PSKH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesoderm development (GO:2000380)6.35841963
2cardiac epithelial to mesenchymal transition (GO:0060317)6.35204503
3renal absorption (GO:0070293)6.16426998
4anterior/posterior axis specification (GO:0009948)6.02740721
5cell migration involved in gastrulation (GO:0042074)5.74665901
6primitive streak formation (GO:0090009)5.71121567
7sequestering of extracellular ligand from receptor (GO:0035581)5.69494143
8cell surface receptor signaling pathway involved in heart development (GO:0061311)5.57140356
9endoderm formation (GO:0001706)5.42681090
10negative regulation of axon extension involved in axon guidance (GO:0048843)5.33014667
11negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.23775217
12somite rostral/caudal axis specification (GO:0032525)5.17014066
13gastrulation (GO:0007369)5.06151026
14signal transduction involved in regulation of gene expression (GO:0023019)4.86733405
15negative regulation of striated muscle cell apoptotic process (GO:0010664)4.85830372
16regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.82636757
17regulation of activin receptor signaling pathway (GO:0032925)4.81230973
18anterior/posterior axis specification, embryo (GO:0008595)4.75547219
19ventricular cardiac muscle cell development (GO:0055015)4.74837512
20regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.61770924
21negative regulation of activin receptor signaling pathway (GO:0032926)4.54292067
22regulation of DNA-templated transcription, initiation (GO:2000142)4.53271165
23positive regulation of catenin import into nucleus (GO:0035413)4.44065354
24Notch signaling involved in heart development (GO:0061314)4.36365834
25phospholipid scrambling (GO:0017121)4.33834326
26response to BMP (GO:0071772)4.33032823
27cellular response to BMP stimulus (GO:0071773)4.33032823
28negative regulation of axon guidance (GO:1902668)4.18300196
29CENP-A containing nucleosome assembly (GO:0034080)4.16548791
30negative regulation of smooth muscle cell differentiation (GO:0051151)4.13223891
31positive regulation of DNA-templated transcription, initiation (GO:2000144)4.10514292
32positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.05314205
33chromatin remodeling at centromere (GO:0031055)3.96839703
34embryonic axis specification (GO:0000578)3.89914402
35regulation of cardiac muscle cell apoptotic process (GO:0010665)3.86942106
36DNA replication-dependent nucleosome assembly (GO:0006335)3.85208346
37DNA replication-dependent nucleosome organization (GO:0034723)3.85208346
38cardiac right ventricle morphogenesis (GO:0003215)3.83638674
39regulation of smooth muscle cell differentiation (GO:0051150)3.81935255
40glomerulus development (GO:0032835)3.75669388
41regulation of striated muscle cell apoptotic process (GO:0010662)3.72036829
42positive regulation of SMAD protein import into nucleus (GO:0060391)3.70825731
43mesenchymal cell development (GO:0014031)3.69104499
44gastrulation with mouth forming second (GO:0001702)3.66156517
45mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.63579607
46regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.62847523
47epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.62065896
48SMAD protein signal transduction (GO:0060395)3.61039592
49axis specification (GO:0009798)3.60835484
50positive regulation of urine volume (GO:0035810)3.57022371
51regulation of homotypic cell-cell adhesion (GO:0034110)3.51154664
52cochlea development (GO:0090102)3.50337289
53lateral sprouting from an epithelium (GO:0060601)3.46443949
54kidney mesenchyme development (GO:0072074)3.44681931
55fat-soluble vitamin catabolic process (GO:0042363)3.43110757
56vitamin catabolic process (GO:0009111)3.43110757
57histone exchange (GO:0043486)3.42398550
58cellular response to fluid shear stress (GO:0071498)3.42106290
59meiotic chromosome segregation (GO:0045132)3.41976659
60metaphase plate congression (GO:0051310)3.39436849
61epithelial to mesenchymal transition (GO:0001837)3.38258968
62type B pancreatic cell development (GO:0003323)3.38232103
63negative regulation of embryonic development (GO:0045992)3.37384117
64regulation of centrosome duplication (GO:0010824)3.35180771
65telencephalon development (GO:0021537)3.33504808
66female gonad development (GO:0008585)3.32730763
67regulation of centrosome cycle (GO:0046605)3.32396317
68regulation of centriole replication (GO:0046599)3.20849183
69DNA double-strand break processing (GO:0000729)3.16563435
70embryonic foregut morphogenesis (GO:0048617)3.15974921
71smooth muscle cell differentiation (GO:0051145)3.15031756
72dorsal/ventral axis specification (GO:0009950)3.14473380
73mesenchymal cell differentiation (GO:0048762)3.14398444
74cardiac muscle hypertrophy in response to stress (GO:0014898)3.13964148
75muscle hypertrophy in response to stress (GO:0003299)3.13964148
76cardiac muscle adaptation (GO:0014887)3.13964148
77DNA replication-independent nucleosome assembly (GO:0006336)3.12517192
78DNA replication-independent nucleosome organization (GO:0034724)3.12517192
79cardiac left ventricle morphogenesis (GO:0003214)3.11733768
80positive regulation of cardiac muscle tissue development (GO:0055025)3.09531811
81positive regulation of cardiac muscle cell proliferation (GO:0060045)3.08664649
82uterus development (GO:0060065)3.08074076
83atrial cardiac muscle cell action potential (GO:0086014)3.06644364
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05560586
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05560586
86isotype switching (GO:0045190)3.05560586
87metanephric mesenchyme development (GO:0072075)3.04576647
88pattern specification involved in kidney development (GO:0061004)3.04365121
89heart valve formation (GO:0003188)3.04062102
90bone morphogenesis (GO:0060349)3.02909925
91ventricular trabecula myocardium morphogenesis (GO:0003222)3.02475251
92extracellular negative regulation of signal transduction (GO:1900116)3.02247536
93extracellular regulation of signal transduction (GO:1900115)3.02247536
94organ formation (GO:0048645)3.01324042
95DNA replication checkpoint (GO:0000076)3.01290837
96regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.00462515
97regulation of axon extension involved in axon guidance (GO:0048841)2.98215998
98positive regulation of meiosis (GO:0045836)2.97591830
99positive regulation of p38MAPK cascade (GO:1900745)2.97399167
100mesenchymal to epithelial transition (GO:0060231)2.96181240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.27612453
2E2F7_22180533_ChIP-Seq_HELA_Human3.70200161
3EWS_26573619_Chip-Seq_HEK293_Human2.75181090
4VDR_22108803_ChIP-Seq_LS180_Human2.73645251
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.72275765
6AR_21909140_ChIP-Seq_LNCAP_Human2.65183248
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.59267962
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58448927
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57703149
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48151866
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.46271685
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.46271685
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.46271685
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.43822064
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37652404
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27679846
17ELK1_19687146_ChIP-ChIP_HELA_Human2.27000925
18SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.18911300
19* SMAD3_21741376_ChIP-Seq_HESCs_Human2.18881210
20SMAD3_21741376_ChIP-Seq_EPCs_Human2.17339179
21TAF15_26573619_Chip-Seq_HEK293_Human2.13290898
22P300_19829295_ChIP-Seq_ESCs_Human2.08617524
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00936874
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96655818
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.91269973
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89646472
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83303776
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83265263
29FUS_26573619_Chip-Seq_HEK293_Human1.78637422
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76080712
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.75697231
32SMAD4_21741376_ChIP-Seq_HESCs_Human1.75589422
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.75302150
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73893567
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72618393
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.68617125
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65719987
38RNF2_27304074_Chip-Seq_NSC_Mouse1.63900277
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62743753
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62260861
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61402934
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.60233681
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.54177431
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52425523
45* SMAD4_21741376_ChIP-Seq_EPCs_Human1.49611076
46BCAT_22108803_ChIP-Seq_LS180_Human1.49237879
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.48995334
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.48019507
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46967081
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46940234
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45828882
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.43721706
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40069105
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39472495
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39221680
56TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38883486
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36107048
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33740732
59ZNF274_21170338_ChIP-Seq_K562_Hela1.33332722
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31434358
61* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30420366
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28307327
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24207969
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24055860
65CBP_20019798_ChIP-Seq_JUKART_Human1.24055860
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20685850
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16994168
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14547618
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.14399210
70GBX2_23144817_ChIP-Seq_PC3_Human1.14127134
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13610870
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.13500006
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12440298
74MYC_18940864_ChIP-ChIP_HL60_Human1.10644204
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.10207788
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.09760251
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.09304937
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08525900
79EOMES_21245162_ChIP-Seq_HESCs_Human1.08122366
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07179926
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07179926
82TCF4_22108803_ChIP-Seq_LS180_Human1.06935857
83AR_25329375_ChIP-Seq_VCAP_Human1.06741903
84CDX2_22108803_ChIP-Seq_LS180_Human1.06176766
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04436435
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03472125
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03194436
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01741644
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01649818
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01225490
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.01026617
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00099860
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00017843
94RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00017843
95LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99849326
96RUNX2_22187159_ChIP-Seq_PCA_Human0.99117425
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98999082
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98992846
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.98093965
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.97942608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry6.96724855
2MP0003119_abnormal_digestive_system4.51971468
3MP0009053_abnormal_anal_canal3.76227420
4MP0003195_calcinosis3.44029746
5MP0000537_abnormal_urethra_morphology3.38681328
6MP0003937_abnormal_limbs/digits/tail_de3.11660291
7MP0009384_cardiac_valve_regurgitation3.07357005
8MP0000516_abnormal_urinary_system2.88137858
9MP0005367_renal/urinary_system_phenotyp2.88137858
10MP0000462_abnormal_digestive_system2.26129735
11MP0002009_preneoplasia2.09325254
12MP0006054_spinal_hemorrhage2.06655886
13MP0002127_abnormal_cardiovascular_syste1.99791828
14MP0002084_abnormal_developmental_patter1.95356243
15MP0004957_abnormal_blastocyst_morpholog1.95291009
16MP0003385_abnormal_body_wall1.88512675
17MP0008932_abnormal_embryonic_tissue1.87622173
18MP0010030_abnormal_orbit_morphology1.86306320
19MP0010094_abnormal_chromosome_stability1.86154588
20MP0002160_abnormal_reproductive_system1.84052117
21MP0000534_abnormal_ureter_morphology1.81600738
22MP0002102_abnormal_ear_morphology1.75931543
23MP0003279_aneurysm1.75484361
24MP0005423_abnormal_somatic_nervous1.69400917
25MP0004215_abnormal_myocardial_fiber1.69217008
26MP0006072_abnormal_retinal_apoptosis1.65400495
27MP0001730_embryonic_growth_arrest1.65375348
28MP0004133_heterotaxia1.62174472
29MP0001672_abnormal_embryogenesis/_devel1.61475697
30MP0005380_embryogenesis_phenotype1.61475697
31MP0002111_abnormal_tail_morphology1.56438066
32MP0001293_anophthalmia1.54718298
33MP0009250_abnormal_appendicular_skeleto1.53783859
34MP0008057_abnormal_DNA_replication1.52192808
35MP0001485_abnormal_pinna_reflex1.50816314
36MP0003567_abnormal_fetal_cardiomyocyte1.45313833
37MP0008058_abnormal_DNA_repair1.41711171
38MP0002233_abnormal_nose_morphology1.41442766
39MP0002932_abnormal_joint_morphology1.41014216
40MP0000049_abnormal_middle_ear1.40774801
41MP0003941_abnormal_skin_development1.37648409
42MP0003943_abnormal_hepatobiliary_system1.37506745
43MP0002277_abnormal_respiratory_mucosa1.36552520
44MP0002085_abnormal_embryonic_tissue1.31721833
45MP0003984_embryonic_growth_retardation1.26129092
46MP0002088_abnormal_embryonic_growth/wei1.23421346
47MP0004085_abnormal_heartbeat1.19882958
48MP0008995_early_reproductive_senescence1.19529235
49MP0001286_abnormal_eye_development1.14544066
50MP0002332_abnormal_exercise_endurance1.13312609
51MP0003935_abnormal_craniofacial_develop1.12192846
52MP0008789_abnormal_olfactory_epithelium1.11659753
53MP0000538_abnormal_urinary_bladder1.11064579
54MP0005389_reproductive_system_phenotype1.10052459
55MP0000428_abnormal_craniofacial_morphol1.06812213
56MP0003880_abnormal_central_pattern1.05011041
57MP0002109_abnormal_limb_morphology1.03518063
58MP0003936_abnormal_reproductive_system1.02915246
59MP0000767_abnormal_smooth_muscle1.02072565
60MP0001346_abnormal_lacrimal_gland1.01899577
61MP0000762_abnormal_tongue_morphology0.99499856
62MP0003942_abnormal_urinary_system0.96767834
63MP0001529_abnormal_vocalization0.95352236
64MP0000631_abnormal_neuroendocrine_gland0.93711627
65MP0003077_abnormal_cell_cycle0.92667291
66MP0002254_reproductive_system_inflammat0.91628115
67MP0005499_abnormal_olfactory_system0.91600874
68MP0005394_taste/olfaction_phenotype0.91600874
69MP0005620_abnormal_muscle_contractility0.89385158
70MP0003137_abnormal_impulse_conducting0.88530268
71MP0002086_abnormal_extraembryonic_tissu0.88222313
72MP0004510_myositis0.86917082
73MP0005197_abnormal_uvea_morphology0.86799627
74MP0005647_abnormal_sex_gland0.85430903
75MP0002925_abnormal_cardiovascular_devel0.84248428
76MP0005391_vision/eye_phenotype0.83266585
77MP0003693_abnormal_embryo_hatching0.82916122
78MP0001697_abnormal_embryo_size0.81094162
79MP0005084_abnormal_gallbladder_morpholo0.80597266
80MP0000470_abnormal_stomach_morphology0.79501319
81MP0000163_abnormal_cartilage_morphology0.77035681
82MP0000350_abnormal_cell_proliferation0.76747061
83MP0000432_abnormal_head_morphology0.76236527
84MP0002092_abnormal_eye_morphology0.76058180
85MP0002697_abnormal_eye_size0.74885738
86MP0005253_abnormal_eye_physiology0.74811112
87MP0002736_abnormal_nociception_after0.73796377
88MP0003861_abnormal_nervous_system0.72933639
89MP0004272_abnormal_basement_membrane0.72067523
90MP0002115_abnormal_skeleton_extremities0.71509821
91MP0000230_abnormal_systemic_arterial0.70673834
92MP0004145_abnormal_muscle_electrophysio0.70025280
93MP0005595_abnormal_vascular_smooth0.68888902
94MP0003566_abnormal_cell_adhesion0.67087342
95MP0009703_decreased_birth_body0.67065437
96MP0002282_abnormal_trachea_morphology0.66763498
97MP0005330_cardiomyopathy0.64723968
98MP0004742_abnormal_vestibular_system0.64633117
99MP0002080_prenatal_lethality0.62019816
100MP0001119_abnormal_female_reproductive0.61435182

Predicted human phenotypes

RankGene SetZ-score
1Single umbilical artery (HP:0001195)5.05176381
2Abnormality of the fetal cardiovascular system (HP:0010948)5.05176381
3Abnormal umbilical cord blood vessels (HP:0011403)5.05176381
4Short middle phalanx of the 5th finger (HP:0004220)5.03803673
5Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.45379638
6Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.33298093
7Abnormal pancreas size (HP:0012094)4.32187488
8Posterior subcapsular cataract (HP:0007787)4.17978763
9Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.07727386
10Abnormality of the phalanges of the 5th finger (HP:0004213)4.01887702
11Colon cancer (HP:0003003)3.61625386
12Chorioretinal atrophy (HP:0000533)3.36566787
13Abnormality of the umbilical cord (HP:0010881)3.28932818
14Gonadotropin excess (HP:0000837)3.22304787
15Short hallux (HP:0010109)3.14207940
16Abnormality of the ischium (HP:0003174)3.09868267
17Aplasia/Hypoplasia of the spleen (HP:0010451)3.04095838
18Asplenia (HP:0001746)3.00654207
19Hypoplastic pelvis (HP:0008839)2.98915213
20Rectovaginal fistula (HP:0000143)2.86720515
21Rectal fistula (HP:0100590)2.86720515
22Embryonal renal neoplasm (HP:0011794)2.85485296
23Aplasia/Hypoplasia of the hallux (HP:0008362)2.83118328
24Bifid tongue (HP:0010297)2.82192909
25Abnormal lung lobation (HP:0002101)2.80953251
26Abdominal situs inversus (HP:0003363)2.73125270
27Abnormality of abdominal situs (HP:0011620)2.73125270
28Mesomelia (HP:0003027)2.66517589
29Intestinal atresia (HP:0011100)2.62391172
30Anal stenosis (HP:0002025)2.59689010
31Hyperglycemia (HP:0003074)2.58967151
32Preaxial foot polydactyly (HP:0001841)2.56390450
33Increased serum pyruvate (HP:0003542)2.56202274
34Congenital, generalized hypertrichosis (HP:0004540)2.55652968
35Supernumerary spleens (HP:0009799)2.53636214
36Intestinal fistula (HP:0100819)2.50906205
37Abnormality of the right ventricle (HP:0001707)2.50890611
38Medulloblastoma (HP:0002885)2.49543576
39Abnormality of the parathyroid morphology (HP:0011766)2.49179612
40Abnormal vertebral ossification (HP:0100569)2.49057501
41Periauricular skin pits (HP:0100277)2.47617883
42Preauricular pit (HP:0004467)2.47617883
43Hypoplastic labia majora (HP:0000059)2.45686122
44Vaginal fistula (HP:0004320)2.45123836
45Septate vagina (HP:0001153)2.42327395
46Volvulus (HP:0002580)2.39434137
47Septo-optic dysplasia (HP:0100842)2.38513862
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35845040
49Gonadal dysgenesis (HP:0000133)2.35408287
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.27775183
51Proximal placement of thumb (HP:0009623)2.26757862
52Delayed CNS myelination (HP:0002188)2.26648137
53Cortical dysplasia (HP:0002539)2.24787903
54Birth length less than 3rd percentile (HP:0003561)2.23852160
55Short tibia (HP:0005736)2.23063985
56Abnormality of chromosome stability (HP:0003220)2.22390688
57Short humerus (HP:0005792)2.21628036
58Abnormality of the labia majora (HP:0012881)2.21172402
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.20926056
60Subcapsular cataract (HP:0000523)2.16879484
61Anal atresia (HP:0002023)2.15234453
62Short middle phalanx of finger (HP:0005819)2.14828077
63Neoplasm of the adrenal cortex (HP:0100641)2.14593578
64Short 5th finger (HP:0009237)2.14327555
65Type I diabetes mellitus (HP:0100651)2.13737034
66Congenital malformation of the right heart (HP:0011723)2.12782518
67Double outlet right ventricle (HP:0001719)2.12782518
68Aplasia/hypoplasia of the humerus (HP:0006507)2.09070878
69Deviation of the thumb (HP:0009603)2.08357201
70Abnormality of the musculature of the pelvis (HP:0001469)2.00916604
71Abnormality of the hip-girdle musculature (HP:0001445)2.00916604
72Tetraparesis (HP:0002273)1.98364581
73Focal segmental glomerulosclerosis (HP:0000097)1.98002444
74Neoplasm of the liver (HP:0002896)1.97594796
75Abnormalities of placenta or umbilical cord (HP:0001194)1.97296942
76Abnormality of glycolysis (HP:0004366)1.94710232
77Anencephaly (HP:0002323)1.94074795
78Missing ribs (HP:0000921)1.93423902
79Myelomeningocele (HP:0002475)1.92676276
80Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.92655875
81Oral leukoplakia (HP:0002745)1.92407611
82Absent radius (HP:0003974)1.91353027
83Ependymoma (HP:0002888)1.91287064
84Optic nerve coloboma (HP:0000588)1.88939628
85Increased number of teeth (HP:0011069)1.88610304
86Hypoplastic ischia (HP:0003175)1.86755471
87Small hand (HP:0200055)1.85771157
88Neoplasm of the adrenal gland (HP:0100631)1.84197945
89Meckel diverticulum (HP:0002245)1.82559601
90Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82153492
91Midline defect of the nose (HP:0004122)1.81736739
92Skin pits (HP:0100276)1.81653153
93Labial hypoplasia (HP:0000066)1.80856175
94Abnormality of the ileum (HP:0001549)1.80849041
95Disproportionate short-trunk short stature (HP:0003521)1.79462085
96Ectopic anus (HP:0004397)1.78400855
97Abnormality of the middle phalanges of the hand (HP:0009833)1.78163108
98Aplasia involving forearm bones (HP:0009822)1.77621178
99Absent forearm bone (HP:0003953)1.77621178
100Hypoplastic left heart (HP:0004383)1.76322812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.27347522
2TAF13.94412915
3ACVR1B3.82449909
4MST43.78858292
5TSSK63.57406533
6PNCK3.43492216
7MAP3K103.30419135
8MKNK23.20526471
9WNK33.03456993
10VRK22.70069595
11ERBB42.60328184
12BMPR1B2.54867349
13NUAK12.48454572
14WEE12.47124476
15PBK2.36041129
16MKNK12.23180248
17BRSK22.11221531
18TGFBR12.08306718
19VRK12.01358573
20DYRK1B2.01352538
21TTK1.96778878
22PLK31.79549814
23MAP3K41.68487710
24MAP4K21.64900534
25TRIM281.36412356
26MELK1.28327682
27MAP3K121.27965208
28PLK21.23237136
29PASK1.21161349
30CHEK21.04632112
31LATS11.02348186
32BRAF1.01934405
33LATS21.01419341
34TNIK0.98780986
35SRPK10.95943404
36MAPK150.84224256
37STK390.84059410
38NEK10.82779901
39PRKAA20.81484601
40STK100.80362017
41EIF2AK20.79895910
42EPHA40.78493636
43YES10.77114458
44EIF2AK30.76660804
45PLK10.75446681
46ERBB30.73378364
47OBSCN0.70069053
48NLK0.69971284
49ADRBK10.68131563
50STK38L0.63534477
51BUB10.59790465
52CAMKK20.57995939
53ADRBK20.57450408
54CDC70.57135961
55PKN20.56500293
56OXSR10.54366825
57BCR0.53174394
58AURKB0.52914327
59BRSK10.52164788
60CDK190.51827223
61IRAK20.50706884
62EPHB20.50572111
63ATR0.50344262
64STK30.46042283
65ZAK0.43772846
66ALK0.42763874
67AKT30.42713569
68FLT30.38733639
69CASK0.38158246
70PDGFRA0.35093963
71ROCK20.34643372
72ATM0.34529055
73CSNK1G10.34001760
74PAK20.33789730
75IRAK40.32553797
76PDGFRB0.30750338
77TGFBR20.30061981
78FGFR10.29371872
79WNK40.28656268
80DMPK0.27349725
81CDK60.27061616
82IRAK10.26750809
83PRKCG0.24700446
84CHEK10.24065165
85DAPK10.22082613
86PRKCD0.21335994
87CSNK1E0.20690772
88GRK50.20082391
89CDK30.19597201
90PDK20.18715519
91STK40.16891471
92CSNK1D0.15708547
93FGR0.15512017
94GSK3A0.15257447
95CSNK1G20.15057736
96PRKCE0.14607856
97CAMK1D0.14189053
98PRKG10.13938303
99AURKA0.13227885
100MAP2K20.12421285

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.91616622
2Basal transcription factors_Homo sapiens_hsa030223.06771443
3Basal cell carcinoma_Homo sapiens_hsa052172.96514596
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62080679
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.54333820
6Hedgehog signaling pathway_Homo sapiens_hsa043402.52566638
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41596688
8TGF-beta signaling pathway_Homo sapiens_hsa043502.31159230
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29640501
10Mismatch repair_Homo sapiens_hsa034302.28863197
11Selenocompound metabolism_Homo sapiens_hsa004502.26966271
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.26058399
13Fanconi anemia pathway_Homo sapiens_hsa034602.15947189
14DNA replication_Homo sapiens_hsa030302.09336148
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01468637
16RNA degradation_Homo sapiens_hsa030181.98766156
17Cell cycle_Homo sapiens_hsa041101.98047770
18Homologous recombination_Homo sapiens_hsa034401.95606586
19Proteasome_Homo sapiens_hsa030501.93144252
20RNA transport_Homo sapiens_hsa030131.92450678
21Wnt signaling pathway_Homo sapiens_hsa043101.90202708
22Steroid biosynthesis_Homo sapiens_hsa001001.86947883
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81051258
24Protein export_Homo sapiens_hsa030601.76293836
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50122679
26Propanoate metabolism_Homo sapiens_hsa006401.48778859
27Spliceosome_Homo sapiens_hsa030401.39582633
28Hippo signaling pathway_Homo sapiens_hsa043901.37693634
29Caffeine metabolism_Homo sapiens_hsa002321.35738300
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22836884
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18201942
32Pyruvate metabolism_Homo sapiens_hsa006201.13041920
33Sulfur metabolism_Homo sapiens_hsa009201.07018544
34Fatty acid elongation_Homo sapiens_hsa000621.06291503
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.05188463
36Fatty acid metabolism_Homo sapiens_hsa012121.04706625
37Legionellosis_Homo sapiens_hsa051341.01878399
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98435453
39Purine metabolism_Homo sapiens_hsa002300.96538111
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.93615342
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93207778
42Tryptophan metabolism_Homo sapiens_hsa003800.92492060
43Base excision repair_Homo sapiens_hsa034100.89248140
44Olfactory transduction_Homo sapiens_hsa047400.85456925
45Nucleotide excision repair_Homo sapiens_hsa034200.84299661
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83008400
47Retinol metabolism_Homo sapiens_hsa008300.82126353
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.81675087
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78397536
50Linoleic acid metabolism_Homo sapiens_hsa005910.77308006
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76398772
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74572905
53Ribosome_Homo sapiens_hsa030100.74431733
54mRNA surveillance pathway_Homo sapiens_hsa030150.71787634
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71459637
56Fatty acid degradation_Homo sapiens_hsa000710.71340541
57p53 signaling pathway_Homo sapiens_hsa041150.68666223
58Melanogenesis_Homo sapiens_hsa049160.67967975
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67750112
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65191454
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64652785
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62072814
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60698144
64Phototransduction_Homo sapiens_hsa047440.60024141
65Gap junction_Homo sapiens_hsa045400.59248812
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58892375
67Colorectal cancer_Homo sapiens_hsa052100.57223326
68Protein digestion and absorption_Homo sapiens_hsa049740.56446778
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55827063
70Serotonergic synapse_Homo sapiens_hsa047260.55680958
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53986011
72Circadian entrainment_Homo sapiens_hsa047130.53534616
73RNA polymerase_Homo sapiens_hsa030200.51991891
74Systemic lupus erythematosus_Homo sapiens_hsa053220.51742271
75Pathways in cancer_Homo sapiens_hsa052000.51608738
76Butanoate metabolism_Homo sapiens_hsa006500.51315319
77ECM-receptor interaction_Homo sapiens_hsa045120.47553790
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46636637
79Gastric acid secretion_Homo sapiens_hsa049710.45317354
80One carbon pool by folate_Homo sapiens_hsa006700.45259019
81N-Glycan biosynthesis_Homo sapiens_hsa005100.41569000
82Thyroid hormone synthesis_Homo sapiens_hsa049180.37830346
83Peroxisome_Homo sapiens_hsa041460.37713328
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.35847721
85Folate biosynthesis_Homo sapiens_hsa007900.35643514
86Calcium signaling pathway_Homo sapiens_hsa040200.35038969
87Oocyte meiosis_Homo sapiens_hsa041140.34761245
88ABC transporters_Homo sapiens_hsa020100.34408032
89cAMP signaling pathway_Homo sapiens_hsa040240.32854412
90Collecting duct acid secretion_Homo sapiens_hsa049660.31772905
91Salivary secretion_Homo sapiens_hsa049700.31454651
92Morphine addiction_Homo sapiens_hsa050320.31310398
93MicroRNAs in cancer_Homo sapiens_hsa052060.31101739
94Histidine metabolism_Homo sapiens_hsa003400.30709779
95Fatty acid biosynthesis_Homo sapiens_hsa000610.30526118
96Renin secretion_Homo sapiens_hsa049240.28325609
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27379766
98Bile secretion_Homo sapiens_hsa049760.26963244
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26715962
100Circadian rhythm_Homo sapiens_hsa047100.26688624

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