PRSS51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.90700956
2binding of sperm to zona pellucida (GO:0007339)9.53459182
3spermatid development (GO:0007286)9.42741889
4cell-cell recognition (GO:0009988)9.28882384
5multicellular organism reproduction (GO:0032504)9.02255395
6plasma membrane fusion (GO:0045026)8.72931269
7regulation of cilium movement (GO:0003352)8.71451021
8reproduction (GO:0000003)8.16435023
9motile cilium assembly (GO:0044458)8.06968152
10epithelial cilium movement (GO:0003351)7.99140021
11negative regulation of inclusion body assembly (GO:0090084)7.74602428
12axonemal dynein complex assembly (GO:0070286)7.72285289
13sperm capacitation (GO:0048240)6.56379672
14organic cation transport (GO:0015695)6.31904904
15synaptonemal complex organization (GO:0070193)6.31702167
16synaptonemal complex assembly (GO:0007130)6.29395993
17cilium movement (GO:0003341)6.24226842
18regulation of inclusion body assembly (GO:0090083)6.24089192
19spermatogenesis (GO:0007283)6.19629914
20single fertilization (GO:0007338)6.19497033
21male gamete generation (GO:0048232)6.16674350
22ventricular system development (GO:0021591)5.78791916
23gamete generation (GO:0007276)5.64279454
24calcium ion-dependent exocytosis (GO:0017156)5.57300710
25chromosome condensation (GO:0030261)5.52574001
26microtubule depolymerization (GO:0007019)5.49858696
27male meiosis (GO:0007140)5.44402721
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.38081271
29protein targeting to Golgi (GO:0000042)5.34826915
30establishment of protein localization to Golgi (GO:0072600)5.25392182
31cilium or flagellum-dependent cell motility (GO:0001539)5.24656491
32fertilization (GO:0009566)5.24036068
33spermatid nucleus differentiation (GO:0007289)5.23237386
34DNA packaging (GO:0006323)5.20738503
35sexual reproduction (GO:0019953)5.16063720
36chaperone-mediated protein complex assembly (GO:0051131)5.15189710
37mature B cell differentiation involved in immune response (GO:0002313)5.11514522
38germ cell development (GO:0007281)5.02427359
39retrograde transport, vesicle recycling within Golgi (GO:0000301)5.00436819
40regulation of microtubule-based movement (GO:0060632)4.93183757
41piRNA metabolic process (GO:0034587)4.92543555
42negative regulation of DNA-templated transcription, elongation (GO:0032785)4.81233503
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.81233503
44protein polyglutamylation (GO:0018095)4.80821442
45glycerol ether metabolic process (GO:0006662)4.70192387
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.68806698
47cell recognition (GO:0008037)4.63741431
48phosphatidylethanolamine biosynthetic process (GO:0006646)4.59614860
49multicellular organismal reproductive process (GO:0048609)4.44344882
50ether metabolic process (GO:0018904)4.31392286
51phosphatidylethanolamine metabolic process (GO:0046337)4.26797974
52centriole replication (GO:0007099)4.24968321
53chromosome organization involved in meiosis (GO:0070192)4.20486408
54microtubule severing (GO:0051013)4.15623787
55positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.14873573
56regulation of phosphoprotein phosphatase activity (GO:0043666)4.11336608
57centriole assembly (GO:0098534)4.08395670
58single strand break repair (GO:0000012)3.90506159
59regulation of Rab GTPase activity (GO:0032313)3.87793361
60positive regulation of Rab GTPase activity (GO:0032851)3.87793361
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79876511
62multicellular organismal development (GO:0007275)3.74225513
63protein localization to Golgi apparatus (GO:0034067)3.73650152
64mitochondrion degradation (GO:0000422)3.71187821
65male meiosis I (GO:0007141)3.71170052
66positive regulation of CREB transcription factor activity (GO:0032793)3.63431389
67mature B cell differentiation (GO:0002335)3.62767283
68left/right pattern formation (GO:0060972)3.62303018
69response to pheromone (GO:0019236)3.61610251
70cellular response to arsenic-containing substance (GO:0071243)3.61451222
71chromatin silencing (GO:0006342)3.61276297
72polyol catabolic process (GO:0046174)3.60165674
73glutamate secretion (GO:0014047)3.53293008
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51339338
75neuronal ion channel clustering (GO:0045161)3.48159980
76protein K11-linked deubiquitination (GO:0035871)3.46653220
77synaptic vesicle exocytosis (GO:0016079)3.45258988
78rRNA methylation (GO:0031167)3.39886625
79sequestering of actin monomers (GO:0042989)3.37955530
80seminiferous tubule development (GO:0072520)3.37417280
81neurotransmitter-gated ion channel clustering (GO:0072578)3.37118485
82protein localization to cilium (GO:0061512)3.36422164
83regulation of synaptic vesicle transport (GO:1902803)3.36322449
84locomotory exploration behavior (GO:0035641)3.34821620
85membrane depolarization during action potential (GO:0086010)3.32602026
86ionotropic glutamate receptor signaling pathway (GO:0035235)3.32000042
87L-amino acid import (GO:0043092)3.29862584
88protein refolding (GO:0042026)3.28549350
89glomerular visceral epithelial cell development (GO:0072015)3.24200511
90embryonic skeletal joint morphogenesis (GO:0060272)3.21823706
91regulation of ARF GTPase activity (GO:0032312)3.20654821
92positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.20091766
93purine nucleotide salvage (GO:0032261)3.17148262
94response to acidic pH (GO:0010447)3.15556379
95synaptic vesicle maturation (GO:0016188)3.13243025
96negative regulation of interleukin-8 production (GO:0032717)3.10442318
97positive regulation of macrophage activation (GO:0043032)3.09309492
98microtubule nucleation (GO:0007020)3.08999245
99positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.08905943
100RNA destabilization (GO:0050779)3.06795239
101synaptic vesicle docking involved in exocytosis (GO:0016081)3.06065485
102carnitine transport (GO:0015879)3.00860910
103amino-acid betaine transport (GO:0015838)3.00860910
104meiotic nuclear division (GO:0007126)2.99885045
105coenzyme catabolic process (GO:0009109)2.98568538
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97918182
107Peyers patch development (GO:0048541)2.97140594
108mucosal-associated lymphoid tissue development (GO:0048537)2.97140594
109regulation of synaptic vesicle exocytosis (GO:2000300)2.96576791
110regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96331608
111positive regulation of synapse maturation (GO:0090129)2.95947887
112glutamate receptor signaling pathway (GO:0007215)2.95209764
113glomerular epithelial cell development (GO:0072310)2.91386836
114meiosis I (GO:0007127)2.86552767
115DNA methylation involved in gamete generation (GO:0043046)2.86115133
116carnitine transmembrane transport (GO:1902603)2.84197875
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83795547
118positive regulation of cell cycle G1/S phase transition (GO:1902808)2.83655586
119regulation of cilium assembly (GO:1902017)2.82155156
120regulation of centriole replication (GO:0046599)2.82080551
121vesicle transport along microtubule (GO:0047496)2.80514821
122nucleus organization (GO:0006997)2.78700920
123glycolytic process (GO:0006096)2.75224446
124regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.73451846
125polyamine biosynthetic process (GO:0006596)2.72935408
126receptor recycling (GO:0001881)2.72919387
127presynaptic membrane assembly (GO:0097105)2.71421961
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71414551
129multicellular organismal movement (GO:0050879)2.70725082
130musculoskeletal movement (GO:0050881)2.70725082
131regulation of acrosome reaction (GO:0060046)2.69836602
132regulation of synapse maturation (GO:0090128)2.69389263
133regulation of transcription involved in cell fate commitment (GO:0060850)2.69236277
134negative regulation of dendrite morphogenesis (GO:0050774)2.67981233
135dorsal/ventral axis specification (GO:0009950)2.66499151
136chaperone mediated protein folding requiring cofactor (GO:0051085)2.66456787
137long-term memory (GO:0007616)2.66152107
138microtubule polymerization or depolymerization (GO:0031109)2.65886793
139ectodermal placode formation (GO:0060788)2.65726301
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65718770
141retinal cone cell development (GO:0046549)2.64860934
142urinary tract smooth muscle contraction (GO:0014848)2.63769493
143relaxation of smooth muscle (GO:0044557)2.63757492
144energy homeostasis (GO:0097009)2.63473822
145positive regulation of catecholamine secretion (GO:0033605)2.61869611
146lipid translocation (GO:0034204)2.60922464
147phospholipid translocation (GO:0045332)2.60922464
148centrosome duplication (GO:0051298)2.58935557
149cellular ketone body metabolic process (GO:0046950)2.58569222
150oocyte development (GO:0048599)2.58111826
151alditol metabolic process (GO:0019400)2.58074754
152calcium ion import (GO:0070509)2.57328689
153exploration behavior (GO:0035640)2.57198333
154histone H3-K9 demethylation (GO:0033169)2.55011746
155sperm motility (GO:0030317)13.3547251
156cell wall macromolecule catabolic process (GO:0016998)12.6350227
157cell wall macromolecule metabolic process (GO:0044036)12.6350227
158acrosome reaction (GO:0007340)11.9184567
159fusion of sperm to egg plasma membrane (GO:0007342)10.5378439
160sperm-egg recognition (GO:0035036)10.3546319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.02223716
2EZH2_22144423_ChIP-Seq_EOC_Human4.75323458
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.43202614
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.07691857
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.36668696
6GBX2_23144817_ChIP-Seq_PC3_Human3.17639164
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87120027
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71749925
9VDR_22108803_ChIP-Seq_LS180_Human2.69342546
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52355278
11DROSHA_22980978_ChIP-Seq_HELA_Human2.51678224
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.34247073
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24296531
14AR_21572438_ChIP-Seq_LNCaP_Human2.07733535
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.05485765
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02152033
17ARNT_22903824_ChIP-Seq_MCF-7_Human1.99693390
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95973593
19TAF15_26573619_Chip-Seq_HEK293_Human1.82427140
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.80032436
21SMAD4_21799915_ChIP-Seq_A2780_Human1.77335320
22SCL_19346495_ChIP-Seq_HPC-7_Human1.76223520
23AHR_22903824_ChIP-Seq_MCF-7_Human1.76070449
24MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75508225
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71731220
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69596172
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67845611
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67845611
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64928802
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62074078
31GATA3_21867929_ChIP-Seq_CD8_Mouse1.60780177
32STAT3_23295773_ChIP-Seq_U87_Human1.60566023
33IGF1R_20145208_ChIP-Seq_DFB_Human1.59796345
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59612065
35P300_19829295_ChIP-Seq_ESCs_Human1.58155958
36STAT1_17558387_ChIP-Seq_HELA_Human1.56478051
37ER_23166858_ChIP-Seq_MCF-7_Human1.55025480
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54952941
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.54783551
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54658668
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.53865079
42AR_25329375_ChIP-Seq_VCAP_Human1.53772964
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51589652
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.51325813
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51223547
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.48689884
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48670426
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48146844
49FUS_26573619_Chip-Seq_HEK293_Human1.47283998
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46602358
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.45629968
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.44510665
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.44190602
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43061003
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42025620
56CBP_20019798_ChIP-Seq_JUKART_Human1.41738045
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41738045
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40051081
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.40024783
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39096390
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.38990564
62REST_21632747_ChIP-Seq_MESCs_Mouse1.38961707
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38487708
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38324450
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37967666
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36158645
67RUNX2_22187159_ChIP-Seq_PCA_Human1.35995012
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34789821
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34496869
70P53_21459846_ChIP-Seq_SAOS-2_Human1.33865226
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33606550
72TCF4_23295773_ChIP-Seq_U87_Human1.32623195
73MYC_27129775_Chip-Seq_CORNEA_Mouse1.31864117
74TBL1_22424771_ChIP-Seq_293T_Human1.31849636
75KDM2B_26808549_Chip-Seq_REH_Human1.31289617
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30217936
77RXR_22108803_ChIP-Seq_LS180_Human1.28927060
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27726818
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27163439
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26751432
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26224684
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25682700
83GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.25658346
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24784593
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23950056
86TP53_18474530_ChIP-ChIP_U2OS_Human1.22732282
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22607148
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.22600331
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.22075179
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20440407
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19543642
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19341408
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19297679
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.19257686
95SMAD3_21741376_ChIP-Seq_ESCs_Human1.18556961
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16879888
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16853761
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16320060
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.16208884
100GATA3_21867929_ChIP-Seq_TH1_Mouse1.15715438
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14620944
102CTCF_20526341_ChIP-Seq_ESCs_Human1.14492554
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.14470573
104AR_19668381_ChIP-Seq_PC3_Human1.14254528
105SPI1_26923725_Chip-Seq_HPCs_Mouse1.13945866
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13256329
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11861742
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11571988
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11462752
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.10825611
111FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09388217
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.07880758
113ERG_20517297_ChIP-Seq_VCAP_Human1.07241561
114RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06878363
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06878363
116NFYB_21822215_ChIP-Seq_K562_Human1.04765722
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04678034
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.04579186
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04116475
120MYC_19829295_ChIP-Seq_ESCs_Human1.03942442
121ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02988218
122OCT1_27270436_Chip-Seq_PROSTATE_Human1.01951064
123LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01591804
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.01436105
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.01425094
126BCOR_27268052_Chip-Seq_Bcells_Human1.01338739
127LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00768746
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00528325
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00244890
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.99992432
131BCL6_27268052_Chip-Seq_Bcells_Human0.99367570
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99082774
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98762537
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98183210
135ERA_21632823_ChIP-Seq_H3396_Human0.97632025
136RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96926131
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96735549
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96542518
139VDR_24787735_ChIP-Seq_THP-1_Human0.96518840
140FLI1_21867929_ChIP-Seq_CD8_Mouse0.96129581
141GF1_26923725_Chip-Seq_HPCs_Mouse0.96047102
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94642538
143STAT3_18555785_ChIP-Seq_MESCs_Mouse0.93778995
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92649849
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92019039
146CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91846157
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.91593022
148OCT4_20526341_ChIP-Seq_ESCs_Human0.90919761
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90821054
150PHF8_20622854_ChIP-Seq_HELA_Human0.90589558
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90587477
152TCF4_22108803_ChIP-Seq_LS180_Human0.90229831
153EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89825930
154NANOG_20526341_ChIP-Seq_ESCs_Human0.89303018
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89153551
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89002992
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88831500
158SMC4_20622854_ChIP-Seq_HELA_Human0.88772248
159RAC3_21632823_ChIP-Seq_H3396_Human0.88727543
160JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88679404
161TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88583059
162SOX2_21211035_ChIP-Seq_LN229_Human0.87725648
163EED_16625203_ChIP-ChIP_MESCs_Mouse0.87518576
164IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86985794
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86941616
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86887624
167CTCF_27219007_Chip-Seq_Bcells_Human0.86024762
168KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85930175
169GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84182365
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84176352
171CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84082033
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83726779
173NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83641005
174SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83184129
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.81830433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting6.35130065
2MP0003698_abnormal_male_reproductive4.68003626
3MP0000537_abnormal_urethra_morphology4.40311042
4MP0001929_abnormal_gametogenesis4.22091332
5MP0005167_abnormal_blood-brain_barrier3.29530901
6MP0003122_maternal_imprinting3.22029143
7MP0003878_abnormal_ear_physiology3.07970183
8MP0005377_hearing/vestibular/ear_phenot3.07970183
9MP0002234_abnormal_pharynx_morphology2.92447505
10MP0005423_abnormal_somatic_nervous2.59233493
11MP0002161_abnormal_fertility/fecundity2.49983718
12MP0001348_abnormal_lacrimal_gland2.42908021
13MP0005670_abnormal_white_adipose2.39674799
14MP0002210_abnormal_sex_determination2.20832834
15MP0003868_abnormal_feces_composition2.09741998
16MP0001501_abnormal_sleep_pattern2.09716843
17MP0002735_abnormal_chemical_nociception2.07828612
18MP0008877_abnormal_DNA_methylation2.00146717
19MP0005410_abnormal_fertilization13.3395649
20MP0002736_abnormal_nociception_after1.93111307
21MP0004742_abnormal_vestibular_system1.92015176
22MP0003121_genomic_imprinting1.90034611
23MP0001145_abnormal_male_reproductive1.88216900
24MP0008569_lethality_at_weaning1.86913968
25MP0002067_abnormal_sensory_capabilities1.86488393
26MP0008004_abnormal_stomach_pH1.85724580
27MP0001968_abnormal_touch/_nociception1.76084759
28MP0000653_abnormal_sex_gland1.73694888
29MP0003329_amyloid_beta_deposits1.72136161
30MP0003045_fibrosis1.57340727
31MP0003718_maternal_effect1.56924659
32MP0001727_abnormal_embryo_implantation1.54308458
33MP0001485_abnormal_pinna_reflex1.46543491
34MP0003632_abnormal_nervous_system1.32521321
35MP0009697_abnormal_copulation1.31416128
36MP0004808_abnormal_hematopoietic_stem1.30843855
37MP0008875_abnormal_xenobiotic_pharmacok1.29994786
38MP0002229_neurodegeneration1.23593064
39MP0000465_gastrointestinal_hemorrhage1.20700001
40MP0001984_abnormal_olfaction1.20387689
41MP0003943_abnormal_hepatobiliary_system1.20229531
42MP0000920_abnormal_myelination1.18284849
43MP0002822_catalepsy1.17734731
44MP0005646_abnormal_pituitary_gland1.16420958
45MP0002557_abnormal_social/conspecific_i1.15732169
46MP0005551_abnormal_eye_electrophysiolog1.15177616
47MP0004510_myositis1.15030147
48MP0003633_abnormal_nervous_system1.13408373
49MP0003942_abnormal_urinary_system1.12554208
50MP0002882_abnormal_neuron_morphology1.11050020
51MP0002733_abnormal_thermal_nociception1.10874793
52MP0001970_abnormal_pain_threshold1.09336844
53MP0000955_abnormal_spinal_cord1.09300386
54MP0003191_abnormal_cellular_cholesterol1.08667291
55MP0002160_abnormal_reproductive_system1.07669000
56MP0001440_abnormal_grooming_behavior1.07482271
57MP0003828_pulmonary_edema1.05790385
58MP0006276_abnormal_autonomic_nervous1.01569002
59MP0002184_abnormal_innervation0.98697969
60MP0000749_muscle_degeneration0.97029740
61MP0001664_abnormal_digestion0.96016406
62MP0000778_abnormal_nervous_system0.95967649
63MP0005395_other_phenotype0.95589812
64MP0002127_abnormal_cardiovascular_syste0.94270984
65MP0002653_abnormal_ependyma_morphology0.93930071
66MP0002066_abnormal_motor_capabilities/c0.91277805
67MP0005671_abnormal_response_to0.90262391
68MP0002138_abnormal_hepatobiliary_system0.88795684
69MP0001905_abnormal_dopamine_level0.88407743
70MP0002249_abnormal_larynx_morphology0.88056678
71MP0001765_abnormal_ion_homeostasis0.87982473
72MP0005464_abnormal_platelet_physiology0.87760106
73MP0000678_abnormal_parathyroid_gland0.87162818
74MP0009046_muscle_twitch0.87075062
75MP0005623_abnormal_meninges_morphology0.84934451
76MP0002139_abnormal_hepatobiliary_system0.84020914
77MP0005386_behavior/neurological_phenoty0.84005982
78MP0004924_abnormal_behavior0.84005982
79MP0005257_abnormal_intraocular_pressure0.83326510
80MP0001502_abnormal_circadian_rhythm0.82071127
81MP0005360_urolithiasis0.81135756
82MP0008872_abnormal_physiological_respon0.80151181
83MP0000569_abnormal_digit_pigmentation0.79781710
84MP0001853_heart_inflammation0.79278713
85MP0005379_endocrine/exocrine_gland_phen0.78748375
86MP0003646_muscle_fatigue0.78628340
87MP0000427_abnormal_hair_cycle0.78342972
88MP0001545_abnormal_hematopoietic_system0.76328555
89MP0005397_hematopoietic_system_phenotyp0.76328555
90MP0003638_abnormal_response/metabolism_0.75760591
91MP0005253_abnormal_eye_physiology0.75672917
92MP0004036_abnormal_muscle_relaxation0.74653807
93MP0003631_nervous_system_phenotype0.74606802
94MP0005499_abnormal_olfactory_system0.74483119
95MP0005394_taste/olfaction_phenotype0.74483119
96MP0010307_abnormal_tumor_latency0.74017269
97MP0001177_atelectasis0.72070818
98MP0002928_abnormal_bile_duct0.71519485
99MP0006036_abnormal_mitochondrial_physio0.70572549
100MP0009379_abnormal_foot_pigmentation0.67721278
101MP0000604_amyloidosis0.67606129
102MP0003183_abnormal_peptide_metabolism0.67048651
103MP0000026_abnormal_inner_ear0.66697205
104MP0002132_abnormal_respiratory_system0.66213540
105MP0003635_abnormal_synaptic_transmissio0.65944280
106MP0002837_dystrophic_cardiac_calcinosis0.65525617
107MP0004859_abnormal_synaptic_plasticity0.65363349
108MP0008775_abnormal_heart_ventricle0.65048030
109MP0009780_abnormal_chondrocyte_physiolo0.63582773
110MP0010386_abnormal_urinary_bladder0.62905641
111MP0000534_abnormal_ureter_morphology0.62121180
112MP0002152_abnormal_brain_morphology0.60498966
113MP0009115_abnormal_fat_cell0.60366743
114MP0008057_abnormal_DNA_replication0.59826367
115MP0005330_cardiomyopathy0.59419546
116MP0002168_other_aberrant_phenotype0.59295017
117MP0005248_abnormal_Harderian_gland0.58663532
118MP0002272_abnormal_nervous_system0.56487413
119MP0000566_synostosis0.55120260
120MP0009745_abnormal_behavioral_response0.55067859
121MP0005636_abnormal_mineral_homeostasis0.53870594
122MP0003806_abnormal_nucleotide_metabolis0.51205863
123MP0009278_abnormal_bone_marrow0.51011670
124MP0000639_abnormal_adrenal_gland0.50105843
125MP0002064_seizures0.48442108
126MP0004085_abnormal_heartbeat0.46060125
127MP0008058_abnormal_DNA_repair0.45548630
128MP0005666_abnormal_adipose_tissue0.44541961
129MP0000249_abnormal_blood_vessel0.44408671
130MP0003119_abnormal_digestive_system0.44105553
131MP0004233_abnormal_muscle_weight0.43894836
132MP0002295_abnormal_pulmonary_circulatio0.42974672
133MP0004084_abnormal_cardiac_muscle0.42420536
134MP0002282_abnormal_trachea_morphology0.41776289
135MP0002734_abnormal_mechanical_nocicepti0.41182019
136MP0000230_abnormal_systemic_arterial0.40532045
137MP0001486_abnormal_startle_reflex0.39891811
138MP0000428_abnormal_craniofacial_morphol0.39534578
139MP0003879_abnormal_hair_cell0.39010266
140MP0001666_abnormal_nutrient_absorption0.38867511
141MP0000490_abnormal_crypts_of0.38805915
142MP0001963_abnormal_hearing_physiology0.38553436
143MP0005085_abnormal_gallbladder_physiolo0.38259306
144MP0003866_abnormal_defecation0.37580540
145MP0002063_abnormal_learning/memory/cond0.35816875
146MP0005584_abnormal_enzyme/coenzyme_acti0.35799830
147MP0005647_abnormal_sex_gland0.35242494
148MP0000613_abnormal_salivary_gland0.34285201
149MP0008770_decreased_survivor_rate0.33482243
150MP0010368_abnormal_lymphatic_system0.32623794
151MP0005620_abnormal_muscle_contractility0.29112903
152MP0003699_abnormal_female_reproductive0.28620093
153MP0008874_decreased_physiological_sensi0.28525631
154MP0004145_abnormal_muscle_electrophysio0.28098232
155MP0004270_analgesia0.28064487
156MP0002572_abnormal_emotion/affect_behav0.27716492
157MP0004811_abnormal_neuron_physiology0.27382448
158MP0003880_abnormal_central_pattern0.24824092
159MP0003448_altered_tumor_morphology0.24792009

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)7.48409507
2Abnormal respiratory motile cilium morphology (HP:0005938)7.48409507
3Abnormal respiratory motile cilium physiology (HP:0012261)7.31275540
4Rhinitis (HP:0012384)6.10281622
5Infertility (HP:0000789)5.94587509
6Chronic bronchitis (HP:0004469)5.66561063
7Abnormal ciliary motility (HP:0012262)5.60253471
8Subacute progressive viral hepatitis (HP:0006572)5.58393438
9Chronic hepatic failure (HP:0100626)5.35149839
10Tubulointerstitial nephritis (HP:0001970)5.26634300
11Nasal polyposis (HP:0100582)5.06648264
12Postural instability (HP:0002172)4.72324318
13Retinal dysplasia (HP:0007973)4.69234168
14Type II lissencephaly (HP:0007260)4.55787289
15Focal motor seizures (HP:0011153)4.46142924
16Myokymia (HP:0002411)4.42261885
17Progressive cerebellar ataxia (HP:0002073)4.23697607
18Abnormality of the nasal mucosa (HP:0000433)4.13793928
19Resting tremor (HP:0002322)4.12225393
20Abnormal spermatogenesis (HP:0008669)3.99966334
21Micronodular cirrhosis (HP:0001413)3.95603141
22Bronchitis (HP:0012387)3.94871291
23Bronchiectasis (HP:0002110)3.76278757
24Male infertility (HP:0003251)3.76136334
25Severe visual impairment (HP:0001141)3.62604284
26Focal seizures (HP:0007359)3.43315617
27Cone-rod dystrophy (HP:0000548)3.40263919
28Hyperkalemia (HP:0002153)3.27082186
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.25690912
30Abnormality of macular pigmentation (HP:0008002)3.22508269
31Nephronophthisis (HP:0000090)3.19122095
32Viral hepatitis (HP:0006562)3.14780659
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.99683474
34Epileptic encephalopathy (HP:0200134)2.89335819
35Hepatocellular carcinoma (HP:0001402)2.82838673
36Attenuation of retinal blood vessels (HP:0007843)2.81036793
37Recurrent bronchitis (HP:0002837)2.80411444
38Bony spicule pigmentary retinopathy (HP:0007737)2.79227308
39Dyschromatopsia (HP:0007641)2.78889060
40Action tremor (HP:0002345)2.76971580
41Submucous cleft hard palate (HP:0000176)2.74096148
42Impulsivity (HP:0100710)2.73825477
43Progressive inability to walk (HP:0002505)2.71136820
44Menstrual irregularities (HP:0000858)2.67741601
45Recurrent sinusitis (HP:0011108)2.59810094
46Azoospermia (HP:0000027)2.59196471
47Absent speech (HP:0001344)2.57916122
48Ragged-red muscle fibers (HP:0003200)2.56005474
49Renovascular hypertension (HP:0100817)2.54537408
50Absence seizures (HP:0002121)2.53761064
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.49465633
52Horizontal nystagmus (HP:0000666)2.48808327
53Gaze-evoked nystagmus (HP:0000640)2.46104677
54Asymmetric septal hypertrophy (HP:0001670)2.46087769
55Truncal obesity (HP:0001956)2.42698580
56Hemiparesis (HP:0001269)2.42216219
57Atonic seizures (HP:0010819)2.41529823
58Stereotypic behavior (HP:0000733)2.40131564
59Ureteral duplication (HP:0000073)2.38283104
60Hypophosphatemic rickets (HP:0004912)2.37831499
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37747767
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37747767
63Hyperventilation (HP:0002883)2.35939577
64Poor eye contact (HP:0000817)2.35530701
65Cholecystitis (HP:0001082)2.35266276
66Abnormal gallbladder physiology (HP:0012438)2.35266276
67Menorrhagia (HP:0000132)2.32506542
68Abnormality of the renal medulla (HP:0100957)2.28362574
69Abnormality of dental color (HP:0011073)2.27732376
70Bell-shaped thorax (HP:0001591)2.23790666
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23707966
72Recurrent otitis media (HP:0000403)2.21897658
73Papilledema (HP:0001085)2.21317547
74Postaxial foot polydactyly (HP:0001830)2.21128706
75Thoracolumbar scoliosis (HP:0002944)2.19371381
76Abnormality of binocular vision (HP:0011514)2.16193182
77Diplopia (HP:0000651)2.16193182
78Thickened helices (HP:0000391)2.15502210
79Sensory axonal neuropathy (HP:0003390)2.13668706
80Truncal ataxia (HP:0002078)2.13068706
81Protruding tongue (HP:0010808)2.10664454
82Bradykinesia (HP:0002067)2.06795005
83Impaired platelet aggregation (HP:0003540)2.04164436
84Abnormal platelet function (HP:0011869)2.04164436
85Cutaneous finger syndactyly (HP:0010554)2.03188197
86Febrile seizures (HP:0002373)2.02773660
87Tubulointerstitial abnormality (HP:0001969)2.00100770
88Dynein arm defect of respiratory motile cilia (HP:0012255)11.1254481
89Absent/shortened dynein arms (HP:0200106)11.1254481
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3291803
91Medial flaring of the eyebrow (HP:0010747)1.99429133
92Dysmetria (HP:0001310)1.97863007
93Progressive sensorineural hearing impairment (HP:0000408)1.97029368
94Hypoplasia of the thymus (HP:0000778)1.96189505
95Lissencephaly (HP:0001339)1.95716044
96Inability to walk (HP:0002540)1.94545194
97Supranuclear gaze palsy (HP:0000605)1.94381737
98Nonprogressive disorder (HP:0003680)1.91924842
99Broad-based gait (HP:0002136)1.91221414
100Decreased central vision (HP:0007663)1.90414170
101Intellectual disability, profound (HP:0002187)1.89866534
102Dysdiadochokinesis (HP:0002075)1.89747579
103Progressive microcephaly (HP:0000253)1.89116879
104Clumsiness (HP:0002312)1.88975502
105Apathy (HP:0000741)1.87932594
106Abnormality of the vitreous humor (HP:0004327)1.84729492
107Dialeptic seizures (HP:0011146)1.84357885
108Anterior segment dysgenesis (HP:0007700)1.84187381
109Osteomalacia (HP:0002749)1.83529304
110Retinal atrophy (HP:0001105)1.82264988
111Optic nerve hypoplasia (HP:0000609)1.82252475
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80913115
113Recurrent corneal erosions (HP:0000495)1.80763899
114Enlarged epiphyses (HP:0010580)1.80637467
115Progressive muscle weakness (HP:0003323)1.79741011
116Portal hypertension (HP:0001409)1.76940155
117Intellectual disability, moderate (HP:0002342)1.76460272
118Abnormal social behavior (HP:0012433)1.75065744
119Impaired social interactions (HP:0000735)1.75065744
120Increased intramyocellular lipid droplets (HP:0012240)1.74761590
121Bundle branch block (HP:0011710)1.72694837
122Ankle clonus (HP:0011448)1.72268864
123Hypoalphalipoproteinemia (HP:0003233)1.71967172
124Status epilepticus (HP:0002133)1.71634684
125Cerebral inclusion bodies (HP:0100314)1.70995913
126Neurofibrillary tangles (HP:0002185)1.69777157
127Rapidly progressive (HP:0003678)1.69483918
128Urinary urgency (HP:0000012)1.68937138
129Sandal gap (HP:0001852)1.67709297
130Widely spaced teeth (HP:0000687)1.66564022
131Exercise-induced myalgia (HP:0003738)1.66339507
132Chin dimple (HP:0010751)1.65558466
133Abnormality of the hepatic vasculature (HP:0006707)1.65353530
134Short chin (HP:0000331)1.64941123
135Abnormality of the ischium (HP:0003174)1.64585838
136Depression (HP:0000716)1.64170261
137Polymicrogyria (HP:0002126)1.63622775
138Joint hemorrhage (HP:0005261)1.62924940
139Abnormal eating behavior (HP:0100738)1.62877662
140Median cleft lip (HP:0000161)1.62554243
141Hemorrhage of the eye (HP:0011885)1.62316429
142Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62133615
143Drooling (HP:0002307)1.61683441
144Increased muscle lipid content (HP:0009058)1.61574102
145Gonadotropin excess (HP:0000837)1.59963112
146Congenital malformation of the right heart (HP:0011723)1.57998293
147Double outlet right ventricle (HP:0001719)1.57998293
148Infantile muscular hypotonia (HP:0008947)1.57732551
149Non-midline cleft lip (HP:0100335)1.56688107
150Aplasia/Hypoplasia of the brainstem (HP:0007362)1.52559718
151Hypoplasia of the brainstem (HP:0002365)1.52559718
152Stroke (HP:0001297)1.52188904
153Hypercholesterolemia (HP:0003124)1.51417254
154Complete atrioventricular canal defect (HP:0001674)1.51290889
155Exercise-induced muscle cramps (HP:0003710)1.50396960
156Prolonged bleeding time (HP:0003010)1.50040716
157Pachygyria (HP:0001302)1.49690576
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.44479003
159Fatigable weakness (HP:0003473)1.43874817
160Abnormality of the neuromuscular junction (HP:0003398)1.43874817
161Aplasia/Hypoplasia of the lens (HP:0008063)1.43498462
162Stage 5 chronic kidney disease (HP:0003774)1.42391740
163Purpura (HP:0000979)1.41151353
164Aplasia/Hypoplasia affecting the retina (HP:0008061)1.39054939
165Impaired vibration sensation in the lower limbs (HP:0002166)1.38820742
166Type 2 muscle fiber atrophy (HP:0003554)1.37961083
167Agitation (HP:0000713)1.36765812
168Plagiocephaly (HP:0001357)1.36449651
169Gowers sign (HP:0003391)1.36121976
170Bile duct proliferation (HP:0001408)1.36023747
171Abnormal biliary tract physiology (HP:0012439)1.36023747
172Abnormality of the intrinsic pathway (HP:0010989)1.34757163
173Molar tooth sign on MRI (HP:0002419)1.32986261
174Abnormality of midbrain morphology (HP:0002418)1.32986261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.11800066
2PDK47.11800066
3TESK15.11036108
4PINK14.71107944
5PLK44.58637731
6PDK24.35142645
7PRKD33.79256998
8ICK3.44877295
9TIE12.71912129
10PLK22.66255705
11LATS12.35674301
12STK38L2.35331159
13MARK12.31538046
14MARK32.29700802
15MUSK2.25350201
16EPHA42.23777516
17MST1R2.23608094
18PRKD22.18452681
19TNK22.17679656
20DYRK32.13659401
21LATS22.12865038
22BRD42.07827890
23MAP3K92.04590569
24INSRR1.99284710
25EIF2AK11.98105453
26MAP4K21.97130661
27MAPK131.96979289
28GRK11.95229670
29MAP3K131.94455176
30PTK2B1.89114628
31CDK81.83305084
32RIPK11.81632323
33CCNB11.71094340
34MAP2K71.52324113
35FRK1.43372407
36STK391.42477964
37DYRK1B1.41648600
38BMX1.40080241
39PDPK11.39628745
40NEK61.36356340
41WNK41.34822479
42AKT31.33229503
43SIK21.29250687
44NTRK11.21124867
45EIF2AK31.20480849
46PDK11.18256959
47CAMK1G1.16560199
48ARAF1.12485079
49OBSCN1.11246234
50DDR21.10745673
51KSR21.09173879
52BRAF1.05686165
53STK380.99992744
54IRAK10.98390015
55TNIK0.94433660
56TYRO30.93945726
57SGK30.91522900
58RIPK40.89770380
59CAMKK20.89285833
60HIPK20.87497765
61PKN10.87058147
62CSNK1G30.85278916
63IRAK20.85052566
64CAMKK10.83954566
65ABL20.83856819
66CASK0.82097071
67MAPK70.81879016
68BCKDK0.81012963
69NME20.78406663
70CDK30.76065906
71PAK60.74662153
72DAPK10.74067609
73SGK10.73572173
74FES0.68719964
75CSNK1G20.65409309
76IRAK40.64454414
77CAMK40.64238024
78MAP3K20.63862400
79DAPK20.62500341
80MINK10.61673142
81CDK190.60757785
82PRKCG0.60342869
83MAP3K10.60017432
84BMPR1B0.56386250
85PIK3CG0.56206312
86TTK0.55501362
87FGFR20.54879441
88CAMK1D0.50457759
89MAP3K120.50196957
90RET0.49893909
91BTK0.49042330
92WNK10.48751132
93MAPK100.47599755
94MYLK0.47494069
95HCK0.45617297
96ROCK10.45586224
97NTRK20.45171736
98PAK40.44674965
99MAP3K100.44362101
100CSF1R0.43960819
101PRKCH0.43593362
102MAPK150.42639899
103MARK20.42247310
104NTRK30.41307827
105RPS6KB10.40703226
106MAP3K70.38721078
107TGFBR10.38682542
108NEK20.37707176
109PRKCQ0.37073992
110PRKG20.37023415
111CSNK1G10.36023661
112MET0.35630489
113CHEK20.35461537
114CSNK1D0.35348703
115GSK3B0.34709379
116PRKCD0.34196239
117RPS6KA30.33834434
118MAPK10.33442896
119MAPK120.31560150
120YES10.30945861
121PRKCB0.30681929
122PRKCZ0.30651605
123MAPK110.29944206
124PASK0.29654024
125PNCK0.28618742
126STK110.28086281
127CDK50.27684213
128PRKACB0.27165961
129CDK140.26693433
130NME10.25709622
131CSNK1A10.25621131
132SYK0.25518891
133MAP2K60.23029372
134MAP3K80.22796085
135SGK20.21544083
136IRAK30.20741511
137UHMK10.20619945
138OXSR10.20155438
139PRKG10.19008110
140PRKD10.17581518
141PKN20.16269720
142ATR0.16079021
143CAMK10.16002740
144GSK3A0.14722931
145CSNK1A1L0.14232025
146CDK120.13457324
147CHEK10.12458144
148CAMK2B0.11925299
149LMTK20.11672011
150SGK2230.10814820
151SGK4940.10814820
152CAMK2A0.09813976
153RPS6KA10.09079571
154MAP3K40.08935652
155EPHB10.07995748
156EIF2AK20.07294905
157CSNK2A10.06004517
158KIT0.05697717
159MAPKAPK20.05150185
160RPS6KA40.05052810
161DAPK30.03706728

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.31522363
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.65857800
3Vitamin B6 metabolism_Homo sapiens_hsa007503.63034224
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80501611
5Glucagon signaling pathway_Homo sapiens_hsa049222.78058820
6Propanoate metabolism_Homo sapiens_hsa006402.43108559
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40490019
8Pyruvate metabolism_Homo sapiens_hsa006202.39167829
9Amphetamine addiction_Homo sapiens_hsa050312.11221857
10Linoleic acid metabolism_Homo sapiens_hsa005912.08984434
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06836466
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03255003
13Renin secretion_Homo sapiens_hsa049241.98736004
14PPAR signaling pathway_Homo sapiens_hsa033201.83968788
15Taste transduction_Homo sapiens_hsa047421.81156019
16Chemical carcinogenesis_Homo sapiens_hsa052041.79066900
17GABAergic synapse_Homo sapiens_hsa047271.77235625
18Gap junction_Homo sapiens_hsa045401.75272327
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73804778
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64982763
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63638253
22ABC transporters_Homo sapiens_hsa020101.59340268
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56692967
24Cardiac muscle contraction_Homo sapiens_hsa042601.54202820
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53019371
26Mineral absorption_Homo sapiens_hsa049781.49868246
27Selenocompound metabolism_Homo sapiens_hsa004501.47633477
28Fatty acid metabolism_Homo sapiens_hsa012121.46300499
29Butanoate metabolism_Homo sapiens_hsa006501.45263735
30Synaptic vesicle cycle_Homo sapiens_hsa047211.45097239
31Collecting duct acid secretion_Homo sapiens_hsa049661.44986495
32Fatty acid degradation_Homo sapiens_hsa000711.43062025
33Cholinergic synapse_Homo sapiens_hsa047251.41400861
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39049924
35Salivary secretion_Homo sapiens_hsa049701.37628700
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35936312
37Type II diabetes mellitus_Homo sapiens_hsa049301.32969627
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32167394
39Circadian entrainment_Homo sapiens_hsa047131.31824373
40Glycerolipid metabolism_Homo sapiens_hsa005611.30469631
41Purine metabolism_Homo sapiens_hsa002301.28473507
42Insulin secretion_Homo sapiens_hsa049111.24583667
43Folate biosynthesis_Homo sapiens_hsa007901.21556539
44Arginine biosynthesis_Homo sapiens_hsa002201.21081175
45Protein digestion and absorption_Homo sapiens_hsa049741.19885028
46Carbon metabolism_Homo sapiens_hsa012001.13919002
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08449083
48Long-term potentiation_Homo sapiens_hsa047201.08191688
49Long-term depression_Homo sapiens_hsa047301.07803933
50Huntingtons disease_Homo sapiens_hsa050161.05401994
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.03828800
52Gastric acid secretion_Homo sapiens_hsa049711.01578167
53Basal cell carcinoma_Homo sapiens_hsa052170.95949951
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93799397
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92994844
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92019954
57Fat digestion and absorption_Homo sapiens_hsa049750.87874965
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87635878
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87132060
60Complement and coagulation cascades_Homo sapiens_hsa046100.84986766
61Choline metabolism in cancer_Homo sapiens_hsa052310.83829935
62Caffeine metabolism_Homo sapiens_hsa002320.82924175
63Bile secretion_Homo sapiens_hsa049760.82674724
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82485832
65mRNA surveillance pathway_Homo sapiens_hsa030150.82196574
66Phototransduction_Homo sapiens_hsa047440.82020944
67Oocyte meiosis_Homo sapiens_hsa041140.81465165
68Serotonergic synapse_Homo sapiens_hsa047260.79752207
69Basal transcription factors_Homo sapiens_hsa030220.79103362
70Nicotine addiction_Homo sapiens_hsa050330.78504081
71Pentose phosphate pathway_Homo sapiens_hsa000300.77807811
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77257606
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.76449049
74Glutathione metabolism_Homo sapiens_hsa004800.76247184
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.75733304
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75715337
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.75232437
78MAPK signaling pathway_Homo sapiens_hsa040100.73932780
79Biosynthesis of amino acids_Homo sapiens_hsa012300.73542861
80Nitrogen metabolism_Homo sapiens_hsa009100.72904220
81Arachidonic acid metabolism_Homo sapiens_hsa005900.71538136
82Wnt signaling pathway_Homo sapiens_hsa043100.70621508
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.68861695
84Glutamatergic synapse_Homo sapiens_hsa047240.68770633
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67946312
86Antigen processing and presentation_Homo sapiens_hsa046120.67793643
87Oxytocin signaling pathway_Homo sapiens_hsa049210.67583704
88Thyroid hormone synthesis_Homo sapiens_hsa049180.67224428
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.67103277
90Glioma_Homo sapiens_hsa052140.66934549
91Fructose and mannose metabolism_Homo sapiens_hsa000510.66680227
92GnRH signaling pathway_Homo sapiens_hsa049120.65770665
93Calcium signaling pathway_Homo sapiens_hsa040200.65494840
94Inositol phosphate metabolism_Homo sapiens_hsa005620.65020601
95VEGF signaling pathway_Homo sapiens_hsa043700.64098128
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.63809215
97Histidine metabolism_Homo sapiens_hsa003400.63071329
98Pancreatic secretion_Homo sapiens_hsa049720.62892729
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62629870
100ErbB signaling pathway_Homo sapiens_hsa040120.62582290
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62440001
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62353512
103Hedgehog signaling pathway_Homo sapiens_hsa043400.62320946
104Estrogen signaling pathway_Homo sapiens_hsa049150.61631069
105Cocaine addiction_Homo sapiens_hsa050300.59717076
106Melanogenesis_Homo sapiens_hsa049160.59651802
107Parkinsons disease_Homo sapiens_hsa050120.59523212
108B cell receptor signaling pathway_Homo sapiens_hsa046620.59499155
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.58315452
110mTOR signaling pathway_Homo sapiens_hsa041500.57013313
111Renin-angiotensin system_Homo sapiens_hsa046140.55412270
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52580373
113Alzheimers disease_Homo sapiens_hsa050100.52146807
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51032616
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50734665
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49877782
117Ether lipid metabolism_Homo sapiens_hsa005650.49565642
118Circadian rhythm_Homo sapiens_hsa047100.48513596
119Pyrimidine metabolism_Homo sapiens_hsa002400.47196556
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.45792282
121Olfactory transduction_Homo sapiens_hsa047400.45738991
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45569856
123Alcoholism_Homo sapiens_hsa050340.44961775
124Endocytosis_Homo sapiens_hsa041440.44836492
125Platelet activation_Homo sapiens_hsa046110.44790558
126Oxidative phosphorylation_Homo sapiens_hsa001900.44559448
127Endometrial cancer_Homo sapiens_hsa052130.44093646
128Ovarian steroidogenesis_Homo sapiens_hsa049130.42511160
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41624836
130Morphine addiction_Homo sapiens_hsa050320.40572336
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39032192
132Apoptosis_Homo sapiens_hsa042100.38092084
133Rap1 signaling pathway_Homo sapiens_hsa040150.36975620
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36706911
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.36119429
136Dorso-ventral axis formation_Homo sapiens_hsa043200.35013642
137Vibrio cholerae infection_Homo sapiens_hsa051100.34713282
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34582320
139HIF-1 signaling pathway_Homo sapiens_hsa040660.34156509
140Ras signaling pathway_Homo sapiens_hsa040140.31604143
141Systemic lupus erythematosus_Homo sapiens_hsa053220.31400944
142T cell receptor signaling pathway_Homo sapiens_hsa046600.30166690
143cAMP signaling pathway_Homo sapiens_hsa040240.29536465
144Axon guidance_Homo sapiens_hsa043600.29234291
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28995325
146Dopaminergic synapse_Homo sapiens_hsa047280.26979310
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26819682
148Legionellosis_Homo sapiens_hsa051340.25794600
149Tight junction_Homo sapiens_hsa045300.24771264
150Prostate cancer_Homo sapiens_hsa052150.24495051

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