
75MP0002722_abnormal_immune_system0.86111679
76MP0002090_abnormal_vision0.85915837
77MP0005253_abnormal_eye_physiology0.85386879
78MP0001545_abnormal_hematopoietic_system0.85332152
79MP0005397_hematopoietic_system_phenotyp0.85332152
80MP0003121_genomic_imprinting0.84149682
81MP0005075_abnormal_melanosome_morpholog0.84123258
82MP0000689_abnormal_spleen_morphology0.82642069
83MP0005085_abnormal_gallbladder_physiolo0.82054715
84MP0001145_abnormal_male_reproductive0.82040364
85MP0005389_reproductive_system_phenotype0.80734121
86MP0002398_abnormal_bone_marrow0.80038754
87MP0002111_abnormal_tail_morphology0.79994000
88MP0006054_spinal_hemorrhage0.79701140
89MP0005376_homeostasis/metabolism_phenot0.79273372
90MP0002084_abnormal_developmental_patter0.77910361
91MP0002163_abnormal_gland_morphology0.76919468
92MP0004133_heterotaxia0.76718355
93MP0000647_abnormal_sebaceous_gland0.76716497
94MP0002429_abnormal_blood_cell0.76262821
95MP0004808_abnormal_hematopoietic_stem0.75898464
96MP0003119_abnormal_digestive_system0.75542850
97MP0005360_urolithiasis0.74676588
98MP0002139_abnormal_hepatobiliary_system0.74390907
99MP0002148_abnormal_hypersensitivity_rea0.74369006
100MP0001542_abnormal_bone_strength0.74325763
101MP0001119_abnormal_female_reproductive0.74242675
102MP0001293_anophthalmia0.74188407
103MP0003941_abnormal_skin_development0.74073940
104MP0003195_calcinosis0.74027322
105MP0003890_abnormal_embryonic-extraembry0.73510983
106MP0005395_other_phenotype0.73402815
107MP0000858_altered_metastatic_potential0.73081023
108MP0004215_abnormal_myocardial_fiber0.72253476
109MP0000653_abnormal_sex_gland0.70332948
110MP0000049_abnormal_middle_ear0.70267033
111MP0008260_abnormal_autophagy0.70001017
112MP0001485_abnormal_pinna_reflex0.69869125
113MP0005451_abnormal_body_composition0.69833547
114MP0000537_abnormal_urethra_morphology0.69336568
115MP0000598_abnormal_liver_morphology0.68590331
116MP0000703_abnormal_thymus_morphology0.67788686
117MP0008875_abnormal_xenobiotic_pharmacok0.67542209
118MP0005319_abnormal_enzyme/_coenzyme0.67237027
119MP0001881_abnormal_mammary_gland0.66174169
120MP0003763_abnormal_thymus_physiology0.66134326
121MP0005391_vision/eye_phenotype0.66095955
122MP0002282_abnormal_trachea_morphology0.64066213
123MP0001529_abnormal_vocalization0.63785000
124MP0005384_cellular_phenotype0.63517239
125MP0009053_abnormal_anal_canal0.63388988
126MP0008872_abnormal_physiological_respon0.63357070
127MP0005501_abnormal_skin_physiology0.63051685
128MP0005671_abnormal_response_to0.61986912
129MP0006292_abnormal_olfactory_placode0.61280208
130MP0000631_abnormal_neuroendocrine_gland0.60521443
131MP0002837_dystrophic_cardiac_calcinosis0.60311277
132MP0000716_abnormal_immune_system0.59969110
133MP0008469_abnormal_protein_level0.59011771
134MP0002102_abnormal_ear_morphology0.58541994
135MP0003698_abnormal_male_reproductive0.58136243
136MP0002277_abnormal_respiratory_mucosa0.57664577
137MP0005025_abnormal_response_to0.57541888
138MP0001929_abnormal_gametogenesis0.57500756
139MP0009840_abnormal_foam_cell0.57465411
140MP0008873_increased_physiological_sensi0.54562700
141MP0003938_abnormal_ear_development0.53869826

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.12230096
2Birth length less than 3rd percentile (HP:0003561)4.74443955
3Abnormal number of erythroid precursors (HP:0012131)4.64848837
4Reticulocytopenia (HP:0001896)4.48168613
5Increased serum pyruvate (HP:0003542)4.19773000
6Abnormality of glycolysis (HP:0004366)4.19773000
7Acute necrotizing encephalopathy (HP:0006965)4.16256376
8Oral leukoplakia (HP:0002745)3.85927329
9Macrocytic anemia (HP:0001972)3.85432754
10Abnormal mitochondria in muscle tissue (HP:0008316)3.81321373
11Breast hypoplasia (HP:0003187)3.77320641
12Mitochondrial inheritance (HP:0001427)3.76573160
13Increased CSF lactate (HP:0002490)3.76392519
14Acute encephalopathy (HP:0006846)3.60737710
15Increased hepatocellular lipid droplets (HP:0006565)3.60123150
16Hepatocellular necrosis (HP:0001404)3.51785994
17Hepatic necrosis (HP:0002605)3.44043226
18Lipid accumulation in hepatocytes (HP:0006561)3.38682861
19Increased serum lactate (HP:0002151)3.34356085
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25269688
21Progressive macrocephaly (HP:0004481)3.24950413
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20078431
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20078431
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15611396
25Multiple enchondromatosis (HP:0005701)3.11387737
26Pallor (HP:0000980)3.11051946
27Rough bone trabeculation (HP:0100670)3.08082117
28Cerebral edema (HP:0002181)3.05325903
29Aplastic anemia (HP:0001915)3.02504119
30Abnormality of methionine metabolism (HP:0010901)2.97296364
31Cerebral hypomyelination (HP:0006808)2.96074226
32Colon cancer (HP:0003003)2.92263311
33Carpal bone hypoplasia (HP:0001498)2.91947875
34Meckel diverticulum (HP:0002245)2.91735313
35Degeneration of anterior horn cells (HP:0002398)2.91453433
36Abnormality of the anterior horn cell (HP:0006802)2.91453433
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82203142
38Abnormality of the labia minora (HP:0012880)2.79061321
39Lactic acidosis (HP:0003128)2.77711590
40Abnormality of the ileum (HP:0001549)2.74971422
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.72721167
42Abnormal lung lobation (HP:0002101)2.70014122
43Exertional dyspnea (HP:0002875)2.69916406
44Megaloblastic anemia (HP:0001889)2.68021931
45Exercise intolerance (HP:0003546)2.67700195
46Respiratory difficulties (HP:0002880)2.60477353
47Microretrognathia (HP:0000308)2.59643489
48Increased intramyocellular lipid droplets (HP:0012240)2.58358688
49Hypobetalipoproteinemia (HP:0003563)2.54654796
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52775426
513-Methylglutaconic aciduria (HP:0003535)2.52479905
52Methylmalonic acidemia (HP:0002912)2.51339623
53Respiratory failure (HP:0002878)2.50347142
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49391402
55Abnormality of alanine metabolism (HP:0010916)2.49391402
56Hyperalaninemia (HP:0003348)2.49391402
57Renal Fanconi syndrome (HP:0001994)2.48118027
58Congenital, generalized hypertrichosis (HP:0004540)2.47681450
59Nausea (HP:0002018)2.47354265
60Microvesicular hepatic steatosis (HP:0001414)2.45815438
61Agnosia (HP:0010524)2.42879236
62Trismus (HP:0000211)2.40540536
63Abnormal trabecular bone morphology (HP:0100671)2.36420716
64CNS demyelination (HP:0007305)2.34571579
65Secondary amenorrhea (HP:0000869)2.33149745
66Abnormality of pyrimidine metabolism (HP:0004353)2.31592420
67Patellar aplasia (HP:0006443)2.29648969
68Duodenal stenosis (HP:0100867)2.29180802
69Small intestinal stenosis (HP:0012848)2.29180802
70Increased muscle lipid content (HP:0009058)2.28854357
71Optic disc pallor (HP:0000543)2.26420798
72Aplasia/Hypoplasia of the patella (HP:0006498)2.23283809
73Amniotic constriction ring (HP:0009775)2.21134066
74Abnormality of placental membranes (HP:0011409)2.21134066
75Cellular immunodeficiency (HP:0005374)2.21053846
76Pancytopenia (HP:0001876)2.19501662
77Premature ovarian failure (HP:0008209)2.19019037
78Premature graying of hair (HP:0002216)2.18200700
79Lethargy (HP:0001254)2.14160836
80Methylmalonic aciduria (HP:0012120)2.12879922
81Poor head control (HP:0002421)2.11308057
82Triphalangeal thumb (HP:0001199)2.11116483
83Postnatal microcephaly (HP:0005484)2.11104770
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09180855
85Abnormality of renal resorption (HP:0011038)2.06372526
86Sparse eyelashes (HP:0000653)2.04893832
87Absent thumb (HP:0009777)2.03443056
88Abnormality of serum amino acid levels (HP:0003112)2.02006092
89Leukodystrophy (HP:0002415)2.01235346
90Abnormality of the preputium (HP:0100587)2.00655427
91Cleft eyelid (HP:0000625)2.00549977
92Abnormal protein glycosylation (HP:0012346)1.99882593
93Abnormal glycosylation (HP:0012345)1.99882593
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99882593
95Abnormal protein N-linked glycosylation (HP:0012347)1.99882593
96Abnormality of the duodenum (HP:0002246)1.99730643
97Volvulus (HP:0002580)1.98390071
98Myelodysplasia (HP:0002863)1.95872334
99Neoplasm of the pancreas (HP:0002894)1.94720929
100Homocystinuria (HP:0002156)1.94205188
101Abnormality of homocysteine metabolism (HP:0010919)1.94205188
102Thrombocytosis (HP:0001894)1.94030193
103Horseshoe kidney (HP:0000085)1.93814724
104CNS hypomyelination (HP:0003429)1.92710426
105Generalized aminoaciduria (HP:0002909)1.92285709
106Irregular epiphyses (HP:0010582)1.91272656
107Septo-optic dysplasia (HP:0100842)1.90561802
108Selective tooth agenesis (HP:0001592)1.89819218
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89309685
110Hyperglycinemia (HP:0002154)1.88956885
111Neoplasm of the colon (HP:0100273)1.88766106
112Glossoptosis (HP:0000162)1.88468000
113Abnormal hemoglobin (HP:0011902)1.87940041
114Abnormality of urine glucose concentration (HP:0011016)1.86350695
115Glycosuria (HP:0003076)1.86350695
116Stenosis of the external auditory canal (HP:0000402)1.85278693
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84964115
118Emotional lability (HP:0000712)1.84658942
119Neoplasm of the adrenal gland (HP:0100631)1.83399841
120Nephroblastoma (Wilms tumor) (HP:0002667)1.82370452
121Bone marrow hypocellularity (HP:0005528)1.79472905
122Abnormality of chromosome stability (HP:0003220)1.79014220
123Medulloblastoma (HP:0002885)1.78549292
124Sloping forehead (HP:0000340)1.78302349
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.78245062
126Type I transferrin isoform profile (HP:0003642)1.78023838
127Abnormality of the umbilical cord (HP:0010881)1.77950437
128Prolonged neonatal jaundice (HP:0006579)1.77034928
129Hypoglycemic coma (HP:0001325)1.75390735
13011 pairs of ribs (HP:0000878)1.75058140
131Embryonal renal neoplasm (HP:0011794)1.74443744
132Rhabdomyolysis (HP:0003201)1.74223650
133Absent septum pellucidum (HP:0001331)1.73883505
134X-linked dominant inheritance (HP:0001423)1.73428800
135Absent radius (HP:0003974)1.70554661
136Chromsome breakage (HP:0040012)1.70514557
137Reduced antithrombin III activity (HP:0001976)1.70107833
138Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68685108
139Dicarboxylic aciduria (HP:0003215)1.68685108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41126712
2VRK24.27194445
3EIF2AK14.18359343
4WEE14.16980410
5NME23.75903134
6STK163.19943463
7CDC73.09324577
8SRPK12.79032917
9EIF2AK32.77975897
10ACVR1B2.36414028
11TSSK62.35929451
12PBK2.30463661
13PLK42.18212446
14TRIM282.12183631
15VRK11.83869040
16NUAK11.81850614
17BRSK21.80356020
18PIM21.77995869
19NEK11.72075721
20TAF11.69613251
21MKNK11.68569561
22BCKDK1.67248088
23NME11.62643176
24NEK21.61198829
25DYRK31.59647325
26PLK11.59582442
27TTK1.57466231
28PLK31.54322944
29TESK21.46493352
30WNK31.41237159
31AURKB1.38301195
32MST41.33064571
33PASK1.27535973
34BMPR1B1.26499831
35TGFBR11.20550955
36AURKA1.19248477
37ARAF1.18101089
38SCYL21.17915600
39RPS6KA41.16871644
40TLK11.14778551
41CCNB11.14684193
42TNIK1.14293828
43EIF2AK21.12078740
44PNCK1.09910473
45TESK11.08192990
46CDK71.06604968
47ATR1.04340988
48ZAK1.03817547
49KDR1.03047852
50RPS6KB21.01263088
51EPHA21.01259074
52BRAF0.99364325
53MAP4K20.91867798
54ABL20.91381497
55LIMK10.86824142
56PAK40.86668487
57CHEK20.86571880
58CDK40.84216225
59PDK30.83616936
60PDK40.83616936
61MAP3K80.82794167
62BRSK10.82695018
63MAP3K120.81610433
64CSNK2A10.81319425
65MKNK20.79977281
66STK38L0.79192677
67CSNK2A20.78916384
68CSNK1G10.76290375
69ILK0.76060297
70STK40.72014044
71CDK80.68954488
72CHEK10.68042054
73ALK0.67674812
74CSNK1G20.66506697
75PAK10.64817518
76BLK0.64422185
77MYLK0.63339621
78DYRK20.62252088
79STK240.60292980
80PLK20.59532026
81PIM10.57994556
82LRRK20.56404765
83MAP3K30.56193566
84CSNK1A1L0.56115294
85STK30.55445530
86BCR0.53595728
87INSRR0.52817132
88PRKCI0.52363148
89CLK10.52186030
90MAP3K110.50325564
91RPS6KA50.50224837
92NEK90.50210699
93TEC0.49903951
94MAP2K30.49322212
95CDK190.47969093
96FLT30.47689680
97PDK20.46519995
98OXSR10.45695568
99GRK10.44040839
100ATM0.43724538
101ERBB40.42710926
102CSNK1G30.41631720
103RAF10.41051558
104CDK20.40822211
105STK100.40750685
106IRAK40.39874811
107GRK60.39664573
108ZAP700.39039210
109MAP3K50.39000550
110ERBB30.38224100
111FGFR10.34272872
112MAPKAPK50.33920496
113CDK60.32900469
114MELK0.32768988
115MINK10.31762961
116MAP2K70.31266312
117DAPK10.30192892
118OBSCN0.30068291
119CDK30.30045024
120CDK10.29245843
121ADRBK20.28572242
122IKBKB0.26517619
123PRKDC0.24162665
124MARK30.23949286
125CSNK1E0.23886403
126CDK140.22131082
127CDK180.21241953
128CSNK1A10.21049356
129PRKCG0.20597781
130DAPK30.19111189

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.17774694
2Ribosome_Homo sapiens_hsa030104.23191182
3DNA replication_Homo sapiens_hsa030304.00901553
4RNA polymerase_Homo sapiens_hsa030203.44640404
5Mismatch repair_Homo sapiens_hsa034303.40041697
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31350418
7Spliceosome_Homo sapiens_hsa030402.78054762
8RNA transport_Homo sapiens_hsa030132.54468137
9Nucleotide excision repair_Homo sapiens_hsa034202.53770926
10Pyrimidine metabolism_Homo sapiens_hsa002402.52353217
11Homologous recombination_Homo sapiens_hsa034402.31426177
12One carbon pool by folate_Homo sapiens_hsa006702.22602746
13Base excision repair_Homo sapiens_hsa034102.21830971
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13019635
15Oxidative phosphorylation_Homo sapiens_hsa001902.08990544
16Parkinsons disease_Homo sapiens_hsa050121.91732950
17Cell cycle_Homo sapiens_hsa041101.77322248
18Protein export_Homo sapiens_hsa030601.62454632
19Basal transcription factors_Homo sapiens_hsa030221.55684178
20Huntingtons disease_Homo sapiens_hsa050161.54770719
21Non-homologous end-joining_Homo sapiens_hsa034501.51874788
22RNA degradation_Homo sapiens_hsa030181.45409041
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43136453
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38693352
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35197017
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.29270498
27Purine metabolism_Homo sapiens_hsa002301.26070344
28Folate biosynthesis_Homo sapiens_hsa007901.24480179
29Fanconi anemia pathway_Homo sapiens_hsa034601.21668271
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.18619163
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17378984
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16798547
33Alzheimers disease_Homo sapiens_hsa050101.12474444
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09703500
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06840725
36Glutathione metabolism_Homo sapiens_hsa004801.06636400
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04530678
38Carbon metabolism_Homo sapiens_hsa012001.02557938
39p53 signaling pathway_Homo sapiens_hsa041151.02185796
40Epstein-Barr virus infection_Homo sapiens_hsa051691.01976472
41Biosynthesis of amino acids_Homo sapiens_hsa012300.99771771
42Pentose phosphate pathway_Homo sapiens_hsa000300.98285942
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92749686
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92422334
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83912952
46mRNA surveillance pathway_Homo sapiens_hsa030150.82863759
47Sulfur relay system_Homo sapiens_hsa041220.82441567
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.80903327
49Systemic lupus erythematosus_Homo sapiens_hsa053220.80646091
50Selenocompound metabolism_Homo sapiens_hsa004500.80421925
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78758872
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74435863
53Legionellosis_Homo sapiens_hsa051340.72463218
54Antigen processing and presentation_Homo sapiens_hsa046120.68195611
55Pyruvate metabolism_Homo sapiens_hsa006200.68178434
56Vitamin B6 metabolism_Homo sapiens_hsa007500.65968031
57Sulfur metabolism_Homo sapiens_hsa009200.65755780
58Metabolic pathways_Homo sapiens_hsa011000.60618711
59Propanoate metabolism_Homo sapiens_hsa006400.55665394
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55512640
61Herpes simplex infection_Homo sapiens_hsa051680.54811871
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51974975
63Peroxisome_Homo sapiens_hsa041460.46624567
64Oocyte meiosis_Homo sapiens_hsa041140.44721060
65Butanoate metabolism_Homo sapiens_hsa006500.43387698
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43326868
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43224678
68Fatty acid elongation_Homo sapiens_hsa000620.43013193
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42681248
70Phenylalanine metabolism_Homo sapiens_hsa003600.42123932
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41814428
72Arginine and proline metabolism_Homo sapiens_hsa003300.40920736
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39793457
74Fructose and mannose metabolism_Homo sapiens_hsa000510.39396391
75Allograft rejection_Homo sapiens_hsa053300.38832553
76Viral carcinogenesis_Homo sapiens_hsa052030.38641237
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38209295
78Caffeine metabolism_Homo sapiens_hsa002320.38013930
79Tryptophan metabolism_Homo sapiens_hsa003800.37571258
80N-Glycan biosynthesis_Homo sapiens_hsa005100.36773388
81beta-Alanine metabolism_Homo sapiens_hsa004100.35752841
82Chemical carcinogenesis_Homo sapiens_hsa052040.34625683
83Asthma_Homo sapiens_hsa053100.34181168
84Tyrosine metabolism_Homo sapiens_hsa003500.32695963
85Fatty acid metabolism_Homo sapiens_hsa012120.31274751
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31271132
87Arachidonic acid metabolism_Homo sapiens_hsa005900.29272927
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28895228
89Steroid biosynthesis_Homo sapiens_hsa001000.28370056
90Regulation of autophagy_Homo sapiens_hsa041400.27315302
91Galactose metabolism_Homo sapiens_hsa000520.24654806
92Phototransduction_Homo sapiens_hsa047440.24219989
93Retinol metabolism_Homo sapiens_hsa008300.24218456
94Collecting duct acid secretion_Homo sapiens_hsa049660.23158748
95Shigellosis_Homo sapiens_hsa051310.22389600
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20755195
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20606534
98Cardiac muscle contraction_Homo sapiens_hsa042600.20306690
99Vitamin digestion and absorption_Homo sapiens_hsa049770.18892384
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18173867
101Graft-versus-host disease_Homo sapiens_hsa053320.17702196
102Thyroid cancer_Homo sapiens_hsa052160.17588378
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.17242269
104Fatty acid degradation_Homo sapiens_hsa000710.16969398
105Histidine metabolism_Homo sapiens_hsa003400.16640488
106TGF-beta signaling pathway_Homo sapiens_hsa043500.16335108
107HTLV-I infection_Homo sapiens_hsa051660.15331811
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14374598
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13374217
110Renin-angiotensin system_Homo sapiens_hsa046140.13305019
111Type I diabetes mellitus_Homo sapiens_hsa049400.13194664
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13028671
113Nitrogen metabolism_Homo sapiens_hsa009100.10709121
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.09843490
115Fat digestion and absorption_Homo sapiens_hsa049750.09368506
116Basal cell carcinoma_Homo sapiens_hsa052170.07852209

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