PRPS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.28294700
2ribosomal small subunit assembly (GO:0000028)5.17612586
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.03844967
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03844967
5antigen processing and presentation of endogenous antigen (GO:0019883)4.54836992
6positive regulation of gamma-delta T cell activation (GO:0046645)4.41741639
7proteasome assembly (GO:0043248)4.40787283
8DNA strand elongation involved in DNA replication (GO:0006271)4.29046391
9ribosome assembly (GO:0042255)4.28872566
10viral transcription (GO:0019083)4.12283536
11regulation of gamma-delta T cell differentiation (GO:0045586)4.08495507
12DNA strand elongation (GO:0022616)4.07913805
13telomere maintenance via semi-conservative replication (GO:0032201)4.02265984
14translational termination (GO:0006415)4.01217863
15CENP-A containing nucleosome assembly (GO:0034080)3.94269705
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93368940
17chromatin remodeling at centromere (GO:0031055)3.81339550
18purine nucleobase biosynthetic process (GO:0009113)3.80382533
19DNA replication checkpoint (GO:0000076)3.76107694
20deoxyribonucleotide biosynthetic process (GO:0009263)3.71512931
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68685857
22DNA replication initiation (GO:0006270)3.63755827
23translational elongation (GO:0006414)3.62080747
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62076798
25non-recombinational repair (GO:0000726)3.61111400
26double-strand break repair via nonhomologous end joining (GO:0006303)3.61111400
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58989102
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57877787
29folic acid-containing compound biosynthetic process (GO:0009396)3.53731277
30regulation of gamma-delta T cell activation (GO:0046643)3.53478497
31protein localization to kinetochore (GO:0034501)3.51700021
32telomere maintenance via recombination (GO:0000722)3.50976168
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49170316
34mitotic recombination (GO:0006312)3.48099842
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44541876
36IMP biosynthetic process (GO:0006188)3.38923825
37ribosomal small subunit biogenesis (GO:0042274)3.37911641
38protein K6-linked ubiquitination (GO:0085020)3.37397865
39negative regulation of ligase activity (GO:0051352)3.36618331
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36618331
41cotranslational protein targeting to membrane (GO:0006613)3.36125577
42protein targeting to ER (GO:0045047)3.35388741
43nucleobase-containing small molecule interconversion (GO:0015949)3.35212756
44histone exchange (GO:0043486)3.34755086
45V(D)J recombination (GO:0033151)3.34164662
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33070324
47G1/S transition of mitotic cell cycle (GO:0000082)3.26391350
48cell cycle G1/S phase transition (GO:0044843)3.26391350
49pteridine-containing compound biosynthetic process (GO:0042559)3.26137787
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25394368
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25394368
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25394368
53maturation of SSU-rRNA (GO:0030490)3.25241833
54isotype switching (GO:0045190)3.24062802
55somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24062802
56somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24062802
57pore complex assembly (GO:0046931)3.24007120
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23685634
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23685634
60DNA duplex unwinding (GO:0032508)3.23609800
61DNA geometric change (GO:0032392)3.23401486
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22161729
63IMP metabolic process (GO:0046040)3.21871766
64B cell receptor signaling pathway (GO:0050853)3.21077864
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19817126
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.19817126
67positive regulation of B cell differentiation (GO:0045579)3.19764943
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19139323
69negative regulation of phagocytosis (GO:0050765)3.17485947
70regulation of B cell receptor signaling pathway (GO:0050855)3.15852694
71translesion synthesis (GO:0019985)3.14954668
72mitotic chromosome condensation (GO:0007076)3.12395963
73antigen processing and presentation via MHC class Ib (GO:0002475)3.11889840
74cellular protein complex disassembly (GO:0043624)3.11853880
75translational initiation (GO:0006413)3.11832884
76protein localization to endoplasmic reticulum (GO:0070972)3.11532958
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.11310643
78synapsis (GO:0007129)3.10658118
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.09946969
80viral life cycle (GO:0019058)3.08727027
81regulation of cellular amino acid metabolic process (GO:0006521)3.08411963
82DNA catabolic process, exonucleolytic (GO:0000738)3.08050242
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07634979
84regulation of translational termination (GO:0006449)3.07596367
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06347295
86tetrahydrofolate metabolic process (GO:0046653)3.04414418
87telomere maintenance via telomere lengthening (GO:0010833)3.03643386
88rRNA modification (GO:0000154)3.03027702
89DNA ligation (GO:0006266)3.02315173
90positive regulation of ligase activity (GO:0051351)3.01262372
91mitotic metaphase plate congression (GO:0007080)3.00472594
92negative T cell selection (GO:0043383)3.00448157
93protein localization to chromosome, centromeric region (GO:0071459)2.99484934
94regulation of centriole replication (GO:0046599)2.95521889
95deoxyribose phosphate biosynthetic process (GO:0046385)2.93041585
962-deoxyribonucleotide biosynthetic process (GO:0009265)2.93041585
97transcription-coupled nucleotide-excision repair (GO:0006283)2.92941575
98somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.92831048
99somatic cell DNA recombination (GO:0016444)2.92831048
100formation of translation preinitiation complex (GO:0001731)2.92602065
101regulation of mitotic spindle checkpoint (GO:1903504)2.91883389
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91883389
103mitotic nuclear envelope disassembly (GO:0007077)2.91423162
104DNA replication-independent nucleosome assembly (GO:0006336)2.91421674
105DNA replication-independent nucleosome organization (GO:0034724)2.91421674
106regulation of DNA endoreduplication (GO:0032875)2.91209643
107maturation of 5.8S rRNA (GO:0000460)2.90944152
108mitotic sister chromatid cohesion (GO:0007064)2.90902238
109kinetochore organization (GO:0051383)2.90748005
110cullin deneddylation (GO:0010388)2.89849757
111metaphase plate congression (GO:0051310)2.88991033
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87891911
113protein complex disassembly (GO:0043241)2.87406202
114regulation of B cell differentiation (GO:0045577)2.86527559
115somatic recombination of immunoglobulin gene segments (GO:0016447)2.85585491
116DNA double-strand break processing (GO:0000729)2.84844259
117regulation of ubiquitin-protein transferase activity (GO:0051438)2.84646461
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84207223
119replication fork processing (GO:0031297)2.82235347
120regulation of ligase activity (GO:0051340)2.81335958
121sister chromatid segregation (GO:0000819)2.81150991
122nuclear pore organization (GO:0006999)2.80278358
123DNA topological change (GO:0006265)2.80231066
124positive regulation of chromosome segregation (GO:0051984)2.79701165
125protein deneddylation (GO:0000338)2.79357996
126chromosome segregation (GO:0007059)2.78775647
127nuclear pore complex assembly (GO:0051292)2.77561790
128tRNA aminoacylation for protein translation (GO:0006418)2.77547674
129somatic diversification of immune receptors (GO:0002200)2.76128904
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74515640
131cellular hyperosmotic response (GO:0071474)2.73996678
132nuclear-transcribed mRNA catabolic process (GO:0000956)2.70476552
133ribosomal large subunit biogenesis (GO:0042273)2.70357105
134nucleobase biosynthetic process (GO:0046112)2.67142805
135T cell homeostasis (GO:0043029)2.66128115
136membrane disassembly (GO:0030397)2.65987629
137nuclear envelope disassembly (GO:0051081)2.65987629
138macromolecular complex disassembly (GO:0032984)2.65955255
139hepatocyte apoptotic process (GO:0097284)2.65918312
140positive thymic T cell selection (GO:0045059)2.65801386
141negative regulation of RNA splicing (GO:0033119)2.65680474
142mitotic sister chromatid segregation (GO:0000070)2.63970512
143negative thymic T cell selection (GO:0045060)2.63197429
144telomere maintenance (GO:0000723)2.62845985
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.60895524
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60895524
147mast cell activation (GO:0045576)2.60869797
148establishment of integrated proviral latency (GO:0075713)2.60686332
149telomere organization (GO:0032200)2.59870003
150postreplication repair (GO:0006301)2.57904407
151DNA conformation change (GO:0071103)2.56747221
152mRNA catabolic process (GO:0006402)2.56523176
153regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56119780
154positive T cell selection (GO:0043368)2.51446767
155angiogenesis involved in wound healing (GO:0060055)2.50682813
156B cell mediated immunity (GO:0019724)2.50658339
157RNA catabolic process (GO:0006401)2.50547157
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49374658
159cellular response to zinc ion (GO:0071294)2.48351652
160DNA replication-dependent nucleosome assembly (GO:0006335)2.48053042
161DNA replication-dependent nucleosome organization (GO:0034723)2.48053042
162dosage compensation (GO:0007549)2.47583072
163antigen receptor-mediated signaling pathway (GO:0050851)2.46194649
164regulation of interleukin-12 biosynthetic process (GO:0045075)2.46099537
165T cell apoptotic process (GO:0070231)2.45637880
166definitive hemopoiesis (GO:0060216)2.43467425
167positive regulation of lamellipodium assembly (GO:0010592)2.42949273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.16749782
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.78862913
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.52890654
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21186778
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10163449
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04698011
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.98579486
8MYC_22102868_ChIP-Seq_BL_Human2.80832356
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.66806802
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53070183
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42884725
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35167174
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25028296
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19467017
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15699141
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11645477
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11249712
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03100470
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96519833
20VDR_21846776_ChIP-Seq_THP-1_Human1.95186985
21MYB_26560356_Chip-Seq_TH2_Human1.91130805
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90362214
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90216692
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90193379
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88447747
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87280068
27AR_21909140_ChIP-Seq_LNCAP_Human1.86875079
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83104336
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79192350
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.78647012
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.78283470
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.76462959
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74817013
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74757244
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73553583
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73043949
37SCL_19346495_ChIP-Seq_HPC-7_Human1.72958600
38MAF_26560356_Chip-Seq_TH1_Human1.68512446
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.66864944
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64608671
41MYB_26560356_Chip-Seq_TH1_Human1.64152706
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64133119
43SPI1_23547873_ChIP-Seq_NB4_Human1.62535255
44VDR_23849224_ChIP-Seq_CD4+_Human1.62334116
45XRN2_22483619_ChIP-Seq_HELA_Human1.62223260
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60463067
47GATA1_22025678_ChIP-Seq_K562_Human1.59082963
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58774862
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55276602
50UTX_26944678_Chip-Seq_JUKART_Human1.53630210
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52371247
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52295267
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50535354
54FOXP3_21729870_ChIP-Seq_TREG_Human1.50183620
55CIITA_25753668_ChIP-Seq_RAJI_Human1.49616452
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.48758081
57ELK1_19687146_ChIP-ChIP_HELA_Human1.48596670
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46951520
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46862644
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46503340
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43043911
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42855803
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41686793
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38835053
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37756850
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.36781650
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36251068
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35937369
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.34936529
70RUNX_20019798_ChIP-Seq_JUKART_Human1.34125953
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31150996
72* VDR_24763502_ChIP-Seq_THP-1_Human1.30885605
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30349960
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29579981
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26961024
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26924462
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.26855113
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25524703
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25430409
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24474081
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23743753
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23391199
83DCP1A_22483619_ChIP-Seq_HELA_Human1.21961727
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21439405
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20989962
86TCF7_22412390_ChIP-Seq_EML_Mouse1.20291324
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20258984
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20147030
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17923292
90TTF2_22483619_ChIP-Seq_HELA_Human1.14611086
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14312992
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13968049
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13724496
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11907393
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11537022
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10329689
97KDM5A_27292631_Chip-Seq_BREAST_Human1.10060422
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.09992761
99MYC_18940864_ChIP-ChIP_HL60_Human1.09458901
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08154718
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07670491
102TFEB_21752829_ChIP-Seq_HELA_Human1.07616939
103GABP_19822575_ChIP-Seq_HepG2_Human1.05484405
104GATA3_27048872_Chip-Seq_THYMUS_Human1.04067095
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03378655
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01850485
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01336958
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00794190
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00046426
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99779239
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99626978
112* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99495022
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98865288
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98702732
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95988098
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95481936
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95329036
118MAF_26560356_Chip-Seq_TH2_Human0.94162355
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92385074
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92348494
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91418867
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.91125913
123ZNF263_19887448_ChIP-Seq_K562_Human0.89865934
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.88803499
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88744698
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88349888
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87633618
128BP1_19119308_ChIP-ChIP_Hs578T_Human0.87108406
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87044176
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86890990
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86003779
132ELF5_23300383_ChIP-Seq_T47D_Human0.85167318
133CHD1_26751641_Chip-Seq_LNCaP_Human0.82647273
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81046498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.45547503
2MP0001835_abnormal_antigen_presentation3.10803616
3MP0003763_abnormal_thymus_physiology2.93383574
4MP0010094_abnormal_chromosome_stability2.87675393
5MP0003806_abnormal_nucleotide_metabolis2.84123618
6MP0005671_abnormal_response_to2.69357168
7MP0000372_irregular_coat_pigmentation2.56175678
8MP0010352_gastrointestinal_tract_polyps2.54456308
9MP0000685_abnormal_immune_system2.53715379
10MP0003693_abnormal_embryo_hatching2.47032752
11MP0003718_maternal_effect2.41708320
12MP0006054_spinal_hemorrhage2.38788682
13MP0002166_altered_tumor_susceptibility2.37778768
14MP0008057_abnormal_DNA_replication2.32038873
15MP0001800_abnormal_humoral_immune2.30414199
16MP0004957_abnormal_blastocyst_morpholog2.30257207
17MP0003077_abnormal_cell_cycle2.29693249
18MP0009697_abnormal_copulation2.27062684
19MP0002398_abnormal_bone_marrow2.26319573
20MP0004808_abnormal_hematopoietic_stem2.17935760
21MP0003300_gastrointestinal_ulcer2.13854301
22MP0000703_abnormal_thymus_morphology2.06438088
23MP0002420_abnormal_adaptive_immunity2.03091952
24MP0002452_abnormal_antigen_presenting2.01322642
25MP0003111_abnormal_nucleus_morphology2.00344053
26MP0001819_abnormal_immune_cell1.98422219
27MP0001790_abnormal_immune_system1.97422428
28MP0005387_immune_system_phenotype1.97422428
29MP0008007_abnormal_cellular_replicative1.96808219
30MP0000689_abnormal_spleen_morphology1.95760393
31MP0002722_abnormal_immune_system1.94785160
32MP0000490_abnormal_crypts_of1.94345645
33MP0000716_abnormal_immune_system1.91963190
34MP0002723_abnormal_immune_serum1.90769444
35MP0002006_tumorigenesis1.88532490
36MP0009333_abnormal_splenocyte_physiolog1.87729663
37MP0005000_abnormal_immune_tolerance1.86241535
38MP0001881_abnormal_mammary_gland1.86091345
39MP0009785_altered_susceptibility_to1.77433226
40MP0002429_abnormal_blood_cell1.73903339
41MP0010155_abnormal_intestine_physiology1.72769318
42MP0010307_abnormal_tumor_latency1.72261878
43MP0010234_abnormal_vibrissa_follicle1.66796343
44MP0005025_abnormal_response_to1.66703249
45MP0003436_decreased_susceptibility_to1.65285349
46MP0001545_abnormal_hematopoietic_system1.62981947
47MP0005397_hematopoietic_system_phenotyp1.62981947
48MP0003950_abnormal_plasma_membrane1.62523001
49MP0002405_respiratory_system_inflammati1.60479208
50MP0002019_abnormal_tumor_incidence1.49691683
51MP0005464_abnormal_platelet_physiology1.49347736
52MP0006036_abnormal_mitochondrial_physio1.46675221
53MP0000858_altered_metastatic_potential1.45189553
54MP0002148_abnormal_hypersensitivity_rea1.44139905
55MP0004947_skin_inflammation1.40949142
56MP0002419_abnormal_innate_immunity1.40720448
57MP0003186_abnormal_redox_activity1.38891206
58MP0001873_stomach_inflammation1.37663852
59MP0002009_preneoplasia1.36014088
60MP0000350_abnormal_cell_proliferation1.35106800
61MP0005408_hypopigmentation1.33988272
62MP0000465_gastrointestinal_hemorrhage1.32130735
63MP0000358_abnormal_cell_content/1.31557774
64MP0001730_embryonic_growth_arrest1.27394074
65MP0003724_increased_susceptibility_to1.25699478
66MP0001845_abnormal_inflammatory_respons1.25013364
67MP0008058_abnormal_DNA_repair1.23917237
68MP0001661_extended_life_span1.22949304
69MP0001853_heart_inflammation1.18245605
70MP0002163_abnormal_gland_morphology1.17734296
71MP0003866_abnormal_defecation1.17332816
72MP0002132_abnormal_respiratory_system1.16932458
73MP0005174_abnormal_tail_pigmentation1.15567122
74MP0009278_abnormal_bone_marrow1.12820281
75MP0000627_abnormal_mammary_gland1.12680747
76MP0008995_early_reproductive_senescence1.10664799
77MP0003448_altered_tumor_morphology1.09066382
78MP0006035_abnormal_mitochondrial_morpho1.08005316
79MP0002095_abnormal_skin_pigmentation1.07877971
80MP0005023_abnormal_wound_healing1.06131557
81MP0003303_peritoneal_inflammation1.03352347
82MP0006082_CNS_inflammation1.02448251
83MP0000313_abnormal_cell_death1.02295585
84MP0005058_abnormal_lysosome_morphology1.01371219
85MP0008877_abnormal_DNA_methylation1.00674073
86MP0002160_abnormal_reproductive_system1.00014763
87MP0005395_other_phenotype0.97555024
88MP0008875_abnormal_xenobiotic_pharmacok0.96487294
89MP0002933_joint_inflammation0.96348230
90MP0003566_abnormal_cell_adhesion0.96094118
91MP0001929_abnormal_gametogenesis0.95667258
92MP0005076_abnormal_cell_differentiation0.95602723
93MP0002877_abnormal_melanocyte_morpholog0.93991829
94MP0008932_abnormal_embryonic_tissue0.91995170
95MP0003172_abnormal_lysosome_physiology0.91706824
96MP0005379_endocrine/exocrine_gland_phen0.90685947
97MP0002210_abnormal_sex_determination0.90524586
98MP0001216_abnormal_epidermal_layer0.85641902
99MP0002086_abnormal_extraembryonic_tissu0.85579678
100MP0001915_intracranial_hemorrhage0.85432178
101MP0005501_abnormal_skin_physiology0.85147118
102MP0001145_abnormal_male_reproductive0.84786080
103MP0002080_prenatal_lethality0.84716219
104MP0000477_abnormal_intestine_morphology0.84022357
105MP0001697_abnormal_embryo_size0.83673175
106MP0000015_abnormal_ear_pigmentation0.83384547
107MP0005389_reproductive_system_phenotype0.82090878
108MP0003984_embryonic_growth_retardation0.81750803
109MP0008469_abnormal_protein_level0.81568060
110MP0003567_abnormal_fetal_cardiomyocyte0.81468764
111MP0000653_abnormal_sex_gland0.81159334
112MP0002088_abnormal_embryonic_growth/wei0.79574692
113MP0001958_emphysema0.79552409
114MP0001764_abnormal_homeostasis0.79316265
115MP0001727_abnormal_embryo_implantation0.78686490
116MP0005384_cellular_phenotype0.78128486
117MP0001119_abnormal_female_reproductive0.77806216
118MP0003943_abnormal_hepatobiliary_system0.76047975
119MP0001672_abnormal_embryogenesis/_devel0.75827343
120MP0005380_embryogenesis_phenotype0.75827343
121MP0005075_abnormal_melanosome_morpholog0.74455771
122MP0002060_abnormal_skin_morphology0.74393167
123MP0010678_abnormal_skin_adnexa0.74132524
124MP0005647_abnormal_sex_gland0.74027068
125MP0004147_increased_porphyrin_level0.73494666
126MP0001849_ear_inflammation0.73386904
127MP0002796_impaired_skin_barrier0.72362200
128MP0001533_abnormal_skeleton_physiology0.71826757
129MP0003279_aneurysm0.71364763
130MP0005220_abnormal_exocrine_pancreas0.71337945
131MP0000383_abnormal_hair_follicle0.70433534
132MP0003786_premature_aging0.70383436
133MP0003941_abnormal_skin_development0.69271543
134MP0000371_diluted_coat_color0.68738851
135MP0005621_abnormal_cell_physiology0.67935339
136MP0001919_abnormal_reproductive_system0.66585774
137MP0008004_abnormal_stomach_pH0.66428984
138MP0003453_abnormal_keratinocyte_physiol0.65581856
139MP0003699_abnormal_female_reproductive0.64759759
140MP0004197_abnormal_fetal_growth/weight/0.64509190
141MP0000613_abnormal_salivary_gland0.64198162
142MP0002136_abnormal_kidney_physiology0.62870732
143MP0003828_pulmonary_edema0.61046232
144MP0003705_abnormal_hypodermis_morpholog0.61034198
145MP0004782_abnormal_surfactant_physiolog0.60399517
146MP0008873_increased_physiological_sensi0.58840317
147MP0002085_abnormal_embryonic_tissue0.58678606

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.47490255
2T lymphocytopenia (HP:0005403)4.64802919
3Abnormality of T cell number (HP:0011839)4.37895982
4Recurrent viral infections (HP:0004429)4.22110549
5Abnormality of B cell number (HP:0010975)4.15624628
6B lymphocytopenia (HP:0010976)4.15624628
7IgM deficiency (HP:0002850)4.12816205
8Abnormality of the preputium (HP:0100587)3.93663611
9Panhypogammaglobulinemia (HP:0003139)3.74202464
10Thrombocytosis (HP:0001894)3.70712655
11Reticulocytopenia (HP:0001896)3.70221562
12Abnormality of T cells (HP:0002843)3.62463672
13Chronic otitis media (HP:0000389)3.57634731
14Recurrent bronchitis (HP:0002837)3.51755492
15Meckel diverticulum (HP:0002245)3.34304362
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.29707771
17Elevated erythrocyte sedimentation rate (HP:0003565)3.27209041
18Abnormality of glycolysis (HP:0004366)3.19518549
19Abnormality of the ileum (HP:0001549)3.15746473
20Interstitial pulmonary disease (HP:0006530)3.14558424
21Small intestinal stenosis (HP:0012848)3.13053608
22Duodenal stenosis (HP:0100867)3.13053608
23Hypoplasia of the thymus (HP:0000778)3.07265353
24IgG deficiency (HP:0004315)3.06079004
25Microvesicular hepatic steatosis (HP:0001414)3.05931811
26Cholecystitis (HP:0001082)3.05109736
27Abnormal gallbladder physiology (HP:0012438)3.05109736
28Thyroiditis (HP:0100646)3.03964615
29Agnosia (HP:0010524)2.97945579
30Myositis (HP:0100614)2.94098096
31Severe combined immunodeficiency (HP:0004430)2.93624273
32Clubbing of toes (HP:0100760)2.93157681
33Combined immunodeficiency (HP:0005387)2.91675873
34Cellulitis (HP:0100658)2.91576039
35Aplastic anemia (HP:0001915)2.90208937
36Recurrent fungal infections (HP:0002841)2.90047391
37Abnormality of cells of the erythroid lineage (HP:0012130)2.88995553
38Colon cancer (HP:0003003)2.82539640
39Lymphoma (HP:0002665)2.79647046
40Eosinophilia (HP:0001880)2.78586629
41Basal cell carcinoma (HP:0002671)2.77110794
42Birth length less than 3rd percentile (HP:0003561)2.76962837
43Increased hepatocellular lipid droplets (HP:0006565)2.75299439
44Abnormality of methionine metabolism (HP:0010901)2.74838768
45Abnormal number of erythroid precursors (HP:0012131)2.74625956
46Papilledema (HP:0001085)2.74220949
47Abnormality of T cell physiology (HP:0011840)2.73650652
48Prostate neoplasm (HP:0100787)2.73081009
49Meningitis (HP:0001287)2.62813282
50Lymphopenia (HP:0001888)2.61459167
51IgA deficiency (HP:0002720)2.59175028
52Agammaglobulinemia (HP:0004432)2.58947893
53Granulocytopenia (HP:0001913)2.56784391
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.56635305
55Increased serum pyruvate (HP:0003542)2.55475735
56Petechiae (HP:0000967)2.54730591
57Papilloma (HP:0012740)2.52676338
58Verrucae (HP:0200043)2.52676338
59Breast carcinoma (HP:0003002)2.50659222
60Duplicated collecting system (HP:0000081)2.49884866
61Pancytopenia (HP:0001876)2.48862340
62Hypoplasia of the uterus (HP:0000013)2.47940166
63Cutaneous melanoma (HP:0012056)2.46259524
64Amaurosis fugax (HP:0100576)2.41764372
65Increased CSF lactate (HP:0002490)2.40688121
66Poikiloderma (HP:0001029)2.38406726
67Type I transferrin isoform profile (HP:0003642)2.36030823
68Hypoproteinemia (HP:0003075)2.35636922
69Increased serum lactate (HP:0002151)2.34086339
70Inflammation of the large intestine (HP:0002037)2.34074282
71Gastrointestinal inflammation (HP:0004386)2.33829249
72Osteomyelitis (HP:0002754)2.32708552
73Lipid accumulation in hepatocytes (HP:0006561)2.31490746
74Sparse eyelashes (HP:0000653)2.28350421
75Abnormality of the fingertips (HP:0001211)2.27742569
76Abnormality of the duodenum (HP:0002246)2.27275445
77Hepatocellular necrosis (HP:0001404)2.26385972
78Hepatic necrosis (HP:0002605)2.24347276
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.24127439
80Reduced antithrombin III activity (HP:0001976)2.23942292
81Autoimmune thrombocytopenia (HP:0001973)2.23312374
82Nephroblastoma (Wilms tumor) (HP:0002667)2.21846469
83Hematochezia (HP:0002573)2.19533364
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.18890197
85Osteolytic defects of the hand bones (HP:0009699)2.18890197
86Abnormality of the carotid arteries (HP:0005344)2.16821154
87Testicular atrophy (HP:0000029)2.15746928
88Aplasia/Hypoplasia of the thymus (HP:0010515)2.15510773
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13661031
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13472948
91Recurrent abscess formation (HP:0002722)2.13106021
92Aortic aneurysm (HP:0004942)2.12228988
93Eczematoid dermatitis (HP:0000976)2.12134297
94Abnormality of the prostate (HP:0008775)2.11221417
95Embryonal renal neoplasm (HP:0011794)2.10380094
96Mitochondrial inheritance (HP:0001427)2.10232447
97Abnormality of the renal collecting system (HP:0004742)2.10138014
98Increased density of long bones (HP:0006392)2.09870560
99Acute myeloid leukemia (HP:0004808)2.09792307
100Absent thumb (HP:0009777)2.08961654
101Ependymoma (HP:0002888)2.08751088
102Bicuspid aortic valve (HP:0001647)2.07278781
103Ureteral duplication (HP:0000073)2.06206402
104Acute encephalopathy (HP:0006846)2.05945273
105Neoplasm of the adrenal gland (HP:0100631)2.03421499
106Medulloblastoma (HP:0002885)2.03403105
107Myelodysplasia (HP:0002863)2.02412415
108Sloping forehead (HP:0000340)2.02374414
109Abnormality of eosinophils (HP:0001879)2.02332854
110Melanoma (HP:0002861)2.01962576
111Sensory axonal neuropathy (HP:0003390)2.01418056
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00823203
113Abnormal protein N-linked glycosylation (HP:0012347)2.00823203
114Abnormal protein glycosylation (HP:0012346)2.00823203
115Abnormal glycosylation (HP:0012345)2.00823203
116Abnormal platelet volume (HP:0011876)2.00803225
117Cafe-au-lait spot (HP:0000957)2.00264233
118Spontaneous hematomas (HP:0007420)2.00020049
119Cerebral edema (HP:0002181)1.99578962
120Impaired platelet aggregation (HP:0003540)1.99345633
121Abnormal platelet function (HP:0011869)1.99345633
122Pallor (HP:0000980)1.99260599
123Nasal polyposis (HP:0100582)1.98797093
124Gastrointestinal stroma tumor (HP:0100723)1.96635803
125Conjunctival hamartoma (HP:0100780)1.96481591
126Megaloblastic anemia (HP:0001889)1.96319536
127Abnormal spermatogenesis (HP:0008669)1.95605876
128Premature ovarian failure (HP:0008209)1.95423771
129Aplasia/hypoplasia of the uterus (HP:0008684)1.95324895
130Renal Fanconi syndrome (HP:0001994)1.95173155
131Pustule (HP:0200039)1.94927071
132Colitis (HP:0002583)1.94782640
133Posterior subcapsular cataract (HP:0007787)1.94577364
134Leukocytosis (HP:0001974)1.93367504
135Lactic acidosis (HP:0003128)1.93308702
13611 pairs of ribs (HP:0000878)1.92527089
137Acute necrotizing encephalopathy (HP:0006965)1.91158170
138Vasculitis (HP:0002633)1.89909104
139Hypokinesia (HP:0002375)1.89360430
140Volvulus (HP:0002580)1.89186028
141Chronic diarrhea (HP:0002028)1.89097226
142Recurrent bacterial skin infections (HP:0005406)1.88775618
143High pitched voice (HP:0001620)1.88494693
144Entropion (HP:0000621)1.87729220
145Abnormal umbilical cord blood vessels (HP:0011403)1.87482428
146Single umbilical artery (HP:0001195)1.87482428
147Abnormality of the fetal cardiovascular system (HP:0010948)1.87482428
148Bronchitis (HP:0012387)1.86879918
149Neoplasm of the colon (HP:0100273)1.86240368
150Autoimmune hemolytic anemia (HP:0001890)1.85787368
151Degeneration of anterior horn cells (HP:0002398)1.85769780
152Abnormality of the anterior horn cell (HP:0006802)1.85769780
153Short middle phalanx of the 5th finger (HP:0004220)1.85488665
154Abnormality of the nasal mucosa (HP:0000433)1.85092916
155Spondylolisthesis (HP:0003302)1.84708833
156Abnormality of DNA repair (HP:0003254)1.84043572
157Abnormal lung lobation (HP:0002101)1.82931884
158Abnormal mitochondria in muscle tissue (HP:0008316)1.82556475
159Abnormality of chromosome stability (HP:0003220)1.82465979
160Subacute progressive viral hepatitis (HP:0006572)1.82116855
161Abnormality of the umbilical cord (HP:0010881)1.81252251
162Skin ulcer (HP:0200042)1.81086860
163Ulnar bowing (HP:0003031)1.79827623
164Biliary tract neoplasm (HP:0100574)1.78790899
165Secondary amenorrhea (HP:0000869)1.78648683
166Macrocytic anemia (HP:0001972)1.78618261
167Gout (HP:0001997)1.78214835
168Encephalitis (HP:0002383)1.77435243
169Chromsome breakage (HP:0040012)1.77432485
170Increased intramyocellular lipid droplets (HP:0012240)1.76255791
171Gonadotropin excess (HP:0000837)1.75745863
172Persistence of primary teeth (HP:0006335)1.75661158
173Dyschromatopsia (HP:0007641)1.75541549
174Neoplasm of the adrenal cortex (HP:0100641)1.75328674
175Cerebral aneurysm (HP:0004944)1.75247831
176Multiple enchondromatosis (HP:0005701)1.74752770
177Increased nuchal translucency (HP:0010880)1.73878086
178Arteriovenous malformation (HP:0100026)1.73817918
179Progressive macrocephaly (HP:0004481)1.73802221
180Squamous cell carcinoma (HP:0002860)1.72556611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.00925909
2VRK23.12852541
3EEF2K3.07059365
4PKN22.96341073
5STK102.89976717
6FLT32.88083703
7CDC72.71827903
8NUAK12.45852911
9PBK2.29137115
10MAP3K102.27643680
11ZAP702.23825536
12LRRK22.14719751
13TXK2.10931014
14SCYL22.04490498
15ZAK2.01935729
16TGFBR22.00170189
17PLK41.99694042
18RPS6KB21.97303132
19CSF1R1.95036872
20GRK61.94618715
21TRIM281.85125007
22ITK1.70915676
23BTK1.70460362
24EIF2AK21.65953174
25TSSK61.62585922
26NEK21.62186478
27TYK21.59327902
28TAF11.59113682
29MST1R1.58099872
30KIT1.57277302
31EIF2AK31.54177533
32PASK1.52526394
33NME21.52424829
34JAK31.48403254
35WEE11.47188800
36BUB11.41533392
37RPS6KA41.39635613
38MST41.39056072
39ERBB31.37551435
40TEC1.34469492
41SMG11.33799958
42SYK1.32458544
43TGFBR11.32292109
44BMPR21.32003459
45EIF2AK11.30522503
46MAP3K81.23726166
47CHEK21.23089561
48CLK11.18505042
49PDK21.17759745
50PAK41.17644439
51CDK61.17229869
52CDK41.15398722
53TESK21.13420642
54DAPK11.12556519
55STK41.11267660
56ATR1.10606650
57MKNK21.10094585
58STK391.09363117
59LCK1.07925856
60BRSK21.04322682
61CDK121.03358602
62MAP3K140.99816887
63NEK10.99041848
64AURKB0.97056744
65MAP2K30.95964581
66STK160.94690933
67BCKDK0.91086693
68PIM10.90646130
69VRK10.89858190
70SIK30.82859533
71ACVR1B0.82604046
72FGFR30.80431728
73SRPK10.78762202
74LYN0.77992547
75HCK0.77765536
76CSK0.77329556
77MAPKAPK50.76141396
78TRIB30.76049921
79TRPM70.74904433
80BLK0.74068973
81FGFR40.73788813
82TLK10.71945531
83TESK10.71348354
84MAP3K120.71239663
85CCNB10.71124835
86MELK0.69327055
87OXSR10.68424038
88PTK60.67995442
89TBK10.67309622
90ERN10.67293729
91CDK70.66268197
92HIPK20.63912625
93TTK0.63645259
94PRKCI0.62229957
95FGFR10.61046351
96AURKA0.60995658
97CHEK10.60887477
98NEK90.60769376
99ALK0.60059844
100ILK0.58635079
101JAK10.58045583
102MKNK10.55810439
103PRKCQ0.54783155
104BCR0.54730418
105FRK0.54696561
106IRAK30.54302420
107PAK20.53915021
108PLK10.53053422
109MAPKAPK30.52656199
110JAK20.51999585
111NME10.51772648
112PLK20.51763215
113IKBKB0.50853076
114TTN0.50576105
115CSNK2A20.50192707
116PIM20.48108587
117MAPKAPK20.45941021
118CSNK2A10.45675813
119IKBKE0.45356523
120BRD40.43670763
121ATM0.43642890
122RAF10.43589314
123BRSK10.43573710
124CSNK1G30.43499610
125FGFR20.43216220
126NLK0.42000269
127MATK0.41209406
128BRAF0.40474781
129PLK30.40044837
130PDGFRB0.37863833
131ERBB40.37543321
132CDK10.36665968
133CDK20.35495797
134CDK80.34741253
135TAOK30.34349015
136STK240.33972744
137PAK10.33690679
138MAPK110.33579787
139DYRK30.33376626
140STK30.33151402
141CDK90.33025261
142EPHA20.32189809
143KDR0.31752191
144RPS6KA50.30906835
145BMPR1B0.29048070
146FER0.26901427
147CSNK1G10.26740188
148CSNK1A1L0.26205102

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67941750
2Mismatch repair_Homo sapiens_hsa034303.70580405
3Primary immunodeficiency_Homo sapiens_hsa053403.50316146
4Ribosome_Homo sapiens_hsa030102.94340491
5Non-homologous end-joining_Homo sapiens_hsa034502.66046154
6Base excision repair_Homo sapiens_hsa034102.44363375
7Antigen processing and presentation_Homo sapiens_hsa046122.44079547
8One carbon pool by folate_Homo sapiens_hsa006702.26138595
9Protein export_Homo sapiens_hsa030602.21831587
10Nucleotide excision repair_Homo sapiens_hsa034202.05458652
11Spliceosome_Homo sapiens_hsa030402.03409836
12Homologous recombination_Homo sapiens_hsa034401.91197287
13Cell cycle_Homo sapiens_hsa041101.90638378
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85955455
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78737325
16B cell receptor signaling pathway_Homo sapiens_hsa046621.77906617
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.69516462
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.68004929
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64868793
20RNA transport_Homo sapiens_hsa030131.61664055
21Vitamin B6 metabolism_Homo sapiens_hsa007501.52252138
22Hematopoietic cell lineage_Homo sapiens_hsa046401.50270602
23Measles_Homo sapiens_hsa051621.48665393
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48268862
25Basal transcription factors_Homo sapiens_hsa030221.48047029
26T cell receptor signaling pathway_Homo sapiens_hsa046601.46962243
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.45186870
28p53 signaling pathway_Homo sapiens_hsa041151.42858344
29Pyrimidine metabolism_Homo sapiens_hsa002401.39934624
30Herpes simplex infection_Homo sapiens_hsa051681.39434395
31Leishmaniasis_Homo sapiens_hsa051401.39057981
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36148822
33Fatty acid elongation_Homo sapiens_hsa000621.34465845
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33638913
35Pyruvate metabolism_Homo sapiens_hsa006201.33389009
36Propanoate metabolism_Homo sapiens_hsa006401.31967741
37Systemic lupus erythematosus_Homo sapiens_hsa053221.29318664
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29247138
39* Biosynthesis of amino acids_Homo sapiens_hsa012301.24132661
40Viral carcinogenesis_Homo sapiens_hsa052031.23940646
41Allograft rejection_Homo sapiens_hsa053301.19967315
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16829153
43* Carbon metabolism_Homo sapiens_hsa012001.16205940
44RNA degradation_Homo sapiens_hsa030181.15810678
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.14434029
46Proteasome_Homo sapiens_hsa030501.14248853
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13222686
48Chronic myeloid leukemia_Homo sapiens_hsa052201.12688072
49Viral myocarditis_Homo sapiens_hsa054161.10433975
50Fanconi anemia pathway_Homo sapiens_hsa034601.09461061
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08173997
52Osteoclast differentiation_Homo sapiens_hsa043801.07893253
53Legionellosis_Homo sapiens_hsa051341.07891318
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06032543
55Thyroid cancer_Homo sapiens_hsa052161.04462499
56Apoptosis_Homo sapiens_hsa042101.03736627
57Hepatitis B_Homo sapiens_hsa051611.03209688
58Small cell lung cancer_Homo sapiens_hsa052221.02747926
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01069930
60Epstein-Barr virus infection_Homo sapiens_hsa051691.00846547
61HTLV-I infection_Homo sapiens_hsa051661.00202042
62* Pentose phosphate pathway_Homo sapiens_hsa000300.99626258
63Shigellosis_Homo sapiens_hsa051310.96847871
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96172570
65Toxoplasmosis_Homo sapiens_hsa051450.94409284
66Acute myeloid leukemia_Homo sapiens_hsa052210.94235380
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.93528021
68Glutathione metabolism_Homo sapiens_hsa004800.92372709
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92121167
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91316809
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91230997
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91177751
73RNA polymerase_Homo sapiens_hsa030200.89857833
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88393002
75Oxidative phosphorylation_Homo sapiens_hsa001900.88124589
76Colorectal cancer_Homo sapiens_hsa052100.86037267
77Parkinsons disease_Homo sapiens_hsa050120.85823368
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.85743414
79Folate biosynthesis_Homo sapiens_hsa007900.84934102
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84490965
81Pancreatic cancer_Homo sapiens_hsa052120.83105349
82Oocyte meiosis_Homo sapiens_hsa041140.83069575
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80915688
84Sulfur metabolism_Homo sapiens_hsa009200.79995704
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78827426
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78746862
87mRNA surveillance pathway_Homo sapiens_hsa030150.78654273
88Other glycan degradation_Homo sapiens_hsa005110.77282119
89Pertussis_Homo sapiens_hsa051330.76863878
90Graft-versus-host disease_Homo sapiens_hsa053320.75808438
91Influenza A_Homo sapiens_hsa051640.74795559
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.70866655
93MicroRNAs in cancer_Homo sapiens_hsa052060.70020482
94Platelet activation_Homo sapiens_hsa046110.69076479
95Non-small cell lung cancer_Homo sapiens_hsa052230.68822597
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67855466
97N-Glycan biosynthesis_Homo sapiens_hsa005100.67030914
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63044456
99Fructose and mannose metabolism_Homo sapiens_hsa000510.62829269
100Autoimmune thyroid disease_Homo sapiens_hsa053200.62800637
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61634697
102Tuberculosis_Homo sapiens_hsa051520.60973673
103Huntingtons disease_Homo sapiens_hsa050160.60024395
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59314756
105Asthma_Homo sapiens_hsa053100.57661348
106Tryptophan metabolism_Homo sapiens_hsa003800.54474763
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51535889
108Renin-angiotensin system_Homo sapiens_hsa046140.51231938
109Steroid biosynthesis_Homo sapiens_hsa001000.50548247
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49760898
111Galactose metabolism_Homo sapiens_hsa000520.49756434
112* Metabolic pathways_Homo sapiens_hsa011000.49443715
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49185521
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48252611
115Malaria_Homo sapiens_hsa051440.48240011
116Type I diabetes mellitus_Homo sapiens_hsa049400.45830028
117Selenocompound metabolism_Homo sapiens_hsa004500.45008463
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43929638
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.42685222
120Lysosome_Homo sapiens_hsa041420.42394353
121Caffeine metabolism_Homo sapiens_hsa002320.41541051
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40857283
123Chemokine signaling pathway_Homo sapiens_hsa040620.40444194
124Sulfur relay system_Homo sapiens_hsa041220.40106153
125TNF signaling pathway_Homo sapiens_hsa046680.39274600
126Hepatitis C_Homo sapiens_hsa051600.38122308
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37589239
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36895792
129Adherens junction_Homo sapiens_hsa045200.35755288
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35057585
131Salmonella infection_Homo sapiens_hsa051320.34530654
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33366634
133HIF-1 signaling pathway_Homo sapiens_hsa040660.33118667
134* Purine metabolism_Homo sapiens_hsa002300.33113044
135Prostate cancer_Homo sapiens_hsa052150.33008697
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.32945850
137Proteoglycans in cancer_Homo sapiens_hsa052050.32809279
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32798813
139Pathways in cancer_Homo sapiens_hsa052000.32147910
140Alzheimers disease_Homo sapiens_hsa050100.31950051
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31112288
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30736099
143Peroxisome_Homo sapiens_hsa041460.30598972
144Arginine and proline metabolism_Homo sapiens_hsa003300.30502805
145Bladder cancer_Homo sapiens_hsa052190.29085654
146Fatty acid degradation_Homo sapiens_hsa000710.28139371
147Notch signaling pathway_Homo sapiens_hsa043300.27870567
148Fatty acid metabolism_Homo sapiens_hsa012120.27780050
149Tyrosine metabolism_Homo sapiens_hsa003500.26193398
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26070937
151beta-Alanine metabolism_Homo sapiens_hsa004100.20280489
152Lysine degradation_Homo sapiens_hsa003100.18700872
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18172915

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