PSCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1terpenoid biosynthetic process (GO:0016114)9.49899671
2glutathione derivative biosynthetic process (GO:1901687)8.27316378
3glutathione derivative metabolic process (GO:1901685)8.27316378
4digestion (GO:0007586)8.11057727
5cilium or flagellum-dependent cell motility (GO:0001539)7.85675177
6citrulline biosynthetic process (GO:0019240)7.48990305
7motile cilium assembly (GO:0044458)7.18252451
8extracellular fibril organization (GO:0043206)7.01646774
9O-glycan processing (GO:0016266)6.92186373
10regulation of proton transport (GO:0010155)6.89798350
11cilium movement (GO:0003341)6.73004780
12digestive system process (GO:0022600)6.49983019
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.37527800
14one-carbon compound transport (GO:0019755)6.32278936
15primary alcohol catabolic process (GO:0034310)6.11145400
16regulation of phospholipase A2 activity (GO:0032429)6.03461265
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.95750074
18fibril organization (GO:0097435)5.93928028
19protein autoprocessing (GO:0016540)5.91662588
20retinoic acid metabolic process (GO:0042573)5.88325779
21epithelial cilium movement (GO:0003351)5.82143635
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.64605925
23citrulline metabolic process (GO:0000052)5.60464252
244-hydroxyproline metabolic process (GO:0019471)5.52932222
25regulation of skeletal muscle contraction (GO:0014819)5.52444883
26progesterone metabolic process (GO:0042448)5.45718177
27cellular response to arsenic-containing substance (GO:0071243)5.42194227
28negative regulation of transcription by competitive promoter binding (GO:0010944)5.37095602
29sulfation (GO:0051923)5.20077488
30muscle cell migration (GO:0014812)5.06967250
31L-ascorbic acid metabolic process (GO:0019852)5.06485263
32flavonoid metabolic process (GO:0009812)5.03982611
33face development (GO:0060324)5.02449010
34peptidyl-proline hydroxylation (GO:0019511)4.94143014
35retinol metabolic process (GO:0042572)4.89679821
36negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.88340866
37vitamin transmembrane transport (GO:0035461)4.88326739
38multicellular organismal water homeostasis (GO:0050891)4.85046980
39response to iron ion (GO:0010039)4.77089510
40lung epithelium development (GO:0060428)4.76486490
41protein O-linked glycosylation (GO:0006493)4.75664394
42xenobiotic catabolic process (GO:0042178)4.74622323
43hypotonic response (GO:0006971)4.74096982
44hemidesmosome assembly (GO:0031581)4.65695587
45negative regulation of T cell differentiation in thymus (GO:0033085)4.50442925
46cell differentiation involved in embryonic placenta development (GO:0060706)4.42664454
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.40577873
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.40577873
49regulation of transforming growth factor beta2 production (GO:0032909)4.32491819
50glandular epithelial cell differentiation (GO:0002067)4.30502684
51activation of Rac GTPase activity (GO:0032863)4.24598670
52protein retention in ER lumen (GO:0006621)4.14413133
53axoneme assembly (GO:0035082)4.12276321
54protein hydroxylation (GO:0018126)4.05526690
55water homeostasis (GO:0030104)4.03400978
56phosphatidylserine acyl-chain remodeling (GO:0036150)4.00373417
57sulfur amino acid catabolic process (GO:0000098)3.97537462
58regulation of interleukin-13 production (GO:0032656)3.95762938
59arachidonic acid secretion (GO:0050482)3.95686074
60icosanoid secretion (GO:0032309)3.95686074
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.94402049
62response to phenylpropanoid (GO:0080184)3.93327920
63left/right pattern formation (GO:0060972)3.91135187
64primary alcohol metabolic process (GO:0034308)3.90243728
65regulation of interleukin-5 production (GO:0032674)3.90004501
66gas transport (GO:0015669)3.87892721
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87134452
68antibacterial humoral response (GO:0019731)3.86115952
69COPI coating of Golgi vesicle (GO:0048205)3.81708868
70Golgi transport vesicle coating (GO:0048200)3.81708868
71kidney morphogenesis (GO:0060993)3.79491522
72ventricular cardiac muscle cell action potential (GO:0086005)3.79153976
73phospholipid scrambling (GO:0017121)3.77329896
74intestinal epithelial cell development (GO:0060576)3.77218351
75negative regulation of digestive system process (GO:0060457)3.76083186
76glutathione metabolic process (GO:0006749)3.75082443
77positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.74412337
78antimicrobial humoral response (GO:0019730)3.71663222
79positive regulation of osteoblast proliferation (GO:0033690)3.71634079
80innate immune response in mucosa (GO:0002227)3.70198957
81regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.69604449
82ethanol oxidation (GO:0006069)3.67830176
83pyrimidine-containing compound transmembrane transport (GO:0072531)3.67811028
84peptidyl-arginine modification (GO:0018195)3.67475412
85nitric oxide biosynthetic process (GO:0006809)3.64160238
86negative regulation of leukocyte chemotaxis (GO:0002689)3.63491220
87fatty acid derivative transport (GO:1901571)3.62045260
88icosanoid transport (GO:0071715)3.62045260
89C21-steroid hormone metabolic process (GO:0008207)3.59721147
90protein maturation by protein folding (GO:0022417)3.59450252
91regulation of pH (GO:0006885)3.56090580
92phosphatidylserine metabolic process (GO:0006658)3.52386286
93pH reduction (GO:0045851)3.50609887
94xenobiotic metabolic process (GO:0006805)3.46841224
95thyroid hormone metabolic process (GO:0042403)3.38551561
96positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.38221077
97epithelial cell-cell adhesion (GO:0090136)3.37289605
98apical protein localization (GO:0045176)3.36732172
99leukotriene metabolic process (GO:0006691)3.31289856
100desmosome organization (GO:0002934)3.31268017
101leukotriene biosynthetic process (GO:0019370)3.30814635
102acrosome reaction (GO:0007340)3.26875104
103response to water (GO:0009415)3.25183361
104production of molecular mediator of immune response (GO:0002440)3.24468633
105thyroid hormone generation (GO:0006590)3.23928320
106regulation of water loss via skin (GO:0033561)3.22473220
107neutrophil mediated immunity (GO:0002446)3.22053424
108positive regulation of protein localization to plasma membrane (GO:1903078)3.21703407
109phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.21602246
110cyclooxygenase pathway (GO:0019371)3.20005743
111positive regulation of extracellular matrix organization (GO:1903055)3.18002326
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16316604
113cellular glucuronidation (GO:0052695)3.14233944
114cytoskeletal anchoring at plasma membrane (GO:0007016)3.12592447
115glomerular epithelial cell development (GO:0072310)3.11836429
116branching involved in mammary gland duct morphogenesis (GO:0060444)3.11124018
117L-fucose catabolic process (GO:0042355)3.09826922
118fucose catabolic process (GO:0019317)3.09826922
119L-fucose metabolic process (GO:0042354)3.09826922
120growth hormone secretion (GO:0030252)3.08532633
121phosphatidylinositol acyl-chain remodeling (GO:0036149)3.08372392
122epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07946665
123cobalamin metabolic process (GO:0009235)3.06675041
124mucosal immune response (GO:0002385)3.02266858
125vitamin transport (GO:0051180)3.01506157
126removal of superoxide radicals (GO:0019430)3.00925737
127cellular response to superoxide (GO:0071451)3.00925737
128cellular response to oxygen radical (GO:0071450)3.00925737
129isoprenoid biosynthetic process (GO:0008299)2.99051300
130barbed-end actin filament capping (GO:0051016)2.98297838
131establishment of skin barrier (GO:0061436)2.97745446
132intestinal absorption (GO:0050892)2.96937832
133uronic acid metabolic process (GO:0006063)2.96152237
134glucuronate metabolic process (GO:0019585)2.96152237
135sodium ion homeostasis (GO:0055078)2.95615370
136decidualization (GO:0046697)2.95204242
137semaphorin-plexin signaling pathway (GO:0071526)2.94943439
138regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.94393279
139L-serine transport (GO:0015825)2.91213856
140regulation of metalloenzyme activity (GO:0048552)2.90826444
141ethanol metabolic process (GO:0006067)2.90724825
142fibrinolysis (GO:0042730)2.88731370
143ear development (GO:0043583)2.87613247
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.86589927
145establishment of monopolar cell polarity (GO:0061162)2.86589927
146alditol phosphate metabolic process (GO:0052646)2.86302920
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84367522
148asymmetric protein localization (GO:0008105)2.84356908
149mammary gland epithelial cell proliferation (GO:0033598)2.83480258
150organ or tissue specific immune response (GO:0002251)2.82775281
151chaperone mediated protein folding requiring cofactor (GO:0051085)2.82439732
152regulation of heart rate by cardiac conduction (GO:0086091)2.82285588
153regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.79959201
154receptor recycling (GO:0001881)2.79683947
155microtubule bundle formation (GO:0001578)2.79282432
156amyloid precursor protein metabolic process (GO:0042982)2.79054109
157intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.78587327
158phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.77629929
159sodium ion export (GO:0071436)2.77362695
160acid secretion (GO:0046717)2.76528046
161peptidyl-tyrosine autophosphorylation (GO:0038083)2.73864307
162regulation of cilium movement (GO:0003352)2.73389013
163excretion (GO:0007588)2.72850625
164negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.70346020
165oligosaccharide biosynthetic process (GO:0009312)2.70057832
166regulation of establishment of protein localization to plasma membrane (GO:0090003)2.69342547
167lipoxygenase pathway (GO:0019372)2.68736326
168ventricular system development (GO:0021591)2.68691748
169establishment of planar polarity (GO:0001736)2.65794999
170establishment of tissue polarity (GO:0007164)2.65794999
171negative regulation of cell fate specification (GO:0009996)2.64793912
172response to arsenic-containing substance (GO:0046685)2.63659313
173lung secretory cell differentiation (GO:0061140)2.63366412
174cellular response to gonadotropin stimulus (GO:0071371)2.62321442
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.61708662
176establishment of apical/basal cell polarity (GO:0035089)2.60995144
177serine transport (GO:0032329)2.60723622
178response to xenobiotic stimulus (GO:0009410)2.59851386
179maintenance of gastrointestinal epithelium (GO:0030277)13.3412064
180diterpenoid biosynthetic process (GO:0016102)13.1876649
181axonemal dynein complex assembly (GO:0070286)10.7969523
182epithelial structure maintenance (GO:0010669)10.3229557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human6.16718302
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.18025363
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.53890012
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.46155474
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.89131758
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.64732426
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.40630138
8* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.31034061
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.06232068
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.73229247
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57000114
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50687079
13GATA4_25053715_ChIP-Seq_YYC3_Human2.48800866
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.46389409
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39987087
16SOX2_20726797_ChIP-Seq_SW620_Human2.35612040
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.29683854
18* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.14776737
19GATA6_25053715_ChIP-Seq_YYC3_Human2.14039042
20ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.13430187
21* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00727683
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.96955537
23ZNF263_19887448_ChIP-Seq_K562_Human1.96887000
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92296797
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.90199302
26KLF5_25053715_ChIP-Seq_YYC3_Human1.83654526
27* SMC4_20622854_ChIP-Seq_HELA_Human1.83492515
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83481672
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81484690
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.76595064
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71188661
32* LXR_22292898_ChIP-Seq_THP-1_Human1.63443856
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60855735
34AHR_22903824_ChIP-Seq_MCF-7_Human1.56523180
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56061431
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55700216
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53337101
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53337101
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53337101
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52477332
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.50405711
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48231489
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.48126479
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47925113
45* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47925113
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.46697818
47* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45565891
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.41871625
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41440103
50EGR1_19032775_ChIP-ChIP_M12_Human1.39469968
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.38902063
52* GATA3_24758297_ChIP-Seq_MCF-7_Human1.38115723
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.32991741
54CTCF_27219007_Chip-Seq_Bcells_Human1.30272124
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29735996
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29640798
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28486555
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26550807
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24767032
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22873917
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22316829
62CLOCK_20551151_ChIP-Seq_293T_Human1.20770161
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19607230
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18634171
65* P68_20966046_ChIP-Seq_HELA_Human1.18390848
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17801490
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16983451
68KDM2B_26808549_Chip-Seq_K562_Human1.15778363
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15257778
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14490880
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13261364
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12354496
73* ATF3_27146783_Chip-Seq_COLON_Human1.11423477
74* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08826241
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.08680766
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08042914
77* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05570603
78* ELF5_23300383_ChIP-Seq_T47D_Human1.05012574
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04911225
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04888113
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04766012
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03405213
83STAT1_20625510_ChIP-Seq_HELA_Human1.02893042
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00996283
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00996283
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00670660
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99720880
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99666066
89* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99314863
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99094778
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98881552
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.98211287
93TCF7_22412390_ChIP-Seq_EML_Mouse0.97252230
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97090004
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96685004
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95595280
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95300926
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94781272
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94021332
100CREB1_26743006_Chip-Seq_LNCaP_Human0.93742057
101CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93290762
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92499492
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92468559
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91856629
105STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90427768
106CHD1_26751641_Chip-Seq_LNCaP_Human0.90416071
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.90322174
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.89516218
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.89357726
110GATA1_19941826_ChIP-Seq_K562_Human0.88958063
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87536261
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86414492
113AR_21909140_ChIP-Seq_LNCAP_Human0.85612543
114* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85544091
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.84918724
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84652580
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.84583497
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84062916
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83942512
120TP63_22573176_ChIP-Seq_HFKS_Human0.83749280
121* CJUN_26792858_Chip-Seq_BT549_Human0.83507239
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83479300
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83304080
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83056760
125IGF1R_20145208_ChIP-Seq_DFB_Human0.82650079
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82295969
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82217842
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82146182
129SA1_27219007_Chip-Seq_Bcells_Human0.81945106
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81841384
131BCOR_27268052_Chip-Seq_Bcells_Human0.80383901
132VDR_22108803_ChIP-Seq_LS180_Human0.79888257
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79063448
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.78936546
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.78927418
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.78927418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.89966939
2MP0001664_abnormal_digestion4.72857475
3MP0000470_abnormal_stomach_morphology3.99924280
4MP0003806_abnormal_nucleotide_metabolis3.77817224
5MP0010234_abnormal_vibrissa_follicle2.74512387
6MP0005083_abnormal_biliary_tract2.14663430
7MP0001666_abnormal_nutrient_absorption2.13566033
8MP0005623_abnormal_meninges_morphology2.00805752
9MP0008004_abnormal_stomach_pH16.1360930
10MP0000858_altered_metastatic_potential1.97789460
11MP0004264_abnormal_extraembryonic_tissu1.97162812
12MP0002653_abnormal_ependyma_morphology1.94122038
13MP0002933_joint_inflammation1.84232159
14MP0002249_abnormal_larynx_morphology1.77194294
15MP0002132_abnormal_respiratory_system1.76708232
16MP0004043_abnormal_pH_regulation1.75648984
17MP0001663_abnormal_digestive_system1.70609396
18MP0000537_abnormal_urethra_morphology1.64209532
19MP0005381_digestive/alimentary_phenotyp1.60169897
20MP0006054_spinal_hemorrhage1.53835680
21MP0005165_increased_susceptibility_to1.51209934
22MP0003186_abnormal_redox_activity1.41731802
23MP0002909_abnormal_adrenal_gland1.41165796
24MP0000678_abnormal_parathyroid_gland1.40619590
25MP0005367_renal/urinary_system_phenotyp1.37577473
26MP0000516_abnormal_urinary_system1.37577473
27MP0004883_abnormal_blood_vessel1.34545821
28MP0001346_abnormal_lacrimal_gland1.32474206
29MP0008789_abnormal_olfactory_epithelium1.30070376
30MP0000467_abnormal_esophagus_morphology1.20850145
31MP0003566_abnormal_cell_adhesion1.20301993
32MP0005085_abnormal_gallbladder_physiolo1.20227899
33MP0003705_abnormal_hypodermis_morpholog1.19794335
34MP0000477_abnormal_intestine_morphology1.19027022
35MP0004782_abnormal_surfactant_physiolog1.17351591
36MP0002796_impaired_skin_barrier1.13298575
37MP0005164_abnormal_response_to1.11033388
38MP0003191_abnormal_cellular_cholesterol1.10821654
39MP0000462_abnormal_digestive_system1.10379059
40MP0001915_intracranial_hemorrhage1.08319976
41MP0001984_abnormal_olfaction1.06874248
42MP0002932_abnormal_joint_morphology1.06199251
43MP0001765_abnormal_ion_homeostasis1.02981281
44MP0008875_abnormal_xenobiotic_pharmacok1.01949288
45MP0005248_abnormal_Harderian_gland0.99511141
46MP0003283_abnormal_digestive_organ0.97685006
47MP0001905_abnormal_dopamine_level0.95536639
48MP0000681_abnormal_thyroid_gland0.95150279
49MP0002234_abnormal_pharynx_morphology0.92240394
50MP0003453_abnormal_keratinocyte_physiol0.91224003
51MP0005666_abnormal_adipose_tissue0.90900304
52MP0000163_abnormal_cartilage_morphology0.90686548
53MP0001502_abnormal_circadian_rhythm0.90390440
54MP0010352_gastrointestinal_tract_polyps0.89834959
55MP0006072_abnormal_retinal_apoptosis0.89542149
56MP0004859_abnormal_synaptic_plasticity0.87443868
57MP0005365_abnormal_bile_salt0.84940336
58MP0009384_cardiac_valve_regurgitation0.84731004
59MP0002138_abnormal_hepatobiliary_system0.83331172
60MP0001849_ear_inflammation0.81244055
61MP0002009_preneoplasia0.81214502
62MP0002896_abnormal_bone_mineralization0.81044149
63MP0010678_abnormal_skin_adnexa0.80321474
64MP0000762_abnormal_tongue_morphology0.79102275
65MP0010386_abnormal_urinary_bladder0.78530274
66MP0004133_heterotaxia0.76983699
67MP0005670_abnormal_white_adipose0.76437814
68MP0005266_abnormal_metabolism0.76366200
69MP0004185_abnormal_adipocyte_glucose0.75635515
70MP0000490_abnormal_crypts_of0.75445142
71MP0001216_abnormal_epidermal_layer0.73431571
72MP0005394_taste/olfaction_phenotype0.73283877
73MP0005499_abnormal_olfactory_system0.73283877
74MP0002060_abnormal_skin_morphology0.72122458
75MP0002136_abnormal_kidney_physiology0.71647485
76MP0003936_abnormal_reproductive_system0.69450453
77MP0000579_abnormal_nail_morphology0.68809690
78MP0002295_abnormal_pulmonary_circulatio0.68593561
79MP0003868_abnormal_feces_composition0.67910625
80MP0002168_other_aberrant_phenotype0.67313058
81MP0010155_abnormal_intestine_physiology0.64325307
82MP0004484_altered_response_of0.64013563
83MP0005310_abnormal_salivary_gland0.62703697
84MP0005501_abnormal_skin_physiology0.61439983
85MP0005508_abnormal_skeleton_morphology0.59417030
86MP0002113_abnormal_skeleton_development0.58761071
87MP0003075_altered_response_to0.58757981
88MP0010329_abnormal_lipoprotein_level0.57894798
89MP0005275_abnormal_skin_tensile0.57738784
90MP0002277_abnormal_respiratory_mucosa0.55436894
91MP0005409_darkened_coat_color0.54900289
92MP0004858_abnormal_nervous_system0.53698253
93MP0002098_abnormal_vibrissa_morphology0.51507252
94MP0009053_abnormal_anal_canal0.50656986
95MP0000733_abnormal_muscle_development0.48901109
96MP0001542_abnormal_bone_strength0.48120627
97MP0004233_abnormal_muscle_weight0.47218826
98MP0003045_fibrosis0.46889364
99MP0002877_abnormal_melanocyte_morpholog0.46141386
100MP0001243_abnormal_dermal_layer0.43954186
101MP0001958_emphysema0.43924186
102MP0004947_skin_inflammation0.43783613
103MP0004272_abnormal_basement_membrane0.42870511
104MP0003866_abnormal_defecation0.42268756
105MP0005636_abnormal_mineral_homeostasis0.41616749
106MP0010771_integument_phenotype0.41576195
107MP0003119_abnormal_digestive_system0.41207549
108MP0002118_abnormal_lipid_homeostasis0.40620028
109MP0000534_abnormal_ureter_morphology0.40474084
110MP0000367_abnormal_coat/_hair0.40302845
111MP0004019_abnormal_vitamin_homeostasis0.39756251
112MP0010030_abnormal_orbit_morphology0.39743467
113MP0005076_abnormal_cell_differentiation0.39444492
114MP0005166_decreased_susceptibility_to0.37920384
115MP0005319_abnormal_enzyme/_coenzyme0.37806420
116MP0000566_synostosis0.37540554
117MP0003953_abnormal_hormone_level0.37061645
118MP0000465_gastrointestinal_hemorrhage0.34900669
119MP0005376_homeostasis/metabolism_phenot0.34529513
120MP0009931_abnormal_skin_appearance0.33746362
121MP0000627_abnormal_mammary_gland0.33581584
122MP0002970_abnormal_white_adipose0.32369424
123MP0002282_abnormal_trachea_morphology0.31344207
124MP0000538_abnormal_urinary_bladder0.31182869
125MP0009780_abnormal_chondrocyte_physiolo0.30562438
126MP0002139_abnormal_hepatobiliary_system0.30325924
127MP0000613_abnormal_salivary_gland0.30155616
128MP0005023_abnormal_wound_healing0.29320069
129MP0002254_reproductive_system_inflammat0.28322314
130MP0001756_abnormal_urination0.28010244
131MP0003638_abnormal_response/metabolism_0.27745350
132MP0009643_abnormal_urine_homeostasis0.26960503
133MP0000383_abnormal_hair_follicle0.26830200
134MP0005584_abnormal_enzyme/coenzyme_acti0.26813135
135MP0005408_hypopigmentation0.26771690
136* MP0002019_abnormal_tumor_incidence0.26027610
137MP0000598_abnormal_liver_morphology0.25146828
138MP0002078_abnormal_glucose_homeostasis0.25085948
139MP0003656_abnormal_erythrocyte_physiolo0.24683818
140MP0000377_abnormal_hair_follicle0.24450145
141MP0003941_abnormal_skin_development0.23917389
142MP0000609_abnormal_liver_physiology0.23220948

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.22884669
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.99627896
3Right ventricular cardiomyopathy (HP:0011663)8.47129319
4Chronic bronchitis (HP:0004469)8.37980451
5Abnormality of cells of the erythroid lineage (HP:0012130)8.28930072
6Abnormal respiratory motile cilium physiology (HP:0012261)7.63270146
7Abnormal respiratory epithelium morphology (HP:0012253)7.58755403
8Abnormal respiratory motile cilium morphology (HP:0005938)7.58755403
9Rhinitis (HP:0012384)7.26731479
10Abnormal ciliary motility (HP:0012262)7.12803911
11Dynein arm defect of respiratory motile cilia (HP:0012255)7.04938801
12Absent/shortened dynein arms (HP:0200106)7.04938801
13Bronchiectasis (HP:0002110)5.80793119
14Fragile nails (HP:0001808)5.04448284
15Abnormality of the nasal mucosa (HP:0000433)5.03000807
16Gout (HP:0001997)4.90583158
17Deep venous thrombosis (HP:0002625)4.78297105
18Pustule (HP:0200039)4.75865752
19Megaloblastic anemia (HP:0001889)4.28882547
20Onycholysis (HP:0001806)4.22862814
21Abnormality of the vitamin B12 metabolism (HP:0004341)4.13479820
22Milia (HP:0001056)4.02603584
23Woolly hair (HP:0002224)3.87131361
24Bronchitis (HP:0012387)3.86095508
25Abnormality of vitamin B metabolism (HP:0004340)3.86008575
26Plantar hyperkeratosis (HP:0007556)3.71572057
27Abnormality of vitamin metabolism (HP:0100508)3.69882999
28Atrophic scars (HP:0001075)3.62561182
29Palpitations (HP:0001962)3.47227335
30Aortic aneurysm (HP:0004942)3.33318811
31Syncope (HP:0001279)3.26080615
32Aortic dissection (HP:0002647)3.25304622
33Ulnar bowing (HP:0003031)3.25150079
34Male infertility (HP:0003251)3.20792063
35Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19279240
36Short nail (HP:0001799)3.13018247
37Hyperkalemia (HP:0002153)3.12976964
38Infertility (HP:0000789)3.10118290
39Renal salt wasting (HP:0000127)3.09627357
40Ventricular fibrillation (HP:0001663)2.98933707
41Glomerulosclerosis (HP:0000096)2.96648574
42Malnutrition (HP:0004395)2.96238132
43Alopecia of scalp (HP:0002293)2.93788964
44Recurrent otitis media (HP:0000403)2.85866442
45Goiter (HP:0000853)2.85468095
46Hyperuricemia (HP:0002149)2.82056717
47Increased purine levels (HP:0004368)2.82056717
48Hyperaldosteronism (HP:0000859)2.72981615
49Chronic sinusitis (HP:0011109)2.69595940
50Recurrent sinusitis (HP:0011108)2.69330613
51Pili torti (HP:0003777)2.68891173
52Abnormality of renin-angiotensin system (HP:0000847)2.67815937
53Abnormality of chloride homeostasis (HP:0011422)2.67283055
54Abnormality of purine metabolism (HP:0004352)2.67083542
55Decreased circulating renin level (HP:0003351)2.65776225
56Back pain (HP:0003418)2.63992166
57Down-sloping shoulders (HP:0200021)2.59218230
58Arterial tortuosity (HP:0005116)2.57841333
59Vascular calcification (HP:0004934)2.53288392
60Upper limb amyotrophy (HP:0009129)2.51336224
61Distal upper limb amyotrophy (HP:0007149)2.51336224
62Intrahepatic cholestasis (HP:0001406)2.50100260
63Ventricular arrhythmia (HP:0004308)2.45865137
64Tubulointerstitial fibrosis (HP:0005576)2.42877968
65Palmoplantar hyperkeratosis (HP:0000972)2.41413130
66Tubulointerstitial nephritis (HP:0001970)2.39016988
67Abnormal blistering of the skin (HP:0008066)2.38484385
68Broad face (HP:0000283)2.38436336
69Curly hair (HP:0002212)2.38142829
70Bronchomalacia (HP:0002780)2.37015160
71Atelectasis (HP:0100750)2.34060077
72Frequent falls (HP:0002359)2.32120971
73Cardiovascular calcification (HP:0011915)2.32082832
74Flat acetabular roof (HP:0003180)2.31404824
75Vascular tortuosity (HP:0004948)2.30274872
76Hyponatremia (HP:0002902)2.29603257
77Ventricular tachycardia (HP:0004756)2.27323120
78Cerebral aneurysm (HP:0004944)2.24549587
79Nail dystrophy (HP:0008404)2.22404556
80Hemorrhage of the eye (HP:0011885)2.21704258
81Lip pit (HP:0100267)2.17278135
82Palmar hyperkeratosis (HP:0010765)2.16028994
83Turricephaly (HP:0000262)2.14956853
84Abnormality of the gastric mucosa (HP:0004295)2.14889544
85Gastrointestinal dysmotility (HP:0002579)2.13179378
86Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10423768
87Vertebral hypoplasia (HP:0008417)2.10423768
88Cervical subluxation (HP:0003308)2.08079024
89Bowed forearm bones (HP:0003956)2.06561768
90Bowing of the arm (HP:0006488)2.06561768
91Aneurysm (HP:0002617)2.04597104
92Micronodular cirrhosis (HP:0001413)2.03368791
93Popliteal pterygium (HP:0009756)2.02900817
94Focal segmental glomerulosclerosis (HP:0000097)2.01960944
95Spinal cord compression (HP:0002176)2.01866197
96Choroideremia (HP:0001139)2.00364328
97Hyperactive renin-angiotensin system (HP:0000841)1.98403416
98Hoarse voice (HP:0001609)1.96069431
99Tubular atrophy (HP:0000092)1.95986314
100Distal lower limb muscle weakness (HP:0009053)1.95513480
101Hand muscle atrophy (HP:0009130)1.95249493
102Abnormality of the dental root (HP:0006486)1.95184065
103Taurodontia (HP:0000679)1.95184065
104Abnormality of permanent molar morphology (HP:0011071)1.95184065
105Interstitial pulmonary disease (HP:0006530)1.94551991
106Ankle contracture (HP:0006466)1.93564252
107Mucopolysacchariduria (HP:0008155)1.92865550
108Urinary glycosaminoglycan excretion (HP:0003541)1.92865550
109Neoplasm of the heart (HP:0100544)1.92777132
110Abnormal hemoglobin (HP:0011902)1.91044969
111Rectal prolapse (HP:0002035)1.90215118
112Abnormal vertebral ossification (HP:0100569)1.89510409
113Abnormality of nucleobase metabolism (HP:0010932)1.85554332
114Humeroradial synostosis (HP:0003041)1.81099986
115Synostosis involving the elbow (HP:0003938)1.81099986
116Spastic diplegia (HP:0001264)1.80586730
117Chronic otitis media (HP:0000389)1.80259360
118Abnormal cartilage morphology (HP:0002763)1.80039593
119Acanthosis nigricans (HP:0000956)1.79832753
120Occipital encephalocele (HP:0002085)1.79140777
121Pterygium (HP:0001059)1.78626100
122Amelogenesis imperfecta (HP:0000705)1.78027778
123Fragile skin (HP:0001030)1.77469378
124Vaginal fistula (HP:0004320)1.77202250
125Abnormality of carpal bone ossification (HP:0006257)1.76628802
126Abnormality of molar morphology (HP:0011070)1.75943486
127Abnormality of molar (HP:0011077)1.75943486
128Protrusio acetabuli (HP:0003179)1.70731404
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.70304717
130Esophageal atresia (HP:0002032)1.69126676
131Nasal polyposis (HP:0100582)1.68533649
132Abnormality of the distal phalanges of the toes (HP:0010182)1.67761087
133Abnormality of the 2nd finger (HP:0004100)1.67498738
134Bifid scrotum (HP:0000048)1.67204918
135Stridor (HP:0010307)1.67053489
136Abnormality of the dental pulp (HP:0006479)1.66709289
137Hypoplasia of dental enamel (HP:0006297)1.65057030
138Cystic liver disease (HP:0006706)1.65056260
139Hyperparathyroidism (HP:0000843)1.64965995
140Choanal stenosis (HP:0000452)1.64215438
141Growth hormone excess (HP:0000845)1.64135959
142Scapular winging (HP:0003691)1.63447048
143Hypotension (HP:0002615)1.62551407
144Axonal loss (HP:0003447)1.62454270
145Erythema (HP:0010783)1.60985619
146Ureteral stenosis (HP:0000071)1.60332260
147Bell-shaped thorax (HP:0001591)1.60127979
148Abnormality of sodium homeostasis (HP:0010931)1.59635071
149Stage 5 chronic kidney disease (HP:0003774)1.58428012
150Annular pancreas (HP:0001734)1.58426561
151Coronal craniosynostosis (HP:0004440)1.58331920
152Hyperammonemia (HP:0001987)1.57984494
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57977685
154Abnormality of polysaccharide metabolism (HP:0011012)1.57977685
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57977685
156Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.57869196
157Ketoacidosis (HP:0001993)1.57820553
158Short hallux (HP:0010109)1.57534890
159Diaphragmatic weakness (HP:0009113)1.56918872
160Polar cataract (HP:0010696)1.55599659
161Glucose intolerance (HP:0000833)1.53817936
162Abnormal hand bone ossification (HP:0010660)1.53608388
163Tubulointerstitial abnormality (HP:0001969)1.52476403
164Abnormality of the renal medulla (HP:0100957)1.52323625
165Distal lower limb amyotrophy (HP:0008944)1.51513657
166Adrenal overactivity (HP:0002717)1.47720415
167Abnormal ossification of hand bones (HP:0005921)1.47024621
168Abnormal hair laboratory examination (HP:0003328)1.44115531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB48.05923195
2MST44.59337286
3EPHA24.52639757
4MST1R4.51691136
5TRIB32.31059125
6MAP3K92.28999917
7MYLK2.19148022
8PKN22.15279890
9DDR22.09960768
10TRPM71.95739500
11CDK81.88650214
12MET1.84136345
13ICK1.73056138
14MAP3K21.69980475
15LRRK21.67826811
16FER1.66675766
17TTN1.66112813
18ERBB31.63443355
19KSR21.58383846
20FLT31.51625836
21MAP3K121.44873623
22EPHB21.43474550
23SIK11.37984761
24PIK3CG1.28617464
25MATK1.26232324
26LMTK21.24773389
27BCKDK1.23636684
28TESK11.23366474
29ARAF1.22377181
30PTK61.21698471
31BMX1.21324157
32MAP3K131.19744302
33PTK21.16800975
34STK101.12660813
35NME21.10296099
36MAP2K11.10163982
37PDGFRB1.09434030
38FRK1.03728349
39STK391.02246625
40GRK51.02067443
41DMPK1.00568314
42ZAP700.98601465
43MAP3K70.98543052
44RIPK10.97815789
45PAK40.96341981
46PAK30.92962754
47MAP3K30.92387142
48EEF2K0.92155476
49TYRO30.90045257
50PRKCI0.88767266
51SMG10.88573347
52LATS10.87147437
53NUAK10.85687682
54MAP3K110.85503905
55WNK40.82408604
56PDGFRA0.82015012
57TAOK10.81403342
58AKT30.81206520
59MAP2K20.79531816
60ERN10.77246318
61CSK0.77021497
62RPS6KB20.73921960
63FGR0.73918197
64ROCK20.73546845
65EPHB10.72934447
66RIPK40.72506729
67MARK20.66544304
68NEK60.66378444
69PRKG20.66050872
70PIM20.65955880
71CDK90.64572758
72STK380.63710901
73MAPK150.62392115
74IRAK30.62010902
75FYN0.61720525
76ERBB20.59522632
77PAK20.59173619
78KSR10.58902539
79PTK2B0.57729998
80LIMK10.55526448
81RPS6KL10.54528629
82RPS6KC10.54528629
83TBK10.53801351
84DYRK1B0.53689503
85EGFR0.52513700
86MAP3K60.52478180
87CDC42BPA0.49672405
88RPS6KA20.49657196
89SRC0.49285590
90PDK30.47867911
91PDK40.47867911
92STK240.47719027
93PDK20.47180796
94CDK60.46923389
95PBK0.45775790
96MELK0.45695378
97MAPKAPK30.45275926
98LATS20.44193161
99SIK30.44052162
100RPS6KA60.44038671
101RAF10.43411961
102FGFR10.43113248
103PHKG10.42435742
104PHKG20.42435742
105NME10.41528831
106MAP3K80.41168592
107NEK10.38757793
108PIK3CA0.38752059
109PAK10.35924570
110RPS6KA10.35810167
111MAP2K60.35260820
112ROCK10.34645828
113DAPK10.34548603
114ILK0.32656527
115CDK70.32424495
116EIF2AK10.32205157
117GSK3A0.31071590
118PRKCD0.29554137
119CAMK2G0.29409234
120PDPK10.29387656
121MAP3K10.28913744
122STK30.28569534
123EPHA30.28008514
124IGF1R0.27036676
125PRKD10.26118596
126UHMK10.26027666
127HIPK20.25074907
128CAMK2B0.24905720
129BRAF0.24883102
130CSF1R0.24578983
131NTRK10.23450452
132PRKD20.18278350
133MTOR0.13613603
134MAP2K40.12296076
135CHUK0.10429666
136ABL20.10060358
137STK160.09433114
138PRKAA20.07216762

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.77589861
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.82930380
3Collecting duct acid secretion_Homo sapiens_hsa049664.32692715
4Chemical carcinogenesis_Homo sapiens_hsa052044.30920978
5Gastric acid secretion_Homo sapiens_hsa049714.29734331
6Glutathione metabolism_Homo sapiens_hsa004803.73947520
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.36068677
8Sulfur metabolism_Homo sapiens_hsa009203.34658120
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.61721001
10Fat digestion and absorption_Homo sapiens_hsa049752.31023123
11Vitamin digestion and absorption_Homo sapiens_hsa049771.94050405
12Phenylalanine metabolism_Homo sapiens_hsa003601.77867593
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.72788437
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72191640
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65389037
16Caffeine metabolism_Homo sapiens_hsa002321.60606067
17Starch and sucrose metabolism_Homo sapiens_hsa005001.60284911
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.59568958
19Linoleic acid metabolism_Homo sapiens_hsa005911.55082674
20Histidine metabolism_Homo sapiens_hsa003401.38118253
21Notch signaling pathway_Homo sapiens_hsa043301.37785731
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35030365
23Circadian rhythm_Homo sapiens_hsa047101.33775562
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22348425
25Vitamin B6 metabolism_Homo sapiens_hsa007501.19459767
26Mineral absorption_Homo sapiens_hsa049781.16895136
27Sphingolipid metabolism_Homo sapiens_hsa006001.16450550
28Pancreatic secretion_Homo sapiens_hsa049721.12931736
29Tight junction_Homo sapiens_hsa045301.11529296
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09147936
31Adherens junction_Homo sapiens_hsa045201.07789712
32Retinol metabolism_Homo sapiens_hsa008301.07397959
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07389646
34beta-Alanine metabolism_Homo sapiens_hsa004101.06535156
35Bladder cancer_Homo sapiens_hsa052191.01756319
36Ether lipid metabolism_Homo sapiens_hsa005651.01014312
37Fatty acid degradation_Homo sapiens_hsa000710.97174241
38Axon guidance_Homo sapiens_hsa043600.94543661
39Tyrosine metabolism_Homo sapiens_hsa003500.93802578
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92259537
41Pancreatic cancer_Homo sapiens_hsa052120.90503932
42Chronic myeloid leukemia_Homo sapiens_hsa052200.86142082
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85945068
44Arginine biosynthesis_Homo sapiens_hsa002200.85147103
45Thyroid hormone synthesis_Homo sapiens_hsa049180.80137433
46Sulfur relay system_Homo sapiens_hsa041220.77649240
47Arachidonic acid metabolism_Homo sapiens_hsa005900.77365618
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77046607
49N-Glycan biosynthesis_Homo sapiens_hsa005100.76591549
50Hepatitis C_Homo sapiens_hsa051600.75247256
51Propanoate metabolism_Homo sapiens_hsa006400.74956978
52Fatty acid biosynthesis_Homo sapiens_hsa000610.74574040
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73867868
54Bile secretion_Homo sapiens_hsa049760.73409816
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71419211
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69504803
57Pyruvate metabolism_Homo sapiens_hsa006200.68584965
58Nitrogen metabolism_Homo sapiens_hsa009100.68499905
59Huntingtons disease_Homo sapiens_hsa050160.67011011
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.66519921
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65973632
62Thyroid cancer_Homo sapiens_hsa052160.65714499
63Salivary secretion_Homo sapiens_hsa049700.64358173
64Complement and coagulation cascades_Homo sapiens_hsa046100.63076022
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.62785944
66Hippo signaling pathway_Homo sapiens_hsa043900.62552056
67Proteoglycans in cancer_Homo sapiens_hsa052050.62495158
68Fatty acid metabolism_Homo sapiens_hsa012120.62204871
69Vibrio cholerae infection_Homo sapiens_hsa051100.61663158
70Glycerolipid metabolism_Homo sapiens_hsa005610.58988702
71ECM-receptor interaction_Homo sapiens_hsa045120.58755665
72Carbon metabolism_Homo sapiens_hsa012000.58440751
73Folate biosynthesis_Homo sapiens_hsa007900.58405639
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58028035
75Biosynthesis of amino acids_Homo sapiens_hsa012300.57119168
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54739604
77Focal adhesion_Homo sapiens_hsa045100.54613873
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.54133390
79Fructose and mannose metabolism_Homo sapiens_hsa000510.53637890
80Cocaine addiction_Homo sapiens_hsa050300.53399052
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51929677
82Choline metabolism in cancer_Homo sapiens_hsa052310.49847819
83Shigellosis_Homo sapiens_hsa051310.48645014
84Inositol phosphate metabolism_Homo sapiens_hsa005620.47948521
85Insulin resistance_Homo sapiens_hsa049310.47524659
86ABC transporters_Homo sapiens_hsa020100.46723204
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46488272
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45891176
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45822275
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44234985
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43162338
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42071236
93Prostate cancer_Homo sapiens_hsa052150.40924250
94VEGF signaling pathway_Homo sapiens_hsa043700.39743945
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38163614
96Lysosome_Homo sapiens_hsa041420.37205310
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36805893
98Dorso-ventral axis formation_Homo sapiens_hsa043200.36158383
99Amoebiasis_Homo sapiens_hsa051460.35567395
100Peroxisome_Homo sapiens_hsa041460.35269055
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34535453
102Insulin signaling pathway_Homo sapiens_hsa049100.32847232
103Oxidative phosphorylation_Homo sapiens_hsa001900.32547286
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32260812
105TNF signaling pathway_Homo sapiens_hsa046680.32201474
106ErbB signaling pathway_Homo sapiens_hsa040120.31476256
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31178747
108Pentose phosphate pathway_Homo sapiens_hsa000300.30438341
109Taste transduction_Homo sapiens_hsa047420.30338178
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30208178
111Salmonella infection_Homo sapiens_hsa051320.29299323
112Endometrial cancer_Homo sapiens_hsa052130.28386692
113Metabolic pathways_Homo sapiens_hsa011000.27338439
114Small cell lung cancer_Homo sapiens_hsa052220.25959854
115PPAR signaling pathway_Homo sapiens_hsa033200.24346695
116TGF-beta signaling pathway_Homo sapiens_hsa043500.24102360
117Prolactin signaling pathway_Homo sapiens_hsa049170.22842560
118Butanoate metabolism_Homo sapiens_hsa006500.22426767
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19052357
120Renal cell carcinoma_Homo sapiens_hsa052110.18171650
121GnRH signaling pathway_Homo sapiens_hsa049120.17740796
122Estrogen signaling pathway_Homo sapiens_hsa049150.17652653
123Arginine and proline metabolism_Homo sapiens_hsa003300.17435812
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.15671009
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.14381095
126Endocytosis_Homo sapiens_hsa041440.12832334
127HIF-1 signaling pathway_Homo sapiens_hsa040660.12808802
128Platelet activation_Homo sapiens_hsa046110.12557881
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11299692
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10605115
131Basal cell carcinoma_Homo sapiens_hsa052170.10521331
132mTOR signaling pathway_Homo sapiens_hsa041500.09969292
133Dilated cardiomyopathy_Homo sapiens_hsa054140.09966685
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09776531
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09464478
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08990760
137Toxoplasmosis_Homo sapiens_hsa051450.08844543
138Galactose metabolism_Homo sapiens_hsa000520.08715296

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