PSKH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell size (GO:0045792)6.43093216
2plasma membrane repair (GO:0001778)5.28184338
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.08108170
4L-phenylalanine metabolic process (GO:0006558)5.08108170
5L-phenylalanine catabolic process (GO:0006559)5.03894819
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03894819
7negative regulation of protein localization to cell surface (GO:2000009)4.96441329
8positive regulation of myotube differentiation (GO:0010831)4.85307293
9alpha-linolenic acid metabolic process (GO:0036109)4.82667741
10negative regulation of nitric-oxide synthase activity (GO:0051001)4.49054379
11negative regulation of muscle hypertrophy (GO:0014741)4.39718576
12lysine metabolic process (GO:0006553)4.36049287
13lysine catabolic process (GO:0006554)4.36049287
14membrane raft organization (GO:0031579)4.33738180
15negative regulation of cardiac muscle tissue growth (GO:0055022)4.27508782
16negative regulation of heart growth (GO:0061117)4.27508782
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.18113880
18activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.17669986
19sulfur amino acid catabolic process (GO:0000098)4.13865561
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12781534
21glyoxylate metabolic process (GO:0046487)4.11850575
22valine metabolic process (GO:0006573)4.11303698
23regulation of sarcomere organization (GO:0060297)4.01504711
24positive regulation of extracellular matrix organization (GO:1903055)4.00539332
25aromatic amino acid family catabolic process (GO:0009074)3.97677837
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.95435946
27negative regulation of cardiac muscle hypertrophy (GO:0010614)3.89619340
28peptidyl-glutamic acid carboxylation (GO:0017187)3.87826656
29protein carboxylation (GO:0018214)3.87826656
30ethanol oxidation (GO:0006069)3.83440905
31negative regulation of potassium ion transmembrane transport (GO:1901380)3.80136842
32negative regulation of fibrinolysis (GO:0051918)3.76644629
33cysteine metabolic process (GO:0006534)3.72998700
34regulation of skeletal muscle contraction (GO:0014819)3.71204394
35regulation of p38MAPK cascade (GO:1900744)3.70686912
36amino-acid betaine metabolic process (GO:0006577)3.70651426
37heart trabecula formation (GO:0060347)3.59617080
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.59429986
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58943476
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54324086
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54324086
42Golgi transport vesicle coating (GO:0048200)3.51571307
43COPI coating of Golgi vesicle (GO:0048205)3.51571307
44bile acid biosynthetic process (GO:0006699)3.51201560
452-oxoglutarate metabolic process (GO:0006103)3.51067420
46regulation of cholesterol homeostasis (GO:2000188)3.49069772
47kynurenine metabolic process (GO:0070189)3.46236333
48negative regulation of organelle assembly (GO:1902116)3.44836079
49glycine metabolic process (GO:0006544)3.40430923
50urea cycle (GO:0000050)3.38658517
51urea metabolic process (GO:0019627)3.38658517
52regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.38070464
53regulation of protein activation cascade (GO:2000257)3.34302958
54regulation of fibrinolysis (GO:0051917)3.30648730
55modulation by virus of host morphology or physiology (GO:0019048)3.24238620
56tricarboxylic acid metabolic process (GO:0072350)3.23389620
57fatty acid oxidation (GO:0019395)3.19913008
58complement activation, alternative pathway (GO:0006957)3.19382850
59regulation of complement activation (GO:0030449)3.17546928
60serine family amino acid catabolic process (GO:0009071)3.16580840
61basement membrane organization (GO:0071711)3.15926636
62negative regulation of striated muscle cell differentiation (GO:0051154)3.13550241
63tryptophan metabolic process (GO:0006568)3.12752328
64stress fiber assembly (GO:0043149)3.11567973
65lipid oxidation (GO:0034440)3.09760821
664-hydroxyproline metabolic process (GO:0019471)3.09454185
67tryptophan catabolic process (GO:0006569)3.07710333
68indole-containing compound catabolic process (GO:0042436)3.07710333
69indolalkylamine catabolic process (GO:0046218)3.07710333
70adherens junction assembly (GO:0034333)3.06348801
71regulation of extracellular matrix organization (GO:1903053)3.06290888
72glucose catabolic process (GO:0006007)3.06212815
73aspartate family amino acid catabolic process (GO:0009068)3.05638611
74positive regulation of triglyceride biosynthetic process (GO:0010867)3.05593518
75nitrogen cycle metabolic process (GO:0071941)3.05034417
76antigen processing and presentation via MHC class Ib (GO:0002475)3.04832539
77cardiac myofibril assembly (GO:0055003)3.04510620
78folic acid-containing compound biosynthetic process (GO:0009396)3.04327492
79homocysteine metabolic process (GO:0050667)3.03920801
80high-density lipoprotein particle remodeling (GO:0034375)3.02774176
81fatty acid beta-oxidation (GO:0006635)3.01520010
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.98981508
83regulation of extracellular matrix disassembly (GO:0010715)2.98054992
84pinocytosis (GO:0006907)2.97307208
85barbed-end actin filament capping (GO:0051016)2.96070657
86cell-substrate adherens junction assembly (GO:0007045)2.95576457
87focal adhesion assembly (GO:0048041)2.95576457
88regulation of fatty acid beta-oxidation (GO:0031998)2.92603625
89serine family amino acid metabolic process (GO:0009069)2.91394652
90ribosomal small subunit assembly (GO:0000028)2.91373929
91oxaloacetate metabolic process (GO:0006107)2.90921852
92positive regulation of triglyceride metabolic process (GO:0090208)2.90781960
93retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89645931
94bile acid metabolic process (GO:0008206)2.89494916
95negative regulation of cholesterol transport (GO:0032375)2.89401840
96negative regulation of sterol transport (GO:0032372)2.89401840
97syncytium formation by plasma membrane fusion (GO:0000768)2.89315618
98muscle cell cellular homeostasis (GO:0046716)2.87924131
99proline biosynthetic process (GO:0006561)2.87632284
100regulation of triglyceride catabolic process (GO:0010896)2.86444538
101aromatic amino acid family metabolic process (GO:0009072)2.86078965
102COPII vesicle coating (GO:0048208)2.85747961
103cellular ketone body metabolic process (GO:0046950)2.85707748
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85195339
105alpha-amino acid catabolic process (GO:1901606)2.85011703
106tyrosine metabolic process (GO:0006570)2.83528193
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82353490
108negative regulation of fatty acid transport (GO:2000192)2.80822658
109striated muscle atrophy (GO:0014891)2.79992586
110maternal placenta development (GO:0001893)2.79543519
111myoblast fusion (GO:0007520)2.79145323
112carnitine metabolic process (GO:0009437)2.78997920
113antigen processing and presentation of endogenous antigen (GO:0019883)2.77683944
114negative regulation of monooxygenase activity (GO:0032769)2.77305556
115regulation of glucose import in response to insulin stimulus (GO:2001273)2.76908061
116negative regulation of erythrocyte differentiation (GO:0045647)2.76171440
117reverse cholesterol transport (GO:0043691)2.76045225
118protein localization to endosome (GO:0036010)2.75930688
119phospholipid efflux (GO:0033700)2.74687573
120semaphorin-plexin signaling pathway (GO:0071526)2.74182079
121low-density lipoprotein particle clearance (GO:0034383)2.73945093
122modulation by symbiont of host cellular process (GO:0044068)2.73750133
123pentose-phosphate shunt (GO:0006098)2.72739893
124plasma lipoprotein particle clearance (GO:0034381)2.72505498
125triglyceride homeostasis (GO:0070328)2.72085302
126acylglycerol homeostasis (GO:0055090)2.72085302
127protein-lipid complex assembly (GO:0065005)2.71102025
128cellular amino acid catabolic process (GO:0009063)2.69994659
129plasma lipoprotein particle assembly (GO:0034377)2.69502265
130trabecula formation (GO:0060343)2.68466893
131apoptotic process involved in morphogenesis (GO:0060561)2.67837080
132branched-chain amino acid metabolic process (GO:0009081)2.66514796
133response to laminar fluid shear stress (GO:0034616)2.66406497
134fatty acid transmembrane transport (GO:1902001)2.66399820
135regulation of protein localization to cell surface (GO:2000008)2.65715265
136cellular modified amino acid catabolic process (GO:0042219)2.65553926
137negative regulation of cardiac muscle tissue development (GO:0055026)2.64653701
138one-carbon metabolic process (GO:0006730)2.64530567
139epithelial cell-cell adhesion (GO:0090136)2.62693829
140fatty acid catabolic process (GO:0009062)2.61973499
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61584167
142ethanol metabolic process (GO:0006067)2.61264146
143regulation of early endosome to late endosome transport (GO:2000641)2.61225497
144cell-substrate junction assembly (GO:0007044)2.61144610
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60295399
146convergent extension (GO:0060026)2.59323955
147protein retention in ER lumen (GO:0006621)2.58608290
148monocarboxylic acid catabolic process (GO:0072329)2.58168386
149G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.57748009
150skin morphogenesis (GO:0043589)2.56912709
151serine family amino acid biosynthetic process (GO:0009070)2.56440041
152cochlea morphogenesis (GO:0090103)2.56175875
153regulation of gamma-delta T cell differentiation (GO:0045586)2.55413301
154atrioventricular valve morphogenesis (GO:0003181)2.54638694
155modulation by virus of host process (GO:0019054)2.54253812
156acetyl-CoA metabolic process (GO:0006084)2.54073320
157carnitine shuttle (GO:0006853)2.52776094
158positive regulation of fatty acid oxidation (GO:0046321)2.52114367
159cholesterol homeostasis (GO:0042632)2.51856206
160primary alcohol catabolic process (GO:0034310)2.51727653
161Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51698978
162NADPH regeneration (GO:0006740)2.50223872
163pteridine-containing compound biosynthetic process (GO:0042559)2.49546284
164organic acid catabolic process (GO:0016054)2.49487037
165carboxylic acid catabolic process (GO:0046395)2.49487037
166L-alpha-amino acid transmembrane transport (GO:1902475)2.48051713
167embryonic viscerocranium morphogenesis (GO:0048703)2.43753825
168mannose metabolic process (GO:0006013)2.42651054
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41428727
170NADH metabolic process (GO:0006734)2.40141482
171regulation of cholesterol biosynthetic process (GO:0045540)2.37837546
172regulation of establishment of planar polarity (GO:0090175)2.36031740
173regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34979359
174regulation of transforming growth factor beta2 production (GO:0032909)2.34208310
175positive regulation of Cdc42 GTPase activity (GO:0043089)2.34203268
176regulation of ARF protein signal transduction (GO:0032012)2.33449706
177regulation of cardiac muscle cell differentiation (GO:2000725)2.32945251
178cell-cell junction maintenance (GO:0045217)2.31140871
179negative regulation of viral release from host cell (GO:1902187)2.30578921
180positive regulation of adherens junction organization (GO:1903393)2.30311817
181regulation of apoptotic process involved in morphogenesis (GO:1902337)2.27903484
182negative regulation of skeletal muscle tissue development (GO:0048642)2.27224911
183muscle atrophy (GO:0014889)2.27024167
184apoptotic cell clearance (GO:0043277)2.26427455
185membrane assembly (GO:0071709)2.25290376
186intracellular estrogen receptor signaling pathway (GO:0030520)2.25130718
187regulation of NFAT protein import into nucleus (GO:0051532)2.24940079
188glucose 6-phosphate metabolic process (GO:0051156)2.24047372
189activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23347198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.74584733
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.28109186
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.85971269
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81061289
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.11725790
6E2F7_22180533_ChIP-Seq_HELA_Human3.04425641
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63241816
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58018307
9MYC_22102868_ChIP-Seq_BL_Human2.55664243
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48741661
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15495049
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10245985
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.09997942
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99971704
15CLOCK_20551151_ChIP-Seq_293T_Human1.96604063
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91367414
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91367414
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91367414
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.88019723
20SCL_19346495_ChIP-Seq_HPC-7_Human1.86770376
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85995619
22VDR_21846776_ChIP-Seq_THP-1_Human1.82555797
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.78531186
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78216863
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.76491327
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.75530729
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71932718
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.69476355
29TCF7_22412390_ChIP-Seq_EML_Mouse1.67726329
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67529739
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66600560
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65737249
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63120306
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.62434444
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60819883
36KDM2B_26808549_Chip-Seq_K562_Human1.56735689
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54978540
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54128372
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51083745
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50484753
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.49411243
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47268376
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42982742
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41055368
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.38834267
46MAF_26560356_Chip-Seq_TH1_Human1.38518514
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37995397
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37882635
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37537140
50GATA1_22025678_ChIP-Seq_K562_Human1.36443953
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35307897
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34228540
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33469986
54LXR_22292898_ChIP-Seq_THP-1_Human1.31662910
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30824199
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30371763
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29916282
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29206692
59SMC4_20622854_ChIP-Seq_HELA_Human1.29120377
60UTX_26944678_Chip-Seq_JUKART_Human1.28891690
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.26885164
62* P68_20966046_ChIP-Seq_HELA_Human1.25778757
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25433281
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24945025
65CREB1_26743006_Chip-Seq_LNCaP_Human1.24715554
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23619059
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23163471
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22019497
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.21863463
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21318719
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20679679
72ZNF263_19887448_ChIP-Seq_K562_Human1.20536193
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.20477542
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19859922
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18909783
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18029385
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.16980652
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16908266
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16670586
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16195894
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15327034
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13392879
83TP53_22127205_ChIP-Seq_IMR90_Human1.12619811
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12499567
85KDM2B_26808549_Chip-Seq_DND41_Human1.12203227
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.11600845
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.11600845
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10942051
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10441573
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10300861
91VDR_24763502_ChIP-Seq_THP-1_Human1.08682549
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08009200
93ATF3_27146783_Chip-Seq_COLON_Human1.07313520
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07184000
95RACK7_27058665_Chip-Seq_MCF-7_Human1.06664870
96AR_21909140_ChIP-Seq_LNCAP_Human1.06434397
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05931933
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05335529
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04263844
100* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03559672
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03083273
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03046270
103NCOR1_26117541_ChIP-Seq_K562_Human1.02628708
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02381011
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02218203
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02114875
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01279099
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01206020
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00870266
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00727038
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.00411406
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00180748
113SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99861815
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.99803720
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.98395206
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98365902
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97684182
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.96838711
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96801580
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95978349
121MYB_26560356_Chip-Seq_TH1_Human0.95834289
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95487382
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94409491
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94321613
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94008103
126ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92703712
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92413119
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92049531
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91778497
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91476424
131MAF_26560356_Chip-Seq_TH2_Human0.91385128
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91074948
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90675547
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90297514
135MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89795769
136GATA1_19941826_ChIP-Seq_K562_Human0.89362711
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89285291
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88677363
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88384829
140* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87678678
141CHD1_26751641_Chip-Seq_LNCaP_Human0.87256237
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86505237
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85994255
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85719200
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85315699
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84568301
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.84199563
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83973718
149CIITA_25753668_ChIP-Seq_RAJI_Human0.83140167
150XRN2_22483619_ChIP-Seq_HELA_Human0.82266569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75637538
2MP0005360_urolithiasis3.86237849
3MP0005365_abnormal_bile_salt3.66015906
4MP0003950_abnormal_plasma_membrane3.65124524
5MP0005085_abnormal_gallbladder_physiolo3.28569554
6MP0000751_myopathy3.22170701
7MP0004272_abnormal_basement_membrane2.91644404
8MP0008875_abnormal_xenobiotic_pharmacok2.66776152
9MP0005377_hearing/vestibular/ear_phenot2.57741852
10MP0003878_abnormal_ear_physiology2.57741852
11MP0003806_abnormal_nucleotide_metabolis2.45266973
12MP0010329_abnormal_lipoprotein_level2.36320215
13MP0009840_abnormal_foam_cell2.34325065
14MP0010030_abnormal_orbit_morphology2.32093358
15MP0003252_abnormal_bile_duct2.28048774
16MP0004858_abnormal_nervous_system2.27864438
17MP0003705_abnormal_hypodermis_morpholog2.22360099
18MP0005451_abnormal_body_composition2.19937467
19MP0001958_emphysema2.16639329
20MP0000749_muscle_degeneration2.12010335
21MP0006054_spinal_hemorrhage2.03423927
22MP0010368_abnormal_lymphatic_system1.99801235
23MP0003191_abnormal_cellular_cholesterol1.97464841
24MP0003453_abnormal_keratinocyte_physiol1.80617638
25MP0008438_abnormal_cutaneous_collagen1.75763455
26MP0005076_abnormal_cell_differentiation1.75650383
27MP0001666_abnormal_nutrient_absorption1.74062382
28MP0003091_abnormal_cell_migration1.72657174
29MP0005257_abnormal_intraocular_pressure1.70725296
30MP0002877_abnormal_melanocyte_morpholog1.70311224
31MP0008260_abnormal_autophagy1.67661567
32MP0000609_abnormal_liver_physiology1.66642802
33MP0002249_abnormal_larynx_morphology1.63361095
34MP0005409_darkened_coat_color1.58017699
35MP0005083_abnormal_biliary_tract1.55693207
36MP0003279_aneurysm1.54223524
37MP0000750_abnormal_muscle_regeneration1.52669110
38MP0000678_abnormal_parathyroid_gland1.50449956
39MP0010352_gastrointestinal_tract_polyps1.49786521
40MP0000858_altered_metastatic_potential1.48304320
41MP0005332_abnormal_amino_acid1.45972657
42MP0005623_abnormal_meninges_morphology1.44901512
43MP0009643_abnormal_urine_homeostasis1.43639107
44MP0003828_pulmonary_edema1.42832282
45MP0003195_calcinosis1.42776035
46MP0003303_peritoneal_inflammation1.36716633
47MP0003300_gastrointestinal_ulcer1.35708110
48MP0005319_abnormal_enzyme/_coenzyme1.30105472
49MP0005220_abnormal_exocrine_pancreas1.29690744
50MP0000467_abnormal_esophagus_morphology1.27097664
51MP0005330_cardiomyopathy1.26932277
52MP0002118_abnormal_lipid_homeostasis1.26512317
53MP0009384_cardiac_valve_regurgitation1.24895970
54MP0000759_abnormal_skeletal_muscle1.24529402
55MP0002896_abnormal_bone_mineralization1.23407445
56MP0005670_abnormal_white_adipose1.21877763
57MP0000598_abnormal_liver_morphology1.21328239
58MP0001756_abnormal_urination1.20053463
59MP0003172_abnormal_lysosome_physiology1.18395983
60MP0003566_abnormal_cell_adhesion1.17040584
61MP0004233_abnormal_muscle_weight1.16172079
62MP0004087_abnormal_muscle_fiber1.13828017
63MP0003693_abnormal_embryo_hatching1.13681073
64MP0005503_abnormal_tendon_morphology1.11943068
65MP0003868_abnormal_feces_composition1.10192389
66MP0005023_abnormal_wound_healing1.07425572
67MP0003115_abnormal_respiratory_system1.06360698
68MP0002138_abnormal_hepatobiliary_system1.04457650
69MP0002396_abnormal_hematopoietic_system1.01276077
70MP0002254_reproductive_system_inflammat1.00756997
71MP0003186_abnormal_redox_activity0.96973388
72MP0005501_abnormal_skin_physiology0.96883616
73MP0002796_impaired_skin_barrier0.95978174
74MP0000537_abnormal_urethra_morphology0.95682746
75MP0004808_abnormal_hematopoietic_stem0.93927452
76MP0000685_abnormal_immune_system0.92819826
77MP0001542_abnormal_bone_strength0.92507857
78MP0000465_gastrointestinal_hemorrhage0.92260534
79MP0002998_abnormal_bone_remodeling0.91980888
80MP0005508_abnormal_skeleton_morphology0.90629694
81MP0002108_abnormal_muscle_morphology0.89932342
82MP0005584_abnormal_enzyme/coenzyme_acti0.89838214
83MP0000747_muscle_weakness0.89571303
84MP0001545_abnormal_hematopoietic_system0.89396785
85MP0005397_hematopoietic_system_phenotyp0.89396785
86MP0005408_hypopigmentation0.89072702
87MP0005464_abnormal_platelet_physiology0.88773575
88MP0010234_abnormal_vibrissa_follicle0.87714695
89MP0000767_abnormal_smooth_muscle0.87111008
90MP0004883_abnormal_blood_vessel0.86941405
91MP0001915_intracranial_hemorrhage0.85993427
92MP0009278_abnormal_bone_marrow0.85919846
93MP0001849_ear_inflammation0.85139602
94MP0009053_abnormal_anal_canal0.85015116
95MP0001533_abnormal_skeleton_physiology0.84720088
96MP0004130_abnormal_muscle_cell0.83286083
97MP0009697_abnormal_copulation0.82748835
98MP0006138_congestive_heart_failure0.82357819
99MP0000003_abnormal_adipose_tissue0.82274169
100MP0004019_abnormal_vitamin_homeostasis0.82104395
101MP0004885_abnormal_endolymph0.81037441
102MP0010630_abnormal_cardiac_muscle0.80326458
103MP0005666_abnormal_adipose_tissue0.80287416
104MP0001764_abnormal_homeostasis0.78268466
105MP0005058_abnormal_lysosome_morphology0.77859529
106MP0000462_abnormal_digestive_system0.77208158
107MP0009763_increased_sensitivity_to0.76939496
108MP0005390_skeleton_phenotype0.76041865
109MP0001614_abnormal_blood_vessel0.75558506
110MP0000490_abnormal_crypts_of0.75478695
111MP0009672_abnormal_birth_weight0.75317505
112MP0006036_abnormal_mitochondrial_physio0.74507935
113MP0008961_abnormal_basal_metabolism0.74091454
114MP0002933_joint_inflammation0.74017871
115MP0004264_abnormal_extraembryonic_tissu0.73798666
116MP0000534_abnormal_ureter_morphology0.73677270
117MP0002106_abnormal_muscle_physiology0.72673670
118MP0003385_abnormal_body_wall0.72619567
119MP0003656_abnormal_erythrocyte_physiolo0.72229427
120MP0001873_stomach_inflammation0.72150514
121MP0002092_abnormal_eye_morphology0.72001758
122MP0008469_abnormal_protein_level0.71735356
123MP0005275_abnormal_skin_tensile0.70173425
124MP0002128_abnormal_blood_circulation0.70154923
125MP0002086_abnormal_extraembryonic_tissu0.69648494
126MP0001944_abnormal_pancreas_morphology0.69106472
127MP0002136_abnormal_kidney_physiology0.69060414
128MP0002113_abnormal_skeleton_development0.68986085
129MP0003724_increased_susceptibility_to0.68755413
130MP0001270_distended_abdomen0.68617438
131MP0002088_abnormal_embryonic_growth/wei0.68207956
132MP0002269_muscular_atrophy0.68198658
133MP0009780_abnormal_chondrocyte_physiolo0.68005002
134MP0002166_altered_tumor_susceptibility0.67757135
135MP0002060_abnormal_skin_morphology0.67439306
136MP0002932_abnormal_joint_morphology0.66773188
137MP0003984_embryonic_growth_retardation0.66570819
138MP0003011_delayed_dark_adaptation0.65585654
139MP0005369_muscle_phenotype0.65406591
140MP0004185_abnormal_adipocyte_glucose0.65348375
141MP0003795_abnormal_bone_structure0.65281446
142MP0001697_abnormal_embryo_size0.64725160
143MP0001879_abnormal_lymphatic_vessel0.64595954
144MP0004084_abnormal_cardiac_muscle0.64379401
145MP0010155_abnormal_intestine_physiology0.64154764
146MP0003567_abnormal_fetal_cardiomyocyte0.63883301
147MP0003436_decreased_susceptibility_to0.63496094
148MP0004782_abnormal_surfactant_physiolog0.63399463
149MP0000681_abnormal_thyroid_gland0.63293344
150MP0002089_abnormal_postnatal_growth/wei0.62872179
151MP0000733_abnormal_muscle_development0.62269805
152MP0002970_abnormal_white_adipose0.62230126
153MP0001661_extended_life_span0.61823406
154MP0003329_amyloid_beta_deposits0.61759926
155MP0002078_abnormal_glucose_homeostasis0.61536483
156MP0003942_abnormal_urinary_system0.61405812
157MP0009115_abnormal_fat_cell0.61286861
158MP0002925_abnormal_cardiovascular_devel0.61246596
159MP0001216_abnormal_epidermal_layer0.60794884
160MP0005375_adipose_tissue_phenotype0.60136111
161MP0001730_embryonic_growth_arrest0.59696855
162MP0000249_abnormal_blood_vessel0.59485487
163MP0005334_abnormal_fat_pad0.58983205
164MP0009642_abnormal_blood_homeostasis0.58333252
165MP0002837_dystrophic_cardiac_calcinosis0.57936445
166MP0002135_abnormal_kidney_morphology0.56665699
167MP0002971_abnormal_brown_adipose0.56654921
168MP0004947_skin_inflammation0.56250723

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.11054166
2Exercise-induced myalgia (HP:0003738)4.98741978
3Deep venous thrombosis (HP:0002625)4.85293372
4Hypobetalipoproteinemia (HP:0003563)4.45194631
5Intrahepatic cholestasis (HP:0001406)4.31427789
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.22750859
7Arterial tortuosity (HP:0005116)4.19362312
8Xanthomatosis (HP:0000991)4.05157512
9Vascular tortuosity (HP:0004948)4.02484993
10Distal lower limb muscle weakness (HP:0009053)3.78841682
11Hypoglycemic coma (HP:0001325)3.73575619
12Abnormality of the left ventricular outflow tract (HP:0011103)3.70392760
13Subaortic stenosis (HP:0001682)3.70392760
14Turricephaly (HP:0000262)3.60173959
15Calf muscle hypertrophy (HP:0008981)3.56355383
16Exercise-induced muscle cramps (HP:0003710)3.54427251
17Ketosis (HP:0001946)3.50581768
18Hyperlipoproteinemia (HP:0010980)3.32528482
19Abnormality of the common coagulation pathway (HP:0010990)3.30596627
20Hypolipoproteinemia (HP:0010981)3.16068254
21Abnormality of fatty-acid metabolism (HP:0004359)3.07947648
22Muscle hypertrophy of the lower extremities (HP:0008968)3.07063403
23Ketoacidosis (HP:0001993)3.01682628
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99147933
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.96867214
26Muscle stiffness (HP:0003552)2.94429665
27Complement deficiency (HP:0004431)2.93923248
28Prolonged partial thromboplastin time (HP:0003645)2.92757058
29Hyperammonemia (HP:0001987)2.91608123
30Protrusio acetabuli (HP:0003179)2.91502519
31Aortic dissection (HP:0002647)2.90939009
32Vertebral compression fractures (HP:0002953)2.85797968
33Abnormality of the intrinsic pathway (HP:0010989)2.83813723
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.73365217
35Spontaneous hematomas (HP:0007420)2.72242844
36Joint hemorrhage (HP:0005261)2.71609268
37Generalized aminoaciduria (HP:0002909)2.67808258
38Ulnar bowing (HP:0003031)2.67045239
39Spastic diplegia (HP:0001264)2.66762620
40Hypercholesterolemia (HP:0003124)2.65936293
41Myopathic facies (HP:0002058)2.60977937
42Sudden death (HP:0001699)2.46915434
43Hypoalphalipoproteinemia (HP:0003233)2.46811783
44Esophageal varix (HP:0002040)2.46713210
45Broad metatarsal (HP:0001783)2.46388805
46Late onset (HP:0003584)2.45321542
47Spondylolisthesis (HP:0003302)2.45262378
48Polycythemia (HP:0001901)2.44626104
49Blue sclerae (HP:0000592)2.42638897
50Abnormality of pyrimidine metabolism (HP:0004353)2.42199129
51Distal lower limb amyotrophy (HP:0008944)2.39812296
52Hyperacusis (HP:0010780)2.39147904
53Hyperbilirubinemia (HP:0002904)2.38537688
54Mitral regurgitation (HP:0001653)2.38021920
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37865920
56Hyperglycinuria (HP:0003108)2.36581304
57Increased variability in muscle fiber diameter (HP:0003557)2.36426814
58Fat malabsorption (HP:0002630)2.34211384
59Spinal rigidity (HP:0003306)2.27755238
60Thin bony cortex (HP:0002753)2.27137575
61Thrombocytosis (HP:0001894)2.23757672
62Abnormal platelet volume (HP:0011876)2.23627488
63Impaired platelet aggregation (HP:0003540)2.22323056
64Abnormal platelet function (HP:0011869)2.22323056
65Obstructive sleep apnea (HP:0002870)2.22048758
66Myocardial infarction (HP:0001658)2.22021262
67Gingival bleeding (HP:0000225)2.20628675
68Increased connective tissue (HP:0009025)2.19797600
69Abnormality of nucleobase metabolism (HP:0010932)2.19761799
70Abnormality of the nasal mucosa (HP:0000433)2.19053822
71Abnormality of the pancreatic islet cells (HP:0006476)2.18839847
72Abnormality of endocrine pancreas physiology (HP:0012093)2.18839847
73Hepatocellular carcinoma (HP:0001402)2.18205639
74Hypoglycemic seizures (HP:0002173)2.17789312
75Aortic regurgitation (HP:0001659)2.15800131
76Dilatation of the ascending aorta (HP:0005111)2.13113021
77Biconcave vertebral bodies (HP:0004586)2.11813992
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11765542
79Hemorrhage of the eye (HP:0011885)2.11722296
80Increased mean platelet volume (HP:0011877)2.11471805
81Abnormality of serine family amino acid metabolism (HP:0010894)2.11005842
82Abnormality of glycine metabolism (HP:0010895)2.11005842
83Epidermoid cyst (HP:0200040)2.10916411
84Myoglobinuria (HP:0002913)2.10541642
85Peritonitis (HP:0002586)2.10298296
86Abnormality of complement system (HP:0005339)2.09607264
87Abnormality of skeletal muscle fiber size (HP:0012084)2.09338076
88Abnormality of purine metabolism (HP:0004352)2.08543134
89Abnormality of transition element cation homeostasis (HP:0011030)2.08232065
90Bladder diverticulum (HP:0000015)2.08196152
91Abnormality of iron homeostasis (HP:0011031)2.07085192
92Neck muscle weakness (HP:0000467)2.06936099
93Type 1 muscle fiber predominance (HP:0003803)2.06578273
94Aneurysm (HP:0002617)2.05479511
95Joint laxity (HP:0001388)2.05407446
96Broad face (HP:0000283)2.04659801
97Acanthocytosis (HP:0001927)2.04235058
98Back pain (HP:0003418)2.03926831
99Ankle contracture (HP:0006466)2.03803155
100Abnormality of methionine metabolism (HP:0010901)2.03644371
101Increased serum ferritin (HP:0003281)2.03578877
102Flat acetabular roof (HP:0003180)2.03360978
103Asymmetry of the thorax (HP:0001555)2.00087879
104Shallow orbits (HP:0000586)1.99179263
105Disproportionate tall stature (HP:0001519)1.98723834
106Mitral valve prolapse (HP:0001634)1.98377808
107Hyperglycinemia (HP:0002154)1.97557693
108Hypoplasia of the thymus (HP:0000778)1.96709027
109Cerebral aneurysm (HP:0004944)1.95898935
110Fragile skin (HP:0001030)1.95880206
111Achilles tendon contracture (HP:0001771)1.94183756
112Abnormality of the calf musculature (HP:0001430)1.93675196
113Myotonia (HP:0002486)1.92910646
114Radial bowing (HP:0002986)1.92666433
115Dicarboxylic aciduria (HP:0003215)1.92185796
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92185796
117Dysostosis multiplex (HP:0000943)1.91041853
118Soft skin (HP:0000977)1.90915664
119Cervical subluxation (HP:0003308)1.90593073
120Delayed CNS myelination (HP:0002188)1.90136296
121Wormian bones (HP:0002645)1.88722594
122Asymmetric septal hypertrophy (HP:0001670)1.88706376
123Epistaxis (HP:0000421)1.88705321
124Thrombophlebitis (HP:0004418)1.87525382
125Abnormal cartilage morphology (HP:0002763)1.87208206
126Short nail (HP:0001799)1.87114676
127Pancreatic islet-cell hyperplasia (HP:0004510)1.86918295
128Abnormality of the acetabulum (HP:0003170)1.86658450
129Bowing of the arm (HP:0006488)1.86563813
130Bowed forearm bones (HP:0003956)1.86563813
131Metatarsus adductus (HP:0001840)1.84795668
132Abnormality of the Achilles tendon (HP:0005109)1.84779169
133Long toe (HP:0010511)1.84539061
134Beaking of vertebral bodies (HP:0004568)1.83485992
135Hyperinsulinemic hypoglycemia (HP:0000825)1.83127378
136Menorrhagia (HP:0000132)1.83058150
137Metabolic acidosis (HP:0001942)1.82671186
138Mitral stenosis (HP:0001718)1.81917670
139Genu recurvatum (HP:0002816)1.81635071
140Distal upper limb amyotrophy (HP:0007149)1.78507782
141Upper limb amyotrophy (HP:0009129)1.78507782
142Purpura (HP:0000979)1.78205743
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.78110506
144Ectopia lentis (HP:0001083)1.77854606
145Gowers sign (HP:0003391)1.75904580
146Aortic aneurysm (HP:0004942)1.75409463
147Skin nodule (HP:0200036)1.75355855
148Urinary glycosaminoglycan excretion (HP:0003541)1.75318135
149Mucopolysacchariduria (HP:0008155)1.75318135
150Steatorrhea (HP:0002570)1.75100019
151Thoracic kyphosis (HP:0002942)1.75018254
152Abnormality of the thoracic spine (HP:0100711)1.74060005
153Abnormality of the 4th metacarpal (HP:0010012)1.74019937
154Atrophic scars (HP:0001075)1.73772620
155Gout (HP:0001997)1.72727967
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.70886437
157Hepatosplenomegaly (HP:0001433)1.70773309
158Axonal loss (HP:0003447)1.70392858
159Hyperextensible skin (HP:0000974)1.70213667
160Increased cerebral lipofuscin (HP:0011813)1.69964987
161Premature rupture of membranes (HP:0001788)1.69943129
162Hyperglycemia (HP:0003074)1.69732004
163Mildly elevated creatine phosphokinase (HP:0008180)1.68665878
164Abnormality of carpal bone ossification (HP:0006257)1.68660657
165Enlarged penis (HP:0000040)1.68619074
166Abnormality of polysaccharide metabolism (HP:0011012)1.67911916
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67911916
168Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67911916
169Cupped ribs (HP:0000887)1.65853754
170Lymphangioma (HP:0100764)1.65517035
171Abnormal ossification of hand bones (HP:0005921)1.65071359
172Spontaneous abortion (HP:0005268)1.64780029
173Joint stiffness (HP:0001387)1.64701776
174Easy fatigability (HP:0003388)1.64675236
175Systemic lupus erythematosus (HP:0002725)1.64376790
176Hyporeflexia of lower limbs (HP:0002600)1.62885605
177Renal duplication (HP:0000075)1.61957436
178Long palpebral fissure (HP:0000637)1.60928002
179Round ear (HP:0100830)1.59865620
180Ulnar deviation of the wrist (HP:0003049)1.59717882
181Abnormality of the distal phalanges of the toes (HP:0010182)1.57629118
182Abnormality of dentin (HP:0010299)1.57521845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.23461773
2SMG13.37791833
3TRIB33.28653876
4BCKDK3.27534526
5PKN23.12464700
6EEF2K3.02864029
7PRPF4B2.67120096
8TGFBR12.59780744
9FLT32.56019338
10MAP4K12.53256916
11FGFR42.45715528
12SIK12.34712483
13TGFBR22.27074725
14MAP3K102.19010469
15MAPKAPK51.93205632
16PTK61.89724952
17CDK81.89303354
18IRAK31.86838089
19EPHA21.83812234
20PDGFRA1.81711216
21TIE11.78871616
22RIPK11.76230819
23TESK11.75660799
24LRRK21.74442591
25JAK31.72668670
26LATS11.66368380
27TAOK31.64940734
28TTN1.61593195
29STK101.50090728
30MAP3K111.49170058
31TESK21.42555798
32TAOK21.42404075
33DYRK31.42380012
34DDR21.35650993
35MUSK1.35214355
36MARK21.32624648
37RPS6KB21.29868215
38PRKD21.29740466
39KDR1.26511172
40ACVR1B1.25628796
41CDK41.24002936
42LMTK21.21973238
43PASK1.21254598
44CDK61.18072523
45EPHB11.17424623
46MAP2K31.17259001
47PAK41.16246256
48HIPK21.14868570
49TYRO31.14644708
50PRKD31.12698466
51ZAP701.12502446
52RPS6KA41.10660251
53ARAF1.10309763
54BTK1.10255418
55PTK21.10008409
56INSRR1.05879629
57MOS1.01943306
58MTOR1.00262496
59SCYL20.99158988
60EPHB20.98728113
61MAP3K80.96866623
62CDC42BPA0.96281118
63TYK20.95390626
64PIM20.95150175
65CAMK1D0.92920415
66ICK0.90774611
67KIT0.85779983
68RPS6KA20.84283430
69MELK0.81687108
70MAPK70.78810415
71TBK10.78529258
72KSR20.77787445
73EPHA30.77707128
74MAP3K60.77213886
75PDPK10.77115109
76STK30.76917931
77MAPKAPK30.75969837
78GRK60.75745706
79NEK20.74705253
80MAP3K30.74046403
81CCNB10.73786331
82CDK120.72985363
83IRAK20.72182967
84JAK20.70724135
85MET0.70158868
86MAPK110.69524040
87BRSK20.69230825
88WEE10.68684866
89RPS6KC10.67697667
90RPS6KL10.67697667
91NME20.66919135
92CAMK1G0.58362914
93LATS20.56758221
94NTRK10.56053805
95FGFR30.55893102
96PRKG20.55181923
97PAK20.54975119
98JAK10.53707430
99FGFR20.53615760
100CDK70.53170579
101MAP3K10.52548430
102TAOK10.52248171
103TNK20.51721982
104MAPK150.51699628
105CDK90.50862872
106DMPK0.50560416
107DYRK1B0.50548880
108PDGFRB0.50469349
109ITK0.48286326
110BMX0.48149756
111CSK0.48127795
112MAP2K20.47542866
113NLK0.47067002
114PIK3CG0.45228474
115IRAK40.44950694
116MAPK120.44287268
117MAPK40.44121865
118CHUK0.42964642
119RPS6KA60.42609485
120MYLK0.42512563
121STK380.41734164
122FGFR10.41706560
123CSNK1G10.40826013
124CDC70.40335111
125AURKB0.40211977
126AKT20.39469526
127CSF1R0.39037468
128ILK0.37201929
129PIM10.36277997
130GSK3A0.35449192
131MAP3K70.35398005
132RET0.34312235
133PAK60.33323690
134ROCK20.33168991
135NEK10.32718013
136CSNK1G30.32676967
137NEK90.32481983
138BLK0.32300400
139MAP3K130.32156686
140CSNK1A1L0.31480367
141MAPKAPK20.29817926
142STK40.29164784
143CLK10.28902837
144MAPK30.28437682

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.38494218
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06400556
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79193694
4Fatty acid degradation_Homo sapiens_hsa000712.77528695
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40750831
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.37780634
7Nitrogen metabolism_Homo sapiens_hsa009102.34364221
8Tryptophan metabolism_Homo sapiens_hsa003802.23606427
9Selenocompound metabolism_Homo sapiens_hsa004502.19037116
10Sulfur relay system_Homo sapiens_hsa041222.14939430
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12400381
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09096509
13Arginine biosynthesis_Homo sapiens_hsa002202.04917898
14Complement and coagulation cascades_Homo sapiens_hsa046102.04682886
15Folate biosynthesis_Homo sapiens_hsa007902.03759863
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03642696
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89156025
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83595637
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80120607
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.76284305
21Fructose and mannose metabolism_Homo sapiens_hsa000511.75261067
22Propanoate metabolism_Homo sapiens_hsa006401.75093102
23Caffeine metabolism_Homo sapiens_hsa002321.71478273
24Fatty acid metabolism_Homo sapiens_hsa012121.70252081
25Peroxisome_Homo sapiens_hsa041461.67954135
26Pancreatic cancer_Homo sapiens_hsa052121.66730362
27Focal adhesion_Homo sapiens_hsa045101.62933804
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.62282681
29PPAR signaling pathway_Homo sapiens_hsa033201.59766734
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59166147
31Lysine degradation_Homo sapiens_hsa003101.52047829
32Butanoate metabolism_Homo sapiens_hsa006501.47913818
33beta-Alanine metabolism_Homo sapiens_hsa004101.40054079
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39104457
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.38248610
36Biosynthesis of amino acids_Homo sapiens_hsa012301.33617708
37Pyruvate metabolism_Homo sapiens_hsa006201.30652306
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30400699
39Carbon metabolism_Homo sapiens_hsa012001.30224263
40ABC transporters_Homo sapiens_hsa020101.30069150
41Colorectal cancer_Homo sapiens_hsa052101.28352066
42VEGF signaling pathway_Homo sapiens_hsa043701.28222953
43Histidine metabolism_Homo sapiens_hsa003401.28063453
44Starch and sucrose metabolism_Homo sapiens_hsa005001.28038000
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.27315375
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26037456
47Amoebiasis_Homo sapiens_hsa051461.25466251
48Non-small cell lung cancer_Homo sapiens_hsa052231.24783957
49Endometrial cancer_Homo sapiens_hsa052131.23383009
50Sulfur metabolism_Homo sapiens_hsa009201.21071848
51Retinol metabolism_Homo sapiens_hsa008301.19695237
52Chemical carcinogenesis_Homo sapiens_hsa052041.19280296
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15744816
54One carbon pool by folate_Homo sapiens_hsa006701.13940813
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13765641
56Renal cell carcinoma_Homo sapiens_hsa052111.12529224
57Staphylococcus aureus infection_Homo sapiens_hsa051501.09678853
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07688461
59Adherens junction_Homo sapiens_hsa045201.07562417
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05180300
61Fat digestion and absorption_Homo sapiens_hsa049751.01257048
62Lysosome_Homo sapiens_hsa041420.99906247
63Insulin resistance_Homo sapiens_hsa049310.99530809
64Phenylalanine metabolism_Homo sapiens_hsa003600.97911932
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97624650
66Prion diseases_Homo sapiens_hsa050200.97344037
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95404714
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.94464275
69Pentose phosphate pathway_Homo sapiens_hsa000300.94460915
70Tyrosine metabolism_Homo sapiens_hsa003500.94372317
71Endocytosis_Homo sapiens_hsa041440.94037216
72Prostate cancer_Homo sapiens_hsa052150.92089916
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88919131
74Bile secretion_Homo sapiens_hsa049760.88861830
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88639648
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87010900
77Hepatitis C_Homo sapiens_hsa051600.86436807
78Hepatitis B_Homo sapiens_hsa051610.86431913
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.85858478
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.85035867
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83709263
82Osteoclast differentiation_Homo sapiens_hsa043800.81893416
83Apoptosis_Homo sapiens_hsa042100.81726701
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81649742
85Dilated cardiomyopathy_Homo sapiens_hsa054140.80122656
86Galactose metabolism_Homo sapiens_hsa000520.79575888
87Arginine and proline metabolism_Homo sapiens_hsa003300.76886856
88mTOR signaling pathway_Homo sapiens_hsa041500.74311264
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73079423
90AMPK signaling pathway_Homo sapiens_hsa041520.72051287
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68099717
92Pertussis_Homo sapiens_hsa051330.67512909
93B cell receptor signaling pathway_Homo sapiens_hsa046620.67166691
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66965652
95TNF signaling pathway_Homo sapiens_hsa046680.66575129
96MicroRNAs in cancer_Homo sapiens_hsa052060.65520585
97Glioma_Homo sapiens_hsa052140.62620158
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60908750
99Protein digestion and absorption_Homo sapiens_hsa049740.60420649
100Protein export_Homo sapiens_hsa030600.60354756
101Vibrio cholerae infection_Homo sapiens_hsa051100.60180435
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59529842
103Viral myocarditis_Homo sapiens_hsa054160.59338690
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.58964831
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58813769
106Glycerolipid metabolism_Homo sapiens_hsa005610.58790272
107Choline metabolism in cancer_Homo sapiens_hsa052310.58735617
108Fatty acid elongation_Homo sapiens_hsa000620.58353704
109Toxoplasmosis_Homo sapiens_hsa051450.58102621
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56563775
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.56552745
112HIF-1 signaling pathway_Homo sapiens_hsa040660.56196169
113Pathways in cancer_Homo sapiens_hsa052000.56044089
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55583813
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55496931
116Basal cell carcinoma_Homo sapiens_hsa052170.55489173
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54113042
118Prolactin signaling pathway_Homo sapiens_hsa049170.54075277
119Malaria_Homo sapiens_hsa051440.53573583
120Steroid biosynthesis_Homo sapiens_hsa001000.52546497
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.52247224
122Glutathione metabolism_Homo sapiens_hsa004800.51630374
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50110520
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47332038
125Notch signaling pathway_Homo sapiens_hsa043300.46401253
126Antigen processing and presentation_Homo sapiens_hsa046120.44062651
127DNA replication_Homo sapiens_hsa030300.43558174
128Vitamin digestion and absorption_Homo sapiens_hsa049770.42248745
129Chronic myeloid leukemia_Homo sapiens_hsa052200.41434207
130Ribosome_Homo sapiens_hsa030100.40635356
131Acute myeloid leukemia_Homo sapiens_hsa052210.38063301
132Glucagon signaling pathway_Homo sapiens_hsa049220.37948341
133N-Glycan biosynthesis_Homo sapiens_hsa005100.35592158
134Other glycan degradation_Homo sapiens_hsa005110.35061499
135Base excision repair_Homo sapiens_hsa034100.33172637
136Small cell lung cancer_Homo sapiens_hsa052220.32806476
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30627526
138Thyroid cancer_Homo sapiens_hsa052160.30604050
139Viral carcinogenesis_Homo sapiens_hsa052030.29977415
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29646813
141p53 signaling pathway_Homo sapiens_hsa041150.28217118
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.27377378
143Insulin signaling pathway_Homo sapiens_hsa049100.26759571
144Cell cycle_Homo sapiens_hsa041100.26633637
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26362392
146Legionellosis_Homo sapiens_hsa051340.26101098
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25805143
148Bladder cancer_Homo sapiens_hsa052190.25072695
149ECM-receptor interaction_Homo sapiens_hsa045120.24295589
150Herpes simplex infection_Homo sapiens_hsa051680.22952932
151Metabolic pathways_Homo sapiens_hsa011000.22474764
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.21573672
153Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20520334
154Proteoglycans in cancer_Homo sapiens_hsa052050.20363818
155Systemic lupus erythematosus_Homo sapiens_hsa053220.20131858
156HTLV-I infection_Homo sapiens_hsa051660.20016899
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19536684

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