PRSS41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.65548304
2establishment of integrated proviral latency (GO:0075713)4.63134894
3formation of translation preinitiation complex (GO:0001731)4.28607678
4pseudouridine synthesis (GO:0001522)4.27542563
5folic acid-containing compound biosynthetic process (GO:0009396)4.19666979
6ribosomal small subunit assembly (GO:0000028)4.08855208
7ribosome biogenesis (GO:0042254)4.05099706
8IMP biosynthetic process (GO:0006188)4.00809577
9maturation of SSU-rRNA (GO:0030490)3.97500285
10regulation of posttranscriptional gene silencing (GO:0060147)3.96509416
11regulation of gene silencing by miRNA (GO:0060964)3.96509416
12regulation of gene silencing by RNA (GO:0060966)3.96509416
13nucleobase biosynthetic process (GO:0046112)3.89935313
14positive regulation of response to oxidative stress (GO:1902884)3.75848898
15positive regulation of cellular response to oxidative stress (GO:1900409)3.75848898
16mitotic metaphase plate congression (GO:0007080)3.75409690
17kinetochore assembly (GO:0051382)3.73931957
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71739931
19purine nucleobase biosynthetic process (GO:0009113)3.66059545
20chromatin remodeling at centromere (GO:0031055)3.65092041
21DNA replication initiation (GO:0006270)3.64749779
22regulation of helicase activity (GO:0051095)3.62513346
23proteasome assembly (GO:0043248)3.60812370
24CENP-A containing nucleosome assembly (GO:0034080)3.60732111
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.60509468
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60509468
27DNA strand elongation involved in DNA replication (GO:0006271)3.58160229
28regulation of mitochondrial translation (GO:0070129)3.57782040
29DNA replication-dependent nucleosome assembly (GO:0006335)3.56605695
30DNA replication-dependent nucleosome organization (GO:0034723)3.56605695
31ribonucleoprotein complex biogenesis (GO:0022613)3.56142528
32kinetochore organization (GO:0051383)3.51750775
33histone arginine methylation (GO:0034969)3.49692017
34ribosomal large subunit biogenesis (GO:0042273)3.48715643
35daunorubicin metabolic process (GO:0044597)3.47401400
36polyketide metabolic process (GO:0030638)3.47401400
37doxorubicin metabolic process (GO:0044598)3.47401400
38maturation of 5.8S rRNA (GO:0000460)3.46926195
39metaphase plate congression (GO:0051310)3.44854917
40DNA replication checkpoint (GO:0000076)3.42773584
41rRNA modification (GO:0000154)3.39618825
42establishment of viral latency (GO:0019043)3.35517767
43spliceosomal complex assembly (GO:0000245)3.34782216
44DNA strand elongation (GO:0022616)3.32591916
45peptidyl-arginine omega-N-methylation (GO:0035247)3.31604519
46telomere maintenance via semi-conservative replication (GO:0032201)3.29229358
47ribosome assembly (GO:0042255)3.24540819
48base-excision repair, AP site formation (GO:0006285)3.21495662
49telomere maintenance via recombination (GO:0000722)3.19901943
50IMP metabolic process (GO:0046040)3.15568591
51rRNA processing (GO:0006364)3.15512471
52spliceosomal snRNP assembly (GO:0000387)3.13085880
53DNA unwinding involved in DNA replication (GO:0006268)3.11392529
54rRNA metabolic process (GO:0016072)3.08405113
55translational termination (GO:0006415)3.07819240
56viral transcription (GO:0019083)3.04959577
57pteridine-containing compound biosynthetic process (GO:0042559)3.04589262
58DNA replication-independent nucleosome assembly (GO:0006336)3.02262227
59DNA replication-independent nucleosome organization (GO:0034724)3.02262227
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.01807141
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01807141
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01807141
63regulation of cardioblast proliferation (GO:0003264)3.01091628
64regulation of secondary heart field cardioblast proliferation (GO:0003266)3.01091628
65translational initiation (GO:0006413)3.01090248
66histone exchange (GO:0043486)3.00873684
67viral mRNA export from host cell nucleus (GO:0046784)2.98432550
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.98171026
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97635136
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.96387696
71termination of RNA polymerase III transcription (GO:0006386)2.96387696
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93838780
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93546603
74non-recombinational repair (GO:0000726)2.93011175
75double-strand break repair via nonhomologous end joining (GO:0006303)2.93011175
76translation (GO:0006412)2.92590893
77establishment of chromosome localization (GO:0051303)2.92590884
78positive regulation of chromosome segregation (GO:0051984)2.90246898
79nuclear pore organization (GO:0006999)2.89302626
80mitotic recombination (GO:0006312)2.89031427
81cellular component biogenesis (GO:0044085)2.86570222
82cotranslational protein targeting to membrane (GO:0006613)2.85937109
83oxidative phosphorylation (GO:0006119)2.85919671
84transcription-coupled nucleotide-excision repair (GO:0006283)2.85789394
85translational elongation (GO:0006414)2.85686888
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.85218574
87protein targeting to ER (GO:0045047)2.83765963
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.82905263
89protein localization to chromosome, centromeric region (GO:0071459)2.81912846
90protein complex localization (GO:0031503)2.81198666
91L-methionine salvage (GO:0071267)2.79610403
92L-methionine biosynthetic process (GO:0071265)2.79610403
93amino acid salvage (GO:0043102)2.79610403
94DNA double-strand break processing (GO:0000729)2.77582055
95mitotic sister chromatid segregation (GO:0000070)2.77545849
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.77025901
97isotype switching (GO:0045190)2.76829866
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76829866
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76829866
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76784102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25341546
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49356790
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62510798
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.48196093
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18383000
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07402458
7MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07323723
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.02945931
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91016403
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87940909
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.81397131
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.81192456
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.61252583
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.60884008
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.60884008
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.60884008
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59276509
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56081101
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.50062888
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45310784
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.40855757
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33626330
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31065904
24XRN2_22483619_ChIP-Seq_HELA_Human2.23618516
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20584520
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19635361
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.14205066
28SOX2_18555785_ChIP-Seq_MESCs_Mouse2.13901144
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08592156
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05188443
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.03520092
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02131708
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00405600
34VDR_23849224_ChIP-Seq_CD4+_Human1.98929449
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98854975
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98608046
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96278656
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94615117
39TTF2_22483619_ChIP-Seq_HELA_Human1.94376632
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.93422428
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89937006
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89874629
43AR_21909140_ChIP-Seq_LNCAP_Human1.88687945
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84981610
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84021318
46DCP1A_22483619_ChIP-Seq_HELA_Human1.77784190
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75672899
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74410027
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73392169
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66457164
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63279817
52FOXP3_21729870_ChIP-Seq_TREG_Human1.62423780
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61629365
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60555414
55GABP_19822575_ChIP-Seq_HepG2_Human1.59992306
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59134215
57NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.57786379
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55379561
59ELK1_19687146_ChIP-ChIP_HELA_Human1.54459342
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50126877
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47913301
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42509673
63KDM5A_27292631_Chip-Seq_BREAST_Human1.40846295
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39485241
65SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38322999
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37672540
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.34413460
68IRF1_19129219_ChIP-ChIP_H3396_Human1.32131189
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28428062
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.27979995
71CIITA_25753668_ChIP-Seq_RAJI_Human1.23269979
72POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22841878
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21902296
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19269095
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18579406
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18363133
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18066093
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17519970
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16421503
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15541021
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14424158
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13778838
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07349625
84NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06679238
85TFEB_21752829_ChIP-Seq_HELA_Human1.06571392
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04059683
87MYC_18940864_ChIP-ChIP_HL60_Human1.00722519
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.96944269
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96115593
90KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95965978
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94681286
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.94284077
93SALL1_21062744_ChIP-ChIP_HESCs_Human0.94176124
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93804832
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.93744540
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91858285
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88978367
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88089939
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87624702
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87037957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.88622339
2MP0004957_abnormal_blastocyst_morpholog4.29660556
3MP0005499_abnormal_olfactory_system4.07732032
4MP0005394_taste/olfaction_phenotype4.07732032
5MP0008789_abnormal_olfactory_epithelium3.70107749
6MP0003806_abnormal_nucleotide_metabolis3.42238541
7MP0010094_abnormal_chromosome_stability3.37350210
8MP0003111_abnormal_nucleus_morphology3.26675026
9MP0003077_abnormal_cell_cycle3.09835950
10MP0008877_abnormal_DNA_methylation3.06716297
11MP0008058_abnormal_DNA_repair2.90457633
12MP0006292_abnormal_olfactory_placode2.86720253
13MP0003123_paternal_imprinting2.77944199
14MP0002653_abnormal_ependyma_morphology2.74616241
15MP0003183_abnormal_peptide_metabolism2.70960736
16MP0003718_maternal_effect2.50463469
17MP0008932_abnormal_embryonic_tissue2.28957416
18MP0000678_abnormal_parathyroid_gland2.28734773
19MP0004133_heterotaxia2.27319050
20MP0003136_yellow_coat_color2.11212752
21MP0010030_abnormal_orbit_morphology2.02187089
22MP0008057_abnormal_DNA_replication1.82168089
23MP0001293_anophthalmia1.81399392
24MP0010352_gastrointestinal_tract_polyps1.78560947
25MP0006072_abnormal_retinal_apoptosis1.73349337
26MP0001730_embryonic_growth_arrest1.73262550
27MP0003283_abnormal_digestive_organ1.64181145
28MP0000350_abnormal_cell_proliferation1.59527058
29MP0003786_premature_aging1.52243614
30MP0003119_abnormal_digestive_system1.52043029
31MP0001984_abnormal_olfaction1.47348957
32MP0002085_abnormal_embryonic_tissue1.41833502
33MP0008007_abnormal_cellular_replicative1.39903045
34MP0005377_hearing/vestibular/ear_phenot1.38527275
35MP0003878_abnormal_ear_physiology1.38527275
36MP0001697_abnormal_embryo_size1.38095372
37MP0005380_embryogenesis_phenotype1.37869009
38MP0001672_abnormal_embryogenesis/_devel1.37869009
39MP0003787_abnormal_imprinting1.37625115
40MP0003890_abnormal_embryonic-extraembry1.34978349
41MP0000490_abnormal_crypts_of1.30805725
42MP0004197_abnormal_fetal_growth/weight/1.26892716
43MP0000049_abnormal_middle_ear1.25991949
44MP0002084_abnormal_developmental_patter1.24238296
45MP0003186_abnormal_redox_activity1.24091100
46MP0002080_prenatal_lethality1.20817950
47MP0002877_abnormal_melanocyte_morpholog1.20312337
48MP0003121_genomic_imprinting1.20099585
49MP0000613_abnormal_salivary_gland1.15488387
50MP0003984_embryonic_growth_retardation1.12991329
51MP0002233_abnormal_nose_morphology1.12117630
52MP0002088_abnormal_embryonic_growth/wei1.10701850
53MP0002086_abnormal_extraembryonic_tissu1.09818942
54MP0000313_abnormal_cell_death1.01829834
55MP0005084_abnormal_gallbladder_morpholo1.01504334
56MP0002160_abnormal_reproductive_system0.99140272
57MP0001188_hyperpigmentation0.97223672
58MP0001286_abnormal_eye_development0.96932551
59MP0002210_abnormal_sex_determination0.96343714
60MP0009672_abnormal_birth_weight0.94155529
61MP0002751_abnormal_autonomic_nervous0.93918788
62MP0001145_abnormal_male_reproductive0.92858864
63MP0009703_decreased_birth_body0.92464206
64MP0002277_abnormal_respiratory_mucosa0.91551948
65MP0003122_maternal_imprinting0.90795789
66MP0001348_abnormal_lacrimal_gland0.84573901
67MP0003567_abnormal_fetal_cardiomyocyte0.83234105
68MP0004233_abnormal_muscle_weight0.82805442
69MP0001929_abnormal_gametogenesis0.82400401
70MP0005395_other_phenotype0.80114352
71MP0000631_abnormal_neuroendocrine_gland0.78969747
72MP0002693_abnormal_pancreas_physiology0.78060458
73MP0002127_abnormal_cardiovascular_syste0.77079721
74MP0002697_abnormal_eye_size0.74226849
75MP0000653_abnormal_sex_gland0.73680663
76MP0005266_abnormal_metabolism0.73669581
77MP0003942_abnormal_urinary_system0.73530730
78MP0010307_abnormal_tumor_latency0.72677610
79MP0000462_abnormal_digestive_system0.71794933
80MP0009379_abnormal_foot_pigmentation0.71288955
81MP0005389_reproductive_system_phenotype0.70103354
82MP0002111_abnormal_tail_morphology0.69887452
83MP0002249_abnormal_larynx_morphology0.67959002
84MP0003861_abnormal_nervous_system0.66598784
85MP0001485_abnormal_pinna_reflex0.64551045
86MP0001986_abnormal_taste_sensitivity0.64384308
87MP0002019_abnormal_tumor_incidence0.60890417
88MP0003938_abnormal_ear_development0.60128738
89MP0000534_abnormal_ureter_morphology0.59760249
90MP0005410_abnormal_fertilization0.59288751
91MP0002138_abnormal_hepatobiliary_system0.59043437
92MP0001853_heart_inflammation0.58422850
93MP0005391_vision/eye_phenotype0.58348923
94MP0002092_abnormal_eye_morphology0.57974470
95MP0003698_abnormal_male_reproductive0.55867390
96MP0000358_abnormal_cell_content/0.55286672
97MP0005174_abnormal_tail_pigmentation0.54424855
98MP0006036_abnormal_mitochondrial_physio0.53768213
99MP0004264_abnormal_extraembryonic_tissu0.51552160
100MP0001919_abnormal_reproductive_system0.51084301

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)5.03833547
2Degeneration of anterior horn cells (HP:0002398)5.03833547
3Selective tooth agenesis (HP:0001592)4.04163888
4Birth length less than 3rd percentile (HP:0003561)4.01403380
5Colon cancer (HP:0003003)3.97613892
6Supernumerary spleens (HP:0009799)3.49649729
7Stenosis of the external auditory canal (HP:0000402)3.47960149
8Oral leukoplakia (HP:0002745)3.47655129
9Ependymoma (HP:0002888)3.42437645
10Agnosia (HP:0010524)3.35794933
11Abnormal number of incisors (HP:0011064)3.35328876
12Medulloblastoma (HP:0002885)3.24392409
13Premature graying of hair (HP:0002216)3.15924495
14Rhabdomyosarcoma (HP:0002859)3.13008881
15Intestinal atresia (HP:0011100)3.06577497
16Breast hypoplasia (HP:0003187)3.06170551
17Abnormality of the renal collecting system (HP:0004742)3.02154631
18Abnormality of cochlea (HP:0000375)2.97357810
19Rough bone trabeculation (HP:0100670)2.93428721
20Cerebral hypomyelination (HP:0006808)2.91926746
21Aplastic anemia (HP:0001915)2.91721027
22Atrophy/Degeneration involving motor neurons (HP:0007373)2.84811603
23Abnormality of the labia minora (HP:0012880)2.80675426
24Lip pit (HP:0100267)2.68950134
25Missing ribs (HP:0000921)2.65180377
26Asplenia (HP:0001746)2.63721326
27Reticulocytopenia (HP:0001896)2.63543115
28Abnormal lung lobation (HP:0002101)2.54501145
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.51188935
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51188935
31Rib fusion (HP:0000902)2.48743282
32Impulsivity (HP:0100710)2.46206781
33Abnormal trabecular bone morphology (HP:0100671)2.36095430
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.35711909
35Osteomalacia (HP:0002749)2.34339498
36Meckel diverticulum (HP:0002245)2.34263947
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.31254536
38Abnormality of the astrocytes (HP:0100707)2.28931361
39Astrocytoma (HP:0009592)2.28931361
40Pseudobulbar signs (HP:0002200)2.25382112
41Abnormality of the ileum (HP:0001549)2.25290735
42Secondary amenorrhea (HP:0000869)2.23481519
43Absent radius (HP:0003974)2.22696631
44Glioma (HP:0009733)2.19994195
45Abnormality of the preputium (HP:0100587)2.19015719
46Carpal bone hypoplasia (HP:0001498)2.18299684
4711 pairs of ribs (HP:0000878)2.17531790
48Rectal fistula (HP:0100590)2.16451109
49Rectovaginal fistula (HP:0000143)2.16451109
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.15318878
51Cellular immunodeficiency (HP:0005374)2.15140484
52Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14838344
53Abnormality of chromosome stability (HP:0003220)2.13387432
54Absent thumb (HP:0009777)2.11500558
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10025958
56Morphological abnormality of the inner ear (HP:0011390)2.09685653
57Increased hepatocellular lipid droplets (HP:0006565)2.07018742
58Abnormality of the corticospinal tract (HP:0002492)2.05156734
59Abnormality of cells of the erythroid lineage (HP:0012130)2.04718266
60Neoplasm of striated muscle (HP:0009728)2.02102742
61Gastrointestinal atresia (HP:0002589)2.00772094
62Absent forearm bone (HP:0003953)2.00096473
63Aplasia involving forearm bones (HP:0009822)2.00096473
64Aplasia/Hypoplasia of the patella (HP:0006498)1.99846775
65Microvesicular hepatic steatosis (HP:0001414)1.99698939
66Patellar aplasia (HP:0006443)1.99273232
67Chromsome breakage (HP:0040012)1.97985435
68Facial cleft (HP:0002006)1.94100911
69Horseshoe kidney (HP:0000085)1.93973012
70Basal cell carcinoma (HP:0002671)1.93927412
71Neoplasm of the pancreas (HP:0002894)1.92606901
72Biliary tract neoplasm (HP:0100574)1.92333178
73Abdominal situs inversus (HP:0003363)1.91301547
74Abnormality of abdominal situs (HP:0011620)1.91301547
75Bone marrow hypocellularity (HP:0005528)1.91078320
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.91035787
77Microretrognathia (HP:0000308)1.90066329
78Septo-optic dysplasia (HP:0100842)1.89016095
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88238735
80Tracheoesophageal fistula (HP:0002575)1.88204769
81Widely patent fontanelles and sutures (HP:0004492)1.87114039
82Esophageal atresia (HP:0002032)1.85842914
83Macrocytic anemia (HP:0001972)1.85010075
84Trismus (HP:0000211)1.83718306
85Abnormality of the duodenum (HP:0002246)1.82510256
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78665438
87Lipid accumulation in hepatocytes (HP:0006561)1.78188393
88Prominent metopic ridge (HP:0005487)1.77171240
89Abnormal number of erythroid precursors (HP:0012131)1.76792100
90Abnormality of the lower motor neuron (HP:0002366)1.75423849
91Neoplasm of the oral cavity (HP:0100649)1.74982059
92Duodenal stenosis (HP:0100867)1.74425983
93Small intestinal stenosis (HP:0012848)1.74425983
94Abnormal neuron morphology (HP:0012757)1.74416831
95Abnormality of the motor neurons (HP:0002450)1.74416831
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73369493
97Amaurosis fugax (HP:0100576)1.72496374
98Optic nerve hypoplasia (HP:0000609)1.72186469
99Intestinal fistula (HP:0100819)1.71335772
100Vertebral clefting (HP:0008428)1.70876472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.72741973
2EPHA23.93889578
3EIF2AK13.39961212
4WEE13.23073049
5CDC73.19246217
6PASK2.48540275
7TLK12.29815539
8EIF2AK32.25086960
9TTK2.16616187
10SRPK12.15113991
11MAP3K112.10823717
12PRKD32.10344415
13TESK22.01085159
14RPS6KB21.95205349
15TAOK21.93072637
16PBK1.83092408
17TSSK61.81349889
18PNCK1.77063976
19STK161.75672589
20MKNK11.67576054
21FLT31.60416052
22BRD41.58851940
23NEK11.55456257
24PRKCI1.51038207
25CDK121.49503942
26RPS6KA41.47878901
27STK38L1.45359853
28AKT31.42040676
29AURKA1.40763724
30VRK11.40679305
31PLK41.39555554
32MAP2K31.39244225
33YES11.38295131
34PLK11.32068465
35MKNK21.28950294
36MAP2K61.28709816
37CDK71.26209850
38ATR1.23519859
39ALK1.22619536
40TESK11.20589743
41AURKB1.17234028
42NEK21.16773739
43CHEK11.10119248
44WNK31.09264106
45MAP3K81.08870056
46MAPK151.06316625
47ZAK1.03962299
48UHMK11.02299648
49PAK41.01566523
50TAOK11.01105561
51PLK31.00944977
52CHEK21.00047793
53MET0.97458093
54CSNK2A20.93587516
55BRAF0.89671664
56DYRK30.86692217
57SCYL20.84963116
58PIM10.76068564
59MST40.72152394
60STK40.71708441
61CDK20.69357699
62MAP3K30.68939016
63PIK3CG0.65823119
64ATM0.63691924
65FGFR10.59665848
66CDK190.59415455
67DYRK20.59414399
68STK380.56451671
69CSNK2A10.56373530
70CSNK1E0.55312917
71MAP2K20.53412095
72ADRBK20.48486594
73CDK10.46997956
74RIPK10.43506825
75PAK10.42886408
76PRKDC0.38785260
77NEK60.35379235
78RPS6KA50.33788395
79DAPK10.32925464
80BCKDK0.32166654
81AKT20.30297921
82NLK0.26945594
83PDK20.25837508
84MAPK140.25382425
85IRAK30.23364982
86ARAF0.23139466
87CDK40.22838853
88PDK40.22180011
89PDK30.22180011
90NTRK10.21902667
91PRKCG0.21901219
92GSK3B0.21610725
93CAMK2G0.21337694
94CAMK40.20984136
95EIF2AK20.20621777
96CLK10.18240151
97CSNK1D0.16717411
98FRK0.15428505
99AKT10.14756526
100MAPK100.14425718

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.25881840
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.91651459
3DNA replication_Homo sapiens_hsa030303.91035063
4Ribosome_Homo sapiens_hsa030103.54135479
5Spliceosome_Homo sapiens_hsa030403.39819978
6RNA polymerase_Homo sapiens_hsa030203.27533476
7Proteasome_Homo sapiens_hsa030503.25454915
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00177848
9One carbon pool by folate_Homo sapiens_hsa006702.99576087
10RNA transport_Homo sapiens_hsa030132.87419196
11Base excision repair_Homo sapiens_hsa034102.43807836
12Homologous recombination_Homo sapiens_hsa034402.37196911
13Pyrimidine metabolism_Homo sapiens_hsa002402.19488555
14Sulfur metabolism_Homo sapiens_hsa009202.14167879
15Fanconi anemia pathway_Homo sapiens_hsa034602.12383002
16Nucleotide excision repair_Homo sapiens_hsa034202.10362260
17Protein export_Homo sapiens_hsa030601.97305153
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.94970076
19Cell cycle_Homo sapiens_hsa041101.93430964
20Sulfur relay system_Homo sapiens_hsa041221.86339988
21Basal transcription factors_Homo sapiens_hsa030221.81146544
22Non-homologous end-joining_Homo sapiens_hsa034501.79250638
23mRNA surveillance pathway_Homo sapiens_hsa030151.78636157
24RNA degradation_Homo sapiens_hsa030181.67775330
25Selenocompound metabolism_Homo sapiens_hsa004501.66610347
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58138914
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.57758212
28Folate biosynthesis_Homo sapiens_hsa007901.56778811
29Oxidative phosphorylation_Homo sapiens_hsa001901.38375147
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30420146
31Huntingtons disease_Homo sapiens_hsa050161.25670413
32Purine metabolism_Homo sapiens_hsa002301.25609970
33Parkinsons disease_Homo sapiens_hsa050121.18610176
34Galactose metabolism_Homo sapiens_hsa000521.15905144
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11301356
36Glutathione metabolism_Homo sapiens_hsa004801.10337301
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03257668
38Fructose and mannose metabolism_Homo sapiens_hsa000511.03232827
39p53 signaling pathway_Homo sapiens_hsa041151.02080299
40Vibrio cholerae infection_Homo sapiens_hsa051100.94453605
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94226420
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93285260
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92866096
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.90814179
45Epstein-Barr virus infection_Homo sapiens_hsa051690.87035302
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80315230
47Thyroid cancer_Homo sapiens_hsa052160.74269524
48Oocyte meiosis_Homo sapiens_hsa041140.67023082
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62669423
50Biosynthesis of amino acids_Homo sapiens_hsa012300.62170463
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55730101
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54351552
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51647057
54Alzheimers disease_Homo sapiens_hsa050100.49291389
55Butanoate metabolism_Homo sapiens_hsa006500.48562221
56Chemical carcinogenesis_Homo sapiens_hsa052040.47713645
57Systemic lupus erythematosus_Homo sapiens_hsa053220.45216284
58Pentose phosphate pathway_Homo sapiens_hsa000300.43914192
59Metabolic pathways_Homo sapiens_hsa011000.41928464
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40469800
61Alcoholism_Homo sapiens_hsa050340.39702295
62Viral carcinogenesis_Homo sapiens_hsa052030.37709164
63Vitamin B6 metabolism_Homo sapiens_hsa007500.37269931
64Basal cell carcinoma_Homo sapiens_hsa052170.35973877
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34308415
66Hedgehog signaling pathway_Homo sapiens_hsa043400.34168466
67Hippo signaling pathway_Homo sapiens_hsa043900.32345977
68Other glycan degradation_Homo sapiens_hsa005110.32302861
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32247469
70Arginine and proline metabolism_Homo sapiens_hsa003300.30309014
71Shigellosis_Homo sapiens_hsa051310.29647300
72Type I diabetes mellitus_Homo sapiens_hsa049400.29634447
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27676644
74Collecting duct acid secretion_Homo sapiens_hsa049660.26913573
75Herpes simplex infection_Homo sapiens_hsa051680.26367368
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25315606
77Notch signaling pathway_Homo sapiens_hsa043300.24848993
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23908127
79Carbon metabolism_Homo sapiens_hsa012000.23579787
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22852307
81Linoleic acid metabolism_Homo sapiens_hsa005910.20738308
82HTLV-I infection_Homo sapiens_hsa051660.20249368
83Tight junction_Homo sapiens_hsa045300.20227829
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19741402
85Antigen processing and presentation_Homo sapiens_hsa046120.18106402
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15255857
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15236399
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13444767
89N-Glycan biosynthesis_Homo sapiens_hsa005100.12461642
90Arachidonic acid metabolism_Homo sapiens_hsa005900.11427776
91Phenylalanine metabolism_Homo sapiens_hsa003600.10730187
92Renin-angiotensin system_Homo sapiens_hsa046140.09680483
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08809460
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.08370831
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.05323502
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04895135
97Cardiac muscle contraction_Homo sapiens_hsa042600.04248201
98Melanoma_Homo sapiens_hsa052180.04100216
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03646473
100Synaptic vesicle cycle_Homo sapiens_hsa047210.02837722

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