PRR25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)9.07876148
2cellular response to ATP (GO:0071318)9.07773194
3regulation of skeletal muscle contraction (GO:0014819)8.05525626
4negative regulation of cell aging (GO:0090344)7.86536722
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)7.26130185
6meiotic chromosome segregation (GO:0045132)7.18633709
7adenosine receptor signaling pathway (GO:0001973)6.68044248
8regulation of synapse structural plasticity (GO:0051823)6.61804285
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.33822015
10purinergic nucleotide receptor signaling pathway (GO:0035590)5.99191892
11lens fiber cell differentiation (GO:0070306)5.60277319
12rRNA methylation (GO:0031167)5.59573613
13mitotic cell cycle arrest (GO:0071850)5.50343645
14peptidyl-glutamic acid carboxylation (GO:0017187)5.47704303
15protein carboxylation (GO:0018214)5.47704303
16rRNA modification (GO:0000154)5.11012953
17regulation of cytokine production involved in inflammatory response (GO:1900015)5.10519338
18response to ATP (GO:0033198)5.09323231
19positive regulation of protein kinase C signaling (GO:0090037)4.89496628
20sensory perception of taste (GO:0050909)4.86869526
21nucleotide-sugar biosynthetic process (GO:0009226)4.64086453
22positive regulation of megakaryocyte differentiation (GO:0045654)4.60577202
23nucleotide transmembrane transport (GO:1901679)4.53563640
24positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.45142359
25adenine nucleotide transport (GO:0051503)4.42615833
26mannose metabolic process (GO:0006013)4.40237842
27urinary tract smooth muscle contraction (GO:0014848)4.34653363
28regulation of interferon-beta biosynthetic process (GO:0045357)4.32040688
29purine ribonucleotide transport (GO:0015868)4.31533128
30purinergic receptor signaling pathway (GO:0035587)4.30149365
31dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.11693770
32positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.08956710
33melanin biosynthetic process (GO:0042438)4.04000194
34estrogen biosynthetic process (GO:0006703)4.03480818
35regulation of phospholipid biosynthetic process (GO:0071071)4.01243754
36sulfur amino acid catabolic process (GO:0000098)3.99408745
37positive regulation of systemic arterial blood pressure (GO:0003084)3.95366661
38endocytic recycling (GO:0032456)3.94780882
39DNA replication checkpoint (GO:0000076)3.93097738
40UV protection (GO:0009650)3.90651450
41transepithelial transport (GO:0070633)3.88491968
42negative regulation of interleukin-8 production (GO:0032717)3.88336323
43negative regulation of response to biotic stimulus (GO:0002832)3.85222645
44histone phosphorylation (GO:0016572)3.79309353
45mitochondrial genome maintenance (GO:0000002)3.77533843
46granulocyte differentiation (GO:0030851)3.77165212
47grooming behavior (GO:0007625)3.74634516
48positive regulation of heat generation (GO:0031652)3.73978077
49detection of light stimulus involved in sensory perception (GO:0050962)3.73751551
50detection of light stimulus involved in visual perception (GO:0050908)3.73751551
51peristalsis (GO:0030432)3.71979959
52melanin metabolic process (GO:0006582)3.71622852
53G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.67271929
54regulation of protein kinase A signaling (GO:0010738)3.65821208
55glutathione biosynthetic process (GO:0006750)3.57266721
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.56740432
57cornea development in camera-type eye (GO:0061303)3.50810799
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46252020
59folic acid metabolic process (GO:0046655)3.43174471
60protein import into peroxisome matrix (GO:0016558)3.42935916
61nucleoside transmembrane transport (GO:1901642)3.41944806
62keratinocyte development (GO:0003334)3.41914317
63positive regulation of odontogenesis (GO:0042482)3.33513602
64sex determination (GO:0007530)3.33060775
65sphingomyelin metabolic process (GO:0006684)3.32569156
66purine nucleotide transport (GO:0015865)3.29689693
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.20409167
68nonribosomal peptide biosynthetic process (GO:0019184)3.17411026
69phosphorylated carbohydrate dephosphorylation (GO:0046838)3.11589395
70inositol phosphate dephosphorylation (GO:0046855)3.11589395
71regulation of cell aging (GO:0090342)3.10627706
72phosphatidylglycerol biosynthetic process (GO:0006655)3.06817333
73protein insertion into membrane (GO:0051205)3.05624706
74cellular anion homeostasis (GO:0030002)3.03494419
75secondary metabolite biosynthetic process (GO:0044550)3.02258919
76positive regulation of blood pressure (GO:0045777)2.98522222
77sialylation (GO:0097503)2.95348021
78phosphate ion homeostasis (GO:0055062)2.90103728
79trivalent inorganic anion homeostasis (GO:0072506)2.90103728
80proline biosynthetic process (GO:0006561)2.87783329
81negative regulation of actin filament bundle assembly (GO:0032232)2.86991270
82sphingosine metabolic process (GO:0006670)2.83152471
83regulation of urine volume (GO:0035809)2.82785319
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80011843
85regulation of glycogen (starch) synthase activity (GO:2000465)2.79130561
86glycine transport (GO:0015816)2.78934650
87gonadal mesoderm development (GO:0007506)2.78554034
88tRNA modification (GO:0006400)2.78250628
89phosphate ion transmembrane transport (GO:0035435)2.69730718
90diol metabolic process (GO:0034311)2.68791613
91purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67136967
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67136967
93motile cilium assembly (GO:0044458)2.67053085
94behavioral response to nicotine (GO:0035095)2.65817237
95folic acid transport (GO:0015884)2.65565859
96negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.65029698
97cilium or flagellum-dependent cell motility (GO:0001539)2.63073294
98keratan sulfate metabolic process (GO:0042339)2.62665109
99regulation of heat generation (GO:0031650)2.62032242
100GDP-mannose metabolic process (GO:0019673)10.4733476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.70321291
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.22036498
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.54890787
4* LXR_22292898_ChIP-Seq_THP-1_Human2.99917437
5P68_20966046_ChIP-Seq_HELA_Human2.90681978
6XRN2_22483619_ChIP-Seq_HELA_Human2.63559833
7VDR_24763502_ChIP-Seq_THP-1_Human2.59111787
8* MAF_26560356_Chip-Seq_TH2_Human2.50348750
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42899872
10MAF_26560356_Chip-Seq_TH1_Human2.40777375
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28176461
12BCOR_27268052_Chip-Seq_Bcells_Human2.21565375
13* RACK7_27058665_Chip-Seq_MCF-7_Human2.19605624
14E2F1_20622854_ChIP-Seq_HELA_Human2.19511077
15BCL6_27268052_Chip-Seq_Bcells_Human2.15631216
16* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.14799489
17* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.11876040
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.10949823
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.10541882
20CTCF_27219007_Chip-Seq_Bcells_Human2.05730687
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98563556
22* UTX_26944678_Chip-Seq_JUKART_Human1.97771604
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96809958
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96113288
25PHF8_20622854_ChIP-Seq_HELA_Human1.94806457
26RARB_24833708_ChIP-Seq_LIVER_Mouse1.93801357
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91115949
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.90666884
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86240899
30KDM2B_26808549_Chip-Seq_DND41_Human1.82953397
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82921265
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.82108231
33MYC_22102868_ChIP-Seq_BL_Human1.80317468
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.72957270
35SMC4_20622854_ChIP-Seq_HELA_Human1.72781100
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72628376
37RXRA_24833708_ChIP-Seq_LIVER_Mouse1.69851824
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.69606721
39RARA_24833708_ChIP-Seq_LIVER_Mouse1.67116885
40SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66767394
41* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.64953046
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63868106
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.63122668
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61741296
45CTCF_21964334_Chip-Seq_Bcells_Human1.59558908
46TCF7_22412390_ChIP-Seq_EML_Mouse1.55329746
47FOXP1_21924763_ChIP-Seq_HESCs_Human1.54428457
48SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52344246
49CTCF_21964334_ChIP-Seq_BJAB-B_Human1.51284829
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50248769
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48800598
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.47066604
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.44362493
54TP53_22127205_ChIP-Seq_IMR90_Human1.39412316
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.38952613
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37474731
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35927238
58CTCF_20526341_ChIP-Seq_ESCs_Human1.35252492
59SA1_27219007_Chip-Seq_Bcells_Human1.34971045
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33973961
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27959148
62* CIITA_25753668_ChIP-Seq_RAJI_Human1.26704361
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25069536
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24398198
65ERA_21632823_ChIP-Seq_H3396_Human1.22274773
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22029103
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21943981
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19864046
69ETS1_21867929_ChIP-Seq_TH2_Mouse1.19446868
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19342107
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19123560
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19095763
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18557508
74FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18554526
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17902139
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.15194114
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14214254
78NCOR1_26117541_ChIP-Seq_K562_Human1.14056346
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12890952
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.11838367
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11817208
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.11437563
83* ATF3_27146783_Chip-Seq_COLON_Human1.10287481
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08770519
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08365074
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05954591
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05030904
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.03970919
89NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.03396282
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03051768
91P300_27268052_Chip-Seq_Bcells_Human1.03030604
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02747931
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02137770
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01233437
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96417000
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96181643
97SPI1_20517297_ChIP-Seq_HL60_Human0.95844749
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95569716
99* KDM2B_26808549_Chip-Seq_K562_Human0.94902206
100OCT4_20526341_ChIP-Seq_ESCs_Human0.94860834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.30182431
2MP0001986_abnormal_taste_sensitivity5.93593573
3MP0005423_abnormal_somatic_nervous5.69828947
4MP0005174_abnormal_tail_pigmentation5.59529509
5MP0003136_yellow_coat_color4.78986232
6MP0005409_darkened_coat_color3.20736067
7MP0005083_abnormal_biliary_tract3.06834411
8MP0004381_abnormal_hair_follicle2.98225395
9MP0001188_hyperpigmentation2.70925751
10MP0001968_abnormal_touch/_nociception2.66012785
11MP0001756_abnormal_urination2.12112493
12MP0004130_abnormal_muscle_cell2.09641753
13MP0000015_abnormal_ear_pigmentation2.02157098
14MP0002736_abnormal_nociception_after1.89765738
15MP0001661_extended_life_span1.88617525
16MP0008875_abnormal_xenobiotic_pharmacok1.85628249
17MP0000751_myopathy1.81579312
18MP0003705_abnormal_hypodermis_morpholog1.78234685
19MP0003453_abnormal_keratinocyte_physiol1.76064459
20MP0001502_abnormal_circadian_rhythm1.66981554
21MP0003111_abnormal_nucleus_morphology1.59259323
22MP0000538_abnormal_urinary_bladder1.57888683
23MP0005330_cardiomyopathy1.54996622
24MP0005257_abnormal_intraocular_pressure1.54117599
25MP0001348_abnormal_lacrimal_gland1.53539079
26MP0002160_abnormal_reproductive_system1.50642074
27MP0005076_abnormal_cell_differentiation1.47124161
28MP0000750_abnormal_muscle_regeneration1.45790630
29MP0003303_peritoneal_inflammation1.44767592
30MP0002909_abnormal_adrenal_gland1.41420808
31MP0002638_abnormal_pupillary_reflex1.35892918
32MP0003878_abnormal_ear_physiology1.29411510
33MP0005377_hearing/vestibular/ear_phenot1.29411510
34MP0005058_abnormal_lysosome_morphology1.20481741
35MP0003011_delayed_dark_adaptation1.19839595
36MP0003448_altered_tumor_morphology1.17396280
37MP0009840_abnormal_foam_cell1.12016128
38MP0005410_abnormal_fertilization1.11470726
39MP0003693_abnormal_embryo_hatching1.08551326
40MP0003137_abnormal_impulse_conducting1.08525663
41MP0005332_abnormal_amino_acid1.07735373
42MP0009278_abnormal_bone_marrow1.05401671
43MP0005084_abnormal_gallbladder_morpholo1.05346390
44MP0001765_abnormal_ion_homeostasis1.05213403
45MP0009333_abnormal_splenocyte_physiolog1.02489641
46MP0005501_abnormal_skin_physiology1.01314003
47MP0001919_abnormal_reproductive_system1.00320546
48MP0002735_abnormal_chemical_nociception0.99346347
49MP0005551_abnormal_eye_electrophysiolog0.98325372
50MP0005584_abnormal_enzyme/coenzyme_acti0.96593863
51MP0001664_abnormal_digestion0.95323671
52MP0004043_abnormal_pH_regulation0.95004670
53MP0005220_abnormal_exocrine_pancreas0.93939141
54MP0000003_abnormal_adipose_tissue0.90358899
55MP0000013_abnormal_adipose_tissue0.89997634
56MP0000470_abnormal_stomach_morphology0.89814211
57MP0000367_abnormal_coat/_hair0.84790056
58MP0002075_abnormal_coat/hair_pigmentati0.83217783
59MP0003183_abnormal_peptide_metabolism0.80741565
60MP0003806_abnormal_nucleotide_metabolis0.79151007
61MP0009931_abnormal_skin_appearance0.78749555
62MP0003077_abnormal_cell_cycle0.78687873
63MP0004185_abnormal_adipocyte_glucose0.78627912
64MP0002928_abnormal_bile_duct0.78257764
65MP0001905_abnormal_dopamine_level0.78068656
66MP0001958_emphysema0.76406378
67MP0004019_abnormal_vitamin_homeostasis0.74555597
68MP0001324_abnormal_eye_pigmentation0.71383911
69MP0004957_abnormal_blastocyst_morpholog0.70563308
70MP0000371_diluted_coat_color0.70451283
71MP0000747_muscle_weakness0.67358147
72MP0003091_abnormal_cell_migration0.66918882
73MP0002136_abnormal_kidney_physiology0.66881619
74MP0002019_abnormal_tumor_incidence0.66482969
75MP0001849_ear_inflammation0.63203752
76MP0009643_abnormal_urine_homeostasis0.61806219
77MP0010771_integument_phenotype0.60614596
78MP0005253_abnormal_eye_physiology0.60500451
79MP0004947_skin_inflammation0.57889517
80MP0002723_abnormal_immune_serum0.57806200
81MP0005365_abnormal_bile_salt0.55722002
82MP0005389_reproductive_system_phenotype0.55566135
83MP0001346_abnormal_lacrimal_gland0.54623516
84MP0005025_abnormal_response_to0.54546660
85MP0002933_joint_inflammation0.53716320
86MP0001873_stomach_inflammation0.53017804
87MP0002398_abnormal_bone_marrow0.52331402
88MP0002148_abnormal_hypersensitivity_rea0.51503532
89MP0001800_abnormal_humoral_immune0.51278938
90MP0000678_abnormal_parathyroid_gland0.51167738
91MP0001191_abnormal_skin_condition0.50728994
92MP0001835_abnormal_antigen_presentation0.49914151
93MP0002429_abnormal_blood_cell0.49657922
94MP0002452_abnormal_antigen_presenting0.47372016
95MP0005647_abnormal_sex_gland0.46661352
96MP0001186_pigmentation_phenotype0.46534904
97MP0002420_abnormal_adaptive_immunity0.44985820
98MP0010094_abnormal_chromosome_stability0.44646056
99MP0003045_fibrosis0.44040097
100MP0003879_abnormal_hair_cell0.43717122

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.28889289
2Rectal fistula (HP:0100590)6.01884955
3Rectovaginal fistula (HP:0000143)6.01884955
4Rib fusion (HP:0000902)5.87239121
5Intestinal fistula (HP:0100819)5.71166705
6Vaginal fistula (HP:0004320)5.50345596
7Poikiloderma (HP:0001029)4.94089962
8Attenuation of retinal blood vessels (HP:0007843)4.64279999
9Thin bony cortex (HP:0002753)4.51649551
10Congenital stationary night blindness (HP:0007642)4.46309536
11Ulnar bowing (HP:0003031)4.34946303
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.27577580
13Dyschromatopsia (HP:0007641)4.26859765
14Akinesia (HP:0002304)4.20492236
15Popliteal pterygium (HP:0009756)4.09878399
16Abnormality of the intrinsic pathway (HP:0010989)4.09177557
17Annular pancreas (HP:0001734)4.04029105
18Facial diplegia (HP:0001349)3.81369325
19Facial hemangioma (HP:0000329)3.77314347
20Chorioretinal atrophy (HP:0000533)3.63374075
21Squamous cell carcinoma (HP:0002860)3.57216665
22Aplasia of the musculature (HP:0100854)3.54167051
23Mesangial abnormality (HP:0001966)3.52998672
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.52507270
25Joint hemorrhage (HP:0005261)3.50404994
26Turricephaly (HP:0000262)3.50212101
27Prolonged partial thromboplastin time (HP:0003645)3.49564346
28Fetal akinesia sequence (HP:0001989)3.44112547
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42310782
30Abnormal albumin level (HP:0012116)3.38953406
31Hypoalbuminemia (HP:0003073)3.38953406
32Premature graying of hair (HP:0002216)3.34094564
33Atrioventricular block (HP:0001678)3.33745195
34Short chin (HP:0000331)3.30993539
35Delayed epiphyseal ossification (HP:0002663)3.28061418
36Anteriorly placed anus (HP:0001545)3.21502985
37Hemorrhage of the eye (HP:0011885)3.16594283
38Coronal craniosynostosis (HP:0004440)3.13461367
39Choroideremia (HP:0001139)3.03223517
40Bony spicule pigmentary retinopathy (HP:0007737)2.94173592
41Abnormality of placental membranes (HP:0011409)2.91669684
42Amniotic constriction ring (HP:0009775)2.91669684
43Fused cervical vertebrae (HP:0002949)2.89712507
44Patellar aplasia (HP:0006443)2.87822211
45Decreased central vision (HP:0007663)2.84068036
46Abnormality of the costochondral junction (HP:0000919)2.81967575
47Aplasia/Hypoplasia of the patella (HP:0006498)2.68099421
48Increased hepatocellular lipid droplets (HP:0006565)2.67550083
49Renal Fanconi syndrome (HP:0001994)2.67041672
50Birth length less than 3rd percentile (HP:0003561)2.61380987
51Abnormality of the pons (HP:0007361)2.59941719
52Enlarged epiphyses (HP:0010580)2.52734744
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.51074141
54Hypoplasia of the pons (HP:0012110)2.50753342
55Joint stiffness (HP:0001387)2.46585222
56Lipid accumulation in hepatocytes (HP:0006561)2.45063563
57Bowed forearm bones (HP:0003956)2.42869045
58Bowing of the arm (HP:0006488)2.42869045
59Myotonia (HP:0002486)2.39844627
60Myopathic facies (HP:0002058)2.37840005
61Absent thumb (HP:0009777)2.35792746
62Widely patent fontanelles and sutures (HP:0004492)2.32425694
63Pustule (HP:0200039)2.32081096
64Zonular cataract (HP:0010920)2.29726931
65Reduced antithrombin III activity (HP:0001976)2.22893926
66Flat occiput (HP:0005469)2.22731499
67Unilateral renal agenesis (HP:0000122)2.13842190
68Cheilitis (HP:0100825)2.09316041
69Increased number of teeth (HP:0011069)2.09007192
70Abnormal epiphyseal ossification (HP:0010656)2.08658943
71Gastrointestinal infarctions (HP:0005244)2.04541227
72Basal cell carcinoma (HP:0002671)2.04066855
73Choanal stenosis (HP:0000452)2.03081194
74Short thumb (HP:0009778)2.02267404
75Thrombocytosis (HP:0001894)2.02126790
76Hypophosphatemic rickets (HP:0004912)2.01646797
77Short humerus (HP:0005792)2.00654198
78Capillary hemangiomas (HP:0005306)1.97519551
79Neonatal onset (HP:0003623)1.96169621
80Progressive external ophthalmoplegia (HP:0000590)1.96109439
81Exertional dyspnea (HP:0002875)1.94347524
82Increased intramyocellular lipid droplets (HP:0012240)1.93505626
83Male infertility (HP:0003251)1.92372902
84Narrow nasal bridge (HP:0000446)1.91234706
85Thin ribs (HP:0000883)1.89606428
86Villous atrophy (HP:0011473)1.88365459
87Abnormality of small intestinal villus morphology (HP:0011472)1.88365459
88Heart block (HP:0012722)1.85466738
89Absent radius (HP:0003974)1.85160803
90Decreased circulating renin level (HP:0003351)1.84980370
91Increased muscle lipid content (HP:0009058)1.84748303
92Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84726467
93Abnormality of polysaccharide metabolism (HP:0011012)1.84726467
94Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84726467
95Abnormality of the common coagulation pathway (HP:0010990)1.83886090
96Abnormal trabecular bone morphology (HP:0100671)1.83038321
97Mucopolysacchariduria (HP:0008155)1.81844947
98Urinary glycosaminoglycan excretion (HP:0003541)1.81844947
99Diminished movement (HP:0002374)1.80752172
100Neonatal respiratory distress (HP:0002643)1.80313604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.95314242
2BLK4.91947925
3TLK14.42923741
4WNK43.74065524
5TESK23.24240985
6GRK62.82710857
7SIK22.81342539
8PDK22.65805558
9MUSK2.58099383
10ZAK2.54294437
11STK162.50065316
12ADRBK22.11464686
13TAOK32.01810049
14TRIB31.76810507
15MAP4K11.74857386
16SIK11.73969524
17ZAP701.60752298
18GRK71.60362278
19TBK11.49305216
20IRAK21.43977812
21SMG11.39106286
22IKBKE1.34627258
23IRAK41.31884798
24CCNB11.25139237
25MAPK121.23928762
26ERN11.22764242
27NEK21.22302772
28MAP2K31.18157025
29MAP2K41.15225591
30WNK11.04349057
31PDPK11.03861507
32SYK1.02761818
33ADRBK11.02173652
34HIPK21.01270046
35KDR1.00551869
36RPS6KA60.93190421
37IKBKB0.93122850
38CSK0.90623465
39CDK40.89216370
40PIM10.86955999
41PRKD20.85457644
42RPS6KC10.84332435
43RPS6KL10.84332435
44STK390.79263549
45AURKA0.77044262
46MST1R0.74769833
47RIPK40.73362936
48STK110.73355696
49LYN0.73090915
50PRKD10.72473386
51FES0.70091874
52PIM20.70071035
53MAPK110.69286835
54EEF2K0.67048181
55STK40.64673027
56RPS6KA20.61995932
57MAP2K60.61592437
58MAP3K20.61331090
59SIK30.61241020
60RPS6KA50.54069580
61DYRK1B0.51851133
62GRK50.50298947
63MAP3K140.50033883
64JAK30.49674491
65DAPK20.49483077
66CDK150.48509341
67SGK4940.48454470
68SGK2230.48454470
69BTK0.46237042
70ACVR1B0.45770620
71PDK10.44206421
72CDK180.43014038
73CDK60.40632208
74CDK11A0.39197069
75DAPK30.38909517
76JAK20.37512290
77PAK10.36758972
78CSF1R0.33816109
79PRPF4B0.33091358
80KSR20.32380562
81CHEK20.32353938
82ATR0.30226317
83MAPK70.28591085
84MELK0.28168931
85PDGFRB0.27497962
86CHUK0.27037675
87VRK10.26305876
88MAPK80.23730357
89RAF10.23543808
90TGFBR20.22663414
91BMX0.21433732
92AKT20.20861443
93STK100.20793718
94SGK30.20527673
95MAP2K10.20009468
96CDK80.18541851
97MAPKAPK30.17197494
98PRKG20.16391089
99CDK140.16323553
100TNK20.15225817

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.46895014
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.65563864
3Sulfur relay system_Homo sapiens_hsa041224.79474712
4Fructose and mannose metabolism_Homo sapiens_hsa000513.55831971
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.44560796
6Glycosaminoglycan degradation_Homo sapiens_hsa005313.16435572
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.65147076
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02084196
9Systemic lupus erythematosus_Homo sapiens_hsa053221.79105591
10Sphingolipid metabolism_Homo sapiens_hsa006001.55074750
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.52923798
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46111764
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43728412
14Hedgehog signaling pathway_Homo sapiens_hsa043401.41649885
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39889413
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35994893
17Ovarian steroidogenesis_Homo sapiens_hsa049131.33740076
18Fanconi anemia pathway_Homo sapiens_hsa034601.28483672
19Alcoholism_Homo sapiens_hsa050341.19519531
20Taste transduction_Homo sapiens_hsa047421.14070738
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12963504
22mTOR signaling pathway_Homo sapiens_hsa041501.12809133
23Inositol phosphate metabolism_Homo sapiens_hsa005621.12372804
24Bladder cancer_Homo sapiens_hsa052191.10595075
25Hematopoietic cell lineage_Homo sapiens_hsa046401.10544550
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09964064
27Vitamin digestion and absorption_Homo sapiens_hsa049771.07868898
28Circadian rhythm_Homo sapiens_hsa047100.93833516
29Lysosome_Homo sapiens_hsa041420.90906018
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86179649
31Maturity onset diabetes of the young_Homo sapiens_hsa049500.84010267
32Nitrogen metabolism_Homo sapiens_hsa009100.83728216
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81485245
34Intestinal immune network for IgA production_Homo sapiens_hsa046720.81270546
35Other glycan degradation_Homo sapiens_hsa005110.81198981
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79010393
37N-Glycan biosynthesis_Homo sapiens_hsa005100.78872449
38Calcium signaling pathway_Homo sapiens_hsa040200.68692831
39Phototransduction_Homo sapiens_hsa047440.64625355
40Leishmaniasis_Homo sapiens_hsa051400.62234157
41VEGF signaling pathway_Homo sapiens_hsa043700.61084779
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60574127
43Tuberculosis_Homo sapiens_hsa051520.57634355
44Melanogenesis_Homo sapiens_hsa049160.57180460
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56303152
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56097262
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.56078649
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54850963
49Primary immunodeficiency_Homo sapiens_hsa053400.54705654
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52752139
51Non-small cell lung cancer_Homo sapiens_hsa052230.51905403
52Endocytosis_Homo sapiens_hsa041440.51046480
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50297093
54Osteoclast differentiation_Homo sapiens_hsa043800.49739473
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47053301
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.43864061
57Insulin resistance_Homo sapiens_hsa049310.42622665
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.40585788
59RNA polymerase_Homo sapiens_hsa030200.40128973
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39804956
61Cocaine addiction_Homo sapiens_hsa050300.39758344
62Influenza A_Homo sapiens_hsa051640.38428750
63Toxoplasmosis_Homo sapiens_hsa051450.38424539
64B cell receptor signaling pathway_Homo sapiens_hsa046620.37705850
65Platelet activation_Homo sapiens_hsa046110.36619820
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35388890
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35193579
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34717949
69Bile secretion_Homo sapiens_hsa049760.34480411
70Gap junction_Homo sapiens_hsa045400.33629441
71Apoptosis_Homo sapiens_hsa042100.33175559
72HTLV-I infection_Homo sapiens_hsa051660.32457010
73Hippo signaling pathway_Homo sapiens_hsa043900.32368131
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32063717
75Staphylococcus aureus infection_Homo sapiens_hsa051500.31716934
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31558027
77Viral carcinogenesis_Homo sapiens_hsa052030.29579155
78Measles_Homo sapiens_hsa051620.28296871
79Hepatitis C_Homo sapiens_hsa051600.27584068
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.26662798
81Basal cell carcinoma_Homo sapiens_hsa052170.26102827
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.25635111
83Base excision repair_Homo sapiens_hsa034100.25489406
84Pyrimidine metabolism_Homo sapiens_hsa002400.25453896
85Biosynthesis of amino acids_Homo sapiens_hsa012300.25262694
86Basal transcription factors_Homo sapiens_hsa030220.25073653
87Nicotine addiction_Homo sapiens_hsa050330.24960703
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23998144
89MAPK signaling pathway_Homo sapiens_hsa040100.22913707
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22102054
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21055928
92Chemokine signaling pathway_Homo sapiens_hsa040620.19602853
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18236025
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17874368
95TGF-beta signaling pathway_Homo sapiens_hsa043500.16587125
96TNF signaling pathway_Homo sapiens_hsa046680.15442037
97Sulfur metabolism_Homo sapiens_hsa009200.15057436
98Cholinergic synapse_Homo sapiens_hsa047250.14891063
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14387356
100Graft-versus-host disease_Homo sapiens_hsa053320.12608194

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