PRSS50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.91695291
2thrombin receptor signaling pathway (GO:0070493)5.81694601
3ribosomal small subunit assembly (GO:0000028)5.66796650
4heme biosynthetic process (GO:0006783)5.63893665
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.59013200
6blood coagulation, intrinsic pathway (GO:0007597)5.48510031
7protein neddylation (GO:0045116)5.42425103
8negative regulation of heart rate (GO:0010459)5.26850892
9viral transcription (GO:0019083)4.91720225
10folic acid-containing compound biosynthetic process (GO:0009396)4.79694075
11translational termination (GO:0006415)4.79541927
12protoporphyrinogen IX biosynthetic process (GO:0006782)4.78635714
13DNA replication initiation (GO:0006270)4.78590527
14DNA strand elongation involved in DNA replication (GO:0006271)4.76988752
15protoporphyrinogen IX metabolic process (GO:0046501)4.70495889
16heme metabolic process (GO:0042168)4.69667872
17telomere maintenance via semi-conservative replication (GO:0032201)4.67646855
18synaptonemal complex assembly (GO:0007130)4.60867805
19synaptonemal complex organization (GO:0070193)4.53721885
20male meiosis (GO:0007140)4.52441255
21DNA strand elongation (GO:0022616)4.51267111
22positive regulation of endothelial cell differentiation (GO:0045603)4.49103316
23fusion of sperm to egg plasma membrane (GO:0007342)4.47674220
24male meiosis I (GO:0007141)4.44878522
25porphyrin-containing compound biosynthetic process (GO:0006779)4.43936976
26negative regulation of thymocyte apoptotic process (GO:0070244)4.43728286
27translational elongation (GO:0006414)4.38799427
28meiosis I (GO:0007127)4.35524593
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33979683
30positive regulation of receptor recycling (GO:0001921)4.33816505
31DNA replication checkpoint (GO:0000076)4.33624796
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33316297
33synapsis (GO:0007129)4.30055116
34maturation of SSU-rRNA (GO:0030490)4.25610637
35adenosine receptor signaling pathway (GO:0001973)4.23727187
36cotranslational protein targeting to membrane (GO:0006613)4.21601171
37protein targeting to ER (GO:0045047)4.21200674
38ribosomal small subunit biogenesis (GO:0042274)4.20364678
39chromosome organization involved in meiosis (GO:0070192)4.20292212
40regulation of integrin-mediated signaling pathway (GO:2001044)4.14264615
41deoxyribose phosphate biosynthetic process (GO:0046385)4.09299133
422-deoxyribonucleotide biosynthetic process (GO:0009265)4.09299133
43CENP-A containing nucleosome assembly (GO:0034080)4.09001195
44regulation of platelet activation (GO:0010543)4.08064126
45protein localization to endoplasmic reticulum (GO:0070972)4.04645253
46chromatin remodeling at centromere (GO:0031055)4.03919418
47piRNA metabolic process (GO:0034587)4.03435884
48negative regulation of platelet activation (GO:0010544)4.00260438
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.99766489
50folic acid metabolic process (GO:0046655)3.96767025
51regulation of skeletal muscle contraction (GO:0014819)3.96605800
52platelet aggregation (GO:0070527)3.96341470
53translational initiation (GO:0006413)3.96082444
54negative regulation of response to food (GO:0032096)3.95880063
55negative regulation of appetite (GO:0032099)3.95880063
56tetrapyrrole biosynthetic process (GO:0033014)3.95212255
57positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.92921979
58leukocyte migration involved in inflammatory response (GO:0002523)3.92911037
59neutrophil activation involved in immune response (GO:0002283)3.90822815
60proteasome assembly (GO:0043248)3.90516342
61pseudouridine synthesis (GO:0001522)3.90093335
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87479516
63telomere maintenance via recombination (GO:0000722)3.87169158
64positive regulation of protein kinase C signaling (GO:0090037)3.84163559
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82662124
66L-phenylalanine catabolic process (GO:0006559)3.82662124
67regulation of platelet aggregation (GO:0090330)3.81646824
68regulation of meiosis I (GO:0060631)3.80396360
69DNA replication-dependent nucleosome assembly (GO:0006335)3.79263897
70DNA replication-dependent nucleosome organization (GO:0034723)3.79263897
71negative regulation of protein localization to cell surface (GO:2000009)3.78544038
72negative regulation of homotypic cell-cell adhesion (GO:0034111)3.76542913
73ribonucleoprotein complex biogenesis (GO:0022613)3.76323160
74ribosomal large subunit biogenesis (GO:0042273)3.74050746
75one-carbon compound transport (GO:0019755)3.74045966
76DNA unwinding involved in DNA replication (GO:0006268)3.72808987
77protein autoprocessing (GO:0016540)3.72590180
78DNA replication-independent nucleosome assembly (GO:0006336)3.71354079
79DNA replication-independent nucleosome organization (GO:0034724)3.71354079
80porphyrin-containing compound metabolic process (GO:0006778)3.71043000
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.70867981
82formation of translation preinitiation complex (GO:0001731)3.70568467
83ribosome biogenesis (GO:0042254)3.68540773
84viral life cycle (GO:0019058)3.66132437
85cardiolipin metabolic process (GO:0032048)3.64827374
86cellular protein complex disassembly (GO:0043624)3.64239331
87deoxyribonucleotide biosynthetic process (GO:0009263)3.62092733
88high-density lipoprotein particle remodeling (GO:0034375)3.61923295
89L-phenylalanine metabolic process (GO:0006558)3.61494832
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61494832
91DNA methylation involved in gamete generation (GO:0043046)3.61037787
92regulation of lipoprotein metabolic process (GO:0050746)3.60006893
93regulation of endothelial cell differentiation (GO:0045601)3.59897261
94regulation of histone H3-K9 methylation (GO:0051570)3.56095314
95spliceosomal snRNP assembly (GO:0000387)3.55448445
96positive regulation of cAMP-mediated signaling (GO:0043950)3.54949660
97negative regulation of norepinephrine secretion (GO:0010700)3.54826807
98pteridine-containing compound biosynthetic process (GO:0042559)3.54550562
99negative regulation of heart contraction (GO:0045822)3.54250019
100vesicle targeting (GO:0006903)3.49788255
101actin-myosin filament sliding (GO:0033275)3.49021880
102muscle filament sliding (GO:0030049)3.49021880
103translation (GO:0006412)3.48979421
104mitotic recombination (GO:0006312)3.47641794
105erythrocyte maturation (GO:0043249)3.45773952
106establishment of integrated proviral latency (GO:0075713)3.45303669
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44148591
108translesion synthesis (GO:0019985)3.43215042
109histone exchange (GO:0043486)3.41909303
110lysine metabolic process (GO:0006553)3.41470061
111lysine catabolic process (GO:0006554)3.41470061
112positive regulation of Rho protein signal transduction (GO:0035025)3.38494696
113low-density lipoprotein particle remodeling (GO:0034374)3.37614501
114reverse cholesterol transport (GO:0043691)3.35460592
115platelet degranulation (GO:0002576)3.33049820
116rRNA processing (GO:0006364)3.32573249
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.31784250
118negative regulation of calcium ion transmembrane transport (GO:1903170)3.31784250
119termination of RNA polymerase III transcription (GO:0006386)3.30881137
120transcription elongation from RNA polymerase III promoter (GO:0006385)3.30881137
121meiotic nuclear division (GO:0007126)3.30772810
122mitotic nuclear envelope disassembly (GO:0007077)3.30120646
123regulation of female receptivity (GO:0045924)3.29729824
124rRNA modification (GO:0000154)3.29152285
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28430357
126telomere maintenance via telomere lengthening (GO:0010833)3.28328251
127IMP biosynthetic process (GO:0006188)3.28158807
128lipoxygenase pathway (GO:0019372)3.26386155
129plasma membrane fusion (GO:0045026)3.25417775
130negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.25000924
131protein complex disassembly (GO:0043241)3.24912644
132regulation of Golgi to plasma membrane protein transport (GO:0042996)3.23943984
133rRNA metabolic process (GO:0016072)3.23342620
134negative regulation of RNA splicing (GO:0033119)3.22144467
135regulation of receptor recycling (GO:0001919)3.21717546
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19767390
137pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19125098
138angiogenesis involved in wound healing (GO:0060055)3.18345345
139sarcoplasmic reticulum calcium ion transport (GO:0070296)3.16944791
140glycerophospholipid catabolic process (GO:0046475)3.16901653
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.14297461
142negative regulation of gluconeogenesis (GO:0045721)3.13742739
143histone mRNA metabolic process (GO:0008334)3.12536134
144pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.11376785
145nucleotide-excision repair, DNA gap filling (GO:0006297)3.10483041
146cellular component biogenesis (GO:0044085)3.09198896
147spliceosomal complex assembly (GO:0000245)3.09119084
148nuclear-transcribed mRNA catabolic process (GO:0000956)3.08432675
149negative regulation of neural precursor cell proliferation (GO:2000178)3.07980094
150oxidative phosphorylation (GO:0006119)3.07341387
151macromolecular complex disassembly (GO:0032984)3.06964853
152histone H3-K9 demethylation (GO:0033169)3.06494404
153positive regulation of meiosis (GO:0045836)3.06147474
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05682265
155actin-mediated cell contraction (GO:0070252)3.05660451
156membrane disassembly (GO:0030397)3.05438661
157nuclear envelope disassembly (GO:0051081)3.05438661
158DNA synthesis involved in DNA repair (GO:0000731)3.04549155
159kinetochore assembly (GO:0051382)3.03995259
160termination of RNA polymerase II transcription (GO:0006369)3.03465734
161kinetochore organization (GO:0051383)3.03117649
162protein localization to chromosome, centromeric region (GO:0071459)3.02506817
163pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01437841
164positive regulation of insulin receptor signaling pathway (GO:0046628)2.99574830
165pigment biosynthetic process (GO:0046148)2.99012571
166mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98215772
167polyamine biosynthetic process (GO:0006596)2.97197872
168regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.95932068
169nucleobase biosynthetic process (GO:0046112)2.94830695
170pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.94689171
171regulation of mitochondrial translation (GO:0070129)2.92909035
172platelet formation (GO:0030220)2.92315321
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91980831
174neuronal action potential propagation (GO:0019227)2.91576983
175mRNA catabolic process (GO:0006402)2.90971328
176positive regulation of protein homodimerization activity (GO:0090073)2.90786973
177positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.90559184
178positive regulation of systemic arterial blood pressure (GO:0003084)2.90306454
179myelination in peripheral nervous system (GO:0022011)2.90061692
180peripheral nervous system axon ensheathment (GO:0032292)2.90061692
181skeletal muscle contraction (GO:0003009)2.87932086
182negative regulation of blood circulation (GO:1903523)2.86564037
183phospholipid homeostasis (GO:0055091)2.85312839
184positive regulation of meiotic cell cycle (GO:0051446)2.84141898
185skeletal muscle tissue regeneration (GO:0043403)2.83788865
186myofibril assembly (GO:0030239)2.83104362
187beta-amyloid metabolic process (GO:0050435)2.82126297
188regulation of hydrogen peroxide metabolic process (GO:0010310)2.80201504
189meiotic chromosome segregation (GO:0045132)2.78814694
190platelet activation (GO:0030168)2.69145357
191negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69024517
192relaxation of smooth muscle (GO:0044557)2.68674798
193termination of G-protein coupled receptor signaling pathway (GO:0038032)2.67739516
194cardiac myofibril assembly (GO:0055003)2.67726527
195negative regulation of catecholamine secretion (GO:0033604)2.65866574
196termination of signal transduction (GO:0023021)2.65741779
197peptide catabolic process (GO:0043171)2.63400203
198female mating behavior (GO:0060180)2.61657609
199monoamine transport (GO:0015844)2.59931110
200regulation of cilium movement (GO:0003352)2.58345933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99933664
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.89871861
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87391495
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.65274885
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.04268389
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13936674
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11092284
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02544497
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01974149
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99252504
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.97037321
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.96662909
13EZH2_22144423_ChIP-Seq_EOC_Human2.96258153
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.92397763
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78056087
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69926623
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68521068
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57910972
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49673397
20XRN2_22483619_ChIP-Seq_HELA_Human2.41001065
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34909643
22VDR_23849224_ChIP-Seq_CD4+_Human2.33251181
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32381457
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28995366
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28460731
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23878179
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22151222
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19436782
29DCP1A_22483619_ChIP-Seq_HELA_Human2.18105973
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17544960
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11551262
32GABP_19822575_ChIP-Seq_HepG2_Human2.11098673
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11032135
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06697050
35GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06124786
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05766287
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01757101
38FOXM1_23109430_ChIP-Seq_U2OS_Human2.01450602
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98549421
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98142191
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97037893
42AR_21909140_ChIP-Seq_LNCAP_Human1.96416827
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93540057
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.92973014
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.89569786
46FOXP3_21729870_ChIP-Seq_TREG_Human1.88584369
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87808056
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85548058
49TTF2_22483619_ChIP-Seq_HELA_Human1.85232434
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83401291
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82356856
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80196279
53GATA1_19941826_ChIP-Seq_K562_Human1.79528371
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72522826
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.72461049
56HTT_18923047_ChIP-ChIP_STHdh_Human1.70764342
57GATA1_22025678_ChIP-Seq_K562_Human1.69559398
58CTCF_27219007_Chip-Seq_Bcells_Human1.69165035
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68747730
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66939095
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.66404989
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.64588445
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64278561
64DROSHA_22980978_ChIP-Seq_HELA_Human1.64122955
65GATA2_19941826_ChIP-Seq_K562_Human1.63759780
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.62584763
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57603491
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56123058
69MYC_22102868_ChIP-Seq_BL_Human1.55011806
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52658040
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51856570
72P68_20966046_ChIP-Seq_HELA_Human1.49035828
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43114689
74KDM5A_27292631_Chip-Seq_BREAST_Human1.42981837
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42513795
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41641997
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41124465
78ELK1_19687146_ChIP-ChIP_HELA_Human1.40751702
79* LXR_22292898_ChIP-Seq_THP-1_Human1.38563516
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38269376
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38260005
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36979301
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35013333
84CIITA_25753668_ChIP-Seq_RAJI_Human1.34758667
85SMC4_20622854_ChIP-Seq_HELA_Human1.33913383
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31990529
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.31587608
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29771691
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29084017
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.28537387
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.28032501
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27654384
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24781814
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.23510220
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.22955067
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22538586
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20954943
98ZNF263_19887448_ChIP-Seq_K562_Human1.20927851
99GATA1_19941827_ChIP-Seq_MEL86_Mouse1.20807833
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20663571
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19531011
102SCL_19346495_ChIP-Seq_HPC-7_Human1.18507806
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17805566
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16979646
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.16110048
106* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16014954
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14845290
108BCL6_27268052_Chip-Seq_Bcells_Human1.14716224
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.14028079
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13830838
111SPI1_20517297_ChIP-Seq_HL60_Human1.13245997
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13234230
113* TP63_22573176_ChIP-Seq_HFKS_Human1.12823932
114RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12022017
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11542928
116VDR_21846776_ChIP-Seq_THP-1_Human1.11327693
117BCOR_27268052_Chip-Seq_Bcells_Human1.10781655
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10052783
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09876552
120RNF2_27304074_Chip-Seq_NSC_Mouse1.09154829
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08537013
122* GATA3_21867929_ChIP-Seq_CD8_Mouse1.08247351
123EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08035792
124SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07874708
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.07770460
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07585788
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07286756
128OCT4_20526341_ChIP-Seq_ESCs_Human1.06183220
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.04779298
130TFEB_21752829_ChIP-Seq_HELA_Human1.03650774
131SOX2_21211035_ChIP-Seq_LN229_Human1.03043997
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02835548
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02254382
134CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01525229
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01053715
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00706320
137RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00132723
138SA1_27219007_Chip-Seq_Bcells_Human0.99719931
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.99695990
140HNFA_21074721_ChIP-Seq_CACO-2_Human0.99025725
141OCT4_19829295_ChIP-Seq_ESCs_Human0.98803849
142MYC_18940864_ChIP-ChIP_HL60_Human0.98691075
143PHF8_20622853_ChIP-Seq_HELA_Human0.98601955
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97979694
145CTCF_21964334_Chip-Seq_Bcells_Human0.97531299
146PHF8_20622854_ChIP-Seq_HELA_Human0.97451546
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97212300
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.95254281
149MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94816451
150* TET1_21451524_ChIP-Seq_MESCs_Mouse0.94796742
151NANOG_20526341_ChIP-Seq_ESCs_Human0.94602938
152SPI1_23127762_ChIP-Seq_K562_Human0.94000030
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.93869419
154TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92708088
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92360692
156* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91679856
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91518223
158MYC_19829295_ChIP-Seq_ESCs_Human0.91357970
159SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91356012
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91160140
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90771161
162E2F1_20622854_ChIP-Seq_HELA_Human0.90687472
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.90574602
164TBL1_22424771_ChIP-Seq_293T_Human0.90178303
165EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89704565
166RBPJ_21746931_ChIP-Seq_IB4_Human0.89636204
167SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89470194
168BCAT_22108803_ChIP-Seq_LS180_Human0.88935161
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88174501
170P300_27268052_Chip-Seq_Bcells_Human0.87897204
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87848684
172EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87756099
173EGR1_19374776_ChIP-ChIP_THP-1_Human0.87452761
174NFYB_21822215_ChIP-Seq_K562_Human0.87053661
175ERA_21632823_ChIP-Seq_H3396_Human0.86604954
176MYC_27129775_Chip-Seq_CORNEA_Mouse0.86522777
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.86447682
178CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86333057
179NFYA_21822215_ChIP-Seq_K562_Human0.85686223
180STAT1_20625510_ChIP-Seq_HELA_Human0.85351753
181NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84533224
182KLF4_19829295_ChIP-Seq_ESCs_Human0.84042822
183FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83819190
184SPI1_23547873_ChIP-Seq_NB4_Human0.83645814
185MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83460522
186CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82785887
187SPI1_26923725_Chip-Seq_HPCs_Mouse0.82664795
188RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82254702
189TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81680094
190SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81608940
191ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77958185
192ELK1_22589737_ChIP-Seq_MCF10A_Human0.76667973
193FOXP1_21924763_ChIP-Seq_HESCs_Human0.76075833
194EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75245013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.09555049
2MP0003656_abnormal_erythrocyte_physiolo6.69905057
3MP0004147_increased_porphyrin_level5.38863205
4MP0006054_spinal_hemorrhage4.92646981
5MP0003693_abnormal_embryo_hatching4.18990235
6MP0008004_abnormal_stomach_pH4.11963820
7MP0003806_abnormal_nucleotide_metabolis3.83213737
8MP0004957_abnormal_blastocyst_morpholog3.79534979
9MP0010094_abnormal_chromosome_stability3.70327785
10MP0008057_abnormal_DNA_replication3.70063861
11MP0004036_abnormal_muscle_relaxation3.52376972
12MP0004084_abnormal_cardiac_muscle3.50727446
13MP0003111_abnormal_nucleus_morphology3.49229603
14MP0005397_hematopoietic_system_phenotyp3.27887998
15MP0001545_abnormal_hematopoietic_system3.27887998
16MP0003136_yellow_coat_color3.05939607
17MP0003077_abnormal_cell_cycle2.99542146
18MP0002837_dystrophic_cardiac_calcinosis2.98640788
19MP0004510_myositis2.91766565
20MP0008058_abnormal_DNA_repair2.77873779
21MP0008877_abnormal_DNA_methylation2.74256908
22MP0002396_abnormal_hematopoietic_system2.61718343
23MP0010030_abnormal_orbit_morphology2.50383997
24MP0008007_abnormal_cellular_replicative2.44917863
25MP0000013_abnormal_adipose_tissue2.32611229
26MP0003879_abnormal_hair_cell2.27923027
27MP0003186_abnormal_redox_activity2.25122960
28MP0004130_abnormal_muscle_cell2.14686435
29MP0006036_abnormal_mitochondrial_physio2.07055552
30MP0000751_myopathy1.98997316
31MP0000230_abnormal_systemic_arterial1.96104418
32MP0003786_premature_aging1.95094693
33MP0009780_abnormal_chondrocyte_physiolo1.86750370
34MP0000678_abnormal_parathyroid_gland1.85420479
35MP0005058_abnormal_lysosome_morphology1.84394185
36MP0005620_abnormal_muscle_contractility1.84021013
37MP0006292_abnormal_olfactory_placode1.79835064
38MP0002972_abnormal_cardiac_muscle1.79452874
39MP0003566_abnormal_cell_adhesion1.76151746
40MP0003123_paternal_imprinting1.75578196
41MP0005083_abnormal_biliary_tract1.74786540
42MP0008932_abnormal_embryonic_tissue1.71021066
43MP0004215_abnormal_myocardial_fiber1.70647562
44MP0001879_abnormal_lymphatic_vessel1.68380049
45MP0002210_abnormal_sex_determination1.65256493
46MP0000383_abnormal_hair_follicle1.64195631
47MP0005670_abnormal_white_adipose1.64139246
48MP0000490_abnormal_crypts_of1.62152446
49MP0003638_abnormal_response/metabolism_1.58816919
50MP0001730_embryonic_growth_arrest1.55800266
51MP0005410_abnormal_fertilization1.52453669
52MP0001929_abnormal_gametogenesis1.51999926
53MP0002132_abnormal_respiratory_system1.51305318
54MP0001145_abnormal_male_reproductive1.49469353
55MP0000465_gastrointestinal_hemorrhage1.44346262
56MP0002106_abnormal_muscle_physiology1.42620925
57MP0009333_abnormal_splenocyte_physiolog1.41806684
58MP0000350_abnormal_cell_proliferation1.41289359
59MP0005636_abnormal_mineral_homeostasis1.37439919
60MP0002102_abnormal_ear_morphology1.34863730
61MP0005409_darkened_coat_color1.34006121
62MP0001968_abnormal_touch/_nociception1.33686008
63MP0005167_abnormal_blood-brain_barrier1.32955142
64MP0000313_abnormal_cell_death1.29800443
65MP0008995_early_reproductive_senescence1.28746076
66MP0000653_abnormal_sex_gland1.28606857
67MP0004085_abnormal_heartbeat1.28326702
68MP0004145_abnormal_muscle_electrophysio1.28099552
69MP0002139_abnormal_hepatobiliary_system1.27386228
70MP0001853_heart_inflammation1.23622725
71MP0000579_abnormal_nail_morphology1.21164480
72MP0005369_muscle_phenotype1.20877237
73MP0000358_abnormal_cell_content/1.20854526
74MP0001765_abnormal_ion_homeostasis1.18864275
75MP0009379_abnormal_foot_pigmentation1.18839092
76MP0010368_abnormal_lymphatic_system1.18668199
77MP0005385_cardiovascular_system_phenoty1.16193878
78MP0001544_abnormal_cardiovascular_syste1.16193878
79MP0002736_abnormal_nociception_after1.15865837
80MP0001661_extended_life_span1.15795445
81MP0003646_muscle_fatigue1.14844530
82MP0002398_abnormal_bone_marrow1.14135315
83MP0006035_abnormal_mitochondrial_morpho1.13695189
84MP0002653_abnormal_ependyma_morphology1.13491062
85MP0005646_abnormal_pituitary_gland1.13458687
86MP0004808_abnormal_hematopoietic_stem1.11754019
87MP0006138_congestive_heart_failure1.11573882
88MP0002080_prenatal_lethality1.11077231
89MP0008775_abnormal_heart_ventricle1.09683860
90MP0003698_abnormal_male_reproductive1.09430705
91MP0005666_abnormal_adipose_tissue1.08716792
92MP0003137_abnormal_impulse_conducting1.07812616
93MP0002019_abnormal_tumor_incidence1.06823732
94MP0000749_muscle_degeneration1.05202037
95MP0001849_ear_inflammation1.03865175
96MP0004087_abnormal_muscle_fiber1.03050206
97MP0010329_abnormal_lipoprotein_level1.02118340
98MP0000689_abnormal_spleen_morphology1.01533114
99MP0000003_abnormal_adipose_tissue1.01342159
100MP0002722_abnormal_immune_system1.00807229
101MP0004381_abnormal_hair_follicle0.99778638
102MP0002249_abnormal_larynx_morphology0.97351375
103MP0004134_abnormal_chest_morphology0.96814905
104MP0003453_abnormal_keratinocyte_physiol0.96361077
105MP0005375_adipose_tissue_phenotype0.95775346
106MP0001697_abnormal_embryo_size0.94862810
107MP0005266_abnormal_metabolism0.90806009
108MP0002429_abnormal_blood_cell0.88010901
109MP0005174_abnormal_tail_pigmentation0.87485228
110MP0002733_abnormal_thermal_nociception0.86545923
111MP0001764_abnormal_homeostasis0.86331660
112MP0005330_cardiomyopathy0.86108897
113MP0005377_hearing/vestibular/ear_phenot0.85788800
114MP0003878_abnormal_ear_physiology0.85788800
115MP0010352_gastrointestinal_tract_polyps0.84695864
116MP0004043_abnormal_pH_regulation0.83043208
117MP0003724_increased_susceptibility_to0.82690045
118MP0003763_abnormal_thymus_physiology0.82610211
119MP0005535_abnormal_body_temperature0.82082942
120MP0000703_abnormal_thymus_morphology0.81780011
121MP0001293_anophthalmia0.81120392
122MP0001915_intracranial_hemorrhage0.79274982
123MP0010307_abnormal_tumor_latency0.78159625
124MP0003172_abnormal_lysosome_physiology0.77831683
125MP0005075_abnormal_melanosome_morpholog0.76861623
126MP0003718_maternal_effect0.76708098
127MP0002089_abnormal_postnatal_growth/wei0.75654449
128MP0002254_reproductive_system_inflammat0.74978523
129MP0001970_abnormal_pain_threshold0.73924688
130MP0009642_abnormal_blood_homeostasis0.73405101
131MP0002282_abnormal_trachea_morphology0.73384780
132MP0003787_abnormal_imprinting0.72983941
133MP0002128_abnormal_blood_circulation0.72379072
134MP0004197_abnormal_fetal_growth/weight/0.72202232
135MP0002086_abnormal_extraembryonic_tissu0.72190275
136MP0008872_abnormal_physiological_respon0.67896578
137MP0010678_abnormal_skin_adnexa0.67770001
138MP0002161_abnormal_fertility/fecundity0.67652394
139MP0006276_abnormal_autonomic_nervous0.67574108
140MP0002160_abnormal_reproductive_system0.67263818
141MP0002234_abnormal_pharynx_morphology0.67080787
142MP0003195_calcinosis0.67004869
143MP0010630_abnormal_cardiac_muscle0.66947014
144MP0002118_abnormal_lipid_homeostasis0.65617283
145MP0005503_abnormal_tendon_morphology0.65114241
146MP0005248_abnormal_Harderian_gland0.64967160
147MP0002078_abnormal_glucose_homeostasis0.64882285
148MP0000685_abnormal_immune_system0.63805489
149MP0001756_abnormal_urination0.63580287
150MP0005380_embryogenesis_phenotype0.63564952
151MP0001672_abnormal_embryogenesis/_devel0.63564952
152MP0005023_abnormal_wound_healing0.62954522
153MP0004272_abnormal_basement_membrane0.62455289
154MP0005319_abnormal_enzyme/_coenzyme0.62150814
155MP0005448_abnormal_energy_balance0.61602475
156MP0003567_abnormal_fetal_cardiomyocyte0.60657784
157MP0002933_joint_inflammation0.60168093
158MP0005384_cellular_phenotype0.60138115
159MP0003011_delayed_dark_adaptation0.60036100
160MP0003984_embryonic_growth_retardation0.59972194
161MP0002735_abnormal_chemical_nociception0.59931834
162MP0005376_homeostasis/metabolism_phenot0.59037248
163MP0008469_abnormal_protein_level0.57330725
164MP0001188_hyperpigmentation0.56591312
165MP0000343_altered_response_to0.56320455
166MP0000598_abnormal_liver_morphology0.56239590
167MP0002088_abnormal_embryonic_growth/wei0.55194978
168MP0000609_abnormal_liver_physiology0.52826252
169MP0001727_abnormal_embryo_implantation0.52555406
170MP0001119_abnormal_female_reproductive0.52485894
171MP0000716_abnormal_immune_system0.52053233
172MP0001243_abnormal_dermal_layer0.50318559
173MP0002938_white_spotting0.48640538
174MP0005621_abnormal_cell_physiology0.48619290
175MP0001663_abnormal_digestive_system0.48191081
176MP0000858_altered_metastatic_potential0.46278982
177MP0005584_abnormal_enzyme/coenzyme_acti0.46108819

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.80186163
2Menorrhagia (HP:0000132)8.92503417
3Increased mean platelet volume (HP:0011877)8.60290945
4Abnormal number of erythroid precursors (HP:0012131)8.15123028
5Abnormal platelet volume (HP:0011876)7.88412028
6Abnormality of cells of the erythroid lineage (HP:0012130)7.82601304
7Purpura (HP:0000979)7.26013637
8Epistaxis (HP:0000421)5.70692632
9Irregular epiphyses (HP:0010582)5.61690360
10Hyperlipoproteinemia (HP:0010980)5.59660058
11Reticulocytopenia (HP:0001896)4.60247378
12Gingival bleeding (HP:0000225)4.59280209
13Birth length less than 3rd percentile (HP:0003561)4.52243191
14Pallor (HP:0000980)4.13801318
15Abnormality of reticulocytes (HP:0004312)3.96322811
16Nemaline bodies (HP:0003798)3.83969648
17Bundle branch block (HP:0011710)3.79737981
18Abnormal platelet function (HP:0011869)3.79585889
19Impaired platelet aggregation (HP:0003540)3.79585889
2011 pairs of ribs (HP:0000878)3.79308584
21Epiphyseal dysplasia (HP:0002656)3.75423526
22Muscle fiber inclusion bodies (HP:0100299)3.72382434
23Muscle fiber splitting (HP:0003555)3.70743791
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.69289455
25Aplastic anemia (HP:0001915)3.68062992
26Oral leukoplakia (HP:0002745)3.65249093
27Reticulocytosis (HP:0001923)3.60365242
28Poikilocytosis (HP:0004447)3.54076471
29Hyperthyroidism (HP:0000836)3.44988431
30Metaphyseal cupping (HP:0003021)3.33639487
31Increased serum ferritin (HP:0003281)3.29132208
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28265653
33Abnormality of lateral ventricle (HP:0030047)3.27996262
34Vitreoretinal degeneration (HP:0000655)3.25560040
35Exercise-induced myalgia (HP:0003738)3.21268448
36Spontaneous hematomas (HP:0007420)3.16850695
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.16681129
38Absent epiphyses (HP:0010577)3.16681129
39Diaphragmatic weakness (HP:0009113)3.14158611
40Macrocytic anemia (HP:0001972)3.11827254
41Spontaneous abortion (HP:0005268)3.09148681
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08704293
43Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08704293
44Acanthocytosis (HP:0001927)3.05779299
45Type 1 muscle fiber predominance (HP:0003803)3.03226773
46Hypophosphatemic rickets (HP:0004912)2.99316404
47Abnormality of iron homeostasis (HP:0011031)2.90531378
48Abnormality of transition element cation homeostasis (HP:0011030)2.87967450
49Abnormal spermatogenesis (HP:0008669)2.87251804
50Male infertility (HP:0003251)2.86967128
51Ventricular fibrillation (HP:0001663)2.82410902
52Rimmed vacuoles (HP:0003805)2.77155908
53Conjunctival telangiectasia (HP:0000524)2.76069148
54Abnormal pupillary function (HP:0007686)2.75261774
55Cupped ribs (HP:0000887)2.73730941
56Selective tooth agenesis (HP:0001592)2.72148882
57Sudden death (HP:0001699)2.69929933
58Abnormal mitochondria in muscle tissue (HP:0008316)2.68290116
59Hyperbilirubinemia (HP:0002904)2.68097548
60Ventricular tachycardia (HP:0004756)2.67212800
61Acute necrotizing encephalopathy (HP:0006965)2.67064650
62Mitochondrial inheritance (HP:0001427)2.63917411
63Hepatocellular necrosis (HP:0001404)2.60690078
64Azoospermia (HP:0000027)2.60138808
65Rough bone trabeculation (HP:0100670)2.56663756
66Increased CSF lactate (HP:0002490)2.53757057
67Abnormal tarsal ossification (HP:0008369)2.52566827
68Genu varum (HP:0002970)2.48050795
69Increased density of long bones (HP:0006392)2.48033094
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.47665028
71Increased serum lactate (HP:0002151)2.45643430
72Xanthomatosis (HP:0000991)2.43564512
73Small epiphyses (HP:0010585)2.43072662
74Carpal bone hypoplasia (HP:0001498)2.43060979
75Tongue fasciculations (HP:0001308)2.41989155
76Pancytopenia (HP:0001876)2.37430500
77Heart block (HP:0012722)2.35791169
78Breast hypoplasia (HP:0003187)2.35680757
79Bruising susceptibility (HP:0000978)2.35063647
80Cerebral hypomyelination (HP:0006808)2.34499921
81Secondary amenorrhea (HP:0000869)2.32752106
82Paralysis (HP:0003470)2.30356105
83Abnormality of femoral epiphyses (HP:0006499)2.28294400
84Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.28294400
85Abnormality of skeletal muscle fiber size (HP:0012084)2.27732184
86Hypoplastic ischia (HP:0003175)2.26408644
87Flat acetabular roof (HP:0003180)2.22968432
88Hepatic necrosis (HP:0002605)2.22908325
89Abnormal atrioventricular conduction (HP:0005150)2.22028555
90Acute encephalopathy (HP:0006846)2.21000043
91Distal lower limb muscle weakness (HP:0009053)2.20587311
92Infertility (HP:0000789)2.15763656
93Distal lower limb amyotrophy (HP:0008944)2.14505517
94Petechiae (HP:0000967)2.13862053
95Ventricular arrhythmia (HP:0004308)2.13216027
96Microretrognathia (HP:0000308)2.12144324
97Abnormality of the epiphysis of the femoral head (HP:0010574)2.11369682
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11258748
99Abnormality of the left ventricular outflow tract (HP:0011103)2.10630395
100Subaortic stenosis (HP:0001682)2.10630395
101Hip contracture (HP:0003273)2.09620553
102Severe visual impairment (HP:0001141)2.09509073
103Short femoral neck (HP:0100864)2.09385788
104Truncus arteriosus (HP:0001660)2.09255198
105Metaphyseal dysplasia (HP:0100255)2.05468818
106Chromsome breakage (HP:0040012)2.05279648
107Abnormality of the femoral head (HP:0003368)2.04779384
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04537177
109Nausea (HP:0002018)2.04419095
110Muscle fibrillation (HP:0010546)2.03749758
111Cerebellar dysplasia (HP:0007033)2.03642477
112Generalized aminoaciduria (HP:0002909)2.03478824
113Lipid accumulation in hepatocytes (HP:0006561)2.02736026
114Myelodysplasia (HP:0002863)2.02325247
115Round ear (HP:0100830)2.02098468
116Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02056686
117Myopathic facies (HP:0002058)2.01638211
118Gonadotropin excess (HP:0000837)2.01272831
119Abnormality of the common coagulation pathway (HP:0010990)1.99480102
120Flat capital femoral epiphysis (HP:0003370)1.99451982
121Prolonged bleeding time (HP:0003010)1.99023731
122Increased variability in muscle fiber diameter (HP:0003557)1.98370409
123Lactic acidosis (HP:0003128)1.98221031
124Abnormality of the preputium (HP:0100587)1.97902583
125Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.96119427
126Glossoptosis (HP:0000162)1.95715809
127Delayed epiphyseal ossification (HP:0002663)1.94582419
128Abnormal foot bone ossification (HP:0010675)1.93873640
129Abnormality of the anterior horn cell (HP:0006802)1.93587484
130Degeneration of anterior horn cells (HP:0002398)1.93587484
131Poor head control (HP:0002421)1.92193097
132Progressive muscle weakness (HP:0003323)1.92028849
133Short middle phalanx of the 5th finger (HP:0004220)1.90226121
134Progressive macrocephaly (HP:0004481)1.90029933
135Weak cry (HP:0001612)1.88445670
136Muscle hypertrophy of the lower extremities (HP:0008968)1.87498725
137Hyporeflexia of lower limbs (HP:0002600)1.87294189
138Respiratory failure (HP:0002878)1.86710196
139Increased intramyocellular lipid droplets (HP:0012240)1.85552405
140Exercise-induced muscle cramps (HP:0003710)1.84989480
141Increased muscle lipid content (HP:0009058)1.83863062
142Abnormality of alanine metabolism (HP:0010916)1.83401831
143Hyperalaninemia (HP:0003348)1.83401831
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83401831
145Hypoglycemic coma (HP:0001325)1.83039917
146Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82183603
147Insomnia (HP:0100785)1.81953741
148Arthropathy (HP:0003040)1.81868297
149Abnormality of the vertebral endplates (HP:0005106)1.81331982
150Dilated cardiomyopathy (HP:0001644)1.81100484
151Missing ribs (HP:0000921)1.80155589
152Abnormality of pyrimidine metabolism (HP:0004353)1.79887207
153Increased hepatocellular lipid droplets (HP:0006565)1.79307988
154Hypoplasia of the pons (HP:0012110)1.79103580
155Rhabdomyolysis (HP:0003201)1.78615658
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.76888228
157Difficulty climbing stairs (HP:0003551)1.76183700
158Flattened epiphyses (HP:0003071)1.74776103
159Atrial fibrillation (HP:0005110)1.74601230
160Irregular vertebral endplates (HP:0003301)1.74563960
161Abnormality of calcium-phosphate metabolism (HP:0100530)1.74169582
162Abnormality of the ischium (HP:0003174)1.73738760
163EMG: neuropathic changes (HP:0003445)1.73253744
164Papilledema (HP:0001085)1.73223196
165Enlarged penis (HP:0000040)1.73221085
166Myoglobinuria (HP:0002913)1.72823557
167Abnormality of chromosome stability (HP:0003220)1.72486147
168Beaking of vertebral bodies (HP:0004568)1.71441988
169Mild short stature (HP:0003502)1.70833365
170Broad palm (HP:0001169)1.69961511
171Bulbar palsy (HP:0001283)1.68266841
172Easy fatigability (HP:0003388)1.67063479
173Nuclear cataract (HP:0100018)1.66680202
174Central scotoma (HP:0000603)1.64989288
175Biliary tract neoplasm (HP:0100574)1.63998039
176Abnormal EKG (HP:0003115)1.63203099
177Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62393913
178Rickets (HP:0002748)1.61989799
179Hypophosphatemia (HP:0002148)1.61404582
180Waddling gait (HP:0002515)1.60929274
181Dyschromatopsia (HP:0007641)1.57732243
182Asymmetric septal hypertrophy (HP:0001670)1.56166480
183Gowers sign (HP:0003391)1.56046945
184Abnormality of the neuromuscular junction (HP:0003398)1.55747712
185Fatigable weakness (HP:0003473)1.55747712
186Joint swelling (HP:0001386)1.55463534
187Difficulty running (HP:0009046)1.55069538
188Hyperkalemia (HP:0002153)1.54743899
189Tinnitus (HP:0000360)1.54471397
190Primary atrial arrhythmia (HP:0001692)1.53702635
191Lower limb amyotrophy (HP:0007210)1.53437862
192J-shaped sella turcica (HP:0002680)1.52904104
193Dysautonomia (HP:0002459)1.52461169
194Supraventricular tachycardia (HP:0004755)1.51402454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX5.21549763
2MAPK154.63237555
3EIF2AK14.35850374
4CDC74.32978272
5NME23.97004369
6WEE13.55712554
7MYLK3.42191523
8PNCK3.21486630
9VRK13.01902021
10PTK2B2.97153327
11ACVR1B2.95746625
12SCYL22.84296890
13OBSCN2.67870732
14BUB12.62633961
15NEK22.47343901
16STK162.39587037
17RIPK42.34937696
18BRSK22.30651512
19PHKG22.29810789
20PHKG12.29810789
21DYRK32.11752046
22PIM22.04119421
23NME11.85769792
24PIK3CG1.84472206
25ATR1.79877818
26TTN1.78433553
27CDK71.69392261
28STK31.69213595
29KDR1.66080877
30TEC1.65907056
31BTK1.62300942
32MAP3K71.59319807
33EIF2AK31.56266440
34SRPK11.50568255
35TLK11.45727098
36PDK31.44693383
37PDK41.44693383
38PLK11.42907018
39NEK11.42761363
40MAP2K61.40154514
41BRSK11.34362806
42MET1.33325943
43RPS6KA41.33204415
44CDK121.30736674
45CDK191.27496805
46CDK41.26480782
47STK38L1.25912894
48DDR21.25152158
49EEF2K1.24365693
50BRD41.23297685
51ERBB21.22705285
52FGR1.22166141
53TTK1.20502638
54AURKB1.19720395
55ZAP701.18545861
56MAPKAPK51.17179358
57LRRK21.14700389
58RPS6KB21.12436669
59TAOK11.12061023
60PBK1.11081740
61MAP3K111.10196733
62MARK21.08512823
63NTRK31.08033113
64WNK41.03004383
65CHEK11.01793846
66TESK20.98746128
67TGFBR10.98420456
68MAPKAPK30.98187298
69PLK40.98171459
70GRK50.96599967
71AURKA0.96446048
72STK100.96184147
73BCKDK0.96019168
74DAPK30.95446385
75FLT30.94119662
76DAPK10.93538517
77PRKD10.93312833
78MKNK10.90898938
79PASK0.90049784
80ZAK0.90016578
81MAP3K100.88520978
82CDK80.88394790
83CAMK10.87969589
84CHEK20.87470845
85ATM0.87434336
86EPHB20.86476007
87TYK20.86304375
88DAPK20.85698107
89PDPK10.85405301
90PLK20.83490650
91MAPK120.83217473
92MAP3K30.81202184
93TRIB30.78399965
94CSNK2A20.77523336
95PAK40.77282844
96KIT0.77196274
97TBK10.77179125
98RAF10.76935930
99MAP3K80.76604483
100ROCK10.75932570
101NLK0.74057432
102ABL20.73346064
103STK240.72889258
104SIK10.72693002
105MAP2K30.72052673
106PDK20.71257906
107TSSK60.70295806
108RET0.70089698
109SYK0.69553522
110GRK60.69521855
111PKN10.69190484
112LMTK20.68636226
113MST40.67457124
114CSNK2A10.66391338
115CCNB10.65225129
116PDK10.64369196
117PIM10.63274961
118PDGFRB0.62811015
119CDK20.61790846
120ADRBK20.59005853
121STK40.58657331
122MKNK20.57966732
123PTK20.57669445
124STK380.57115395
125MAP4K10.56539385
126BLK0.56014400
127JAK20.53082442
128DYRK1B0.52275727
129PRKD30.51848799
130FRK0.51652605
131PRKG10.50062440
132TESK10.49935680
133MST1R0.49871075
134GRK10.49680833
135PAK30.43842429
136MUSK0.43709080
137TGFBR20.43633055
138FER0.43297976
139TNIK0.43095673
140MAP3K60.42403212
141MATK0.40263581
142RPS6KA50.39940014
143PKN20.39868430
144CDC42BPA0.39775938
145ITK0.39281859
146PRKDC0.38829898
147CDK10.38298311
148CAMKK20.37855906
149PRKG20.37539915
150CSK0.36600039
151MAPK110.35371649
152PLK30.35328041
153CAMK2D0.35109736
154MAPK70.35103871
155CSNK1G30.34921810
156PRKAA20.34773101
157TRIM280.34276544
158MARK30.33632546
159CAMK2G0.33351354
160HCK0.32873795
161MAP2K10.32452132
162INSRR0.32247951
163EIF2AK20.31758597
164CAMK2A0.31449295
165PAK20.31207453
166PAK10.31164591
167TNK20.31143326
168ILK0.30322605
169PRKACA0.30257640
170LYN0.29210064
171MAP3K50.29136448
172CSF1R0.27356097
173ADRBK10.26408204
174PRKD20.25053878
175PRKACG0.24736469
176PINK10.24714530
177JAK30.22953835

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.28591822
2Ribosome_Homo sapiens_hsa030104.54066949
3Platelet activation_Homo sapiens_hsa046114.38010578
4Mismatch repair_Homo sapiens_hsa034303.54293484
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38055511
6RNA polymerase_Homo sapiens_hsa030203.28490219
7Proteasome_Homo sapiens_hsa030503.08034302
8Spliceosome_Homo sapiens_hsa030403.03547816
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.96915371
10Pyrimidine metabolism_Homo sapiens_hsa002402.94761948
11Base excision repair_Homo sapiens_hsa034102.59567154
12RNA transport_Homo sapiens_hsa030132.58678010
13Homologous recombination_Homo sapiens_hsa034402.58061709
14Nucleotide excision repair_Homo sapiens_hsa034202.57679718
15One carbon pool by folate_Homo sapiens_hsa006702.40685865
16Vascular smooth muscle contraction_Homo sapiens_hsa042702.40511870
17Dilated cardiomyopathy_Homo sapiens_hsa054142.40348872
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37624825
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28910635
20Arachidonic acid metabolism_Homo sapiens_hsa005902.13519776
21Cell cycle_Homo sapiens_hsa041101.93696687
22Collecting duct acid secretion_Homo sapiens_hsa049661.88126625
23Fanconi anemia pathway_Homo sapiens_hsa034601.79942167
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78840168
25Parkinsons disease_Homo sapiens_hsa050121.78810959
26Fatty acid elongation_Homo sapiens_hsa000621.74259959
27Folate biosynthesis_Homo sapiens_hsa007901.72620727
28Nitrogen metabolism_Homo sapiens_hsa009101.71613110
29Sulfur relay system_Homo sapiens_hsa041221.69907735
30Basal transcription factors_Homo sapiens_hsa030221.68937235
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.64336447
32RNA degradation_Homo sapiens_hsa030181.62606877
33Non-homologous end-joining_Homo sapiens_hsa034501.60919803
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.60341148
35Oxidative phosphorylation_Homo sapiens_hsa001901.54235617
36Selenocompound metabolism_Homo sapiens_hsa004501.53598984
37Circadian rhythm_Homo sapiens_hsa047101.51679729
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51306915
39Purine metabolism_Homo sapiens_hsa002301.49960875
40Huntingtons disease_Homo sapiens_hsa050161.47224597
41Protein export_Homo sapiens_hsa030601.42097646
42Serotonergic synapse_Homo sapiens_hsa047261.36972380
43Gap junction_Homo sapiens_hsa045401.36840184
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34603326
45Focal adhesion_Homo sapiens_hsa045101.32427008
46Pentose phosphate pathway_Homo sapiens_hsa000301.31054123
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30079489
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29316705
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28323559
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26058663
51Calcium signaling pathway_Homo sapiens_hsa040201.22995266
52Regulation of autophagy_Homo sapiens_hsa041401.19527751
53p53 signaling pathway_Homo sapiens_hsa041151.16425488
54Notch signaling pathway_Homo sapiens_hsa043301.12154390
55Insulin secretion_Homo sapiens_hsa049111.11162940
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09320125
57Starch and sucrose metabolism_Homo sapiens_hsa005001.08952208
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.07496351
59Insulin signaling pathway_Homo sapiens_hsa049101.05975158
60Pancreatic secretion_Homo sapiens_hsa049721.01858733
61Glucagon signaling pathway_Homo sapiens_hsa049221.01609884
62mRNA surveillance pathway_Homo sapiens_hsa030151.01549656
63Glycerolipid metabolism_Homo sapiens_hsa005611.00889796
64Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00769841
65Tight junction_Homo sapiens_hsa045300.99394989
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96294737
67Ovarian steroidogenesis_Homo sapiens_hsa049130.95383667
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94917340
69Caffeine metabolism_Homo sapiens_hsa002320.93100833
70Endocytosis_Homo sapiens_hsa041440.93078056
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92985232
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92188983
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91418929
74Pyruvate metabolism_Homo sapiens_hsa006200.90450752
75Alzheimers disease_Homo sapiens_hsa050100.89861253
76Long-term depression_Homo sapiens_hsa047300.89267536
77Oxytocin signaling pathway_Homo sapiens_hsa049210.89202648
78Synaptic vesicle cycle_Homo sapiens_hsa047210.87828572
79Biosynthesis of amino acids_Homo sapiens_hsa012300.87378059
80Herpes simplex infection_Homo sapiens_hsa051680.86065101
81Circadian entrainment_Homo sapiens_hsa047130.84080012
82Sulfur metabolism_Homo sapiens_hsa009200.83870073
83PPAR signaling pathway_Homo sapiens_hsa033200.82673805
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.82047860
85Systemic lupus erythematosus_Homo sapiens_hsa053220.81559453
86Renin secretion_Homo sapiens_hsa049240.80630042
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80579743
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79610805
89N-Glycan biosynthesis_Homo sapiens_hsa005100.79451115
90Antigen processing and presentation_Homo sapiens_hsa046120.76984059
91Epstein-Barr virus infection_Homo sapiens_hsa051690.76749836
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75826278
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75449605
94Carbon metabolism_Homo sapiens_hsa012000.74961000
95Phototransduction_Homo sapiens_hsa047440.71639767
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.69916895
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69175298
98Glutathione metabolism_Homo sapiens_hsa004800.68349706
99VEGF signaling pathway_Homo sapiens_hsa043700.68092116
100Rap1 signaling pathway_Homo sapiens_hsa040150.67961552
101Gastric acid secretion_Homo sapiens_hsa049710.67919923
102Choline metabolism in cancer_Homo sapiens_hsa052310.67211792
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65965351
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.61851986
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61358466
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59949286
107Tyrosine metabolism_Homo sapiens_hsa003500.59941414
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59231379
109Bile secretion_Homo sapiens_hsa049760.59157834
110Metabolic pathways_Homo sapiens_hsa011000.57904663
111Fatty acid biosynthesis_Homo sapiens_hsa000610.57838071
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57200958
113Chemokine signaling pathway_Homo sapiens_hsa040620.56321915
114Viral carcinogenesis_Homo sapiens_hsa052030.54845363
115Insulin resistance_Homo sapiens_hsa049310.50780849
116Arginine biosynthesis_Homo sapiens_hsa002200.49012919
117Legionellosis_Homo sapiens_hsa051340.48909526
118Chemical carcinogenesis_Homo sapiens_hsa052040.47777435
119Hedgehog signaling pathway_Homo sapiens_hsa043400.47253178
120Butanoate metabolism_Homo sapiens_hsa006500.45258948
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.44759426
122Hematopoietic cell lineage_Homo sapiens_hsa046400.44208879
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44148224
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44046988
125Morphine addiction_Homo sapiens_hsa050320.44036434
126Olfactory transduction_Homo sapiens_hsa047400.43395484
127GABAergic synapse_Homo sapiens_hsa047270.42980291
128Adherens junction_Homo sapiens_hsa045200.42878131
129Oocyte meiosis_Homo sapiens_hsa041140.42643768
130Cardiac muscle contraction_Homo sapiens_hsa042600.42510180
131Inositol phosphate metabolism_Homo sapiens_hsa005620.41666981
132Ras signaling pathway_Homo sapiens_hsa040140.41178046
133GnRH signaling pathway_Homo sapiens_hsa049120.40955804
134cAMP signaling pathway_Homo sapiens_hsa040240.40291438
135Small cell lung cancer_Homo sapiens_hsa052220.39916088
136Fatty acid degradation_Homo sapiens_hsa000710.39731378
137Propanoate metabolism_Homo sapiens_hsa006400.39655881
138Salivary secretion_Homo sapiens_hsa049700.38976338
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38335227
140Arginine and proline metabolism_Homo sapiens_hsa003300.34756131
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33653508
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32618319
143Protein digestion and absorption_Homo sapiens_hsa049740.31644810
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31160470
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29721708
146Alcoholism_Homo sapiens_hsa050340.28124667
147Apoptosis_Homo sapiens_hsa042100.26416419
148Peroxisome_Homo sapiens_hsa041460.25687745
149HTLV-I infection_Homo sapiens_hsa051660.24123340
150ECM-receptor interaction_Homo sapiens_hsa045120.23244870
151Vitamin digestion and absorption_Homo sapiens_hsa049770.22336368
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20839175
153Sphingolipid metabolism_Homo sapiens_hsa006000.20232801
154ABC transporters_Homo sapiens_hsa020100.18807990
155Hepatitis B_Homo sapiens_hsa051610.18606494
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18182434
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18094987
158Thyroid cancer_Homo sapiens_hsa052160.18058685
159Fatty acid metabolism_Homo sapiens_hsa012120.17420612
160Linoleic acid metabolism_Homo sapiens_hsa005910.14465894
161Measles_Homo sapiens_hsa051620.13612406
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13203788
163alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11990339
164Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11288856
165Bladder cancer_Homo sapiens_hsa052190.09266332
166Influenza A_Homo sapiens_hsa051640.07357846
167Lysine degradation_Homo sapiens_hsa003100.05787202
168Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05426557
169Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04715437
170Acute myeloid leukemia_Homo sapiens_hsa052210.02965111
171Galactose metabolism_Homo sapiens_hsa000520.02806100
172beta-Alanine metabolism_Homo sapiens_hsa004100.02408872
173Fat digestion and absorption_Homo sapiens_hsa049750.01887641
174Adipocytokine signaling pathway_Homo sapiens_hsa049200.00906173
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0026897

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