PSG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* female pregnancy (GO:0007565)8.73873620
2regulation of gonadotropin secretion (GO:0032276)8.66999823
3response to follicle-stimulating hormone (GO:0032354)8.39046225
4glucocorticoid biosynthetic process (GO:0006704)7.87739555
5keratinization (GO:0031424)7.75753318
6estrogen metabolic process (GO:0008210)7.68114855
7androgen biosynthetic process (GO:0006702)7.15076131
8androgen metabolic process (GO:0008209)6.67215075
9* multi-multicellular organism process (GO:0044706)6.39066189
10prostate gland growth (GO:0060736)6.18346103
11parturition (GO:0007567)5.71535720
12* multi-organism reproductive process (GO:0044703)5.53941614
13sphingoid metabolic process (GO:0046519)5.01789820
14glucocorticoid metabolic process (GO:0008211)4.97490033
15hormone biosynthetic process (GO:0042446)4.75404140
16response to gonadotropin (GO:0034698)4.74643526
17regulation of transforming growth factor beta1 production (GO:0032908)4.35180921
18positive regulation of cellular amide metabolic process (GO:0034250)4.33446555
19endocrine hormone secretion (GO:0060986)4.29483213
20establishment of skin barrier (GO:0061436)4.27998924
21positive regulation of growth hormone secretion (GO:0060124)4.24544727
22myoblast fusion (GO:0007520)4.10006958
23positive regulation of p38MAPK cascade (GO:1900745)4.05647550
24positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.93626317
25syncytium formation (GO:0006949)3.87120413
26vascular endothelial growth factor signaling pathway (GO:0038084)3.84814637
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.84403131
28sphingosine metabolic process (GO:0006670)3.78876630
29positive regulation of interleukin-8 secretion (GO:2000484)3.73527554
30regulation of water loss via skin (GO:0033561)3.73081626
31skin morphogenesis (GO:0043589)3.70681716
32sequestering of extracellular ligand from receptor (GO:0035581)3.69129667
33lymphangiogenesis (GO:0001946)3.62850408
34syncytium formation by plasma membrane fusion (GO:0000768)3.57507718
35regulation of interleukin-8 secretion (GO:2000482)3.51874443
36progesterone metabolic process (GO:0042448)3.49354599
37C21-steroid hormone biosynthetic process (GO:0006700)3.38883039
38vitamin transmembrane transport (GO:0035461)3.36173546
39positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.35215013
40regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.35215013
41positive regulation of protein kinase C signaling (GO:0090037)3.32089101
42diol metabolic process (GO:0034311)3.30860331
43endocardial cushion development (GO:0003197)3.26781182
44import into cell (GO:0098657)3.25259514
45positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.24561874
46iron ion import (GO:0097286)3.22646827
47mesenchymal-epithelial cell signaling (GO:0060638)3.18386454
48regulation of growth hormone secretion (GO:0060123)3.17771512
49sprouting angiogenesis (GO:0002040)3.17181982
50vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.11651332
51collagen fibril organization (GO:0030199)3.09234445
52negative regulation of activin receptor signaling pathway (GO:0032926)3.03695722
53desmosome organization (GO:0002934)3.03318621
54smooth muscle tissue development (GO:0048745)2.99519516
55type B pancreatic cell proliferation (GO:0044342)2.98691286
56eyelid development in camera-type eye (GO:0061029)2.97550885
57collecting duct development (GO:0072044)2.89406463
58ovulation cycle (GO:0042698)2.88792067
59glomerular basement membrane development (GO:0032836)2.86892224
60regulation of p38MAPK cascade (GO:1900744)2.85914530
61positive regulation of glomerulus development (GO:0090193)2.84085613
62endodermal cell differentiation (GO:0035987)2.83211271
63lymph vessel development (GO:0001945)2.82555516
64surfactant homeostasis (GO:0043129)2.81412872
65cellular response to vitamin (GO:0071295)2.80191078
66keratinocyte development (GO:0003334)2.80113297
67hemidesmosome assembly (GO:0031581)2.73834469
68bone trabecula formation (GO:0060346)2.72849597
69keratinocyte differentiation (GO:0030216)2.72364183
70positive regulation of insulin receptor signaling pathway (GO:0046628)2.71990297
71negative regulation of cell-matrix adhesion (GO:0001953)2.71594039
72regulation of steroid hormone biosynthetic process (GO:0090030)2.69730475
73glomerular visceral epithelial cell development (GO:0072015)2.68010038
74Leydig cell differentiation (GO:0033327)2.67823097
75cell adhesion mediated by integrin (GO:0033627)2.60997024
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.60469840
77hyaluronan catabolic process (GO:0030214)2.59152051
78mesodermal cell differentiation (GO:0048333)2.57170654
79regulation of integrin-mediated signaling pathway (GO:2001044)2.55315915
80positive regulation of transforming growth factor beta production (GO:0071636)2.54228479
81negative regulation of myoblast differentiation (GO:0045662)2.53904154
82bone morphogenesis (GO:0060349)2.52247776
83negative regulation of complement activation (GO:0045916)2.50460769
84wound healing, spreading of epidermal cells (GO:0035313)2.49686408
85cellular hormone metabolic process (GO:0034754)2.47275619
86plasma membrane repair (GO:0001778)2.46349037
87cellular response to gonadotropin stimulus (GO:0071371)2.44048417
88cellular response to vitamin D (GO:0071305)2.42821794
89negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.42578365
90polarized epithelial cell differentiation (GO:0030859)2.41582260
91ovulation from ovarian follicle (GO:0001542)2.39801085
92basement membrane organization (GO:0071711)2.36832217
93extracellular negative regulation of signal transduction (GO:1900116)2.35878681
94extracellular regulation of signal transduction (GO:1900115)2.35878681
95regulation of hippo signaling (GO:0035330)2.33390570
96C21-steroid hormone metabolic process (GO:0008207)2.33384560
97pericardium development (GO:0060039)2.32960708
98cell-substrate junction assembly (GO:0007044)2.32703288
99keratinocyte proliferation (GO:0043616)2.31340032
100estrogen biosynthetic process (GO:0006703)16.5970514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human6.47980089
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.41064641
3EGR1_19032775_ChIP-ChIP_M12_Human3.23488277
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.92888469
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.84665380
6TP53_18474530_ChIP-ChIP_U2OS_Human2.82374094
7* BRD4_25478319_ChIP-Seq_HGPS_Human2.55352208
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47167900
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46184480
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46063550
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33983876
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.32795764
13CJUN_26792858_Chip-Seq_BT549_Human2.29438137
14* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20087871
15AHR_22903824_ChIP-Seq_MCF-7_Human2.15146790
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.08431317
17TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.04212770
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04045034
19* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.99664467
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.99019528
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.97506015
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95399358
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95336720
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95336720
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.90789774
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.90789774
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90471854
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85802951
29TP53_16413492_ChIP-PET_HCT116_Human1.85228102
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84311949
31JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84260872
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.80374376
33TP63_23658742_ChIP-Seq_EP156T_Human1.78209299
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.76790262
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.67993571
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.60345264
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50876251
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.50062041
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49680895
40TAF15_26573619_Chip-Seq_HEK293_Human1.48401872
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44897867
42GBX2_23144817_ChIP-Seq_PC3_Human1.42449288
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.41627363
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40218234
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38540629
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38531128
47* RXR_22108803_ChIP-Seq_LS180_Human1.36288210
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35711011
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33819945
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.32158306
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.26048088
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22322024
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20420575
54SOX2_20726797_ChIP-Seq_SW620_Human1.17970596
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16564395
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16086023
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15623215
58PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14726528
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13982005
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12104957
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10741225
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09112931
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08873196
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.06687183
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06388348
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05997748
67SMAD4_21799915_ChIP-Seq_A2780_Human1.05215381
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04805733
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04492488
70P300_19829295_ChIP-Seq_ESCs_Human1.03797253
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03253357
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99907942
73GATA3_24758297_ChIP-Seq_MCF-7_Human0.99085752
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97644791
75* CDX2_22108803_ChIP-Seq_LS180_Human0.95863776
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94815943
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92848305
78CBP_20019798_ChIP-Seq_JUKART_Human0.92848305
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91072739
80EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90993740
81RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90993740
82UBF1/2_26484160_Chip-Seq_HMECs_Human0.90311478
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87742279
84GATA4_25053715_ChIP-Seq_YYC3_Human0.87651584
85JUN_21703547_ChIP-Seq_K562_Human0.87479093
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85101040
87LXR_22158963_ChIP-Seq_LIVER_Mouse0.83774737
88TCF4_23295773_ChIP-Seq_U87_Human0.81985048
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81967938
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81556891
91VDR_24787735_ChIP-Seq_THP-1_Human0.81246625
92* AR_25329375_ChIP-Seq_VCAP_Human0.79470974
93* SMAD3_21741376_ChIP-Seq_EPCs_Human0.79445036
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79324845
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78664478
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77588090
97EED_16625203_ChIP-ChIP_MESCs_Mouse0.77430312
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77151604
99ER_23166858_ChIP-Seq_MCF-7_Human0.76844094
100TBL1_22424771_ChIP-Seq_293T_Human0.76520646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation6.65146308
2MP0003941_abnormal_skin_development5.16081471
3MP0003950_abnormal_plasma_membrane4.55838309
4MP0008438_abnormal_cutaneous_collagen4.15447862
5MP0005275_abnormal_skin_tensile3.94362836
6MP0010368_abnormal_lymphatic_system2.97463766
7MP0002163_abnormal_gland_morphology2.95444050
8MP0004272_abnormal_basement_membrane2.86718863
9MP0005503_abnormal_tendon_morphology2.79430670
10MP0002796_impaired_skin_barrier2.70818626
11MP0000013_abnormal_adipose_tissue2.48603308
12MP0006276_abnormal_autonomic_nervous2.45092768
13MP0003705_abnormal_hypodermis_morpholog2.41861624
14MP0005257_abnormal_intraocular_pressure2.41662588
15MP0003191_abnormal_cellular_cholesterol2.36296119
16MP0006054_spinal_hemorrhage2.28791966
17MP0009384_cardiac_valve_regurgitation2.18208598
18MP0005647_abnormal_sex_gland2.16106261
19MP0005023_abnormal_wound_healing2.14806537
20MP0005379_endocrine/exocrine_gland_phen2.10426635
21MP0001958_emphysema2.04414808
22MP0000003_abnormal_adipose_tissue1.98040610
23MP0002876_abnormal_thyroid_physiology1.94982157
24MP0010234_abnormal_vibrissa_follicle1.89739605
25MP0010386_abnormal_urinary_bladder1.86851095
26MP0002060_abnormal_skin_morphology1.73259375
27MP0001919_abnormal_reproductive_system1.71318353
28MP0003959_abnormal_lean_body1.62729787
29MP0003279_aneurysm1.60206830
30MP0003566_abnormal_cell_adhesion1.57419748
31MP0003183_abnormal_peptide_metabolism1.56524403
32MP0009780_abnormal_chondrocyte_physiolo1.54154029
33MP0010352_gastrointestinal_tract_polyps1.53767595
34MP0001542_abnormal_bone_strength1.51681859
35MP0005187_abnormal_penis_morphology1.47269339
36MP0000579_abnormal_nail_morphology1.46389796
37MP0001440_abnormal_grooming_behavior1.40439912
38MP0002295_abnormal_pulmonary_circulatio1.34657842
39MP0005501_abnormal_skin_physiology1.33151965
40MP0003453_abnormal_keratinocyte_physiol1.31413954
41MP0005646_abnormal_pituitary_gland1.31302614
42MP0000639_abnormal_adrenal_gland1.29387556
43MP0003091_abnormal_cell_migration1.27837637
44MP0010678_abnormal_skin_adnexa1.26771596
45MP0004947_skin_inflammation1.19760372
46MP0006138_congestive_heart_failure1.18112363
47MP0003936_abnormal_reproductive_system1.17807315
48MP0002998_abnormal_bone_remodeling1.15740204
49MP0002971_abnormal_brown_adipose1.15603984
50MP0005389_reproductive_system_phenotype1.13348143
51MP0010771_integument_phenotype1.12320467
52MP0000647_abnormal_sebaceous_gland1.07801623
53MP0001879_abnormal_lymphatic_vessel1.04854566
54MP0004782_abnormal_surfactant_physiolog1.02728385
55MP0004019_abnormal_vitamin_homeostasis1.02340577
56MP0001243_abnormal_dermal_layer1.02301370
57MP0001299_abnormal_eye_distance/1.01753423
58MP0001756_abnormal_urination1.01166770
59MP0009115_abnormal_fat_cell0.92327204
60MP0000383_abnormal_hair_follicle0.89729609
61MP0000767_abnormal_smooth_muscle0.85902455
62MP0000230_abnormal_systemic_arterial0.85866695
63MP0005375_adipose_tissue_phenotype0.85677563
64MP0003828_pulmonary_edema0.83779891
65MP0000534_abnormal_ureter_morphology0.82608924
66MP0002896_abnormal_bone_mineralization0.82534559
67MP0000681_abnormal_thyroid_gland0.82236671
68MP0005360_urolithiasis0.81087536
69MP0001216_abnormal_epidermal_layer0.80277479
70MP0005508_abnormal_skeleton_morphology0.78682028
71MP0002108_abnormal_muscle_morphology0.77442685
72MP0005595_abnormal_vascular_smooth0.75321700
73MP0002128_abnormal_blood_circulation0.73528074
74MP0003252_abnormal_bile_duct0.69692218
75MP0000367_abnormal_coat/_hair0.69027418
76MP0000627_abnormal_mammary_gland0.68770487
77MP0000427_abnormal_hair_cycle0.68149489
78MP0009053_abnormal_anal_canal0.66357063
79MP0000759_abnormal_skeletal_muscle0.64899661
80MP0002098_abnormal_vibrissa_morphology0.64570314
81MP0000762_abnormal_tongue_morphology0.62386611
82MP0003868_abnormal_feces_composition0.60542788
83MP0005164_abnormal_response_to0.60379188
84MP0003045_fibrosis0.57117566
85MP0005334_abnormal_fat_pad0.56473068
86MP0004085_abnormal_heartbeat0.56360103
87MP0004084_abnormal_cardiac_muscle0.56017589
88MP0005197_abnormal_uvea_morphology0.55543895
89MP0004233_abnormal_muscle_weight0.54796127
90MP0010329_abnormal_lipoprotein_level0.54624086
91MP0001348_abnormal_lacrimal_gland0.53244630
92MP0002138_abnormal_hepatobiliary_system0.53233480
93MP0002972_abnormal_cardiac_muscle0.51204505
94MP0003795_abnormal_bone_structure0.50442628
95MP0001666_abnormal_nutrient_absorption0.50248659
96MP0002269_muscular_atrophy0.48984665
97MP0001915_intracranial_hemorrhage0.48740402
98MP0005058_abnormal_lysosome_morphology0.47732482
99MP0005623_abnormal_meninges_morphology0.47551077
100MP0002136_abnormal_kidney_physiology0.46903853

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)5.71611829
2Follicular hyperkeratosis (HP:0007502)5.37183557
3Abnormality of nail color (HP:0100643)4.83182683
4Protrusio acetabuli (HP:0003179)4.75589553
5Aortic aneurysm (HP:0004942)4.50771663
6Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.48967114
7Premature rupture of membranes (HP:0001788)4.44432027
8Capillary hemangiomas (HP:0005306)3.83703723
9Wormian bones (HP:0002645)3.69802902
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.59723586
11Hypergonadotropic hypogonadism (HP:0000815)3.57398211
12Upper limb muscle weakness (HP:0003484)3.56776921
13Abnormality of glycolipid metabolism (HP:0010969)3.48667123
14Abnormality of liposaccharide metabolism (HP:0010968)3.48667123
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.48667123
16Nonimmune hydrops fetalis (HP:0001790)3.46036084
17Aortic dissection (HP:0002647)3.45142760
18Hydroxyprolinuria (HP:0003080)3.28879205
19Abnormality of proline metabolism (HP:0010907)3.28879205
20Ankle contracture (HP:0006466)3.23634151
21Osteolytic defects of the hand bones (HP:0009699)3.14364722
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.14364722
23Spondylolisthesis (HP:0003302)3.12141277
24Vascular tortuosity (HP:0004948)3.07612607
25Atrophic scars (HP:0001075)3.05456815
26Parakeratosis (HP:0001036)3.03318308
27Cervical subluxation (HP:0003308)2.96273453
28Cardiovascular calcification (HP:0011915)2.94126878
29Fragile skin (HP:0001030)2.82135174
30Mitral stenosis (HP:0001718)2.80757428
31Thyroid-stimulating hormone excess (HP:0002925)2.80186676
32Natal tooth (HP:0000695)2.76457461
33Hypohidrosis (HP:0000966)2.66555181
34Palmoplantar hyperkeratosis (HP:0000972)2.64902717
35Vertebral compression fractures (HP:0002953)2.64596483
36Asymmetric septal hypertrophy (HP:0001670)2.61433770
37Absent frontal sinuses (HP:0002688)2.60596130
38Accelerated skeletal maturation (HP:0005616)2.55229828
39Arterial tortuosity (HP:0005116)2.52945378
40Soft skin (HP:0000977)2.51491221
41Broad metatarsal (HP:0001783)2.49966033
42Thick nail (HP:0001805)2.39690150
43Palmar hyperkeratosis (HP:0010765)2.39495000
44Ectropion (HP:0000656)2.39465169
45Flared iliac wings (HP:0002869)2.36338967
46Abnormal auditory evoked potentials (HP:0006958)2.36279239
47Blue sclerae (HP:0000592)2.34945765
48Neonatal short-limb short stature (HP:0008921)2.34626595
49Neonatal hypoglycemia (HP:0001998)2.32748777
50Elbow flexion contracture (HP:0002987)2.28383428
51Tongue fasciculations (HP:0001308)2.28108287
52Muscle fibrillation (HP:0010546)2.24574789
53Spinal cord lesions (HP:0100561)2.24092133
54Syringomyelia (HP:0003396)2.24092133
55Plantar hyperkeratosis (HP:0007556)2.20716833
56Type 1 muscle fiber predominance (HP:0003803)2.20186840
57Ovoid vertebral bodies (HP:0003300)2.19700919
58Bradycardia (HP:0001662)2.18002363
59Knee flexion contracture (HP:0006380)2.17316468
60Vascular calcification (HP:0004934)2.16406391
61Overgrowth (HP:0001548)2.15759706
62Increased IgE level (HP:0003212)2.14694578
63Autoamputation (HP:0001218)2.14458182
64Erythema (HP:0010783)2.14207302
65Abnormal pupillary function (HP:0007686)2.13934261
66Long eyelashes (HP:0000527)2.13727104
67Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.10183714
68Hyporeflexia of lower limbs (HP:0002600)2.09736451
69Corneal dystrophy (HP:0001131)2.08943212
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08878926
71Aortic regurgitation (HP:0001659)2.05402641
72Dilatation of the ascending aorta (HP:0005111)2.04244741
73Hypoplasia of the iris (HP:0007676)2.03450000
74Dysostosis multiplex (HP:0000943)2.03180770
75Enlarged penis (HP:0000040)2.02847378
76Delayed closure of the anterior fontanelle (HP:0001476)2.02559940
77Corneal erosion (HP:0200020)2.00367233
78Bladder diverticulum (HP:0000015)1.99278793
79Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.97733076
80Persistence of primary teeth (HP:0006335)1.96950016
81Areflexia of lower limbs (HP:0002522)1.96788530
82Distal lower limb muscle weakness (HP:0009053)1.95926524
83Abnormality of the frontal sinuses (HP:0002687)1.95764717
84Urinary glycosaminoglycan excretion (HP:0003541)1.94716483
85Mucopolysacchariduria (HP:0008155)1.94716483
86Aortic valve stenosis (HP:0001650)1.94546116
87Sparse lateral eyebrow (HP:0005338)1.92197578
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91532454
89Abnormality of polysaccharide metabolism (HP:0011012)1.91532454
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91532454
91Spinal rigidity (HP:0003306)1.91421289
92Thoracolumbar scoliosis (HP:0002944)1.86065645
93Broad ribs (HP:0000885)1.85015944
94Tetraparesis (HP:0002273)1.82693670
95Abnormality of dentin (HP:0010299)1.82078511
96Erythroderma (HP:0001019)1.80924712
97Shallow orbits (HP:0000586)1.79356609
98Gonadotropin excess (HP:0000837)1.78351018
99Testicular neoplasm (HP:0010788)1.77614174
100Short nail (HP:0001799)1.76399285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.73852222
2PDGFRA4.51925341
3KDR4.32376873
4EPHA24.30522750
5MYLK4.20152749
6NEK93.15590443
7PAK22.93949988
8LATS12.77326723
9MAP3K122.75938255
10FRK2.19770291
11PDGFRB2.13433360
12MET2.07070416
13TRPM72.03788901
14MST1R1.94066993
15ADRBK21.79308571
16DDR21.76813936
17PTK21.70038376
18ADRBK11.61461604
19ERBB41.49345982
20INSRR1.33479953
21DAPK21.32046771
22SCYL21.29646402
23FLT31.24715386
24ICK1.23980542
25TGFBR21.23366243
26STK381.22962108
27PDK21.21829884
28MST41.20536583
29GRK71.19661056
30ABL21.07201940
31PKN11.05169106
32RIPK11.04469971
33MOS1.03197126
34MAPKAPK31.03111008
35NTRK11.02409714
36DAPK30.99165562
37PTK2B0.92465621
38PRKD20.91032044
39TTN0.89974368
40STK30.89366200
41MAP2K10.87027146
42PRKCE0.84178223
43STK38L0.82137869
44STK240.80363028
45PAK40.77871879
46EIF2AK30.76151356
47LATS20.74071354
48MELK0.73568723
49RPS6KA20.72057964
50BLK0.66531139
51MAPK110.61402062
52MTOR0.61168730
53DAPK10.60686068
54INSR0.59536833
55BMPR20.58366808
56BMX0.58314015
57ROCK10.58127394
58TIE10.56768693
59PRKG20.55049595
60MAP3K90.54948614
61MAP3K30.53156523
62MAP3K60.50479931
63EEF2K0.49933516
64SRC0.49882623
65ERN10.49825100
66CDC42BPA0.49617382
67MAP3K70.49539910
68ILK0.48582039
69GRK50.47578112
70PDPK10.47251936
71ACVR1B0.47232267
72PINK10.46776436
73FER0.46344081
74PRKAA20.45895935
75PIM20.43168121
76PIK3CG0.41862429
77STK100.38857977
78EPHB20.38519698
79JAK10.38297564
80AKT20.36234313
81MAP2K30.36104483
82TGFBR10.34308694
83CAMK2G0.33299488
84EGFR0.31002867
85RPS6KA60.30227364
86IRAK30.28762055
87DYRK30.28347267
88ABL10.28276571
89PAK60.27901088
90RPS6KL10.27332135
91RPS6KC10.27332135
92TAOK20.25999651
93WNK10.25733713
94ROCK20.25335797
95PRKCA0.24764026
96ERBB30.24301962
97PRKD10.23953913
98GRK10.23476929
99PIK3CA0.22075729
100KIT0.21103050

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049136.37895397
2Steroid hormone biosynthesis_Homo sapiens_hsa001405.86014970
3ECM-receptor interaction_Homo sapiens_hsa045123.12169689
4Sphingolipid metabolism_Homo sapiens_hsa006002.87508620
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.55200444
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.51267402
7Focal adhesion_Homo sapiens_hsa045102.11444615
8PI3K-Akt signaling pathway_Homo sapiens_hsa041511.87865780
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78723791
10Dorso-ventral axis formation_Homo sapiens_hsa043201.55446873
11Renin-angiotensin system_Homo sapiens_hsa046141.49845753
12ABC transporters_Homo sapiens_hsa020101.46204569
13Prolactin signaling pathway_Homo sapiens_hsa049171.35495326
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32350685
15Complement and coagulation cascades_Homo sapiens_hsa046101.30508641
16Circadian rhythm_Homo sapiens_hsa047101.24239090
17Proteoglycans in cancer_Homo sapiens_hsa052051.21595175
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19733839
19Other glycan degradation_Homo sapiens_hsa005111.19210839
20Lysosome_Homo sapiens_hsa041421.17050190
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16851054
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16032869
23N-Glycan biosynthesis_Homo sapiens_hsa005101.11580201
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09771074
25Amoebiasis_Homo sapiens_hsa051461.06644790
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06424336
27Salivary secretion_Homo sapiens_hsa049701.05565781
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02094149
29Mineral absorption_Homo sapiens_hsa049780.99857953
30Small cell lung cancer_Homo sapiens_hsa052220.99079840
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98183556
32Ras signaling pathway_Homo sapiens_hsa040140.95219911
33p53 signaling pathway_Homo sapiens_hsa041150.94268707
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89414254
35Adherens junction_Homo sapiens_hsa045200.88710539
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88212023
37Bladder cancer_Homo sapiens_hsa052190.88006795
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87860174
39Platelet activation_Homo sapiens_hsa046110.86301297
40Linoleic acid metabolism_Homo sapiens_hsa005910.85655498
41Malaria_Homo sapiens_hsa051440.84950092
42Protein digestion and absorption_Homo sapiens_hsa049740.82802247
43Endocytosis_Homo sapiens_hsa041440.82788731
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82006153
45TGF-beta signaling pathway_Homo sapiens_hsa043500.81076240
46Tight junction_Homo sapiens_hsa045300.80319750
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79478844
48Melanoma_Homo sapiens_hsa052180.79200877
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.78784823
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78354145
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.77880108
52Axon guidance_Homo sapiens_hsa043600.71964589
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.70088325
54Dilated cardiomyopathy_Homo sapiens_hsa054140.68191110
55Hippo signaling pathway_Homo sapiens_hsa043900.67860034
56Rap1 signaling pathway_Homo sapiens_hsa040150.65210572
57Tryptophan metabolism_Homo sapiens_hsa003800.63643631
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.62467184
59Renal cell carcinoma_Homo sapiens_hsa052110.61963869
60MicroRNAs in cancer_Homo sapiens_hsa052060.59833526
61Pathways in cancer_Homo sapiens_hsa052000.59678782
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57108681
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56509655
64Arachidonic acid metabolism_Homo sapiens_hsa005900.54824608
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53661415
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.53596783
67Retinol metabolism_Homo sapiens_hsa008300.53351348
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52686260
69Inositol phosphate metabolism_Homo sapiens_hsa005620.51493928
70Folate biosynthesis_Homo sapiens_hsa007900.50786245
71Calcium signaling pathway_Homo sapiens_hsa040200.50480550
72Toxoplasmosis_Homo sapiens_hsa051450.49823803
73Phagosome_Homo sapiens_hsa041450.48959276
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47946869
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47155771
76GnRH signaling pathway_Homo sapiens_hsa049120.46943338
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45879363
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45399910
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44333796
80Rheumatoid arthritis_Homo sapiens_hsa053230.43701988
81African trypanosomiasis_Homo sapiens_hsa051430.42864430
82Histidine metabolism_Homo sapiens_hsa003400.42632135
83ErbB signaling pathway_Homo sapiens_hsa040120.41759013
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40463754
85MAPK signaling pathway_Homo sapiens_hsa040100.40266953
86FoxO signaling pathway_Homo sapiens_hsa040680.39775817
87Ether lipid metabolism_Homo sapiens_hsa005650.38755258
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38513412
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37641500
90Olfactory transduction_Homo sapiens_hsa047400.35857751
91Estrogen signaling pathway_Homo sapiens_hsa049150.35099682
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31853951
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31745927
94TNF signaling pathway_Homo sapiens_hsa046680.31704760
95Autoimmune thyroid disease_Homo sapiens_hsa053200.30843069
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30672501
97Phototransduction_Homo sapiens_hsa047440.30531967
98Prostate cancer_Homo sapiens_hsa052150.30291337
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29273065
100Thyroid hormone synthesis_Homo sapiens_hsa049180.28933931

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »