PRSS30P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.00012766
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.00012766
3tolerance induction (GO:0002507)6.73328013
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.62625071
5signal complex assembly (GO:0007172)5.58996719
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.35223188
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24611023
8cellular response to interleukin-15 (GO:0071350)5.22696001
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.90518841
10antigen processing and presentation of endogenous antigen (GO:0019883)4.82319591
11Arp2/3 complex-mediated actin nucleation (GO:0034314)4.76404043
12negative thymic T cell selection (GO:0045060)4.50879527
13wound healing, spreading of epidermal cells (GO:0035313)4.50777756
14leukocyte aggregation (GO:0070486)4.48421311
15response to interleukin-15 (GO:0070672)4.47104081
16positive regulation of T cell cytokine production (GO:0002726)4.37226317
17synapsis (GO:0007129)4.30196657
18positive regulation of gamma-delta T cell activation (GO:0046645)4.28742509
19negative T cell selection (GO:0043383)4.27772880
20positive thymic T cell selection (GO:0045059)4.22854474
21regulation of B cell receptor signaling pathway (GO:0050855)4.18892692
22negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.15762813
23regulation of natural killer cell mediated immunity (GO:0002715)4.14822848
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.14822848
25piRNA metabolic process (GO:0034587)4.14065282
26neutrophil activation (GO:0042119)4.10118044
27activated T cell proliferation (GO:0050798)4.09608106
28actin nucleation (GO:0045010)4.06457564
29negative regulation of innate immune response (GO:0045824)4.04084292
30regulation of gamma-delta T cell differentiation (GO:0045586)3.91582756
31neutrophil activation involved in immune response (GO:0002283)3.89863230
32tumor necrosis factor-mediated signaling pathway (GO:0033209)3.77039554
33regulation of gamma-delta T cell activation (GO:0046643)3.73108997
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.72454973
35granulocyte activation (GO:0036230)3.67094156
36DNA synthesis involved in DNA repair (GO:0000731)3.65304523
37mitotic cell cycle arrest (GO:0071850)3.63825511
38leukocyte degranulation (GO:0043299)3.61287683
39response to muramyl dipeptide (GO:0032495)3.60364957
40thymic T cell selection (GO:0045061)3.59233114
41peptidyl-threonine dephosphorylation (GO:0035970)3.55808435
42wound healing, spreading of cells (GO:0044319)3.54841384
43regulation of T cell cytokine production (GO:0002724)3.51919519
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.49390878
45male meiosis (GO:0007140)3.48644417
46pyrimidine dimer repair (GO:0006290)3.48016525
47regulation of DNA damage checkpoint (GO:2000001)3.45079372
48mannosylation (GO:0097502)3.43536124
49positive regulation of T cell differentiation in thymus (GO:0033089)3.41289017
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.40194687
51DNA methylation involved in gamete generation (GO:0043046)3.36397359
52phospholipid scrambling (GO:0017121)3.29653035
53regulation of T cell mediated cytotoxicity (GO:0001914)3.28387762
54preassembly of GPI anchor in ER membrane (GO:0016254)3.28045334
55negative regulation of T cell mediated immunity (GO:0002710)3.26476951
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21973849
57T cell receptor signaling pathway (GO:0050852)3.18463943
58positive T cell selection (GO:0043368)3.17871036
59chromosome organization involved in meiosis (GO:0070192)3.12050943
60negative regulation of bone resorption (GO:0045779)3.08729384
61positive regulation of T cell mediated immunity (GO:0002711)3.06145712
62positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05674366
63lymph node development (GO:0048535)3.03381672
64regulation of T cell mediated immunity (GO:0002709)3.01057524
65regulation of cell killing (GO:0031341)3.00863113
66negative regulation of leukocyte mediated immunity (GO:0002704)2.99918196
67natural killer cell activation (GO:0030101)2.98860493
68cellular response to ATP (GO:0071318)2.96481401
69positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.93987193
70cellular defense response (GO:0006968)2.92914143
71positive regulation of natural killer cell mediated immunity (GO:0002717)2.91678708
72antigen receptor-mediated signaling pathway (GO:0050851)2.90502663
73regulation of alpha-beta T cell proliferation (GO:0046640)2.88487258
74T cell selection (GO:0045058)2.87227036
75meiotic nuclear division (GO:0007126)2.86803486
76interferon-gamma secretion (GO:0072643)2.85600466
77mast cell activation (GO:0045576)2.84499749
78male meiosis I (GO:0007141)2.84300797
79adaptation of signaling pathway (GO:0023058)2.83631391
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81412856
81iron-sulfur cluster assembly (GO:0016226)2.79426609
82metallo-sulfur cluster assembly (GO:0031163)2.79426609
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78507784
84regulation of mitotic spindle checkpoint (GO:1903504)2.78507784
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78471371
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75588436
87regulation of mast cell degranulation (GO:0043304)2.74744872
88cardiolipin metabolic process (GO:0032048)2.74048287
89antigen processing and presentation via MHC class Ib (GO:0002475)2.73385494
90regulation of necroptotic process (GO:0060544)2.72784178
91myeloid cell activation involved in immune response (GO:0002275)2.72546948
92T cell migration (GO:0072678)2.70265887
93mast cell activation involved in immune response (GO:0002279)2.68093868
94mast cell degranulation (GO:0043303)2.68093868
95synaptonemal complex assembly (GO:0007130)2.65029736
96GPI anchor biosynthetic process (GO:0006506)2.64373440
97T cell costimulation (GO:0031295)2.62919780
98positive regulation of lymphocyte mediated immunity (GO:0002708)2.62299295
99regulation of lymphocyte mediated immunity (GO:0002706)2.60362511
100positive regulation of interleukin-2 production (GO:0032743)2.59770693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.22731119
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.98365553
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91923839
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.24161860
5RUNX_20019798_ChIP-Seq_JUKART_Human2.86113903
6MAF_26560356_Chip-Seq_TH1_Human2.83288023
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71650125
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.59349344
9MAF_26560356_Chip-Seq_TH2_Human2.59012028
10VDR_21846776_ChIP-Seq_THP-1_Human2.58412993
11UTX_26944678_Chip-Seq_JUKART_Human2.56005658
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55542648
13MYB_26560356_Chip-Seq_TH2_Human2.34995644
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30636527
15RUNX1_22412390_ChIP-Seq_EML_Mouse2.29007423
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27068754
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21912244
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16435782
19MYC_22102868_ChIP-Seq_BL_Human2.12323199
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11063731
21* P68_20966046_ChIP-Seq_HELA_Human2.04510144
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98351040
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97764968
24SPI1_23547873_ChIP-Seq_NB4_Human1.97751551
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.96983108
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96109674
27MYB_26560356_Chip-Seq_TH1_Human1.92765558
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91253052
29GATA3_27048872_Chip-Seq_THYMUS_Human1.89958312
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89111668
31VDR_24763502_ChIP-Seq_THP-1_Human1.88243627
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88144800
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84728985
34* BCL6_27268052_Chip-Seq_Bcells_Human1.84424250
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84371185
36TCF7_22412390_ChIP-Seq_EML_Mouse1.79219098
37* BCOR_27268052_Chip-Seq_Bcells_Human1.78293206
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.73235971
39LXR_22292898_ChIP-Seq_THP-1_Human1.71495454
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70997072
41E2F1_20622854_ChIP-Seq_HELA_Human1.70033602
42KDM2B_26808549_Chip-Seq_DND41_Human1.67941027
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64944439
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63295094
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.60637567
46* PHF8_20622854_ChIP-Seq_HELA_Human1.57227706
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55252117
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54206770
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53132654
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52342102
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.51099796
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.50929476
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46801163
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46302600
55SCL_19346495_ChIP-Seq_HPC-7_Human1.44171805
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43843799
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43509950
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42612971
59GATA3_26560356_Chip-Seq_TH2_Human1.41128445
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38998961
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38954579
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38431541
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37308372
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36959820
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36843486
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36045264
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35985215
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27901370
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27361957
70P300_27268052_Chip-Seq_Bcells_Human1.26687386
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25512651
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25203664
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23438548
74* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19787924
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19449285
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18156895
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17835704
78ETS1_21867929_ChIP-Seq_TH2_Mouse1.17554530
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17266862
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16262240
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.16093188
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.15814722
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.13317857
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12925112
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11841419
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11140396
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10114060
88SPI1_23127762_ChIP-Seq_K562_Human1.09605320
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.08385429
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08042531
91* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06077098
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05129549
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04815794
94GATA1_22025678_ChIP-Seq_K562_Human1.03341348
95SPI1_20517297_ChIP-Seq_HL60_Human1.00332357
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00256497
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95864189
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94300285
99NCOR1_26117541_ChIP-Seq_K562_Human0.94023982
100* ERA_21632823_ChIP-Seq_H3396_Human0.92595602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.08716846
2MP0005671_abnormal_response_to3.99870288
3MP0008877_abnormal_DNA_methylation3.97157917
4MP0003436_decreased_susceptibility_to3.80408998
5MP0003763_abnormal_thymus_physiology3.71338791
6MP0000685_abnormal_immune_system2.93050315
7MP0001800_abnormal_humoral_immune2.86461571
8MP0005000_abnormal_immune_tolerance2.82475656
9MP0001835_abnormal_antigen_presentation2.78480947
10MP0002723_abnormal_immune_serum2.63336063
11MP0001819_abnormal_immune_cell2.43872391
12MP0002420_abnormal_adaptive_immunity2.38039961
13MP0002452_abnormal_antigen_presenting2.34478940
14MP0001986_abnormal_taste_sensitivity2.21435562
15MP0002398_abnormal_bone_marrow2.15437049
16MP0001790_abnormal_immune_system2.10924176
17MP0005387_immune_system_phenotype2.10924176
18MP0009333_abnormal_splenocyte_physiolog2.05956813
19MP0002419_abnormal_innate_immunity2.04796170
20MP0005025_abnormal_response_to2.04470306
21MP0003828_pulmonary_edema2.04087819
22MP0000465_gastrointestinal_hemorrhage2.02766653
23MP0001919_abnormal_reproductive_system1.96941884
24MP0000703_abnormal_thymus_morphology1.90797775
25MP0000716_abnormal_immune_system1.90244873
26MP0002877_abnormal_melanocyte_morpholog1.90127796
27MP0002405_respiratory_system_inflammati1.86851807
28MP0001533_abnormal_skeleton_physiology1.85848967
29MP0002722_abnormal_immune_system1.83234536
30MP0001661_extended_life_span1.83195279
31MP0000689_abnormal_spleen_morphology1.79433638
32MP0005075_abnormal_melanosome_morpholog1.72814244
33MP0002148_abnormal_hypersensitivity_rea1.72087201
34MP0000015_abnormal_ear_pigmentation1.67617566
35MP0002396_abnormal_hematopoietic_system1.63095997
36MP0003300_gastrointestinal_ulcer1.58506390
37MP0002429_abnormal_blood_cell1.58247975
38MP0005464_abnormal_platelet_physiology1.57667571
39MP0006082_CNS_inflammation1.50938379
40MP0009785_altered_susceptibility_to1.49446837
41MP0002166_altered_tumor_susceptibility1.48557948
42MP0004947_skin_inflammation1.48233797
43MP0001845_abnormal_inflammatory_respons1.45014169
44MP0005389_reproductive_system_phenotype1.42267586
45MP0002009_preneoplasia1.42018340
46MP0004185_abnormal_adipocyte_glucose1.40163107
47MP0004381_abnormal_hair_follicle1.39246381
48MP0004130_abnormal_muscle_cell1.38773232
49MP0004043_abnormal_pH_regulation1.25614695
50MP0002102_abnormal_ear_morphology1.21840160
51MP0002933_joint_inflammation1.20456192
52MP0003866_abnormal_defecation1.20359421
53MP0005058_abnormal_lysosome_morphology1.20250464
54MP0010155_abnormal_intestine_physiology1.20081174
55MP0005257_abnormal_intraocular_pressure1.15462452
56MP0005174_abnormal_tail_pigmentation1.14560096
57MP0005171_absent_coat_pigmentation1.14047051
58MP0005310_abnormal_salivary_gland1.12892405
59MP0008057_abnormal_DNA_replication1.08986444
60MP0003878_abnormal_ear_physiology1.08265273
61MP0005377_hearing/vestibular/ear_phenot1.08265273
62MP0005076_abnormal_cell_differentiation1.04508605
63MP0008469_abnormal_protein_level1.01813553
64MP0003656_abnormal_erythrocyte_physiolo1.00265230
65MP0000858_altered_metastatic_potential0.99426974
66MP0000003_abnormal_adipose_tissue0.95234784
67MP0003943_abnormal_hepatobiliary_system0.95072490
68MP0000013_abnormal_adipose_tissue0.92312818
69MP0002006_tumorigenesis0.90065781
70MP0004264_abnormal_extraembryonic_tissu0.86848249
71MP0002928_abnormal_bile_duct0.86606849
72MP0005670_abnormal_white_adipose0.80774084
73MP0006035_abnormal_mitochondrial_morpho0.80711731
74MP0004147_increased_porphyrin_level0.80417930
75MP0001851_eye_inflammation0.79355130
76MP0001968_abnormal_touch/_nociception0.79318121
77MP0002019_abnormal_tumor_incidence0.78632735
78MP0009278_abnormal_bone_marrow0.78273864
79MP0003880_abnormal_central_pattern0.75174418
80MP0002998_abnormal_bone_remodeling0.73069683
81MP0003786_premature_aging0.70698407
82MP0003795_abnormal_bone_structure0.69568292
83MP0001765_abnormal_ion_homeostasis0.69550499
84MP0001873_stomach_inflammation0.69503490
85MP0002160_abnormal_reproductive_system0.68756266
86MP0001545_abnormal_hematopoietic_system0.66963824
87MP0005397_hematopoietic_system_phenotyp0.66963824
88MP0005390_skeleton_phenotype0.65411348
89MP0001929_abnormal_gametogenesis0.64973223
90MP0003787_abnormal_imprinting0.63959914
91MP0006072_abnormal_retinal_apoptosis0.63428967
92MP0009764_decreased_sensitivity_to0.63379616
93MP0003303_peritoneal_inflammation0.63333669
94MP0008995_early_reproductive_senescence0.58679710
95MP0003448_altered_tumor_morphology0.57731436
96MP0001119_abnormal_female_reproductive0.57333808
97MP0009765_abnormal_xenobiotic_induced0.57325348
98MP0002210_abnormal_sex_determination0.56913678
99MP0003329_amyloid_beta_deposits0.56880124
100MP0003111_abnormal_nucleus_morphology0.55692835

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.80867793
2Anteriorly placed anus (HP:0001545)4.71668031
3IgG deficiency (HP:0004315)4.63366190
4Eczematoid dermatitis (HP:0000976)4.37387314
5T lymphocytopenia (HP:0005403)4.35955648
6Abnormality of T cells (HP:0002843)3.90260288
7Abnormality of T cell number (HP:0011839)3.81459584
8Increased IgM level (HP:0003496)3.51830422
9IgM deficiency (HP:0002850)3.44536110
10Myositis (HP:0100614)3.44021851
11Abnormality of macrophages (HP:0004311)3.43811462
12Gastrointestinal infarctions (HP:0005244)3.42230247
13Pustule (HP:0200039)3.36502368
14Granulocytopenia (HP:0001913)3.31438619
15Abnormality of T cell physiology (HP:0011840)3.28129953
16Gastrointestinal stroma tumor (HP:0100723)3.22428737
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.10433233
18Retrobulbar optic neuritis (HP:0100654)3.08614269
19Optic neuritis (HP:0100653)3.08614269
20Encephalitis (HP:0002383)3.06434567
21Stomach cancer (HP:0012126)3.05421609
22Orchitis (HP:0100796)3.02809112
23Abnormality of eosinophils (HP:0001879)3.01688034
24Recurrent bronchitis (HP:0002837)2.99132808
25Episodic fever (HP:0001954)2.97566923
26Vasculitis (HP:0002633)2.85740623
27Joint swelling (HP:0001386)2.82788358
28Poikiloderma (HP:0001029)2.81892395
29B lymphocytopenia (HP:0010976)2.80977373
30Severe combined immunodeficiency (HP:0004430)2.80462315
31Abnormal enzyme/coenzyme activity (HP:0012379)2.75359068
32Abnormality of B cell number (HP:0010975)2.74744560
33Spontaneous hematomas (HP:0007420)2.74585901
34Recurrent abscess formation (HP:0002722)2.71968315
35Eosinophilia (HP:0001880)2.71474711
36Recurrent bacterial skin infections (HP:0005406)2.66481087
37Recurrent fungal infections (HP:0002841)2.63470532
38Mediastinal lymphadenopathy (HP:0100721)2.61956429
39Meningitis (HP:0001287)2.59847240
40Chromsome breakage (HP:0040012)2.58273095
41Elevated alkaline phosphatase (HP:0003155)2.56031515
42Abnormality of alkaline phosphatase activity (HP:0004379)2.54960484
43Combined immunodeficiency (HP:0005387)2.49957118
44Recurrent viral infections (HP:0004429)2.42681639
45Anorexia (HP:0002039)2.42266930
46Hemorrhage of the eye (HP:0011885)2.41226900
47Prostate neoplasm (HP:0100787)2.38406208
48Facial diplegia (HP:0001349)2.35051763
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.34367143
50Obstructive lung disease (HP:0006536)2.33978070
51Chronic obstructive pulmonary disease (HP:0006510)2.33978070
52Abnormality of cochlea (HP:0000375)2.32831498
53Pulmonary infiltrates (HP:0002113)2.31264377
54Keratoconjunctivitis (HP:0001096)2.27443411
55Increased IgE level (HP:0003212)2.26930414
56Large eyes (HP:0001090)2.25817098
57Panhypogammaglobulinemia (HP:0003139)2.25305204
58Premature graying of hair (HP:0002216)2.25211209
59Lymphopenia (HP:0001888)2.23238018
60Premature loss of primary teeth (HP:0006323)2.22159271
61Prolonged bleeding time (HP:0003010)2.21349914
62Absent speech (HP:0001344)2.17971383
63Epistaxis (HP:0000421)2.17298814
64Elevated erythrocyte sedimentation rate (HP:0003565)2.16638768
65Keratoconjunctivitis sicca (HP:0001097)2.16337106
66Choroideremia (HP:0001139)2.15909643
67Nasal polyposis (HP:0100582)2.15801637
68Abnormality of carpal bone ossification (HP:0006257)2.15441581
69Broad face (HP:0000283)2.15088332
70Bulbar palsy (HP:0001283)2.13781386
71IgA deficiency (HP:0002720)2.13050305
72Tented upper lip vermilion (HP:0010804)2.11881218
73Leukocytosis (HP:0001974)2.10359022
74Inflammation of the large intestine (HP:0002037)2.09917959
75Alveolar cell carcinoma (HP:0006519)2.09389692
76Recurrent sinusitis (HP:0011108)2.08470792
77Gastrointestinal inflammation (HP:0004386)2.08189307
78Hemoptysis (HP:0002105)2.07853577
79Abnormality of the periventricular white matter (HP:0002518)2.07553598
80Verrucae (HP:0200043)2.07237058
81Papilloma (HP:0012740)2.07237058
82Joint hemorrhage (HP:0005261)2.06833564
83Abnormality of the prostate (HP:0008775)2.05897889
84Basal cell carcinoma (HP:0002671)2.04501208
85Easy fatigability (HP:0003388)2.04051175
86Attenuation of retinal blood vessels (HP:0007843)2.03312999
87Hypertriglyceridemia (HP:0002155)2.02906498
88Petechiae (HP:0000967)2.02323618
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.01798607
90Chest pain (HP:0100749)1.98933144
91Urticaria (HP:0001025)1.98421272
92Keratitis (HP:0000491)1.98399365
93Neutropenia (HP:0001875)1.97476048
94Neoplasm of the tracheobronchial system (HP:0100552)1.96491284
95Emphysema (HP:0002097)1.93627361
96Absent thumb (HP:0009777)1.93001326
97Recurrent cutaneous fungal infections (HP:0011370)1.91611149
98Chronic mucocutaneous candidiasis (HP:0002728)1.91611149
99Long palpebral fissure (HP:0000637)1.89333832
100Squamous cell carcinoma (HP:0002860)1.88452534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.83321587
2GRK64.60592062
3MUSK4.44640852
4MAP4K14.13394540
5MAP2K23.62562557
6PLK43.32088980
7CDK83.05919688
8TXK2.48271142
9ZAP702.06643783
10TESK21.98776411
11SIK31.97362493
12MAP3K141.93498914
13RIPK41.83325468
14SIK21.79873421
15CSK1.68180307
16BLK1.59035357
17FGR1.51876880
18JAK11.49308000
19FES1.49274853
20MARK31.45528245
21MAPK151.41677997
22MST41.41471711
23MATK1.34094399
24PRKD21.33785307
25TNK21.26985094
26SIK11.26596296
27CSF1R1.25794210
28MAP2K11.25097699
29BTK1.23801114
30JAK31.18448030
31STK101.18350363
32MAP3K111.16157280
33KDR1.15741803
34ITK1.15282534
35PRPF4B1.15066000
36IKBKE1.10616612
37TBK11.09102981
38LCK1.08148550
39PIM11.07526926
40CDK41.06883670
41SYK1.04353988
42PTK2B1.01139108
43TRIB31.00735055
44IRAK31.00456623
45IKBKB0.98146932
46TYK20.96081072
47MAP3K70.92017902
48HCK0.90974220
49KIT0.88513159
50MAP2K30.86659032
51ERN10.85416428
52CDK120.82505638
53NUAK10.78360563
54BMX0.78265691
55LYN0.77490301
56CDK30.76773056
57TLK10.75904600
58DYRK30.71881858
59MAPK110.65719079
60RPS6KB20.62787074
61PDK10.61865953
62ADRBK20.61757984
63PRKCQ0.61733032
64PLK20.61108630
65MAPK120.59329911
66IRAK40.54321566
67CDK90.53628625
68EPHB10.51741044
69PDPK10.48683928
70CDK60.48020577
71FGFR40.47102144
72RPS6KA60.46709424
73RPS6KL10.44698373
74RPS6KC10.44698373
75MAP3K10.42740487
76MAP3K30.39421803
77RAF10.38953712
78MAP3K100.38038375
79RPS6KA20.37971049
80DYRK1B0.34704463
81RET0.31880768
82PDGFRB0.31586606
83NEK20.31561339
84ICK0.31205840
85MARK20.29209428
86PRKD10.28041994
87DAPK20.27740909
88MAPK70.27559228
89TAOK20.26652581
90ABL10.25981487
91PINK10.25927193
92MAP3K120.25513825
93PRKCD0.24631218
94JAK20.22886513
95LRRK20.21722647
96STK380.21700898
97PRKCH0.21581018
98INSR0.21433895
99FYN0.20755702
100MAPKAPK20.20745933

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.35653542
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.15513226
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.12710663
4T cell receptor signaling pathway_Homo sapiens_hsa046602.86975744
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.79387239
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72560721
7Graft-versus-host disease_Homo sapiens_hsa053322.67128828
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62702868
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.37697778
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20674047
11Osteoclast differentiation_Homo sapiens_hsa043802.14401147
12Allograft rejection_Homo sapiens_hsa053302.07314594
13Leishmaniasis_Homo sapiens_hsa051402.07233453
14Autoimmune thyroid disease_Homo sapiens_hsa053201.98188519
15Antigen processing and presentation_Homo sapiens_hsa046121.95659126
16B cell receptor signaling pathway_Homo sapiens_hsa046621.90150968
17Measles_Homo sapiens_hsa051621.77574951
18TNF signaling pathway_Homo sapiens_hsa046681.75193273
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71676870
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70645530
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62951613
22N-Glycan biosynthesis_Homo sapiens_hsa005101.49390424
23Other glycan degradation_Homo sapiens_hsa005111.47947304
24Herpes simplex infection_Homo sapiens_hsa051681.46581407
25Apoptosis_Homo sapiens_hsa042101.46450504
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46178329
27Viral myocarditis_Homo sapiens_hsa054161.42016668
28Acute myeloid leukemia_Homo sapiens_hsa052211.34818801
29Basal transcription factors_Homo sapiens_hsa030221.30740153
30Hematopoietic cell lineage_Homo sapiens_hsa046401.29263947
31Shigellosis_Homo sapiens_hsa051311.26620547
32Type I diabetes mellitus_Homo sapiens_hsa049401.25666282
33Chemokine signaling pathway_Homo sapiens_hsa040621.20067248
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19453743
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16536040
36Malaria_Homo sapiens_hsa051441.16275560
37Non-homologous end-joining_Homo sapiens_hsa034501.11090268
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06979308
39Staphylococcus aureus infection_Homo sapiens_hsa051501.06693655
40Toxoplasmosis_Homo sapiens_hsa051451.06410664
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.03988588
42Tuberculosis_Homo sapiens_hsa051520.97919256
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97250216
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93749391
45Non-small cell lung cancer_Homo sapiens_hsa052230.92598407
46mTOR signaling pathway_Homo sapiens_hsa041500.87950183
47Endocytosis_Homo sapiens_hsa041440.85657758
48Legionellosis_Homo sapiens_hsa051340.84781093
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83993945
50Sulfur relay system_Homo sapiens_hsa041220.82823677
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.81950898
52Nucleotide excision repair_Homo sapiens_hsa034200.80004256
53Fanconi anemia pathway_Homo sapiens_hsa034600.77532533
54Epstein-Barr virus infection_Homo sapiens_hsa051690.77385976
55Lysosome_Homo sapiens_hsa041420.71842035
56Hepatitis B_Homo sapiens_hsa051610.71725853
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70880306
58Regulation of autophagy_Homo sapiens_hsa041400.68732387
59Viral carcinogenesis_Homo sapiens_hsa052030.67849826
60Asthma_Homo sapiens_hsa053100.67165460
61Hepatitis C_Homo sapiens_hsa051600.64404313
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.62323746
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.62309033
64Platelet activation_Homo sapiens_hsa046110.61990315
65Choline metabolism in cancer_Homo sapiens_hsa052310.61785024
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61289222
67Influenza A_Homo sapiens_hsa051640.60946426
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58457706
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.57264762
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.55199885
71VEGF signaling pathway_Homo sapiens_hsa043700.54774818
72Thyroid cancer_Homo sapiens_hsa052160.54628190
73Rheumatoid arthritis_Homo sapiens_hsa053230.54296022
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.54220006
75Salmonella infection_Homo sapiens_hsa051320.53327767
76Arachidonic acid metabolism_Homo sapiens_hsa005900.52649013
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50642530
78HTLV-I infection_Homo sapiens_hsa051660.50343631
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50043437
80Prolactin signaling pathway_Homo sapiens_hsa049170.49196585
81MAPK signaling pathway_Homo sapiens_hsa040100.47106814
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46472742
83Homologous recombination_Homo sapiens_hsa034400.44792679
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44782726
85Pertussis_Homo sapiens_hsa051330.44552827
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40291173
87Sphingolipid metabolism_Homo sapiens_hsa006000.38499243
88Ether lipid metabolism_Homo sapiens_hsa005650.36433650
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35993951
90Phenylalanine metabolism_Homo sapiens_hsa003600.33917296
91African trypanosomiasis_Homo sapiens_hsa051430.32848649
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31269787
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30935882
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.30689409
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30524467
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27436837
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26413033
98Nitrogen metabolism_Homo sapiens_hsa009100.25895483
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24799599
100Cell cycle_Homo sapiens_hsa041100.23668763

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