PRR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.07525622
2daunorubicin metabolic process (GO:0044597)9.07525622
3polyketide metabolic process (GO:0030638)9.07525622
4aminoglycoside antibiotic metabolic process (GO:0030647)7.55715364
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37637004
6negative regulation of cell killing (GO:0031342)5.37637004
7positive regulation of gamma-delta T cell activation (GO:0046645)4.40149695
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.11117940
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01963381
10negative regulation of interleukin-12 production (GO:0032695)3.96680403
11immunoglobulin mediated immune response (GO:0016064)3.72808261
12DNA replication checkpoint (GO:0000076)3.68673376
13protein localization to kinetochore (GO:0034501)3.61345411
14negative regulation of cytokine production involved in immune response (GO:0002719)3.55548528
15regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53834610
16regulation of natural killer cell mediated immunity (GO:0002715)3.53834610
17post-embryonic morphogenesis (GO:0009886)3.50041537
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.49050133
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49050133
20response to type I interferon (GO:0034340)3.48633027
21neutrophil activation involved in immune response (GO:0002283)3.48474680
22cellular response to type I interferon (GO:0071357)3.48028247
23type I interferon signaling pathway (GO:0060337)3.48028247
24regulation of gamma-delta T cell activation (GO:0046643)3.41393200
25DNA deamination (GO:0045006)3.40560267
26positive thymic T cell selection (GO:0045059)3.33585265
27regulation of mast cell degranulation (GO:0043304)3.33542933
28defense response to protozoan (GO:0042832)3.30512462
29NIK/NF-kappaB signaling (GO:0038061)3.28483924
30regulation of T cell tolerance induction (GO:0002664)3.26167042
31positive regulation of antigen processing and presentation (GO:0002579)3.25120807
32response to protozoan (GO:0001562)3.24613701
33negative regulation of innate immune response (GO:0045824)3.24233521
34negative regulation of meiosis (GO:0045835)3.21861875
35DNA strand elongation involved in DNA replication (GO:0006271)3.20549665
36protein localization to chromosome, centromeric region (GO:0071459)3.17824499
37regulation of T cell mediated cytotoxicity (GO:0001914)3.16972844
38detection of bacterium (GO:0016045)3.16683102
39regulation of mast cell activation involved in immune response (GO:0033006)3.16589879
40regulation of activation of Janus kinase activity (GO:0010533)3.15909633
41granulocyte activation (GO:0036230)3.14261583
42telomere maintenance via semi-conservative replication (GO:0032201)3.13681269
43regulation of stem cell maintenance (GO:2000036)3.13362817
44negative regulation of leukocyte mediated immunity (GO:0002704)3.12279224
45regulation of antigen processing and presentation (GO:0002577)3.11864051
46leukocyte aggregation (GO:0070486)3.09799154
47regulation of gamma-delta T cell differentiation (GO:0045586)3.09379839
48negative regulation of phagocytosis (GO:0050765)3.07893278
49response to peptidoglycan (GO:0032494)3.07322337
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07018919
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05695372
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.05695372
53modulation by symbiont of host immune response (GO:0052553)3.05695372
54positive regulation by symbiont of host defense response (GO:0052509)3.05695372
55modulation by symbiont of host defense response (GO:0052031)3.05695372
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05695372
57DNA strand elongation (GO:0022616)3.04658154
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04377627
59negative regulation of alpha-beta T cell activation (GO:0046636)3.03993430
60trivalent inorganic anion homeostasis (GO:0072506)3.02456639
61phosphate ion homeostasis (GO:0055062)3.02456639
62detection of other organism (GO:0098543)3.01978943
63positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00786740
64cellular response to interleukin-15 (GO:0071350)2.99996906
65negative regulation of mast cell activation (GO:0033004)2.99552056
66mitotic nuclear envelope disassembly (GO:0007077)2.99022135
67heterochromatin organization (GO:0070828)2.98637988
68response to interleukin-15 (GO:0070672)2.96639414
69regulation of mast cell activation (GO:0033003)2.96507078
70maturation of SSU-rRNA (GO:0030490)2.96311459
71tolerance induction (GO:0002507)2.95838357
72interferon-gamma-mediated signaling pathway (GO:0060333)2.94587409
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94400170
74macrophage activation involved in immune response (GO:0002281)2.93874886
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.93680574
76regulation of T-helper 1 cell differentiation (GO:0045625)2.93174336
77DNA replication initiation (GO:0006270)2.91197036
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.91002449
79mitotic metaphase plate congression (GO:0007080)2.87748233
80myeloid dendritic cell differentiation (GO:0043011)2.86688637
81intracellular estrogen receptor signaling pathway (GO:0030520)2.86651518
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86120616
83neutrophil activation (GO:0042119)2.83496782
84paraxial mesoderm development (GO:0048339)2.83449992
85DNA unwinding involved in DNA replication (GO:0006268)2.81957057
86negative regulation of T cell mediated immunity (GO:0002710)2.81397646
87telomere maintenance via recombination (GO:0000722)2.80776797
88myeloid cell activation involved in immune response (GO:0002275)2.79705393
89antigen processing and presentation of endogenous antigen (GO:0019883)2.78185756
90regulation of cell killing (GO:0031341)2.76696449
91negative T cell selection (GO:0043383)2.76328032
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76085931
93negative regulation of production of molecular mediator of immune response (GO:0002701)2.75861584
94regulation of tolerance induction (GO:0002643)2.74602763
95cellular anion homeostasis (GO:0030002)2.74416579
96regulation of cytokine secretion involved in immune response (GO:0002739)2.74054543
97histone H4-K12 acetylation (GO:0043983)2.73561870
98germinal center formation (GO:0002467)2.72526278
99interferon-gamma secretion (GO:0072643)2.72327812
100positive regulation of natural killer cell mediated immunity (GO:0002717)2.72248295
101ribosome assembly (GO:0042255)2.71547965
102positive regulation of DNA-dependent DNA replication (GO:2000105)2.71361232
103leukocyte degranulation (GO:0043299)2.71229592
104negative thymic T cell selection (GO:0045060)2.70731556
105positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.70706963
106positive regulation of natural killer cell differentiation (GO:0032825)2.70259680
107myeloid dendritic cell activation (GO:0001773)2.70232206
108T cell apoptotic process (GO:0070231)2.70039131
109T cell migration (GO:0072678)2.69950068
110Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69453709
111negative regulation of erythrocyte differentiation (GO:0045647)2.69063027
112regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69062113
113negative regulation of tumor necrosis factor production (GO:0032720)2.68896365
114low-density lipoprotein particle clearance (GO:0034383)2.66869352
115Peyers patch development (GO:0048541)2.66318607
116mucosal-associated lymphoid tissue development (GO:0048537)2.66318607
117nuclear envelope disassembly (GO:0051081)2.66296815
118membrane disassembly (GO:0030397)2.66296815
119B cell receptor signaling pathway (GO:0050853)2.66188877
120positive T cell selection (GO:0043368)2.65714221
121ribosomal small subunit assembly (GO:0000028)2.65287757
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64961421
123activated T cell proliferation (GO:0050798)2.64803392
124thymic T cell selection (GO:0045061)2.64547408
125response to interferon-beta (GO:0035456)2.64535781
126negative regulation of granulocyte differentiation (GO:0030853)2.63842197
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62785508
128regulation of translational fidelity (GO:0006450)2.62664134
129formation of translation preinitiation complex (GO:0001731)2.62158969
130negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.62044398
131detection of molecule of bacterial origin (GO:0032490)2.60988721
132ribosome biogenesis (GO:0042254)2.60279084
133regulation of leukocyte degranulation (GO:0043300)2.60221113
134lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60027804
135mitotic recombination (GO:0006312)2.59980634
136base-excision repair (GO:0006284)2.59815609
137negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59440989
138positive regulation of defense response to virus by host (GO:0002230)2.57915708
139B cell mediated immunity (GO:0019724)2.57911851
140telomere maintenance via telomere lengthening (GO:0010833)2.54706906
141folic acid-containing compound biosynthetic process (GO:0009396)2.54706896
142T cell selection (GO:0045058)2.53873485
143regulation of hippo signaling (GO:0035330)2.53541590
144negative regulation of interleukin-6 production (GO:0032715)2.52784736
145histone mRNA catabolic process (GO:0071044)2.52185622
146regulation of chronic inflammatory response (GO:0002676)2.50466849
147regulation of alpha-beta T cell activation (GO:0046634)2.50072954
148mitotic sister chromatid segregation (GO:0000070)2.48289988
149regulation of protein heterodimerization activity (GO:0043497)2.47802262
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47577966
151regulation of gene silencing by RNA (GO:0060966)2.45971218
152regulation of posttranscriptional gene silencing (GO:0060147)2.45971218
153regulation of gene silencing by miRNA (GO:0060964)2.45971218
154sulfate transmembrane transport (GO:1902358)2.45534246
155energy homeostasis (GO:0097009)2.45358027
156negative regulation of translational initiation (GO:0045947)2.44924544
157viral transcription (GO:0019083)2.44795252
158metaphase plate congression (GO:0051310)2.44598129
159positive regulation of gene expression, epigenetic (GO:0045815)2.41989765
160negative regulation of histone methylation (GO:0031061)2.40687089
161histone H2A acetylation (GO:0043968)2.40583591
162establishment of chromosome localization (GO:0051303)2.38708712
163peptidyl-arginine omega-N-methylation (GO:0035247)2.37304098
164nuclear pore organization (GO:0006999)2.36431027
165regulation of B cell receptor signaling pathway (GO:0050855)2.35969500
166nucleobase biosynthetic process (GO:0046112)2.35444631
167protein complex localization (GO:0031503)2.35303514
168maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35222148
169DNA replication-dependent nucleosome assembly (GO:0006335)2.35123503
170DNA replication-dependent nucleosome organization (GO:0034723)2.35123503
171sulfate transport (GO:0008272)2.34778110
172protein localization to chromosome (GO:0034502)2.34535961
173nuclear pore complex assembly (GO:0051292)2.33721065
174purine nucleobase biosynthetic process (GO:0009113)2.33034395
175pore complex assembly (GO:0046931)2.32239470
176lymphocyte apoptotic process (GO:0070227)2.30541873
177translational elongation (GO:0006414)2.29508081
178translational termination (GO:0006415)2.29348570
179regulation of tight junction assembly (GO:2000810)2.26986964
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.25883370
181pre-miRNA processing (GO:0031054)2.25804523
182snRNA metabolic process (GO:0016073)2.25713676
183mismatch repair (GO:0006298)2.22930477
184regulation of gene silencing (GO:0060968)2.22503971
185antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.22429076
186antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.22429076
187negative regulation of RNA splicing (GO:0033119)2.22262538
188tRNA methylation (GO:0030488)2.21746228
189spliceosomal snRNP assembly (GO:0000387)2.21638132
190ribonucleoprotein complex biogenesis (GO:0022613)2.21544920
191regulation of B cell differentiation (GO:0045577)2.21094693
192DNA duplex unwinding (GO:0032508)2.20405694
193DNA geometric change (GO:0032392)2.19810178
194negative regulation of telomerase activity (GO:0051974)2.19443808
195negative regulation of gene silencing (GO:0060969)2.18643521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93663286
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.02898030
3MYC_22102868_ChIP-Seq_BL_Human3.76541449
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.27127326
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.25793890
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22937765
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11756255
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.96845442
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85841131
10VDR_21846776_ChIP-Seq_THP-1_Human2.60086048
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55649042
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.47860121
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39440103
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.26478442
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18373709
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16832042
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14673213
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14135181
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08771585
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03533905
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03291987
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02686280
23BCL6_27268052_Chip-Seq_Bcells_Human1.98498005
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98033270
25CIITA_25753668_ChIP-Seq_RAJI_Human1.96253874
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.94235845
27* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93237637
28RUNX_20019798_ChIP-Seq_JUKART_Human1.89434022
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80975176
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80954749
31XRN2_22483619_ChIP-Seq_HELA_Human1.80016838
32BCOR_27268052_Chip-Seq_Bcells_Human1.77231708
33* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77021929
34P68_20966046_ChIP-Seq_HELA_Human1.74597366
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.73938671
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69012933
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66666086
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66342136
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.66088781
40* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64877946
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.63665065
42* KDM2B_26808549_Chip-Seq_DND41_Human1.63355883
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.63217910
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.62935536
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62547928
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61163662
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.60212251
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60142020
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58694452
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57569895
51AR_21909140_ChIP-Seq_LNCAP_Human1.56437540
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56199386
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.54955150
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53551722
55SPI1_23127762_ChIP-Seq_K562_Human1.51568456
56GABP_19822575_ChIP-Seq_HepG2_Human1.51469392
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51443804
58FOXP3_21729870_ChIP-Seq_TREG_Human1.51249459
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49016232
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48827455
61* GATA1_19941826_ChIP-Seq_K562_Human1.48588849
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48013408
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.47705865
64VDR_23849224_ChIP-Seq_CD4+_Human1.47220946
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.46336945
66SCL_19346495_ChIP-Seq_HPC-7_Human1.44880524
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44368565
68GATA1_22025678_ChIP-Seq_K562_Human1.43045176
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40562011
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40266813
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.39436249
72MAF_26560356_Chip-Seq_TH1_Human1.38630649
73KDM5A_27292631_Chip-Seq_BREAST_Human1.37757297
74SA1_27219007_Chip-Seq_Bcells_Human1.36797267
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36317162
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36301253
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34350908
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34202214
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33884861
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33751165
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33473700
82* CTCF_26484167_Chip-Seq_Bcells_Mouse1.33395229
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.32861300
84UTX_26944678_Chip-Seq_JUKART_Human1.32847512
85SPI1_23547873_ChIP-Seq_NB4_Human1.32519798
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31936312
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31691223
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30938196
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29751137
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29651148
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29573160
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28981311
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28036338
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27717575
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27691858
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27583060
97E2F1_20622854_ChIP-Seq_HELA_Human1.27582274
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27269143
99TTF2_22483619_ChIP-Seq_HELA_Human1.26620292
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26575847
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26562439
102PHF8_20622854_ChIP-Seq_HELA_Human1.25855977
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25387227
104MYB_26560356_Chip-Seq_TH1_Human1.25305679
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25277309
106VDR_24763502_ChIP-Seq_THP-1_Human1.24937619
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24717788
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24367199
109CTCF_20526341_ChIP-Seq_ESCs_Human1.23890337
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23685880
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.23524752
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23271210
113CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22874231
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22865383
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22083988
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21238418
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21224281
118THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21129972
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20931371
120* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20784093
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.20769432
122DCP1A_22483619_ChIP-Seq_HELA_Human1.20432153
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.20094322
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19505548
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19482952
126GABP_17652178_ChIP-ChIP_JURKAT_Human1.19184310
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18637797
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18358336
129MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18083838
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17419640
131* SMC4_20622854_ChIP-Seq_HELA_Human1.15762066
132P300_27268052_Chip-Seq_Bcells_Human1.15291986
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13966073
134GATA3_27048872_Chip-Seq_THYMUS_Human1.13707167
135CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13338036
136* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11438633
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11299413
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10481841
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09468551
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09424292
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08241649
142ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08121902
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06992706
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06382025
145MYB_26560356_Chip-Seq_TH2_Human1.02695845
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02265776
147HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01747271
148LXR_22292898_ChIP-Seq_THP-1_Human1.01619201
149MAF_26560356_Chip-Seq_TH2_Human1.01465539
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00726227
151* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00693019
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98752340
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.98355514
154RACK7_27058665_Chip-Seq_MCF-7_Human0.97307583
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95097759
156YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94318846
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90730190
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90650183
159TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89333230
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88942120
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88693025
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87212111
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86687005
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85194361
165MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84770522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.16750337
2MP0003303_peritoneal_inflammation4.08973920
3MP0005377_hearing/vestibular/ear_phenot3.87298240
4MP0003878_abnormal_ear_physiology3.87298240
5MP0003693_abnormal_embryo_hatching3.62502963
6MP0003436_decreased_susceptibility_to3.57910006
7MP0002148_abnormal_hypersensitivity_rea2.98722568
8MP0003111_abnormal_nucleus_morphology2.92377908
9MP0009785_altered_susceptibility_to2.89382236
10MP0006082_CNS_inflammation2.80604918
11MP0005025_abnormal_response_to2.78173949
12MP0003077_abnormal_cell_cycle2.76763768
13MP0004957_abnormal_blastocyst_morpholog2.68072978
14MP0002396_abnormal_hematopoietic_system2.66905548
15MP0010094_abnormal_chromosome_stability2.59858167
16MP0002419_abnormal_innate_immunity2.51404434
17MP0000678_abnormal_parathyroid_gland2.39435996
18MP0003646_muscle_fatigue2.36880399
19MP0005058_abnormal_lysosome_morphology2.30853784
20MP0010030_abnormal_orbit_morphology2.14153005
21MP0001533_abnormal_skeleton_physiology2.04204491
22MP0008057_abnormal_DNA_replication2.00130071
23MP0010155_abnormal_intestine_physiology1.97571775
24MP0000566_synostosis1.97453696
25MP0008007_abnormal_cellular_replicative1.95087325
26MP0001800_abnormal_humoral_immune1.94061158
27MP0002405_respiratory_system_inflammati1.88902691
28MP0002138_abnormal_hepatobiliary_system1.87753008
29MP0000490_abnormal_crypts_of1.83452598
30MP0001835_abnormal_antigen_presentation1.80554847
31MP0003172_abnormal_lysosome_physiology1.80103167
32MP0003123_paternal_imprinting1.76950065
33MP0009764_decreased_sensitivity_to1.75333010
34MP0004264_abnormal_extraembryonic_tissu1.74967944
35MP0003941_abnormal_skin_development1.70167761
36MP0004947_skin_inflammation1.65577403
37MP0008469_abnormal_protein_level1.61457561
38MP0003300_gastrointestinal_ulcer1.61224223
39MP0006292_abnormal_olfactory_placode1.59822775
40MP0005387_immune_system_phenotype1.58739298
41MP0001790_abnormal_immune_system1.58739298
42MP0002398_abnormal_bone_marrow1.57398629
43MP0003191_abnormal_cellular_cholesterol1.55357980
44MP0002933_joint_inflammation1.54931277
45MP0005464_abnormal_platelet_physiology1.53054356
46MP0000350_abnormal_cell_proliferation1.52089818
47MP0002452_abnormal_antigen_presenting1.48912328
48MP0008058_abnormal_DNA_repair1.46750605
49MP0003806_abnormal_nucleotide_metabolis1.45675537
50MP0002254_reproductive_system_inflammat1.43486478
51MP0000689_abnormal_spleen_morphology1.41515468
52MP0004510_myositis1.39975590
53MP0002139_abnormal_hepatobiliary_system1.38367547
54MP0001663_abnormal_digestive_system1.33630925
55MP0001730_embryonic_growth_arrest1.33371516
56MP0000685_abnormal_immune_system1.33355406
57MP0001672_abnormal_embryogenesis/_devel1.31410951
58MP0005380_embryogenesis_phenotype1.31410951
59MP0009333_abnormal_splenocyte_physiolog1.30665858
60MP0002722_abnormal_immune_system1.30238583
61MP0003075_altered_response_to1.30122390
62MP0000858_altered_metastatic_potential1.30119332
63MP0010352_gastrointestinal_tract_polyps1.28598972
64MP0000343_altered_response_to1.27194077
65MP0004808_abnormal_hematopoietic_stem1.27056261
66MP0003984_embryonic_growth_retardation1.26111894
67MP0000604_amyloidosis1.24851020
68MP0000716_abnormal_immune_system1.23239384
69MP0002429_abnormal_blood_cell1.21925226
70MP0002019_abnormal_tumor_incidence1.21531118
71MP0002420_abnormal_adaptive_immunity1.20824260
72MP0002088_abnormal_embryonic_growth/wei1.20605277
73MP0008932_abnormal_embryonic_tissue1.20399771
74MP0003566_abnormal_cell_adhesion1.20195227
75MP0002085_abnormal_embryonic_tissue1.19868783
76MP0005310_abnormal_salivary_gland1.19714286
77MP0003763_abnormal_thymus_physiology1.19178562
78MP0002249_abnormal_larynx_morphology1.19164224
79MP0001819_abnormal_immune_cell1.18354904
80MP0000703_abnormal_thymus_morphology1.14140141
81MP0001697_abnormal_embryo_size1.12149019
82MP0009697_abnormal_copulation1.08791377
83MP0002723_abnormal_immune_serum1.08679257
84MP0002086_abnormal_extraembryonic_tissu1.08231637
85MP0005257_abnormal_intraocular_pressure1.07413268
86MP0003183_abnormal_peptide_metabolism1.04897244
87MP0005360_urolithiasis1.04506483
88MP0001545_abnormal_hematopoietic_system1.04204405
89MP0005397_hematopoietic_system_phenotyp1.04204405
90MP0005076_abnormal_cell_differentiation1.03718212
91MP0002998_abnormal_bone_remodeling1.01878990
92MP0003786_premature_aging1.01571754
93MP0000465_gastrointestinal_hemorrhage1.00210524
94MP0009672_abnormal_birth_weight1.00199256
95MP0008004_abnormal_stomach_pH1.00069650
96MP0002653_abnormal_ependyma_morphology0.99277161
97MP0002277_abnormal_respiratory_mucosa0.96993217
98MP0002089_abnormal_postnatal_growth/wei0.96211652
99MP0005671_abnormal_response_to0.95955855
100MP0000313_abnormal_cell_death0.95851764
101MP0001119_abnormal_female_reproductive0.95255010
102MP0002084_abnormal_developmental_patter0.94658105
103MP0005390_skeleton_phenotype0.93859982
104MP0005075_abnormal_melanosome_morpholog0.93807485
105MP0002080_prenatal_lethality0.93014221
106MP0003656_abnormal_erythrocyte_physiolo0.92517593
107MP0002136_abnormal_kidney_physiology0.91981609
108MP0003943_abnormal_hepatobiliary_system0.91235445
109MP0003448_altered_tumor_morphology0.91139149
110MP0005381_digestive/alimentary_phenotyp0.90070329
111MP0004381_abnormal_hair_follicle0.88802008
112MP0004130_abnormal_muscle_cell0.86828407
113MP0003279_aneurysm0.86357026
114MP0003879_abnormal_hair_cell0.84978027
115MP0001849_ear_inflammation0.84753862
116MP0001764_abnormal_homeostasis0.83238682
117MP0002132_abnormal_respiratory_system0.83066661
118MP0004197_abnormal_fetal_growth/weight/0.83050696
119MP0005166_decreased_susceptibility_to0.81917164
120MP0005083_abnormal_biliary_tract0.81002200
121MP0001853_heart_inflammation0.80417379
122MP0002210_abnormal_sex_determination0.80318680
123MP0000681_abnormal_thyroid_gland0.79071354
124MP0009763_increased_sensitivity_to0.78839144
125MP0000477_abnormal_intestine_morphology0.78355192
126MP0001293_anophthalmia0.78020257
127MP0009278_abnormal_bone_marrow0.77474114
128MP0001542_abnormal_bone_strength0.77193523
129MP0009053_abnormal_anal_canal0.77157693
130MP0003121_genomic_imprinting0.76214362
131MP0005670_abnormal_white_adipose0.75276250
132MP0005319_abnormal_enzyme/_coenzyme0.74972477
133MP0002113_abnormal_skeleton_development0.74376091
134MP0005535_abnormal_body_temperature0.74110547
135MP0009643_abnormal_urine_homeostasis0.73492002
136MP0009840_abnormal_foam_cell0.73232114
137MP0005451_abnormal_body_composition0.72793691
138MP0001873_stomach_inflammation0.72452817
139MP0005365_abnormal_bile_salt0.72256162
140MP0005167_abnormal_blood-brain_barrier0.71755976
141MP0003705_abnormal_hypodermis_morpholog0.71370366
142MP0001986_abnormal_taste_sensitivity0.71144849
143MP0004858_abnormal_nervous_system0.70880833
144MP0003186_abnormal_redox_activity0.70640304
145MP0002938_white_spotting0.70587224
146MP0000609_abnormal_liver_physiology0.70483010
147MP0000015_abnormal_ear_pigmentation0.69525875
148MP0002932_abnormal_joint_morphology0.69363946
149MP0005621_abnormal_cell_physiology0.68796714
150MP0000249_abnormal_blood_vessel0.67913633
151MP0005023_abnormal_wound_healing0.66829034
152MP0002163_abnormal_gland_morphology0.66641439
153MP0005334_abnormal_fat_pad0.66236032
154MP0003935_abnormal_craniofacial_develop0.65863700
155MP0002118_abnormal_lipid_homeostasis0.65647599
156MP0003866_abnormal_defecation0.65564017
157MP0000049_abnormal_middle_ear0.65552681
158MP0008260_abnormal_autophagy0.65304151
159MP0005000_abnormal_immune_tolerance0.65122191
160MP0010307_abnormal_tumor_latency0.64905538
161MP0001845_abnormal_inflammatory_respons0.64865774
162MP0003195_calcinosis0.64740442
163MP0001145_abnormal_male_reproductive0.64624217
164MP0005636_abnormal_mineral_homeostasis0.64585880
165MP0010329_abnormal_lipoprotein_level0.64315700

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.72424751
2Retrobulbar optic neuritis (HP:0100654)4.55876120
3Optic neuritis (HP:0100653)4.55876120
4Eczematoid dermatitis (HP:0000976)4.37841373
5Stomatitis (HP:0010280)4.31051000
6Abnormality of liposaccharide metabolism (HP:0010968)4.29790339
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.29790339
8Abnormality of glycolipid metabolism (HP:0010969)4.29790339
9Abnormality of macrophages (HP:0004311)4.24190810
10Recurrent abscess formation (HP:0002722)4.05164729
11Elevated erythrocyte sedimentation rate (HP:0003565)4.03008231
12Unilateral renal agenesis (HP:0000122)3.96007791
13Systemic lupus erythematosus (HP:0002725)3.79837283
14Agammaglobulinemia (HP:0004432)3.75538767
15Recurrent bacterial skin infections (HP:0005406)3.68935647
16IgM deficiency (HP:0002850)3.61501982
17Chronic otitis media (HP:0000389)3.58643169
18Increased cerebral lipofuscin (HP:0011813)3.54595083
19Reticulocytopenia (HP:0001896)3.48680946
20Alopecia of scalp (HP:0002293)3.48127330
21Keratoconjunctivitis sicca (HP:0001097)3.44171399
22Bilateral sensorineural hearing impairment (HP:0008619)3.38058958
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.37752960
24Recurrent fungal infections (HP:0002841)3.34985017
25Encephalitis (HP:0002383)3.34505311
26Keratoconjunctivitis (HP:0001096)3.34422297
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.25019473
28Vacuolated lymphocytes (HP:0001922)3.23472205
29Recurrent gram-negative bacterial infections (HP:0005420)3.21887258
30Parakeratosis (HP:0001036)3.21753575
31Pustule (HP:0200039)3.21333891
32Hypochromic anemia (HP:0001931)3.20578462
33Obstructive lung disease (HP:0006536)3.16369186
34Chronic obstructive pulmonary disease (HP:0006510)3.16369186
35Increased serum ferritin (HP:0003281)3.15802471
36Increased IgM level (HP:0003496)3.15394015
37Autoimmune thrombocytopenia (HP:0001973)3.08506313
38Dysostosis multiplex (HP:0000943)3.08082274
39Chromsome breakage (HP:0040012)3.07817637
40Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07114051
41Abnormality of the heme biosynthetic pathway (HP:0010472)3.06405404
42Small epiphyses (HP:0010585)3.01583828
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96725251
44Gastrointestinal stroma tumor (HP:0100723)2.92821801
45Cellulitis (HP:0100658)2.92130571
46Abnormality of iron homeostasis (HP:0011031)2.90562666
47Vasculitis (HP:0002633)2.90462387
48Follicular hyperkeratosis (HP:0007502)2.88679467
49Pulmonary infiltrates (HP:0002113)2.87030133
50Petechiae (HP:0000967)2.86793701
51Abnormality of the fingertips (HP:0001211)2.75871851
52T lymphocytopenia (HP:0005403)2.74003003
53Abnormality of T cell number (HP:0011839)2.73968641
54Gastrointestinal infarctions (HP:0005244)2.72179880
55Lymphopenia (HP:0001888)2.71921313
56Abnormality of transition element cation homeostasis (HP:0011030)2.71119776
57Colitis (HP:0002583)2.69578424
58Ectopic kidney (HP:0000086)2.65821580
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.65668428
60Hypochromic microcytic anemia (HP:0004840)2.62772724
61Cheilitis (HP:0100825)2.60489866
62Hemoptysis (HP:0002105)2.58859469
63Increased IgE level (HP:0003212)2.58666905
64Prolonged bleeding time (HP:0003010)2.55741106
65Leukocytosis (HP:0001974)2.55151567
66Malnutrition (HP:0004395)2.55105852
67Microcytic anemia (HP:0001935)2.54740195
68Recurrent skin infections (HP:0001581)2.54457231
69Gingivitis (HP:0000230)2.52967326
70Abnormality of T cells (HP:0002843)2.52582132
71Loss of speech (HP:0002371)2.50492916
72Recurrent pneumonia (HP:0006532)2.48250322
73Panhypogammaglobulinemia (HP:0003139)2.47630907
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46932747
75Gastrointestinal inflammation (HP:0004386)2.46837024
76Recurrent sinusitis (HP:0011108)2.44652295
77Recurrent cutaneous fungal infections (HP:0011370)2.41238634
78Chronic mucocutaneous candidiasis (HP:0002728)2.41238634
79Recurrent bronchitis (HP:0002837)2.40930879
80Recurrent lower respiratory tract infections (HP:0002783)2.38092173
81Spontaneous hematomas (HP:0007420)2.34590395
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34051737
83Carpal bone hypoplasia (HP:0001498)2.33462076
84Abnormality of polysaccharide metabolism (HP:0011012)2.32999348
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32999348
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32999348
87Aplasia/Hypoplasia of the patella (HP:0006498)2.32257776
88Blepharitis (HP:0000498)2.32014828
89Patellar aplasia (HP:0006443)2.31483436
90Purpura (HP:0000979)2.29312266
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28268041
92Absent eyelashes (HP:0000561)2.27264037
93Anorexia (HP:0002039)2.26740302
94Autoimmune hemolytic anemia (HP:0001890)2.25804125
95Thrombocytosis (HP:0001894)2.24167178
96Inflammation of the large intestine (HP:0002037)2.24131987
97Pulmonary embolism (HP:0002204)2.24031115
98Abnormality of the renal collecting system (HP:0004742)2.22933030
99Emphysema (HP:0002097)2.22743546
100Selective tooth agenesis (HP:0001592)2.20992995
101Severe combined immunodeficiency (HP:0004430)2.19379356
102Hematochezia (HP:0002573)2.19057413
103Epistaxis (HP:0000421)2.19024990
104Absent epiphyses (HP:0010577)2.15199937
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15199937
106Hypergammaglobulinemia (HP:0010702)2.13441817
107Meckel diverticulum (HP:0002245)2.12720933
108Abnormality of carpal bone ossification (HP:0006257)2.11750849
109Absent thumb (HP:0009777)2.11622721
110Duplicated collecting system (HP:0000081)2.11575659
111Episodic fever (HP:0001954)2.10177530
112Abnormality of T cell physiology (HP:0011840)2.10128885
113Abnormal hemoglobin (HP:0011902)2.09955221
114Urticaria (HP:0001025)2.09676085
115Abnormality of the intervertebral disk (HP:0005108)2.08045891
116Abnormality of the ileum (HP:0001549)2.07833812
117Abnormality of the pleura (HP:0002103)2.06884935
118Abnormality of dental color (HP:0011073)2.06265209
119Clubbing of toes (HP:0100760)2.04369592
120Myositis (HP:0100614)2.04164988
121Flattened epiphyses (HP:0003071)2.03851619
122Acne (HP:0001061)2.03639185
123Aplasia/Hypoplasia of the uvula (HP:0010293)2.03537516
124Ulnar bowing (HP:0003031)2.03346301
125Gangrene (HP:0100758)2.03015498
126Meningitis (HP:0001287)2.02044519
127Polyneuropathy (HP:0001271)2.00932307
128Granulocytopenia (HP:0001913)2.00373534
129Joint swelling (HP:0001386)1.99755558
130Abnormality of B cell number (HP:0010975)1.98355661
131B lymphocytopenia (HP:0010976)1.98355661
132Vertebral clefting (HP:0008428)1.97213466
133Abnormality of the pericardium (HP:0001697)1.96169796
134IgA deficiency (HP:0002720)1.95367979
135Abnormal ossification of hand bones (HP:0005921)1.94538008
136Hypertriglyceridemia (HP:0002155)1.93968147
137Chronic sinusitis (HP:0011109)1.93276648
138Arterial thrombosis (HP:0004420)1.93134072
139Leukopenia (HP:0001882)1.93105022
140Abnormality of chromosome stability (HP:0003220)1.92771516
141Mesangial abnormality (HP:0001966)1.92369575
142Combined immunodeficiency (HP:0005387)1.91638433
143Urinary glycosaminoglycan excretion (HP:0003541)1.91455056
144Mucopolysacchariduria (HP:0008155)1.91455056
145Arthralgia (HP:0002829)1.90420569
146Hypergonadotropic hypogonadism (HP:0000815)1.90200861
147IgG deficiency (HP:0004315)1.89350645
148Glomerulopathy (HP:0100820)1.89319209
149Axonal loss (HP:0003447)1.88503391
150Birth length less than 3rd percentile (HP:0003561)1.87431202
151Vertigo (HP:0002321)1.87240944
152Hepatosplenomegaly (HP:0001433)1.86956494
153Abnormality of the preputium (HP:0100587)1.86499244
154Abnormality of DNA repair (HP:0003254)1.84650172
155Shawl scrotum (HP:0000049)1.81758469
156Bowed forearm bones (HP:0003956)1.81297336
157Bowing of the arm (HP:0006488)1.81297336
158Papilloma (HP:0012740)1.81193291
159Verrucae (HP:0200043)1.81193291
160Mediastinal lymphadenopathy (HP:0100721)1.79158860
161Flat capital femoral epiphysis (HP:0003370)1.78988068
162Long eyelashes (HP:0000527)1.78965182
163Abnormality of pyrimidine metabolism (HP:0004353)1.77247987
164Recurrent viral infections (HP:0004429)1.76586653
165Abnormality of the carotid arteries (HP:0005344)1.76328000
166Microretrognathia (HP:0000308)1.76166639
167Abnormal hand bone ossification (HP:0010660)1.73268860
168Renal duplication (HP:0000075)1.70863008
169Short femoral neck (HP:0100864)1.68606400
170Tetany (HP:0001281)1.67808425
171Rough bone trabeculation (HP:0100670)1.66033543
172Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64815877
173Abnormality of the epiphysis of the femoral head (HP:0010574)1.64764481
174Breast hypoplasia (HP:0003187)1.63796216
175Abnormality of femoral epiphyses (HP:0006499)1.62784475
176Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.62784475
177Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.62773115
178Absent radius (HP:0003974)1.62362640
179Genu recurvatum (HP:0002816)1.62276857
180Hypoalbuminemia (HP:0003073)1.62002731
181Abnormal albumin level (HP:0012116)1.62002731
182Optic nerve coloboma (HP:0000588)1.60636718
183Osteomyelitis (HP:0002754)1.57990303
184Abnormal tarsal ossification (HP:0008369)1.56249373
185Absent forearm bone (HP:0003953)1.56235386
186Aplasia involving forearm bones (HP:0009822)1.56235386
187Rectal prolapse (HP:0002035)1.53121264
188Fatigue (HP:0012378)1.52861371
189Lymphoma (HP:0002665)1.52683672
190Metaphyseal cupping (HP:0003021)1.51976901
191Abnormality of the femoral head (HP:0003368)1.51646529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.54801830
2MAP4K13.41315470
3EEF2K3.40885117
4SIK13.12138213
5TXK2.95801724
6ERN12.58493907
7CDK122.47814244
8SIK22.43229385
9CDK82.36263340
10STK38L2.34672044
11LATS12.29368981
12RIPK42.27706679
13MARK32.25232114
14EPHA22.23438186
15TNK22.18203170
16TRIB32.10171009
17IRAK42.08690730
18FES2.04447998
19CSK2.04025166
20NEK21.99433314
21FLT31.93299060
22LATS21.91454492
23CDC71.85561314
24IKBKE1.81338313
25PAK41.79088864
26CSF1R1.78433871
27MAPKAPK31.71542350
28BRSK21.69577594
29MAP3K141.68285371
30STK101.67370813
31RPS6KB21.62741852
32CDK71.60453057
33ADRBK21.54212065
34RPS6KA41.53665282
35BUB11.49674413
36CDC42BPA1.47434929
37PRPF4B1.40195964
38GRK71.38080009
39CHEK21.33156690
40SCYL21.32431324
41TLK11.30839582
42NME21.30835262
43CDK41.26454603
44TTK1.25958535
45LRRK21.21404356
46GRK61.21261964
47LCK1.20624682
48MAP3K101.20230531
49KIT1.17523739
50BTK1.14684127
51PIM11.11153582
52JAK31.08982389
53TESK21.08015253
54HCK1.07405712
55TAOK11.03747709
56MUSK1.01716897
57ATR1.01374858
58EIF2AK11.01374350
59MAPK111.00195179
60BRSK11.00137919
61MAP3K10.99725195
62FGR0.98806356
63WEE10.96227739
64MAP2K60.95595484
65PLK40.95378357
66BCKDK0.94611425
67TGFBR20.93855114
68MAP2K20.92263634
69BLK0.92249674
70MAP3K80.91947856
71EPHB10.90806924
72DDR20.89469035
73IRAK30.88996590
74STK30.87894659
75PIM20.84383670
76NLK0.83754146
77HIPK20.82254311
78PLK10.81438621
79TYRO30.80340050
80ACVR1B0.80015227
81ITK0.78200963
82RPS6KC10.77604886
83RPS6KL10.77604886
84CAMKK20.77518738
85ABL20.77075716
86BRAF0.76999488
87TEC0.74676609
88MAP3K60.73944705
89PKN20.73527801
90JAK10.72404764
91SYK0.71893546
92NEK10.71118094
93WNK40.69667313
94JAK20.68845979
95EIF2AK30.68746335
96PTK60.67173092
97PRKCQ0.66176663
98MAP3K110.65449583
99MAP2K30.65313827
100MATK0.64915697
101PRKCH0.64555435
102TESK10.63943393
103TGFBR10.63035151
104SMG10.62936158
105GRK10.62828819
106AURKB0.61211920
107TAOK20.60590267
108RPS6KA20.59730573
109* CHEK10.59388994
110CAMKK10.58762749
111PINK10.58503518
112KDR0.58279175
113LIMK10.58118393
114PRKCI0.57896383
115ZAP700.57630383
116PDK10.56961977
117SRPK10.56776120
118DYRK1B0.56386122
119DYRK30.55292922
120MARK20.54203698
121DAPK20.53282796
122PASK0.52861445
123PDPK10.52133285
124VRK10.52062928
125MAPK40.50947442
126CLK10.50746671
127RIPK10.50386151
128MAPKAPK20.49428749
129BRD40.49311754
130CDK90.48936184
131SGK20.48897211
132MAP3K30.48145045
133IRAK10.47861566
134TYK20.47707789
135MAP3K130.47587476
136ADRBK10.46961828
137CHUK0.45831626
138TIE10.44873376
139MTOR0.44615913
140FGFR40.44390540
141LYN0.43769287
142PRKG20.42794888
143CDK20.42768900
144AKT20.42499142
145TAOK30.42423065
146SGK30.41003110
147IKBKB0.40397551
148STK240.39958434
149MAPK70.39746175
150TBK10.36640375
151MAPK120.36004652
152ICK0.35746992
153PRKD20.33507255
154ATM0.32382174
155CAMK1D0.31381506
156ZAK0.29230878
157RPS6KA60.29211050
158CAMK40.28851953

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91607020
2Base excision repair_Homo sapiens_hsa034103.24870778
3Allograft rejection_Homo sapiens_hsa053303.24228721
4Mismatch repair_Homo sapiens_hsa034303.09553018
5Graft-versus-host disease_Homo sapiens_hsa053323.01338507
6Autoimmune thyroid disease_Homo sapiens_hsa053202.80880805
7Staphylococcus aureus infection_Homo sapiens_hsa051502.78148363
8Homologous recombination_Homo sapiens_hsa034402.72002361
9Primary immunodeficiency_Homo sapiens_hsa053402.65209147
10Malaria_Homo sapiens_hsa051442.62914489
11Cell cycle_Homo sapiens_hsa041102.47591658
12Asthma_Homo sapiens_hsa053102.44149615
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29248068
14Osteoclast differentiation_Homo sapiens_hsa043802.27421426
15Type I diabetes mellitus_Homo sapiens_hsa049402.11763364
16Spliceosome_Homo sapiens_hsa030402.08594390
17RNA transport_Homo sapiens_hsa030132.04347569
18Ribosome_Homo sapiens_hsa030102.04135657
19Rheumatoid arthritis_Homo sapiens_hsa053231.92420164
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88610304
21B cell receptor signaling pathway_Homo sapiens_hsa046621.84345138
22Fanconi anemia pathway_Homo sapiens_hsa034601.81433591
23One carbon pool by folate_Homo sapiens_hsa006701.80776908
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.75903433
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74562679
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69214000
27Nucleotide excision repair_Homo sapiens_hsa034201.68419284
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66125897
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64262574
30RNA degradation_Homo sapiens_hsa030181.63618849
31RNA polymerase_Homo sapiens_hsa030201.63505858
32Lysosome_Homo sapiens_hsa041421.61562391
33African trypanosomiasis_Homo sapiens_hsa051431.60869443
34Pyrimidine metabolism_Homo sapiens_hsa002401.59572114
35p53 signaling pathway_Homo sapiens_hsa041151.59492475
36T cell receptor signaling pathway_Homo sapiens_hsa046601.52825693
37TNF signaling pathway_Homo sapiens_hsa046681.50706987
38Pertussis_Homo sapiens_hsa051331.43252340
39Viral myocarditis_Homo sapiens_hsa054161.42338432
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.38764271
41Non-homologous end-joining_Homo sapiens_hsa034501.37601650
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31257777
43Herpes simplex infection_Homo sapiens_hsa051681.31196890
44Basal transcription factors_Homo sapiens_hsa030221.30375402
45Sulfur relay system_Homo sapiens_hsa041221.29884802
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.28442524
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26550950
48Legionellosis_Homo sapiens_hsa051341.25796152
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.23483917
50HTLV-I infection_Homo sapiens_hsa051661.16784188
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15861311
52Antigen processing and presentation_Homo sapiens_hsa046121.15502415
53N-Glycan biosynthesis_Homo sapiens_hsa005101.14249594
54Small cell lung cancer_Homo sapiens_hsa052221.13176853
55Pentose phosphate pathway_Homo sapiens_hsa000301.11608242
56Folate biosynthesis_Homo sapiens_hsa007901.08991602
57Shigellosis_Homo sapiens_hsa051311.06650082
58Acute myeloid leukemia_Homo sapiens_hsa052211.06621018
59Lysine degradation_Homo sapiens_hsa003101.06392449
60Notch signaling pathway_Homo sapiens_hsa043301.03860000
61Epstein-Barr virus infection_Homo sapiens_hsa051691.02754226
62Adipocytokine signaling pathway_Homo sapiens_hsa049201.00103015
63Chemokine signaling pathway_Homo sapiens_hsa040620.99953866
64Hematopoietic cell lineage_Homo sapiens_hsa046400.98888642
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98346681
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97290040
67Galactose metabolism_Homo sapiens_hsa000520.96590645
68MicroRNAs in cancer_Homo sapiens_hsa052060.96219350
69Thyroid cancer_Homo sapiens_hsa052160.95476665
70Chronic myeloid leukemia_Homo sapiens_hsa052200.95355535
71Arachidonic acid metabolism_Homo sapiens_hsa005900.94960408
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92993250
73Hepatitis C_Homo sapiens_hsa051600.92853932
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92768725
75Proteasome_Homo sapiens_hsa030500.87431124
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86365332
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85369632
78Pancreatic cancer_Homo sapiens_hsa052120.85137740
79Bladder cancer_Homo sapiens_hsa052190.83476843
80Apoptosis_Homo sapiens_hsa042100.79113004
81mRNA surveillance pathway_Homo sapiens_hsa030150.78673759
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78322554
83Phagosome_Homo sapiens_hsa041450.78058464
84Collecting duct acid secretion_Homo sapiens_hsa049660.77936428
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76697279
86Sulfur metabolism_Homo sapiens_hsa009200.75790538
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75508109
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74982093
89Salmonella infection_Homo sapiens_hsa051320.74937506
90Measles_Homo sapiens_hsa051620.74551828
91Hepatitis B_Homo sapiens_hsa051610.74258892
92Linoleic acid metabolism_Homo sapiens_hsa005910.73136052
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.71604150
94Hippo signaling pathway_Homo sapiens_hsa043900.70637510
95Fat digestion and absorption_Homo sapiens_hsa049750.70590706
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68189829
97Selenocompound metabolism_Homo sapiens_hsa004500.67143533
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66607324
99Vitamin digestion and absorption_Homo sapiens_hsa049770.63594972
100Viral carcinogenesis_Homo sapiens_hsa052030.62823244
101Non-small cell lung cancer_Homo sapiens_hsa052230.62623053
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.62580583
103PPAR signaling pathway_Homo sapiens_hsa033200.62414396
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62191138
105Basal cell carcinoma_Homo sapiens_hsa052170.62091982
106Other glycan degradation_Homo sapiens_hsa005110.61781376
107Ether lipid metabolism_Homo sapiens_hsa005650.60189862
108Adherens junction_Homo sapiens_hsa045200.60154840
109HIF-1 signaling pathway_Homo sapiens_hsa040660.60060344
110Colorectal cancer_Homo sapiens_hsa052100.59963218
111Influenza A_Homo sapiens_hsa051640.59488344
112Glycerolipid metabolism_Homo sapiens_hsa005610.56958771
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56824384
114Toxoplasmosis_Homo sapiens_hsa051450.56037349
115Renin-angiotensin system_Homo sapiens_hsa046140.55114175
116Biosynthesis of amino acids_Homo sapiens_hsa012300.55072650
117TGF-beta signaling pathway_Homo sapiens_hsa043500.55056087
118Hedgehog signaling pathway_Homo sapiens_hsa043400.54711616
119Fructose and mannose metabolism_Homo sapiens_hsa000510.54516810
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54490594
121Protein digestion and absorption_Homo sapiens_hsa049740.53983129
122Leishmaniasis_Homo sapiens_hsa051400.53597541
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.53318800
124Prostate cancer_Homo sapiens_hsa052150.53065982
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51954692
126Pathways in cancer_Homo sapiens_hsa052000.51831337
127Purine metabolism_Homo sapiens_hsa002300.51152543
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.51035224
129VEGF signaling pathway_Homo sapiens_hsa043700.48596404
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48244928
131Melanoma_Homo sapiens_hsa052180.47921777
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.47813264
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47308891
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47292278
135Arginine and proline metabolism_Homo sapiens_hsa003300.46220975
136Prion diseases_Homo sapiens_hsa050200.45107342
137Prolactin signaling pathway_Homo sapiens_hsa049170.43918393
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42659357
139Glutathione metabolism_Homo sapiens_hsa004800.42183006
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42058853
141ABC transporters_Homo sapiens_hsa020100.41732864
142FoxO signaling pathway_Homo sapiens_hsa040680.40625727
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40306091
144Complement and coagulation cascades_Homo sapiens_hsa046100.39813261
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39644975
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39434380
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39272473
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38637639
149Platelet activation_Homo sapiens_hsa046110.38372854
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38299600
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37608209
152mTOR signaling pathway_Homo sapiens_hsa041500.36542006
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36440811
154Endocytosis_Homo sapiens_hsa041440.36392621
155Tuberculosis_Homo sapiens_hsa051520.36101699
156Tryptophan metabolism_Homo sapiens_hsa003800.35867324
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34438688
158Mineral absorption_Homo sapiens_hsa049780.31706082
159Insulin resistance_Homo sapiens_hsa049310.29069246
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.23526055
161Sphingolipid metabolism_Homo sapiens_hsa006000.21324258
162Systemic lupus erythematosus_Homo sapiens_hsa053220.21066433

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