PRR13P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.87875391
2cytidine metabolic process (GO:0046087)4.62148322
3cytidine catabolic process (GO:0006216)4.62148322
4cytidine deamination (GO:0009972)4.62148322
5regulation of T cell tolerance induction (GO:0002664)4.38662637
6immunoglobulin mediated immune response (GO:0016064)4.36664843
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33850491
8ATP synthesis coupled proton transport (GO:0015986)3.90596152
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90596152
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.85662795
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83905706
12regulation of tolerance induction (GO:0002643)3.80711650
13positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79575345
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.77208325
15B cell mediated immunity (GO:0019724)3.68170759
16regulation of isotype switching to IgG isotypes (GO:0048302)3.67985602
17regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.61391726
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56348589
19regulation of regulatory T cell differentiation (GO:0045589)3.53390101
20respiratory electron transport chain (GO:0022904)3.47164171
21positive regulation of gamma-delta T cell activation (GO:0046645)3.45168550
22electron transport chain (GO:0022900)3.43124984
23positive thymic T cell selection (GO:0045059)3.41835371
24cytochrome complex assembly (GO:0017004)3.40914405
25actin nucleation (GO:0045010)3.38236812
26respiratory chain complex IV assembly (GO:0008535)3.34259593
27metallo-sulfur cluster assembly (GO:0031163)3.25955058
28iron-sulfur cluster assembly (GO:0016226)3.25955058
29T cell migration (GO:0072678)3.23130201
30positive regulation of prostaglandin secretion (GO:0032308)3.16553287
31protein-cofactor linkage (GO:0018065)3.13250325
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11746393
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11551238
34protein complex biogenesis (GO:0070271)3.10027472
35regulation of B cell receptor signaling pathway (GO:0050855)3.04071307
36positive T cell selection (GO:0043368)2.98946616
37regulation of chronic inflammatory response (GO:0002676)2.98472101
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97890736
39kinetochore assembly (GO:0051382)2.94811886
40positive regulation of B cell differentiation (GO:0045579)2.94790817
41innate immune response in mucosa (GO:0002227)2.91613423
42negative regulation of B cell apoptotic process (GO:0002903)2.90298500
43lymphocyte costimulation (GO:0031294)2.88654028
44positive regulation of DNA recombination (GO:0045911)2.87344378
45positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86930881
46proteasome assembly (GO:0043248)2.86879894
47hydrogen ion transmembrane transport (GO:1902600)2.85940135
48T cell costimulation (GO:0031295)2.85660416
49pseudouridine synthesis (GO:0001522)2.84601702
50mitochondrial respiratory chain complex assembly (GO:0033108)2.84369858
51positive regulation of interleukin-17 production (GO:0032740)2.83052002
52mast cell activation (GO:0045576)2.82599628
53positive regulation of B cell mediated immunity (GO:0002714)2.82059418
54positive regulation of immunoglobulin mediated immune response (GO:0002891)2.82059418
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81868851
56regulation of alpha-beta T cell proliferation (GO:0046640)2.81575961
57transcription elongation from RNA polymerase III promoter (GO:0006385)2.81473185
58termination of RNA polymerase III transcription (GO:0006386)2.81473185
59positive regulation of isotype switching (GO:0045830)2.81067388
60cellular response to interleukin-15 (GO:0071350)2.80732427
61positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80486102
62negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.79432859
63regulation of immunoglobulin secretion (GO:0051023)2.75688272
64negative regulation of viral genome replication (GO:0045071)2.75554623
65ribosomal small subunit assembly (GO:0000028)2.74103227
66regulation of cellular amino acid metabolic process (GO:0006521)2.73507459
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71570888
68valine metabolic process (GO:0006573)2.70755090
69regulation of T cell receptor signaling pathway (GO:0050856)2.70181868
70negative regulation of lymphocyte apoptotic process (GO:0070229)2.69677568
71positive regulation of interleukin-12 production (GO:0032735)2.69147781
72regulation of gamma-delta T cell activation (GO:0046643)2.67814196
73negative regulation of T cell apoptotic process (GO:0070233)2.66027120
74base-excision repair, AP site formation (GO:0006285)2.65432411
75regulation of gamma-delta T cell differentiation (GO:0045586)2.64641628
76proton transport (GO:0015992)2.63856453
77positive regulation of fatty acid transport (GO:2000193)2.63329693
78positive regulation of interferon-gamma production (GO:0032729)2.62243774
79positive regulation of tolerance induction (GO:0002645)2.60986679
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60339481
81hydrogen transport (GO:0006818)2.58279865
82positive regulation of interleukin-8 secretion (GO:2000484)2.58104289
83positive regulation of humoral immune response (GO:0002922)2.57371023
84regulation of interleukin-2 biosynthetic process (GO:0045076)2.56623022
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.55697401
86regulation of T cell mediated cytotoxicity (GO:0001914)2.55235213
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52887223
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52231850
89regulation of mitochondrial translation (GO:0070129)2.52225990
90cytokine biosynthetic process (GO:0042089)2.52161746
91positive regulation of natural killer cell differentiation (GO:0032825)2.51540085
92GTP biosynthetic process (GO:0006183)2.51211332
93negative T cell selection (GO:0043383)2.48544038
94interferon-gamma-mediated signaling pathway (GO:0060333)2.48476126
95mucosal immune response (GO:0002385)2.47623039
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46367068
97regulation of interleukin-6 biosynthetic process (GO:0045408)2.44913611
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44870970
99negative regulation of T cell receptor signaling pathway (GO:0050860)2.44661078
100mast cell activation involved in immune response (GO:0002279)2.44434308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.51937138
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.32809157
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38066902
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.16300438
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93569727
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91379504
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86896322
8VDR_23849224_ChIP-Seq_CD4+_Human2.60810384
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51441301
10IGF1R_20145208_ChIP-Seq_DFB_Human2.43178510
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39030850
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35034938
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.30723483
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29180034
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21927017
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21605577
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16257007
18VDR_22108803_ChIP-Seq_LS180_Human2.11417902
19MYB_26560356_Chip-Seq_TH2_Human2.06574026
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04994397
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.91488826
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.88528247
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87473017
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84543486
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80984581
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80421210
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.65889536
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57706911
29ELK1_19687146_ChIP-ChIP_HELA_Human1.56864859
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56421600
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.54526546
32FOXP3_21729870_ChIP-Seq_TREG_Human1.54042905
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50946736
34MYC_18940864_ChIP-ChIP_HL60_Human1.50759068
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49447750
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47840961
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39755358
38GATA3_27048872_Chip-Seq_THYMUS_Human1.39227858
39GATA3_26560356_Chip-Seq_TH2_Human1.39082561
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36180283
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.35541732
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33956990
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33377413
44NCOR_22424771_ChIP-Seq_293T_Human1.31387662
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.27926602
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27926602
47SPI1_23547873_ChIP-Seq_NB4_Human1.26589069
48PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26555490
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.24221489
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21880507
51STAT1_20625510_ChIP-Seq_HELA_Human1.21782645
52ERA_21632823_ChIP-Seq_H3396_Human1.21693245
53RUNX_20019798_ChIP-Seq_JUKART_Human1.20802911
54MYB_26560356_Chip-Seq_TH1_Human1.19268648
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19151160
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18797996
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18042133
58IRF1_19129219_ChIP-ChIP_H3396_Human1.17688006
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15374137
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.13532836
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12392422
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11258381
63P300_27268052_Chip-Seq_Bcells_Human1.10377583
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08943403
65TP53_22573176_ChIP-Seq_HFKS_Human1.05518108
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04880276
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04413425
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00751728
69CTCF_20526341_ChIP-Seq_ESCs_Human1.00500029
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00231722
71HOXB7_26014856_ChIP-Seq_BT474_Human0.99927036
72MAF_26560356_Chip-Seq_TH2_Human0.98661826
73AR_20517297_ChIP-Seq_VCAP_Human0.98275765
74P53_21459846_ChIP-Seq_SAOS-2_Human0.97983997
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97696838
76TAF2_19829295_ChIP-Seq_ESCs_Human0.96708269
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96437682
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96421373
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.96230771
80TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94450333
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94337482
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.94066026
83MAF_26560356_Chip-Seq_TH1_Human0.92872119
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92424198
85UTX_26944678_Chip-Seq_JUKART_Human0.92163765
86NANOG_20526341_ChIP-Seq_ESCs_Human0.92100111
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91989657
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91169733
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91146132
90HTT_18923047_ChIP-ChIP_STHdh_Human0.90383611
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88626649
92SOX2_19829295_ChIP-Seq_ESCs_Human0.87621364
93NANOG_19829295_ChIP-Seq_ESCs_Human0.87621364
94SMRT_27268052_Chip-Seq_Bcells_Human0.86657131
95MYC_19829295_ChIP-Seq_ESCs_Human0.85410972
96ERG_20517297_ChIP-Seq_VCAP_Human0.83828288
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83400780
98TTF2_22483619_ChIP-Seq_HELA_Human0.82731105
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81567318
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81192649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.91722082
2MP0000685_abnormal_immune_system4.01636231
3MP0001835_abnormal_antigen_presentation3.86357193
4MP0005645_abnormal_hypothalamus_physiol3.40320927
5MP0002138_abnormal_hepatobiliary_system2.89100589
6MP0002148_abnormal_hypersensitivity_rea2.68685028
7MP0005387_immune_system_phenotype2.59946921
8MP0001790_abnormal_immune_system2.59946921
9MP0009785_altered_susceptibility_to2.58670161
10MP0001800_abnormal_humoral_immune2.43687139
11MP0001873_stomach_inflammation2.24830187
12MP0002102_abnormal_ear_morphology2.24235701
13MP0001853_heart_inflammation2.12685182
14MP0006292_abnormal_olfactory_placode2.08277527
15MP0005000_abnormal_immune_tolerance2.07144610
16MP0008875_abnormal_xenobiotic_pharmacok2.06319064
17MP0009333_abnormal_splenocyte_physiolog2.06145898
18MP0009379_abnormal_foot_pigmentation2.03492001
19MP0002723_abnormal_immune_serum1.97176443
20MP0002837_dystrophic_cardiac_calcinosis1.96534399
21MP0005025_abnormal_response_to1.92267553
22MP0001881_abnormal_mammary_gland1.85349353
23MP0003763_abnormal_thymus_physiology1.82964367
24MP0002420_abnormal_adaptive_immunity1.79676498
25MP0002452_abnormal_antigen_presenting1.77420924
26MP0003011_delayed_dark_adaptation1.77263161
27MP0001819_abnormal_immune_cell1.76529838
28MP0010386_abnormal_urinary_bladder1.75191684
29MP0002277_abnormal_respiratory_mucosa1.74781050
30MP0002876_abnormal_thyroid_physiology1.71660827
31MP0002254_reproductive_system_inflammat1.69652097
32MP0002163_abnormal_gland_morphology1.68950145
33MP0009046_muscle_twitch1.59868186
34MP0000372_irregular_coat_pigmentation1.57783955
35MP0003806_abnormal_nucleotide_metabolis1.56814163
36MP0003866_abnormal_defecation1.53785590
37MP0000716_abnormal_immune_system1.48578772
38MP0003195_calcinosis1.48182554
39MP0002398_abnormal_bone_marrow1.43963744
40MP0008872_abnormal_physiological_respon1.43172601
41MP0004147_increased_porphyrin_level1.37935091
42MP0004510_myositis1.34261888
43MP0006082_CNS_inflammation1.34137443
44MP0000689_abnormal_spleen_morphology1.31847587
45MP0005084_abnormal_gallbladder_morpholo1.27161086
46MP0001905_abnormal_dopamine_level1.26852067
47MP0010155_abnormal_intestine_physiology1.21726434
48MP0002405_respiratory_system_inflammati1.21238447
49MP0002429_abnormal_blood_cell1.20105201
50MP0002166_altered_tumor_susceptibility1.19548367
51MP0001845_abnormal_inflammatory_respons1.19213541
52MP0004145_abnormal_muscle_electrophysio1.19205393
53MP0002722_abnormal_immune_system1.18569493
54MP0002419_abnormal_innate_immunity1.12380512
55MP0008469_abnormal_protein_level1.11297688
56MP0006036_abnormal_mitochondrial_physio1.11082386
57MP0005174_abnormal_tail_pigmentation1.10552666
58MP0002160_abnormal_reproductive_system1.09658541
59MP0005636_abnormal_mineral_homeostasis1.09426168
60MP0003646_muscle_fatigue1.05359552
61MP0004019_abnormal_vitamin_homeostasis1.04558905
62MP0000465_gastrointestinal_hemorrhage1.02421792
63MP0005310_abnormal_salivary_gland1.01521589
64MP0005379_endocrine/exocrine_gland_phen1.01414776
65MP0000703_abnormal_thymus_morphology0.99754297
66MP0002693_abnormal_pancreas_physiology0.96994962
67MP0005389_reproductive_system_phenotype0.92806022
68MP0005646_abnormal_pituitary_gland0.91652325
69MP0002735_abnormal_chemical_nociception0.91343266
70MP0002928_abnormal_bile_duct0.91285670
71MP0002272_abnormal_nervous_system0.87642366
72MP0002006_tumorigenesis0.86119575
73MP0008058_abnormal_DNA_repair0.85375874
74MP0005551_abnormal_eye_electrophysiolog0.84911814
75MP0003879_abnormal_hair_cell0.83879558
76MP0000604_amyloidosis0.81060824
77MP0009697_abnormal_copulation0.80828508
78MP0005083_abnormal_biliary_tract0.80024758
79MP0003693_abnormal_embryo_hatching0.77614350
80MP0002095_abnormal_skin_pigmentation0.77567030
81MP0005075_abnormal_melanosome_morpholog0.76361140
82MP0004134_abnormal_chest_morphology0.75674005
83MP0009763_increased_sensitivity_to0.75252341
84MP0009643_abnormal_urine_homeostasis0.74754135
85MP0009764_decreased_sensitivity_to0.73913722
86MP0008961_abnormal_basal_metabolism0.72980021
87MP0005171_absent_coat_pigmentation0.71612533
88MP0000631_abnormal_neuroendocrine_gland0.71383923
89MP0001968_abnormal_touch/_nociception0.71356993
90MP0002136_abnormal_kidney_physiology0.71313880
91MP0005085_abnormal_gallbladder_physiolo0.69991533
92MP0008057_abnormal_DNA_replication0.68692981
93MP0002736_abnormal_nociception_after0.67063945
94MP0003718_maternal_effect0.66603139
95MP0005166_decreased_susceptibility_to0.66383058
96MP0005464_abnormal_platelet_physiology0.64619015
97MP0006072_abnormal_retinal_apoptosis0.63778706
98MP0002019_abnormal_tumor_incidence0.61583225
99MP0001765_abnormal_ion_homeostasis0.60794506
100MP0003436_decreased_susceptibility_to0.60115887

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.70349976
2IgG deficiency (HP:0004315)4.17328260
3Aplastic anemia (HP:0001915)3.71785836
4Acute necrotizing encephalopathy (HP:0006965)3.65039671
5Mitochondrial inheritance (HP:0001427)3.52316008
6Agammaglobulinemia (HP:0004432)3.39704122
7Lipid accumulation in hepatocytes (HP:0006561)3.28547955
8Hypothermia (HP:0002045)3.27095762
9Increased IgM level (HP:0003496)3.17330959
10Abnormality of T cell physiology (HP:0011840)3.16657514
11Abnormal mitochondria in muscle tissue (HP:0008316)3.16393059
12Increased CSF lactate (HP:0002490)3.15475646
13Abnormality of the prostate (HP:0008775)3.09690583
14Acute encephalopathy (HP:0006846)3.07597889
15Increased hepatocellular lipid droplets (HP:0006565)3.00895320
16Progressive macrocephaly (HP:0004481)2.95988904
17Gastrointestinal infarctions (HP:0005244)2.84132863
18Abnormality of T cells (HP:0002843)2.82146207
19Abnormal number of erythroid precursors (HP:0012131)2.81323609
20Exertional dyspnea (HP:0002875)2.79876294
21Recurrent bronchitis (HP:0002837)2.79815751
22Polydipsia (HP:0001959)2.78648547
23Abnormal drinking behavior (HP:0030082)2.78648547
24Cerebral edema (HP:0002181)2.78334619
25Meningitis (HP:0001287)2.70304513
26Chronic diarrhea (HP:0002028)2.68307979
27Renal Fanconi syndrome (HP:0001994)2.67299320
28IgA deficiency (HP:0002720)2.66168887
29Abnormality of cells of the erythroid lineage (HP:0012130)2.65347851
30Vasculitis (HP:0002633)2.62120972
31Hypomagnesemia (HP:0002917)2.59879673
32Lymphopenia (HP:0001888)2.54922822
33Recurrent sinusitis (HP:0011108)2.54643666
34Tetany (HP:0001281)2.54328922
35Congenital stationary night blindness (HP:0007642)2.53577266
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51830455
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51830455
38Methylmalonic acidemia (HP:0002912)2.50616453
39Hepatocellular necrosis (HP:0001404)2.49650892
40Hypoproteinemia (HP:0003075)2.49486684
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.48447400
42Increased intramyocellular lipid droplets (HP:0012240)2.47614803
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.45259973
44Elevated erythrocyte sedimentation rate (HP:0003565)2.44312439
45Autoimmune hemolytic anemia (HP:0001890)2.42295130
46Abnormality of magnesium homeostasis (HP:0004921)2.42234331
473-Methylglutaconic aciduria (HP:0003535)2.42102689
48Increased muscle lipid content (HP:0009058)2.39314771
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37826662
50Abnormality of B cell number (HP:0010975)2.36535348
51Neutropenia (HP:0001875)2.34238521
52Hepatic necrosis (HP:0002605)2.30533802
53Obstructive lung disease (HP:0006536)2.29138982
54Chronic obstructive pulmonary disease (HP:0006510)2.29138982
55Methylmalonic aciduria (HP:0012120)2.28621359
56Abnormality of male internal genitalia (HP:0000022)2.22714008
57Polyuria (HP:0000103)2.21339797
58Gastrointestinal stroma tumor (HP:0100723)2.18162657
59Panhypogammaglobulinemia (HP:0003139)2.14756873
60Lethargy (HP:0001254)2.14415996
61Abnormality of T cell number (HP:0011839)2.13752244
62Pancreatic cysts (HP:0001737)2.11514205
63Increased serum lactate (HP:0002151)2.11349662
64Hemoptysis (HP:0002105)2.02060942
65Respiratory difficulties (HP:0002880)2.01794368
66Lactic acidosis (HP:0003128)2.01035147
67Optic disc pallor (HP:0000543)1.98457654
68Recurrent fungal infections (HP:0002841)1.97954224
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97859612
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96024597
71Congenital, generalized hypertrichosis (HP:0004540)1.95654334
72B lymphocytopenia (HP:0010976)1.95476977
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93511995
74Dicarboxylic aciduria (HP:0003215)1.93511995
75Prostate neoplasm (HP:0100787)1.93436093
76Abnormality of midbrain morphology (HP:0002418)1.93092567
77Molar tooth sign on MRI (HP:0002419)1.93092567
78Decreased central vision (HP:0007663)1.92172187
79Abnormality of macrophages (HP:0004311)1.91173695
80Severe combined immunodeficiency (HP:0004430)1.91130629
81Skin rash (HP:0000988)1.91115011
82T lymphocytopenia (HP:0005403)1.89572004
83IgM deficiency (HP:0002850)1.88583341
84Patent foramen ovale (HP:0001655)1.88514185
85Abnormality of the pons (HP:0007361)1.86462151
86Urticaria (HP:0001025)1.86447471
87Microretrognathia (HP:0000308)1.86175987
88Abnormal rod and cone electroretinograms (HP:0008323)1.85837739
89Macrocytic anemia (HP:0001972)1.85501099
90Petechiae (HP:0000967)1.83963285
91Cerebral hemorrhage (HP:0001342)1.83758835
92Chronic sinusitis (HP:0011109)1.82847490
93Recurrent pneumonia (HP:0006532)1.82695866
94Abnormal urine output (HP:0012590)1.80716242
95Lymphoma (HP:0002665)1.80694155
96Homocystinuria (HP:0002156)1.80657415
97Abnormality of homocysteine metabolism (HP:0010919)1.80657415
98Recurrent cutaneous fungal infections (HP:0011370)1.78648414
99Chronic mucocutaneous candidiasis (HP:0002728)1.78648414
100Abnormality of eosinophils (HP:0001879)1.78094122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.69070618
2BCKDK4.36571940
3VRK14.16907619
4TXK4.00829619
5TLK13.66885790
6ZAK3.52077055
7KDR2.66996388
8NUAK12.04051779
9MAP4K11.97736664
10MAP3K121.84937921
11STK161.79701730
12DAPK31.78908688
13RPS6KA51.76785138
14ADRBK21.67228589
15IKBKB1.66619850
16MAP4K21.65211696
17GRK11.64706693
18BTK1.55729689
19WNK31.54743436
20BUB11.51083031
21TEC1.50871565
22TIE11.49465855
23MST41.47321815
24TAF11.47233793
25TAOK31.46311412
26FRK1.42119793
27SYK1.40875247
28ABL21.30297869
29ITK1.29275001
30CDK191.19785823
31KIT1.18346919
32MUSK1.14800315
33IKBKE1.14369534
34TNK21.10573420
35PRKCQ1.04746001
36TRIM281.03198432
37LYN1.01115603
38PDK20.98852019
39JAK30.98739551
40FES0.95323155
41IRAK40.91932267
42NEK20.88882304
43NME10.83947035
44WNK40.81271244
45SMG10.80419969
46MAPK150.79841945
47MAPKAPK30.79699322
48MAP2K60.79155556
49DAPK10.78091991
50RPS6KA60.76394598
51LCK0.75975286
52AURKA0.74050486
53INSRR0.72401451
54TBK10.72152837
55CHUK0.70150141
56CSK0.69748037
57CSF1R0.68591780
58CDK120.67359161
59RIPK40.65205358
60MATK0.64764033
61RPS6KB20.64006739
62BMPR20.63677847
63MAPKAPK50.61385416
64CSNK1G30.60266274
65OXSR10.59591240
66TESK20.56774737
67MAP3K90.53916540
68RPS6KC10.50613624
69RPS6KL10.50613624
70MYLK0.49328392
71PASK0.48784130
72PDK10.47459511
73PIK3CA0.47016584
74AURKB0.45558063
75PIM20.45128650
76CSNK1G10.43780771
77HIPK20.43066355
78CDK70.42769575
79MAP2K20.42328384
80IGF1R0.42113845
81CSNK1A1L0.40427002
82EIF2AK20.40082824
83CSNK2A20.38775640
84ABL10.38690088
85PKN10.38052127
86PLK30.37641068
87MAP3K140.36123213
88CSNK2A10.35980584
89MAP3K110.35440772
90OBSCN0.35415155
91MAPKAPK20.34911133
92PIM10.34892876
93PRKCA0.34002477
94GRK70.33378803
95PRKACA0.33327772
96BMPR1B0.32720637
97GRK60.31339032
98EIF2AK30.31288431
99CSNK1G20.29743985
100GRK50.28735613

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.46536278
2Allograft rejection_Homo sapiens_hsa053304.03436675
3Autoimmune thyroid disease_Homo sapiens_hsa053203.95730978
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.94121262
5Primary immunodeficiency_Homo sapiens_hsa053403.69048564
6Systemic lupus erythematosus_Homo sapiens_hsa053223.51329561
7Graft-versus-host disease_Homo sapiens_hsa053323.33889819
8Type I diabetes mellitus_Homo sapiens_hsa049403.04523160
9Proteasome_Homo sapiens_hsa030502.91717480
10Oxidative phosphorylation_Homo sapiens_hsa001902.91444013
11Ribosome_Homo sapiens_hsa030102.62729597
12Parkinsons disease_Homo sapiens_hsa050122.25569040
13Rheumatoid arthritis_Homo sapiens_hsa053232.06348695
14RNA polymerase_Homo sapiens_hsa030202.00061367
15Antigen processing and presentation_Homo sapiens_hsa046121.88144685
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79369188
17Viral myocarditis_Homo sapiens_hsa054161.72425932
18Alcoholism_Homo sapiens_hsa050341.68279222
19Protein export_Homo sapiens_hsa030601.60409035
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54226356
21Huntingtons disease_Homo sapiens_hsa050161.54119727
22Hematopoietic cell lineage_Homo sapiens_hsa046401.47226985
23Alzheimers disease_Homo sapiens_hsa050101.37657194
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31597673
25One carbon pool by folate_Homo sapiens_hsa006701.22713479
26Homologous recombination_Homo sapiens_hsa034401.10368025
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05375050
28Basal transcription factors_Homo sapiens_hsa030221.03638931
29Caffeine metabolism_Homo sapiens_hsa002321.03555607
30Cardiac muscle contraction_Homo sapiens_hsa042601.00697035
31Leishmaniasis_Homo sapiens_hsa051401.00025449
32Staphylococcus aureus infection_Homo sapiens_hsa051500.99407470
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99370434
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94678672
35Maturity onset diabetes of the young_Homo sapiens_hsa049500.94460215
36Sulfur relay system_Homo sapiens_hsa041220.87363510
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87281963
38RNA degradation_Homo sapiens_hsa030180.85105794
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84838667
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79756817
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79603146
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.76760644
43Mismatch repair_Homo sapiens_hsa034300.75188245
44Peroxisome_Homo sapiens_hsa041460.73998768
45Nucleotide excision repair_Homo sapiens_hsa034200.72795892
46Linoleic acid metabolism_Homo sapiens_hsa005910.71366600
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68915826
48Pyrimidine metabolism_Homo sapiens_hsa002400.68349329
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64994111
50T cell receptor signaling pathway_Homo sapiens_hsa046600.64944331
51Phototransduction_Homo sapiens_hsa047440.64646885
52Sulfur metabolism_Homo sapiens_hsa009200.64611905
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64336627
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.62715342
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62410222
56Collecting duct acid secretion_Homo sapiens_hsa049660.61442610
57Retinol metabolism_Homo sapiens_hsa008300.60861875
58Herpes simplex infection_Homo sapiens_hsa051680.59346980
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58268075
60Purine metabolism_Homo sapiens_hsa002300.57319986
61Chemical carcinogenesis_Homo sapiens_hsa052040.55786692
62Butanoate metabolism_Homo sapiens_hsa006500.53185723
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50289419
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.49825267
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49808985
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.49115141
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48290104
68Epstein-Barr virus infection_Homo sapiens_hsa051690.47806189
69Tryptophan metabolism_Homo sapiens_hsa003800.47364180
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46717063
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44446521
72Propanoate metabolism_Homo sapiens_hsa006400.42428726
73DNA replication_Homo sapiens_hsa030300.42082655
74Measles_Homo sapiens_hsa051620.41573263
75Nitrogen metabolism_Homo sapiens_hsa009100.40179551
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39078992
77Arachidonic acid metabolism_Homo sapiens_hsa005900.37687968
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37140755
79beta-Alanine metabolism_Homo sapiens_hsa004100.36564680
80Viral carcinogenesis_Homo sapiens_hsa052030.35650541
81Base excision repair_Homo sapiens_hsa034100.35123198
82Malaria_Homo sapiens_hsa051440.32666081
83Phagosome_Homo sapiens_hsa041450.32324269
84Tuberculosis_Homo sapiens_hsa051520.31645558
85Ether lipid metabolism_Homo sapiens_hsa005650.31112404
86Mineral absorption_Homo sapiens_hsa049780.29759004
87HTLV-I infection_Homo sapiens_hsa051660.29244518
88Histidine metabolism_Homo sapiens_hsa003400.29021673
89Olfactory transduction_Homo sapiens_hsa047400.27548274
90RNA transport_Homo sapiens_hsa030130.27242218
91Vitamin B6 metabolism_Homo sapiens_hsa007500.26928690
92Metabolic pathways_Homo sapiens_hsa011000.25834307
93Fatty acid elongation_Homo sapiens_hsa000620.25470876
94Influenza A_Homo sapiens_hsa051640.23551572
95Tyrosine metabolism_Homo sapiens_hsa003500.22317153
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.21230371
97Regulation of autophagy_Homo sapiens_hsa041400.17801489
98Spliceosome_Homo sapiens_hsa030400.17537246
99Fatty acid metabolism_Homo sapiens_hsa012120.17488320
100ABC transporters_Homo sapiens_hsa020100.17103830

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