PSEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22659496
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22659496
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.84178832
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.84178832
5modulation by symbiont of host immune response (GO:0052553)4.84178832
6positive regulation by symbiont of host defense response (GO:0052509)4.84178832
7modulation by symbiont of host defense response (GO:0052031)4.84178832
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.84178832
9antigen processing and presentation of endogenous antigen (GO:0019883)4.66509116
10detection of molecule of bacterial origin (GO:0032490)4.23128336
11leukocyte aggregation (GO:0070486)4.19837036
12regulation of interferon-beta biosynthetic process (GO:0045357)4.14391638
13neutrophil activation involved in immune response (GO:0002283)4.10470195
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.94691685
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80179598
16regulation of B cell receptor signaling pathway (GO:0050855)3.74572046
17positive regulation of gamma-delta T cell activation (GO:0046645)3.65974740
18respiratory burst (GO:0045730)3.62531475
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61969860
20negative regulation of cell killing (GO:0031342)3.61969860
21cellular response to ethanol (GO:0071361)3.61124728
22detection of external biotic stimulus (GO:0098581)3.59449993
23response to muramyl dipeptide (GO:0032495)3.54372104
24macrophage activation (GO:0042116)3.53974347
25macrophage activation involved in immune response (GO:0002281)3.52608751
26positive regulation of interferon-alpha production (GO:0032727)3.46605366
27response to peptidoglycan (GO:0032494)3.41389386
28immunoglobulin mediated immune response (GO:0016064)3.39281512
29detection of bacterium (GO:0016045)3.31780842
30regulation of interferon-alpha production (GO:0032647)3.31163029
31Golgi transport vesicle coating (GO:0048200)3.25706652
32COPI coating of Golgi vesicle (GO:0048205)3.25706652
33detection of biotic stimulus (GO:0009595)3.20450167
34cellular extravasation (GO:0045123)3.19215679
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17958771
36T-helper 1 type immune response (GO:0042088)3.12625810
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08722126
38response to host (GO:0075136)3.08722126
39response to host defenses (GO:0052200)3.08722126
40response to type I interferon (GO:0034340)3.07404338
41cellular response to type I interferon (GO:0071357)3.06984444
42type I interferon signaling pathway (GO:0060337)3.06984444
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05117921
44glycosphingolipid catabolic process (GO:0046479)3.03751483
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00975298
46response to host immune response (GO:0052572)3.00975298
47positive regulation of cellular amide metabolic process (GO:0034250)2.99775435
48tolerance induction (GO:0002507)2.98983641
49T cell migration (GO:0072678)2.98459279
50membrane protein intracellular domain proteolysis (GO:0031293)2.97258690
51Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94718532
52macrophage differentiation (GO:0030225)2.93941413
53neutrophil activation (GO:0042119)2.92134845
54leukocyte cell-cell adhesion (GO:0007159)2.89292559
55response to fungus (GO:0009620)2.87567274
56positive regulation of leukocyte degranulation (GO:0043302)2.84314041
57interferon-gamma-mediated signaling pathway (GO:0060333)2.79052876
58regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78625533
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.76622990
60glycolipid catabolic process (GO:0019377)2.76484669
61granulocyte activation (GO:0036230)2.75892008
62RNA destabilization (GO:0050779)2.75674027
63regulation of hypersensitivity (GO:0002883)2.74341374
64oligosaccharide catabolic process (GO:0009313)2.73366174
65myeloid cell activation involved in immune response (GO:0002275)2.70980820
66regulation of vitamin D biosynthetic process (GO:0060556)2.70470418
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66049033
68regulation of gamma-delta T cell activation (GO:0046643)2.65217585
69regulation of podosome assembly (GO:0071801)2.64880425
70defense response to fungus (GO:0050832)2.64680474
71regulation of interleukin-8 biosynthetic process (GO:0045414)2.64439034
72regulation of mast cell activation involved in immune response (GO:0033006)2.62939204
73microglial cell activation (GO:0001774)2.62840108
74regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.62257281
75production of molecular mediator involved in inflammatory response (GO:0002532)2.62230372
76* amyloid precursor protein catabolic process (GO:0042987)2.59120753
77protein localization to endosome (GO:0036010)2.59105706
78germinal center formation (GO:0002467)2.58912768
79regulation of vitamin metabolic process (GO:0030656)2.58278401
80cellular response to exogenous dsRNA (GO:0071360)2.57933471
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56905689
82regulation of gamma-delta T cell differentiation (GO:0045586)2.56780082
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.56652030
84positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56491304
85positive regulation of interferon-beta production (GO:0032728)2.55472903
86regulation of T cell tolerance induction (GO:0002664)2.54002225
87regulation of tolerance induction (GO:0002643)2.53257328
88positive regulation of mast cell activation involved in immune response (GO:0033008)2.52577510
89positive regulation of mast cell degranulation (GO:0043306)2.52577510
90positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52423747
91barbed-end actin filament capping (GO:0051016)2.51982731
92negative regulation of interleukin-8 production (GO:0032717)2.51419720
93regulation of T-helper 2 cell differentiation (GO:0045628)2.50653479
94response to protozoan (GO:0001562)2.50063829
95positive regulation of type 2 immune response (GO:0002830)2.50035387
96regulation of antigen processing and presentation (GO:0002577)2.49867301
97hepatocyte apoptotic process (GO:0097284)2.49595665
98myeloid leukocyte mediated immunity (GO:0002444)2.49005382
99regulation of mononuclear cell migration (GO:0071675)2.48520879
100modulation by symbiont of host cellular process (GO:0044068)2.48100427
101lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48098168
102neutrophil chemotaxis (GO:0030593)2.47964337
103interferon-gamma secretion (GO:0072643)2.47655777
104detection of other organism (GO:0098543)2.47490928
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47404822
106regulation of leukocyte degranulation (GO:0043300)2.46531554
107positive regulation of NF-kappaB import into nucleus (GO:0042346)2.46135658
108positive regulation of chemokine biosynthetic process (GO:0045080)2.45918190
109B cell receptor signaling pathway (GO:0050853)2.45733344
110cytokine secretion (GO:0050663)2.45449669
111myeloid leukocyte activation (GO:0002274)2.45421614
112regulation of cytokine secretion involved in immune response (GO:0002739)2.45194693
113multicellular organism reproduction (GO:0032504)2.44790045
114response to laminar fluid shear stress (GO:0034616)2.44537229
115regulation of mast cell activation (GO:0033003)2.44453043
116positive regulation of monocyte chemotaxis (GO:0090026)2.44240002
117NIK/NF-kappaB signaling (GO:0038061)2.43924804
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43511355
119regulation of response to interferon-gamma (GO:0060330)2.42792987
120regulation of macrophage cytokine production (GO:0010935)2.42786410
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42645257
122positive regulation of mast cell activation (GO:0033005)2.42534593
123neutrophil migration (GO:1990266)2.41443430
124positive regulation of macrophage cytokine production (GO:0060907)2.41321200
125cellular defense response (GO:0006968)2.41153013
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.40938988
127regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.40693189
128positive regulation of B cell differentiation (GO:0045579)2.37533667
129regulation of mast cell degranulation (GO:0043304)2.37310482
130positive regulation of lamellipodium assembly (GO:0010592)2.37170719
131neutrophil mediated immunity (GO:0002446)2.36797451
132lymphocyte chemotaxis (GO:0048247)2.36689955
133positive regulation of antigen processing and presentation (GO:0002579)2.36329020
134regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.36274094
135JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35216892
136actin nucleation (GO:0045010)2.35125036
137positive regulation of lamellipodium organization (GO:1902745)2.33314210
138defense response to protozoan (GO:0042832)2.33281465
139negative regulation of interleukin-12 production (GO:0032695)2.32554209
140leukotriene metabolic process (GO:0006691)2.32232042
141peptide catabolic process (GO:0043171)2.32108714
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.31841270
143fusion of sperm to egg plasma membrane (GO:0007342)2.31444517
144signal peptide processing (GO:0006465)2.30583962
145negative regulation of cytokine production involved in immune response (GO:0002719)2.30049495
146hydrogen peroxide biosynthetic process (GO:0050665)2.28381698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.23285027
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.54869345
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60937494
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.52264588
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27741862
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.16325747
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.13057998
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02934670
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.90473578
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79764566
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78788370
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72390866
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71584973
14* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67650718
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.59143901
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45393233
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31628227
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25887397
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18368033
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13247033
21MYB_26560356_Chip-Seq_TH2_Human2.10159585
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01858516
23SCL_19346495_ChIP-Seq_HPC-7_Human1.99124015
24* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96598039
25RUNX_20019798_ChIP-Seq_JUKART_Human1.95960389
26* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92705677
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92641794
28VDR_21846776_ChIP-Seq_THP-1_Human1.89068689
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88430413
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.85173767
31* SPI1_23547873_ChIP-Seq_NB4_Human1.83414131
32MAF_26560356_Chip-Seq_TH1_Human1.82952502
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82056628
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79410812
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.77716679
36MYB_26560356_Chip-Seq_TH1_Human1.75289774
37VDR_24763502_ChIP-Seq_THP-1_Human1.70307561
38UTX_26944678_Chip-Seq_JUKART_Human1.68636658
39* SPI1_23127762_ChIP-Seq_K562_Human1.65855010
40MYC_22102868_ChIP-Seq_BL_Human1.60492382
41GATA1_22025678_ChIP-Seq_K562_Human1.59540004
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53158570
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52940514
44TCF7_22412390_ChIP-Seq_EML_Mouse1.47350235
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46848069
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.45836893
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45589783
48GATA3_27048872_Chip-Seq_THYMUS_Human1.44283062
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44031264
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42385012
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40279506
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39703903
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37964576
54PU_27001747_Chip-Seq_BMDM_Mouse1.36197804
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29552639
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.28857339
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.26012742
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.25761197
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25641530
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.25418497
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.24348726
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23390334
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22709775
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22645918
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22479504
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21303064
67CLOCK_20551151_ChIP-Seq_293T_Human1.21070371
68VDR_24787735_ChIP-Seq_THP-1_Human1.20087423
69GATA4_25053715_ChIP-Seq_YYC3_Human1.18533326
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17470192
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17318559
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16439511
73GATA3_26560356_Chip-Seq_TH2_Human1.16355342
74* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16315006
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13349548
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.13329986
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12993111
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.12794192
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11766267
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11557384
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10885945
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10312651
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09284542
84* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09096906
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08106747
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.07352318
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06946119
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06812117
89AHR_22903824_ChIP-Seq_MCF-7_Human1.05789304
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04078907
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03605920
92GATA2_19941826_ChIP-Seq_K562_Human1.03500787
93* KDM2B_26808549_Chip-Seq_DND41_Human1.03229344
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03014152
95SOX2_20726797_ChIP-Seq_SW620_Human1.02413771
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01981847
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01342492
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01342492
99* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00869176
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00780830
101LXR_22292898_ChIP-Seq_THP-1_Human1.00660741
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00631045
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99693552
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99656107
105TP53_16413492_ChIP-PET_HCT116_Human0.99115516
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99063251
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97144484
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97139900
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97017455
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96923584
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95507058
112GATA6_25053715_ChIP-Seq_YYC3_Human0.95447851
113TP63_23658742_ChIP-Seq_EP156T_Human0.94987685
114GATA1_19941826_ChIP-Seq_K562_Human0.94770774
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94173584
116* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93760386
117* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93760386
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93011753
119MAF_26560356_Chip-Seq_TH2_Human0.92835996
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92775592
121BCOR_27268052_Chip-Seq_Bcells_Human0.92481420
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92392911
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91510017
124ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91446925
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.89611892
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87542014
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86949452
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85664837
129CJUN_26792858_Chip-Seq_BT549_Human0.85580217
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84392268
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84264835
132* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83639218
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.83306432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.18549172
2MP0001835_abnormal_antigen_presentation3.17402929
3MP0000685_abnormal_immune_system2.77556540
4MP0009785_altered_susceptibility_to2.69010238
5MP0003300_gastrointestinal_ulcer2.66769109
6MP0003303_peritoneal_inflammation2.66713795
7MP0005058_abnormal_lysosome_morphology2.63757772
8MP0002419_abnormal_innate_immunity2.60708764
9MP0006082_CNS_inflammation2.45747927
10MP0005025_abnormal_response_to2.45530376
11* MP0005000_abnormal_immune_tolerance2.36076235
12MP0001790_abnormal_immune_system2.29582375
13MP0005387_immune_system_phenotype2.29582375
14MP0002148_abnormal_hypersensitivity_rea2.26801143
15MP0005671_abnormal_response_to2.24340400
16MP0009840_abnormal_foam_cell2.20124187
17MP0001533_abnormal_skeleton_physiology2.19711988
18* MP0004947_skin_inflammation2.16562982
19MP0008260_abnormal_autophagy2.15305687
20* MP0002452_abnormal_antigen_presenting2.13923431
21MP0003724_increased_susceptibility_to2.13466553
22MP0000569_abnormal_digit_pigmentation2.10238912
23MP0005464_abnormal_platelet_physiology2.03445050
24* MP0002723_abnormal_immune_serum2.03308917
25* MP0001800_abnormal_humoral_immune2.02647571
26* MP0001819_abnormal_immune_cell1.92477218
27* MP0002420_abnormal_adaptive_immunity1.91858010
28MP0003183_abnormal_peptide_metabolism1.90448531
29MP0010155_abnormal_intestine_physiology1.84719029
30MP0003566_abnormal_cell_adhesion1.77558085
31MP0000858_altered_metastatic_potential1.75274463
32MP0002405_respiratory_system_inflammati1.74789259
33* MP0001845_abnormal_inflammatory_respons1.70015086
34MP0002933_joint_inflammation1.68013989
35MP0000465_gastrointestinal_hemorrhage1.64657145
36MP0009333_abnormal_splenocyte_physiolog1.64226841
37MP0002006_tumorigenesis1.63937139
38MP0005410_abnormal_fertilization1.61587119
39MP0008438_abnormal_cutaneous_collagen1.61265903
40MP0000920_abnormal_myelination1.58937546
41MP0003172_abnormal_lysosome_physiology1.58667478
42MP0008004_abnormal_stomach_pH1.57057010
43MP0002998_abnormal_bone_remodeling1.55850427
44* MP0000604_amyloidosis1.55430560
45MP0010234_abnormal_vibrissa_follicle1.54922150
46MP0005023_abnormal_wound_healing1.54508263
47MP0002139_abnormal_hepatobiliary_system1.54438564
48MP0001873_stomach_inflammation1.52766083
49MP0000343_altered_response_to1.52662524
50MP0005310_abnormal_salivary_gland1.48452756
51MP0002166_altered_tumor_susceptibility1.47464684
52MP0002138_abnormal_hepatobiliary_system1.46777896
53MP0003656_abnormal_erythrocyte_physiolo1.46260477
54MP0003448_altered_tumor_morphology1.44372499
55MP0002398_abnormal_bone_marrow1.43626832
56MP0008469_abnormal_protein_level1.41261267
57* MP0000716_abnormal_immune_system1.41042715
58MP0003075_altered_response_to1.39588812
59MP0003091_abnormal_cell_migration1.39544287
60MP0003828_pulmonary_edema1.39108118
61MP0003705_abnormal_hypodermis_morpholog1.36590500
62* MP0001851_eye_inflammation1.36442398
63MP0003763_abnormal_thymus_physiology1.34176574
64MP0009384_cardiac_valve_regurgitation1.33058056
65MP0005451_abnormal_body_composition1.30988511
66MP0005390_skeleton_phenotype1.26149346
67MP0002254_reproductive_system_inflammat1.26135471
68MP0001958_emphysema1.25053834
69MP0002060_abnormal_skin_morphology1.22371280
70MP0003191_abnormal_cellular_cholesterol1.20526467
71MP0003866_abnormal_defecation1.18736257
72* MP0002722_abnormal_immune_system1.18696760
73* MP0000689_abnormal_spleen_morphology1.16807005
74MP0003453_abnormal_keratinocyte_physiol1.16366525
75* MP0002429_abnormal_blood_cell1.16081831
76MP0002332_abnormal_exercise_endurance1.14035137
77MP0005167_abnormal_blood-brain_barrier1.13351468
78MP0001853_heart_inflammation1.09117229
79* MP0001216_abnormal_epidermal_layer1.08325758
80MP0000490_abnormal_crypts_of1.07720892
81MP0005248_abnormal_Harderian_gland1.07647238
82MP0002396_abnormal_hematopoietic_system1.07228217
83MP0005166_decreased_susceptibility_to1.06319788
84MP0004264_abnormal_extraembryonic_tissu1.04730532
85MP0005275_abnormal_skin_tensile1.04648232
86* MP0003329_amyloid_beta_deposits1.03251942
87MP0005076_abnormal_cell_differentiation1.02328918
88MP0003690_abnormal_glial_cell0.97716747
89MP0009764_decreased_sensitivity_to0.96920775
90MP0010352_gastrointestinal_tract_polyps0.95942242
91MP0009278_abnormal_bone_marrow0.95472446
92MP0003795_abnormal_bone_structure0.94693620
93MP0001243_abnormal_dermal_layer0.93756369
94MP0004510_myositis0.93039053
95MP0003279_aneurysm0.93028213
96* MP0000249_abnormal_blood_vessel0.90203602
97* MP0002136_abnormal_kidney_physiology0.89758915
98MP0003221_abnormal_cardiomyocyte_apopto0.89693787
99MP0005409_darkened_coat_color0.87979446
100MP0005164_abnormal_response_to0.86839626
101MP0005365_abnormal_bile_salt0.85984923
102MP0001663_abnormal_digestive_system0.85269321
103MP0002796_impaired_skin_barrier0.84662556
104MP0005360_urolithiasis0.81339714
105* MP0000377_abnormal_hair_follicle0.80572639
106MP0000383_abnormal_hair_follicle0.80170174
107* MP0009643_abnormal_urine_homeostasis0.78328843
108MP0010678_abnormal_skin_adnexa0.77887849
109MP0009763_increased_sensitivity_to0.76860672
110MP0000703_abnormal_thymus_morphology0.76371392
111MP0000371_diluted_coat_color0.76356342
112MP0009765_abnormal_xenobiotic_induced0.75554387
113MP0001545_abnormal_hematopoietic_system0.75423488
114MP0005397_hematopoietic_system_phenotyp0.75423488
115MP0004883_abnormal_blood_vessel0.73504221
116* MP0006054_spinal_hemorrhage0.71510088
117* MP0003634_abnormal_glial_cell0.70827745
118MP0002877_abnormal_melanocyte_morpholog0.70544456
119MP0003806_abnormal_nucleotide_metabolis0.69966605
120MP0001666_abnormal_nutrient_absorption0.68289470
121MP0003045_fibrosis0.68238360
122MP0004019_abnormal_vitamin_homeostasis0.63785501
123MP0005085_abnormal_gallbladder_physiolo0.63590991
124MP0008874_decreased_physiological_sensi0.63322272

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.17390942
2Spondylolisthesis (HP:0003302)4.91914928
3* Recurrent abscess formation (HP:0002722)4.59378066
4* Recurrent bacterial skin infections (HP:0005406)4.45768193
5Metaphyseal dysplasia (HP:0100255)4.11273087
6Abnormality of macrophages (HP:0004311)3.99090224
7Vacuolated lymphocytes (HP:0001922)3.84685746
8Recurrent gram-negative bacterial infections (HP:0005420)3.72176092
9Nasal polyposis (HP:0100582)3.59158646
10Myositis (HP:0100614)3.49209778
11Absent frontal sinuses (HP:0002688)3.43188836
12Amyloidosis (HP:0011034)3.39575631
13Orchitis (HP:0100796)3.32599843
14Increased cerebral lipofuscin (HP:0011813)3.32120407
15Prostate neoplasm (HP:0100787)3.12575932
16Dysostosis multiplex (HP:0000943)3.02065053
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.01399302
18Abnormality of the nasal mucosa (HP:0000433)2.99620177
19Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.89910132
20Spinal cord lesions (HP:0100561)2.84242808
21Syringomyelia (HP:0003396)2.84242808
22Retrobulbar optic neuritis (HP:0100654)2.83656463
23Optic neuritis (HP:0100653)2.83656463
24* Recurrent skin infections (HP:0001581)2.82431773
25Gingivitis (HP:0000230)2.80580533
26Chronic otitis media (HP:0000389)2.80274445
27Recurrent fungal infections (HP:0002841)2.79572945
28Elevated erythrocyte sedimentation rate (HP:0003565)2.75915670
29Mediastinal lymphadenopathy (HP:0100721)2.67203047
30Periodontitis (HP:0000704)2.65791496
31Systemic lupus erythematosus (HP:0002725)2.63577222
32Recurrent viral infections (HP:0004429)2.60960219
33* Neurofibrillary tangles (HP:0002185)2.59843825
34Gastrointestinal infarctions (HP:0005244)2.58564388
35Abnormality of glycolipid metabolism (HP:0010969)2.55291455
36Abnormality of liposaccharide metabolism (HP:0010968)2.55291455
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.55291455
38Cervical subluxation (HP:0003308)2.53097765
39Cellulitis (HP:0100658)2.52590626
40Urinary glycosaminoglycan excretion (HP:0003541)2.50586600
41Mucopolysacchariduria (HP:0008155)2.50586600
42Pustule (HP:0200039)2.49829388
43Short middle phalanx of the 5th finger (HP:0004220)2.49814556
44Increased IgE level (HP:0003212)2.49069821
45Abnormality of the frontal sinuses (HP:0002687)2.48721239
46Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.45964380
47Hemoptysis (HP:0002105)2.44559367
48Mutism (HP:0002300)2.43860885
49Upper motor neuron abnormality (HP:0002127)2.43715208
50Autoimmune thrombocytopenia (HP:0001973)2.40698950
51Stomatitis (HP:0010280)2.40100339
52Malnutrition (HP:0004395)2.39552859
53Abnormality of polysaccharide metabolism (HP:0011012)2.37669417
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37669417
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37669417
56Interstitial pulmonary disease (HP:0006530)2.37311501
57Gingival bleeding (HP:0000225)2.34214226
58Obstructive lung disease (HP:0006536)2.33745581
59Chronic obstructive pulmonary disease (HP:0006510)2.33745581
60Hematochezia (HP:0002573)2.33358594
61Fatigue (HP:0012378)2.33046720
62Osteolytic defects of the hand bones (HP:0009699)2.32692939
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.32692939
64T lymphocytopenia (HP:0005403)2.32052371
65Loss of speech (HP:0002371)2.31082976
66Recurrent bronchitis (HP:0002837)2.28678636
67Myocardial infarction (HP:0001658)2.26140952
68Gangrene (HP:0100758)2.25747088
69Spontaneous hematomas (HP:0007420)2.23148001
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22784740
71Abnormality of T cell number (HP:0011839)2.22337293
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20770644
73Meningitis (HP:0001287)2.18161025
74Peripheral demyelination (HP:0011096)2.18035989
75Increased CSF protein (HP:0002922)2.15138197
76Arterial tortuosity (HP:0005116)2.14630760
77Hepatosplenomegaly (HP:0001433)2.08800104
78Peritonitis (HP:0002586)2.07612234
79Pulmonary embolism (HP:0002204)2.06914904
80Pulmonary infiltrates (HP:0002113)2.06817263
81Keratoconjunctivitis sicca (HP:0001097)2.06513643
82Supranuclear gaze palsy (HP:0000605)2.06439259
83Abnormality of the 2nd finger (HP:0004100)2.05937462
84Encephalitis (HP:0002383)2.05637210
85Urticaria (HP:0001025)2.05514009
86Chest pain (HP:0100749)2.04913871
87Segmental peripheral demyelination/remyelination (HP:0003481)2.04551564
88Vascular tortuosity (HP:0004948)2.02958120
89* Diminished motivation (HP:0000745)2.02649449
90Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.02184685
91Subacute progressive viral hepatitis (HP:0006572)2.01495852
92Axonal loss (HP:0003447)2.00833116
93Aortic aneurysm (HP:0004942)1.99812026
94Pathologic fracture (HP:0002756)1.99734616
95Thick nail (HP:0001805)1.99538149
96Abnormality of the prostate (HP:0008775)1.98245865
97Aortic dissection (HP:0002647)1.97831921
98Thrombocytosis (HP:0001894)1.97184282
99Episodic fever (HP:0001954)1.96939947
100Vertebral compression fractures (HP:0002953)1.96424606
101* Cerebral inclusion bodies (HP:0100314)1.95411542
102Short femoral neck (HP:0100864)1.95163412
103Arterial thrombosis (HP:0004420)1.94330390
104Petechiae (HP:0000967)1.94293532
105* Apathy (HP:0000741)1.94199526
106Broad face (HP:0000283)1.93090110
107* Inappropriate behavior (HP:0000719)1.92891039
108* Neuronal loss in central nervous system (HP:0002529)1.92057737
109Hypoplasia of the odontoid process (HP:0003311)1.88567254
110Chronic mucocutaneous candidiasis (HP:0002728)1.88387378
111Recurrent cutaneous fungal infections (HP:0011370)1.88387378
112Skin ulcer (HP:0200042)1.86003197
113Glomerulonephritis (HP:0000099)1.85995520
114Thickened calvaria (HP:0002684)1.85212850
115Cerebral aneurysm (HP:0004944)1.85145379
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84725434
117Autoimmune hemolytic anemia (HP:0001890)1.84144990
118IgM deficiency (HP:0002850)1.83361262
119Increased IgM level (HP:0003496)1.83357959
120Scanning speech (HP:0002168)1.82288003
121Vasculitis (HP:0002633)1.82113607
122J-shaped sella turcica (HP:0002680)1.81957364
123Protrusio acetabuli (HP:0003179)1.81498857
124Polyneuropathy (HP:0001271)1.80510708
125Bone pain (HP:0002653)1.79673988
126Abnormality of the pericardium (HP:0001697)1.78963122
127Abnormality of the pleura (HP:0002103)1.78463893
128Abnormality of the periventricular white matter (HP:0002518)1.78089505
129Leukocytosis (HP:0001974)1.76321118
130Abnormal albumin level (HP:0012116)1.76268628
131Hypoalbuminemia (HP:0003073)1.76268628
132Keratoconjunctivitis (HP:0001096)1.76059342
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75838185
134Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75605890
135Coxa vara (HP:0002812)1.74330734
136Abnormality of the endocardium (HP:0004306)1.73347064
137Onion bulb formation (HP:0003383)1.73153815
138Aplasia/hypoplasia of the femur (HP:0005613)1.72559487
139Slow saccadic eye movements (HP:0000514)1.71772547
140Osteomyelitis (HP:0002754)1.71282349
141Hypoplastic scapulae (HP:0000882)1.70259231
142Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70259231
143Thin bony cortex (HP:0002753)1.68726889
144* Disinhibition (HP:0000734)1.68520112
145Basal ganglia calcification (HP:0002135)1.65848832
146Anorexia (HP:0002039)1.65812619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.30298681
2MAP4K13.08143113
3MST42.82269191
4STK102.81103388
5JAK32.74693352
6TESK12.49515869
7TRIB32.40421023
8EPHB12.39197396
9BLK2.31214771
10RIPK12.29774353
11TYK22.28207357
12EEF2K2.21757668
13TBK12.17678391
14ZAP702.02907756
15IRAK31.99587066
16ACVR1B1.92761406
17PRPF4B1.90673800
18TXK1.83732054
19LRRK21.71582187
20TAOK31.68897520
21IRAK41.59768160
22KIT1.56088764
23GRK71.52811326
24MAP3K11.51942939
25TGFBR21.50181127
26YES11.43719736
27CSF1R1.43146959
28JAK11.42913909
29FGFR41.40798541
30MAP3K21.39783916
31BTK1.34915026
32IKBKE1.34841905
33MAP3K111.34375962
34GRK61.31132151
35RIPK41.27072745
36PIM21.26474090
37ITK1.25011273
38MAP3K81.24840966
39RPS6KA41.23465595
40DDR21.22708300
41MAP3K31.22310522
42MST1R1.16006522
43EPHA31.15471330
44TESK21.15376471
45IKBKB1.14705742
46TAOK11.13581056
47MAPKAPK51.13362261
48CSK1.11927672
49CDC42BPA1.10548227
50NEK91.10179339
51MAP2K31.10100315
52HCK1.10080397
53PTK61.09785992
54IRAK11.08741616
55KSR21.02005380
56SYK1.00108583
57MAP3K140.98175724
58PDGFRB0.97695629
59KSR10.97457164
60LCK0.94904023
61TAOK20.92571320
62MAP3K120.92032521
63PDGFRA0.92019532
64RPS6KA20.91957192
65MET0.91608364
66CLK10.91549002
67MARK20.91386311
68IRAK20.90970951
69SGK30.88627444
70MAPKAPK30.88455544
71FGFR30.88446196
72JAK20.88439306
73MAP3K50.85598540
74MUSK0.84785719
75PAK40.82323327
76FLT30.80181045
77PKN20.79373991
78MAP3K60.77041698
79STK240.76771948
80MAPKAPK20.76677826
81MAP3K130.75908590
82TRPM70.75801582
83PTK2B0.75679424
84MOS0.75455523
85MAP2K40.75348211
86WNK10.74394663
87MARK30.74300996
88PRKD30.74070675
89CAMKK20.73308886
90TYRO30.70860294
91TTN0.70179819
92STK30.69482850
93ERBB30.69175171
94SGK20.68980029
95MAPK40.68707266
96SIK10.68425270
97CHUK0.67896229
98LYN0.65553466
99PDK10.65325290
100FYN0.64693284
101PRKG20.62516410
102KDR0.61167968
103DYRK1B0.61019089
104PRKCD0.60546602
105PDK20.60469414
106PDK30.60332079
107PDK40.60332079
108TEC0.60305761
109NEK60.59229859
110SIK30.58618876
111RET0.57220960
112WNK40.56405104
113PDPK10.55972587
114EPHA20.54890983
115RPS6KA60.54721645
116CDK120.53271783
117ERBB40.53230036
118EPHB20.52986521
119MAPK70.51377315
120MELK0.50875131
121MAP2K20.50846876
122EGFR0.50784054
123FES0.50730431
124DYRK30.49739844
125NTRK10.48850793
126MAP2K60.48355150
127CAMK1D0.48200065
128BMPR20.47016788
129FGR0.46944304
130PIM10.46652553
131TNK20.46535627
132RPS6KL10.45490609
133RPS6KC10.45490609
134MATK0.44286685
135IGF1R0.43927003
136FER0.43755256
137MAPK110.43649746
138CDK60.43506712
139ABL10.43140811
140PASK0.42576482
141STK380.41722167
142ERBB20.41133426
143PIK3CG0.40556676
144BRD40.40257617
145SGK4940.39729585
146SGK2230.39729585

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.16848440
2Other glycan degradation_Homo sapiens_hsa005112.72039614
3Staphylococcus aureus infection_Homo sapiens_hsa051502.43659947
4Lysosome_Homo sapiens_hsa041422.33632292
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24012640
6Osteoclast differentiation_Homo sapiens_hsa043802.22241020
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.21112458
8Antigen processing and presentation_Homo sapiens_hsa046122.16728654
9Graft-versus-host disease_Homo sapiens_hsa053322.02083183
10Legionellosis_Homo sapiens_hsa051341.88617259
11Tuberculosis_Homo sapiens_hsa051521.88362902
12Pertussis_Homo sapiens_hsa051331.84205077
13Malaria_Homo sapiens_hsa051441.81492397
14Measles_Homo sapiens_hsa051621.76143328
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.68490476
16Toxoplasmosis_Homo sapiens_hsa051451.67604644
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67280898
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.65749881
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.65430509
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56389197
21Shigellosis_Homo sapiens_hsa051311.51296276
22Hematopoietic cell lineage_Homo sapiens_hsa046401.49802028
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49779140
24Autoimmune thyroid disease_Homo sapiens_hsa053201.49654744
25Salmonella infection_Homo sapiens_hsa051321.46454734
26Influenza A_Homo sapiens_hsa051641.44129506
27B cell receptor signaling pathway_Homo sapiens_hsa046621.43167303
28Sphingolipid metabolism_Homo sapiens_hsa006001.40302149
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34469403
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33795601
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30581821
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30120567
33Phagosome_Homo sapiens_hsa041451.25910958
34Pancreatic cancer_Homo sapiens_hsa052121.24667811
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23073532
36Primary immunodeficiency_Homo sapiens_hsa053401.22557348
37African trypanosomiasis_Homo sapiens_hsa051431.22490604
38Hepatitis C_Homo sapiens_hsa051601.20737498
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17235685
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17025255
41TNF signaling pathway_Homo sapiens_hsa046681.16832207
42Type I diabetes mellitus_Homo sapiens_hsa049401.14073915
43Viral myocarditis_Homo sapiens_hsa054161.12381556
44Vitamin digestion and absorption_Homo sapiens_hsa049771.12251042
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12176101
46Herpes simplex infection_Homo sapiens_hsa051681.11616172
47Renin-angiotensin system_Homo sapiens_hsa046141.09970401
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.07945015
49Rheumatoid arthritis_Homo sapiens_hsa053231.06510256
50Chemokine signaling pathway_Homo sapiens_hsa040621.05378148
51Hepatitis B_Homo sapiens_hsa051611.03871336
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03719522
53T cell receptor signaling pathway_Homo sapiens_hsa046601.02594721
54Apoptosis_Homo sapiens_hsa042101.00758713
55Steroid biosynthesis_Homo sapiens_hsa001000.98811983
56Histidine metabolism_Homo sapiens_hsa003400.95013565
57Platelet activation_Homo sapiens_hsa046110.91893621
58Mineral absorption_Homo sapiens_hsa049780.90679703
59Prolactin signaling pathway_Homo sapiens_hsa049170.90161907
60Amoebiasis_Homo sapiens_hsa051460.89078595
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87658721
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86632259
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85542172
64Endocytosis_Homo sapiens_hsa041440.84692692
65Pentose phosphate pathway_Homo sapiens_hsa000300.81981413
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80123199
67Asthma_Homo sapiens_hsa053100.80100906
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80055751
69Renal cell carcinoma_Homo sapiens_hsa052110.75936177
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75046313
71Adherens junction_Homo sapiens_hsa045200.74675693
72Fat digestion and absorption_Homo sapiens_hsa049750.73728882
73Chronic myeloid leukemia_Homo sapiens_hsa052200.72749474
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71885256
75PPAR signaling pathway_Homo sapiens_hsa033200.69231522
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67373381
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.64706879
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.64353538
79Sulfur metabolism_Homo sapiens_hsa009200.63693837
80Non-small cell lung cancer_Homo sapiens_hsa052230.63331972
81Endometrial cancer_Homo sapiens_hsa052130.62215446
82Ether lipid metabolism_Homo sapiens_hsa005650.61580351
83ErbB signaling pathway_Homo sapiens_hsa040120.58827359
84GnRH signaling pathway_Homo sapiens_hsa049120.58590302
85N-Glycan biosynthesis_Homo sapiens_hsa005100.57954329
86Dorso-ventral axis formation_Homo sapiens_hsa043200.57764115
87VEGF signaling pathway_Homo sapiens_hsa043700.57593347
88Allograft rejection_Homo sapiens_hsa053300.56759528
89Type II diabetes mellitus_Homo sapiens_hsa049300.54109957
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53170157
91Choline metabolism in cancer_Homo sapiens_hsa052310.52654961
92Collecting duct acid secretion_Homo sapiens_hsa049660.51912606
93FoxO signaling pathway_Homo sapiens_hsa040680.51244112
94* Notch signaling pathway_Homo sapiens_hsa043300.51037537
95Bladder cancer_Homo sapiens_hsa052190.50515685
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49157933
97* Neurotrophin signaling pathway_Homo sapiens_hsa047220.48732069
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47386761
99Viral carcinogenesis_Homo sapiens_hsa052030.47309641
100Linoleic acid metabolism_Homo sapiens_hsa005910.46064965
101Inositol phosphate metabolism_Homo sapiens_hsa005620.46023210
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45788047
103Glutathione metabolism_Homo sapiens_hsa004800.45511983
104HTLV-I infection_Homo sapiens_hsa051660.45291567
105Prion diseases_Homo sapiens_hsa050200.45149758
106Proteoglycans in cancer_Homo sapiens_hsa052050.45109720
107HIF-1 signaling pathway_Homo sapiens_hsa040660.43212635
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.42055370
109Small cell lung cancer_Homo sapiens_hsa052220.41843313
110Acute myeloid leukemia_Homo sapiens_hsa052210.41621488
111Epstein-Barr virus infection_Homo sapiens_hsa051690.40540992
112Estrogen signaling pathway_Homo sapiens_hsa049150.40117534
113Folate biosynthesis_Homo sapiens_hsa007900.39186725
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38869811
115Rap1 signaling pathway_Homo sapiens_hsa040150.38501858
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.37870441
117Insulin resistance_Homo sapiens_hsa049310.37244416
118Complement and coagulation cascades_Homo sapiens_hsa046100.35958012
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35370479
120Protein digestion and absorption_Homo sapiens_hsa049740.34772724
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34567468
122Galactose metabolism_Homo sapiens_hsa000520.32116726
123Glycerolipid metabolism_Homo sapiens_hsa005610.31729436
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31479052
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30883669
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.29975160

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