PRSS55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.86238499
2acrosome assembly (GO:0001675)9.09173435
3sperm-egg recognition (GO:0035036)8.59627199
4fusion of sperm to egg plasma membrane (GO:0007342)8.49394644
5multicellular organism reproduction (GO:0032504)8.20279868
6cell-cell recognition (GO:0009988)7.61238226
7motile cilium assembly (GO:0044458)7.60689170
8binding of sperm to zona pellucida (GO:0007339)7.59700570
9epithelial cilium movement (GO:0003351)7.59687734
10spermatid development (GO:0007286)7.48678838
11axonemal dynein complex assembly (GO:0070286)7.24731781
12regulation of cilium movement (GO:0003352)7.00471018
13reproduction (GO:0000003)6.75520454
14plasma membrane fusion (GO:0045026)6.65253590
15cilium or flagellum-dependent cell motility (GO:0001539)6.23113278
16cilium movement (GO:0003341)6.03772329
17microtubule depolymerization (GO:0007019)5.98526452
18sperm capacitation (GO:0048240)5.89578698
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.81528332
20single fertilization (GO:0007338)5.67636404
21male meiosis (GO:0007140)5.24333906
22spermatogenesis (GO:0007283)5.17648796
23male gamete generation (GO:0048232)5.15861102
24organic cation transport (GO:0015695)5.12400809
25response to pheromone (GO:0019236)5.06792196
26piRNA metabolic process (GO:0034587)4.94490965
27behavioral response to nicotine (GO:0035095)4.90134973
28calcium ion-dependent exocytosis (GO:0017156)4.89600810
29gamete generation (GO:0007276)4.76361496
30cellular ketone body metabolic process (GO:0046950)4.75928730
31synaptonemal complex organization (GO:0070193)4.75158191
32synaptonemal complex assembly (GO:0007130)4.59117444
33fertilization (GO:0009566)4.51073582
34negative regulation of inclusion body assembly (GO:0090084)4.49488672
35ketone body metabolic process (GO:1902224)4.16466337
36germ cell development (GO:0007281)4.07211639
37glycerol ether metabolic process (GO:0006662)4.00378979
38cellular process involved in reproduction in multicellular organism (GO:0022412)3.98187188
39spermatid nucleus differentiation (GO:0007289)3.96310471
40cell recognition (GO:0008037)3.94606455
41protein K11-linked deubiquitination (GO:0035871)3.86756769
42regulation of inclusion body assembly (GO:0090083)3.82050315
43ether metabolic process (GO:0018904)3.77709573
44multicellular organismal reproductive process (GO:0048609)3.74986405
45single strand break repair (GO:0000012)3.74936087
46chromosome organization involved in meiosis (GO:0070192)3.73136573
47establishment of protein localization to Golgi (GO:0072600)3.63549877
48DNA packaging (GO:0006323)3.62738859
49protein targeting to Golgi (GO:0000042)3.53749098
50sequestering of actin monomers (GO:0042989)3.53429552
51regulation of neuron projection regeneration (GO:0070570)3.49377835
52regulation of axon regeneration (GO:0048679)3.49377835
53chromosome condensation (GO:0030261)3.49283438
54male meiosis I (GO:0007141)3.43607616
55DNA methylation involved in gamete generation (GO:0043046)3.38796474
56DNA deamination (GO:0045006)3.37185212
57regulation of spindle checkpoint (GO:0090231)3.35880046
58retrograde transport, vesicle recycling within Golgi (GO:0000301)3.34765734
59fucose catabolic process (GO:0019317)3.33052852
60L-fucose metabolic process (GO:0042354)3.33052852
61L-fucose catabolic process (GO:0042355)3.33052852
62protein localization to cilium (GO:0061512)3.30684885
63nephron epithelium morphogenesis (GO:0072088)3.26599875
64nephron tubule morphogenesis (GO:0072078)3.26599875
65ventricular system development (GO:0021591)3.26501766
66intraciliary transport (GO:0042073)3.26092657
67synapsis (GO:0007129)3.25919876
68cilium assembly (GO:0042384)3.22136319
69cilium organization (GO:0044782)3.19036310
70regulation of microtubule-based movement (GO:0060632)3.18337142
71microtubule polymerization or depolymerization (GO:0031109)3.15896916
72protein-cofactor linkage (GO:0018065)3.15475045
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08332276
74urinary tract smooth muscle contraction (GO:0014848)3.07917622
75cAMP catabolic process (GO:0006198)3.07230101
76microtubule severing (GO:0051013)3.05888289
77cornea development in camera-type eye (GO:0061303)3.03907143
78rRNA methylation (GO:0031167)3.03861476
79regulation of mitotic spindle checkpoint (GO:1903504)3.03499703
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03499703
81indolalkylamine metabolic process (GO:0006586)3.01810228
82multicellular organismal development (GO:0007275)3.01660039
83negative regulation of mast cell activation (GO:0033004)3.01289548
84ubiquinone biosynthetic process (GO:0006744)3.00022951
85protein localization to Golgi apparatus (GO:0034067)2.99700367
86rRNA modification (GO:0000154)2.98352260
87indole-containing compound catabolic process (GO:0042436)2.97828497
88indolalkylamine catabolic process (GO:0046218)2.97828497
89tryptophan catabolic process (GO:0006569)2.97828497
90centriole assembly (GO:0098534)2.96678948
91kynurenine metabolic process (GO:0070189)2.94536110
92amine catabolic process (GO:0009310)2.92327859
93cellular biogenic amine catabolic process (GO:0042402)2.92327859
94protein polyglutamylation (GO:0018095)2.92254406
95musculoskeletal movement (GO:0050881)2.91720590
96multicellular organismal movement (GO:0050879)2.91720590
97meiotic nuclear division (GO:0007126)2.91613762
98startle response (GO:0001964)2.90241173
99cyclic nucleotide catabolic process (GO:0009214)2.86170083
100nonmotile primary cilium assembly (GO:0035058)2.83290821
101regulation of neurotransmitter uptake (GO:0051580)2.80973369
102cellular component assembly involved in morphogenesis (GO:0010927)2.78091228
103centriole replication (GO:0007099)2.77257138
104regulation of mesoderm development (GO:2000380)2.76202412
105detection of light stimulus involved in sensory perception (GO:0050962)2.75647564
106detection of light stimulus involved in visual perception (GO:0050908)2.75647564
107polyol catabolic process (GO:0046174)2.73848428
108regulation of systemic arterial blood pressure by hormone (GO:0001990)2.72363254
109regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.72363254
110endocrine process (GO:0050886)2.72363254
111left/right pattern formation (GO:0060972)2.71696267
112C4-dicarboxylate transport (GO:0015740)2.71239630
113positive regulation of cellular amide metabolic process (GO:0034250)2.68660581
114nitric oxide mediated signal transduction (GO:0007263)2.68438991
115platelet dense granule organization (GO:0060155)2.68330703
116ubiquinone metabolic process (GO:0006743)2.68065013
117regulation of centriole replication (GO:0046599)2.67747049
118water-soluble vitamin biosynthetic process (GO:0042364)2.66467507
119alanine transport (GO:0032328)2.65983865
120serotonin receptor signaling pathway (GO:0007210)2.59953569
121negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.59774693
122calcium ion import (GO:0070509)2.59057067
123neuronal action potential (GO:0019228)2.58906577
124NAD biosynthetic process (GO:0009435)2.57880062
125NADH dehydrogenase complex assembly (GO:0010257)2.57405764
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57405764
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.57405764
128lactate metabolic process (GO:0006089)2.56674745
129ATP hydrolysis coupled proton transport (GO:0015991)2.55966128
130energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55966128
131superoxide anion generation (GO:0042554)2.55138415
132protein refolding (GO:0042026)2.53975164
133regulation of sarcomere organization (GO:0060297)2.52935837
134rRNA catabolic process (GO:0016075)2.51129313
135meiosis I (GO:0007127)2.50634545
136positive regulation of monocyte chemotaxis (GO:0090026)2.48938031
137meiotic cell cycle (GO:0051321)2.47168192
138primary amino compound metabolic process (GO:1901160)2.46542666
139positive regulation of guanylate cyclase activity (GO:0031284)2.46234009
140renal tubule morphogenesis (GO:0061333)2.45904044
141RNA destabilization (GO:0050779)2.45868780
142limb bud formation (GO:0060174)2.45117195
143negative regulation of neurological system process (GO:0031645)2.44320000
144seminiferous tubule development (GO:0072520)2.43504411
145RNA localization (GO:0006403)2.39124395
146monoubiquitinated protein deubiquitination (GO:0035520)2.35874202
147cilium morphogenesis (GO:0060271)2.33119864
148axoneme assembly (GO:0035082)2.32971457
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32516204
150phagosome maturation (GO:0090382)2.30212221
151polyamine biosynthetic process (GO:0006596)2.29969031
152polyol transport (GO:0015791)2.29478279
153DNA double-strand break processing (GO:0000729)2.27785611
154regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.25824321
155positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.24223015
156cullin deneddylation (GO:0010388)2.21301662
157meiotic cell cycle process (GO:1903046)2.18824706
158sperm motility (GO:0030317)10.6687810
159cell wall macromolecule catabolic process (GO:0016998)10.4109294
160cell wall macromolecule metabolic process (GO:0044036)10.4109294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76017055
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.55598180
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.79355213
4EZH2_22144423_ChIP-Seq_EOC_Human3.58488153
5GBX2_23144817_ChIP-Seq_PC3_Human3.10824915
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90371317
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.66682314
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.56312594
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49254890
10VDR_22108803_ChIP-Seq_LS180_Human2.40477672
11TAF15_26573619_Chip-Seq_HEK293_Human2.31856736
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25190351
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15897444
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04062833
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.97540074
16SUZ12_27294783_Chip-Seq_NPCs_Mouse1.93007872
17NFE2_27457419_Chip-Seq_LIVER_Mouse1.88374184
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84964012
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83102294
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80218921
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79100409
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.78489186
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78222188
24EWS_26573619_Chip-Seq_HEK293_Human1.78084489
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72162795
26TAL1_26923725_Chip-Seq_HPCs_Mouse1.68818143
27P53_22387025_ChIP-Seq_ESCs_Mouse1.66742344
28FUS_26573619_Chip-Seq_HEK293_Human1.65111536
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64909653
30KDM2B_26808549_Chip-Seq_REH_Human1.59471514
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58511172
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58502808
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.56932939
34* P300_19829295_ChIP-Seq_ESCs_Human1.56718385
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56515970
36RNF2_27304074_Chip-Seq_NSC_Mouse1.55532142
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.52834795
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.50665827
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.50195311
40IRF1_19129219_ChIP-ChIP_H3396_Human1.48915096
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48371313
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.48121128
43SMAD4_21799915_ChIP-Seq_A2780_Human1.47268801
44AR_21572438_ChIP-Seq_LNCaP_Human1.45324506
45ER_23166858_ChIP-Seq_MCF-7_Human1.43593895
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43405066
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43405066
48P300_18555785_Chip-Seq_ESCs_Mouse1.43071654
49EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42977921
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42885794
51REST_21632747_ChIP-Seq_MESCs_Mouse1.41051199
52NMYC_18555785_Chip-Seq_ESCs_Mouse1.40265834
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.39731918
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39523382
55SOX2_18555785_Chip-Seq_ESCs_Mouse1.38845134
56SOX2_19829295_ChIP-Seq_ESCs_Human1.38747078
57NANOG_19829295_ChIP-Seq_ESCs_Human1.38747078
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.37788637
59* SMAD4_21741376_ChIP-Seq_EPCs_Human1.36239766
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.35889846
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34539084
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34398160
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34331276
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34023207
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31662775
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31656448
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30104681
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29656382
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28567892
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.28154372
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.26883417
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26883417
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.26530083
74* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26147201
75PU1_27457419_Chip-Seq_LIVER_Mouse1.25544416
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25429346
77TCF4_22108803_ChIP-Seq_LS180_Human1.25421734
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24539678
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24432892
80CBP_20019798_ChIP-Seq_JUKART_Human1.24432892
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23990578
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23522529
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23514442
84STAT1_17558387_ChIP-Seq_HELA_Human1.23038661
85TP53_22573176_ChIP-Seq_HFKS_Human1.22614513
86DROSHA_22980978_ChIP-Seq_HELA_Human1.22599011
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22216511
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.21517136
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.20824696
90SOX9_26525672_Chip-Seq_HEART_Mouse1.20669853
91AR_25329375_ChIP-Seq_VCAP_Human1.20429605
92ERA_21632823_ChIP-Seq_H3396_Human1.20378651
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18275412
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.17751862
95ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17517671
96BCAT_22108803_ChIP-Seq_LS180_Human1.16960945
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16596874
98ETV1_20927104_ChIP-Seq_GIST48_Human1.15907650
99SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15744270
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.14667546
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.14279487
102RBPJ_21746931_ChIP-Seq_IB4_Human1.13958228
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13665209
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.13401684
105MYC_19829295_ChIP-Seq_ESCs_Human1.12993122
106HOXB7_26014856_ChIP-Seq_BT474_Human1.12841557
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.12816733
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12192377
109NANOG_20526341_ChIP-Seq_ESCs_Human1.11836447
110TCF4_23295773_ChIP-Seq_U87_Human1.11261069
111IGF1R_20145208_ChIP-Seq_DFB_Human1.11002840
112NCOR_22424771_ChIP-Seq_293T_Human1.10950625
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10759806
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10224473
115* SMAD3_21741376_ChIP-Seq_ESCs_Human1.09817972
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09609997
117TAF2_19829295_ChIP-Seq_ESCs_Human1.08954617
118CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08835141
119GF1_26923725_Chip-Seq_HPCs_Mouse1.08677592
120TBL1_22424771_ChIP-Seq_293T_Human1.08456105
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07307943
122ZNF274_21170338_ChIP-Seq_K562_Hela1.06962461
123WDR5_24793694_ChIP-Seq_LNCAP_Human1.06892599
124FOXH1_21741376_ChIP-Seq_EPCs_Human1.06666577
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06408686
126AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05755494
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05611114
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04869503
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.04153812
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03017775
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02534821
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01026794
133NFYB_21822215_ChIP-Seq_K562_Human1.00332948
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99955988
135PHF8_20622853_ChIP-Seq_HELA_Human0.99868211
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98909602
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97458931
138* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97273600
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96923416
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94623340
141KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93895682
142STAT3_23295773_ChIP-Seq_U87_Human0.92991926
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91530861
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90902998
145RUNX2_22187159_ChIP-Seq_PCA_Human0.90881864
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.90156712
147SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89737779
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.89732771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.14806196
2MP0003698_abnormal_male_reproductive4.01531873
3MP0008877_abnormal_DNA_methylation3.86738025
4MP0001929_abnormal_gametogenesis3.60184342
5MP0000569_abnormal_digit_pigmentation2.84955594
6MP0004133_heterotaxia2.61829149
7MP0003011_delayed_dark_adaptation2.59751208
8MP0005646_abnormal_pituitary_gland2.54264334
9MP0003195_calcinosis2.50044987
10MP0010386_abnormal_urinary_bladder2.35286537
11MP0002210_abnormal_sex_determination2.25859816
12MP0005670_abnormal_white_adipose2.24669247
13MP0008872_abnormal_physiological_respon2.12019019
14MP0002736_abnormal_nociception_after2.09864129
15MP0000015_abnormal_ear_pigmentation2.03050453
16MP0002161_abnormal_fertility/fecundity2.03027065
17MP0003183_abnormal_peptide_metabolism2.01086143
18MP0005410_abnormal_fertilization10.5683338
19MP0001984_abnormal_olfaction1.94985258
20MP0002876_abnormal_thyroid_physiology1.92774923
21MP0005377_hearing/vestibular/ear_phenot1.92315391
22MP0003878_abnormal_ear_physiology1.92315391
23MP0009046_muscle_twitch1.89566171
24MP0001188_hyperpigmentation1.88621762
25MP0001145_abnormal_male_reproductive1.73613560
26MP0008875_abnormal_xenobiotic_pharmacok1.66482341
27MP0001986_abnormal_taste_sensitivity1.63541336
28MP0004885_abnormal_endolymph1.60578985
29MP0008058_abnormal_DNA_repair1.59707606
30MP0001485_abnormal_pinna_reflex1.59456670
31MP0003646_muscle_fatigue1.58643403
32MP0001968_abnormal_touch/_nociception1.54429472
33MP0000653_abnormal_sex_gland1.53701881
34MP0009697_abnormal_copulation1.50976073
35MP0006292_abnormal_olfactory_placode1.50156728
36MP0005171_absent_coat_pigmentation1.44039370
37MP0000427_abnormal_hair_cycle1.43177425
38MP0000049_abnormal_middle_ear1.42350278
39MP0002163_abnormal_gland_morphology1.38834619
40MP0003880_abnormal_central_pattern1.38618736
41MP0003121_genomic_imprinting1.38072420
42MP0006072_abnormal_retinal_apoptosis1.33013035
43MP0005167_abnormal_blood-brain_barrier1.32298499
44MP0002735_abnormal_chemical_nociception1.28826409
45MP0001970_abnormal_pain_threshold1.26381022
46MP0002822_catalepsy1.25816822
47MP0004142_abnormal_muscle_tone1.25310364
48MP0006276_abnormal_autonomic_nervous1.22156760
49MP0002733_abnormal_thermal_nociception1.21667586
50MP0005645_abnormal_hypothalamus_physiol1.18463694
51MP0002234_abnormal_pharynx_morphology1.18015892
52MP0002277_abnormal_respiratory_mucosa1.15008230
53MP0003119_abnormal_digestive_system1.14253050
54MP0005451_abnormal_body_composition1.13727626
55MP0009745_abnormal_behavioral_response1.13706196
56MP0000230_abnormal_systemic_arterial1.09767231
57MP0002734_abnormal_mechanical_nocicepti1.07558911
58MP0002572_abnormal_emotion/affect_behav1.07508028
59MP0000566_synostosis1.07294429
60MP0003136_yellow_coat_color1.06545264
61MP0002928_abnormal_bile_duct1.06242459
62MP0002837_dystrophic_cardiac_calcinosis1.06050514
63MP0004043_abnormal_pH_regulation1.05516592
64MP0005195_abnormal_posterior_eye1.03961835
65MP0005503_abnormal_tendon_morphology1.02124567
66MP0005085_abnormal_gallbladder_physiolo1.01947602
67MP0001835_abnormal_antigen_presentation1.01182191
68MP0002160_abnormal_reproductive_system0.98251773
69MP0004085_abnormal_heartbeat0.96735282
70MP0000778_abnormal_nervous_system0.95781148
71MP0005379_endocrine/exocrine_gland_phen0.94840275
72MP0003137_abnormal_impulse_conducting0.93180100
73MP0000678_abnormal_parathyroid_gland0.92533027
74MP0009780_abnormal_chondrocyte_physiolo0.91451852
75MP0008995_early_reproductive_senescence0.91044973
76MP0005174_abnormal_tail_pigmentation0.90190194
77MP0008007_abnormal_cellular_replicative0.89493592
78MP0004147_increased_porphyrin_level0.89296578
79MP0002067_abnormal_sensory_capabilities0.86040411
80MP0005075_abnormal_melanosome_morpholog0.85248720
81MP0001529_abnormal_vocalization0.85162219
82MP0002752_abnormal_somatic_nervous0.85152873
83MP0001324_abnormal_eye_pigmentation0.84248409
84MP0002063_abnormal_learning/memory/cond0.83942476
85MP0003718_maternal_effect0.83206752
86MP0002272_abnormal_nervous_system0.83193659
87MP0001440_abnormal_grooming_behavior0.83190314
88MP0002229_neurodegeneration0.83176352
89MP0008789_abnormal_olfactory_epithelium0.82949768
90MP0001486_abnormal_startle_reflex0.82428852
91MP0008004_abnormal_stomach_pH0.81463081
92MP0004782_abnormal_surfactant_physiolog0.81366435
93MP0002064_seizures0.81045586
94MP0002653_abnormal_ependyma_morphology0.80442295
95MP0000955_abnormal_spinal_cord0.79976738
96MP0005389_reproductive_system_phenotype0.79672145
97MP0002148_abnormal_hypersensitivity_rea0.78830450
98MP0005253_abnormal_eye_physiology0.78477866
99MP0004859_abnormal_synaptic_plasticity0.78358569
100MP0002638_abnormal_pupillary_reflex0.78084535
101MP0002882_abnormal_neuron_morphology0.77565269
102MP0004215_abnormal_myocardial_fiber0.76925631
103MP0003635_abnormal_synaptic_transmissio0.76392051
104MP0000372_irregular_coat_pigmentation0.75032982
105MP0001963_abnormal_hearing_physiology0.74417572
106MP0003879_abnormal_hair_cell0.73545632
107MP0001501_abnormal_sleep_pattern0.71380423
108MP0000631_abnormal_neuroendocrine_gland0.70590005
109MP0002102_abnormal_ear_morphology0.69901255
110MP0000026_abnormal_inner_ear0.69237003
111MP0001502_abnormal_circadian_rhythm0.68421727
112MP0002095_abnormal_skin_pigmentation0.68075486
113MP0008569_lethality_at_weaning0.67968924
114MP0000681_abnormal_thyroid_gland0.67856210
115MP0001119_abnormal_female_reproductive0.67350464
116MP0004742_abnormal_vestibular_system0.66809255
117MP0002557_abnormal_social/conspecific_i0.64548521
118MP0002132_abnormal_respiratory_system0.64270605
119MP0005084_abnormal_gallbladder_morpholo0.64262719
120MP0001764_abnormal_homeostasis0.64116928
121MP0001177_atelectasis0.62917925
122MP0005551_abnormal_eye_electrophysiolog0.62818233
123MP0005647_abnormal_sex_gland0.62469048
124MP0003943_abnormal_hepatobiliary_system0.55294990
125MP0003724_increased_susceptibility_to0.55225387
126MP0001919_abnormal_reproductive_system0.54890757
127MP0003123_paternal_imprinting0.54254018
128MP0009764_decreased_sensitivity_to0.54249496
129MP0010094_abnormal_chromosome_stability0.53025631
130MP0009785_altered_susceptibility_to0.52736721
131MP0008260_abnormal_autophagy0.52656615
132MP0002108_abnormal_muscle_morphology0.51401892
133MP0005423_abnormal_somatic_nervous0.51172026
134MP0002419_abnormal_innate_immunity0.51038459
135MP0001765_abnormal_ion_homeostasis0.50823218
136MP0002127_abnormal_cardiovascular_syste0.49035011
137MP0003122_maternal_imprinting0.48238942
138MP0005671_abnormal_response_to0.48068116
139MP0005257_abnormal_intraocular_pressure0.45767502
140MP0001905_abnormal_dopamine_level0.45736698
141MP0002282_abnormal_trachea_morphology0.45567216

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.61885341
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.61885341
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.96240990
4Abnormal respiratory epithelium morphology (HP:0012253)6.74431559
5Abnormal respiratory motile cilium morphology (HP:0005938)6.74431559
6Abnormal respiratory motile cilium physiology (HP:0012261)6.45212491
7Abnormal ciliary motility (HP:0012262)5.37692617
8Rhinitis (HP:0012384)4.86980718
9Infertility (HP:0000789)4.66753670
10Chronic bronchitis (HP:0004469)4.25922961
11Type II lissencephaly (HP:0007260)4.10577527
12Medial flaring of the eyebrow (HP:0010747)3.68190455
13Nephronophthisis (HP:0000090)3.64227899
14Congenital stationary night blindness (HP:0007642)3.58379494
15Attenuation of retinal blood vessels (HP:0007843)3.49832221
16Abnormal spermatogenesis (HP:0008669)3.43103164
17Birth length less than 3rd percentile (HP:0003561)3.24874642
18Tubulointerstitial nephritis (HP:0001970)3.18201693
19Nasal polyposis (HP:0100582)3.15058054
20Abnormality of the renal medulla (HP:0100957)2.97831610
21Retinal dysplasia (HP:0007973)2.95871448
22Bronchiectasis (HP:0002110)2.82875769
23Bronchitis (HP:0012387)2.79363965
24Nephrogenic diabetes insipidus (HP:0009806)2.75913619
25Abnormal hair whorl (HP:0010721)2.74964154
26Congenital primary aphakia (HP:0007707)2.68015897
27Bony spicule pigmentary retinopathy (HP:0007737)2.62808963
28Gait imbalance (HP:0002141)2.61885842
29Abnormal rod and cone electroretinograms (HP:0008323)2.61837508
30Lissencephaly (HP:0001339)2.60879079
31Abolished electroretinogram (ERG) (HP:0000550)2.60672196
32Epileptic encephalopathy (HP:0200134)2.58186411
33Pancreatic fibrosis (HP:0100732)2.57979747
34Sclerocornea (HP:0000647)2.56476011
35Hyperventilation (HP:0002883)2.55555667
36Azoospermia (HP:0000027)2.55402773
37Inability to walk (HP:0002540)2.54317307
38Large for gestational age (HP:0001520)2.52485085
39Male infertility (HP:0003251)2.52217506
40Cystic liver disease (HP:0006706)2.52174825
41Thyroid-stimulating hormone excess (HP:0002925)2.51574364
42Abnormality of macular pigmentation (HP:0008002)2.51212074
43Abnormality of midbrain morphology (HP:0002418)2.50576379
44Molar tooth sign on MRI (HP:0002419)2.50576379
45Recurrent sinusitis (HP:0011108)2.50465474
46Congenital, generalized hypertrichosis (HP:0004540)2.47991729
47Decreased central vision (HP:0007663)2.47892608
48Pendular nystagmus (HP:0012043)2.47137914
49Febrile seizures (HP:0002373)2.45371633
50Optic nerve hypoplasia (HP:0000609)2.45253689
51Chorioretinal atrophy (HP:0000533)2.40313425
52Postaxial foot polydactyly (HP:0001830)2.37811740
53Type 2 muscle fiber atrophy (HP:0003554)2.36817698
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.36804882
55Cerebellar dysplasia (HP:0007033)2.34040430
56True hermaphroditism (HP:0010459)2.33551980
57Dyschromatopsia (HP:0007641)2.32634010
58Polyuria (HP:0000103)2.31880221
59Progressive inability to walk (HP:0002505)2.31218830
60Progressive cerebellar ataxia (HP:0002073)2.27105294
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23450593
62Increased corneal curvature (HP:0100692)2.21367774
63Keratoconus (HP:0000563)2.21367774
64Poor coordination (HP:0002370)2.21177515
65Aplasia/Hypoplasia of the lens (HP:0008063)2.21077805
66Tubular atrophy (HP:0000092)2.21036526
67Abnormality of the nasal mucosa (HP:0000433)2.20391384
68Anencephaly (HP:0002323)2.17991383
69Chronic hepatic failure (HP:0100626)2.12506423
70Bile duct proliferation (HP:0001408)2.08193825
71Abnormal biliary tract physiology (HP:0012439)2.08193825
72Tubulointerstitial abnormality (HP:0001969)2.05846976
73Male pseudohermaphroditism (HP:0000037)2.05146274
74Furrowed tongue (HP:0000221)2.03243456
75Congenital hepatic fibrosis (HP:0002612)2.02939132
76Abnormality of the labia minora (HP:0012880)2.01124655
77Abnormal urine output (HP:0012590)2.00879356
78Gastrointestinal atresia (HP:0002589)2.00431597
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00420218
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99624059
81Stomach cancer (HP:0012126)1.99307774
82Abnormality of the renal cortex (HP:0011035)1.99027552
83Cone-rod dystrophy (HP:0000548)1.98909829
84Recurrent otitis media (HP:0000403)1.98623209
85Retrobulbar optic neuritis (HP:0100654)1.98289165
86Optic neuritis (HP:0100653)1.98289165
87Genital tract atresia (HP:0001827)1.97743185
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97480736
89Abnormality of alanine metabolism (HP:0010916)1.97480736
90Hyperalaninemia (HP:0003348)1.97480736
91Renal cortical cysts (HP:0000803)1.97329770
92Hypoplasia of the fovea (HP:0007750)1.96296778
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.96296778
94Aplasia/hypoplasia of the uterus (HP:0008684)1.95096014
95Focal motor seizures (HP:0011153)1.94448454
96Severe visual impairment (HP:0001141)1.90782099
97Postaxial hand polydactyly (HP:0001162)1.90614234
98Conical tooth (HP:0000698)1.90296245
99Hypoplasia of the uterus (HP:0000013)1.89881344
100Decreased circulating renin level (HP:0003351)1.89836644
101Amelogenesis imperfecta (HP:0000705)1.89827537
102Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.89220153
103Alveolar cell carcinoma (HP:0006519)1.88985939
104Bilateral microphthalmos (HP:0007633)1.88691793
105Chromsome breakage (HP:0040012)1.88292232
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.87714685
107Short tibia (HP:0005736)1.86977484
108Median cleft lip (HP:0000161)1.86858884
109Patellar aplasia (HP:0006443)1.86032624
110Nephroblastoma (Wilms tumor) (HP:0002667)1.86021299
111Abnormality of the renal collecting system (HP:0004742)1.85103111
112Vaginal atresia (HP:0000148)1.83987322
113Hypothermia (HP:0002045)1.83478381
114Myokymia (HP:0002411)1.82786843
115Embryonal renal neoplasm (HP:0011794)1.82604566
116Recurrent bronchitis (HP:0002837)1.81657968
117Abnormality of incisor morphology (HP:0011063)1.79717924
118Aplasia/Hypoplasia of the patella (HP:0006498)1.79693784
119Abnormality of the pubic bones (HP:0003172)1.76930375
120Preaxial hand polydactyly (HP:0001177)1.76679161
121Anophthalmia (HP:0000528)1.75689736
122Renal dysplasia (HP:0000110)1.75210384
123Abnormality of renal excretion (HP:0011036)1.74678644
124Constricted visual fields (HP:0001133)1.74678324
125Choroideremia (HP:0001139)1.74671124
126Abnormal drinking behavior (HP:0030082)1.74229122
127Polydipsia (HP:0001959)1.74229122
128Short femoral neck (HP:0100864)1.73805281
129Esophageal atresia (HP:0002032)1.73573539
130Fair hair (HP:0002286)1.72676070
131Impulsivity (HP:0100710)1.72553942
132Aplasia/Hypoplasia of the macula (HP:0008059)1.71568816
133Hypomagnesemia (HP:0002917)1.70480544
134Bell-shaped thorax (HP:0001591)1.70381175
135Pancreatic cysts (HP:0001737)1.70105934
136Duplicated collecting system (HP:0000081)1.69122571
137Generalized hypopigmentation of hair (HP:0011358)1.69096323
138Muscle fiber atrophy (HP:0100295)1.68275080
139Type I transferrin isoform profile (HP:0003642)1.67832088
140Pachygyria (HP:0001302)1.67154957
141Widely spaced teeth (HP:0000687)1.66944916
142Atonic seizures (HP:0010819)1.66088409
143Abnormality of the fovea (HP:0000493)1.65782317
144Protruding tongue (HP:0010808)1.65718611
145Facial cleft (HP:0002006)1.64553247
146Chronic sinusitis (HP:0011109)1.64474024
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63099313
148Stage 5 chronic kidney disease (HP:0003774)1.62123718
149Fibular hypoplasia (HP:0003038)1.61286623
150Astigmatism (HP:0000483)1.60845586
151Nephropathy (HP:0000112)1.60560352
152Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.60199852
153Occipital encephalocele (HP:0002085)1.58935957
154Long foot (HP:0001833)1.55467701
155Fetal akinesia sequence (HP:0001989)1.55037615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.06449094
2PDK35.02931609
3PDK45.02931609
4FRK3.87670853
5PDK23.72913091
6ACVR1B3.65308848
7PRKD33.38532562
8TLK13.17823859
9TESK13.08064330
10MAP2K72.62649649
11MAP4K22.60428137
12STK38L2.40516750
13ICK2.25801531
14ZAK2.17329564
15AKT32.16892859
16PRPF4B2.13257010
17BMPR1B1.77352885
18TXK1.76302107
19TAOK31.75875843
20MAP3K121.73146537
21MAP3K141.72550636
22CCNB11.65663555
23SIK31.62056993
24DAPK21.59362800
25MYLK1.55001461
26MARK11.51922171
27ADRBK21.51510474
28YES11.48800603
29SGK21.48680863
30FGFR21.45181048
31TGFBR11.35369825
32EIF2AK21.29758990
33BMPR21.25649894
34PNCK1.22161060
35STK381.21563351
36CAMKK21.13012706
37PLK21.11764722
38OXSR11.11607614
39ERBB31.09853512
40MAP3K41.09625611
41PTK2B1.08568222
42MAPK131.07210683
43TSSK61.05818874
44PINK11.03389494
45CDK31.03335456
46PLK40.97095302
47CAMK1D0.95687438
48MUSK0.95421201
49MAPKAPK30.94967322
50DYRK20.94946266
51PAK30.93035653
52CDK80.91153366
53IRAK40.88587798
54CAMK1G0.88458468
55TAF10.87181988
56STK240.85591045
57NME10.84900404
58SIK20.84118172
59TNIK0.84043573
60NEK10.83513057
61BRD40.82649001
62PHKG20.82150424
63PHKG10.82150424
64GRK70.81506542
65NEK60.81025061
66SGK2230.79841856
67SGK4940.79841856
68WNK40.76754429
69INSRR0.75907672
70LIMK10.75827470
71TNK20.75164661
72IRAK30.74618075
73RIPK40.73655808
74TRIM280.73010467
75NEK20.70947816
76NTRK30.70651222
77RPS6KB10.70390273
78EIF2AK10.69751236
79MKNK20.69685348
80SGK30.68762581
81WNK30.68629003
82STK160.65984067
83PRKCG0.64593367
84EPHA40.63922863
85IRAK10.62672085
86NUAK10.60379131
87TIE10.58921141
88CSNK1G20.58763059
89CAMK10.57976171
90MST40.56550766
91PRKCE0.55248114
92VRK20.53265171
93PASK0.52886924
94CSNK1G30.52665749
95CHEK20.51316025
96VRK10.50941750
97MAP2K10.48862866
98PDK10.48540494
99NTRK20.47488895
100ATR0.46795143
101PRKACA0.46029354
102CLK10.43696653
103STK30.41941133
104KIT0.41523561
105STK390.41350003
106PRKCD0.40458365
107PRKCZ0.40120285
108EIF2AK30.39418607
109DAPK10.39273466
110IKBKB0.38745721
111CAMK2A0.38291273
112PRKAA20.37705651
113CSNK1G10.37091908
114CSNK1A1L0.36979330
115MAPK150.36690796
116STK110.36235259
117TEC0.36181603
118PRKCQ0.35895761
119MKNK10.34879671
120SGK10.34758417
121CSNK1D0.34688146
122WNK10.32590708
123MAP2K60.32355564
124BRSK20.32307081
125MAPKAPK50.32291379
126BRAF0.32265552
127GRK10.31632585
128PRKG20.30943358
129PLK30.30941846
130ATM0.30431123
131CAMKK10.30332631
132PIK3CG0.29468062
133CSF1R0.29284731
134FGFR10.29192699
135BCR0.29064902
136CSNK1A10.29023995
137PRKG10.28606179
138MAPK70.28295991
139ERBB40.27352153
140IRAK20.26663478
141PKN10.26528927
142CHUK0.26500554
143PLK10.26489075
144PRKAA10.26183707
145ADRBK10.25866715
146TTK0.25791165
147PIM10.25744216
148FER0.25199129
149TAOK20.25159270
150CAMK40.25140156
151PRKCA0.24801035
152BLK0.24506629
153PRKCH0.24021275

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.44135666
2Collecting duct acid secretion_Homo sapiens_hsa049663.10015715
3Butanoate metabolism_Homo sapiens_hsa006503.05363236
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.79515060
5Nicotine addiction_Homo sapiens_hsa050332.74438095
6Fanconi anemia pathway_Homo sapiens_hsa034602.55235554
7Fatty acid biosynthesis_Homo sapiens_hsa000612.36407679
8Nitrogen metabolism_Homo sapiens_hsa009102.34385263
9Rheumatoid arthritis_Homo sapiens_hsa053232.34090170
10Tryptophan metabolism_Homo sapiens_hsa003802.28067872
11Basal transcription factors_Homo sapiens_hsa030222.26331204
12Synaptic vesicle cycle_Homo sapiens_hsa047212.21215929
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08361276
14Type I diabetes mellitus_Homo sapiens_hsa049402.03143881
15Selenocompound metabolism_Homo sapiens_hsa004502.00989741
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99412836
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95930681
18Caffeine metabolism_Homo sapiens_hsa002321.92461542
19Taste transduction_Homo sapiens_hsa047421.91948253
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.83143761
21Morphine addiction_Homo sapiens_hsa050321.78101846
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76139069
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74183894
24Legionellosis_Homo sapiens_hsa051341.72163722
25Graft-versus-host disease_Homo sapiens_hsa053321.70891353
26Autoimmune thyroid disease_Homo sapiens_hsa053201.69960719
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69057579
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69025296
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.67194913
30Allograft rejection_Homo sapiens_hsa053301.66696472
31Linoleic acid metabolism_Homo sapiens_hsa005911.62663153
32Purine metabolism_Homo sapiens_hsa002301.60626176
33ABC transporters_Homo sapiens_hsa020101.56287735
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50983993
35Olfactory transduction_Homo sapiens_hsa047401.49158169
36Arachidonic acid metabolism_Homo sapiens_hsa005901.47118997
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44193460
38Phagosome_Homo sapiens_hsa041451.39357576
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.37121420
40Amphetamine addiction_Homo sapiens_hsa050311.36353529
41Insulin secretion_Homo sapiens_hsa049111.34463789
42Vibrio cholerae infection_Homo sapiens_hsa051101.31852224
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.30133421
44Renin secretion_Homo sapiens_hsa049241.29527947
45Non-homologous end-joining_Homo sapiens_hsa034501.29457713
46Vitamin B6 metabolism_Homo sapiens_hsa007501.26445052
47Pyruvate metabolism_Homo sapiens_hsa006201.25873239
48Histidine metabolism_Homo sapiens_hsa003401.24725967
49Base excision repair_Homo sapiens_hsa034101.24147217
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22916899
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22471157
52Peroxisome_Homo sapiens_hsa041461.22364298
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21755740
54Calcium signaling pathway_Homo sapiens_hsa040201.18165089
55Fat digestion and absorption_Homo sapiens_hsa049751.17938885
56Parkinsons disease_Homo sapiens_hsa050121.15029310
57Circadian entrainment_Homo sapiens_hsa047131.11639104
58Chemical carcinogenesis_Homo sapiens_hsa052041.11612242
59Cardiac muscle contraction_Homo sapiens_hsa042601.11109115
60beta-Alanine metabolism_Homo sapiens_hsa004101.09584807
61Glucagon signaling pathway_Homo sapiens_hsa049221.09480805
62Fatty acid degradation_Homo sapiens_hsa000711.04428175
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04306882
64Serotonergic synapse_Homo sapiens_hsa047261.02932290
65Retinol metabolism_Homo sapiens_hsa008300.99281967
66Ether lipid metabolism_Homo sapiens_hsa005650.99019560
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96742837
68Fructose and mannose metabolism_Homo sapiens_hsa000510.95142481
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94710812
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94591263
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92652390
72Sulfur metabolism_Homo sapiens_hsa009200.88999069
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88779931
74Measles_Homo sapiens_hsa051620.88381904
75Arginine and proline metabolism_Homo sapiens_hsa003300.86662214
76Propanoate metabolism_Homo sapiens_hsa006400.85387616
77Other glycan degradation_Homo sapiens_hsa005110.83182006
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.81793342
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77258711
80Homologous recombination_Homo sapiens_hsa034400.74892682
81Ovarian steroidogenesis_Homo sapiens_hsa049130.72919845
82Antigen processing and presentation_Homo sapiens_hsa046120.72908062
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.72832784
84Huntingtons disease_Homo sapiens_hsa050160.72648684
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71563939
86Fatty acid metabolism_Homo sapiens_hsa012120.71440692
87GABAergic synapse_Homo sapiens_hsa047270.70893449
88Phototransduction_Homo sapiens_hsa047440.70440824
89Mineral absorption_Homo sapiens_hsa049780.69885040
90Alzheimers disease_Homo sapiens_hsa050100.69411335
91Cocaine addiction_Homo sapiens_hsa050300.68374446
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67917963
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67914967
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.66918466
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66167371
96Glutamatergic synapse_Homo sapiens_hsa047240.65483418
97Salivary secretion_Homo sapiens_hsa049700.65446392
98Circadian rhythm_Homo sapiens_hsa047100.65114749
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64357681
100Protein export_Homo sapiens_hsa030600.63823872
101cAMP signaling pathway_Homo sapiens_hsa040240.63818333
102Inositol phosphate metabolism_Homo sapiens_hsa005620.63556548
103Sphingolipid metabolism_Homo sapiens_hsa006000.63112222
104Oxidative phosphorylation_Homo sapiens_hsa001900.62495288
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61776714
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61399521
107RNA degradation_Homo sapiens_hsa030180.60109917
108Pyrimidine metabolism_Homo sapiens_hsa002400.58418912
109Long-term potentiation_Homo sapiens_hsa047200.58413465
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57740034
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.57002490
112RNA polymerase_Homo sapiens_hsa030200.56783152
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53679180
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.53675515
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50401195
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.50227327
117Influenza A_Homo sapiens_hsa051640.49282108
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48642434
119Proteasome_Homo sapiens_hsa030500.48585751
120Salmonella infection_Homo sapiens_hsa051320.46639377
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46615088
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46072827
123mRNA surveillance pathway_Homo sapiens_hsa030150.45832969
124Hedgehog signaling pathway_Homo sapiens_hsa043400.43910967
125Dorso-ventral axis formation_Homo sapiens_hsa043200.41723883
126Tuberculosis_Homo sapiens_hsa051520.41202858
127Long-term depression_Homo sapiens_hsa047300.41161109
128African trypanosomiasis_Homo sapiens_hsa051430.41083123
129Primary immunodeficiency_Homo sapiens_hsa053400.40925053
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40397057
131N-Glycan biosynthesis_Homo sapiens_hsa005100.38320782
132Asthma_Homo sapiens_hsa053100.36762311
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35859091
134Type II diabetes mellitus_Homo sapiens_hsa049300.35842489
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35598534
136Vitamin digestion and absorption_Homo sapiens_hsa049770.34532374
137Regulation of autophagy_Homo sapiens_hsa041400.34438216
138Metabolic pathways_Homo sapiens_hsa011000.34353799
139Hematopoietic cell lineage_Homo sapiens_hsa046400.34133265
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33919031
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33820783
142Cholinergic synapse_Homo sapiens_hsa047250.33316197
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33047387
144Malaria_Homo sapiens_hsa051440.33006085
145Tyrosine metabolism_Homo sapiens_hsa003500.30680763
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30658797
147Herpes simplex infection_Homo sapiens_hsa051680.30154185
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30024276
149Dopaminergic synapse_Homo sapiens_hsa047280.28608443
150Glycerolipid metabolism_Homo sapiens_hsa005610.28031480
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26886037

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