PSD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41634112
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.97830119
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.97830119
4antigen processing and presentation of endogenous antigen (GO:0019883)5.64126607
5regulation of gamma-delta T cell differentiation (GO:0045586)5.01648848
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77228666
7regulation of gamma-delta T cell activation (GO:0046643)4.74334884
8negative regulation of cell killing (GO:0031342)4.65186752
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65186752
10regulation of B cell receptor signaling pathway (GO:0050855)4.48494874
11negative T cell selection (GO:0043383)4.46440027
12positive thymic T cell selection (GO:0045059)4.45690578
13negative thymic T cell selection (GO:0045060)4.41232831
14detection of bacterium (GO:0016045)4.33747086
15detection of other organism (GO:0098543)4.31825334
16leukocyte aggregation (GO:0070486)4.16245956
17positive regulation of B cell differentiation (GO:0045579)4.15771220
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.15023619
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10984598
20negative regulation of T cell mediated immunity (GO:0002710)3.98940047
21B cell receptor signaling pathway (GO:0050853)3.97472960
22regulation of B cell differentiation (GO:0045577)3.96436522
23response to interleukin-15 (GO:0070672)3.95096168
24regulation of interleukin-12 biosynthetic process (GO:0045075)3.94731194
25macrophage activation involved in immune response (GO:0002281)3.91870014
26interferon-gamma production (GO:0032609)3.89398937
27T cell migration (GO:0072678)3.86025279
28thymic T cell selection (GO:0045061)3.81482671
29positive T cell selection (GO:0043368)3.77184829
30T cell selection (GO:0045058)3.73535989
31negative regulation of leukocyte mediated immunity (GO:0002704)3.67914119
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.60186288
33cellular response to interleukin-15 (GO:0071350)3.58775569
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.53655496
35detection of external biotic stimulus (GO:0098581)3.50422612
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49735998
37tolerance induction (GO:0002507)3.49678101
38activated T cell proliferation (GO:0050798)3.44767821
39NIK/NF-kappaB signaling (GO:0038061)3.42980462
40mature B cell differentiation (GO:0002335)3.40100583
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39176785
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37865310
43antigen processing and presentation via MHC class Ib (GO:0002475)3.31686397
44negative regulation of erythrocyte differentiation (GO:0045647)3.30642150
45immunoglobulin mediated immune response (GO:0016064)3.30131983
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29654587
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.29654587
48modulation by symbiont of host immune response (GO:0052553)3.29654587
49positive regulation by symbiont of host defense response (GO:0052509)3.29654587
50modulation by symbiont of host defense response (GO:0052031)3.29654587
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29654587
52regulation of T cell receptor signaling pathway (GO:0050856)3.28417684
53germinal center formation (GO:0002467)3.27056975
54regulation of T cell mediated cytotoxicity (GO:0001914)3.25834488
55antigen receptor-mediated signaling pathway (GO:0050851)3.25229795
56negative regulation of phagocytosis (GO:0050765)3.22410964
57regulation of natural killer cell mediated immunity (GO:0002715)3.22185100
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22185100
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21702635
60myeloid dendritic cell activation (GO:0001773)3.19573086
61regulation of alpha-beta T cell proliferation (GO:0046640)3.19225072
62T cell homeostasis (GO:0043029)3.18689035
63neutrophil activation involved in immune response (GO:0002283)3.15587148
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14005150
65response to type I interferon (GO:0034340)3.13212487
66mast cell activation (GO:0045576)3.11579325
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09782391
68response to host immune response (GO:0052572)3.09782391
69regulation of interferon-beta biosynthetic process (GO:0045357)3.08479240
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08218583
71cellular response to type I interferon (GO:0071357)3.08115508
72type I interferon signaling pathway (GO:0060337)3.08115508
73regulation of tolerance induction (GO:0002643)3.07831012
74T cell receptor signaling pathway (GO:0050852)3.06712790
75response to protozoan (GO:0001562)3.06100085
76regulation of regulatory T cell differentiation (GO:0045589)3.05960254
77positive regulation of interleukin-2 production (GO:0032743)3.03493069
78T cell costimulation (GO:0031295)3.02541578
79defense response to protozoan (GO:0042832)3.02281299
80detection of biotic stimulus (GO:0009595)3.01747051
81negative regulation of interleukin-12 production (GO:0032695)3.01605891
82positive regulation of isotype switching (GO:0045830)3.01292371
83regulation of mast cell degranulation (GO:0043304)2.97882348
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97370277
85lymphocyte costimulation (GO:0031294)2.96898009
86lymph node development (GO:0048535)2.96274559
87lymphocyte homeostasis (GO:0002260)2.95574614
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93929256
89cellular extravasation (GO:0045123)2.93593606
90regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93489071
91interferon-gamma-mediated signaling pathway (GO:0060333)2.93195819
92leukocyte cell-cell adhesion (GO:0007159)2.93127589
93mature B cell differentiation involved in immune response (GO:0002313)2.93057941
94negative regulation of innate immune response (GO:0045824)2.93055047
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.92027571
96detection of molecule of bacterial origin (GO:0032490)2.89448267
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89337063
98myeloid dendritic cell differentiation (GO:0043011)2.89009878
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88896305
100negative regulation of T-helper cell differentiation (GO:0045623)2.88896305
101regulation of response to interferon-gamma (GO:0060330)2.88895383
102regulation of T cell tolerance induction (GO:0002664)2.87780619
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87535716
104response to host (GO:0075136)2.87535716
105response to host defenses (GO:0052200)2.87535716
106leukocyte degranulation (GO:0043299)2.86729632
107respiratory burst (GO:0045730)2.86695098
108neutrophil activation (GO:0042119)2.86422905
109positive regulation of interferon-alpha production (GO:0032727)2.86318534
110negative regulation of interleukin-6 production (GO:0032715)2.85935259
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.85252747
112regulation of interleukin-2 biosynthetic process (GO:0045076)2.84469465
113regulation of antigen processing and presentation (GO:0002577)2.84284840
114positive regulation of antigen processing and presentation (GO:0002579)2.84136657
115microglial cell activation (GO:0001774)2.82595543
116regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82469148
117negative regulation of alpha-beta T cell activation (GO:0046636)2.82251823
118response to muramyl dipeptide (GO:0032495)2.81267289
119regulation of interferon-alpha production (GO:0032647)2.79807390
120regulation of isotype switching to IgG isotypes (GO:0048302)2.79612031
121cellular response to zinc ion (GO:0071294)2.78775802
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78024287
123positive regulation of alpha-beta T cell proliferation (GO:0046641)2.76281339
124B cell homeostasis (GO:0001782)2.75350026
125B cell mediated immunity (GO:0019724)2.72731896
126granulocyte activation (GO:0036230)2.71920189
127leukocyte homeostasis (GO:0001776)2.71018943
128myeloid cell activation involved in immune response (GO:0002275)2.71009299
129positive regulation of immunoglobulin mediated immune response (GO:0002891)2.68495481
130positive regulation of B cell mediated immunity (GO:0002714)2.68495481
131positive regulation of B cell activation (GO:0050871)2.67931095
132T cell proliferation (GO:0042098)2.67791710
133positive regulation of granulocyte differentiation (GO:0030854)2.67683263
134natural killer cell activation (GO:0030101)2.67447289
135pinocytosis (GO:0006907)2.67258116
136response to peptidoglycan (GO:0032494)2.63822771
137positive regulation of humoral immune response (GO:0002922)2.62943689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80627363
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.73722105
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40587514
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28663871
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.61533848
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55061074
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45807563
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.34165485
9MYC_22102868_ChIP-Seq_BL_Human3.20471405
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90693281
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.89868095
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84531641
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83952500
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.75313623
15VDR_21846776_ChIP-Seq_THP-1_Human2.72571680
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68664352
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.67126699
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66110069
19MYB_26560356_Chip-Seq_TH2_Human2.63058420
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55343315
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.51560499
22SCL_19346495_ChIP-Seq_HPC-7_Human2.46556495
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44543091
24MAF_26560356_Chip-Seq_TH1_Human2.44409944
25RUNX_20019798_ChIP-Seq_JUKART_Human2.42593428
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30656390
27* MYB_26560356_Chip-Seq_TH1_Human2.29453809
28* SPI1_23547873_ChIP-Seq_NB4_Human2.27767076
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27409472
30UTX_26944678_Chip-Seq_JUKART_Human2.16266214
31VDR_24763502_ChIP-Seq_THP-1_Human2.07646971
32* RUNX1_22412390_ChIP-Seq_EML_Mouse2.06925793
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05749429
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05596883
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.95271940
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.89455401
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.84362444
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83495899
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82095142
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79138123
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70911999
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69320689
43* MAF_26560356_Chip-Seq_TH2_Human1.61757018
44SPI1_23127762_ChIP-Seq_K562_Human1.60691384
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60166646
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57975962
47* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57006548
48* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56526754
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.56333837
50* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51441251
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48926146
52PU_27001747_Chip-Seq_BMDM_Mouse1.43203909
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41209938
54LXR_22292898_ChIP-Seq_THP-1_Human1.36700224
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36656485
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32338294
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31248981
58* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30946842
59CIITA_25753668_ChIP-Seq_RAJI_Human1.30456177
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29070329
61GATA1_19941826_ChIP-Seq_K562_Human1.27414125
62* KDM2B_26808549_Chip-Seq_DND41_Human1.27157080
63BCL6_27268052_Chip-Seq_Bcells_Human1.25481657
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24849226
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24735664
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24467930
67* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23478164
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23233910
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22442579
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21569342
71BCOR_27268052_Chip-Seq_Bcells_Human1.20439123
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.19278096
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18785163
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.18138553
75GATA1_22025678_ChIP-Seq_K562_Human1.17003684
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16795368
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.14501669
78* GATA3_26560356_Chip-Seq_TH2_Human1.12668677
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12411401
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10367354
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09842107
82* VDR_23849224_ChIP-Seq_CD4+_Human1.08134521
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07925936
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07716305
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06915365
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04860131
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03308876
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03222007
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02575616
90FOXP3_21729870_ChIP-Seq_TREG_Human1.02439961
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02413855
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.00785583
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96404759
94TFEB_21752829_ChIP-Seq_HELA_Human0.95899249
95GATA2_19941826_ChIP-Seq_K562_Human0.95681506
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.95087858
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94772092
98PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94439776
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93346885
100P300_27268052_Chip-Seq_Bcells_Human0.92052315
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90884775
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90479326
103CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90219413
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90200182
105* E2F1_21310950_ChIP-Seq_MCF-7_Human0.90173045
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88852130
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88695097
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88416163
109NCOR1_26117541_ChIP-Seq_K562_Human0.87588588
110P68_20966046_ChIP-Seq_HELA_Human0.86018649
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84397813
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82816040
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79723837
114KDM5A_27292631_Chip-Seq_BREAST_Human0.79107414
115MYC_18555785_ChIP-Seq_MESCs_Mouse0.78273996
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75814520
117ELK1_19687146_ChIP-ChIP_HELA_Human0.75578761
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74654334
119* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73447638
120VDR_24787735_ChIP-Seq_THP-1_Human0.73243039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03701241
2MP0005671_abnormal_response_to3.40314288
3MP0000685_abnormal_immune_system3.33478723
4MP0001800_abnormal_humoral_immune3.21484483
5MP0003763_abnormal_thymus_physiology3.20541419
6MP0001790_abnormal_immune_system3.14437023
7MP0005387_immune_system_phenotype3.14437023
8MP0003303_peritoneal_inflammation2.92732811
9MP0009785_altered_susceptibility_to2.91555833
10MP0003436_decreased_susceptibility_to2.88146764
11MP0005000_abnormal_immune_tolerance2.85267373
12MP0002452_abnormal_antigen_presenting2.80948809
13MP0002723_abnormal_immune_serum2.72755295
14MP0002420_abnormal_adaptive_immunity2.68244245
15MP0002396_abnormal_hematopoietic_system2.66982949
16MP0001819_abnormal_immune_cell2.66182016
17MP0005025_abnormal_response_to2.62426015
18MP0002398_abnormal_bone_marrow2.52902505
19MP0002419_abnormal_innate_immunity2.43732978
20MP0002166_altered_tumor_susceptibility2.39528296
21MP0002148_abnormal_hypersensitivity_rea2.34047692
22MP0003300_gastrointestinal_ulcer2.32301530
23MP0000716_abnormal_immune_system2.27596085
24MP0002405_respiratory_system_inflammati2.23980568
25MP0005464_abnormal_platelet_physiology2.19909748
26MP0000689_abnormal_spleen_morphology2.13904196
27MP0001873_stomach_inflammation2.10416648
28MP0006082_CNS_inflammation2.10032428
29MP0009333_abnormal_splenocyte_physiolog2.09063891
30MP0002722_abnormal_immune_system2.06788077
31MP0010155_abnormal_intestine_physiology2.05374762
32MP0002006_tumorigenesis2.00682761
33MP0004947_skin_inflammation1.94907018
34MP0004808_abnormal_hematopoietic_stem1.94221436
35MP0002429_abnormal_blood_cell1.92225438
36MP0001853_heart_inflammation1.88855556
37MP0003866_abnormal_defecation1.88707008
38MP0003724_increased_susceptibility_to1.87542310
39MP0000703_abnormal_thymus_morphology1.87019635
40MP0001845_abnormal_inflammatory_respons1.76334502
41MP0001545_abnormal_hematopoietic_system1.72117557
42MP0005397_hematopoietic_system_phenotyp1.72117557
43MP0004510_myositis1.64996495
44MP0000465_gastrointestinal_hemorrhage1.57739770
45MP0000490_abnormal_crypts_of1.53781535
46MP0005451_abnormal_body_composition1.52912737
47MP0009278_abnormal_bone_marrow1.51672345
48MP0008057_abnormal_DNA_replication1.51558089
49MP0003172_abnormal_lysosome_physiology1.37654560
50MP0002138_abnormal_hepatobiliary_system1.36792673
51MP0005174_abnormal_tail_pigmentation1.34449826
52MP0001533_abnormal_skeleton_physiology1.32873471
53MP0002933_joint_inflammation1.30364149
54MP0008469_abnormal_protein_level1.27731841
55MP0010352_gastrointestinal_tract_polyps1.27597060
56MP0005310_abnormal_salivary_gland1.26781256
57MP0000858_altered_metastatic_potential1.26196562
58MP0005058_abnormal_lysosome_morphology1.25701895
59MP0003448_altered_tumor_morphology1.24157341
60MP0003693_abnormal_embryo_hatching1.19334959
61MP0010307_abnormal_tumor_latency1.19117404
62MP0003191_abnormal_cellular_cholesterol1.17213951
63MP0008260_abnormal_autophagy1.14096050
64MP0003183_abnormal_peptide_metabolism1.12483497
65MP0002019_abnormal_tumor_incidence1.07776763
66MP0001851_eye_inflammation1.06191241
67MP0002277_abnormal_respiratory_mucosa0.98154430
68MP0004883_abnormal_blood_vessel0.97886810
69MP0010094_abnormal_chromosome_stability0.94377490
70MP0001986_abnormal_taste_sensitivity0.91661966
71MP0003077_abnormal_cell_cycle0.91005468
72MP0005075_abnormal_melanosome_morpholog0.88988723
73MP0000569_abnormal_digit_pigmentation0.88775257
74MP0009840_abnormal_foam_cell0.86067562
75MP0005076_abnormal_cell_differentiation0.86022773
76MP0009764_decreased_sensitivity_to0.85769737
77MP0005360_urolithiasis0.84318035
78MP0002998_abnormal_bone_remodeling0.82883784
79MP0002693_abnormal_pancreas_physiology0.77015012
80MP0001663_abnormal_digestive_system0.76119611
81MP0003111_abnormal_nucleus_morphology0.75264122
82MP0000343_altered_response_to0.74721937
83MP0009763_increased_sensitivity_to0.73724963
84MP0008007_abnormal_cellular_replicative0.73373007
85MP0005023_abnormal_wound_healing0.70144388
86MP0003566_abnormal_cell_adhesion0.69608397
87MP0003075_altered_response_to0.69121138
88MP0000015_abnormal_ear_pigmentation0.68112271
89MP0003656_abnormal_erythrocyte_physiolo0.67931590
90MP0002139_abnormal_hepatobiliary_system0.67154273
91MP0003045_fibrosis0.66665857
92MP0002095_abnormal_skin_pigmentation0.66395730
93MP0000604_amyloidosis0.66147155
94MP0004130_abnormal_muscle_cell0.65876944
95MP0005164_abnormal_response_to0.65453304
96MP0002132_abnormal_respiratory_system0.65102679
97MP0000313_abnormal_cell_death0.63941186
98MP0003252_abnormal_bile_duct0.63937417
99MP0001765_abnormal_ion_homeostasis0.63332396
100MP0005390_skeleton_phenotype0.62936511
101MP0003453_abnormal_keratinocyte_physiol0.61568825
102MP0004264_abnormal_extraembryonic_tissu0.60975172
103MP0002009_preneoplasia0.60597176
104MP0003690_abnormal_glial_cell0.60199629
105MP0000477_abnormal_intestine_morphology0.60190058
106MP0005381_digestive/alimentary_phenotyp0.59434779
107MP0005166_decreased_susceptibility_to0.58974472
108MP0009115_abnormal_fat_cell0.57152233
109MP0004957_abnormal_blastocyst_morpholog0.56931947
110MP0003795_abnormal_bone_structure0.55740786
111MP0009765_abnormal_xenobiotic_induced0.54638729
112MP0004381_abnormal_hair_follicle0.54579174
113MP0002136_abnormal_kidney_physiology0.53324480
114MP0006054_spinal_hemorrhage0.53288235
115MP0003828_pulmonary_edema0.53258733
116MP0000350_abnormal_cell_proliferation0.52687983
117MP0008873_increased_physiological_sensi0.52658972
118MP0000249_abnormal_blood_vessel0.52178491
119MP0000609_abnormal_liver_physiology0.51004579
120MP0005085_abnormal_gallbladder_physiolo0.50107751
121MP0008874_decreased_physiological_sensi0.49860426
122MP0000371_diluted_coat_color0.48747228

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.88928977
2Recurrent abscess formation (HP:0002722)4.70749775
3Chronic otitis media (HP:0000389)4.58576096
4Recurrent viral infections (HP:0004429)4.57775942
5Recurrent fungal infections (HP:0002841)4.50525009
6Elevated erythrocyte sedimentation rate (HP:0003565)4.48176756
7Myositis (HP:0100614)4.45140795
8T lymphocytopenia (HP:0005403)4.37061577
9Recurrent bacterial skin infections (HP:0005406)4.26081989
10Abnormality of T cell number (HP:0011839)4.25044800
11IgM deficiency (HP:0002850)4.08357083
12Recurrent bronchitis (HP:0002837)4.06650584
13Panhypogammaglobulinemia (HP:0003139)3.81406610
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.73723606
15Abnormality of T cells (HP:0002843)3.67137461
16Meningitis (HP:0001287)3.64197257
17Stomatitis (HP:0010280)3.63273213
18Autoimmune thrombocytopenia (HP:0001973)3.60700100
19Thrombocytosis (HP:0001894)3.58910187
20Chronic mucocutaneous candidiasis (HP:0002728)3.56403750
21Recurrent cutaneous fungal infections (HP:0011370)3.56403750
22Agammaglobulinemia (HP:0004432)3.50230705
23Vasculitis (HP:0002633)3.45744819
24Cellulitis (HP:0100658)3.43986102
25Retrobulbar optic neuritis (HP:0100654)3.42829916
26Optic neuritis (HP:0100653)3.42829916
27Orchitis (HP:0100796)3.37004087
28Mediastinal lymphadenopathy (HP:0100721)3.35700746
29Recurrent skin infections (HP:0001581)3.31664413
30Nasal polyposis (HP:0100582)3.27253279
31B lymphocytopenia (HP:0010976)3.24389933
32Abnormality of B cell number (HP:0010975)3.24389933
33Inflammation of the large intestine (HP:0002037)3.23147694
34Obstructive lung disease (HP:0006536)3.22316400
35Chronic obstructive pulmonary disease (HP:0006510)3.22316400
36Hypochromic anemia (HP:0001931)3.18110465
37Gastrointestinal inflammation (HP:0004386)3.14113184
38Abnormality of the fingertips (HP:0001211)3.12422916
39Lymphopenia (HP:0001888)3.07843206
40Pustule (HP:0200039)3.07209888
41Thyroiditis (HP:0100646)3.06946066
42Abnormality of macrophages (HP:0004311)3.04092364
43Severe combined immunodeficiency (HP:0004430)3.03208130
44Abnormality of cells of the lymphoid lineage (HP:0012140)3.00641222
45Abnormality of T cell physiology (HP:0011840)2.99014282
46Petechiae (HP:0000967)2.92771444
47Combined immunodeficiency (HP:0005387)2.91691205
48Eosinophilia (HP:0001880)2.90689218
49Leukocytosis (HP:0001974)2.86627049
50Colitis (HP:0002583)2.85740004
51Recurrent gram-negative bacterial infections (HP:0005420)2.82695822
52Abnormality of the nasal mucosa (HP:0000433)2.82543380
53Increased IgM level (HP:0003496)2.81713091
54Gastrointestinal stroma tumor (HP:0100723)2.81040583
55IgG deficiency (HP:0004315)2.80481148
56Increased IgE level (HP:0003212)2.77272185
57Arterial thrombosis (HP:0004420)2.74066768
58Spontaneous hematomas (HP:0007420)2.73416207
59Abnormality of eosinophils (HP:0001879)2.72475990
60Pulmonary infiltrates (HP:0002113)2.71425308
61Chronic diarrhea (HP:0002028)2.68777688
62Encephalitis (HP:0002383)2.66079137
63Granulocytopenia (HP:0001913)2.65743764
64Prolonged bleeding time (HP:0003010)2.63185310
65Periodontitis (HP:0000704)2.62677217
66Autoimmune hemolytic anemia (HP:0001890)2.61747961
67Interstitial pulmonary disease (HP:0006530)2.60905990
68IgA deficiency (HP:0002720)2.58940359
69Pulmonary embolism (HP:0002204)2.58131864
70Hemoptysis (HP:0002105)2.56712497
71Recurrent sinusitis (HP:0011108)2.55841904
72Hypochromic microcytic anemia (HP:0004840)2.54748458
73Osteomyelitis (HP:0002754)2.54697076
74Gingival bleeding (HP:0000225)2.52719199
75Epistaxis (HP:0000421)2.52097979
76Lymphoma (HP:0002665)2.49277706
77Chest pain (HP:0100749)2.48166873
78Chronic sinusitis (HP:0011109)2.48021032
79Papilloma (HP:0012740)2.44652792
80Verrucae (HP:0200043)2.44652792
81Abnormality of the prostate (HP:0008775)2.44112117
82Anorexia (HP:0002039)2.40049424
83Keratoconjunctivitis sicca (HP:0001097)2.39859963
84Gingivitis (HP:0000230)2.35620418
85Vacuolated lymphocytes (HP:0001922)2.33812049
86Abnormality of the pleura (HP:0002103)2.32808084
87Emphysema (HP:0002097)2.28782508
88Gangrene (HP:0100758)2.22241718
89Skin ulcer (HP:0200042)2.18502888
90Abnormal platelet function (HP:0011869)2.18211502
91Impaired platelet aggregation (HP:0003540)2.18211502
92Bronchitis (HP:0012387)2.17841560
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17107271
94Gastrointestinal infarctions (HP:0005244)2.16998949
95Hypergammaglobulinemia (HP:0010702)2.16723809
96Keratoconjunctivitis (HP:0001096)2.15355769
97Episodic fever (HP:0001954)2.15212386
98Restrictive lung disease (HP:0002091)2.10927739
99Hypoplasia of the thymus (HP:0000778)2.09796508
100Sepsis (HP:0100806)2.08700307
101Microcytic anemia (HP:0001935)2.08004443
102Amaurosis fugax (HP:0100576)2.06342893
103Recurrent pneumonia (HP:0006532)2.04451334
104Joint swelling (HP:0001386)2.04382405
105Skin rash (HP:0000988)2.03410593
106Abnormal platelet volume (HP:0011876)2.00928873
107Viral hepatitis (HP:0006562)2.00639138
108Cheilitis (HP:0100825)1.95796403
109Acute myeloid leukemia (HP:0004808)1.95093309
110Recurrent lower respiratory tract infections (HP:0002783)1.92456782
111Papilledema (HP:0001085)1.92085388
112Leukopenia (HP:0001882)1.92066721
113Increased cerebral lipofuscin (HP:0011813)1.91452340
114Urticaria (HP:0001025)1.91214859
115Increased serum ferritin (HP:0003281)1.91076639
116Arthralgia (HP:0002829)1.89682208
117Premature loss of primary teeth (HP:0006323)1.87503715
118Purpura (HP:0000979)1.85537599
119Acute hepatic failure (HP:0006554)1.85153126
120Malnutrition (HP:0004395)1.85032289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.31965321
2TXK3.54671960
3TYK22.72499797
4PRPF4B2.66592990
5NME22.61444027
6JAK32.57870091
7MAP3K142.43219565
8ZAP702.40980869
9EEF2K2.29530089
10KIT2.23835096
11STK102.23525827
12IRAK42.18019204
13TBK12.15734844
14BLK2.15166884
15BTK2.12030643
16IKBKE2.06334389
17ITK2.04386821
18TEC1.93291299
19SYK1.90866597
20GRK61.87033402
21JAK11.82799124
22TAOK31.77241051
23IRAK31.69196318
24MAP3K101.66809947
25CSF1R1.62654294
26ERN11.58291155
27HCK1.54047649
28IKBKB1.53464520
29LCK1.52344374
30FGFR41.44241107
31PKN21.40163537
32CSK1.37887255
33MAP2K31.35875586
34RIPK41.35397433
35PIM11.31960711
36LRRK21.30849111
37FLT31.22369240
38FES1.21115927
39FGFR31.20360980
40MAP3K131.19676943
41CDK121.17390268
42FGR1.13071903
43SIK21.11998027
44CLK11.09574655
45EPHB11.09187022
46LYN1.08229381
47MST41.06356933
48TRIB31.06283423
49SMG11.04633050
50CHUK1.01200893
51MAP3K11.01124874
52NLK0.97113580
53TGFBR20.96149053
54RPS6KA40.95909731
55SIK10.94804610
56PIM20.92760780
57MARK20.92388002
58CDC42BPA0.91452147
59JAK20.90050773
60PRKD20.87061759
61TLK10.86492335
62CDK40.83997253
63MARK30.80133391
64MAPK120.77929665
65BMPR20.76012944
66YES10.74901966
67PRKCQ0.72306873
68CAMKK10.72042198
69CAMKK20.70068008
70STK40.68581708
71NEK20.67286080
72TESK20.66172356
73MAP2K60.66055449
74PDPK10.65353685
75TNK20.64468064
76RET0.61978851
77KSR20.61919606
78RPS6KB20.60607020
79SIK30.60442203
80TRPM70.56598319
81MAPK70.56517190
82CDK60.56217821
83MAP2K20.55516029
84MAP3K110.54968971
85ALK0.54917659
86PIK3CG0.54461464
87PTK60.54391586
88TAOK20.54158533
89KDR0.53870563
90HIPK20.53468102
91FYN0.52132018
92BRD40.51770205
93MAP3K80.50580201
94STK240.50438870
95STK110.47038700
96SCYL20.45318909
97TTN0.45042856
98NEK90.44939924
99TAOK10.44755248
100RPS6KC10.44642474
101RPS6KL10.44642474
102ATR0.44617117
103MAP3K70.43478845
104EPHA30.43007845
105ACVR1B0.42894174
106MAPKAPK20.42698632
107MAPK110.42124871
108SGK30.41821868
109CDC70.41592220
110MAP3K20.40654642
111PDK10.40070994
112MAP3K30.39786260
113MAPK40.39544015
114STK160.38920245
115TSSK60.37734775
116TGFBR10.37484615
117ABL10.37206041
118CDK90.36940622
119PTK2B0.36096210
120MATK0.35061128
121PRKCH0.34998208
122MAP3K60.34928951
123CDK190.34337862
124RPS6KA60.34080099
125MELK0.31502251
126EGFR0.29810263
127SGK20.28574830
128CAMK1D0.28460452
129PASK0.28379042
130EIF2AK30.25972458
131IRAK10.25395114
132RIPK10.25289382
133MAPK30.24508891
134PRKCD0.24076546

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.02571391
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.71957037
3Leishmaniasis_Homo sapiens_hsa051402.65973872
4B cell receptor signaling pathway_Homo sapiens_hsa046622.65502597
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56381670
6Measles_Homo sapiens_hsa051622.49384912
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.33042604
8Osteoclast differentiation_Homo sapiens_hsa043802.27816513
9Antigen processing and presentation_Homo sapiens_hsa046122.27378814
10T cell receptor signaling pathway_Homo sapiens_hsa046602.26861094
11Hematopoietic cell lineage_Homo sapiens_hsa046402.23810486
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20729132
13Allograft rejection_Homo sapiens_hsa053302.03635611
14Graft-versus-host disease_Homo sapiens_hsa053321.89002257
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83192651
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79959382
17Herpes simplex infection_Homo sapiens_hsa051681.79239803
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78218085
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77941694
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.76871670
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66914128
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56164133
23Influenza A_Homo sapiens_hsa051641.56134699
24Toxoplasmosis_Homo sapiens_hsa051451.52911464
25Asthma_Homo sapiens_hsa053101.48078884
26Acute myeloid leukemia_Homo sapiens_hsa052211.45149239
27Legionellosis_Homo sapiens_hsa051341.44048517
28DNA replication_Homo sapiens_hsa030301.42333280
29Tuberculosis_Homo sapiens_hsa051521.37069892
30Hepatitis B_Homo sapiens_hsa051611.34484069
31Chemokine signaling pathway_Homo sapiens_hsa040621.32742784
32Apoptosis_Homo sapiens_hsa042101.31574704
33TNF signaling pathway_Homo sapiens_hsa046681.30279704
34Shigellosis_Homo sapiens_hsa051311.29462809
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29263659
36Pertussis_Homo sapiens_hsa051331.27002774
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.26335036
38Staphylococcus aureus infection_Homo sapiens_hsa051501.19610734
39Viral myocarditis_Homo sapiens_hsa054161.15215328
40Other glycan degradation_Homo sapiens_hsa005111.13960872
41Malaria_Homo sapiens_hsa051441.12939219
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11311642
43Autoimmune thyroid disease_Homo sapiens_hsa053201.11171078
44Chronic myeloid leukemia_Homo sapiens_hsa052201.11053888
45Epstein-Barr virus infection_Homo sapiens_hsa051691.09981330
46Ribosome_Homo sapiens_hsa030101.07138415
47Platelet activation_Homo sapiens_hsa046111.05009494
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99862756
49Base excision repair_Homo sapiens_hsa034100.96858655
50Hepatitis C_Homo sapiens_hsa051600.95308348
51Salmonella infection_Homo sapiens_hsa051320.92844922
52Non-homologous end-joining_Homo sapiens_hsa034500.92457749
53Viral carcinogenesis_Homo sapiens_hsa052030.92387031
54Pancreatic cancer_Homo sapiens_hsa052120.90493474
55HTLV-I infection_Homo sapiens_hsa051660.87727149
56Type I diabetes mellitus_Homo sapiens_hsa049400.85338302
57Mismatch repair_Homo sapiens_hsa034300.85230389
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82567100
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81722457
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.80901978
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79224319
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78567706
63Small cell lung cancer_Homo sapiens_hsa052220.75457116
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74383237
65Lysosome_Homo sapiens_hsa041420.73116094
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.72922966
67Prolactin signaling pathway_Homo sapiens_hsa049170.72885182
68p53 signaling pathway_Homo sapiens_hsa041150.72585866
69Non-small cell lung cancer_Homo sapiens_hsa052230.70812691
70Renal cell carcinoma_Homo sapiens_hsa052110.66400907
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64779839
72Spliceosome_Homo sapiens_hsa030400.64252346
73Dorso-ventral axis formation_Homo sapiens_hsa043200.64060716
74Homologous recombination_Homo sapiens_hsa034400.63498039
75Choline metabolism in cancer_Homo sapiens_hsa052310.60802066
76VEGF signaling pathway_Homo sapiens_hsa043700.59965939
77Rheumatoid arthritis_Homo sapiens_hsa053230.57845134
78Caffeine metabolism_Homo sapiens_hsa002320.56706988
79African trypanosomiasis_Homo sapiens_hsa051430.56543463
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56430969
81Type II diabetes mellitus_Homo sapiens_hsa049300.56304118
82Endometrial cancer_Homo sapiens_hsa052130.54631279
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53440875
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.53326963
85Colorectal cancer_Homo sapiens_hsa052100.52954595
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.49037641
87HIF-1 signaling pathway_Homo sapiens_hsa040660.48167863
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47534233
89GnRH signaling pathway_Homo sapiens_hsa049120.47404782
90Cell cycle_Homo sapiens_hsa041100.46541689
91One carbon pool by folate_Homo sapiens_hsa006700.45709590
92Systemic lupus erythematosus_Homo sapiens_hsa053220.44456792
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42722531
94Insulin resistance_Homo sapiens_hsa049310.41737381
95Notch signaling pathway_Homo sapiens_hsa043300.41450077
96FoxO signaling pathway_Homo sapiens_hsa040680.40286287
97MicroRNAs in cancer_Homo sapiens_hsa052060.40169685
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.39992691
99MAPK signaling pathway_Homo sapiens_hsa040100.39514865
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38691799
101Inositol phosphate metabolism_Homo sapiens_hsa005620.36188370
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35940393
103ABC transporters_Homo sapiens_hsa020100.34970392
104mTOR signaling pathway_Homo sapiens_hsa041500.34687658
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34602794
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34051421
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33290148
108Fanconi anemia pathway_Homo sapiens_hsa034600.32886512
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.32666747
110Linoleic acid metabolism_Homo sapiens_hsa005910.32521672
111Arachidonic acid metabolism_Homo sapiens_hsa005900.31758273
112* Endocytosis_Homo sapiens_hsa041440.31641920
113RNA transport_Homo sapiens_hsa030130.30398802
114RNA degradation_Homo sapiens_hsa030180.30217903
115Pentose phosphate pathway_Homo sapiens_hsa000300.30130404
116ErbB signaling pathway_Homo sapiens_hsa040120.29863197
117Nucleotide excision repair_Homo sapiens_hsa034200.29713549
118Phagosome_Homo sapiens_hsa041450.28538517
119Prostate cancer_Homo sapiens_hsa052150.27752089
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25934042
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24775285
122Complement and coagulation cascades_Homo sapiens_hsa046100.21707405

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