PRR29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.12682443
2regulation of cilium movement (GO:0003352)7.81596062
3primary alcohol catabolic process (GO:0034310)6.05786233
4regulation of memory T cell differentiation (GO:0043380)5.94097353
5vitamin transmembrane transport (GO:0035461)5.86318376
6ventricular system development (GO:0021591)5.73155258
7microtubule bundle formation (GO:0001578)5.58921593
8response to xenobiotic stimulus (GO:0009410)5.51443479
9intraciliary transport (GO:0042073)5.41163025
10regulation of activation of Janus kinase activity (GO:0010533)5.40362754
11cilium organization (GO:0044782)5.38555280
12regulation of germinal center formation (GO:0002634)5.31868386
13positive regulation of tolerance induction (GO:0002645)5.28745781
14tolerance induction (GO:0002507)5.25263259
15ethanol metabolic process (GO:0006067)5.22548970
16cilium assembly (GO:0042384)5.20933605
17positive regulation of prostaglandin secretion (GO:0032308)5.11654805
18positive regulation of heat generation (GO:0031652)5.06349085
19diterpenoid biosynthetic process (GO:0016102)4.97720199
20regulation of fever generation (GO:0031620)4.91443458
21regulation of p38MAPK cascade (GO:1900744)4.84700201
22positive regulation of p38MAPK cascade (GO:1900745)4.79578050
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.72275199
24negative regulation of T cell differentiation in thymus (GO:0033085)4.69377743
25negative regulation of B cell mediated immunity (GO:0002713)4.66515645
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.66515645
27regulation of microtubule-based movement (GO:0060632)4.55194308
28protein localization to cilium (GO:0061512)4.45140588
29negative regulation of inclusion body assembly (GO:0090084)4.44660034
30centriole assembly (GO:0098534)4.43212853
31regulation of prostaglandin secretion (GO:0032306)4.41033328
32regulation of gamma-delta T cell differentiation (GO:0045586)4.39156839
33negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.34038272
34CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.33641646
35T-helper cell differentiation (GO:0042093)4.33641646
36negative regulation of cAMP-mediated signaling (GO:0043951)4.31625387
37regulation of interleukin-13 production (GO:0032656)4.22548099
38negative regulation of interleukin-10 production (GO:0032693)4.17443294
39lung epithelium development (GO:0060428)4.16933622
40regulation of interleukin-5 production (GO:0032674)4.16749897
41regulation of tolerance induction (GO:0002643)4.11788319
42negative regulation of humoral immune response (GO:0002921)4.06362619
43negative regulation of bone resorption (GO:0045779)4.03709980
44cellular component assembly involved in morphogenesis (GO:0010927)4.03494533
45regulation of heat generation (GO:0031650)3.93506692
46cilium morphogenesis (GO:0060271)3.90517822
47positive regulation of osteoclast differentiation (GO:0045672)3.88630511
48microtubule-based movement (GO:0007018)3.88226497
49cell projection assembly (GO:0030031)3.87607069
50ethanol oxidation (GO:0006069)3.82329230
51regulation of gamma-delta T cell activation (GO:0046643)3.79031474
52positive regulation of T-helper 1 type immune response (GO:0002827)3.76935836
53nucleoside diphosphate phosphorylation (GO:0006165)3.76316035
54positive regulation of icosanoid secretion (GO:0032305)3.74601198
55positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.74281436
56entrainment of circadian clock by photoperiod (GO:0043153)3.74132800
57sperm capacitation (GO:0048240)3.73535787
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.73265500
59surfactant homeostasis (GO:0043129)3.70890645
60endothelial cell chemotaxis (GO:0035767)3.69931302
61pericardium development (GO:0060039)3.69883886
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.69701459
63positive regulation of defense response to virus by host (GO:0002230)3.67012257
64T cell differentiation involved in immune response (GO:0002292)3.64526651
65alpha-beta T cell differentiation involved in immune response (GO:0002293)3.64526651
66alpha-beta T cell activation involved in immune response (GO:0002287)3.64526651
67response to interleukin-15 (GO:0070672)3.64349270
68sarcomere organization (GO:0045214)3.64078007
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64058319
70negative regulation of cell killing (GO:0031342)3.64058319
71glomerular epithelial cell development (GO:0072310)3.60157266
72interferon-gamma production (GO:0032609)3.57151642
73regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.55446944
74retinoic acid metabolic process (GO:0042573)3.50279967
75terpenoid biosynthetic process (GO:0016114)3.47713824
76exogenous drug catabolic process (GO:0042738)3.47090896
77hydrogen peroxide biosynthetic process (GO:0050665)3.44171250
78axoneme assembly (GO:0035082)3.38431674
79endoderm formation (GO:0001706)3.38223755
80positive regulation of cell fate commitment (GO:0010455)3.37303121
81positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36547934
82lymph node development (GO:0048535)3.36147004
83Peyers patch development (GO:0048541)3.36038173
84mucosal-associated lymphoid tissue development (GO:0048537)3.36038173
85G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.35701364
86cellular response to interleukin-15 (GO:0071350)3.35056177
87positive regulation of T-helper cell differentiation (GO:0045624)3.34662640
88axonemal dynein complex assembly (GO:0070286)3.34482519
89regulation of T cell mediated cytotoxicity (GO:0001914)3.32648822
90establishment of apical/basal cell polarity (GO:0035089)3.30147767
91cellular response to nicotine (GO:0071316)3.28665120
92nitric oxide biosynthetic process (GO:0006809)3.28515857
93positive regulation of bone resorption (GO:0045780)3.27117278
94positive regulation of bone remodeling (GO:0046852)3.27117278
95cilium movement (GO:0003341)3.25369806
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.23796400
97cellular zinc ion homeostasis (GO:0006882)3.23066134
98cytoplasmic microtubule organization (GO:0031122)3.20420623
99positive thymic T cell selection (GO:0045059)3.18785721
100microtubule depolymerization (GO:0007019)3.16279898
101muscle filament sliding (GO:0030049)3.12327558
102actin-myosin filament sliding (GO:0033275)3.12327558
103negative regulation of bone remodeling (GO:0046851)3.08203799
104positive regulation of interleukin-17 production (GO:0032740)3.07851810
105reactive oxygen species biosynthetic process (GO:1903409)3.06086902
106NIK/NF-kappaB signaling (GO:0038061)3.04825487
107sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03336869
108regulation of skeletal muscle contraction (GO:0014819)3.03057780
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98928280
110positive regulation of histone deacetylation (GO:0031065)2.98528893
111glutathione derivative biosynthetic process (GO:1901687)2.93538742
112glutathione derivative metabolic process (GO:1901685)2.93538742
113positive regulation of circadian rhythm (GO:0042753)2.92792751
114negative regulation of neurotransmitter secretion (GO:0046929)2.92632560
115positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90777320
116viral protein processing (GO:0019082)2.90711100
117creatine metabolic process (GO:0006600)2.89622449
118lipid storage (GO:0019915)2.88858052
119positive regulation of fatty acid transport (GO:2000193)2.88641237
120oxygen transport (GO:0015671)2.88067146
121regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86793559
122CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.86301055
123mammary gland alveolus development (GO:0060749)2.86253812
124sperm motility (GO:0030317)2.85867355
125photoperiodism (GO:0009648)2.85772503
126chemical homeostasis within a tissue (GO:0048875)2.85639864
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85639289
128regulation of fatty acid transport (GO:2000191)2.84555615
129negative regulation of adaptive immune response (GO:0002820)2.83341517
130very-low-density lipoprotein particle assembly (GO:0034379)2.81891736
131establishment of monopolar cell polarity (GO:0061162)2.81359707
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.81359707
133regulation of cholesterol homeostasis (GO:2000188)2.81187890
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81186669
135lateral ventricle development (GO:0021670)2.81124194
136entrainment of circadian clock (GO:0009649)2.80504526
137positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80485799
138regulation of T-helper 1 type immune response (GO:0002825)2.80280679
139regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.79950271
140negative regulation of thymocyte apoptotic process (GO:0070244)2.79166029
141one-carbon compound transport (GO:0019755)2.78355998
142response to corticosterone (GO:0051412)2.75784047
143microtubule polymerization or depolymerization (GO:0031109)2.74201957
144circadian regulation of gene expression (GO:0032922)2.73604344
145regulation of transcription involved in cell fate commitment (GO:0060850)2.73433746
146actin-mediated cell contraction (GO:0070252)2.71746434
147positive regulation of receptor recycling (GO:0001921)2.70685361
148retinol metabolic process (GO:0042572)2.70131863
149regulation of icosanoid secretion (GO:0032303)2.70123783
150mammary gland epithelial cell proliferation (GO:0033598)2.69257146
151primary alcohol metabolic process (GO:0034308)2.68898307
152left/right axis specification (GO:0070986)2.67818184
153lipoxygenase pathway (GO:0019372)2.66048184
154alpha-beta T cell differentiation (GO:0046632)2.65349755
155drug catabolic process (GO:0042737)2.64871366
156negative regulation of fatty acid transport (GO:2000192)2.64504391
157regulation of interleukin-6 biosynthetic process (GO:0045408)2.61796944
158O-glycan processing (GO:0016266)2.61015279
159phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.60127035
160superoxide anion generation (GO:0042554)2.57005743
161hydrogen peroxide catabolic process (GO:0042744)2.51639227
162determination of left/right symmetry (GO:0007368)2.50281065
163negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.48067354
164regulation of interleukin-4 production (GO:0032673)2.47746906
165aldehyde catabolic process (GO:0046185)2.45368296
166phosphatidylcholine biosynthetic process (GO:0006656)2.43471778
167determination of bilateral symmetry (GO:0009855)2.36799568
168L-ascorbic acid metabolic process (GO:0019852)2.36508434
169smoothened signaling pathway (GO:0007224)2.35802811
170sialylation (GO:0097503)2.35349165
171establishment of tissue polarity (GO:0007164)2.34977977
172establishment of planar polarity (GO:0001736)2.34977977
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.34952428
174regulation of autophagic vacuole assembly (GO:2000785)2.33016158
175hypotonic response (GO:0006971)2.32117520
176specification of symmetry (GO:0009799)2.30749358
177negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.29955150
178carnitine metabolic process (GO:0009437)2.28909507
179glutathione metabolic process (GO:0006749)2.28050858
180multicellular organismal water homeostasis (GO:0050891)2.27971486
181protein refolding (GO:0042026)2.27942728
182gas transport (GO:0015669)2.27682954
183hydrogen peroxide metabolic process (GO:0042743)2.27415184
184centriole replication (GO:0007099)2.26389065
185calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.21884329
186embryonic heart tube development (GO:0035050)2.21123841
187regulation of vacuole organization (GO:0044088)2.17448272
188organelle assembly (GO:0070925)2.16676228
189cilium or flagellum-dependent cell motility (GO:0001539)16.6806825
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.8911051
191motile cilium assembly (GO:0044458)13.5072199
192epithelial cilium movement (GO:0003351)12.6457377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.83210184
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.55138654
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14825011
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.09666941
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.89516685
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88253739
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76877969
8CLOCK_20551151_ChIP-Seq_293T_Human2.71237465
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37727485
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.21176664
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17195305
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.16453601
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11940101
14GATA1_22025678_ChIP-Seq_K562_Human2.08074321
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.05456451
16RUNX_20019798_ChIP-Seq_JUKART_Human1.95609699
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93896908
18STAT1_20625510_ChIP-Seq_HELA_Human1.93554222
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92145400
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88085535
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84976844
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.84206204
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.83562988
24VDR_22108803_ChIP-Seq_LS180_Human1.83094340
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.81514237
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.81514237
27MAF_26560356_Chip-Seq_TH1_Human1.81068443
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77029428
29MYB_26560356_Chip-Seq_TH2_Human1.75819516
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71892043
31TCF7_22412390_ChIP-Seq_EML_Mouse1.70514057
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.69486670
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.68422680
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67089016
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66245783
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61926029
37SCL_19346495_ChIP-Seq_HPC-7_Human1.61834318
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61682126
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61506183
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.59121053
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58489633
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58185789
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.57951014
44VDR_24787735_ChIP-Seq_THP-1_Human1.54439497
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53397161
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47761605
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.47094972
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46727191
49GATA1_19941826_ChIP-Seq_K562_Human1.44616496
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44121311
51MYB_26560356_Chip-Seq_TH1_Human1.44061947
52MYC_22102868_ChIP-Seq_BL_Human1.43361627
53SMC4_20622854_ChIP-Seq_HELA_Human1.42991033
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42126774
55KDM2B_26808549_Chip-Seq_DND41_Human1.41484503
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.39471698
57RAD21_21589869_ChIP-Seq_MESCs_Mouse1.38993541
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36197767
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35947769
60P300_27268052_Chip-Seq_Bcells_Human1.34108810
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.31930552
62TP63_22573176_ChIP-Seq_HFKS_Human1.31494317
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29279357
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29137227
65TP63_23658742_ChIP-Seq_EP156T_Human1.28735246
66CTCF_20526341_ChIP-Seq_ESCs_Human1.28201942
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.28142032
68DROSHA_22980978_ChIP-Seq_HELA_Human1.27964361
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.27911952
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.27801975
71P68_20966046_ChIP-Seq_HELA_Human1.25831942
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24973190
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24316128
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23846791
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23250016
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22611434
77BCL6_27268052_Chip-Seq_Bcells_Human1.22253722
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21803647
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21773270
80PHF8_20622854_ChIP-Seq_HELA_Human1.21616836
81GATA3_27048872_Chip-Seq_THYMUS_Human1.21581028
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20257083
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19773791
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19061838
85BCAT_22108803_ChIP-Seq_LS180_Human1.18839126
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.18133529
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14699029
88GATA2_19941826_ChIP-Seq_K562_Human1.14543407
89CEBPB_22108803_ChIP-Seq_LS180_Human1.14283091
90SPI1_23127762_ChIP-Seq_K562_Human1.14172742
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13707723
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13701546
93E2F1_20622854_ChIP-Seq_HELA_Human1.12732277
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.12623908
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12171624
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12049394
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11745124
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11258371
99BCOR_27268052_Chip-Seq_Bcells_Human1.10712865
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10287923
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10242434
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10207292
103ETV1_20927104_ChIP-Seq_GIST48_Human1.09647424
104KDM2B_26808549_Chip-Seq_K562_Human1.09470758
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09230063
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08729077
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08607256
108UTX_26944678_Chip-Seq_JUKART_Human1.08053157
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07598035
110SOX2_20726797_ChIP-Seq_SW620_Human1.06766614
111GATA3_26560356_Chip-Seq_TH2_Human1.06599061
112VDR_24763502_ChIP-Seq_THP-1_Human1.06572071
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06225970
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05758267
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05098729
116GATA4_25053715_ChIP-Seq_YYC3_Human1.04929989
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04834191
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04690077
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04312678
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03886121
121PHF8_20622853_ChIP-Seq_HELA_Human1.03110805
122HNFA_21074721_ChIP-Seq_CACO-2_Human1.02996920
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02771455
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.02599457
125SOX2_21211035_ChIP-Seq_LN229_Human1.02542652
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02261771
127FOXA1_25552417_ChIP-Seq_VCAP_Human1.01594022
128KDM2B_26808549_Chip-Seq_JURKAT_Human1.01042790
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00144079
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.98741421
131KLF5_25053715_ChIP-Seq_YYC3_Human0.98456930
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.98265041
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96867027
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.96042757
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.95759007
136FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95759007
137RBPJ_21746931_ChIP-Seq_IB4_Human0.95599949
138AR_20517297_ChIP-Seq_VCAP_Human0.95549143
139RACK7_27058665_Chip-Seq_MCF-7_Human0.95541462
140SPI1_20517297_ChIP-Seq_HL60_Human0.95026484
141CTCF_27219007_Chip-Seq_Bcells_Human0.94470294
142CJUN_26792858_Chip-Seq_BT549_Human0.94351380
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.94294181
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94073872
145GATA6_21074721_ChIP-Seq_CACO-2_Human0.94010297
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93503445
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92821863
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92563778
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92505323
150PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92433669
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92431212
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92382643
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91493792
154TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91143523
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.91137205
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90868429
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.87661707
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86037536
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85450852
160AHR_22903824_ChIP-Seq_MCF-7_Human0.85240579
161LXR_22292898_ChIP-Seq_THP-1_Human0.85157106
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.85023718
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84488692
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83451172
165SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83208750
166ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82923560
167SMRT_27268052_Chip-Seq_Bcells_Human0.81602642
168TCF4_18268006_ChIP-ChIP_LS174T_Human0.81262825
169WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81094984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.81612809
2MP0002653_abnormal_ependyma_morphology5.53847591
3MP0002132_abnormal_respiratory_system5.14106625
4MP0002837_dystrophic_cardiac_calcinosis3.66349651
5MP0002877_abnormal_melanocyte_morpholog3.65478970
6MP0002138_abnormal_hepatobiliary_system3.42954035
7MP0000013_abnormal_adipose_tissue3.29928662
8MP0004510_myositis3.28780767
9MP0000685_abnormal_immune_system2.93077455
10MP0002909_abnormal_adrenal_gland2.63084613
11MP0001790_abnormal_immune_system2.61747639
12MP0005387_immune_system_phenotype2.61747639
13MP0001984_abnormal_olfaction2.59085435
14MP0004133_heterotaxia2.57098769
15MP0005464_abnormal_platelet_physiology2.39468930
16MP0003724_increased_susceptibility_to2.32237867
17MP0003763_abnormal_thymus_physiology2.22575107
18MP0000749_muscle_degeneration2.22276493
19MP0002405_respiratory_system_inflammati2.17058373
20MP0003646_muscle_fatigue2.15313704
21MP0002277_abnormal_respiratory_mucosa2.10205035
22MP0005623_abnormal_meninges_morphology2.09935908
23MP0004036_abnormal_muscle_relaxation1.99847570
24MP0004084_abnormal_cardiac_muscle1.99824428
25MP0005330_cardiomyopathy1.95768015
26MP0004264_abnormal_extraembryonic_tissu1.94797483
27MP0000003_abnormal_adipose_tissue1.93114090
28MP0000751_myopathy1.92862963
29MP0001502_abnormal_circadian_rhythm1.90844158
30MP0008961_abnormal_basal_metabolism1.85620635
31MP0008789_abnormal_olfactory_epithelium1.84615311
32MP0003878_abnormal_ear_physiology1.81296906
33MP0005377_hearing/vestibular/ear_phenot1.81296906
34MP0001765_abnormal_ion_homeostasis1.78565534
35MP0005083_abnormal_biliary_tract1.77650684
36MP0010155_abnormal_intestine_physiology1.75104049
37MP0004782_abnormal_surfactant_physiolog1.72818838
38MP0004043_abnormal_pH_regulation1.72154035
39MP0001879_abnormal_lymphatic_vessel1.70434783
40MP0005671_abnormal_response_to1.67417328
41MP0003656_abnormal_erythrocyte_physiolo1.66754791
42MP0003300_gastrointestinal_ulcer1.66432061
43MP0002168_other_aberrant_phenotype1.64260816
44MP0010368_abnormal_lymphatic_system1.61590533
45MP0003436_decreased_susceptibility_to1.60866690
46MP0002693_abnormal_pancreas_physiology1.60743987
47MP0000383_abnormal_hair_follicle1.60249068
48MP0009780_abnormal_chondrocyte_physiolo1.57801477
49MP0004087_abnormal_muscle_fiber1.56676984
50MP0001873_stomach_inflammation1.55389870
51MP0001800_abnormal_humoral_immune1.54855053
52MP0002106_abnormal_muscle_physiology1.53896006
53MP0004019_abnormal_vitamin_homeostasis1.52961040
54MP0005000_abnormal_immune_tolerance1.52731249
55MP0004215_abnormal_myocardial_fiber1.47842835
56MP0003828_pulmonary_edema1.46977424
57MP0004145_abnormal_muscle_electrophysio1.46585419
58MP0001881_abnormal_mammary_gland1.44164268
59MP0002933_joint_inflammation1.36983089
60MP0005620_abnormal_muscle_contractility1.36463786
61MP0000759_abnormal_skeletal_muscle1.35688718
62MP0002928_abnormal_bile_duct1.34805431
63MP0002148_abnormal_hypersensitivity_rea1.34673626
64MP0002723_abnormal_immune_serum1.34654655
65MP0002972_abnormal_cardiac_muscle1.32375978
66MP0003866_abnormal_defecation1.31868964
67MP0000343_altered_response_to1.31531833
68MP0002876_abnormal_thyroid_physiology1.31471279
69MP0000703_abnormal_thymus_morphology1.30985299
70MP0005084_abnormal_gallbladder_morpholo1.30926093
71MP0001851_eye_inflammation1.29593608
72MP0009785_altered_susceptibility_to1.27589317
73MP0005076_abnormal_cell_differentiation1.27254699
74MP0002282_abnormal_trachea_morphology1.26111940
75MP0005165_increased_susceptibility_to1.26011785
76MP0003137_abnormal_impulse_conducting1.21065370
77MP0001501_abnormal_sleep_pattern1.20738943
78MP0004484_altered_response_of1.19425628
79MP0005369_muscle_phenotype1.17871557
80MP0008004_abnormal_stomach_pH1.17433902
81MP0002078_abnormal_glucose_homeostasis1.16256784
82MP0000249_abnormal_blood_vessel1.15815071
83MP0001944_abnormal_pancreas_morphology1.15628145
84MP0008995_early_reproductive_senescence1.15535662
85MP0003303_peritoneal_inflammation1.15244843
86MP0004130_abnormal_muscle_cell1.13666764
87MP0002160_abnormal_reproductive_system1.13105719
88MP0004947_skin_inflammation1.12646639
89MP0001958_emphysema1.11906129
90MP0003183_abnormal_peptide_metabolism1.11655780
91MP0010678_abnormal_skin_adnexa1.11191712
92MP0005375_adipose_tissue_phenotype1.10271673
93MP0000750_abnormal_muscle_regeneration1.09933878
94MP0002420_abnormal_adaptive_immunity1.09868730
95MP0000733_abnormal_muscle_development1.09496469
96MP0001845_abnormal_inflammatory_respons1.09258372
97MP0000747_muscle_weakness1.08251021
98MP0003959_abnormal_lean_body1.08095404
99MP0006082_CNS_inflammation1.07410867
100MP0001819_abnormal_immune_cell1.06735437
101MP0005636_abnormal_mineral_homeostasis1.06461823
102MP0001835_abnormal_antigen_presentation1.06320734
103MP0002452_abnormal_antigen_presenting1.05767484
104MP0002971_abnormal_brown_adipose1.05755357
105MP0003638_abnormal_response/metabolism_1.04222530
106MP0010630_abnormal_cardiac_muscle1.03447555
107MP0005167_abnormal_blood-brain_barrier1.03108917
108MP0001663_abnormal_digestive_system1.02296599
109MP0005395_other_phenotype1.01822800
110MP0000465_gastrointestinal_hemorrhage1.00205454
111MP0001544_abnormal_cardiovascular_syste0.99745771
112MP0005385_cardiovascular_system_phenoty0.99745771
113MP0002269_muscular_atrophy0.99728618
114MP0001533_abnormal_skeleton_physiology0.98858230
115MP0000716_abnormal_immune_system0.98312340
116MP0008872_abnormal_physiological_respon0.97120696
117MP0009763_increased_sensitivity_to0.96079344
118MP0002419_abnormal_innate_immunity0.95721925
119MP0002166_altered_tumor_susceptibility0.94175328
120MP0005409_darkened_coat_color0.92468030
121MP0005394_taste/olfaction_phenotype0.92125522
122MP0005499_abnormal_olfactory_system0.92125522
123MP0000609_abnormal_liver_physiology0.91485545
124MP0005085_abnormal_gallbladder_physiolo0.91067638
125MP0005164_abnormal_response_to0.90735065
126MP0008775_abnormal_heart_ventricle0.90406630
127MP0004883_abnormal_blood_vessel0.90199449
128MP0002136_abnormal_kidney_physiology0.89852660
129MP0002998_abnormal_bone_remodeling0.88361479
130MP0001849_ear_inflammation0.87871958
131MP0000678_abnormal_parathyroid_gland0.87806069
132MP0002722_abnormal_immune_system0.86972283
133MP0002254_reproductive_system_inflammat0.85957211
134MP0004085_abnormal_heartbeat0.84235745
135MP0009333_abnormal_splenocyte_physiolog0.84189564
136MP0000566_synostosis0.83898725
137MP0002398_abnormal_bone_marrow0.82915165
138MP0005645_abnormal_hypothalamus_physiol0.82778884
139MP0003045_fibrosis0.82396882
140MP0009765_abnormal_xenobiotic_induced0.80847502
141MP0000230_abnormal_systemic_arterial0.80535173
142MP0003075_altered_response_to0.79691252
143MP0000858_altered_metastatic_potential0.77994112
144MP0005310_abnormal_salivary_gland0.76679950
145MP0009643_abnormal_urine_homeostasis0.74598016
146MP0005025_abnormal_response_to0.74522513
147MP0002735_abnormal_chemical_nociception0.70211625
148MP0009764_decreased_sensitivity_to0.68725680
149MP0005365_abnormal_bile_salt0.67620594
150MP0002638_abnormal_pupillary_reflex0.67233007
151MP0005389_reproductive_system_phenotype0.65338852
152MP0000681_abnormal_thyroid_gland0.64547520
153MP0000689_abnormal_spleen_morphology0.64031631
154MP0001346_abnormal_lacrimal_gland0.61897544
155MP0006036_abnormal_mitochondrial_physio0.60105173
156MP0001664_abnormal_digestion0.59994634
157MP0005646_abnormal_pituitary_gland0.59688567
158MP0002429_abnormal_blood_cell0.59294438
159MP0004147_increased_porphyrin_level0.58881267
160MP0005166_decreased_susceptibility_to0.57856354

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)7.22206258
2Increased density of long bones (HP:0006392)6.71076071
3Persistence of primary teeth (HP:0006335)5.16322330
4Retrobulbar optic neuritis (HP:0100654)5.05333546
5Optic neuritis (HP:0100653)5.05333546
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.57896447
7Orchitis (HP:0100796)4.53390567
8Chronic bronchitis (HP:0004469)4.43978076
9Keratoconjunctivitis (HP:0001096)4.40427632
10Myositis (HP:0100614)4.23653230
11Keratoconjunctivitis sicca (HP:0001097)4.22804950
12Infertility (HP:0000789)4.21547537
13Abnormal respiratory motile cilium physiology (HP:0012261)4.16778694
14Exercise-induced myalgia (HP:0003738)4.16127478
15Abnormal ciliary motility (HP:0012262)3.89531956
16Male infertility (HP:0003251)3.86875565
17Recurrent otitis media (HP:0000403)3.83722140
18Calf muscle hypertrophy (HP:0008981)3.68271355
19Muscle hypertrophy of the lower extremities (HP:0008968)3.66753872
20Pancreatic fibrosis (HP:0100732)3.58453483
21Occipital encephalocele (HP:0002085)3.49414128
22True hermaphroditism (HP:0010459)3.44155486
23Bronchiectasis (HP:0002110)3.39561236
24Sudden death (HP:0001699)3.36598520
25Pulmonary infiltrates (HP:0002113)3.35007502
26Abnormality of the nasal mucosa (HP:0000433)3.33978239
27Chronic otitis media (HP:0000389)3.26868285
28Interstitial pulmonary disease (HP:0006530)3.26628599
29Exercise-induced muscle cramps (HP:0003710)3.26309817
30Ventricular tachycardia (HP:0004756)3.20224312
31Abnormality of the left ventricular outflow tract (HP:0011103)3.17855821
32Subaortic stenosis (HP:0001682)3.17855821
33Bronchitis (HP:0012387)3.15366257
34Hyperinsulinemic hypoglycemia (HP:0000825)3.13309302
35Premature loss of primary teeth (HP:0006323)3.11635790
36Nasal polyposis (HP:0100582)3.11380218
37Pancreatic cysts (HP:0001737)3.05563022
38Abnormal respiratory motile cilium morphology (HP:0005938)3.03291898
39Abnormal respiratory epithelium morphology (HP:0012253)3.03291898
40Distal arthrogryposis (HP:0005684)2.99470302
41Hypoglycemic coma (HP:0001325)2.98973479
42Atelectasis (HP:0100750)2.91354876
43Cystic liver disease (HP:0006706)2.88276487
44Myoglobinuria (HP:0002913)2.86386181
45Hyperkalemia (HP:0002153)2.85926361
46Molar tooth sign on MRI (HP:0002419)2.85904709
47Abnormality of midbrain morphology (HP:0002418)2.85904709
48Right ventricular cardiomyopathy (HP:0011663)2.82578152
49Nephronophthisis (HP:0000090)2.82007632
50Gout (HP:0001997)2.81892645
51Hyporeflexia of lower limbs (HP:0002600)2.79093227
52Muscle fiber splitting (HP:0003555)2.71726511
53Hyperactive renin-angiotensin system (HP:0000841)2.67587875
54Hypoglycemic seizures (HP:0002173)2.67550847
55IgM deficiency (HP:0002850)2.60291196
56Muscle fiber inclusion bodies (HP:0100299)2.52244409
57Abnormality of the calf musculature (HP:0001430)2.50281943
58Hemoptysis (HP:0002105)2.49898675
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43707527
60Thyroiditis (HP:0100646)2.42531533
61Chronic hepatic failure (HP:0100626)2.41341636
62EMG: myopathic abnormalities (HP:0003458)2.40945088
63Hypertensive crisis (HP:0100735)2.39482259
64T lymphocytopenia (HP:0005403)2.34763914
65Postaxial foot polydactyly (HP:0001830)2.34349371
66Symptomatic seizures (HP:0011145)2.31084281
67Lipoatrophy (HP:0100578)2.30267679
68Abnormality of T cell number (HP:0011839)2.29989212
69Hyperglycemia (HP:0003074)2.29679916
70Recurrent bronchitis (HP:0002837)2.29625044
71Spontaneous hematomas (HP:0007420)2.29108378
72Myotonia (HP:0002486)2.28979717
73Primary atrial arrhythmia (HP:0001692)2.28451755
74Abnormality of the renal medulla (HP:0100957)2.27422664
75Atrial fibrillation (HP:0005110)2.25472929
76Decreased circulating renin level (HP:0003351)2.21716111
77Mucosal telangiectasiae (HP:0100579)2.19846777
78Congenital hepatic fibrosis (HP:0002612)2.18207162
79Muscle stiffness (HP:0003552)2.17888830
80Congenital malformation of the right heart (HP:0011723)2.17243887
81Double outlet right ventricle (HP:0001719)2.17243887
82Supraventricular tachycardia (HP:0004755)2.16222001
83Atrioventricular block (HP:0001678)2.15780781
84Xerostomia (HP:0000217)2.15114980
85Neoplasm of head and neck (HP:0012288)2.14993404
86Esophageal neoplasm (HP:0100751)2.14993404
87Pancreatic islet-cell hyperplasia (HP:0004510)2.14428990
88Supraventricular arrhythmia (HP:0005115)2.12300888
89Severe combined immunodeficiency (HP:0004430)2.11481784
90Keratitis (HP:0000491)2.08485969
91Polycythemia (HP:0001901)2.05749420
92Hypokalemia (HP:0002900)2.05185319
93Round ear (HP:0100830)2.04891203
94Asplenia (HP:0001746)2.04505194
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.03150425
96Type 1 muscle fiber predominance (HP:0003803)2.02966118
97Dilated cardiomyopathy (HP:0001644)2.02088732
98Difficulty running (HP:0009046)2.01796816
99Nemaline bodies (HP:0003798)2.01757013
100Recurrent sinusitis (HP:0011108)2.01668965
101Rhabdomyolysis (HP:0003201)2.01048499
102Pulmonary embolism (HP:0002204)2.01031471
103Insulin-resistant diabetes mellitus (HP:0000831)2.00416104
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.99604637
105Arterial thrombosis (HP:0004420)1.99342561
106Chronic sinusitis (HP:0011109)1.97651199
107Absent/shortened dynein arms (HP:0200106)1.97496164
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.97496164
109Palpitations (HP:0001962)1.96963967
110Prolonged QT interval (HP:0001657)1.94672034
111Hypokalemic alkalosis (HP:0001949)1.94538918
112B lymphocytopenia (HP:0010976)1.91343605
113Abnormality of B cell number (HP:0010975)1.91343605
114Increased connective tissue (HP:0009025)1.90970902
115Large for gestational age (HP:0001520)1.90953680
116Anencephaly (HP:0002323)1.90935427
117Gastrointestinal stroma tumor (HP:0100723)1.90478140
118Ketoacidosis (HP:0001993)1.89133192
119Male pseudohermaphroditism (HP:0000037)1.89103002
120Syncope (HP:0001279)1.88004953
121Heart block (HP:0012722)1.87303407
122Medial flaring of the eyebrow (HP:0010747)1.83454888
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.81401613
124Tubulointerstitial nephritis (HP:0001970)1.77468152
125Renal salt wasting (HP:0000127)1.77221706
126Nephropathy (HP:0000112)1.70625693
127Tubular atrophy (HP:0000092)1.66951347
128Decreased central vision (HP:0007663)1.66196999
129Furrowed tongue (HP:0000221)1.64589219
130Sclerocornea (HP:0000647)1.64407355
131Bell-shaped thorax (HP:0001591)1.60810301
132Congenital primary aphakia (HP:0007707)1.60686827
133Oculomotor apraxia (HP:0000657)1.57747710
134Gait imbalance (HP:0002141)1.55562033
135Absent frontal sinuses (HP:0002688)1.52178645
136Hyperaldosteronism (HP:0000859)1.47984895
137Elevated erythrocyte sedimentation rate (HP:0003565)1.44568442
138Postaxial hand polydactyly (HP:0001162)1.42811845
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.39696308
140Nephrogenic diabetes insipidus (HP:0009806)1.38007409
141Abnormality of renin-angiotensin system (HP:0000847)1.35908522
142Abnormal drinking behavior (HP:0030082)1.35392526
143Polydipsia (HP:0001959)1.35392526
144Abnormality of the renal cortex (HP:0011035)1.35110724
145Purpura (HP:0000979)1.34087773
146Abnormality of chloride homeostasis (HP:0011422)1.30370837
147Prolonged bleeding time (HP:0003010)1.27945777
148Median cleft lip (HP:0000161)1.26538299
149Glucose intolerance (HP:0000833)1.22519752
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.19334097
151Tubulointerstitial abnormality (HP:0001969)1.18858772
152Stage 5 chronic kidney disease (HP:0003774)1.16912039
153Short thorax (HP:0010306)1.16259085
154Preaxial hand polydactyly (HP:0001177)1.13112640
155Abnormal biliary tract physiology (HP:0012439)1.10783082
156Bile duct proliferation (HP:0001408)1.10783082
157Dyschromatopsia (HP:0007641)1.08815803
158Hyponatremia (HP:0002902)1.08233950
159Short femoral neck (HP:0100864)1.07811145
160Tubulointerstitial fibrosis (HP:0005576)1.05612846
161Abnormality of the distal phalanges of the toes (HP:0010182)1.05258919
162Portal hypertension (HP:0001409)1.05023320
163Cone-rod dystrophy (HP:0000548)1.02205375
164Abnormality of the frontal sinuses (HP:0002687)1.00986042
165Fetal akinesia sequence (HP:0001989)1.00572598
166Poor coordination (HP:0002370)0.99899703
167Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.99300900
168Genital tract atresia (HP:0001827)0.96188327
169Vaginal atresia (HP:0000148)0.95574701
170Alveolar cell carcinoma (HP:0006519)0.95022682
171Abnormality of the hepatic vasculature (HP:0006707)0.94949869
172Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)0.94333261
173Abnormal rod and cone electroretinograms (HP:0008323)0.93599491
174Nonprogressive disorder (HP:0003680)0.92794990
175Polyuria (HP:0000103)0.92678866
176Retinitis pigmentosa (HP:0000510)0.92136552
177Aplasia/hypoplasia of the femur (HP:0005613)0.91771575
178Vascular calcification (HP:0004934)0.90517696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.15517732
2MAPK155.01843042
3IRAK33.77075016
4TXK3.28234840
5EPHA23.01917873
6TRIB32.49161127
7MAPKAPK32.25909082
8RIPK42.22660697
9INSRR2.17151350
10MAP3K142.15679432
11PTK2B2.15120141
12EPHB12.08023442
13OBSCN2.07685691
14DMPK2.06378220
15TTN2.02464027
16TSSK62.00063753
17RIPK11.96060275
18MAP4K11.92471064
19TEC1.84143323
20JAK11.81779342
21TLK11.81678628
22PHKG11.71674728
23PHKG21.71674728
24ITK1.71342419
25MST41.65020581
26MAP3K31.58975877
27EPHA31.57488921
28PKN21.53382385
29PTK61.48218325
30ZAP701.45214330
31NLK1.40682758
32FES1.37846614
33STK241.36313293
34TBK11.32296653
35HIPK21.27386022
36MAPKAPK51.26437316
37LRRK21.22397751
38BTK1.20424834
39JAK31.18792961
40TIE11.17696938
41MAP3K71.16762923
42EEF2K1.07817965
43TRPM71.05490346
44SMG11.02261685
45IRAK11.00716884
46GRK60.98498400
47PDGFRB0.96782885
48FGFR40.95992273
49PRKCQ0.95067901
50STK100.90585041
51IKBKE0.90274235
52FLT30.86536906
53FGFR30.86452044
54MAP3K20.86177340
55MAP2K20.84773908
56CHUK0.84724273
57BCR0.82338819
58PIM10.81561019
59GSK3A0.81392084
60RET0.79979453
61NME10.79036239
62SYK0.74552868
63PNCK0.72303048
64MAP2K30.68801119
65IKBKB0.68504517
66CAMKK10.67751371
67PRKD10.65969027
68HCK0.64379421
69ADRBK20.62803151
70BMPR20.62719902
71MATK0.62220809
72LYN0.60785215
73MAP4K20.58989373
74FER0.58945149
75MKNK20.58352760
76TYK20.58300526
77WNK10.57241896
78ILK0.56481507
79CDC42BPA0.55873148
80PRKCD0.55546328
81MYLK0.54750389
82ALK0.53401682
83CAMKK20.51542496
84BRD40.50359434
85PIM20.50208504
86CSK0.49291268
87NEK60.49198195
88JAK20.48288558
89TGFBR20.48025090
90ERBB20.47432248
91DYRK1B0.47081255
92PRKD30.46969309
93PTK20.46317707
94PRKAA20.45588910
95PINK10.44999495
96PRKCI0.44694039
97LMTK20.44587405
98TESK10.42469568
99ADRBK10.42277649
100CAMK1G0.42088405
101PKN10.41832859
102PASK0.40375566
103MELK0.40157423
104PRKD20.39994687
105VRK10.39571422
106TTK0.38901151
107LCK0.36871804
108CDK90.35508009
109MAPKAPK20.35404216
110GRK10.35214016
111IGF1R0.35134542
112CAMK2D0.35027950
113RPS6KA10.34058518
114SIK20.34041804
115PIK3CA0.33321732
116KDR0.33180479
117IRAK40.32522841
118MAPK120.32522410
119PRKCH0.32344579
120AURKA0.32337218
121BCKDK0.32199697
122WNK40.31852778
123GRK50.31844161
124PDPK10.31266274
125SIK10.30828853
126MARK20.30180685
127RPS6KA60.29567695
128PAK20.29563796
129ABL10.28699187
130FYN0.27397878
131MUSK0.27062799
132SGK30.26792884
133TNK20.26518537
134BMX0.25916832
135PRKCA0.23932699
136CSF1R0.23477054
137MAP3K120.22432937
138PDK10.21663377
139MAP2K60.20389859
140CAMK2G0.19121031
141SRC0.18469236
142MAPK130.17709062
143PRKACA0.17533531
144BLK0.17310205
145TAOK10.17112123
146ERBB30.16190439
147OXSR10.15816148
148SGK10.14451896
149MAP2K10.14424000

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.63339714
2Circadian rhythm_Homo sapiens_hsa047104.58691552
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.19972147
4Chemical carcinogenesis_Homo sapiens_hsa052043.88741119
5Phenylalanine metabolism_Homo sapiens_hsa003603.67394801
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.55986968
7Histidine metabolism_Homo sapiens_hsa003403.18741889
8Tyrosine metabolism_Homo sapiens_hsa003503.13403513
9Osteoclast differentiation_Homo sapiens_hsa043802.64401661
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.58332477
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.50986055
12Linoleic acid metabolism_Homo sapiens_hsa005912.42665140
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19537527
14beta-Alanine metabolism_Homo sapiens_hsa004102.16260927
15Huntingtons disease_Homo sapiens_hsa050162.15325875
16Allograft rejection_Homo sapiens_hsa053302.13702606
17Glutathione metabolism_Homo sapiens_hsa004802.13291537
18Primary immunodeficiency_Homo sapiens_hsa053402.08379306
19Caffeine metabolism_Homo sapiens_hsa002322.03576651
20Autoimmune thyroid disease_Homo sapiens_hsa053202.01921047
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99075268
22T cell receptor signaling pathway_Homo sapiens_hsa046601.90104720
23Graft-versus-host disease_Homo sapiens_hsa053321.85527844
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76758586
25Asthma_Homo sapiens_hsa053101.73419917
26Insulin resistance_Homo sapiens_hsa049311.71129513
27Prolactin signaling pathway_Homo sapiens_hsa049171.69133968
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.66977493
29Dilated cardiomyopathy_Homo sapiens_hsa054141.65246113
30TNF signaling pathway_Homo sapiens_hsa046681.62551876
31Arachidonic acid metabolism_Homo sapiens_hsa005901.62286012
32Type I diabetes mellitus_Homo sapiens_hsa049401.58338370
33Type II diabetes mellitus_Homo sapiens_hsa049301.54458807
34B cell receptor signaling pathway_Homo sapiens_hsa046621.52658500
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44049342
36Antigen processing and presentation_Homo sapiens_hsa046121.41579100
37Sphingolipid metabolism_Homo sapiens_hsa006001.35643789
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32674808
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.31024083
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30760412
41Protein export_Homo sapiens_hsa030601.29408557
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25493615
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22691754
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22032746
45Sulfur metabolism_Homo sapiens_hsa009201.20260576
46Leishmaniasis_Homo sapiens_hsa051401.19974534
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.19769131
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18446421
49Insulin secretion_Homo sapiens_hsa049111.18048255
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16844697
51Rheumatoid arthritis_Homo sapiens_hsa053231.15993643
52Dorso-ventral axis formation_Homo sapiens_hsa043201.15922684
53Glucagon signaling pathway_Homo sapiens_hsa049221.13955944
54Measles_Homo sapiens_hsa051621.13712759
55Toxoplasmosis_Homo sapiens_hsa051451.12846408
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.11343477
57Estrogen signaling pathway_Homo sapiens_hsa049151.08810760
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.08014859
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05357316
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00939727
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00382781
62Acute myeloid leukemia_Homo sapiens_hsa052210.97693991
63FoxO signaling pathway_Homo sapiens_hsa040680.97480790
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96615369
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96365350
66MAPK signaling pathway_Homo sapiens_hsa040100.93510955
67Salivary secretion_Homo sapiens_hsa049700.93360645
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.91036127
69Cocaine addiction_Homo sapiens_hsa050300.90744188
70Phototransduction_Homo sapiens_hsa047440.89675931
71Peroxisome_Homo sapiens_hsa041460.88941623
72Cardiac muscle contraction_Homo sapiens_hsa042600.87084407
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.86096261
74Hematopoietic cell lineage_Homo sapiens_hsa046400.85604969
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83737637
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83468525
77Notch signaling pathway_Homo sapiens_hsa043300.81614748
78Renal cell carcinoma_Homo sapiens_hsa052110.81598753
79Insulin signaling pathway_Homo sapiens_hsa049100.81308285
80Fatty acid degradation_Homo sapiens_hsa000710.81224722
81Arginine and proline metabolism_Homo sapiens_hsa003300.80529090
82Legionellosis_Homo sapiens_hsa051340.80249290
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79634637
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77831627
85Chemokine signaling pathway_Homo sapiens_hsa040620.76153414
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75519246
87Collecting duct acid secretion_Homo sapiens_hsa049660.75368298
88Focal adhesion_Homo sapiens_hsa045100.74033770
89Starch and sucrose metabolism_Homo sapiens_hsa005000.73125303
90Choline metabolism in cancer_Homo sapiens_hsa052310.72787132
91Viral myocarditis_Homo sapiens_hsa054160.71032149
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70649438
93Olfactory transduction_Homo sapiens_hsa047400.69635076
94Nitrogen metabolism_Homo sapiens_hsa009100.69379482
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67355366
96Tight junction_Homo sapiens_hsa045300.66672158
97Staphylococcus aureus infection_Homo sapiens_hsa051500.64221148
98Hepatitis C_Homo sapiens_hsa051600.63523948
99Apoptosis_Homo sapiens_hsa042100.63424219
100VEGF signaling pathway_Homo sapiens_hsa043700.61347699
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.60862618
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60618727
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60394907
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59801914
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.59170597
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59072794
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58380822
108Platelet activation_Homo sapiens_hsa046110.57723208
109HIF-1 signaling pathway_Homo sapiens_hsa040660.57187423
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56748010
111HTLV-I infection_Homo sapiens_hsa051660.56697044
112cAMP signaling pathway_Homo sapiens_hsa040240.55618501
113Amphetamine addiction_Homo sapiens_hsa050310.54915164
114AMPK signaling pathway_Homo sapiens_hsa041520.54834767
115Alzheimers disease_Homo sapiens_hsa050100.54515098
116Chronic myeloid leukemia_Homo sapiens_hsa052200.53646825
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52077830
118Malaria_Homo sapiens_hsa051440.51366566
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.50762539
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48353644
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48127477
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46415923
123Serotonergic synapse_Homo sapiens_hsa047260.46405329
124Pancreatic cancer_Homo sapiens_hsa052120.45497521
125Adherens junction_Homo sapiens_hsa045200.45230172
126Oxytocin signaling pathway_Homo sapiens_hsa049210.45146408
127Epstein-Barr virus infection_Homo sapiens_hsa051690.45122668
128Gastric acid secretion_Homo sapiens_hsa049710.44697800
129Retinol metabolism_Homo sapiens_hsa008300.43905562
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40489177
131Taste transduction_Homo sapiens_hsa047420.40487773
132Galactose metabolism_Homo sapiens_hsa000520.40302650
133Calcium signaling pathway_Homo sapiens_hsa040200.39717050
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38841112
135Hepatitis B_Homo sapiens_hsa051610.38840166
136Influenza A_Homo sapiens_hsa051640.37948447
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37654910
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37452035
139Ether lipid metabolism_Homo sapiens_hsa005650.36235299
140ABC transporters_Homo sapiens_hsa020100.36112130
141Endocytosis_Homo sapiens_hsa041440.35962177
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35297924
143Renin secretion_Homo sapiens_hsa049240.34608495
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34233809
145Glycerolipid metabolism_Homo sapiens_hsa005610.34017693
146Prostate cancer_Homo sapiens_hsa052150.33681704
147Oxidative phosphorylation_Homo sapiens_hsa001900.33432867
148Lysosome_Homo sapiens_hsa041420.33421361
149Phagosome_Homo sapiens_hsa041450.32178264
150Amoebiasis_Homo sapiens_hsa051460.31361534
151Lysine degradation_Homo sapiens_hsa003100.30335708
152Regulation of autophagy_Homo sapiens_hsa041400.30098717
153Other glycan degradation_Homo sapiens_hsa005110.29599946
154Systemic lupus erythematosus_Homo sapiens_hsa053220.28661468
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27978247
156Herpes simplex infection_Homo sapiens_hsa051680.27886278
157Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23620060
158African trypanosomiasis_Homo sapiens_hsa051430.22337995
159Tuberculosis_Homo sapiens_hsa051520.21666608

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