PRR26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, GABAergic (GO:0032230)8.23115610
2regulation of glucocorticoid secretion (GO:2000849)8.10709275
3negative regulation of heart rate (GO:0010459)7.98561098
4positive regulation of steroid hormone secretion (GO:2000833)7.86627660
5regulation of action potential (GO:0098900)6.97087828
6regulation of corticosteroid hormone secretion (GO:2000846)6.81441282
7positive regulation of renal sodium excretion (GO:0035815)5.56696368
8regulation of steroid hormone secretion (GO:2000831)4.93833488
9regulation of digestive system process (GO:0044058)4.39869997
10long-term memory (GO:0007616)4.08166613
11establishment of protein localization to Golgi (GO:0072600)3.93259183
12regulation of synaptic transmission, GABAergic (GO:0032228)3.91009767
13negative regulation of heart contraction (GO:0045822)3.73795626
14regulation of renal sodium excretion (GO:0035813)3.69666795
15protein targeting to Golgi (GO:0000042)3.45929371
16response to isoquinoline alkaloid (GO:0014072)3.41013598
17response to morphine (GO:0043278)3.40417723
18positive regulation of vesicle fusion (GO:0031340)3.34958693
19response to pheromone (GO:0019236)3.30630153
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.29442439
21L-glutamate transport (GO:0015813)3.25963790
22regulation of excretion (GO:0044062)3.20737086
23response to pain (GO:0048265)3.19949070
24acidic amino acid transport (GO:0015800)3.14367703
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10767911
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.10767911
27regulation of translation, ncRNA-mediated (GO:0045974)3.10767911
28neuronal action potential propagation (GO:0019227)3.07684916
29presynaptic membrane assembly (GO:0097105)3.05964066
30somite rostral/caudal axis specification (GO:0032525)3.00378491
31negative regulation of blood circulation (GO:1903523)2.94817343
32axonal fasciculation (GO:0007413)2.94575787
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93673650
34microtubule nucleation (GO:0007020)2.91741130
35regulation of male gonad development (GO:2000018)2.87115461
36microtubule anchoring (GO:0034453)2.85123340
37startle response (GO:0001964)2.84439932
38sensory perception of pain (GO:0019233)2.82263602
39regulation of endocrine process (GO:0044060)2.81126818
40protein localization to Golgi apparatus (GO:0034067)2.74346265
41regulation of clathrin-mediated endocytosis (GO:2000369)2.72333143
42behavioral response to nicotine (GO:0035095)2.66231831
43regulation of collateral sprouting (GO:0048670)2.66130322
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65260385
45presynaptic membrane organization (GO:0097090)2.64913994
46central nervous system projection neuron axonogenesis (GO:0021952)2.60959820
47adaptation of signaling pathway (GO:0023058)2.60947942
48positive regulation of male gonad development (GO:2000020)2.60681771
49C4-dicarboxylate transport (GO:0015740)2.59434712
50positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.57450002
51synapse assembly (GO:0007416)2.54454471
52early endosome to late endosome transport (GO:0045022)2.53793203
53flavonoid metabolic process (GO:0009812)2.53347056
54ionotropic glutamate receptor signaling pathway (GO:0035235)2.50345595
55transepithelial transport (GO:0070633)2.49342913
56synaptic transmission, glutamatergic (GO:0035249)2.48586092
57chemosensory behavior (GO:0007635)2.47015228
58neuron recognition (GO:0008038)2.47006039
59glutamate receptor signaling pathway (GO:0007215)2.46285474
60dermatan sulfate biosynthetic process (GO:0030208)2.46000080
61vocalization behavior (GO:0071625)2.44041521
62cilium or flagellum-dependent cell motility (GO:0001539)2.43867293
63retinal ganglion cell axon guidance (GO:0031290)2.42631010
64central nervous system neuron axonogenesis (GO:0021955)2.40901863
65neural tube formation (GO:0001841)2.39703583
66detection of light stimulus involved in visual perception (GO:0050908)2.37419255
67detection of light stimulus involved in sensory perception (GO:0050962)2.37419255
68nephron epithelium morphogenesis (GO:0072088)2.37335865
69nephron tubule morphogenesis (GO:0072078)2.37335865
70regulation of pigment cell differentiation (GO:0050932)2.36710002
71centrosome localization (GO:0051642)2.35412019
72neuronal ion channel clustering (GO:0045161)2.34848316
73sex differentiation (GO:0007548)2.34701595
74embryonic foregut morphogenesis (GO:0048617)2.33687718
75membrane depolarization during action potential (GO:0086010)2.32907737
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32795083
77neuron cell-cell adhesion (GO:0007158)2.32514438
78neurotransmitter-gated ion channel clustering (GO:0072578)2.32472753
79synaptic vesicle exocytosis (GO:0016079)2.31856220
80renal tubule morphogenesis (GO:0061333)2.30781821
81spinal cord motor neuron differentiation (GO:0021522)2.28417312
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.27687776
83regulation of protein kinase A signaling (GO:0010738)2.26544364
84somite development (GO:0061053)2.25314818
85S-adenosylmethionine metabolic process (GO:0046500)2.24690878
86prenylation (GO:0097354)2.24484529
87protein prenylation (GO:0018342)2.24484529
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.24373149
89gamma-aminobutyric acid transport (GO:0015812)2.23911611
90cellular ketone body metabolic process (GO:0046950)2.23568530
91positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.23534371
92cell differentiation involved in metanephros development (GO:0072202)2.23004275
93retinal cone cell development (GO:0046549)2.22995285
94retina layer formation (GO:0010842)2.20361591
95neuropeptide signaling pathway (GO:0007218)2.19097538
96regulation of telomere maintenance (GO:0032204)2.17398232
97interkinetic nuclear migration (GO:0022027)2.16501103
98tachykinin receptor signaling pathway (GO:0007217)13.5200783
99positive regulation of action potential (GO:0045760)11.9066976
100positive regulation of digestive system process (GO:0060456)10.6288381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.42439495
2EZH2_22144423_ChIP-Seq_EOC_Human2.93175780
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76921632
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.63585810
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55071174
6IGF1R_20145208_ChIP-Seq_DFB_Human2.51184710
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47437766
8VDR_22108803_ChIP-Seq_LS180_Human2.40712487
9FUS_26573619_Chip-Seq_HEK293_Human2.35061181
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26091437
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24808114
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18789655
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.18700416
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08809691
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.06484454
16TAF15_26573619_Chip-Seq_HEK293_Human2.06235435
17P300_19829295_ChIP-Seq_ESCs_Human2.02940537
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97684315
19SMAD4_21799915_ChIP-Seq_A2780_Human1.94677541
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.90894901
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87222280
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82384202
23AHR_22903824_ChIP-Seq_MCF-7_Human1.80042645
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78248591
25STAT3_23295773_ChIP-Seq_U87_Human1.71540501
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.70323714
27ZNF274_21170338_ChIP-Seq_K562_Hela1.70288161
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70118857
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70118857
30ER_23166858_ChIP-Seq_MCF-7_Human1.69947038
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.66115151
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56808083
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.56030433
34AR_21572438_ChIP-Seq_LNCaP_Human1.53920154
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53818855
36EWS_26573619_Chip-Seq_HEK293_Human1.53671070
37TCF4_23295773_ChIP-Seq_U87_Human1.52394473
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51838850
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51049665
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50747652
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50389572
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49528202
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49301804
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49276070
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49161067
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48719790
47RNF2_27304074_Chip-Seq_NSC_Mouse1.46335270
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44656210
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44284186
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43749991
51REST_21632747_ChIP-Seq_MESCs_Mouse1.42793422
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42463343
53BCAT_22108803_ChIP-Seq_LS180_Human1.42385006
54DROSHA_22980978_ChIP-Seq_HELA_Human1.42093286
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42015159
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40971372
57RUNX2_22187159_ChIP-Seq_PCA_Human1.40868071
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40029922
59CBP_20019798_ChIP-Seq_JUKART_Human1.37120424
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37120424
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.36669554
62AR_25329375_ChIP-Seq_VCAP_Human1.36041263
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33877982
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.33185708
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.29862030
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27126654
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26868508
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26730436
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26521877
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.24605641
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.23967470
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.23603546
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23551641
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22836304
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.22361474
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20728500
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.20588781
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19740247
79TCF4_22108803_ChIP-Seq_LS180_Human1.18616982
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18110827
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17104347
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.16731763
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.16303145
84RXR_22108803_ChIP-Seq_LS180_Human1.14653262
85P53_22387025_ChIP-Seq_ESCs_Mouse1.13755309
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13645008
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.13532443
88KDM2B_26808549_Chip-Seq_REH_Human1.13371586
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13229420
90TP53_16413492_ChIP-PET_HCT116_Human1.12525524
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12466129
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11797946
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11483702
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10867293
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09829677
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08168102
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07844256
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07346491
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.06348288
100AR_19668381_ChIP-Seq_PC3_Human1.05502192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder9.75347883
2MP0003879_abnormal_hair_cell3.00758299
3MP0004270_analgesia2.79842288
4MP0003195_calcinosis2.62431847
5MP0002735_abnormal_chemical_nociception2.43647782
6MP0001968_abnormal_touch/_nociception2.34606132
7MP0001486_abnormal_startle_reflex2.19747804
8MP0002272_abnormal_nervous_system2.10388296
9MP0000569_abnormal_digit_pigmentation2.05104815
10MP0001756_abnormal_urination2.02155935
11MP0009046_muscle_twitch1.92898441
12MP0009745_abnormal_behavioral_response1.92523157
13MP0004859_abnormal_synaptic_plasticity1.89913138
14MP0001970_abnormal_pain_threshold1.89844777
15MP0005670_abnormal_white_adipose1.82787582
16MP0003787_abnormal_imprinting1.82210010
17MP0003635_abnormal_synaptic_transmissio1.81561422
18MP0001501_abnormal_sleep_pattern1.73126046
19MP0002734_abnormal_mechanical_nocicepti1.71661776
20MP0002064_seizures1.70876808
21MP0005187_abnormal_penis_morphology1.69219631
22MP0002572_abnormal_emotion/affect_behav1.64107430
23MP0009780_abnormal_chondrocyte_physiolo1.61032104
24MP0001188_hyperpigmentation1.59289429
25MP0002736_abnormal_nociception_after1.57623500
26MP0003950_abnormal_plasma_membrane1.54654370
27MP0004133_heterotaxia1.53249199
28MP0004043_abnormal_pH_regulation1.52794728
29MP0000778_abnormal_nervous_system1.49206783
30MP0005551_abnormal_eye_electrophysiolog1.46881497
31MP0002184_abnormal_innervation1.46575895
32MP0004885_abnormal_endolymph1.45750482
33MP0008877_abnormal_DNA_methylation1.44504511
34MP0005646_abnormal_pituitary_gland1.40187081
35MP0002909_abnormal_adrenal_gland1.39546314
36MP0000538_abnormal_urinary_bladder1.37674474
37MP0006276_abnormal_autonomic_nervous1.35331485
38MP0001984_abnormal_olfaction1.34695914
39MP0003890_abnormal_embryonic-extraembry1.34444355
40MP0000631_abnormal_neuroendocrine_gland1.32912813
41MP0002067_abnormal_sensory_capabilities1.28417330
42MP0003121_genomic_imprinting1.25778866
43MP0003123_paternal_imprinting1.24520583
44MP0001485_abnormal_pinna_reflex1.21843734
45MP0002063_abnormal_learning/memory/cond1.21839135
46MP0004142_abnormal_muscle_tone1.20185972
47MP0003646_muscle_fatigue1.20159748
48MP0002733_abnormal_thermal_nociception1.16438047
49MP0003252_abnormal_bile_duct1.13486004
50MP0000427_abnormal_hair_cycle1.11742851
51MP0008872_abnormal_physiological_respon1.10105831
52MP0005386_behavior/neurological_phenoty1.08825253
53MP0004924_abnormal_behavior1.08825253
54MP0005253_abnormal_eye_physiology1.07930304
55MP0002557_abnormal_social/conspecific_i1.06907061
56MP0002751_abnormal_autonomic_nervous1.05003624
57MP0002837_dystrophic_cardiac_calcinosis1.03115855
58MP0003136_yellow_coat_color1.01232810
59MP0002882_abnormal_neuron_morphology0.98022838
60MP0006072_abnormal_retinal_apoptosis0.96550189
61MP0003122_maternal_imprinting0.96288572
62MP0001529_abnormal_vocalization0.96236574
63MP0005423_abnormal_somatic_nervous0.92825419
64MP0003880_abnormal_central_pattern0.92614935
65MP0003283_abnormal_digestive_organ0.91304125
66MP0002234_abnormal_pharynx_morphology0.90369584
67MP0002822_catalepsy0.90283060
68MP0000955_abnormal_spinal_cord0.87826477
69MP0002752_abnormal_somatic_nervous0.85788529
70MP0000639_abnormal_adrenal_gland0.84537461
71MP0001963_abnormal_hearing_physiology0.84320480
72MP0002229_neurodegeneration0.84121119
73MP0004145_abnormal_muscle_electrophysio0.83873821
74MP0002638_abnormal_pupillary_reflex0.83794449
75MP0005367_renal/urinary_system_phenotyp0.80104572
76MP0000516_abnormal_urinary_system0.80104572
77MP0004742_abnormal_vestibular_system0.78681028
78MP0004085_abnormal_heartbeat0.77423078
79MP0002066_abnormal_motor_capabilities/c0.74820948
80MP0002160_abnormal_reproductive_system0.74707916
81MP0000026_abnormal_inner_ear0.74318456
82MP0003119_abnormal_digestive_system0.72621528
83MP0005645_abnormal_hypothalamus_physiol0.71481261
84MP0003137_abnormal_impulse_conducting0.70780108
85MP0001664_abnormal_digestion0.69951461
86MP0001905_abnormal_dopamine_level0.69447670
87MP0002876_abnormal_thyroid_physiology0.69309034
88MP0001666_abnormal_nutrient_absorption0.69237649
89MP0000015_abnormal_ear_pigmentation0.69231451
90MP0001440_abnormal_grooming_behavior0.68873955
91MP0001299_abnormal_eye_distance/0.68684187
92MP0005195_abnormal_posterior_eye0.68085462
93MP0001986_abnormal_taste_sensitivity0.67468862
94MP0005174_abnormal_tail_pigmentation0.67210498
95MP0000013_abnormal_adipose_tissue0.67080520
96MP0005085_abnormal_gallbladder_physiolo0.65694922
97MP0005410_abnormal_fertilization0.65515592
98MP0004215_abnormal_myocardial_fiber0.65260695
99MP0001944_abnormal_pancreas_morphology0.64794872
100MP0002928_abnormal_bile_duct0.64760801

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.68670580
2Genetic anticipation (HP:0003743)5.33678943
3Broad-based gait (HP:0002136)5.02629660
4Protruding tongue (HP:0010808)4.44238311
5Progressive cerebellar ataxia (HP:0002073)4.19036948
6Fair hair (HP:0002286)3.84806931
7Hip dysplasia (HP:0001385)3.63932071
8Gaze-evoked nystagmus (HP:0000640)3.60684732
9Thoracolumbar scoliosis (HP:0002944)3.56968657
10Clumsiness (HP:0002312)3.51746282
11Increased density of long bones (HP:0006392)3.41138426
12Drooling (HP:0002307)3.32119002
13Hypoplastic ischia (HP:0003175)3.19362774
14Aplasia/Hypoplasia of the tibia (HP:0005772)3.17473243
15Abnormality of the ischium (HP:0003174)3.17407800
16Generalized hypopigmentation of hair (HP:0011358)3.14598153
17Febrile seizures (HP:0002373)3.02024416
18Excessive salivation (HP:0003781)3.00392088
19Absent speech (HP:0001344)2.99081651
20Calf muscle hypertrophy (HP:0008981)2.87190479
21Exotropia (HP:0000577)2.86028479
22Inappropriate behavior (HP:0000719)2.78817603
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75198471
24Blue irides (HP:0000635)2.71435957
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.61313056
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61313056
27Hemiparesis (HP:0001269)2.51328005
28Urinary bladder sphincter dysfunction (HP:0002839)2.50389372
29Nephronophthisis (HP:0000090)2.49948943
30Muscle hypertrophy of the lower extremities (HP:0008968)2.44509744
31Widely spaced teeth (HP:0000687)2.35492693
32Congenital stationary night blindness (HP:0007642)2.32964226
33Abnormality of the labia minora (HP:0012880)2.30379077
34Neoplasm of the heart (HP:0100544)2.29465514
35Proximal tubulopathy (HP:0000114)2.28956000
36Epileptic encephalopathy (HP:0200134)2.27977453
37Focal seizures (HP:0007359)2.26479329
38True hermaphroditism (HP:0010459)2.25065783
39Abnormality of the renal medulla (HP:0100957)2.20208133
40Short tibia (HP:0005736)2.20125383
41Abnormality of the renal cortex (HP:0011035)2.19766930
42Intellectual disability, severe (HP:0010864)2.18801050
43Macroglossia (HP:0000158)2.18301532
44Dialeptic seizures (HP:0011146)2.16455561
45Macroorchidism (HP:0000053)2.14675371
46Intellectual disability, progressive (HP:0006887)2.11808852
47Agitation (HP:0000713)2.11770401
48Atonic seizures (HP:0010819)2.10662589
49Renal cortical cysts (HP:0000803)2.09501523
50Pancreatic cysts (HP:0001737)2.08771635
51Absence seizures (HP:0002121)2.06951035
52Shawl scrotum (HP:0000049)2.05336625
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03741123
54Short 1st metacarpal (HP:0010034)2.03741123
55Hypoplastic labia majora (HP:0000059)2.02552199
56Tubulointerstitial nephritis (HP:0001970)1.98035417
57Tubular atrophy (HP:0000092)1.97272969
58Tented upper lip vermilion (HP:0010804)1.97121176
59Inability to walk (HP:0002540)1.94782557
60Molar tooth sign on MRI (HP:0002419)1.94659226
61Abnormality of midbrain morphology (HP:0002418)1.94659226
62Intestinal atresia (HP:0011100)1.93641164
63Prolonged QT interval (HP:0001657)1.90590737
64Abnormality of the corticospinal tract (HP:0002492)1.90524395
65Prominent nose (HP:0000448)1.87378932
66Difficulty running (HP:0009046)1.85291332
67Fibular aplasia (HP:0002990)1.84003629
68Short phalanx of the thumb (HP:0009660)1.83855728
69Decreased muscle mass (HP:0003199)1.83511956
70Pancreatic fibrosis (HP:0100732)1.82895319
71Hypophosphatemic rickets (HP:0004912)1.81919320
72Abnormality of the labia majora (HP:0012881)1.81715522
73Focal motor seizures (HP:0011153)1.79523320
74Abnormality of macular pigmentation (HP:0008002)1.79009362
75Abnormality of the 1st metacarpal (HP:0010009)1.78582497
76Epileptiform EEG discharges (HP:0011182)1.78436792
77Aplasia/Hypoplasia of the patella (HP:0006498)1.77807981
78EEG with generalized epileptiform discharges (HP:0011198)1.77594099
79Large for gestational age (HP:0001520)1.74040405
80Submucous cleft hard palate (HP:0000176)1.73653467
81Attenuation of retinal blood vessels (HP:0007843)1.73177375
82Type II lissencephaly (HP:0007260)1.72918352
83Decreased central vision (HP:0007663)1.72709280
84Hypsarrhythmia (HP:0002521)1.71875389
85Poor eye contact (HP:0000817)1.67667242
86Heterotopia (HP:0002282)1.67496433
87Rib fusion (HP:0000902)1.66870887
88Astrocytoma (HP:0009592)1.66508674
89Abnormality of the astrocytes (HP:0100707)1.66508674
90Impaired vibratory sensation (HP:0002495)1.66482450
91Hypoplastic nipples (HP:0002557)1.65748700
92Patellar aplasia (HP:0006443)1.64365032
93Microtia (HP:0008551)1.62169132
94Abnormal social behavior (HP:0012433)1.61659104
95Impaired social interactions (HP:0000735)1.61659104
96Enlarged epiphyses (HP:0010580)1.61307300
97Abnormality of the pubic bones (HP:0003172)1.60712151
98Abnormality of salivation (HP:0100755)1.60253308
99Bulbous nose (HP:0000414)1.59160789
100Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58907429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.89873635
2AKT34.27845793
3MAP3K43.82106547
4CASK3.60557234
5MARK13.09599818
6MAP2K73.08388136
7MAPK132.47608935
8STK38L2.42526746
9NTRK32.38377188
10INSRR2.15503612
11BMPR1B2.10027446
12SGK22.01449645
13PINK11.93974556
14SGK2231.64553458
15SGK4941.64553458
16GRK11.54328559
17MAP4K21.53088869
18MAP2K41.49424205
19ACVR1B1.46113150
20PRKCE1.43232020
21LATS11.33828479
22SIK21.31687677
23DYRK31.27806963
24PAK31.24448085
25TNIK1.15870822
26PKN21.15756910
27CAMK1D1.13064559
28CAMK1G1.11065532
29SGK31.05860032
30ADRBK21.04652773
31WNK31.04645837
32STK381.00177610
33WNK10.97514295
34CSNK1A1L0.97010335
35CSNK1G20.89117112
36NLK0.87495962
37MYLK0.85387646
38MAP3K60.82725597
39DMPK0.81115438
40MAPKAPK30.80889492
41BCR0.80342546
42PIK3CA0.79424074
43WNK40.78873045
44DAPK20.78256005
45UHMK10.77376514
46PRKCZ0.77180556
47ROCK10.75483537
48CAMK40.72059637
49FGFR20.67439389
50TIE10.67347762
51PLK20.67042616
52PRKCG0.66377293
53MKNK20.66286419
54OBSCN0.65367130
55PRKAA10.64533570
56TRPM70.63633218
57CDK50.62972516
58STK30.62881955
59PRKG10.61641817
60PTK2B0.60610527
61CAMK2B0.59765456
62CSNK1G10.58703036
63RPS6KA20.58409163
64STK390.58193302
65CAMK2A0.57943609
66MAP3K70.57712018
67STK110.57662562
68OXSR10.56821670
69TAOK10.56301179
70NTRK20.55730830
71PRKCH0.52193701
72DYRK20.51940781
73PHKG10.51062527
74PHKG20.51062527
75PRKAA20.50974921
76CSNK1A10.50604629
77SGK10.50378634
78ADRBK10.50262021
79STK240.48272890
80CDK120.47974697
81PRKACA0.47889602
82CAMK2D0.47116251
83ERBB20.47070312
84FLT30.46727355
85MARK30.46328445
86DYRK1A0.44842735
87CSNK1G30.44546634
88CHUK0.44012925
89RPS6KB10.43079177
90PRKACB0.42665170
91CAMK10.41596438
92TGFBR10.41295605
93PNCK0.40876389
94RPS6KA30.40690726
95PKN10.39328075
96CSNK1D0.38441338
97ERBB30.38248850
98RPS6KA40.37671578
99PRKD20.35155715
100PRKD30.34782885

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.92054165
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.58998039
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41530031
4Taste transduction_Homo sapiens_hsa047422.37353189
5Glutamatergic synapse_Homo sapiens_hsa047242.24249491
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22233097
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00866029
8Butanoate metabolism_Homo sapiens_hsa006501.95086432
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.89561373
10Synaptic vesicle cycle_Homo sapiens_hsa047211.89446158
11Insulin secretion_Homo sapiens_hsa049111.87034906
12Cocaine addiction_Homo sapiens_hsa050301.83330826
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76849815
14Circadian rhythm_Homo sapiens_hsa047101.70107453
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70082657
16Circadian entrainment_Homo sapiens_hsa047131.64298269
17GABAergic synapse_Homo sapiens_hsa047271.63993737
18Regulation of autophagy_Homo sapiens_hsa041401.56019266
19Morphine addiction_Homo sapiens_hsa050321.54767727
20ABC transporters_Homo sapiens_hsa020101.52331055
21Phototransduction_Homo sapiens_hsa047441.51037289
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.40321956
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36917791
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36833369
25Type II diabetes mellitus_Homo sapiens_hsa049301.33529905
26Bile secretion_Homo sapiens_hsa049761.27263350
27Dorso-ventral axis formation_Homo sapiens_hsa043201.27034190
28Amphetamine addiction_Homo sapiens_hsa050311.26707653
29Retinol metabolism_Homo sapiens_hsa008301.25594856
30Linoleic acid metabolism_Homo sapiens_hsa005911.24113153
31Dopaminergic synapse_Homo sapiens_hsa047281.24020474
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23114805
33Long-term depression_Homo sapiens_hsa047301.09613734
34Renin secretion_Homo sapiens_hsa049241.09496033
35Serotonergic synapse_Homo sapiens_hsa047261.07459478
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.06742016
37Calcium signaling pathway_Homo sapiens_hsa040201.05884016
38Salivary secretion_Homo sapiens_hsa049701.04001962
39Chemical carcinogenesis_Homo sapiens_hsa052041.03735233
40cAMP signaling pathway_Homo sapiens_hsa040241.02991592
41Starch and sucrose metabolism_Homo sapiens_hsa005001.02877210
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02837430
43Tryptophan metabolism_Homo sapiens_hsa003800.96672771
44Nitrogen metabolism_Homo sapiens_hsa009100.95942597
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95365251
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94766195
47Histidine metabolism_Homo sapiens_hsa003400.93688697
48Caffeine metabolism_Homo sapiens_hsa002320.91958873
49Sphingolipid metabolism_Homo sapiens_hsa006000.88022570
50Cholinergic synapse_Homo sapiens_hsa047250.87713979
51Ether lipid metabolism_Homo sapiens_hsa005650.86809081
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86270870
53Olfactory transduction_Homo sapiens_hsa047400.82154924
54Protein export_Homo sapiens_hsa030600.81451642
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79339698
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75910734
57Mineral absorption_Homo sapiens_hsa049780.74316280
58Lysine degradation_Homo sapiens_hsa003100.73677973
59Ovarian steroidogenesis_Homo sapiens_hsa049130.72911860
60Propanoate metabolism_Homo sapiens_hsa006400.72847108
61Thyroid hormone synthesis_Homo sapiens_hsa049180.72268883
62Axon guidance_Homo sapiens_hsa043600.70813010
63Gastric acid secretion_Homo sapiens_hsa049710.70808736
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68706539
65Selenocompound metabolism_Homo sapiens_hsa004500.68622736
66Glycerolipid metabolism_Homo sapiens_hsa005610.67391143
67beta-Alanine metabolism_Homo sapiens_hsa004100.66648641
68TGF-beta signaling pathway_Homo sapiens_hsa043500.66044751
69Fatty acid biosynthesis_Homo sapiens_hsa000610.64771869
70Pancreatic secretion_Homo sapiens_hsa049720.64748561
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63235884
72Hedgehog signaling pathway_Homo sapiens_hsa043400.63220957
73Insulin resistance_Homo sapiens_hsa049310.61174421
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59894710
75Fat digestion and absorption_Homo sapiens_hsa049750.59734060
76Vitamin digestion and absorption_Homo sapiens_hsa049770.58827082
77Oxytocin signaling pathway_Homo sapiens_hsa049210.57562117
78AMPK signaling pathway_Homo sapiens_hsa041520.57251562
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.56616095
80Hippo signaling pathway_Homo sapiens_hsa043900.55012743
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53725477
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50762699
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48878270
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48825418
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48149448
86Sulfur metabolism_Homo sapiens_hsa009200.47781372
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47767283
88PPAR signaling pathway_Homo sapiens_hsa033200.47178289
89Dilated cardiomyopathy_Homo sapiens_hsa054140.46845227
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44115648
91Glucagon signaling pathway_Homo sapiens_hsa049220.43733797
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43377881
93Arachidonic acid metabolism_Homo sapiens_hsa005900.42694881
94Complement and coagulation cascades_Homo sapiens_hsa046100.40987525
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40482084
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40234308
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39884531
98Ras signaling pathway_Homo sapiens_hsa040140.39809546
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39255318
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39027658

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