PRPF4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.43632105
2mRNA splice site selection (GO:0006376)5.37623477
3histone H3-K4 trimethylation (GO:0080182)5.11979093
4ribosomal small subunit biogenesis (GO:0042274)4.98446804
5monoubiquitinated protein deubiquitination (GO:0035520)4.68106849
6regulation of DNA endoreduplication (GO:0032875)4.65982620
7peptidyl-lysine trimethylation (GO:0018023)4.61991428
8translational termination (GO:0006415)4.42888296
9viral transcription (GO:0019083)4.41583724
10maturation of SSU-rRNA (GO:0030490)4.38398390
11ribosomal small subunit assembly (GO:0000028)4.29642715
12nuclear pore complex assembly (GO:0051292)4.23462518
13cytoplasmic mRNA processing body assembly (GO:0033962)4.12285781
14regulation of centriole replication (GO:0046599)4.01861919
15DNA topological change (GO:0006265)3.90023707
16regulation of RNA export from nucleus (GO:0046831)3.86499860
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.82970798
18histone H3-K4 methylation (GO:0051568)3.76305401
19chromatin remodeling at centromere (GO:0031055)3.65739599
20CENP-A containing nucleosome assembly (GO:0034080)3.58304251
21negative regulation of DNA repair (GO:0045738)3.57769753
22positive regulation of histone H3-K4 methylation (GO:0051571)3.55752165
23heterochromatin organization (GO:0070828)3.51624100
24alternative mRNA splicing, via spliceosome (GO:0000380)3.50580946
25nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.50367362
26regulation of centrosome duplication (GO:0010824)3.45840720
27nuclear pore organization (GO:0006999)3.43427961
28kidney morphogenesis (GO:0060993)3.42831051
29protein localization to kinetochore (GO:0034501)3.42793811
30negative regulation of histone methylation (GO:0031061)3.42179623
31neural tube formation (GO:0001841)3.41263207
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.41114901
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.40399990
34regulation of histone H3-K4 methylation (GO:0051569)3.38888039
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38184039
36cellular protein complex disassembly (GO:0043624)3.37438242
37protein localization to chromosome, centromeric region (GO:0071459)3.36827332
38DNA replication-independent nucleosome organization (GO:0034724)3.36713889
39DNA replication-independent nucleosome assembly (GO:0006336)3.36713889
40translational initiation (GO:0006413)3.36090181
41peptidyl-lysine methylation (GO:0018022)3.35770576
42kinetochore assembly (GO:0051382)3.35206389
43translational elongation (GO:0006414)3.33963692
44cotranslational protein targeting to membrane (GO:0006613)3.33666417
45DNA conformation change (GO:0071103)3.32246516
46regulation of centrosome cycle (GO:0046605)3.31458390
47double-strand break repair via nonhomologous end joining (GO:0006303)3.30299911
48non-recombinational repair (GO:0000726)3.30299911
49protein targeting to ER (GO:0045047)3.30014564
50mitotic sister chromatid segregation (GO:0000070)3.24088510
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21264040
52mitotic G2/M transition checkpoint (GO:0044818)3.20654424
53viral life cycle (GO:0019058)3.20574932
54regulation of histone H3-K9 methylation (GO:0051570)3.20018110
55somite development (GO:0061053)3.19327403
56protein complex disassembly (GO:0043241)3.18072403
57regulation of nucleobase-containing compound transport (GO:0032239)3.17798927
58negative regulation of translation, ncRNA-mediated (GO:0040033)3.15711885
59regulation of translation, ncRNA-mediated (GO:0045974)3.15711885
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.15711885
61inner ear receptor cell development (GO:0060119)3.15507531
62histone lysine methylation (GO:0034968)3.10255289
63ribosomal large subunit biogenesis (GO:0042273)3.09982127
64chromatin assembly or disassembly (GO:0006333)3.09887573
65regulation of histone methylation (GO:0031060)3.09066723
66ribonucleoprotein complex biogenesis (GO:0022613)3.08802785
67ATP-dependent chromatin remodeling (GO:0043044)3.07265752
68dosage compensation (GO:0007549)3.07170352
69histone exchange (GO:0043486)3.06943817
70macromolecular complex disassembly (GO:0032984)3.05338112
71centriole replication (GO:0007099)3.05244753
72termination of RNA polymerase II transcription (GO:0006369)3.05151040
73mRNA transport (GO:0051028)3.00573749
74mitotic recombination (GO:0006312)2.99873658
75pore complex assembly (GO:0046931)2.99403840
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.99398671
77interkinetic nuclear migration (GO:0022027)2.99334592
78pre-miRNA processing (GO:0031054)2.98240171
79DNA replication initiation (GO:0006270)2.97165056
80spliceosomal tri-snRNP complex assembly (GO:0000244)2.96903775
81chromatin assembly (GO:0031497)2.96423860
82protein localization to endoplasmic reticulum (GO:0070972)2.96327515
83DNA strand elongation involved in DNA replication (GO:0006271)2.93450668
84DNA replication checkpoint (GO:0000076)2.93152178
85telomere maintenance via recombination (GO:0000722)2.91664008
86formation of translation preinitiation complex (GO:0001731)2.91318781
87positive regulation of cell cycle checkpoint (GO:1901978)2.90844388
88histone H3-K9 methylation (GO:0051567)2.89180754
89mitotic G2 DNA damage checkpoint (GO:0007095)2.89133187
90mRNA catabolic process (GO:0006402)2.88196311
91mitotic nuclear envelope disassembly (GO:0007077)2.86275826
92mRNA stabilization (GO:0048255)2.85797212
93RNA stabilization (GO:0043489)2.85797212
94DNA strand elongation (GO:0022616)2.85359400
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.84073122
96regulation of mRNA splicing, via spliceosome (GO:0048024)2.84035263
97negative regulation of RNA splicing (GO:0033119)2.83297933
98positive regulation of gamma-delta T cell activation (GO:0046645)2.81672289
99positive regulation of histone methylation (GO:0031062)2.77649447
100kinetochore organization (GO:0051383)2.73038616
101DNA unwinding involved in DNA replication (GO:0006268)2.72946164
102activated T cell proliferation (GO:0050798)2.72401483
103retina layer formation (GO:0010842)2.72363442
104glucocorticoid receptor signaling pathway (GO:0042921)2.71149644
105poly(A)+ mRNA export from nucleus (GO:0016973)2.70554957
106mRNA export from nucleus (GO:0006406)2.70541012
107negative regulation of T cell mediated immunity (GO:0002710)2.70343892
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70270747
109histone H2B ubiquitination (GO:0033523)2.70229413
110V(D)J recombination (GO:0033151)2.69397164
111negative regulation of mRNA processing (GO:0050686)2.69346183
112adenine nucleotide transport (GO:0051503)2.66330356
113embryonic camera-type eye morphogenesis (GO:0048596)2.64785626
114positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.64144877
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63242214
116histone methylation (GO:0016571)2.62845210
117regulation of mRNA processing (GO:0050684)2.61519603
118regulation of RNA splicing (GO:0043484)2.61472154
119lateral sprouting from an epithelium (GO:0060601)2.61190181
120positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59849190
121RNA export from nucleus (GO:0006405)2.59304870
122positive regulation of gene expression, epigenetic (GO:0045815)2.59081171
123neural tube development (GO:0021915)2.58312735
124histone H3-K9 modification (GO:0061647)2.56957197
125definitive hemopoiesis (GO:0060216)2.53832008
126mitotic chromosome condensation (GO:0007076)2.52455498
127histone mRNA catabolic process (GO:0071044)2.51767006
128stress granule assembly (GO:0034063)2.50053099
129histone H3-K36 demethylation (GO:0070544)2.48813303
130DNA duplex unwinding (GO:0032508)2.47249912
131sister chromatid segregation (GO:0000819)2.46549978
132sister chromatid cohesion (GO:0007062)2.46231800
133positive regulation of granulocyte differentiation (GO:0030854)2.46092985
134DNA geometric change (GO:0032392)2.45992089
135regulation of mRNA metabolic process (GO:1903311)2.43434937
136positive regulation of histone deacetylation (GO:0031065)2.42511753
137corticosteroid receptor signaling pathway (GO:0031958)2.41956761
138negative regulation of mRNA metabolic process (GO:1903312)2.41663078
139purine ribonucleotide transport (GO:0015868)2.41549084
140histone H3-K9 demethylation (GO:0033169)2.38398432
141histone monoubiquitination (GO:0010390)2.36991569
142histone lysine demethylation (GO:0070076)2.35076469
143meiotic chromosome segregation (GO:0045132)2.34869497
144regulation of mitotic spindle organization (GO:0060236)2.34746138
145regulation of helicase activity (GO:0051095)2.34484897
146anatomical structure arrangement (GO:0048532)2.34182615
147protein targeting to Golgi (GO:0000042)2.32571317
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.31488029
149regulation of chromatin silencing (GO:0031935)2.29995181
150head development (GO:0060322)2.29427627
151regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.28565641
152positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.28565641
153regulation of telomere maintenance (GO:0032204)2.27298944
154regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.26114022
155regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.26082316
156regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.25844591
157positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.25844591
158histone phosphorylation (GO:0016572)2.24359527
159regulation of histone H3-K27 methylation (GO:0061085)2.23616401
160mRNA 3-end processing (GO:0031124)2.21518561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.92388482
2E2F7_22180533_ChIP-Seq_HELA_Human4.90577882
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18118453
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.66614741
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.35283097
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.21986873
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.13792240
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96971586
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.81994832
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70095290
11FUS_26573619_Chip-Seq_HEK293_Human2.55590834
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50579664
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37263017
14GBX2_23144817_ChIP-Seq_PC3_Human2.34170706
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.31509465
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29883615
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17933544
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12485684
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12092271
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01009883
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98948108
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97153579
23EWS_26573619_Chip-Seq_HEK293_Human1.92880041
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91498060
25TAF15_26573619_Chip-Seq_HEK293_Human1.88765684
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88228807
27TP53_16413492_ChIP-PET_HCT116_Human1.87964585
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86410783
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84006847
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82557758
31AR_21572438_ChIP-Seq_LNCaP_Human1.78272451
32TTF2_22483619_ChIP-Seq_HELA_Human1.72987799
33VDR_23849224_ChIP-Seq_CD4+_Human1.72162812
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70313474
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.65274330
36SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65140067
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.64705708
38XRN2_22483619_ChIP-Seq_HELA_Human1.61636056
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59078039
40FOXP3_21729870_ChIP-Seq_TREG_Human1.57952314
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57325813
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54291582
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53009898
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49323923
45* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48286233
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46886587
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46298950
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46090744
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44563916
50KDM5A_27292631_Chip-Seq_BREAST_Human1.42376971
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42117072
52RUNX_20019798_ChIP-Seq_JUKART_Human1.41870463
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41135909
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41135909
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.40443510
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39912838
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38917454
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37111058
59* GABP_17652178_ChIP-ChIP_JURKAT_Human1.35437532
60CIITA_25753668_ChIP-Seq_RAJI_Human1.35079509
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34657277
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34617248
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34351127
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33170027
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31982543
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.31841790
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30629359
68* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30567944
69* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30083850
70TCF4_23295773_ChIP-Seq_U87_Human1.29796325
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.28927686
72* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28741190
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28439366
74STAT3_23295773_ChIP-Seq_U87_Human1.26932498
75GATA1_22025678_ChIP-Seq_K562_Human1.26570008
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.26272327
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.26115123
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25056610
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24016715
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23835285
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23712459
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23051613
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22707614
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22259501
85CHD1_26751641_Chip-Seq_LNCaP_Human1.20879913
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20761850
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19295884
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18954956
89SCL_19346495_ChIP-Seq_HPC-7_Human1.18376438
90ER_23166858_ChIP-Seq_MCF-7_Human1.17617291
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17120669
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15753879
93AR_21909140_ChIP-Seq_LNCAP_Human1.15571724
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14696583
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.13985315
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13797992
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.13582890
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.13412327
99ZNF274_21170338_ChIP-Seq_K562_Hela1.13403834
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.13058941
101P300_19829295_ChIP-Seq_ESCs_Human1.12633845
102* MYB_26560356_Chip-Seq_TH1_Human1.12578465
103SMAD4_21799915_ChIP-Seq_A2780_Human1.11194540
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11175606
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10596990
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.09399598
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08965666
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06994855
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06846708
110* ELK1_19687146_ChIP-ChIP_HELA_Human1.06425837
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06269783
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06013237
113* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05703850
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04222404
115* MYB_26560356_Chip-Seq_TH2_Human1.04005234
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03866928
117P53_22387025_ChIP-Seq_ESCs_Mouse1.03829103
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.03522186
119* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02032591
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.01994809
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01941211
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.01709753
123P300_18555785_Chip-Seq_ESCs_Mouse1.01631574
124DCP1A_22483619_ChIP-Seq_HELA_Human1.01099728
125MYC_18940864_ChIP-ChIP_HL60_Human1.00348368
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99923249
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99923249
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99923249
129* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99392745
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98367520
131* ETS1_20019798_ChIP-Seq_JURKAT_Human0.98321118
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.98302217
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.97863965
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97104873
135IGF1R_20145208_ChIP-Seq_DFB_Human0.96893632
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96630821
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96382591
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96269898
139* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96071919
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95224825
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94992140
142MYC_22102868_ChIP-Seq_BL_Human0.93756608
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93362534
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.92645736
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91232453
146* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90750817
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.90420742
148SOX9_26525672_Chip-Seq_HEART_Mouse0.89806782
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88519382
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.88447891
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87435602
152* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87167257
153EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86291729
154* SPI1_23547873_ChIP-Seq_NB4_Human0.85995990
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85253175
156* GABP_19822575_ChIP-Seq_HepG2_Human0.84516881
157TFEB_21752829_ChIP-Seq_HELA_Human0.79626384
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78010031
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.76157746
160* NCOR1_26117541_ChIP-Seq_K562_Human0.74893106
161STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73539800
162TCF7_22412390_ChIP-Seq_EML_Mouse0.72157547
163VDR_21846776_ChIP-Seq_THP-1_Human0.69396207
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.69051831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.33529711
2MP0003787_abnormal_imprinting4.08908132
3MP0008057_abnormal_DNA_replication3.80090535
4MP0000569_abnormal_digit_pigmentation3.03058225
5MP0009379_abnormal_foot_pigmentation3.01608467
6MP0004957_abnormal_blastocyst_morpholog2.85661782
7MP0003136_yellow_coat_color2.80873672
8MP0003121_genomic_imprinting2.56801899
9MP0005670_abnormal_white_adipose2.24762876
10MP0003283_abnormal_digestive_organ2.13486402
11MP0002938_white_spotting2.11850373
12MP0005076_abnormal_cell_differentiation2.01687133
13MP0000383_abnormal_hair_follicle1.99994185
14MP0000462_abnormal_digestive_system1.95669465
15MP0003300_gastrointestinal_ulcer1.91643644
16MP0000537_abnormal_urethra_morphology1.88463569
17MP0003045_fibrosis1.84554580
18MP0002396_abnormal_hematopoietic_system1.80219044
19MP0000566_synostosis1.77546756
20MP0010307_abnormal_tumor_latency1.68221936
21MP0003937_abnormal_limbs/digits/tail_de1.66718015
22MP0006072_abnormal_retinal_apoptosis1.64905159
23MP0001697_abnormal_embryo_size1.62245837
24MP0010678_abnormal_skin_adnexa1.59226961
25MP0010094_abnormal_chromosome_stability1.57818426
26MP0008058_abnormal_DNA_repair1.53298458
27MP0001730_embryonic_growth_arrest1.53025779
28MP0000428_abnormal_craniofacial_morphol1.51218550
29MP0002928_abnormal_bile_duct1.49737517
30MP0001986_abnormal_taste_sensitivity1.49306065
31MP0008995_early_reproductive_senescence1.49051875
32MP0003950_abnormal_plasma_membrane1.47185579
33MP0008932_abnormal_embryonic_tissue1.43260092
34MP0009703_decreased_birth_body1.42647787
35MP0004808_abnormal_hematopoietic_stem1.39282429
36MP0006292_abnormal_olfactory_placode1.36269507
37MP0000015_abnormal_ear_pigmentation1.36020273
38MP0003111_abnormal_nucleus_morphology1.35387330
39MP0004185_abnormal_adipocyte_glucose1.35301204
40MP0008007_abnormal_cellular_replicative1.35084589
41MP0003123_paternal_imprinting1.33233926
42MP0008877_abnormal_DNA_methylation1.32278435
43MP0006054_spinal_hemorrhage1.32248129
44MP0003943_abnormal_hepatobiliary_system1.30913781
45MP0002009_preneoplasia1.30453207
46MP0004264_abnormal_extraembryonic_tissu1.30014135
47MP0003122_maternal_imprinting1.29872682
48MP0003935_abnormal_craniofacial_develop1.27433507
49MP0002086_abnormal_extraembryonic_tissu1.26760101
50MP0008961_abnormal_basal_metabolism1.25985010
51MP0000703_abnormal_thymus_morphology1.22596400
52MP0002095_abnormal_skin_pigmentation1.21534091
53MP0003077_abnormal_cell_cycle1.21336981
54MP0003693_abnormal_embryo_hatching1.20779733
55MP0003385_abnormal_body_wall1.20297499
56MP0000313_abnormal_cell_death1.19547824
57MP0004197_abnormal_fetal_growth/weight/1.18665065
58MP0002080_prenatal_lethality1.18659511
59MP0000372_irregular_coat_pigmentation1.17687528
60MP0002102_abnormal_ear_morphology1.16847284
61MP0003786_premature_aging1.13456340
62MP0002166_altered_tumor_susceptibility1.13208881
63MP0002089_abnormal_postnatal_growth/wei1.11053598
64MP0000778_abnormal_nervous_system1.10484901
65MP0000465_gastrointestinal_hemorrhage1.08306446
66MP0002075_abnormal_coat/hair_pigmentati1.07526395
67MP0005423_abnormal_somatic_nervous1.04781969
68MP0003763_abnormal_thymus_physiology1.04426192
69MP0005408_hypopigmentation1.02350593
70MP0009672_abnormal_birth_weight1.00165209
71MP0000733_abnormal_muscle_development0.98872607
72MP0003567_abnormal_fetal_cardiomyocyte0.98668194
73MP0000432_abnormal_head_morphology0.98343223
74MP0002019_abnormal_tumor_incidence0.98124328
75MP0000631_abnormal_neuroendocrine_gland0.97782853
76MP0001299_abnormal_eye_distance/0.97624307
77MP0002006_tumorigenesis0.96276829
78MP0002084_abnormal_developmental_patter0.95579697
79MP0005220_abnormal_exocrine_pancreas0.94617687
80MP0009697_abnormal_copulation0.94473019
81MP0003890_abnormal_embryonic-extraembry0.90996014
82MP0001286_abnormal_eye_development0.88970524
83MP0001800_abnormal_humoral_immune0.88967924
84MP0003656_abnormal_erythrocyte_physiolo0.88402164
85MP0002722_abnormal_immune_system0.87650996
86MP0001293_anophthalmia0.87302938
87MP0002697_abnormal_eye_size0.87078519
88MP0000490_abnormal_crypts_of0.86976291
89MP0003755_abnormal_palate_morphology0.86525715
90MP0001186_pigmentation_phenotype0.86503529
91MP0001188_hyperpigmentation0.85607914
92MP0000689_abnormal_spleen_morphology0.85192750
93MP0002085_abnormal_embryonic_tissue0.84737588
94MP0000350_abnormal_cell_proliferation0.82506464
95MP0003984_embryonic_growth_retardation0.82321569
96MP0004742_abnormal_vestibular_system0.82162150
97MP0005551_abnormal_eye_electrophysiolog0.81985672
98MP0005380_embryogenesis_phenotype0.81229999
99MP0001672_abnormal_embryogenesis/_devel0.81229999
100MP0005671_abnormal_response_to0.80706398
101MP0003861_abnormal_nervous_system0.80132065
102MP0002092_abnormal_eye_morphology0.79608958
103MP0000427_abnormal_hair_cycle0.78939770
104MP0002088_abnormal_embryonic_growth/wei0.78871371
105MP0003221_abnormal_cardiomyocyte_apopto0.78867828
106MP0010030_abnormal_orbit_morphology0.78342029
107MP0002116_abnormal_craniofacial_bone0.78276074
108MP0001915_intracranial_hemorrhage0.77312241
109MP0005253_abnormal_eye_physiology0.76785749
110MP0005391_vision/eye_phenotype0.76635863
111MP0002398_abnormal_bone_marrow0.76352945
112MP0001485_abnormal_pinna_reflex0.75939918
113MP0002932_abnormal_joint_morphology0.75920545
114MP0002925_abnormal_cardiovascular_devel0.75324043
115MP0002114_abnormal_axial_skeleton0.74636098
116MP0005174_abnormal_tail_pigmentation0.74598532
117MP0002109_abnormal_limb_morphology0.74516544
118MP0002429_abnormal_blood_cell0.74211218
119MP0002177_abnormal_outer_ear0.73964750
120MP0002877_abnormal_melanocyte_morpholog0.73493843
121MP0002249_abnormal_larynx_morphology0.73243706
122MP0005187_abnormal_penis_morphology0.73043719
123MP0003115_abnormal_respiratory_system0.72962457
124MP0002111_abnormal_tail_morphology0.72657543
125MP0005367_renal/urinary_system_phenotyp0.72389264
126MP0000516_abnormal_urinary_system0.72389264
127MP0005171_absent_coat_pigmentation0.71797042
128MP0009250_abnormal_appendicular_skeleto0.71797039
129MP0002233_abnormal_nose_morphology0.71691033
130MP0002210_abnormal_sex_determination0.71664216
131MP0001873_stomach_inflammation0.71612004
132MP0001851_eye_inflammation0.70736569
133MP0005666_abnormal_adipose_tissue0.70708065
134MP0004270_analgesia0.70448281
135MP0010352_gastrointestinal_tract_polyps0.70148786
136MP0000716_abnormal_immune_system0.69219334
137MP0002160_abnormal_reproductive_system0.66903820
138MP0005621_abnormal_cell_physiology0.66577963
139MP0005075_abnormal_melanosome_morpholog0.66547193
140MP0001145_abnormal_male_reproductive0.66500596
141MP0009115_abnormal_fat_cell0.66066675
142MP0005384_cellular_phenotype0.62865327
143MP0009278_abnormal_bone_marrow0.61739253
144MP0003938_abnormal_ear_development0.61497257
145MP0001929_abnormal_gametogenesis0.61369251
146MP0004381_abnormal_hair_follicle0.61331323
147MP0003936_abnormal_reproductive_system0.61209520

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.97808760
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.72646040
3Volvulus (HP:0002580)4.01946979
4Reticulocytopenia (HP:0001896)3.79366144
511 pairs of ribs (HP:0000878)3.42464565
6Acute myeloid leukemia (HP:0004808)3.40061046
7Abnormality of chromosome stability (HP:0003220)3.39898450
8Abnormality of the fingertips (HP:0001211)3.26526416
9Absent frontal sinuses (HP:0002688)3.06884501
10Papillary thyroid carcinoma (HP:0002895)3.04290959
11Missing ribs (HP:0000921)3.02028002
12Nephroblastoma (Wilms tumor) (HP:0002667)2.96192034
13Embryonal renal neoplasm (HP:0011794)2.81893801
14Acute lymphatic leukemia (HP:0006721)2.78245150
15Overriding aorta (HP:0002623)2.77027038
16Abnormality of the parietal bone (HP:0002696)2.75422141
17Pallor (HP:0000980)2.72754459
18Supernumerary ribs (HP:0005815)2.71164744
19Myelodysplasia (HP:0002863)2.70991637
20Deep philtrum (HP:0002002)2.67191499
21Abnormality of cells of the erythroid lineage (HP:0012130)2.66719643
22Macrocytic anemia (HP:0001972)2.65322908
23Macroorchidism (HP:0000053)2.65301849
24Sandal gap (HP:0001852)2.64670027
25Short 4th metacarpal (HP:0010044)2.63462794
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63462794
27Trigonocephaly (HP:0000243)2.59144120
28Short middle phalanx of the 5th finger (HP:0004220)2.57064922
29Elfin facies (HP:0004428)2.56768802
30Renovascular hypertension (HP:0100817)2.55192433
31Spinal cord lesions (HP:0100561)2.51921728
32Syringomyelia (HP:0003396)2.51921728
33Obsessive-compulsive behavior (HP:0000722)2.49486559
34Abnormality of DNA repair (HP:0003254)2.45731384
35Abnormality of the preputium (HP:0100587)2.44624894
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.44512847
37Meckel diverticulum (HP:0002245)2.42429693
38Increased nuchal translucency (HP:0010880)2.41399720
39Progressive sensorineural hearing impairment (HP:0000408)2.41274402
40Long eyelashes (HP:0000527)2.39606541
41Basal cell carcinoma (HP:0002671)2.38478778
42Narrow palate (HP:0000189)2.37203219
43Hyperacusis (HP:0010780)2.36874163
44Anal stenosis (HP:0002025)2.35551079
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.32589016
46Supernumerary bones of the axial skeleton (HP:0009144)2.32416363
47Chronic hepatic failure (HP:0100626)2.30794552
48Abnormality of the ileum (HP:0001549)2.29113755
49Progressive external ophthalmoplegia (HP:0000590)2.27677929
50Renal duplication (HP:0000075)2.23391772
51Septate vagina (HP:0001153)2.22455392
52Abnormal number of incisors (HP:0011064)2.20833843
53Follicular hyperkeratosis (HP:0007502)2.20284773
54Urethral obstruction (HP:0000796)2.19652042
55Clubbing of toes (HP:0100760)2.17729605
56Abnormality of the 2nd finger (HP:0004100)2.15849883
57Rhabdomyosarcoma (HP:0002859)2.15624168
58Diastasis recti (HP:0001540)2.15260082
59Heterotopia (HP:0002282)2.14457830
60Metaphyseal cupping (HP:0003021)2.11805323
61Abnormality of the columella (HP:0009929)2.11764101
62Broad palm (HP:0001169)2.11080592
63Facial hemangioma (HP:0000329)2.10458907
64Short middle phalanx of finger (HP:0005819)2.09976978
65Aplasia cutis congenita (HP:0001057)2.08287802
66Cafe-au-lait spot (HP:0000957)2.06180550
67Hepatoblastoma (HP:0002884)2.04107900
68Anteriorly placed anus (HP:0001545)2.04062623
69Medulloblastoma (HP:0002885)2.04011923
70Metaphyseal dysplasia (HP:0100255)2.03701321
71Abnormality of the diencephalon (HP:0010662)2.02001118
72Panhypogammaglobulinemia (HP:0003139)2.01029568
73Cystic hygroma (HP:0000476)2.00654339
74Bowel diverticulosis (HP:0005222)2.00431321
75Abnormality of chromosome segregation (HP:0002916)2.00369065
76Sloping forehead (HP:0000340)2.00290626
77Impulsivity (HP:0100710)1.99460540
78Stomach cancer (HP:0012126)1.99249417
79Overlapping toe (HP:0001845)1.98787529
80Abnormality of the frontal sinuses (HP:0002687)1.98481050
81Abnormality of the incisor (HP:0000676)1.97983797
82Abnormality of the nasal septum (HP:0000419)1.97891919
83Deep palmar crease (HP:0006191)1.97692935
84Colon cancer (HP:0003003)1.97186075
85Cutis marmorata (HP:0000965)1.96707626
86Capillary hemangiomas (HP:0005306)1.96328128
87Midline defect of the nose (HP:0004122)1.96195716
88Viral hepatitis (HP:0006562)1.96057095
89T lymphocytopenia (HP:0005403)1.95887608
90Truncal obesity (HP:0001956)1.93872800
91Birth length less than 3rd percentile (HP:0003561)1.92354629
92Lip pit (HP:0100267)1.90276397
93Abnormality of the 4th metacarpal (HP:0010012)1.89684560
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88019802
95High anterior hairline (HP:0009890)1.85726577
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.85185043
97Thyroid carcinoma (HP:0002890)1.85054546
98Short phalanx of the thumb (HP:0009660)1.84991254
99Arteriovenous malformation (HP:0100026)1.84564869
100Aqueductal stenosis (HP:0002410)1.84518521
101Vesicoureteral reflux (HP:0000076)1.84335051
102Vertebral arch anomaly (HP:0008438)1.84035886
103Proximal placement of thumb (HP:0009623)1.83999431
104Patellar dislocation (HP:0002999)1.83893077
105Blepharitis (HP:0000498)1.83445594
106Hypoplasia of the maxilla (HP:0000327)1.82840330
107Flat cornea (HP:0007720)1.82249526
108Triphalangeal thumb (HP:0001199)1.81779450
109Abnormality of the 1st metacarpal (HP:0010009)1.81446809
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80783601
111Pseudobulbar signs (HP:0002200)1.79928143
112Ectopic kidney (HP:0000086)1.79658788
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.79195931
114Short 5th finger (HP:0009237)1.79166123
115Colitis (HP:0002583)1.78520880
116Occipital encephalocele (HP:0002085)1.78019677
117Abnormality of the carotid arteries (HP:0005344)1.77989129
118Thyroiditis (HP:0100646)1.77667824
119Prominent nose (HP:0000448)1.77312575
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76718428
121Asymmetry of the thorax (HP:0001555)1.76567587
122Low anterior hairline (HP:0000294)1.76219506
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.75535316
124Long nose (HP:0003189)1.75531863
125Abnormal hair whorl (HP:0010721)1.74464334
126Deviation of the thumb (HP:0009603)1.73136600
127Smooth philtrum (HP:0000319)1.72216454
128Ankyloglossia (HP:0010296)1.71983699
129Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.71648163
130Duodenal stenosis (HP:0100867)1.71498625
131Small intestinal stenosis (HP:0012848)1.71498625
132Recurrent viral infections (HP:0004429)1.71023977
133Thick eyebrow (HP:0000574)1.68577692
134Dislocated radial head (HP:0003083)1.67925975
135Limited elbow extension (HP:0001377)1.67536194
136Highly arched eyebrow (HP:0002553)1.67529828
137Abnormality of the ischium (HP:0003174)1.67190518
138Atresia of the external auditory canal (HP:0000413)1.67097429
139Ectropion (HP:0000656)1.67017116
140Abnormality of T cell number (HP:0011839)1.66709260
141Embryonal neoplasm (HP:0002898)1.66499130
142Gastrointestinal atresia (HP:0002589)1.65923346
143Increased number of teeth (HP:0011069)1.64882030
144Alopecia of scalp (HP:0002293)1.63796907
145Intestinal malrotation (HP:0002566)1.63773043
146Abnormality of oral frenula (HP:0000190)1.63580555
147Tented upper lip vermilion (HP:0010804)1.63387817
148Stenosis of the external auditory canal (HP:0000402)1.63336303
149Neoplasm of the oral cavity (HP:0100649)1.63152109
150Progressive hearing impairment (HP:0001730)1.63000047
151Bell-shaped thorax (HP:0001591)1.62797187
152Acanthocytosis (HP:0001927)1.62270775
153Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62267269
154Abnormality of cochlea (HP:0000375)1.60875468
155Agammaglobulinemia (HP:0004432)1.60282286
156Oligodactyly (hands) (HP:0001180)1.59256540
157Wide intermamillary distance (HP:0006610)1.58724181
158Short chin (HP:0000331)1.58008522
159Anal atresia (HP:0002023)1.57076900
160Tubulointerstitial nephritis (HP:0001970)1.57018057
161Combined immunodeficiency (HP:0005387)1.56737595
162Protruding tongue (HP:0010808)1.56172157
163Hypoplastic ischia (HP:0003175)1.56142432
164Multiple enchondromatosis (HP:0005701)1.56005064
165Neoplasm of the adrenal cortex (HP:0100641)1.55415506
166Intestinal atresia (HP:0011100)1.55176022
167Subacute progressive viral hepatitis (HP:0006572)1.54544527
168Hypopigmentation of the fundus (HP:0007894)1.53758623
169Abnormality of the thymus (HP:0000777)1.53380359
170Abnormality of the radial head (HP:0003995)1.53210851
171Ureteral obstruction (HP:0006000)1.52886737
172Skin tags (HP:0010609)1.52662574
173Relative macrocephaly (HP:0004482)1.52472645
174Neoplasm of striated muscle (HP:0009728)1.51302410
175Severe combined immunodeficiency (HP:0004430)1.50288048
176Abnormality of the renal cortex (HP:0011035)1.49284173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.96840794
2TNIK6.07448940
3MKNK15.53778401
4BRD42.20301374
5BRSK22.08447942
6PLK42.02622946
7WEE11.97569343
8TAF11.95055141
9FGFR21.95003863
10CDC71.85579780
11CDK121.82884421
12CAMK1G1.72758685
13RIPK11.63864575
14TYRO31.60004802
15SRPK11.58554632
16TSSK61.54137820
17PNCK1.44580436
18EEF2K1.36691133
19CAMK1D1.28656711
20ZAK1.22015059
21FGFR41.19192454
22NUAK11.17238711
23PIK3CA1.15470959
24MAP3K61.11085142
25ATR1.09251598
26MAP3K141.08901127
27TAOK31.08829419
28TTK1.04043356
29LATS11.03289462
30EIF2AK30.99404372
31AKT30.97983063
32EIF2AK10.92985868
33CDK70.92938783
34FRK0.92560097
35CLK10.92440421
36BRSK10.91975761
37WNK10.91703603
38RPS6KA40.91528971
39SIK20.91443578
40ICK0.89207401
41FGFR10.89012072
42MAPK130.88765271
43WNK40.86934527
44* ATM0.86800035
45ITK0.85323938
46MAP3K40.84723376
47INSRR0.84236878
48CSNK1A1L0.83451295
49TXK0.82953911
50CDK30.82497329
51EIF2AK20.82208236
52CDK90.81766016
53MARK30.81621532
54PLK10.80191142
55CHEK10.79317191
56SCYL20.76337680
57STK100.73985665
58CDK60.73784430
59MAP4K10.71078794
60PASK0.70159085
61IRAK30.69403443
62DMPK0.67166903
63RPS6KB10.66851317
64MAP3K100.66321258
65FGFR30.64772331
66PTK60.63941048
67MAPK150.63665193
68ERBB30.62999630
69STK40.62952139
70CSNK1D0.62390911
71TEC0.62208242
72NEK20.62005969
73* MAPK140.59993832
74MAP3K70.59897342
75* CDK10.59487180
76BMPR20.59098226
77CSNK2A20.58500062
78PAK20.58237683
79MAP3K20.58112516
80PRKCH0.58107242
81SMG10.58022678
82CHEK20.57448129
83MTOR0.57163865
84SGK30.56982196
85MARK20.56684676
86* CSNK1E0.56273446
87* PRKDC0.54940064
88RIPK40.53948259
89IKBKE0.53795135
90ALK0.53084701
91JAK30.52553692
92MELK0.52453262
93PRPF4B0.51421338
94CDC42BPA0.51203472
95* GSK3B0.50400185
96NTRK20.50333768
97SIK10.49973360
98HIPK20.49653470
99* CDK20.49608191
100PIM10.49327011
101MST40.49175117
102RPS6KB20.48054132
103PDGFRB0.47814995
104PLK30.47459442
105NEK60.44875516
106DYRK1A0.44688404
107FES0.44424269
108STK110.43684366
109LCK0.43462587
110STK30.42701019
111BTK0.41623947
112* SGK10.41486457
113YES10.41198001
114STK38L0.40966469
115MAPK100.40889128
116MAP3K130.40778858
117NEK10.40770845
118PKN10.40365141
119VRK10.40257272
120PDK20.40254738
121AURKB0.40208349
122PRKAA20.39527365
123IRAK40.39495371
124PKN20.39389267
125MAPK80.39311815
126STK240.38985453
127PRKCQ0.38535224
128GRK10.38151210
129NTRK30.37939840
130JAK10.36597075
131NLK0.36268698
132PRKCB0.34102004
133AKT10.33797523
134SGK20.33290875
135TRPM70.32743327
136MAPK10.31682516
137RPS6KA50.31333064
138MAP3K80.30570013
139CDK40.30273470

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.42362109
2DNA replication_Homo sapiens_hsa030303.06078184
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67818672
4Lysine degradation_Homo sapiens_hsa003102.20988560
5Nucleotide excision repair_Homo sapiens_hsa034202.10678084
6Primary immunodeficiency_Homo sapiens_hsa053401.99948195
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84773685
8Basal transcription factors_Homo sapiens_hsa030221.81994600
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72997525
10Spliceosome_Homo sapiens_hsa030401.72559444
11mRNA surveillance pathway_Homo sapiens_hsa030151.69610378
12Non-homologous end-joining_Homo sapiens_hsa034501.67571850
13Thyroid cancer_Homo sapiens_hsa052161.60037291
14Systemic lupus erythematosus_Homo sapiens_hsa053221.57683275
15Fanconi anemia pathway_Homo sapiens_hsa034601.52229143
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38638082
17T cell receptor signaling pathway_Homo sapiens_hsa046601.38526239
18MicroRNAs in cancer_Homo sapiens_hsa052061.37562956
19Acute myeloid leukemia_Homo sapiens_hsa052211.37434631
20Prostate cancer_Homo sapiens_hsa052151.34370580
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30689043
22mTOR signaling pathway_Homo sapiens_hsa041501.22868591
23Small cell lung cancer_Homo sapiens_hsa052221.21840165
24B cell receptor signaling pathway_Homo sapiens_hsa046621.20675925
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20445996
26Base excision repair_Homo sapiens_hsa034101.19915132
27RNA degradation_Homo sapiens_hsa030181.18341987
28RNA transport_Homo sapiens_hsa030131.17717145
29Chronic myeloid leukemia_Homo sapiens_hsa052201.15818428
30Basal cell carcinoma_Homo sapiens_hsa052171.15423905
31Notch signaling pathway_Homo sapiens_hsa043301.12566879
32Alcoholism_Homo sapiens_hsa050341.11429187
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.10294024
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10113993
35Herpes simplex infection_Homo sapiens_hsa051681.09649749
36Epstein-Barr virus infection_Homo sapiens_hsa051691.08486522
37Wnt signaling pathway_Homo sapiens_hsa043101.06405932
38Hematopoietic cell lineage_Homo sapiens_hsa046401.05756287
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05587521
40Taste transduction_Homo sapiens_hsa047421.03439591
41Cell cycle_Homo sapiens_hsa041101.03124074
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.02854094
43p53 signaling pathway_Homo sapiens_hsa041151.01075661
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00180238
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98867361
46Circadian rhythm_Homo sapiens_hsa047100.98381461
47RNA polymerase_Homo sapiens_hsa030200.98263861
48Viral carcinogenesis_Homo sapiens_hsa052030.97054326
49Colorectal cancer_Homo sapiens_hsa052100.97038108
50Insulin secretion_Homo sapiens_hsa049110.96212316
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95780386
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95175695
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94302600
54Long-term potentiation_Homo sapiens_hsa047200.92196820
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91678364
56Type II diabetes mellitus_Homo sapiens_hsa049300.91175798
57Platelet activation_Homo sapiens_hsa046110.91023660
58HTLV-I infection_Homo sapiens_hsa051660.90754453
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90162894
60Autoimmune thyroid disease_Homo sapiens_hsa053200.89401279
61Glutamatergic synapse_Homo sapiens_hsa047240.89383941
62Prolactin signaling pathway_Homo sapiens_hsa049170.88999386
63Hepatitis B_Homo sapiens_hsa051610.88979723
64Non-small cell lung cancer_Homo sapiens_hsa052230.88034392
65ECM-receptor interaction_Homo sapiens_hsa045120.87566806
66Pancreatic cancer_Homo sapiens_hsa052120.87413724
67Estrogen signaling pathway_Homo sapiens_hsa049150.86957602
68Morphine addiction_Homo sapiens_hsa050320.85666376
69Mismatch repair_Homo sapiens_hsa034300.84522724
70Axon guidance_Homo sapiens_hsa043600.84429497
71Melanoma_Homo sapiens_hsa052180.84197909
72One carbon pool by folate_Homo sapiens_hsa006700.83007859
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82832580
74Pathways in cancer_Homo sapiens_hsa052000.82675933
75Measles_Homo sapiens_hsa051620.81314422
76Dorso-ventral axis formation_Homo sapiens_hsa043200.80917618
77Circadian entrainment_Homo sapiens_hsa047130.80398442
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80128520
79Adherens junction_Homo sapiens_hsa045200.80122911
80Homologous recombination_Homo sapiens_hsa034400.79804611
81Viral myocarditis_Homo sapiens_hsa054160.79719907
82ErbB signaling pathway_Homo sapiens_hsa040120.79501927
83Endometrial cancer_Homo sapiens_hsa052130.77866001
84MAPK signaling pathway_Homo sapiens_hsa040100.77807270
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77565744
86Hedgehog signaling pathway_Homo sapiens_hsa043400.77279652
87Phototransduction_Homo sapiens_hsa047440.77274694
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77107446
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76963086
90TGF-beta signaling pathway_Homo sapiens_hsa043500.76958915
91Glioma_Homo sapiens_hsa052140.76677101
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76047204
93Inositol phosphate metabolism_Homo sapiens_hsa005620.76014686
94Dilated cardiomyopathy_Homo sapiens_hsa054140.75430209
95Cocaine addiction_Homo sapiens_hsa050300.75338546
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74922938
97Influenza A_Homo sapiens_hsa051640.74223658
98Cholinergic synapse_Homo sapiens_hsa047250.73763697
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73491813
100Melanogenesis_Homo sapiens_hsa049160.71929371
101Thyroid hormone synthesis_Homo sapiens_hsa049180.71205166
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70979042
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69936773
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69387806
105Antigen processing and presentation_Homo sapiens_hsa046120.68923060
106Nicotine addiction_Homo sapiens_hsa050330.67369441
107Proteoglycans in cancer_Homo sapiens_hsa052050.67227838
108Choline metabolism in cancer_Homo sapiens_hsa052310.67045523
109FoxO signaling pathway_Homo sapiens_hsa040680.65518672
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64643752
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64613871
112Focal adhesion_Homo sapiens_hsa045100.64094693
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.63784833
114Long-term depression_Homo sapiens_hsa047300.63256122
115Renal cell carcinoma_Homo sapiens_hsa052110.63145932
116Salivary secretion_Homo sapiens_hsa049700.62709772
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.62630479
118Amphetamine addiction_Homo sapiens_hsa050310.62539252
119Pancreatic secretion_Homo sapiens_hsa049720.62367927
120Hepatitis C_Homo sapiens_hsa051600.59033574
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56006879
122Apoptosis_Homo sapiens_hsa042100.52962552
123Protein export_Homo sapiens_hsa030600.51493363
124Pyrimidine metabolism_Homo sapiens_hsa002400.50865516
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.50357275
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50301925
127Asthma_Homo sapiens_hsa053100.49139317
128Toxoplasmosis_Homo sapiens_hsa051450.47715535
129Leishmaniasis_Homo sapiens_hsa051400.47552204
130TNF signaling pathway_Homo sapiens_hsa046680.47547580
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43985342
132Oocyte meiosis_Homo sapiens_hsa041140.43563553
133VEGF signaling pathway_Homo sapiens_hsa043700.40598443
134Purine metabolism_Homo sapiens_hsa002300.39953040
135Insulin resistance_Homo sapiens_hsa049310.39061387
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38988885
137Allograft rejection_Homo sapiens_hsa053300.38749872
138HIF-1 signaling pathway_Homo sapiens_hsa040660.38630259
139Hippo signaling pathway_Homo sapiens_hsa043900.37521373
140Graft-versus-host disease_Homo sapiens_hsa053320.35640038

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