PRSS35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)9.90175920
2regulation of male gonad development (GO:2000018)9.16821665
3cellular response to cadmium ion (GO:0071276)9.01914979
4sex determination (GO:0007530)8.80421695
5response to follicle-stimulating hormone (GO:0032354)8.31115659
6glucocorticoid metabolic process (GO:0008211)7.98016399
7androgen metabolic process (GO:0008209)7.49764125
8regulation of gonadotropin secretion (GO:0032276)7.40305314
9C21-steroid hormone metabolic process (GO:0008207)7.37852479
10estrogen metabolic process (GO:0008210)7.28535312
11progesterone metabolic process (GO:0042448)7.15026853
12hormone biosynthetic process (GO:0042446)7.06598767
13cellular response to interferon-alpha (GO:0035457)6.64257552
14ketone biosynthetic process (GO:0042181)6.44674766
15cellular response to gonadotropin stimulus (GO:0071371)6.34813314
16Leydig cell differentiation (GO:0033327)6.20653007
17negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.93132622
18cellular response to antibiotic (GO:0071236)5.82402914
19regulation of female gonad development (GO:2000194)5.45121702
20adhesion of symbiont to host (GO:0044406)5.14608468
21negative regulation of macrophage differentiation (GO:0045650)4.83569927
22male sex determination (GO:0030238)4.80224235
23response to gonadotropin (GO:0034698)4.75442939
24cardiac muscle cell development (GO:0055013)4.74156586
25atrial septum morphogenesis (GO:0060413)4.67241665
26cardiac myofibril assembly (GO:0055003)4.59666171
27negative regulation of striated muscle cell apoptotic process (GO:0010664)4.56007920
28sex differentiation (GO:0007548)4.46949302
29cardiac cell development (GO:0055006)4.42966102
30cellular response to growth hormone stimulus (GO:0071378)4.33968918
31ventricular cardiac muscle cell development (GO:0055015)4.31162790
32anatomical structure regression (GO:0060033)4.30883528
33mating behavior (GO:0007617)4.26667549
34cardiac chamber formation (GO:0003207)4.23764660
35myofibril assembly (GO:0030239)4.22734199
36cellular response to toxic substance (GO:0097237)4.18423815
37response to leptin (GO:0044321)4.10197523
38regulation of the force of heart contraction (GO:0002026)4.10068953
39sarcomere organization (GO:0045214)4.06097119
40outflow tract septum morphogenesis (GO:0003148)4.04315711
41renal system process involved in regulation of blood volume (GO:0001977)4.01628394
42response to BMP (GO:0071772)3.99194746
43cellular response to BMP stimulus (GO:0071773)3.99194746
44oocyte development (GO:0048599)3.95245861
45positive regulation of cardiac muscle cell proliferation (GO:0060045)3.94872172
46male genitalia development (GO:0030539)3.86952153
47glomerular basement membrane development (GO:0032836)3.84958314
48hemoglobin metabolic process (GO:0020027)3.80521042
49protein heterotrimerization (GO:0070208)3.78561589
50regulation of actin filament-based movement (GO:1903115)3.77996303
51positive regulation of cardiac muscle tissue development (GO:0055025)3.77413422
52G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.75041575
53positive regulation of reproductive process (GO:2000243)3.74514697
54cardiac ventricle formation (GO:0003211)3.66394332
55female gonad development (GO:0008585)3.64406019
56positive regulation of cardiac muscle tissue growth (GO:0055023)3.63255957
57cardiac muscle hypertrophy (GO:0003300)3.62552519
58paraxial mesoderm development (GO:0048339)3.61974528
59response to insecticide (GO:0017085)3.61482198
60seminiferous tubule development (GO:0072520)3.60123782
61regulation of cardiac muscle cell apoptotic process (GO:0010665)3.58193551
62regulation of cardiac muscle tissue development (GO:0055024)3.55770940
63adult heart development (GO:0007512)3.55755502
64actin-myosin filament sliding (GO:0033275)3.54101720
65muscle filament sliding (GO:0030049)3.54101720
66regulation of meiosis I (GO:0060631)3.49493548
67positive regulation of heart growth (GO:0060421)3.48344095
68adrenal gland development (GO:0030325)3.47855162
69regulation of cardiac muscle cell contraction (GO:0086004)3.45410192
70cardiac muscle tissue morphogenesis (GO:0055008)3.42058079
71striated muscle hypertrophy (GO:0014897)3.40622724
72cell migration involved in heart development (GO:0060973)3.38480156
73ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.34402752
74response to lead ion (GO:0010288)3.33960971
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31162493
76regulation of striated muscle cell apoptotic process (GO:0010662)3.30578951
77notochord development (GO:0030903)3.30070048
78mesenchymal cell proliferation (GO:0010463)3.26684106
79regulation of cardiac muscle cell proliferation (GO:0060043)3.24606588
80cellular hormone metabolic process (GO:0034754)3.24184943
81peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.23627933
82phagocytosis, recognition (GO:0006910)3.20445975
83male gonad development (GO:0008584)3.19503024
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.19195751
85regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.19115949
86dorsal/ventral axis specification (GO:0009950)3.18635849
87planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18563510
88neuron projection extension involved in neuron projection guidance (GO:1902284)3.17871183
89axon extension involved in axon guidance (GO:0048846)3.17871183
90ovulation cycle (GO:0042698)3.17645402
91muscle tissue morphogenesis (GO:0060415)3.16436587
92actin-mediated cell contraction (GO:0070252)3.16294869
93mesenchyme morphogenesis (GO:0072132)3.15055404
94bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14594214
95anterior/posterior axis specification, embryo (GO:0008595)3.14562807
96regulation of cardiac muscle cell differentiation (GO:2000725)3.13613106
97cell communication by electrical coupling (GO:0010644)3.09105460
98cardiac muscle tissue development (GO:0048738)3.08606335
99negative regulation of hormone biosynthetic process (GO:0032353)3.08335843
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08070778
101endocardial cushion morphogenesis (GO:0003203)3.03383041
102cell migration involved in gastrulation (GO:0042074)3.02957882
103regulation of heart growth (GO:0060420)3.02360953
104cardiac septum development (GO:0003279)3.01159554
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97748085
106response to phenylpropanoid (GO:0080184)2.95613637
107gonad development (GO:0008406)2.94934261
108toxin metabolic process (GO:0009404)2.94870838
109cardiac muscle contraction (GO:0060048)2.94124553
110fusion of sperm to egg plasma membrane (GO:0007342)2.94033782
111regulation of cardiac muscle tissue growth (GO:0055021)2.93293241
112ovulation cycle process (GO:0022602)2.92023216
113positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.91305788
114cardiac muscle hypertrophy in response to stress (GO:0014898)2.90656689
115muscle hypertrophy in response to stress (GO:0003299)2.90656689
116cardiac muscle adaptation (GO:0014887)2.90656689
117response to vitamin E (GO:0033197)2.90256491
118reproductive system development (GO:0061458)2.89514059
119cellular response to zinc ion (GO:0071294)2.89210934
120muscle hypertrophy (GO:0014896)2.88896104
121epithelial cell-cell adhesion (GO:0090136)2.87231104
122regulation of mesoderm development (GO:2000380)2.87093403
123actomyosin structure organization (GO:0031032)2.87054231
124regulation of transforming growth factor beta2 production (GO:0032909)2.86991082
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.85359296
126extracellular negative regulation of signal transduction (GO:1900116)2.85276022
127extracellular regulation of signal transduction (GO:1900115)2.85276022
128positive regulation of SMAD protein import into nucleus (GO:0060391)2.84503716
129anterior/posterior axis specification (GO:0009948)2.84360481
130heart morphogenesis (GO:0003007)2.83931830
131endoderm formation (GO:0001706)2.82123115
132cardiac septum morphogenesis (GO:0060411)2.81464911
133regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.80981792
134positive regulation of cardiac muscle cell differentiation (GO:2000727)2.79434646
135ovarian follicle development (GO:0001541)2.79323373
136regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79306593
137embryonic digestive tract morphogenesis (GO:0048557)2.78940231
138piRNA metabolic process (GO:0034587)2.77382890
139mesenchymal cell differentiation (GO:0048762)2.76763726
140cytokine metabolic process (GO:0042107)2.75340028
141relaxation of cardiac muscle (GO:0055119)2.75267034
142maintenance of protein location in nucleus (GO:0051457)2.74807137
143head development (GO:0060322)2.74582642
144negative regulation of embryonic development (GO:0045992)2.74348297
145regulation of steroid biosynthetic process (GO:0050810)2.73584924
146embryonic heart tube development (GO:0035050)2.73111378
147muscle cell fate commitment (GO:0042693)2.72775442
148positive regulation of muscle organ development (GO:0048636)2.72736939
149positive regulation of striated muscle tissue development (GO:0045844)2.72736939
150regulation of secondary heart field cardioblast proliferation (GO:0003266)2.72727684
151regulation of cardioblast proliferation (GO:0003264)2.72727684
152collagen fibril organization (GO:0030199)2.72378560
153negative regulation of chondrocyte differentiation (GO:0032331)2.71609426
154urogenital system development (GO:0001655)2.71145438
155response to interferon-alpha (GO:0035455)2.67837343
156basement membrane organization (GO:0071711)2.65980224
157benzene-containing compound metabolic process (GO:0042537)2.65126701
158steroid biosynthetic process (GO:0006694)2.61527138
159vitamin D metabolic process (GO:0042359)2.61297321
160glomerulus development (GO:0032835)2.61191422
161cellular ketone metabolic process (GO:0042180)2.61145228
162genitalia development (GO:0048806)2.60669446
163atrioventricular valve morphogenesis (GO:0003181)2.59867190
164receptor guanylyl cyclase signaling pathway (GO:0007168)2.59640977
165apoptotic cell clearance (GO:0043277)2.58319683
166bone trabecula formation (GO:0060346)2.58030432
167low-density lipoprotein particle clearance (GO:0034383)2.56689160
168cellular response to epinephrine stimulus (GO:0071872)2.56248232
169negative regulation of reproductive process (GO:2000242)2.55775057
170multicellular organismal aging (GO:0010259)2.54987748
171regulation of steroid hormone biosynthetic process (GO:0090030)2.51519667
172chondrocyte development (GO:0002063)2.49870650
173positive regulation of nitric-oxide synthase activity (GO:0051000)2.47475263
174embryonic foregut morphogenesis (GO:0048617)2.45939212
175endocardial cushion development (GO:0003197)2.44745021
176synaptonemal complex assembly (GO:0007130)2.41389063
177response to corticosterone (GO:0051412)2.40008691
178regulation of cardioblast differentiation (GO:0051890)2.39563195
179collagen catabolic process (GO:0030574)2.34738513
180regulation of glomerular filtration (GO:0003093)2.32188677
181collagen metabolic process (GO:0032963)2.27200623
182vagina development (GO:0060068)2.27190929
183fibroblast migration (GO:0010761)2.25432911
184female genitalia development (GO:0030540)2.23432130
185positive regulation of meiosis (GO:0045836)2.21989968
186sequestering of extracellular ligand from receptor (GO:0035581)2.20878641
187estrogen biosynthetic process (GO:0006703)15.8138631
188androgen biosynthetic process (GO:0006702)14.4517396
189gonadal mesoderm development (GO:0007506)14.0586701
190C21-steroid hormone biosynthetic process (GO:0006700)11.3037417
191glucocorticoid biosynthetic process (GO:0006704)10.4873744
192cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.4241916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.47905455
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.98983321
3HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.39154183
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36950410
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.27109323
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.27109323
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.27109323
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.19846198
9CLOCK_20551151_ChIP-Seq_293T_Human3.04970461
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.82184538
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.80025685
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.70712397
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.45472218
14EZH2_22144423_ChIP-Seq_EOC_Human2.34733347
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20781426
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.19595967
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.19348402
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12675702
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12141790
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10389561
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07167340
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03945088
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95593785
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.93184340
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90494617
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90494617
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.88950309
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.88886200
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.84210673
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79212893
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76138460
32P300_19829295_ChIP-Seq_ESCs_Human1.75533479
33EWS_26573619_Chip-Seq_HEK293_Human1.74112079
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71711300
35TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.70666048
36FUS_26573619_Chip-Seq_HEK293_Human1.69224694
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65129832
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64816574
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.63300526
40SMAD4_21741376_ChIP-Seq_HESCs_Human1.62250797
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61763388
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57845260
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56500732
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53575457
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.53193098
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52913160
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51522096
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51203566
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.48829207
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.47583454
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.47427654
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47185919
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47170748
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46948937
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46856872
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.44888108
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40691231
58GBX2_23144817_ChIP-Seq_PC3_Human1.40487576
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40408717
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39966800
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39350285
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39215626
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38931008
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38928060
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36850984
66KDM2B_26808549_Chip-Seq_K562_Human1.36656537
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35787503
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.35440692
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35192293
70TAF15_26573619_Chip-Seq_HEK293_Human1.34845975
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.34801207
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33196887
73TP53_18474530_ChIP-ChIP_U2OS_Human1.29554163
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29299330
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27454678
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27438075
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27438075
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27146229
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26855134
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25505168
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25010189
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.24754552
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24633344
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24315040
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23073574
86SMAD4_21799915_ChIP-Seq_A2780_Human1.22684512
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22561260
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22494359
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21703908
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21612805
91EOMES_21245162_ChIP-Seq_HESCs_Human1.21183679
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19922320
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19520707
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19113729
95CJUN_26792858_Chip-Seq_BT549_Human1.18969686
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18446709
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17224091
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16667347
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16109842
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14693412
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14601764
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14487562
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.14073037
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12444531
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.12409215
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12364839
107RNF2_27304074_Chip-Seq_NSC_Mouse1.11983920
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11643981
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10702894
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.10511103
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10492449
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09833356
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.08820462
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08656865
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.08567879
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08039131
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08022258
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07631976
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.07349003
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07331790
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.06758258
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06155437
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.05517556
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05348755
125SOX9_26525672_Chip-Seq_HEART_Mouse1.05181678
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04310830
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03160442
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03156848
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02891935
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.02490180
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01729621
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01166464
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.01070887
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00819555
135* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98768290
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.98677111
137TP53_22127205_ChIP-Seq_IMR90_Human0.98406276
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93125327
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91764277
140BRD4_25478319_ChIP-Seq_HGPS_Human0.91675494
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91248468
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.91061873
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.87701932
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.87188402
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.86821050
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.86681185
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86439659
148AHR_22903824_ChIP-Seq_MCF-7_Human0.86374361
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.85872712
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83765593
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83715025
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83715025
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.82374841
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.82374841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.36768895
2MP0000639_abnormal_adrenal_gland3.96960075
3MP0003195_calcinosis3.96647672
4MP0008438_abnormal_cutaneous_collagen3.84057522
5MP0005503_abnormal_tendon_morphology3.65998646
6MP0005647_abnormal_sex_gland3.34836189
7MP0009384_cardiac_valve_regurgitation3.29950050
8MP0010030_abnormal_orbit_morphology3.26646117
9MP0002909_abnormal_adrenal_gland3.21813617
10MP0003878_abnormal_ear_physiology2.96583004
11MP0005377_hearing/vestibular/ear_phenot2.96583004
12MP0003315_abnormal_perineum_morphology2.94302180
13MP0003890_abnormal_embryonic-extraembry2.90910815
14MP0001661_extended_life_span2.77100757
15MP0004272_abnormal_basement_membrane2.67334706
16MP0002837_dystrophic_cardiac_calcinosis2.48139042
17MP0001958_emphysema2.38746532
18MP0008877_abnormal_DNA_methylation2.37634139
19MP0005623_abnormal_meninges_morphology2.29518919
20MP0004215_abnormal_myocardial_fiber2.09664093
21MP0003937_abnormal_limbs/digits/tail_de2.01826009
22MP0003786_premature_aging1.98094217
23MP0002160_abnormal_reproductive_system1.92696725
24MP0005275_abnormal_skin_tensile1.91591027
25MP0005389_reproductive_system_phenotype1.87453661
26MP0003941_abnormal_skin_development1.85306439
27MP0008775_abnormal_heart_ventricle1.83385800
28MP0002210_abnormal_sex_determination1.80364902
29MP0003045_fibrosis1.74076669
30MP0002168_other_aberrant_phenotype1.68245439
31MP0003137_abnormal_impulse_conducting1.67136165
32MP0003123_paternal_imprinting1.66663626
33MP0001919_abnormal_reproductive_system1.65650269
34MP0001145_abnormal_male_reproductive1.61141860
35MP0002102_abnormal_ear_morphology1.60623001
36MP0002697_abnormal_eye_size1.57289934
37MP0005330_cardiomyopathy1.54804183
38MP0001293_anophthalmia1.54708215
39MP0009278_abnormal_bone_marrow1.54358236
40MP0002127_abnormal_cardiovascular_syste1.53043326
41MP0004134_abnormal_chest_morphology1.52830593
42MP0002972_abnormal_cardiac_muscle1.51890765
43MP0002896_abnormal_bone_mineralization1.51241221
44MP0003936_abnormal_reproductive_system1.49666054
45MP0000751_myopathy1.46153772
46MP0000653_abnormal_sex_gland1.41989612
47MP0003115_abnormal_respiratory_system1.40414879
48MP0003136_yellow_coat_color1.40340496
49MP0004084_abnormal_cardiac_muscle1.40152711
50MP0005508_abnormal_skeleton_morphology1.38764294
51MP0010630_abnormal_cardiac_muscle1.38247880
52MP0000462_abnormal_digestive_system1.38063869
53MP0004085_abnormal_heartbeat1.37904270
54MP0003279_aneurysm1.37221606
55MP0001286_abnormal_eye_development1.36421669
56MP0009250_abnormal_appendicular_skeleto1.36295297
57MP0000516_abnormal_urinary_system1.35688897
58MP0005367_renal/urinary_system_phenotyp1.35688897
59MP0005257_abnormal_intraocular_pressure1.34655665
60MP0002282_abnormal_trachea_morphology1.32971058
61MP0003122_maternal_imprinting1.32315105
62MP0001542_abnormal_bone_strength1.31516562
63MP0001299_abnormal_eye_distance/1.30682026
64MP0003942_abnormal_urinary_system1.30169601
65MP0001119_abnormal_female_reproductive1.30048492
66MP0005620_abnormal_muscle_contractility1.28669194
67MP0004858_abnormal_nervous_system1.28457709
68MP0005248_abnormal_Harderian_gland1.27675609
69MP0003283_abnormal_digestive_organ1.27393345
70MP0000631_abnormal_neuroendocrine_gland1.26451644
71MP0001929_abnormal_gametogenesis1.23234475
72MP0002115_abnormal_skeleton_extremities1.22803123
73MP0002249_abnormal_larynx_morphology1.20718879
74MP0002108_abnormal_muscle_morphology1.19370505
75MP0002938_white_spotting1.17927091
76MP0002234_abnormal_pharynx_morphology1.16899439
77MP0002084_abnormal_developmental_patter1.10974255
78MP0009053_abnormal_anal_canal1.10485589
79MP0003121_genomic_imprinting1.09604065
80MP0006138_congestive_heart_failure1.08724582
81MP0006054_spinal_hemorrhage1.08028532
82MP0003385_abnormal_body_wall1.07828666
83MP0010368_abnormal_lymphatic_system1.07487946
84MP0003935_abnormal_craniofacial_develop1.04938040
85MP0003091_abnormal_cell_migration1.04915983
86MP0003119_abnormal_digestive_system1.04915208
87MP0000428_abnormal_craniofacial_morphol1.04572617
88MP0000537_abnormal_urethra_morphology1.03307343
89MP0002111_abnormal_tail_morphology1.03188418
90MP0001544_abnormal_cardiovascular_syste1.02344802
91MP0005385_cardiovascular_system_phenoty1.02344802
92MP0004883_abnormal_blood_vessel1.02100853
93MP0000163_abnormal_cartilage_morphology0.99682036
94MP0004087_abnormal_muscle_fiber0.98773335
95MP0005171_absent_coat_pigmentation0.97896518
96MP0002295_abnormal_pulmonary_circulatio0.97373212
97MP0006292_abnormal_olfactory_placode0.96640386
98MP0003787_abnormal_imprinting0.96293098
99MP0002085_abnormal_embryonic_tissue0.94903189
100MP0003755_abnormal_palate_morphology0.94185597
101MP0002092_abnormal_eye_morphology0.93934835
102MP0003984_embryonic_growth_retardation0.92286430
103MP0009780_abnormal_chondrocyte_physiolo0.92115093
104MP0005380_embryogenesis_phenotype0.91188643
105MP0001672_abnormal_embryogenesis/_devel0.91188643
106MP0005187_abnormal_penis_morphology0.90643334
107MP0002088_abnormal_embryonic_growth/wei0.89985624
108MP0000566_synostosis0.88727296
109MP0002109_abnormal_limb_morphology0.87447907
110MP0006072_abnormal_retinal_apoptosis0.86878695
111MP0000266_abnormal_heart_morphology0.86741090
112MP0002233_abnormal_nose_morphology0.86426805
113MP0000432_abnormal_head_morphology0.85462960
114MP0002116_abnormal_craniofacial_bone0.84595124
115MP0002128_abnormal_blood_circulation0.82511903
116MP0005369_muscle_phenotype0.82471108
117MP0002751_abnormal_autonomic_nervous0.81747770
118MP0002653_abnormal_ependyma_morphology0.81052040
119MP0000049_abnormal_middle_ear0.80698320
120MP0003705_abnormal_hypodermis_morpholog0.80317383
121MP0005395_other_phenotype0.79951650
122MP0005197_abnormal_uvea_morphology0.79919478
123MP0005076_abnormal_cell_differentiation0.79548015
124MP0002925_abnormal_cardiovascular_devel0.79095119
125MP0004197_abnormal_fetal_growth/weight/0.79063586
126MP0000749_muscle_degeneration0.78388094
127MP0004036_abnormal_muscle_relaxation0.78382010
128MP0000778_abnormal_nervous_system0.77694579
129MP0003950_abnormal_plasma_membrane0.77531400
130MP0003698_abnormal_male_reproductive0.77045024
131MP0003566_abnormal_cell_adhesion0.76594053
132MP0002113_abnormal_skeleton_development0.76241682
133MP0005391_vision/eye_phenotype0.76006367
134MP0008932_abnormal_embryonic_tissue0.75424602
135MP0002009_preneoplasia0.74633553
136MP0003879_abnormal_hair_cell0.74279302
137MP0003567_abnormal_fetal_cardiomyocyte0.73534283
138MP0002114_abnormal_axial_skeleton0.71962495
139MP0001340_abnormal_eyelid_morphology0.71636937
140MP0000762_abnormal_tongue_morphology0.71108997
141MP0002932_abnormal_joint_morphology0.66524835
142MP0004145_abnormal_muscle_electrophysio0.66459528
143MP0000538_abnormal_urinary_bladder0.66332837
144MP0004233_abnormal_muscle_weight0.66198738
145MP0002998_abnormal_bone_remodeling0.64995028
146MP0001765_abnormal_ion_homeostasis0.64516391
147MP0003699_abnormal_female_reproductive0.64202404
148MP0000767_abnormal_smooth_muscle0.63776060
149MP0003795_abnormal_bone_structure0.62610718
150MP0003953_abnormal_hormone_level0.62544279
151MP0001270_distended_abdomen0.62343489
152MP0004147_increased_porphyrin_level0.62129264
153MP0000534_abnormal_ureter_morphology0.59311684

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)8.96789605
2Sex reversal (HP:0012245)8.96789605
3Gonadotropin excess (HP:0000837)7.97197149
4Gonadal dysgenesis (HP:0000133)7.92041573
5Renal salt wasting (HP:0000127)5.54610268
6Male pseudohermaphroditism (HP:0000037)5.38270575
7Testicular neoplasm (HP:0010788)5.35527047
8Male infertility (HP:0003251)4.81735420
9Enlarged penis (HP:0000040)4.55638099
10Azoospermia (HP:0000027)4.41269774
11Hypoplasia of the uterus (HP:0000013)4.34119357
12Ankle contracture (HP:0006466)4.13831639
13Metaphyseal cupping (HP:0003021)3.97138180
14Protrusio acetabuli (HP:0003179)3.92795091
15Ventricular tachycardia (HP:0004756)3.50734649
16Atrial fibrillation (HP:0005110)3.48712173
17Aplasia/hypoplasia of the uterus (HP:0008684)3.37479105
18Premature ovarian failure (HP:0008209)3.36705555
19Bilateral microphthalmos (HP:0007633)3.26213656
20Patent foramen ovale (HP:0001655)3.23467339
21Secondary amenorrhea (HP:0000869)3.20795665
22Neonatal short-limb short stature (HP:0008921)3.19453602
23Abnormal spermatogenesis (HP:0008669)3.16024672
24Hyperpituitarism (HP:0010514)3.09760055
25Abnormality of male internal genitalia (HP:0000022)3.08548967
26Premature rupture of membranes (HP:0001788)3.03544857
27Double outlet right ventricle (HP:0001719)3.03269775
28Congenital malformation of the right heart (HP:0011723)3.03269775
29Hyperaldosteronism (HP:0000859)2.98204519
30Abnormal ventriculo-arterial connection (HP:0011563)2.98095711
31Transposition of the great arteries (HP:0001669)2.98095711
32Abnormal connection of the cardiac segments (HP:0011545)2.98095711
33Primary atrial arrhythmia (HP:0001692)2.95433017
34Cutaneous finger syndactyly (HP:0010554)2.91422996
35Hip contracture (HP:0003273)2.90096514
36Supraventricular arrhythmia (HP:0005115)2.85246294
37Limited hip movement (HP:0008800)2.81887842
38Supraventricular tachycardia (HP:0004755)2.81761895
39Bladder diverticulum (HP:0000015)2.79780915
40Lipoatrophy (HP:0100578)2.74971141
41Follicular hyperkeratosis (HP:0007502)2.74659679
42Cutaneous syndactyly (HP:0012725)2.67750428
43Midline defect of the nose (HP:0004122)2.66451228
44Bifid tongue (HP:0010297)2.62737608
45Abnormality of dentin (HP:0010299)2.60521077
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58443152
47Short 4th metacarpal (HP:0010044)2.58443152
48Abnormal pancreas size (HP:0012094)2.57823908
49Mitral valve prolapse (HP:0001634)2.56587616
50Vascular tortuosity (HP:0004948)2.54515543
51Preaxial foot polydactyly (HP:0001841)2.52463791
52Germ cell neoplasia (HP:0100728)2.52053112
53Cupped ribs (HP:0000887)2.51663207
54Right ventricular cardiomyopathy (HP:0011663)2.48813181
55Rectal prolapse (HP:0002035)2.46558887
56Infertility (HP:0000789)2.44454939
57Vitreoretinal degeneration (HP:0000655)2.43243766
58Hypoplastic ischia (HP:0003175)2.43025273
59Pulmonary fibrosis (HP:0002206)2.38827723
60Hypoplastic left heart (HP:0004383)2.38677792
61Infantile muscular hypotonia (HP:0008947)2.37368281
62Arterial tortuosity (HP:0005116)2.37115465
63Abnormal lung lobation (HP:0002101)2.33944655
64Lymphangioma (HP:0100764)2.33793940
65Orthostatic hypotension (HP:0001278)2.31929572
66Anophthalmia (HP:0000528)2.30539233
67Periauricular skin pits (HP:0100277)2.26650738
68Preauricular pit (HP:0004467)2.26650738
69Partial duplication of thumb phalanx (HP:0009944)2.26441578
70Sudden death (HP:0001699)2.25158082
71Septo-optic dysplasia (HP:0100842)2.24487109
72Breech presentation (HP:0001623)2.23202742
73Broad metatarsal (HP:0001783)2.22933006
74Epiphyseal dysplasia (HP:0002656)2.21243755
75Partial duplication of the phalanx of hand (HP:0009999)2.21166681
76Peritonitis (HP:0002586)2.19968212
77Cerebral aneurysm (HP:0004944)2.19940534
78Abnormality of the calf musculature (HP:0001430)2.17958462
79Abnormality of the fetal cardiovascular system (HP:0010948)2.17743509
80Abnormal umbilical cord blood vessels (HP:0011403)2.17743509
81Single umbilical artery (HP:0001195)2.17743509
82Abnormality of the ischium (HP:0003174)2.17225470
83Wormian bones (HP:0002645)2.15436384
84Morphological abnormality of the middle ear (HP:0008609)2.14805132
85Aortic dissection (HP:0002647)2.14363042
86Selective tooth agenesis (HP:0001592)2.13487117
87Increased circulating renin level (HP:0000848)2.10347646
88Dilatation of the ascending aorta (HP:0005111)2.08957198
89Abnormality of the aortic arch (HP:0012303)2.08778309
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.08669008
91Soft skin (HP:0000977)2.08176779
92Aortic aneurysm (HP:0004942)2.05617954
93Abnormality of the 4th metacarpal (HP:0010012)2.04036623
94Atrophic scars (HP:0001075)2.02753959
95Arachnodactyly (HP:0001166)2.01966932
96Myelomeningocele (HP:0002475)2.01489574
97Bundle branch block (HP:0011710)2.00708417
98Bowel diverticulosis (HP:0005222)2.00254736
99Dilated cardiomyopathy (HP:0001644)1.99694718
100Hypoventilation (HP:0002791)1.98597437
101Mild short stature (HP:0003502)1.97113320
102Abnormality of the parietal bone (HP:0002696)1.96922753
103Irregular epiphyses (HP:0010582)1.95125960
104Vertebral clefting (HP:0008428)1.94593406
105Ectopia lentis (HP:0001083)1.94322070
106Subaortic stenosis (HP:0001682)1.93594135
107Abnormality of the left ventricular outflow tract (HP:0011103)1.93594135
108Abnormality of the pubic bones (HP:0003172)1.92152061
109Hand muscle atrophy (HP:0009130)1.91085790
110Absent frontal sinuses (HP:0002688)1.90946890
111Menstrual irregularities (HP:0000858)1.90608611
112Congenital diaphragmatic hernia (HP:0000776)1.90312939
113Renal hypoplasia (HP:0000089)1.90062057
114Primary amenorrhea (HP:0000786)1.89430464
115Sprengel anomaly (HP:0000912)1.88719243
116Shallow orbits (HP:0000586)1.87383236
117Calcaneovalgus deformity (HP:0001848)1.86791287
118Turricephaly (HP:0000262)1.86564543
119Ovarian neoplasm (HP:0100615)1.85277486
120Mesangial abnormality (HP:0001966)1.85192900
121Short middle phalanx of the 5th finger (HP:0004220)1.84324675
122Maternal diabetes (HP:0009800)1.84274539
123Mesomelia (HP:0003027)1.83106404
124Inguinal hernia (HP:0000023)1.82978594
125Coronal craniosynostosis (HP:0004440)1.82520628
126Choanal stenosis (HP:0000452)1.82077184
127Decreased circulating renin level (HP:0003351)1.82002417
128Hyperextensible skin (HP:0000974)1.81874267
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81798136
130Tongue fasciculations (HP:0001308)1.79927147
131Skin pits (HP:0100276)1.78998111
132Increased corneal curvature (HP:0100692)1.78868618
133Keratoconus (HP:0000563)1.78868618
134Type 1 muscle fiber predominance (HP:0003803)1.77205847
135Broad alveolar ridges (HP:0000187)1.75992326
136Coxa vara (HP:0002812)1.75970755
137Blue sclerae (HP:0000592)1.75141847
138Abnormal delivery (HP:0001787)1.74611842
139Broad long bones (HP:0005622)1.74535779
140Thin ribs (HP:0000883)1.74066733
14111 pairs of ribs (HP:0000878)1.72322844
142Abnormality of renin-angiotensin system (HP:0000847)1.71955402
143Abnormality of the phalanges of the 5th finger (HP:0004213)1.71635050
144Mixed hearing impairment (HP:0000410)1.71522421
145Platyspondyly (HP:0000926)1.71231615
146Abnormal tarsal ossification (HP:0008369)1.70678587
147Exostoses (HP:0100777)1.70391645
148Delayed epiphyseal ossification (HP:0002663)1.69733638
149Spinal rigidity (HP:0003306)1.69327975
150Muscle fibrillation (HP:0010546)1.69286292
151Hypoplastic heart (HP:0001961)1.69100109
152Joint laxity (HP:0001388)1.66910013
153Primary adrenal insufficiency (HP:0008207)1.66628445
154Slender build (HP:0001533)1.66294457
155Accelerated skeletal maturation (HP:0005616)1.66166359
156Facial diplegia (HP:0001349)1.64784504
157Osteoarthritis (HP:0002758)1.64271669
158Fibular hypoplasia (HP:0003038)1.63901190
159Renal duplication (HP:0000075)1.63566865
160Short 5th finger (HP:0009237)1.62482863
161Micromelia (HP:0002983)1.61318488
162Decreased skull ossification (HP:0004331)1.61303412
163Broad palm (HP:0001169)1.61246772
164Small epiphyses (HP:0010585)1.59896461
165Macroorchidism (HP:0000053)1.59040174
166Pulmonary artery stenosis (HP:0004415)1.58401271
167Polycystic ovaries (HP:0000147)1.58165213
168Wide anterior fontanel (HP:0000260)1.57758445
169Renovascular hypertension (HP:0100817)1.56340609
170Shawl scrotum (HP:0000049)1.56318112
171Fragile skin (HP:0001030)1.55434491
172Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.55398559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.21310631
2TYRO34.18085401
3LATS14.06961412
4TRIB33.80728813
5CDK123.78774978
6CDK73.59598847
7DDR23.12590153
8TNIK2.89897685
9PLK42.62430006
10OBSCN2.60998271
11PDGFRA2.56952642
12MAP3K102.45023922
13PNCK2.18652383
14STK38L2.18407995
15FER1.94643965
16RIPK11.92138395
17ERBB41.91003023
18BRSK21.90811793
19BMPR1B1.90016550
20LATS21.89804620
21ICK1.87985974
22TRIM281.84517000
23EPHB21.84380280
24PKN21.81137373
25PTK61.80055839
26STK31.79137570
27BRD41.77871970
28MYLK1.77565723
29WEE11.71183347
30FLT31.68138967
31WNK31.67803500
32STK241.66205674
33FGFR11.52902662
34TNK21.47214498
35ERBB31.45473400
36SRPK11.35895188
37TTK1.35557363
38CASK1.31991932
39PAK41.31380351
40SIK11.30291034
41ZAK1.30005657
42MAP3K41.21342442
43CSNK1A1L1.19024734
44CAMK1D1.18309092
45PLK21.16353439
46EPHA41.15667469
47CDC71.13402593
48MST41.11979061
49MTOR1.11280659
50WNK11.10573810
51ACVR1B1.10545405
52CDK41.10022948
53PLK31.09241970
54CAMK1G1.08764569
55STK391.04363837
56PTK21.03089492
57NLK1.00144591
58TGFBR10.99591839
59CDK90.99261119
60PIK3CA0.98610141
61MKNK20.98478345
62NEK90.97224814
63BRSK10.96727590
64ERN10.95524929
65GRK70.94943039
66LRRK20.92157665
67CAMK10.91916166
68PAK30.90993308
69ROCK20.89109746
70PAK20.88960694
71CDC42BPA0.86237718
72SIK30.86027806
73WNK40.86010512
74DAPK30.85257379
75TIE10.84129273
76PRKD30.84094763
77MAPK30.83920536
78DAPK20.83370013
79PIK3CG0.81161189
80BCR0.81081789
81DYRK20.78820474
82MKNK10.77230312
83NUAK10.77069553
84MAPK70.74659167
85TESK10.73043334
86PDK20.71650746
87EPHA30.69451516
88MET0.69382676
89MAPK10.69344588
90LMTK20.69339093
91LIMK10.68702899
92EEF2K0.67614052
93PDGFRB0.67087091
94PBK0.66972896
95FGFR20.65570882
96NME10.62835598
97MAP3K120.62262560
98SGK2230.61011993
99SGK4940.61011993
100PTK2B0.60341078
101VRK20.59889279
102SGK20.59694110
103ROCK10.58147079
104PAK10.56958050
105DYRK1A0.56249357
106PKN10.55298181
107TGFBR20.51934799
108SGK30.51690446
109BMX0.51397613
110EPHA20.51060141
111VRK10.50418221
112BRAF0.50347220
113TTN0.50170403
114AURKB0.49511749
115EIF2AK30.49361002
116CAMK2A0.48815709
117ADRBK10.47799293
118CSNK1G10.47546340
119CHUK0.47339337
120MAPK120.46253164
121CDK30.45380495
122STK100.44836842
123MAPK140.44628378
124EIF2AK10.44054371
125DMPK0.42556903
126NTRK10.42088516
127DYRK1B0.41989342
128GSK3B0.41696497
129EPHB10.41452347
130GSK3A0.41384338
131MAP3K50.41381151
132AKT10.40297005
133CAMK40.38290525
134CDK10.38033916
135NEK20.37892364
136ILK0.37267094
137PRKACB0.35991973
138PRKCE0.34910979
139KSR10.34543921
140PRKCG0.34337417
141PLK10.33787739
142PASK0.33557589
143STK380.33375583
144ERBB20.33325457
145CHEK10.33236680
146RET0.31537489
147PRKDC0.31444147
148MATK0.30442254
149CHEK20.28946942
150INSR0.28809364
151NTRK30.28760357
152MAPK80.28737998
153MUSK0.27611471
154CDK60.27219813
155ATM0.27041987
156FGFR40.26693228
157CAMK2D0.25953201
158CSNK1E0.25081677

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049136.77636954
2Steroid hormone biosynthesis_Homo sapiens_hsa001406.64580956
3Aldosterone synthesis and secretion_Homo sapiens_hsa049254.37163834
4ECM-receptor interaction_Homo sapiens_hsa045123.52018339
5Fatty acid biosynthesis_Homo sapiens_hsa000612.96061939
6Cardiac muscle contraction_Homo sapiens_hsa042602.39715853
7Hedgehog signaling pathway_Homo sapiens_hsa043402.37926915
8TGF-beta signaling pathway_Homo sapiens_hsa043502.23874442
9Protein digestion and absorption_Homo sapiens_hsa049742.09181718
10Fatty acid metabolism_Homo sapiens_hsa012122.00208979
11Vitamin digestion and absorption_Homo sapiens_hsa049771.85274074
12Propanoate metabolism_Homo sapiens_hsa006401.82059547
13Focal adhesion_Homo sapiens_hsa045101.81266941
14Mismatch repair_Homo sapiens_hsa034301.72558115
15Basal cell carcinoma_Homo sapiens_hsa052171.65765537
16Steroid biosynthesis_Homo sapiens_hsa001001.62178103
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58557233
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58058976
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55093976
20Protein export_Homo sapiens_hsa030601.48890217
21Hippo signaling pathway_Homo sapiens_hsa043901.44566005
22Amoebiasis_Homo sapiens_hsa051461.39006385
23Small cell lung cancer_Homo sapiens_hsa052221.39000219
24Proteasome_Homo sapiens_hsa030501.36894627
25Lysine degradation_Homo sapiens_hsa003101.29771972
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27357107
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24223689
28Wnt signaling pathway_Homo sapiens_hsa043101.14230822
29Nucleotide excision repair_Homo sapiens_hsa034201.07913937
30Axon guidance_Homo sapiens_hsa043601.06969980
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05912492
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04904354
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03263887
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03191004
35cAMP signaling pathway_Homo sapiens_hsa040241.00668326
36Adherens junction_Homo sapiens_hsa045200.98722355
37Proteoglycans in cancer_Homo sapiens_hsa052050.97881709
38Prostate cancer_Homo sapiens_hsa052150.97660413
39Notch signaling pathway_Homo sapiens_hsa043300.96501224
40Non-homologous end-joining_Homo sapiens_hsa034500.96354099
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93452424
42Renin secretion_Homo sapiens_hsa049240.88952031
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88822389
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88796489
45PPAR signaling pathway_Homo sapiens_hsa033200.87879852
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87876944
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85831918
48Sulfur relay system_Homo sapiens_hsa041220.84404709
49Pyruvate metabolism_Homo sapiens_hsa006200.82750675
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80958099
51Fatty acid degradation_Homo sapiens_hsa000710.78870796
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.76798686
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76555458
54mRNA surveillance pathway_Homo sapiens_hsa030150.76397347
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75341873
56RNA degradation_Homo sapiens_hsa030180.74131858
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72923569
58Glutathione metabolism_Homo sapiens_hsa004800.72655252
59Pathways in cancer_Homo sapiens_hsa052000.72497957
60Parkinsons disease_Homo sapiens_hsa050120.71119394
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71021892
62Dorso-ventral axis formation_Homo sapiens_hsa043200.70176296
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69992566
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69968018
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.69806656
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69369450
67Fatty acid elongation_Homo sapiens_hsa000620.68252413
68Homologous recombination_Homo sapiens_hsa034400.67920238
69Prolactin signaling pathway_Homo sapiens_hsa049170.65660099
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.62994314
71N-Glycan biosynthesis_Homo sapiens_hsa005100.62915105
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62879645
73DNA replication_Homo sapiens_hsa030300.58748540
74Toxoplasmosis_Homo sapiens_hsa051450.58614067
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58311545
76Tight junction_Homo sapiens_hsa045300.58034278
77Carbon metabolism_Homo sapiens_hsa012000.57429102
78Estrogen signaling pathway_Homo sapiens_hsa049150.56680181
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55097128
80Fanconi anemia pathway_Homo sapiens_hsa034600.54715695
81Dilated cardiomyopathy_Homo sapiens_hsa054140.54428852
82Melanogenesis_Homo sapiens_hsa049160.54141091
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53947432
84Thyroid cancer_Homo sapiens_hsa052160.52623091
85Viral myocarditis_Homo sapiens_hsa054160.51410441
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50999367
87Insulin secretion_Homo sapiens_hsa049110.50725558
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50721364
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50663200
90Circadian entrainment_Homo sapiens_hsa047130.49836300
91Mineral absorption_Homo sapiens_hsa049780.49651536
92MicroRNAs in cancer_Homo sapiens_hsa052060.48862338
93p53 signaling pathway_Homo sapiens_hsa041150.48512696
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48450602
95Colorectal cancer_Homo sapiens_hsa052100.48047510
96Caffeine metabolism_Homo sapiens_hsa002320.46723581
97Huntingtons disease_Homo sapiens_hsa050160.46559206
98HTLV-I infection_Homo sapiens_hsa051660.45131175
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.44126779
100Oxidative phosphorylation_Homo sapiens_hsa001900.43865912
101Galactose metabolism_Homo sapiens_hsa000520.43818063
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43294304
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43085466
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42540498
105Endometrial cancer_Homo sapiens_hsa052130.42183723
106Gastric acid secretion_Homo sapiens_hsa049710.42048488
107Ribosome_Homo sapiens_hsa030100.40665108
108Biosynthesis of amino acids_Homo sapiens_hsa012300.40320310
109Fat digestion and absorption_Homo sapiens_hsa049750.40278761
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40162605
111Taste transduction_Homo sapiens_hsa047420.37750688
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.37503571
113Cell cycle_Homo sapiens_hsa041100.35156760
114Rap1 signaling pathway_Homo sapiens_hsa040150.35032012
115Circadian rhythm_Homo sapiens_hsa047100.34302455
116Olfactory transduction_Homo sapiens_hsa047400.33967346
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32874194
118Insulin resistance_Homo sapiens_hsa049310.32334905
119Alzheimers disease_Homo sapiens_hsa050100.31986434
120Folate biosynthesis_Homo sapiens_hsa007900.31422604
121Oocyte meiosis_Homo sapiens_hsa041140.31292137
122Oxytocin signaling pathway_Homo sapiens_hsa049210.31146747
123Pancreatic cancer_Homo sapiens_hsa052120.30511655
124Basal transcription factors_Homo sapiens_hsa030220.29170584
125Arachidonic acid metabolism_Homo sapiens_hsa005900.28130050
126Melanoma_Homo sapiens_hsa052180.27506669
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27025954
128Gap junction_Homo sapiens_hsa045400.26073851
129Chronic myeloid leukemia_Homo sapiens_hsa052200.24587138
130Ras signaling pathway_Homo sapiens_hsa040140.24413210
131Glioma_Homo sapiens_hsa052140.24165293
132RNA transport_Homo sapiens_hsa030130.23679352
133mTOR signaling pathway_Homo sapiens_hsa041500.21644664
134Thyroid hormone synthesis_Homo sapiens_hsa049180.21101705
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21084929
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20289932
137Phagosome_Homo sapiens_hsa041450.20232708
138Sphingolipid metabolism_Homo sapiens_hsa006000.19926066
139ErbB signaling pathway_Homo sapiens_hsa040120.19440569
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.18399689
141Calcium signaling pathway_Homo sapiens_hsa040200.18028848
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.17726981
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16584078
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15152693

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