PRR35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.16286228
2synaptic vesicle maturation (GO:0016188)8.11768436
3glutamate secretion (GO:0014047)7.45798682
4synaptic vesicle exocytosis (GO:0016079)7.42190810
5cellular potassium ion homeostasis (GO:0030007)7.08960602
6positive regulation of synapse maturation (GO:0090129)6.96202682
7cerebellar granule cell differentiation (GO:0021707)6.80238916
8sodium ion export (GO:0071436)6.79744930
9regulation of short-term neuronal synaptic plasticity (GO:0048172)6.59266883
10regulation of synaptic vesicle exocytosis (GO:2000300)6.57093044
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.48955896
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.36836673
13neurotransmitter secretion (GO:0007269)6.34739915
14vocalization behavior (GO:0071625)5.69958378
15regulation of synapse maturation (GO:0090128)5.58978034
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54105250
17regulation of synaptic vesicle transport (GO:1902803)5.52961083
18locomotory exploration behavior (GO:0035641)5.38676427
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.34437719
20neuronal action potential propagation (GO:0019227)5.18839523
21regulation of neuronal synaptic plasticity (GO:0048168)5.09191586
22neurotransmitter transport (GO:0006836)5.00554608
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.86352901
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.85333190
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.83396183
26postsynaptic membrane organization (GO:0001941)4.81269110
27potassium ion homeostasis (GO:0055075)4.71778845
28neurotransmitter-gated ion channel clustering (GO:0072578)4.71212556
29positive regulation of membrane potential (GO:0045838)4.62236288
30auditory behavior (GO:0031223)4.60495615
31potassium ion import (GO:0010107)4.55031550
32regulation of neurotransmitter levels (GO:0001505)4.47384226
33cellular sodium ion homeostasis (GO:0006883)4.45824844
34dendritic spine morphogenesis (GO:0060997)4.44625910
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.40568663
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38823302
37exploration behavior (GO:0035640)4.34447262
38cerebellar Purkinje cell differentiation (GO:0021702)4.30397352
39neuromuscular process controlling balance (GO:0050885)4.27301586
40axon ensheathment in central nervous system (GO:0032291)4.21998500
41central nervous system myelination (GO:0022010)4.21998500
42L-amino acid import (GO:0043092)4.19641225
43regulation of excitatory postsynaptic membrane potential (GO:0060079)4.19538396
44positive regulation of dendritic spine development (GO:0060999)4.18626545
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17396930
46cell communication by electrical coupling (GO:0010644)4.16759498
47regulation of vesicle fusion (GO:0031338)4.11646696
48regulation of ARF protein signal transduction (GO:0032012)4.09079805
49regulation of glutamate receptor signaling pathway (GO:1900449)4.07758019
50regulation of synapse structural plasticity (GO:0051823)4.03881599
51glutamate receptor signaling pathway (GO:0007215)4.02123962
52synaptic transmission, glutamatergic (GO:0035249)3.99488680
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.97412682
54long-term memory (GO:0007616)3.96980684
55cell differentiation in hindbrain (GO:0021533)3.95934236
56synaptic vesicle endocytosis (GO:0048488)3.89084194
57layer formation in cerebral cortex (GO:0021819)3.88277883
58neuronal ion channel clustering (GO:0045161)3.87700966
59gamma-aminobutyric acid transport (GO:0015812)3.87550575
60protein localization to synapse (GO:0035418)3.85612933
61amino acid import (GO:0043090)3.81554023
62regulation of neurotransmitter secretion (GO:0046928)3.81109550
63neuromuscular process controlling posture (GO:0050884)3.80865798
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.79904872
65regulation of synaptic plasticity (GO:0048167)3.79890865
66regulation of postsynaptic membrane potential (GO:0060078)3.79360074
67neuron cell-cell adhesion (GO:0007158)3.77763089
68neurotransmitter uptake (GO:0001504)3.69197665
69mechanosensory behavior (GO:0007638)3.66204929
70neuron-neuron synaptic transmission (GO:0007270)3.65543031
71proline transport (GO:0015824)3.65206339
72cochlea development (GO:0090102)3.64723171
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.56580781
74response to auditory stimulus (GO:0010996)3.52962876
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.49555724
76regulation of voltage-gated calcium channel activity (GO:1901385)3.45120090
77membrane depolarization during action potential (GO:0086010)3.44839561
78regulation of neurotransmitter transport (GO:0051588)3.43787303
79membrane depolarization (GO:0051899)3.40784256
80establishment of synaptic vesicle localization (GO:0097480)3.37644459
81synaptic vesicle transport (GO:0048489)3.37644459
82cerebellar Purkinje cell layer development (GO:0021680)3.35213739
83regulation of dendritic spine morphogenesis (GO:0061001)3.32028092
84signal release (GO:0023061)3.22172639
85transmission of nerve impulse (GO:0019226)3.18102308
86positive regulation of dendrite development (GO:1900006)3.15977382
87dendritic spine organization (GO:0097061)3.15353811
88negative regulation of catenin import into nucleus (GO:0035414)3.13953132
89regulation of dendritic spine development (GO:0060998)3.13877996
90long-term synaptic potentiation (GO:0060291)3.13777463
91regulation of synaptic transmission (GO:0050804)3.12891428
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11826795
93neuromuscular process (GO:0050905)3.11582073
94cell communication involved in cardiac conduction (GO:0086065)3.11146637
95positive regulation of vesicle fusion (GO:0031340)3.10154923
96synaptic transmission (GO:0007268)3.10034924
97acidic amino acid transport (GO:0015800)3.09883448
98vesicle docking involved in exocytosis (GO:0006904)3.09511553
99social behavior (GO:0035176)3.09038347
100intraspecies interaction between organisms (GO:0051703)3.09038347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12126334
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.83539953
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.44274957
4REST_21632747_ChIP-Seq_MESCs_Mouse3.37040381
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.34486271
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30071144
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.27427369
8DROSHA_22980978_ChIP-Seq_HELA_Human3.22854538
9RARB_27405468_Chip-Seq_BRAIN_Mouse3.15065181
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12464199
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97396064
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92655488
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91702882
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91702882
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.89220166
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.81755967
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.75209548
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.62391414
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.58223631
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.57735255
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.48737595
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48647352
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45092691
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38993819
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34990118
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21225493
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.14111230
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.12918217
29DNAJC2_21179169_ChIP-ChIP_NT2_Human2.11678472
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.11572793
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.11167810
32ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04609857
33KDM2B_26808549_Chip-Seq_K562_Human2.02681743
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83701001
35LXR_22292898_ChIP-Seq_THP-1_Human1.78139777
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77371244
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69580497
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65266360
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58578132
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.55294719
41GBX2_23144817_ChIP-Seq_PC3_Human1.50270541
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49859910
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48383055
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.42774051
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40847751
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37004481
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35180356
48CTCF_27219007_Chip-Seq_Bcells_Human1.35146577
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25703192
50SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23340750
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22525972
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.22403568
53SMC4_20622854_ChIP-Seq_HELA_Human1.21910571
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18893246
55OCT4_19829295_ChIP-Seq_ESCs_Human1.17842816
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14851622
57P68_20966046_ChIP-Seq_HELA_Human1.14286743
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.13793711
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.10530543
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10204991
61AR_19668381_ChIP-Seq_PC3_Human1.08703622
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07869938
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07340427
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07308221
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07043433
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99512525
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98480011
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97215567
69SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96900748
70CREB1_26743006_Chip-Seq_LNCaP_Human0.96636412
71SMAD4_21741376_ChIP-Seq_ESCs_Human0.95448111
72KDM2B_26808549_Chip-Seq_DND41_Human0.94812617
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93382651
74TP53_20018659_ChIP-ChIP_R1E_Mouse0.92574368
75DPY_21335234_ChIP-Seq_ESCs_Mouse0.92370685
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92260047
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92222917
78RNF2_27304074_Chip-Seq_NSC_Mouse0.91088160
79NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89414673
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88557118
81KLF4_19829295_ChIP-Seq_ESCs_Human0.87098565
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86829611
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86471264
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86186410
85MYC_19915707_ChIP-ChIP_AK7_Human0.82850408
86AR_21572438_ChIP-Seq_LNCaP_Human0.82846997
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82803527
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.82324518
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82223944
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81727274
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80711926
92TP53_23651856_ChIP-Seq_MEFs_Mouse0.79503399
93EGR1_19032775_ChIP-ChIP_M12_Human0.79439454
94STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79389075
95MYC_27129775_Chip-Seq_CORNEA_Mouse0.78456316
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.78449116
97TRIM28_21343339_ChIP-Seq_HEK293_Human0.78134674
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77732761
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77508580
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76895587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20117727
2MP0003880_abnormal_central_pattern5.43248023
3MP0005423_abnormal_somatic_nervous4.61858975
4MP0004270_analgesia4.44530596
5MP0003635_abnormal_synaptic_transmissio4.05842726
6MP0002064_seizures3.72366096
7MP0009745_abnormal_behavioral_response3.40077644
8MP0009046_muscle_twitch3.36611968
9MP0002063_abnormal_learning/memory/cond3.19439325
10MP0008569_lethality_at_weaning3.10571514
11MP0002734_abnormal_mechanical_nocicepti3.04131045
12MP0001486_abnormal_startle_reflex3.03014581
13MP0002272_abnormal_nervous_system2.99350645
14MP0001968_abnormal_touch/_nociception2.91488581
15MP0002572_abnormal_emotion/affect_behav2.48747706
16MP0001501_abnormal_sleep_pattern2.42731756
17MP0003879_abnormal_hair_cell2.32842830
18MP0002736_abnormal_nociception_after2.30837430
19MP0002735_abnormal_chemical_nociception2.17180541
20MP0004885_abnormal_endolymph2.14551564
21MP0005646_abnormal_pituitary_gland2.06410630
22MP0003329_amyloid_beta_deposits1.94601609
23MP0004147_increased_porphyrin_level1.88875019
24MP0001970_abnormal_pain_threshold1.87165986
25MP0001440_abnormal_grooming_behavior1.85946452
26MP0002733_abnormal_thermal_nociception1.84906764
27MP0002067_abnormal_sensory_capabilities1.79487847
28MP0001502_abnormal_circadian_rhythm1.76561580
29MP0000920_abnormal_myelination1.71716242
30MP0003787_abnormal_imprinting1.70758108
31MP0003123_paternal_imprinting1.67568153
32MP0003690_abnormal_glial_cell1.57385194
33MP0002557_abnormal_social/conspecific_i1.55802048
34MP0003633_abnormal_nervous_system1.55444702
35MP0002066_abnormal_motor_capabilities/c1.55040986
36MP0004811_abnormal_neuron_physiology1.52212823
37MP0009780_abnormal_chondrocyte_physiolo1.50394792
38MP0004742_abnormal_vestibular_system1.47793154
39MP0001177_atelectasis1.42751936
40MP0006276_abnormal_autonomic_nervous1.39512105
41MP0003631_nervous_system_phenotype1.36695641
42MP0002184_abnormal_innervation1.36519151
43MP0005386_behavior/neurological_phenoty1.31266722
44MP0004924_abnormal_behavior1.31266722
45MP0001348_abnormal_lacrimal_gland1.31055481
46MP0002882_abnormal_neuron_morphology1.27256444
47MP0005167_abnormal_blood-brain_barrier1.23764783
48MP0000778_abnormal_nervous_system1.22074306
49MP0000955_abnormal_spinal_cord1.20662554
50MP0003122_maternal_imprinting1.18974965
51MP0001963_abnormal_hearing_physiology1.14157978
52MP0003634_abnormal_glial_cell1.11562794
53MP0003632_abnormal_nervous_system1.07711951
54MP0002229_neurodegeneration1.07221158
55MP0003705_abnormal_hypodermis_morpholog0.99491647
56MP0002152_abnormal_brain_morphology0.98463765
57MP0002249_abnormal_larynx_morphology0.94787646
58MP0005551_abnormal_eye_electrophysiolog0.91723763
59MP0008874_decreased_physiological_sensi0.89615052
60MP0005535_abnormal_body_temperature0.87297338
61MP0003283_abnormal_digestive_organ0.85417746
62MP0000566_synostosis0.84742852
63MP0008872_abnormal_physiological_respon0.83283425
64MP0001346_abnormal_lacrimal_gland0.81423871
65MP0001984_abnormal_olfaction0.79985352
66MP0002069_abnormal_eating/drinking_beha0.79657476
67MP0001188_hyperpigmentation0.78429488
68MP0003045_fibrosis0.77044169
69MP0000604_amyloidosis0.76807107
70MP0005670_abnormal_white_adipose0.76660438
71MP0001905_abnormal_dopamine_level0.71313873
72MP0004130_abnormal_muscle_cell0.71261855
73MP0004145_abnormal_muscle_electrophysio0.70054587
74MP0005623_abnormal_meninges_morphology0.69691588
75MP0001485_abnormal_pinna_reflex0.68099105
76MP0000579_abnormal_nail_morphology0.67847121
77MP0008877_abnormal_DNA_methylation0.61984642
78MP0002752_abnormal_somatic_nervous0.58068846
79MP0000747_muscle_weakness0.57285992
80MP0003075_altered_response_to0.56984861
81MP0003137_abnormal_impulse_conducting0.56677889
82MP0005645_abnormal_hypothalamus_physiol0.56232116
83MP0010769_abnormal_survival0.55539108
84MP0000026_abnormal_inner_ear0.54974157
85MP0004142_abnormal_muscle_tone0.53943375
86MP0010768_mortality/aging0.53228176
87MP0002638_abnormal_pupillary_reflex0.52944099
88MP0005409_darkened_coat_color0.52705939
89MP0001986_abnormal_taste_sensitivity0.52121893
90MP0000681_abnormal_thyroid_gland0.52084981
91MP0003956_abnormal_body_size0.50659337
92MP0002082_postnatal_lethality0.50376163
93MP0010770_preweaning_lethality0.50376163
94MP0000013_abnormal_adipose_tissue0.47724753
95MP0001731_abnormal_postnatal_growth0.47579008
96MP0001765_abnormal_ion_homeostasis0.45963417
97MP0001299_abnormal_eye_distance/0.44960973
98MP0002873_normal_phenotype0.44748032
99MP0000631_abnormal_neuroendocrine_gland0.44331991
100MP0000639_abnormal_adrenal_gland0.44067453

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.46424355
2Focal motor seizures (HP:0011153)6.87524015
3Action tremor (HP:0002345)6.43930763
4Febrile seizures (HP:0002373)5.69674730
5Focal seizures (HP:0007359)5.62232674
6Atonic seizures (HP:0010819)5.47956502
7Annular pancreas (HP:0001734)5.13058734
8Abnormality of binocular vision (HP:0011514)4.73239653
9Diplopia (HP:0000651)4.73239653
10Supranuclear gaze palsy (HP:0000605)4.66792414
11Epileptic encephalopathy (HP:0200134)4.60219396
12Ankle clonus (HP:0011448)4.56205419
13Progressive cerebellar ataxia (HP:0002073)4.53707840
14Cerebral hypomyelination (HP:0006808)4.48058708
15Visual hallucinations (HP:0002367)4.39693576
16Obstructive sleep apnea (HP:0002870)3.99058876
17Spastic gait (HP:0002064)3.97472974
18Neurofibrillary tangles (HP:0002185)3.87270950
19Generalized tonic-clonic seizures (HP:0002069)3.76063255
20Abnormal eating behavior (HP:0100738)3.74079543
21Abnormality of the lower motor neuron (HP:0002366)3.72608949
22Tetraplegia (HP:0002445)3.70198288
23Hemiplegia (HP:0002301)3.68418181
24Truncal ataxia (HP:0002078)3.62987813
25Dysmetria (HP:0001310)3.56232836
26Absence seizures (HP:0002121)3.52528199
27Limb dystonia (HP:0002451)3.43415231
28Intention tremor (HP:0002080)3.42548958
29Postural instability (HP:0002172)3.26309650
30Dialeptic seizures (HP:0011146)3.25289712
31Torticollis (HP:0000473)3.23807926
32Mutism (HP:0002300)3.18859334
33Urinary bladder sphincter dysfunction (HP:0002839)3.18038929
34Depression (HP:0000716)3.13335192
35Impaired smooth pursuit (HP:0007772)3.13045187
36Cerebral inclusion bodies (HP:0100314)3.08334521
37Abnormality of ocular smooth pursuit (HP:0000617)3.04190235
38Anxiety (HP:0000739)2.92781563
39Clonus (HP:0002169)2.92684689
40Status epilepticus (HP:0002133)2.85241196
41Abnormality of the corticospinal tract (HP:0002492)2.84201018
42Delusions (HP:0000746)2.83958341
43Sleep apnea (HP:0010535)2.80275046
44Spinal canal stenosis (HP:0003416)2.76839678
45Hemiparesis (HP:0001269)2.72525428
46Focal dystonia (HP:0004373)2.71728231
47Papilledema (HP:0001085)2.70629017
48Poor eye contact (HP:0000817)2.69524775
49Stereotypic behavior (HP:0000733)2.67257531
50Insomnia (HP:0100785)2.65940910
51Impaired vibration sensation in the lower limbs (HP:0002166)2.64868617
52Akinesia (HP:0002304)2.63946538
53Scanning speech (HP:0002168)2.63237535
54Choreoathetosis (HP:0001266)2.62571873
55Bradykinesia (HP:0002067)2.56729757
56Craniofacial dystonia (HP:0012179)2.52752591
57Lower limb asymmetry (HP:0100559)2.52510135
58Dysdiadochokinesis (HP:0002075)2.48689232
59CNS hypomyelination (HP:0003429)2.47742992
60Rapidly progressive (HP:0003678)2.45310258
61Lower limb muscle weakness (HP:0007340)2.38926606
62Neuronal loss in central nervous system (HP:0002529)2.35866538
63Rigidity (HP:0002063)2.35367566
64Ventricular fibrillation (HP:0001663)2.34249230
65Gaze-evoked nystagmus (HP:0000640)2.33306125
66Apathy (HP:0000741)2.30486415
67Abnormal social behavior (HP:0012433)2.30440468
68Impaired social interactions (HP:0000735)2.30440468
69Morphological abnormality of the pyramidal tract (HP:0002062)2.15467260
70Spastic tetraparesis (HP:0001285)2.14988168
71Impaired vibratory sensation (HP:0002495)2.12976388
72Genetic anticipation (HP:0003743)2.12142785
73Epileptiform EEG discharges (HP:0011182)2.11306338
74Aplasia involving bones of the upper limbs (HP:0009823)2.09917293
75Aplasia of the phalanges of the hand (HP:0009802)2.09917293
76Aplasia involving bones of the extremities (HP:0009825)2.09917293
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09867441
78Abnormality of alanine metabolism (HP:0010916)2.09867441
79Hyperalaninemia (HP:0003348)2.09867441
80Unsteady gait (HP:0002317)2.09831345
81Dysmetric saccades (HP:0000641)2.09804772
82Abnormality of saccadic eye movements (HP:0000570)2.09238863
83Urinary urgency (HP:0000012)2.06664750
84Postural tremor (HP:0002174)2.06080195
85Megalencephaly (HP:0001355)2.02722311
86Peripheral hypomyelination (HP:0007182)2.00803243
87Diminished motivation (HP:0000745)2.00219551
88Bundle branch block (HP:0011710)1.98436578
89Heart block (HP:0012722)1.95517010
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95374717
91Limb ataxia (HP:0002070)1.95127471
92Ocular albinism (HP:0001107)1.95068972
93Incomplete penetrance (HP:0003829)1.94723574
94Pointed chin (HP:0000307)1.94346074
95Gait ataxia (HP:0002066)1.90834653
96Iris hypopigmentation (HP:0007730)1.90373471
97EEG with generalized epileptiform discharges (HP:0011198)1.86628260
98Slow progression (HP:0003677)1.84042498
99Broad-based gait (HP:0002136)1.84015201
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.83451969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.26674023
2DAPK24.16503877
3RIPK14.07841333
4PAK63.87909040
5NTRK23.47903346
6EPHA43.26585715
7UHMK13.19645896
8MARK13.10342857
9MAP3K92.75134693
10CAMKK12.58853433
11PRPF4B2.30643540
12MINK12.29352809
13SGK4942.09357564
14SGK2232.09357564
15CAMKK22.04583708
16PRKD31.77842524
17GRK51.61367464
18SGK21.59898242
19WNK11.57627908
20PRKCH1.51786529
21CDK51.47237931
22CAMK2B1.46412977
23DAPK11.43597904
24PHKG11.43361264
25PHKG21.43361264
26CAMK11.41922670
27ARAF1.41442195
28PLK21.39624079
29SGK31.35529777
30LATS21.35043993
31TYRO31.31284812
32NTRK11.29868911
33KSR21.29388777
34SIK21.21840939
35LMTK21.17043253
36CDK151.14453362
37NEK61.13807611
38CDK191.13070509
39CDK181.09537452
40DYRK1A1.07637003
41STK381.05229158
42CDK11A1.04228812
43CAMK2G1.03846346
44FGFR21.02792129
45PRKCG1.00848236
46SGK10.97223584
47CDK140.93814716
48MAPK130.91448060
49STK110.90174603
50BRSK10.89235407
51MARK20.87129592
52CASK0.86456074
53ALK0.83485217
54MAPK120.82292375
55CAMK2A0.80945692
56MAP3K110.80738514
57PKN10.79526082
58DAPK30.79425030
59PINK10.76121513
60MAP3K130.73364896
61CAMK2D0.71455660
62PDK10.67698754
63PDPK10.67665816
64TRIB30.67059872
65CAMK40.64404560
66MAPK100.64260069
67SMG10.63931184
68MAPKAPK50.56022220
69RPS6KA30.55845092
70EEF2K0.53420374
71RPS6KB10.50493713
72BRAF0.49620128
73OXSR10.49469276
74IRAK20.47137057
75ROCK20.46240658
76PAK30.43941584
77PRKG20.39183379
78DYRK1B0.37697370
79TNK20.37506440
80FYN0.35709790
81HIPK20.34529222
82RAF10.33425985
83PRKCA0.31053188
84MAP3K20.30921147
85MAPK80.30868824
86MAP2K30.29864934
87MAP3K10.29609118
88ERBB20.29378457
89TAOK20.28081226
90CSNK1A10.27887048
91MAP2K10.27319758
92MAP3K30.26847977
93SRC0.26560619
94LIMK10.25727803
95ROCK10.24555207
96KSR10.23993584
97PRKCZ0.23206996
98FES0.23042384
99MAP2K40.22447433
100RIPK40.22186421

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.70054386
2Synaptic vesicle cycle_Homo sapiens_hsa047214.57358052
3GABAergic synapse_Homo sapiens_hsa047273.17757124
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.07769966
5Glutamatergic synapse_Homo sapiens_hsa047243.00924597
6Long-term potentiation_Homo sapiens_hsa047202.96136876
7Morphine addiction_Homo sapiens_hsa050322.84786578
8Circadian entrainment_Homo sapiens_hsa047132.79055445
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77048532
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.66580685
11Amphetamine addiction_Homo sapiens_hsa050312.53705354
12Insulin secretion_Homo sapiens_hsa049112.15804818
13Dopaminergic synapse_Homo sapiens_hsa047282.05891206
14Gastric acid secretion_Homo sapiens_hsa049711.91854696
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80046446
16Cocaine addiction_Homo sapiens_hsa050301.78026396
17Cholinergic synapse_Homo sapiens_hsa047251.74541851
18Salivary secretion_Homo sapiens_hsa049701.62977938
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62680536
20Collecting duct acid secretion_Homo sapiens_hsa049661.59820848
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57025683
22Taste transduction_Homo sapiens_hsa047421.55425522
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45990603
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.45170815
25Calcium signaling pathway_Homo sapiens_hsa040201.40359984
26cAMP signaling pathway_Homo sapiens_hsa040241.40080818
27Oxytocin signaling pathway_Homo sapiens_hsa049211.36448165
28Vitamin B6 metabolism_Homo sapiens_hsa007501.36216783
29Long-term depression_Homo sapiens_hsa047301.31249768
30Serotonergic synapse_Homo sapiens_hsa047261.28388524
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25110179
32Arginine biosynthesis_Homo sapiens_hsa002201.24718402
33GnRH signaling pathway_Homo sapiens_hsa049121.23231566
34Renin secretion_Homo sapiens_hsa049241.22995437
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16729971
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12321212
37Vibrio cholerae infection_Homo sapiens_hsa051101.09569192
38Olfactory transduction_Homo sapiens_hsa047401.03514682
39Estrogen signaling pathway_Homo sapiens_hsa049151.03200623
40Bile secretion_Homo sapiens_hsa049761.02160673
41Pancreatic secretion_Homo sapiens_hsa049720.93477183
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.91583659
43Arginine and proline metabolism_Homo sapiens_hsa003300.89749196
44Glioma_Homo sapiens_hsa052140.89180129
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86561626
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86408622
47Gap junction_Homo sapiens_hsa045400.85673360
48Thyroid hormone synthesis_Homo sapiens_hsa049180.85353603
49Prion diseases_Homo sapiens_hsa050200.83554022
50Type II diabetes mellitus_Homo sapiens_hsa049300.82360906
51Melanogenesis_Homo sapiens_hsa049160.81694086
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79882315
53Oocyte meiosis_Homo sapiens_hsa041140.79173061
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76541472
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69296906
56ErbB signaling pathway_Homo sapiens_hsa040120.68342478
57Inositol phosphate metabolism_Homo sapiens_hsa005620.67513268
58Cardiac muscle contraction_Homo sapiens_hsa042600.67401390
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65886930
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60670689
61Alcoholism_Homo sapiens_hsa050340.60184054
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58464985
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57679636
64MAPK signaling pathway_Homo sapiens_hsa040100.56844957
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.56072973
66Ras signaling pathway_Homo sapiens_hsa040140.55942542
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53634154
68VEGF signaling pathway_Homo sapiens_hsa043700.53079369
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.52983332
70Glucagon signaling pathway_Homo sapiens_hsa049220.52062147
71Choline metabolism in cancer_Homo sapiens_hsa052310.50277952
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49063420
73Endocytosis_Homo sapiens_hsa041440.48821234
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47383833
75Mineral absorption_Homo sapiens_hsa049780.47295431
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.46123115
77Circadian rhythm_Homo sapiens_hsa047100.45813237
78Axon guidance_Homo sapiens_hsa043600.45111886
79Rap1 signaling pathway_Homo sapiens_hsa040150.43290282
80Biosynthesis of amino acids_Homo sapiens_hsa012300.40601747
81Fatty acid biosynthesis_Homo sapiens_hsa000610.40507325
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40049026
83AMPK signaling pathway_Homo sapiens_hsa041520.38949543
84Phototransduction_Homo sapiens_hsa047440.37258488
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.37148869
86Nitrogen metabolism_Homo sapiens_hsa009100.33364139
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26158461
88Regulation of autophagy_Homo sapiens_hsa041400.24126431
89mTOR signaling pathway_Homo sapiens_hsa041500.23566503
90Alzheimers disease_Homo sapiens_hsa050100.23071100
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23048624
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.21093293
93Dorso-ventral axis formation_Homo sapiens_hsa043200.20124405
94HIF-1 signaling pathway_Homo sapiens_hsa040660.19831545
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18330738
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17469216
97Insulin signaling pathway_Homo sapiens_hsa049100.15369750
98Histidine metabolism_Homo sapiens_hsa003400.15049180
99Wnt signaling pathway_Homo sapiens_hsa043100.12947398
100Folate biosynthesis_Homo sapiens_hsa007900.12538028

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