PSMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.17667102
2proteasome assembly (GO:0043248)4.73812420
3DNA strand elongation involved in DNA replication (GO:0006271)4.66176168
4telomere maintenance via semi-conservative replication (GO:0032201)4.60081761
5formation of translation preinitiation complex (GO:0001731)4.51002353
6DNA strand elongation (GO:0022616)4.46075886
7DNA deamination (GO:0045006)4.43182656
8* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39639595
9maturation of SSU-rRNA (GO:0030490)4.34121812
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.23174389
11telomere maintenance via recombination (GO:0000722)4.15690800
12* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14252262
13* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12343825
14* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.06803401
15DNA replication initiation (GO:0006270)4.04423372
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02854743
17purine nucleobase biosynthetic process (GO:0009113)4.01953754
18viral transcription (GO:0019083)4.00172397
19nucleobase biosynthetic process (GO:0046112)3.99726357
20* negative regulation of ligase activity (GO:0051352)3.96581010
21* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96581010
22* regulation of cellular amino acid metabolic process (GO:0006521)3.94634678
23translational termination (GO:0006415)3.93872680
24* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.90266460
25* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.89846136
26* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.84348246
27* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.84348246
28ribosomal small subunit biogenesis (GO:0042274)3.83669612
29mitotic recombination (GO:0006312)3.83338110
30chaperone-mediated protein transport (GO:0072321)3.83333591
31* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81748768
32* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81748768
33* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81748768
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79337728
35CENP-A containing nucleosome assembly (GO:0034080)3.79224895
36establishment of viral latency (GO:0019043)3.77998821
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.77087313
38ribosomal large subunit biogenesis (GO:0042273)3.76428396
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.75568682
40* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.71441878
41* signal transduction involved in DNA damage checkpoint (GO:0072422)3.71441878
42* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.70461529
43cotranslational protein targeting to membrane (GO:0006613)3.68002410
44* signal transduction involved in cell cycle checkpoint (GO:0072395)3.65934792
45DNA replication checkpoint (GO:0000076)3.65393398
46respiratory electron transport chain (GO:0022904)3.64814158
47translational elongation (GO:0006414)3.64469517
48protein targeting to ER (GO:0045047)3.63747631
49cullin deneddylation (GO:0010388)3.61291435
50chromatin remodeling at centromere (GO:0031055)3.58734997
51protein neddylation (GO:0045116)3.56965794
52* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56572742
53electron transport chain (GO:0022900)3.54964030
54protein deneddylation (GO:0000338)3.54166479
55translational initiation (GO:0006413)3.51794859
56protein localization to endoplasmic reticulum (GO:0070972)3.49326905
57telomere maintenance via telomere lengthening (GO:0010833)3.49181621
58ribonucleoprotein complex biogenesis (GO:0022613)3.48961567
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43890082
60ATP synthesis coupled proton transport (GO:0015986)3.43890082
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43077737
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43041570
63spliceosomal snRNP assembly (GO:0000387)3.42744490
64translation (GO:0006412)3.42507998
65* positive regulation of ligase activity (GO:0051351)3.42496499
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.41985060
67viral mRNA export from host cell nucleus (GO:0046784)3.37841982
68termination of RNA polymerase III transcription (GO:0006386)3.36879465
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.36879465
70ribosome assembly (GO:0042255)3.36840839
71* regulation of cellular amine metabolic process (GO:0033238)3.36215130
72pseudouridine synthesis (GO:0001522)3.33408705
73protein complex biogenesis (GO:0070271)3.33337806
74histone exchange (GO:0043486)3.32983282
75* negative regulation of protein ubiquitination (GO:0031397)3.32551796
76* cell cycle G1/S phase transition (GO:0044843)3.32520132
77* G1/S transition of mitotic cell cycle (GO:0000082)3.32520132
78rRNA modification (GO:0000154)3.31470766
79DNA unwinding involved in DNA replication (GO:0006268)3.30885284
807-methylguanosine mRNA capping (GO:0006370)3.30090074
81respiratory chain complex IV assembly (GO:0008535)3.29860323
82mitochondrial respiratory chain complex assembly (GO:0033108)3.29665221
83DNA ligation (GO:0006266)3.29543191
84protein targeting to mitochondrion (GO:0006626)3.29480671
85nucleobase-containing small molecule interconversion (GO:0015949)3.28770058
86ribosome biogenesis (GO:0042254)3.28724189
87RNA capping (GO:0036260)3.26168513
887-methylguanosine RNA capping (GO:0009452)3.26168513
89rRNA processing (GO:0006364)3.24795173
90DNA catabolic process, exonucleolytic (GO:0000738)3.24620573
91DNA replication-independent nucleosome organization (GO:0034724)3.24166908
92DNA replication-independent nucleosome assembly (GO:0006336)3.24166908
93transcription-coupled nucleotide-excision repair (GO:0006283)3.23973814
94establishment of integrated proviral latency (GO:0075713)3.19363939
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18794572
96mitochondrial respiratory chain complex I assembly (GO:0032981)3.18794572
97NADH dehydrogenase complex assembly (GO:0010257)3.18794572
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18686549
99viral life cycle (GO:0019058)3.16485803
100* regulation of ubiquitin-protein transferase activity (GO:0051438)3.16190417
101regulation of mitochondrial translation (GO:0070129)3.15905138
102deoxyribonucleotide biosynthetic process (GO:0009263)3.15139704
103mitotic metaphase plate congression (GO:0007080)3.15070028
104IMP biosynthetic process (GO:0006188)3.13617010
105oxidative phosphorylation (GO:0006119)3.12720107
106DNA double-strand break processing (GO:0000729)3.11738722
107* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.11640289
108protein localization to mitochondrion (GO:0070585)3.11456507
109cellular protein complex disassembly (GO:0043624)3.11063435
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10764095
111rRNA metabolic process (GO:0016072)3.10726304
112* positive regulation of cell cycle arrest (GO:0071158)3.09760967
113cellular component biogenesis (GO:0044085)3.07664142
114* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06829641
115* regulation of ligase activity (GO:0051340)3.06182094
116kinetochore organization (GO:0051383)3.05273603
117tRNA aminoacylation for protein translation (GO:0006418)3.05152928
118* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.04220065
119DNA damage response, detection of DNA damage (GO:0042769)3.04158707
120establishment of protein localization to mitochondrion (GO:0072655)3.02978274
121amino acid activation (GO:0043038)3.02081438
122tRNA aminoacylation (GO:0043039)3.02081438
123peptidyl-histidine modification (GO:0018202)2.98800007
124* signal transduction in response to DNA damage (GO:0042770)2.97512868
125spliceosomal complex assembly (GO:0000245)2.97297785
126metaphase plate congression (GO:0051310)2.96831159
1272-deoxyribonucleotide biosynthetic process (GO:0009265)2.96599817
128deoxyribose phosphate biosynthetic process (GO:0046385)2.96599817
129IMP metabolic process (GO:0046040)2.95128649
130kinetochore assembly (GO:0051382)2.94375384
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91316032
132protein localization to kinetochore (GO:0034501)2.90756093
133tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90488207
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90488207
135guanosine-containing compound biosynthetic process (GO:1901070)2.89544459
136inner mitochondrial membrane organization (GO:0007007)2.88568937
137cytochrome complex assembly (GO:0017004)2.88497316
138mitotic spindle checkpoint (GO:0071174)2.87937063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50037195
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25010319
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19046354
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.13255814
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.79911836
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.72159035
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53874520
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.22589925
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18074997
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05227565
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01383624
12* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87472405
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87234100
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81121418
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76547860
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68613118
17* VDR_23849224_ChIP-Seq_CD4+_Human2.58072106
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55848357
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55768860
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45695717
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41493979
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39279958
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37959935
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36009348
25DCP1A_22483619_ChIP-Seq_HELA_Human2.32260884
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32107490
27XRN2_22483619_ChIP-Seq_HELA_Human2.32105555
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.28133617
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.17929624
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11181660
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.10260237
32GABP_19822575_ChIP-Seq_HepG2_Human2.05251257
33ELK1_19687146_ChIP-ChIP_HELA_Human2.02818542
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00991284
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98609325
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94899653
37TTF2_22483619_ChIP-Seq_HELA_Human1.91097633
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88278005
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.80392453
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79081004
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76041944
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76002593
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73189396
44* AR_21909140_ChIP-Seq_LNCAP_Human1.70962096
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68893203
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67417251
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64213732
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60747651
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60481023
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58116962
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54965927
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53529723
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.51594291
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44335851
55CIITA_25753668_ChIP-Seq_RAJI_Human1.41723832
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37676502
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.36870962
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34638911
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26742982
60KDM5A_27292631_Chip-Seq_BREAST_Human1.21520511
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19511078
62SPI1_23547873_ChIP-Seq_NB4_Human1.18127398
63* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17844312
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.17801471
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17374342
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16489756
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15507918
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14842751
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.14657936
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12410971
71TFEB_21752829_ChIP-Seq_HELA_Human1.11877559
72EWS_26573619_Chip-Seq_HEK293_Human1.10035552
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08192666
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08054825
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05337626
76MYC_18940864_ChIP-ChIP_HL60_Human1.04851169
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03693674
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03402301
79* NANOG_16153702_ChIP-ChIP_HESCs_Human1.02942382
80* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02473631
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99531438
82VDR_22108803_ChIP-Seq_LS180_Human0.97967594
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97443748
84EGR1_19374776_ChIP-ChIP_THP-1_Human0.96532510
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94166395
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92678249
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92039849
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91260965
89FUS_26573619_Chip-Seq_HEK293_Human0.91216284
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.89663008
91ZNF274_21170338_ChIP-Seq_K562_Hela0.89390873
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88883258
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.88576458
94GATA1_22025678_ChIP-Seq_K562_Human0.85750978
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85066106
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.85048215
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82547602
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82216484
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81388259
100MYC_22102868_ChIP-Seq_BL_Human0.80859133
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.80382843
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80208954
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78591969
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78551278
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77133687
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.75020179
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74795778
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73995366
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73653756
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73515364
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73362306
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73350114
113ELF5_23300383_ChIP-Seq_T47D_Human0.73347148
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73262657
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72516183
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71605206
117IRF1_19129219_ChIP-ChIP_H3396_Human0.70907762
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69209336
119* SALL4_22934838_ChIP-ChIP_CD34+_Human0.65942569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.64525111
2MP0004957_abnormal_blastocyst_morpholog4.43122634
3MP0010094_abnormal_chromosome_stability4.10156837
4MP0003077_abnormal_cell_cycle3.71161911
5MP0003111_abnormal_nucleus_morphology3.68938073
6MP0008057_abnormal_DNA_replication3.32982601
7MP0008058_abnormal_DNA_repair3.27567277
8MP0003806_abnormal_nucleotide_metabolis3.18855087
9MP0008007_abnormal_cellular_replicative2.90755589
10MP0003186_abnormal_redox_activity2.64339684
11MP0002396_abnormal_hematopoietic_system2.56230047
12MP0008932_abnormal_embryonic_tissue2.47413183
13MP0002102_abnormal_ear_morphology2.21029141
14MP0006036_abnormal_mitochondrial_physio2.14428441
15MP0003786_premature_aging2.04035427
16MP0001835_abnormal_antigen_presentation1.99513346
17MP0002938_white_spotting1.95506141
18MP0009333_abnormal_splenocyte_physiolog1.95323635
19MP0003123_paternal_imprinting1.92097716
20MP0006072_abnormal_retinal_apoptosis1.85800790
21MP0003941_abnormal_skin_development1.85034767
22MP0000490_abnormal_crypts_of1.84642859
23MP0003718_maternal_effect1.80300486
24MP0009785_altered_susceptibility_to1.76910978
25MP0004147_increased_porphyrin_level1.76359459
26MP0001853_heart_inflammation1.72754324
27MP0001730_embryonic_growth_arrest1.71097661
28MP0000350_abnormal_cell_proliferation1.63333763
29MP0002132_abnormal_respiratory_system1.62112758
30MP0009379_abnormal_foot_pigmentation1.60334083
31MP0006035_abnormal_mitochondrial_morpho1.59740088
32MP0009697_abnormal_copulation1.57653619
33MP0005084_abnormal_gallbladder_morpholo1.52483149
34MP0005397_hematopoietic_system_phenotyp1.51533467
35MP0001545_abnormal_hematopoietic_system1.51533467
36MP0001293_anophthalmia1.46143377
37MP0003656_abnormal_erythrocyte_physiolo1.41758909
38MP0002148_abnormal_hypersensitivity_rea1.40941224
39MP0002019_abnormal_tumor_incidence1.38952989
40MP0000313_abnormal_cell_death1.38927472
41MP0005075_abnormal_melanosome_morpholog1.36223861
42MP0002398_abnormal_bone_marrow1.35851059
43MP0005671_abnormal_response_to1.35338444
44MP0003763_abnormal_thymus_physiology1.34381693
45MP0000358_abnormal_cell_content/1.33767230
46MP0008877_abnormal_DNA_methylation1.33290608
47MP0003221_abnormal_cardiomyocyte_apopto1.32878607
48MP0003136_yellow_coat_color1.32054770
49MP0001764_abnormal_homeostasis1.32012319
50MP0000689_abnormal_spleen_morphology1.31910213
51MP0006054_spinal_hemorrhage1.29548574
52MP0002722_abnormal_immune_system1.28190106
53MP0004808_abnormal_hematopoietic_stem1.25306455
54MP0002090_abnormal_vision1.23977381
55MP0005025_abnormal_response_to1.20374672
56MP0002429_abnormal_blood_cell1.18613989
57MP0002080_prenatal_lethality1.18062337
58MP0003567_abnormal_fetal_cardiomyocyte1.16383172
59MP0002837_dystrophic_cardiac_calcinosis1.10175031
60MP0001697_abnormal_embryo_size1.09293985
61MP0000647_abnormal_sebaceous_gland1.08684486
62MP0002420_abnormal_adaptive_immunity1.07833762
63MP0000716_abnormal_immune_system1.07832965
64MP0000858_altered_metastatic_potential1.07187999
65MP0005171_absent_coat_pigmentation1.06601076
66MP0001819_abnormal_immune_cell1.06474373
67MP0003950_abnormal_plasma_membrane1.05410174
68MP0005253_abnormal_eye_physiology1.05342274
69MP0002452_abnormal_antigen_presenting1.05193644
70MP0001800_abnormal_humoral_immune1.04360086
71MP0003724_increased_susceptibility_to1.04341780
72MP0003436_decreased_susceptibility_to1.04276178
73MP0005266_abnormal_metabolism1.03133745
74MP0008260_abnormal_autophagy1.02168706
75MP0005000_abnormal_immune_tolerance1.01900906
76MP0001929_abnormal_gametogenesis1.00566236
77MP0000685_abnormal_immune_system0.99697953
78MP0002723_abnormal_immune_serum0.99090603
79MP0010352_gastrointestinal_tract_polyps0.99042822
80MP0002095_abnormal_skin_pigmentation0.98707978
81MP0003195_calcinosis0.97704357
82MP0003315_abnormal_perineum_morphology0.97431992
83MP0002419_abnormal_innate_immunity0.97029620
84MP0006292_abnormal_olfactory_placode0.96923497
85MP0000703_abnormal_thymus_morphology0.94585636
86MP0002163_abnormal_gland_morphology0.94105577
87MP0005380_embryogenesis_phenotype0.93975101
88MP0001672_abnormal_embryogenesis/_devel0.93975101
89MP0010307_abnormal_tumor_latency0.91948300
90MP0008789_abnormal_olfactory_epithelium0.91508961
91MP0004215_abnormal_myocardial_fiber0.90196861
92MP0003984_embryonic_growth_retardation0.86641678
93MP0008875_abnormal_xenobiotic_pharmacok0.86489038
94MP0008995_early_reproductive_senescence0.86384866
95MP0002405_respiratory_system_inflammati0.85403361
96MP0005332_abnormal_amino_acid0.85372086
97MP0008469_abnormal_protein_level0.84558449
98MP0002088_abnormal_embryonic_growth/wei0.83823689
99MP0000372_irregular_coat_pigmentation0.82888370
100MP0000653_abnormal_sex_gland0.82710674
101MP0001145_abnormal_male_reproductive0.81442954
102MP0002084_abnormal_developmental_patter0.81399205
103MP0005395_other_phenotype0.80670363
104MP0001881_abnormal_mammary_gland0.78710207
105MP0005408_hypopigmentation0.78023058
106MP0003011_delayed_dark_adaptation0.77545182
107MP0002638_abnormal_pupillary_reflex0.76289398
108MP0001845_abnormal_inflammatory_respons0.76149537
109MP0002282_abnormal_trachea_morphology0.76109887
110MP0001529_abnormal_vocalization0.74798345
111MP0002751_abnormal_autonomic_nervous0.73184480
112MP0002277_abnormal_respiratory_mucosa0.72088867
113MP0003646_muscle_fatigue0.72033001
114MP0000015_abnormal_ear_pigmentation0.71916420
115MP0000465_gastrointestinal_hemorrhage0.71775635
116MP0005376_homeostasis/metabolism_phenot0.70331887
117MP0005174_abnormal_tail_pigmentation0.70321840
118MP0002210_abnormal_sex_determination0.70268544
119MP0002160_abnormal_reproductive_system0.69828955
120MP0003890_abnormal_embryonic-extraembry0.69657434
121MP0003937_abnormal_limbs/digits/tail_de0.68982433
122MP0005410_abnormal_fertilization0.68452048
123MP0005389_reproductive_system_phenotype0.66959207
124MP0001119_abnormal_female_reproductive0.66564046
125MP0003121_genomic_imprinting0.66401698
126MP0005330_cardiomyopathy0.66352352
127MP0000343_altered_response_to0.66330461
128MP0005367_renal/urinary_system_phenotyp0.65622882
129MP0000516_abnormal_urinary_system0.65622882
130MP0001286_abnormal_eye_development0.65486354
131MP0005384_cellular_phenotype0.65386606
132MP0002085_abnormal_embryonic_tissue0.64537328
133MP0001727_abnormal_embryo_implantation0.64076195
134MP0008873_increased_physiological_sensi0.63968396
135MP0002086_abnormal_extraembryonic_tissu0.63855479
136MP0001986_abnormal_taste_sensitivity0.63751410
137MP0002006_tumorigenesis0.63471281
138MP0005636_abnormal_mineral_homeostasis0.62692211
139MP0001324_abnormal_eye_pigmentation0.59861175
140MP0001661_extended_life_span0.59690556
141MP0000749_muscle_degeneration0.58079250
142MP0005391_vision/eye_phenotype0.57742027
143MP0008872_abnormal_physiological_respon0.57534895
144MP0002233_abnormal_nose_morphology0.57231463
145MP0002234_abnormal_pharynx_morphology0.56890359
146MP0010030_abnormal_orbit_morphology0.55084684

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.69922004
2Abnormal number of erythroid precursors (HP:0012131)4.54133761
3Birth length less than 3rd percentile (HP:0003561)4.22021353
4Acute necrotizing encephalopathy (HP:0006965)4.08142806
5Reticulocytopenia (HP:0001896)4.01724563
6Abnormal mitochondria in muscle tissue (HP:0008316)3.90102178
7Hepatocellular necrosis (HP:0001404)3.81473196
8Mitochondrial inheritance (HP:0001427)3.80522140
9Aplastic anemia (HP:0001915)3.79638535
10Hepatic necrosis (HP:0002605)3.75504406
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74381463
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74381463
13Increased CSF lactate (HP:0002490)3.70047645
14Oral leukoplakia (HP:0002745)3.65790642
15Increased serum pyruvate (HP:0003542)3.43246641
16Abnormality of glycolysis (HP:0004366)3.43246641
17Increased serum lactate (HP:0002151)3.34970673
18Type I transferrin isoform profile (HP:0003642)3.31320852
19Breast hypoplasia (HP:0003187)3.30256907
20Acute encephalopathy (HP:0006846)3.29792681
21Abnormality of methionine metabolism (HP:0010901)3.23119585
22Increased hepatocellular lipid droplets (HP:0006565)3.16461162
23Progressive macrocephaly (HP:0004481)3.12913764
24Macrocytic anemia (HP:0001972)3.07617846
25Degeneration of anterior horn cells (HP:0002398)3.02032334
26Abnormality of the anterior horn cell (HP:0006802)3.02032334
27Rough bone trabeculation (HP:0100670)2.97800530
28Lipid accumulation in hepatocytes (HP:0006561)2.95639624
293-Methylglutaconic aciduria (HP:0003535)2.95089123
30Reduced antithrombin III activity (HP:0001976)2.93414465
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87194176
32Abnormality of alanine metabolism (HP:0010916)2.87194176
33Hyperalaninemia (HP:0003348)2.87194176
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86873418
35Pallor (HP:0000980)2.82688922
36Exercise intolerance (HP:0003546)2.82521610
37Multiple enchondromatosis (HP:0005701)2.78279067
38Lactic acidosis (HP:0003128)2.75424230
39Exertional dyspnea (HP:0002875)2.74662675
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71667028
41Microretrognathia (HP:0000308)2.66825651
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.65959980
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65835557
44Colon cancer (HP:0003003)2.60450928
45Cerebral hypomyelination (HP:0006808)2.58485965
46Agnosia (HP:0010524)2.55188048
47Respiratory difficulties (HP:0002880)2.53832443
48Methylmalonic acidemia (HP:0002912)2.52256442
49Increased intramyocellular lipid droplets (HP:0012240)2.52047075
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50950474
51Abnormal protein N-linked glycosylation (HP:0012347)2.50950474
52Abnormal protein glycosylation (HP:0012346)2.50950474
53Abnormal glycosylation (HP:0012345)2.50950474
54Methylmalonic aciduria (HP:0012120)2.50071569
55Carpal bone hypoplasia (HP:0001498)2.49185529
56Thrombocytosis (HP:0001894)2.49062847
57Cerebral edema (HP:0002181)2.48470026
58Leukodystrophy (HP:0002415)2.46294955
59Respiratory failure (HP:0002878)2.44820789
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44509380
61Nausea (HP:0002018)2.42861394
62IgM deficiency (HP:0002850)2.42486997
63Microvesicular hepatic steatosis (HP:0001414)2.35501435
64Premature graying of hair (HP:0002216)2.33579596
65Abnormality of serum amino acid levels (HP:0003112)2.31009072
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30506182
67Increased muscle lipid content (HP:0009058)2.29901167
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.29472384
69Optic disc pallor (HP:0000543)2.29394330
70Renal Fanconi syndrome (HP:0001994)2.29352865
71Pancytopenia (HP:0001876)2.27691865
72Abnormality of the preputium (HP:0100587)2.23461127
73Bone marrow hypocellularity (HP:0005528)2.19779903
74Abnormal trabecular bone morphology (HP:0100671)2.18057128
75Congenital, generalized hypertrichosis (HP:0004540)2.17128515
76Abnormality of placental membranes (HP:0011409)2.15017930
77Amniotic constriction ring (HP:0009775)2.15017930
7811 pairs of ribs (HP:0000878)2.14911386
79Poor head control (HP:0002421)2.14180841
80Patellar aplasia (HP:0006443)2.12977160
81Type 2 muscle fiber atrophy (HP:0003554)2.10686663
82Elevated erythrocyte sedimentation rate (HP:0003565)2.10152107
83Sparse eyelashes (HP:0000653)2.09661332
84Meckel diverticulum (HP:0002245)2.09373252
85CNS demyelination (HP:0007305)2.04760257
86Neoplasm of the adrenal gland (HP:0100631)2.03544455
87Abnormality of the labia minora (HP:0012880)2.02176933
88Muscle fiber atrophy (HP:0100295)2.02050702
89Aplasia/Hypoplasia of the patella (HP:0006498)2.01448607
90Cellular immunodeficiency (HP:0005374)2.01137341
91Generalized aminoaciduria (HP:0002909)1.99560968
92Myelodysplasia (HP:0002863)1.99427992
93Hypoglycemic coma (HP:0001325)1.98591734
94Abnormality of the ileum (HP:0001549)1.98212840
95Hyperglycinemia (HP:0002154)1.95617099
96Lymphoma (HP:0002665)1.93535479
97Selective tooth agenesis (HP:0001592)1.92728600
98Palpitations (HP:0001962)1.92106297
99Absent thumb (HP:0009777)1.91932180
100Posterior subcapsular cataract (HP:0007787)1.91108735
101Dicarboxylic aciduria (HP:0003215)1.89990823
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89990823
103Abnormality of chromosome stability (HP:0003220)1.89936047
104Megaloblastic anemia (HP:0001889)1.89255096
105Emotional lability (HP:0000712)1.89035889
106Trismus (HP:0000211)1.88615713
107Cleft eyelid (HP:0000625)1.88349752
108Neoplasm of the colon (HP:0100273)1.87763577
109Abnormality of the duodenum (HP:0002246)1.87670366
110Postnatal microcephaly (HP:0005484)1.86136827
111Petechiae (HP:0000967)1.85185455
112Chromsome breakage (HP:0040012)1.83651178
113Abnormality of sulfur amino acid metabolism (HP:0004339)1.82557021
114Neoplasm of the pancreas (HP:0002894)1.78797727
115Secondary amenorrhea (HP:0000869)1.78788894
116Small intestinal stenosis (HP:0012848)1.77853121
117Duodenal stenosis (HP:0100867)1.77853121
118X-linked dominant inheritance (HP:0001423)1.76948607
119Bifid tongue (HP:0010297)1.76571047
120Lethargy (HP:0001254)1.75816315
121IgG deficiency (HP:0004315)1.75494766
122Abnormality of renal resorption (HP:0011038)1.74944920
123Pancreatic islet-cell hyperplasia (HP:0004510)1.72760952
124Glossoptosis (HP:0000162)1.71646667
125Abnormality of urine glucose concentration (HP:0011016)1.71018981
126Glycosuria (HP:0003076)1.71018981
127Abnormal spermatogenesis (HP:0008669)1.69089197
128Dyschromatopsia (HP:0007641)1.67893232
129Progressive muscle weakness (HP:0003323)1.67734224
130Abnormal lung lobation (HP:0002101)1.67670716
131Median cleft lip (HP:0000161)1.66997813
132Rhabdomyosarcoma (HP:0002859)1.65799953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.84398007
2WEE13.98840261
3EIF2AK13.90787349
4STK163.85854217
5VRK23.59098591
6NME22.99649190
7EIF2AK32.98082269
8CDC72.65243499
9TRIM282.55695878
10NEK12.50080499
11VRK12.37995232
12SRPK12.29616851
13ACVR1B2.24851544
14TSSK62.06463161
15PLK42.01631560
16PDK21.95422815
17BRSK21.92191280
18TESK21.71523099
19PBK1.68189839
20NUAK11.67881939
21PIM21.67369664
22PASK1.49298435
23CCNB11.48455795
24NEK21.47395490
25PLK11.39977550
26DYRK31.38775097
27NME11.37881822
28CDK191.36158615
29MST41.35947823
30BCR1.35916439
31MKNK11.33372795
32BCKDK1.32403729
33AURKB1.29724056
34PLK31.23331134
35KDR1.22514533
36ZAK1.19880057
37RPS6KA41.19357384
38MAP4K21.18752593
39SCYL21.18437817
40TGFBR11.18150531
41TTK1.15442813
42EIF2AK21.15330150
43BRSK11.10540461
44RPS6KB21.09777916
45TESK11.09549438
46ATR1.08518883
47CDK71.07380443
48TLK11.07322909
49AURKA1.06067883
50IRAK41.03232347
51WNK31.00039889
52TEC0.99382390
53CDK80.98708440
54CSNK1G30.97647482
55BMPR1B0.95739007
56FLT30.95378763
57MAP3K120.94312361
58CSNK1G10.92678341
59TAF10.91528783
60MYLK0.87653193
61BMPR20.86217471
62PLK20.81365197
63PAK40.81075134
64MAP3K80.81064341
65STK40.79851646
66BLK0.79237116
67MAP4K10.78819282
68ABL20.77789349
69KIT0.76988987
70ERBB40.75733967
71CSNK1A1L0.75184398
72CSNK2A10.74602444
73MAP3K110.73005165
74BTK0.71229262
75BRAF0.70996519
76CSNK1G20.70907367
77LIMK10.69462820
78CHEK20.68218076
79LRRK20.66459626
80CDK40.66368191
81EPHA20.65143883
82TAOK20.64341990
83PIM10.64027212
84CSNK2A20.63981968
85MST1R0.62993052
86IRAK30.62719640
87ARAF0.61765743
88MKNK20.60055610
89ZAP700.59582980
90TYK20.57821496
91SIK30.57716494
92PDK30.57010359
93PDK40.57010359
94DYRK20.56664625
95TBK10.56189901
96DAPK10.55688929
97PAK10.54888133
98CHEK10.54472874
99ILK0.53952692
100GRK10.53748206
101INSRR0.53136815
102CLK10.52558191
103STK100.51925309
104NEK90.51805740
105TNIK0.51583370
106OBSCN0.50053051
107YES10.49675691
108STK30.48563510
109MAP2K30.47821212
110LYN0.47804976
111ATM0.46651194
112SYK0.44267091
113OXSR10.44153891
114STK240.43695350
115TXK0.41835700
116RPS6KA50.40977488
117ERBB30.40382681
118STK38L0.40291038
119JAK30.40253467
120ALK0.40055032
121PRKCI0.39519594
122FGFR10.39186031
123IKBKB0.37124533
124ADRBK20.36284539
125CSF1R0.34105123
126MAP3K40.33852628
127MAPKAPK30.33275434
128RAF10.31948020
129CAMKK20.31730165
130CDK30.30295200
131FER0.29454568
132MAPKAPK50.26368125
133MINK10.23312157
134DAPK30.21894415

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030504.89067664
2DNA replication_Homo sapiens_hsa030304.55445628
3Ribosome_Homo sapiens_hsa030104.01566311
4Mismatch repair_Homo sapiens_hsa034303.69562576
5RNA polymerase_Homo sapiens_hsa030203.27268609
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88948232
7Spliceosome_Homo sapiens_hsa030402.77466264
8Pyrimidine metabolism_Homo sapiens_hsa002402.65419104
9Base excision repair_Homo sapiens_hsa034102.63688064
10Nucleotide excision repair_Homo sapiens_hsa034202.61017550
11Homologous recombination_Homo sapiens_hsa034402.60817340
12RNA transport_Homo sapiens_hsa030132.34433061
13Oxidative phosphorylation_Homo sapiens_hsa001902.07848584
14Protein export_Homo sapiens_hsa030602.06515596
15Parkinsons disease_Homo sapiens_hsa050122.00242250
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91114091
17Cell cycle_Homo sapiens_hsa041101.85351543
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78629378
19One carbon pool by folate_Homo sapiens_hsa006701.73412667
20Non-homologous end-joining_Homo sapiens_hsa034501.65591273
21Basal transcription factors_Homo sapiens_hsa030221.62784431
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62234012
23Huntingtons disease_Homo sapiens_hsa050161.54378746
24RNA degradation_Homo sapiens_hsa030181.52934679
25Fanconi anemia pathway_Homo sapiens_hsa034601.50742631
26Purine metabolism_Homo sapiens_hsa002301.42413590
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40377877
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28296048
29Pentose phosphate pathway_Homo sapiens_hsa000301.18781646
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17431973
31Folate biosynthesis_Homo sapiens_hsa007901.15282423
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13494760
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11907627
34Sulfur metabolism_Homo sapiens_hsa009201.11836140
35Steroid biosynthesis_Homo sapiens_hsa001001.11729538
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11533121
37Epstein-Barr virus infection_Homo sapiens_hsa051691.10528614
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08862126
39Alzheimers disease_Homo sapiens_hsa050101.08327383
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.06951630
41p53 signaling pathway_Homo sapiens_hsa041151.06508649
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.02810099
43Legionellosis_Homo sapiens_hsa051340.97125530
44Carbon metabolism_Homo sapiens_hsa012000.96048727
45Biosynthesis of amino acids_Homo sapiens_hsa012300.88634320
46Glutathione metabolism_Homo sapiens_hsa004800.88518660
47Systemic lupus erythematosus_Homo sapiens_hsa053220.88051085
48Antigen processing and presentation_Homo sapiens_hsa046120.86188244
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80732356
50mRNA surveillance pathway_Homo sapiens_hsa030150.76624412
51Sulfur relay system_Homo sapiens_hsa041220.76178345
52Herpes simplex infection_Homo sapiens_hsa051680.74453023
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69423258
54Butanoate metabolism_Homo sapiens_hsa006500.64274679
55N-Glycan biosynthesis_Homo sapiens_hsa005100.63303298
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60276716
57Fructose and mannose metabolism_Homo sapiens_hsa000510.57919311
58Metabolic pathways_Homo sapiens_hsa011000.57263231
59Primary immunodeficiency_Homo sapiens_hsa053400.56693639
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56259464
61Collecting duct acid secretion_Homo sapiens_hsa049660.55957091
62Fatty acid metabolism_Homo sapiens_hsa012120.55361372
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.54471816
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54174710
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53897069
66Selenocompound metabolism_Homo sapiens_hsa004500.52952903
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50714937
68Galactose metabolism_Homo sapiens_hsa000520.49676567
69Allograft rejection_Homo sapiens_hsa053300.48699917
70Pyruvate metabolism_Homo sapiens_hsa006200.48306759
71Viral carcinogenesis_Homo sapiens_hsa052030.47882107
72Regulation of autophagy_Homo sapiens_hsa041400.46755391
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46058182
74Tryptophan metabolism_Homo sapiens_hsa003800.46018379
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43664930
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.43513164
77Fatty acid degradation_Homo sapiens_hsa000710.41898030
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40985827
79Graft-versus-host disease_Homo sapiens_hsa053320.39493121
80Oocyte meiosis_Homo sapiens_hsa041140.37440652
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36627741
82Measles_Homo sapiens_hsa051620.35773476
83Renin-angiotensin system_Homo sapiens_hsa046140.35668000
84Asthma_Homo sapiens_hsa053100.35114901
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33778926
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32900753
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.32396646
88Vitamin B6 metabolism_Homo sapiens_hsa007500.31412322
89Shigellosis_Homo sapiens_hsa051310.31323928
90Chemical carcinogenesis_Homo sapiens_hsa052040.30844176
91Nitrogen metabolism_Homo sapiens_hsa009100.30174338
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30103099
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29118020
94Type I diabetes mellitus_Homo sapiens_hsa049400.28968763
95Hematopoietic cell lineage_Homo sapiens_hsa046400.28113067
96Apoptosis_Homo sapiens_hsa042100.27874679
97Rheumatoid arthritis_Homo sapiens_hsa053230.27414156
98Vitamin digestion and absorption_Homo sapiens_hsa049770.27258191
99Vibrio cholerae infection_Homo sapiens_hsa051100.26169243
100Caffeine metabolism_Homo sapiens_hsa002320.25998201
101Arachidonic acid metabolism_Homo sapiens_hsa005900.25838303
102Cardiac muscle contraction_Homo sapiens_hsa042600.25795043
103Propanoate metabolism_Homo sapiens_hsa006400.25146000
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24279267
105HTLV-I infection_Homo sapiens_hsa051660.24220866
106Peroxisome_Homo sapiens_hsa041460.23266715
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.22932522
108beta-Alanine metabolism_Homo sapiens_hsa004100.22246412
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21752967
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20973503
111Thyroid cancer_Homo sapiens_hsa052160.20759746
112Other glycan degradation_Homo sapiens_hsa005110.19104872
113Fatty acid elongation_Homo sapiens_hsa000620.18174918
114Leishmaniasis_Homo sapiens_hsa051400.17490977
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17470877
116Phenylalanine metabolism_Homo sapiens_hsa003600.17033297
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16707165
118Phagosome_Homo sapiens_hsa041450.16520087
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16507430
120Autoimmune thyroid disease_Homo sapiens_hsa053200.16307538
121Retinol metabolism_Homo sapiens_hsa008300.15104059
122Arginine and proline metabolism_Homo sapiens_hsa003300.14547196
123Alcoholism_Homo sapiens_hsa050340.14194015
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14166445
125Tyrosine metabolism_Homo sapiens_hsa003500.14141485

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