PRSS23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)7.68031804
2collagen fibril organization (GO:0030199)6.53762676
3skin morphogenesis (GO:0043589)5.89930977
4protein heterotrimerization (GO:0070208)5.70517869
5sequestering of extracellular ligand from receptor (GO:0035581)5.68229404
6wound healing, spreading of epidermal cells (GO:0035313)5.26439001
7endodermal cell differentiation (GO:0035987)4.77742482
8cell adhesion mediated by integrin (GO:0033627)4.75502640
9mesenchymal-epithelial cell signaling (GO:0060638)4.68567206
10Golgi transport vesicle coating (GO:0048200)4.65466575
11COPI coating of Golgi vesicle (GO:0048205)4.65466575
12positive regulation of endothelial cell apoptotic process (GO:2000353)4.49102029
13protein maturation by protein folding (GO:0022417)4.28457750
14wound healing, spreading of cells (GO:0044319)4.27337563
15bone trabecula formation (GO:0060346)4.26900050
16dermatan sulfate biosynthetic process (GO:0030208)4.21568896
17type B pancreatic cell proliferation (GO:0044342)4.13699401
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.12918928
19negative regulation of fatty acid transport (GO:2000192)4.12338395
20craniofacial suture morphogenesis (GO:0097094)3.91935738
21muscle cell migration (GO:0014812)3.91123666
22collagen metabolic process (GO:0032963)3.89758359
23protein localization to cell surface (GO:0034394)3.82271977
24dermatan sulfate metabolic process (GO:0030205)3.82218045
25axon extension involved in axon guidance (GO:0048846)3.78681949
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.78681949
27collagen catabolic process (GO:0030574)3.75930349
28positive regulation of blood vessel endothelial cell migration (GO:0043536)3.70064970
29negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.67134201
30extracellular fibril organization (GO:0043206)3.64635798
31multicellular organismal macromolecule metabolic process (GO:0044259)3.63966431
32hemidesmosome assembly (GO:0031581)3.59996102
33negative regulation of cartilage development (GO:0061037)3.59662013
34epithelial cell-cell adhesion (GO:0090136)3.57423910
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48905132
36fibril organization (GO:0097435)3.48855497
37glomerular epithelial cell development (GO:0072310)3.48016366
38cranial suture morphogenesis (GO:0060363)3.47145823
39multicellular organismal catabolic process (GO:0044243)3.46647468
40retina vasculature morphogenesis in camera-type eye (GO:0061299)3.46543714
41multicellular organismal metabolic process (GO:0044236)3.44669230
42membrane raft organization (GO:0031579)3.43093170
43cellular response to vitamin (GO:0071295)3.42650092
44positive regulation of macrophage activation (GO:0043032)3.41969038
45stress fiber assembly (GO:0043149)3.41723973
46protein retention in ER lumen (GO:0006621)3.41294049
47cell migration involved in sprouting angiogenesis (GO:0002042)3.41076675
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39834898
49glomerular visceral epithelial cell development (GO:0072015)3.39476842
50extracellular matrix disassembly (GO:0022617)3.39019215
51vascular endothelial growth factor signaling pathway (GO:0038084)3.38437227
52cellular response to vitamin D (GO:0071305)3.37595524
53extracellular matrix assembly (GO:0085029)3.35915219
54positive regulation of actin filament depolymerization (GO:0030836)3.34246722
55basement membrane organization (GO:0071711)3.34141993
56barbed-end actin filament capping (GO:0051016)3.33718076
57positive regulation of epithelial to mesenchymal transition (GO:0010718)3.32950393
58peptidyl-proline hydroxylation (GO:0019511)3.32401065
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.29994172
60endocardial cushion development (GO:0003197)3.27699629
61metanephric mesenchyme development (GO:0072075)3.27486919
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.25998140
63endothelium development (GO:0003158)3.22794225
64endothelial cell morphogenesis (GO:0001886)3.20628994
65regulation of tight junction assembly (GO:2000810)3.20295344
66plasma membrane repair (GO:0001778)3.18115237
67cell-substrate junction assembly (GO:0007044)3.16859799
68hippo signaling (GO:0035329)3.16685145
69blood vessel maturation (GO:0001955)3.15972422
70embryonic body morphogenesis (GO:0010172)3.14105673
71apoptotic cell clearance (GO:0043277)3.13872891
72extracellular negative regulation of signal transduction (GO:1900116)3.12286081
73extracellular regulation of signal transduction (GO:1900115)3.12286081
74protein targeting to plasma membrane (GO:0072661)3.11672197
75regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.09150256
76substrate-dependent cell migration (GO:0006929)3.07965256
77sprouting angiogenesis (GO:0002040)3.07623171
78glomerular basement membrane development (GO:0032836)3.06872521
79regulation of chondrocyte differentiation (GO:0032330)3.06204366
80positive regulation of cartilage development (GO:0061036)3.04991147
81regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.04432775
82desmosome organization (GO:0002934)3.02596070
83negative regulation of chondrocyte differentiation (GO:0032331)3.02055567
84cardiac epithelial to mesenchymal transition (GO:0060317)3.01644015
85kidney mesenchyme development (GO:0072074)3.00780088
86adherens junction assembly (GO:0034333)3.00271231
87endothelial tube morphogenesis (GO:0061154)3.00214828
88morphogenesis of an endothelium (GO:0003159)3.00214828
89protein localization to endosome (GO:0036010)3.00178763
90pattern specification involved in kidney development (GO:0061004)3.00119475
91extracellular matrix organization (GO:0030198)2.99496793
92regulation of metalloenzyme activity (GO:0048552)2.98916098
93negative regulation of stem cell proliferation (GO:2000647)2.98809644
94extracellular structure organization (GO:0043062)2.98041817
95substrate adhesion-dependent cell spreading (GO:0034446)2.96849877
96positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.94481753
97epithelial to mesenchymal transition (GO:0001837)2.94256691
98response to gravity (GO:0009629)2.92601219
99middle ear morphogenesis (GO:0042474)2.92455460
100smooth muscle tissue development (GO:0048745)2.92032284
101negative regulation of smooth muscle cell migration (GO:0014912)2.90703864
102wound healing (GO:0042060)2.90262288
103lymphangiogenesis (GO:0001946)2.90178973
104regulation of plasminogen activation (GO:0010755)2.89479616
105cell migration involved in heart development (GO:0060973)2.89357378
106regulation of integrin-mediated signaling pathway (GO:2001044)2.88706378
107embryonic cranial skeleton morphogenesis (GO:0048701)2.88380889
108negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.85863547
109epoxygenase P450 pathway (GO:0019373)2.85481233
110actin filament depolymerization (GO:0030042)2.84559545
111vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84450115
112regulation of cartilage development (GO:0061035)2.84279427
113positive regulation of endothelial cell migration (GO:0010595)2.83607834
114keratinocyte proliferation (GO:0043616)2.81802154
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81104797
116body morphogenesis (GO:0010171)2.80684615
117cellular response to interferon-alpha (GO:0035457)2.80516675
118negative regulation of anoikis (GO:2000811)2.80418761
119positive regulation of osteoblast proliferation (GO:0033690)2.77359398
120protein hydroxylation (GO:0018126)2.76586389
121outer ear morphogenesis (GO:0042473)2.76459707
122cell-substrate adherens junction assembly (GO:0007045)2.75613790
123focal adhesion assembly (GO:0048041)2.75613790
124chondrocyte development (GO:0002063)2.75181142
125membrane protein ectodomain proteolysis (GO:0006509)2.74428258
126negative regulation of adherens junction organization (GO:1903392)2.74219951
127negative regulation of focal adhesion assembly (GO:0051895)2.74219951
128negative regulation of cell junction assembly (GO:1901889)2.74219951
129SMAD protein complex assembly (GO:0007183)2.73726652
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72517373
131positive regulation of collagen biosynthetic process (GO:0032967)2.72086378
132mesodermal cell differentiation (GO:0048333)2.71632813
133negative regulation of catenin import into nucleus (GO:0035414)2.71538148
134ganglion development (GO:0061548)2.70768696
135negative regulation of fibrinolysis (GO:0051918)2.70473590
136retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68518052
137endothelial cell proliferation (GO:0001935)2.68399613
138hypotonic response (GO:0006971)2.66636147
139positive regulation of epithelial cell migration (GO:0010634)2.64047395
140regulation of transforming growth factor beta2 production (GO:0032909)2.62977508
141mitotic nuclear envelope reassembly (GO:0007084)2.61623566
142nuclear envelope reassembly (GO:0031468)2.61623566
143regulation of glomerular filtration (GO:0003093)2.60675095
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.55418283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human7.73569441
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.36217076
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.89936650
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.84327125
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.40776833
6CLOCK_20551151_ChIP-Seq_293T_Human3.17191141
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.02520830
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.86383645
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.71031843
10CJUN_26792858_Chip-Seq_BT549_Human2.57970586
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46858919
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.46386966
13* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.38712449
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.37353734
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.34120446
16NRF2_20460467_ChIP-Seq_MEFs_Mouse2.31777334
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.31777334
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.30929361
19* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25701672
20BRD4_25478319_ChIP-Seq_HGPS_Human2.25245062
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17403281
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12553564
23* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12553564
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.11388347
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.94433083
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92853726
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.90726173
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88599063
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.74735201
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.74700603
31TP53_18474530_ChIP-ChIP_U2OS_Human1.72815153
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.72771595
33ZNF263_19887448_ChIP-Seq_K562_Human1.71267674
34* SOX2_20726797_ChIP-Seq_SW620_Human1.69957721
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.64672636
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63364676
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62679857
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61956378
39* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.61468262
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.59354729
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56994321
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.55440573
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54622410
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54325677
45TP53_22127205_ChIP-Seq_IMR90_Human1.48188306
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47796830
47* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46431149
48* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46336024
49* ATF3_27146783_Chip-Seq_COLON_Human1.44658454
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43456764
51TP53_16413492_ChIP-PET_HCT116_Human1.43430571
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.41350290
53* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37475373
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.36005336
55* TP53_23651856_ChIP-Seq_MEFs_Mouse1.35750170
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33739026
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28242394
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27116021
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.26555150
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24995221
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24854045
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23784676
63AR_21909140_ChIP-Seq_LNCAP_Human1.21498258
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20911104
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.20211671
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20052907
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19463770
68AHR_22903824_ChIP-Seq_MCF-7_Human1.18881342
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17777694
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16318103
71RACK7_27058665_Chip-Seq_MCF-7_Human1.15520212
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.14917778
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14563823
74* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14438028
75* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14438028
76* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14171746
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13570826
78* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11956995
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10957183
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.10808381
81* NFI_21473784_ChIP-Seq_ESCs_Mouse1.10801937
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10509017
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.10108770
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.10108770
85EOMES_21245162_ChIP-Seq_HESCs_Human1.10078986
86* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09630977
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05635268
88SA1_22415368_ChIP-Seq_MEFs_Mouse1.05052572
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03885301
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.03048974
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02930482
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02864022
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01465498
94* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99556264
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.97720760
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97174574
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96902800
98KLF5_25053715_ChIP-Seq_YYC3_Human0.95756689
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94716044
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93507136
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93351237
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91328416
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90731399
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90516637
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87025841
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.86679351
107TP63_23658742_ChIP-Seq_EP156T_Human0.86383660
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86220379
109* ISL1_27105846_Chip-Seq_CPCs_Mouse0.86219230
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85717014
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.83891244
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83843630
113* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83606515
114* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83577672
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83373116
116JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82449591
117* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82270105
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81885088
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81140019
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80741405
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80072136
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.77607298
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75959728
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75881437
125PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.75870168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.88465149
2MP0005275_abnormal_skin_tensile4.84044888
3MP0005503_abnormal_tendon_morphology4.32952019
4MP0003705_abnormal_hypodermis_morpholog3.69128247
5MP0003279_aneurysm3.44916305
6MP0001958_emphysema2.97621846
7MP0005623_abnormal_meninges_morphology2.92023650
8MP0004272_abnormal_basement_membrane2.91895619
9MP0009384_cardiac_valve_regurgitation2.54532419
10MP0003566_abnormal_cell_adhesion2.51553741
11MP0010030_abnormal_orbit_morphology2.43805230
12MP0005508_abnormal_skeleton_morphology2.32216030
13MP0003941_abnormal_skin_development2.30440548
14MP0002060_abnormal_skin_morphology2.20557939
15MP0006054_spinal_hemorrhage2.14793931
16MP0001542_abnormal_bone_strength2.10046928
17MP0005257_abnormal_intraocular_pressure2.07908936
18MP0010352_gastrointestinal_tract_polyps1.96698368
19MP0003091_abnormal_cell_migration1.93929581
20MP0005023_abnormal_wound_healing1.91151614
21MP0009250_abnormal_appendicular_skeleto1.90984147
22MP0009379_abnormal_foot_pigmentation1.84065679
23MP0009053_abnormal_anal_canal1.78533315
24MP0010368_abnormal_lymphatic_system1.77933470
25MP0003385_abnormal_body_wall1.76187266
26MP0002877_abnormal_melanocyte_morpholog1.70782427
27MP0002295_abnormal_pulmonary_circulatio1.66042730
28MP0000013_abnormal_adipose_tissue1.59512802
29MP0001243_abnormal_dermal_layer1.58542037
30MP0001299_abnormal_eye_distance/1.49058880
31MP0000767_abnormal_smooth_muscle1.47912500
32MP0005197_abnormal_uvea_morphology1.47086897
33MP0003191_abnormal_cellular_cholesterol1.43780992
34MP0005390_skeleton_phenotype1.40947548
35MP0002896_abnormal_bone_mineralization1.38347665
36MP0000733_abnormal_muscle_development1.37605588
37MP0005165_increased_susceptibility_to1.36522040
38MP0001879_abnormal_lymphatic_vessel1.29424488
39MP0002108_abnormal_muscle_morphology1.28369223
40MP0002282_abnormal_trachea_morphology1.26480038
41MP0003942_abnormal_urinary_system1.26444411
42MP0002933_joint_inflammation1.25941653
43MP0000163_abnormal_cartilage_morphology1.25696081
44MP0003828_pulmonary_edema1.24400334
45MP0001348_abnormal_lacrimal_gland1.24375133
46MP0003303_peritoneal_inflammation1.23850508
47MP0000750_abnormal_muscle_regeneration1.20381482
48MP0005595_abnormal_vascular_smooth1.18694055
49MP0003755_abnormal_palate_morphology1.15666910
50MP0000749_muscle_degeneration1.14316000
51MP0002115_abnormal_skeleton_extremities1.08390965
52MP0000537_abnormal_urethra_morphology1.05110586
53MP0004858_abnormal_nervous_system1.04059138
54MP0002932_abnormal_joint_morphology1.03629446
55MP0001915_intracranial_hemorrhage0.99679096
56MP0000762_abnormal_tongue_morphology0.98496650
57MP0001533_abnormal_skeleton_physiology0.98452661
58MP0003045_fibrosis0.98083608
59MP0003724_increased_susceptibility_to0.98031711
60MP0005084_abnormal_gallbladder_morpholo0.97416113
61MP0000428_abnormal_craniofacial_morphol0.97232371
62MP0000534_abnormal_ureter_morphology0.96671311
63MP0003115_abnormal_respiratory_system0.95956021
64MP0001849_ear_inflammation0.95644207
65MP0005367_renal/urinary_system_phenotyp0.95611314
66MP0000516_abnormal_urinary_system0.95611314
67MP0010386_abnormal_urinary_bladder0.94457213
68MP0000049_abnormal_middle_ear0.93842879
69MP0002089_abnormal_postnatal_growth/wei0.92945278
70MP0005193_abnormal_anterior_eye0.92044313
71MP0002113_abnormal_skeleton_development0.91808688
72MP0000003_abnormal_adipose_tissue0.91487238
73MP0009780_abnormal_chondrocyte_physiolo0.88266064
74MP0005171_absent_coat_pigmentation0.87035210
75MP0000467_abnormal_esophagus_morphology0.86940117
76MP0002128_abnormal_blood_circulation0.85898605
77MP0000759_abnormal_skeletal_muscle0.84283206
78MP0002332_abnormal_exercise_endurance0.83453312
79MP0002177_abnormal_outer_ear0.83396608
80MP0002168_other_aberrant_phenotype0.82487860
81MP0001614_abnormal_blood_vessel0.81776150
82MP0001346_abnormal_lacrimal_gland0.80615708
83MP0003950_abnormal_plasma_membrane0.78779992
84MP0005375_adipose_tissue_phenotype0.78209285
85MP0004185_abnormal_adipocyte_glucose0.78061942
86MP0010771_integument_phenotype0.77981221
87MP0006138_congestive_heart_failure0.77841991
88MP0002133_abnormal_respiratory_system0.77214193
89MP0005388_respiratory_system_phenotype0.77214193
90MP0000432_abnormal_head_morphology0.77143743
91MP0002796_impaired_skin_barrier0.77133319
92MP0004134_abnormal_chest_morphology0.77042164
93MP0005248_abnormal_Harderian_gland0.76217964
94MP0002092_abnormal_eye_morphology0.76173980
95MP0004087_abnormal_muscle_fiber0.75409642
96MP0000751_myopathy0.74715680
97MP0008004_abnormal_stomach_pH0.74086529
98MP0002111_abnormal_tail_morphology0.74008713
99MP0000462_abnormal_digestive_system0.72955956
100MP0003795_abnormal_bone_structure0.71518613
101MP0005330_cardiomyopathy0.70640501
102MP0003283_abnormal_digestive_organ0.69751047
103MP0001175_abnormal_lung_morphology0.69540036
104MP0004233_abnormal_muscle_weight0.69516797
105MP0002109_abnormal_limb_morphology0.69507468
106MP0002249_abnormal_larynx_morphology0.68886502
107MP0005164_abnormal_response_to0.68572535
108MP0002116_abnormal_craniofacial_bone0.68538210
109MP0002697_abnormal_eye_size0.68507334
110MP0002998_abnormal_bone_remodeling0.68418162
111MP0005408_hypopigmentation0.67535165
112MP0009697_abnormal_copulation0.66825315
113MP0003300_gastrointestinal_ulcer0.66735084
114MP0005058_abnormal_lysosome_morphology0.66427823
115MP0000343_altered_response_to0.65841154
116MP0003937_abnormal_limbs/digits/tail_de0.65523487
117MP0005501_abnormal_skin_physiology0.65125639
118MP0002925_abnormal_cardiovascular_devel0.64531018
119MP0003935_abnormal_craniofacial_develop0.63967285
120MP0002233_abnormal_nose_morphology0.63841887
121MP0000613_abnormal_salivary_gland0.63574044
122MP0000858_altered_metastatic_potential0.62802692
123MP0008775_abnormal_heart_ventricle0.61569538
124MP0010234_abnormal_vibrissa_follicle0.56246060
125MP0001340_abnormal_eyelid_morphology0.56223496

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)9.56347689
2Protrusio acetabuli (HP:0003179)8.66554765
3Aortic dissection (HP:0002647)5.68424754
4Soft skin (HP:0000977)4.94814245
5Atrophic scars (HP:0001075)4.75041099
6Aortic aneurysm (HP:0004942)4.64496253
7Cerebral aneurysm (HP:0004944)4.62113508
8Peritonitis (HP:0002586)4.47460326
9Shallow orbits (HP:0000586)4.36629986
10Fragile skin (HP:0001030)4.23972701
11Dilatation of the ascending aorta (HP:0005111)4.15565360
12Abnormality of dentin (HP:0010299)3.98821185
13Vertebral compression fractures (HP:0002953)3.86913169
14Biconcave vertebral bodies (HP:0004586)3.75921134
15Neonatal short-limb short stature (HP:0008921)3.73148502
16Spinal rigidity (HP:0003306)3.42649799
17Bladder diverticulum (HP:0000015)3.39846368
18Genu recurvatum (HP:0002816)3.36257085
19Blue sclerae (HP:0000592)3.33414965
20Wormian bones (HP:0002645)3.33339848
21Ankle contracture (HP:0006466)3.28234937
22Mitral valve prolapse (HP:0001634)3.26613837
23Cervical subluxation (HP:0003308)3.24585784
24Increased connective tissue (HP:0009025)3.22912806
25Abnormal delivery (HP:0001787)3.16295565
26Short nail (HP:0001799)3.06168180
27Cardiovascular calcification (HP:0011915)2.98812002
28Round ear (HP:0100830)2.89762358
29Type 1 muscle fiber predominance (HP:0003803)2.85681569
30Broad metatarsal (HP:0001783)2.83014790
31Wrist flexion contracture (HP:0001239)2.78441246
32Hyperextensible skin (HP:0000974)2.71802908
33Vascular tortuosity (HP:0004948)2.71776586
34Mitral stenosis (HP:0001718)2.69860785
35Overgrowth (HP:0001548)2.64254677
36Reduced subcutaneous adipose tissue (HP:0003758)2.62887891
37Mitral regurgitation (HP:0001653)2.59518290
38Entropion (HP:0000621)2.56805363
39Glucose intolerance (HP:0000833)2.55263151
40Wide anterior fontanel (HP:0000260)2.49741733
41Infantile muscular hypotonia (HP:0008947)2.48888716
42Absent frontal sinuses (HP:0002688)2.48103779
43Mildly elevated creatine phosphokinase (HP:0008180)2.45732482
44Abnormality of the acetabulum (HP:0003170)2.44966228
45Natal tooth (HP:0000695)2.43823933
46Elbow flexion contracture (HP:0002987)2.43608150
47Aortic regurgitation (HP:0001659)2.37085868
48Osteolytic defects of the hand bones (HP:0009699)2.36972494
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.36972494
50Bowel diverticulosis (HP:0005222)2.34600345
51Aneurysm (HP:0002617)2.34109802
52Achilles tendon contracture (HP:0001771)2.32498657
53Aplasia involving bones of the extremities (HP:0009825)2.29731204
54Aplasia involving bones of the upper limbs (HP:0009823)2.29731204
55Aplasia of the phalanges of the hand (HP:0009802)2.29731204
56Coronal craniosynostosis (HP:0004440)2.29657370
57Venous abnormality (HP:0002624)2.29332745
58Calcaneovalgus deformity (HP:0001848)2.27338693
59Mesomelia (HP:0003027)2.26161952
60Increased density of long bones (HP:0006392)2.24980511
61Distal lower limb amyotrophy (HP:0008944)2.23923235
62Scapular winging (HP:0003691)2.23255216
63Hypoplasia of the iris (HP:0007676)2.22793951
64Deformed tarsal bones (HP:0008119)2.21169335
65Camptodactyly of toe (HP:0001836)2.21073978
66Difficulty climbing stairs (HP:0003551)2.18963510
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.18873338
68Vascular calcification (HP:0004934)2.18570328
69Arterial tortuosity (HP:0005116)2.17509190
70Breech presentation (HP:0001623)2.17474786
71Aortic valve stenosis (HP:0001650)2.16011514
72Upper limb amyotrophy (HP:0009129)2.15597574
73Distal upper limb amyotrophy (HP:0007149)2.15597574
74Nonimmune hydrops fetalis (HP:0001790)2.15528977
75Abnormality of the calcaneus (HP:0008364)2.14947144
76Increased variability in muscle fiber diameter (HP:0003557)2.13900582
77Limb-girdle muscle atrophy (HP:0003797)2.09793935
78Deviation of the hallux (HP:0010051)2.07910078
79Hallux valgus (HP:0001822)2.06159811
80Abnormality of the Achilles tendon (HP:0005109)2.04946100
81Distal lower limb muscle weakness (HP:0009053)2.03297793
82Follicular hyperkeratosis (HP:0007502)2.03285649
83Hand muscle atrophy (HP:0009130)2.03169595
84Venous insufficiency (HP:0005293)2.01442320
85Broad face (HP:0000283)2.00841928
86Syringomyelia (HP:0003396)1.99387568
87Spinal cord lesions (HP:0100561)1.99387568
88Thin skin (HP:0000963)1.98382767
89Morphological abnormality of the middle ear (HP:0008609)1.97726597
90Coxa vara (HP:0002812)1.97366050
91Abnormality of skeletal muscle fiber size (HP:0012084)1.95493519
92Joint laxity (HP:0001388)1.95285358
93Ulnar bowing (HP:0003031)1.95184405
94Tibial bowing (HP:0002982)1.93488545
95Bell-shaped thorax (HP:0001591)1.92918693
96Abnormality of the distal phalanges of the toes (HP:0010182)1.92257383
97Osteopenia (HP:0000938)1.91170888
98Ectopia lentis (HP:0001083)1.91136936
99Decreased skull ossification (HP:0004331)1.88456817
100Joint stiffness (HP:0001387)1.87471719
101Microglossia (HP:0000171)1.87456498
102Gastrointestinal dysmotility (HP:0002579)1.86929811
103Tarsal synostosis (HP:0008368)1.86189376
104Abnormality of the peritoneum (HP:0002585)1.85958848
105Knee flexion contracture (HP:0006380)1.85295464
106Right ventricular cardiomyopathy (HP:0011663)1.84620640
107Osteoarthritis (HP:0002758)1.83332511
108Buphthalmos (HP:0000557)1.83198791
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83006755
110Slender build (HP:0001533)1.81778829
111Striae distensae (HP:0001065)1.81419166
112Spondylolisthesis (HP:0003302)1.80805433
113Delayed gross motor development (HP:0002194)1.80497249
114Mild short stature (HP:0003502)1.79979134
115Abnormality of skull ossification (HP:0002703)1.77857897
116Delayed cranial suture closure (HP:0000270)1.77393292
117Ovoid vertebral bodies (HP:0003300)1.77353462
118Tetraparesis (HP:0002273)1.77349716
119Distal arthrogryposis (HP:0005684)1.76088007
120Beaking of vertebral bodies (HP:0004568)1.75402451
121Hydroureter (HP:0000072)1.73432986
122Disproportionate tall stature (HP:0001519)1.73218174
123Adrenal hypoplasia (HP:0000835)1.72668442
124Femoral bowing (HP:0002980)1.71602701
125Spinal cord compression (HP:0002176)1.71483940
126Abnormality of the nasal mucosa (HP:0000433)1.71177304
127Lower limb amyotrophy (HP:0007210)1.69872123
128Short clavicles (HP:0000894)1.67777232
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66749056
130Full cheeks (HP:0000293)1.66511370
131Generalized amyotrophy (HP:0003700)1.65828297
132Long toe (HP:0010511)1.65588038
133Trismus (HP:0000211)1.64642044
134Protruding ear (HP:0000411)1.64501863
135Abnormality of the frontal sinuses (HP:0002687)1.64249255
136Inguinal hernia (HP:0000023)1.63156917
137Bradycardia (HP:0001662)1.62405835
138Abnormality of the anterior chamber (HP:0000593)1.61809530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.77331497
2TTN3.55244650
3TIE13.45096238
4FER3.41408188
5TRIB33.40432433
6LATS23.17929836
7TESK13.14476937
8LIMK12.98622140
9LATS12.76876490
10PDGFRA2.64583374
11DMPK2.47412999
12PIM22.45383991
13TRPM72.33102823
14EPHB22.30135367
15PKN22.13012915
16PAK22.12992215
17EIF2AK12.03375363
18PIK3CG1.96404825
19TESK21.94760766
20MYLK1.94437070
21NEK91.88776223
22ERN11.82712733
23PIK3CA1.82136382
24LMTK21.80512795
25PTK2B1.80453729
26ARAF1.74131154
27PAK41.55599235
28PTK21.53963189
29MAP3K121.51144690
30PAK31.47297858
31NME21.37626480
32ERBB31.36192037
33VRK21.35915415
34STK38L1.29504195
35FRK1.28504067
36STK381.23123286
37RIPK11.19845347
38TGFBR21.19192149
39IRAK31.17626364
40MOS1.14736010
41DAPK31.13312974
42MAPKAPK31.13020762
43FES1.11937972
44DYRK1B1.09071362
45ROCK11.08788367
46BMX1.06005928
47LRRK21.05789657
48EPHA21.05467585
49EPHA31.03732419
50ILK1.00606622
51PTK60.99919450
52MET0.91069265
53NUAK10.89833343
54STK30.89278481
55NEK10.84483934
56MINK10.81552333
57ICK0.80151038
58TAOK10.78892315
59SIK10.77353714
60PRKD30.74783913
61CSK0.73375778
62CDK140.73374260
63FGFR10.73304655
64MAP3K30.71469416
65KDR0.70758702
66RPS6KA40.70244624
67CDK60.68478191
68CDC42BPA0.67981706
69PDGFRB0.64883276
70MAP2K10.64675202
71MAP3K110.60630774
72PRKD10.60399590
73PAK10.60070780
74INSR0.57262494
75CAMK2G0.55428045
76PBK0.55376349
77ABL20.54631743
78PRKG20.54200166
79ADRBK10.53487317
80GSK3A0.51313313
81PRKD20.51227427
82ROCK20.51050695
83NTRK10.50894930
84BCR0.49064452
85SMG10.48635828
86PLK20.48236220
87MTOR0.45969645
88MAP2K70.45259456
89CDK150.45165444
90TLK10.44528431
91BRAF0.44102284
92FLT30.43262513
93RET0.43109875
94MKNK10.42942108
95CDK80.42885498
96PAK60.42863076
97MAPK150.42262044
98MELK0.40969418
99CDK180.39969753
100SRC0.37936577
101CDK11A0.37513288
102AURKA0.37030221
103CDK90.36006836
104NEK20.35649448
105DAPK10.35536167
106PRKCE0.35150139
107SCYL20.32678276
108RPS6KA20.32632015
109CAMK2D0.32558921
110PDK20.32533609
111MAP3K80.32512203
112ERBB20.32046367
113MST1R0.31541197
114MAPKAPK50.31266586
115ZAK0.30660831
116EPHB10.29954525
117STK100.29809892
118BUB10.29778592
119ERBB40.29737700
120TGFBR10.28647562
121MAPK70.28624230
122CSNK1A1L0.27514480
123TAOK20.27125311
124BRSK10.27101154
125MAPKAPK20.27016623
126MAP3K50.26961546
127AURKB0.26039922
128ABL10.24925073
129WNK10.23567097
130GRK50.23442750
131IGF1R0.22768080

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.13927011
2Focal adhesion_Homo sapiens_hsa045103.27426032
3Bladder cancer_Homo sapiens_hsa052193.03128185
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.78548951
5Proteoglycans in cancer_Homo sapiens_hsa052052.61227828
6TGF-beta signaling pathway_Homo sapiens_hsa043502.52802778
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.48982944
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.47367794
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.33801343
10Dilated cardiomyopathy_Homo sapiens_hsa054142.30908241
11Hippo signaling pathway_Homo sapiens_hsa043902.28504344
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.27111307
13Adherens junction_Homo sapiens_hsa045202.24554599
14Protein digestion and absorption_Homo sapiens_hsa049742.22253917
15Malaria_Homo sapiens_hsa051442.13144109
16Amoebiasis_Homo sapiens_hsa051462.11369814
17MicroRNAs in cancer_Homo sapiens_hsa052061.80526466
18Small cell lung cancer_Homo sapiens_hsa052221.76164838
19p53 signaling pathway_Homo sapiens_hsa041151.72594687
20Melanoma_Homo sapiens_hsa052181.71278864
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.66729076
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.65231452
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60940927
24Tight junction_Homo sapiens_hsa045301.59765067
25Shigellosis_Homo sapiens_hsa051311.57325271
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54289504
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49299850
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48846822
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48838577
30Chronic myeloid leukemia_Homo sapiens_hsa052201.46373320
31Basal cell carcinoma_Homo sapiens_hsa052171.43435296
32Pentose phosphate pathway_Homo sapiens_hsa000301.41857274
33Galactose metabolism_Homo sapiens_hsa000521.39280588
34Viral myocarditis_Homo sapiens_hsa054161.35024661
35Protein export_Homo sapiens_hsa030601.30482919
36Glioma_Homo sapiens_hsa052141.26328607
37Other glycan degradation_Homo sapiens_hsa005111.22893986
38Folate biosynthesis_Homo sapiens_hsa007901.19269233
39Rap1 signaling pathway_Homo sapiens_hsa040151.19199298
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14903864
41Platelet activation_Homo sapiens_hsa046111.11887726
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10370197
43Wnt signaling pathway_Homo sapiens_hsa043101.09856915
44Axon guidance_Homo sapiens_hsa043601.06204033
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06066463
46Hedgehog signaling pathway_Homo sapiens_hsa043400.99818968
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.99601581
48Pathways in cancer_Homo sapiens_hsa052000.98410044
49Prostate cancer_Homo sapiens_hsa052150.95544063
50HTLV-I infection_Homo sapiens_hsa051660.91842568
51Pancreatic cancer_Homo sapiens_hsa052120.91538476
52HIF-1 signaling pathway_Homo sapiens_hsa040660.90130299
53Biosynthesis of amino acids_Homo sapiens_hsa012300.89352715
54Lysosome_Homo sapiens_hsa041420.86939187
55Melanogenesis_Homo sapiens_hsa049160.86932553
56TNF signaling pathway_Homo sapiens_hsa046680.85835802
57Salmonella infection_Homo sapiens_hsa051320.82166694
58Thyroid cancer_Homo sapiens_hsa052160.82116364
59Proteasome_Homo sapiens_hsa030500.81932630
60Fatty acid elongation_Homo sapiens_hsa000620.80710807
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79038689
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78880326
63Endocytosis_Homo sapiens_hsa041440.76642569
64Phagosome_Homo sapiens_hsa041450.76604293
65Gap junction_Homo sapiens_hsa045400.76140714
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75857556
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.72502343
68Ras signaling pathway_Homo sapiens_hsa040140.72227053
69Renal cell carcinoma_Homo sapiens_hsa052110.72186805
70Sphingolipid metabolism_Homo sapiens_hsa006000.69635725
71Fructose and mannose metabolism_Homo sapiens_hsa000510.68853112
72Sulfur metabolism_Homo sapiens_hsa009200.68677533
73Complement and coagulation cascades_Homo sapiens_hsa046100.67043766
74ErbB signaling pathway_Homo sapiens_hsa040120.66229838
75VEGF signaling pathway_Homo sapiens_hsa043700.66069889
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65922697
77Apoptosis_Homo sapiens_hsa042100.65228020
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63612897
79Nucleotide excision repair_Homo sapiens_hsa034200.62716983
80GnRH signaling pathway_Homo sapiens_hsa049120.61062977
81Toxoplasmosis_Homo sapiens_hsa051450.59772496
82Salivary secretion_Homo sapiens_hsa049700.58935840
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58719763
84Hepatitis B_Homo sapiens_hsa051610.58246212
85Notch signaling pathway_Homo sapiens_hsa043300.55884397
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.55148335
87Carbon metabolism_Homo sapiens_hsa012000.53910641
88Vibrio cholerae infection_Homo sapiens_hsa051100.53879969
89Pyrimidine metabolism_Homo sapiens_hsa002400.53182681
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52594237
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52141309
92Sulfur relay system_Homo sapiens_hsa041220.50411585
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.48899173
94Ovarian steroidogenesis_Homo sapiens_hsa049130.48671051
95Estrogen signaling pathway_Homo sapiens_hsa049150.47937831
96AMPK signaling pathway_Homo sapiens_hsa041520.47804329
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45698554
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.45270008
99Tyrosine metabolism_Homo sapiens_hsa003500.45160209
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.45001093
101Thyroid hormone synthesis_Homo sapiens_hsa049180.43915554
102Pyruvate metabolism_Homo sapiens_hsa006200.43685502
103Endometrial cancer_Homo sapiens_hsa052130.43445821
104Viral carcinogenesis_Homo sapiens_hsa052030.43269115
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42418995
106FoxO signaling pathway_Homo sapiens_hsa040680.41423709
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40401303
108Colorectal cancer_Homo sapiens_hsa052100.39920986
109Insulin signaling pathway_Homo sapiens_hsa049100.39387666
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38580280
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.38568136
112Chemical carcinogenesis_Homo sapiens_hsa052040.36832621
113N-Glycan biosynthesis_Homo sapiens_hsa005100.36078517
114Oxytocin signaling pathway_Homo sapiens_hsa049210.35814741
115MAPK signaling pathway_Homo sapiens_hsa040100.35194419
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34435932
117Glutathione metabolism_Homo sapiens_hsa004800.34268652
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34063220
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33527430
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32226198
121Phenylalanine metabolism_Homo sapiens_hsa003600.31374607
122Pertussis_Homo sapiens_hsa051330.31354752
123Steroid biosynthesis_Homo sapiens_hsa001000.31334310
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.30966459
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30424209
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27346371
127Circadian rhythm_Homo sapiens_hsa047100.27050738
128Starch and sucrose metabolism_Homo sapiens_hsa005000.26532920
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26283436
130Long-term depression_Homo sapiens_hsa047300.26021755
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25925191
132Arachidonic acid metabolism_Homo sapiens_hsa005900.24602308
133Ribosome_Homo sapiens_hsa030100.22828985
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21135760
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18956896

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