PRPF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.69686644
2DNA replication initiation (GO:0006270)4.66775512
3DNA strand elongation involved in DNA replication (GO:0006271)4.65938866
4DNA strand elongation (GO:0022616)4.47564617
5telomere maintenance via semi-conservative replication (GO:0032201)4.42588518
6DNA replication checkpoint (GO:0000076)4.41498976
7IMP biosynthetic process (GO:0006188)4.25523307
8nucleobase biosynthetic process (GO:0046112)4.24397760
9nuclear pore organization (GO:0006999)4.24235038
10chromatin remodeling at centromere (GO:0031055)4.16239133
11kinetochore organization (GO:0051383)4.15240932
12CENP-A containing nucleosome assembly (GO:0034080)4.14709591
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.10049207
14mitotic metaphase plate congression (GO:0007080)4.09207298
15protein localization to kinetochore (GO:0034501)4.06964759
16nuclear pore complex assembly (GO:0051292)4.05636811
17telomere maintenance via recombination (GO:0000722)3.97415920
18ribosomal small subunit assembly (GO:0000028)3.92249885
19establishment of viral latency (GO:0019043)3.87992407
20mitotic recombination (GO:0006312)3.87160979
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.85152623
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.85152623
23DNA replication-dependent nucleosome assembly (GO:0006335)3.81042456
24DNA replication-dependent nucleosome organization (GO:0034723)3.81042456
25DNA replication-independent nucleosome organization (GO:0034724)3.76627014
26DNA replication-independent nucleosome assembly (GO:0006336)3.76627014
27kinetochore assembly (GO:0051382)3.75861567
28metaphase plate congression (GO:0051310)3.75026946
29IMP metabolic process (GO:0046040)3.73827965
30mitotic nuclear envelope disassembly (GO:0007077)3.73027841
31purine nucleobase biosynthetic process (GO:0009113)3.72137272
32maturation of SSU-rRNA (GO:0030490)3.69353271
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69158902
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68028214
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67877673
36viral mRNA export from host cell nucleus (GO:0046784)3.65519292
37telomere maintenance via telomere lengthening (GO:0010833)3.63195458
38regulation of helicase activity (GO:0051095)3.63176371
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60722011
40formation of translation preinitiation complex (GO:0001731)3.60362345
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.60105111
42folic acid-containing compound biosynthetic process (GO:0009396)3.57702334
43proteasome assembly (GO:0043248)3.56841879
44protein localization to chromosome, centromeric region (GO:0071459)3.55033675
45regulation of centriole replication (GO:0046599)3.53661879
46DNA deamination (GO:0045006)3.51816421
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.50991885
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48107439
49negative regulation of ligase activity (GO:0051352)3.46534815
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46534815
51ribosome biogenesis (GO:0042254)3.44452823
52pore complex assembly (GO:0046931)3.41534015
53meiotic chromosome segregation (GO:0045132)3.41030474
54establishment of chromosome localization (GO:0051303)3.39692694
55nuclear envelope disassembly (GO:0051081)3.39158877
56membrane disassembly (GO:0030397)3.39158877
57histone exchange (GO:0043486)3.38463825
58non-recombinational repair (GO:0000726)3.35787078
59double-strand break repair via nonhomologous end joining (GO:0006303)3.35787078
60mitotic chromosome condensation (GO:0007076)3.31950067
61mismatch repair (GO:0006298)3.27426699
62mitotic sister chromatid segregation (GO:0000070)3.26194723
63DNA ligation (GO:0006266)3.25179155
64rRNA modification (GO:0000154)3.25097020
65regulation of translational termination (GO:0006449)3.24444908
66DNA duplex unwinding (GO:0032508)3.24148452
67DNA geometric change (GO:0032392)3.22837471
68ribonucleoprotein complex biogenesis (GO:0022613)3.22757129
69attachment of spindle microtubules to kinetochore (GO:0008608)3.22588138
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.21574141
71regulation of translational fidelity (GO:0006450)3.21166298
72ribosome assembly (GO:0042255)3.19604216
73regulation of spindle organization (GO:0090224)3.19232799
74mitochondrial RNA metabolic process (GO:0000959)3.18046665
75ribosomal large subunit biogenesis (GO:0042273)3.17820423
76regulation of chromosome segregation (GO:0051983)3.16852720
77mitotic sister chromatid cohesion (GO:0007064)3.16766929
78tRNA aminoacylation for protein translation (GO:0006418)3.16706634
79spliceosomal snRNP assembly (GO:0000387)3.15994402
80nucleobase-containing small molecule interconversion (GO:0015949)3.15662258
81telomere organization (GO:0032200)3.10246624
82DNA topological change (GO:0006265)3.10206193
83amino acid activation (GO:0043038)3.09957177
84tRNA aminoacylation (GO:0043039)3.09957177
85telomere maintenance (GO:0000723)3.09822437
86maturation of 5.8S rRNA (GO:0000460)3.06455766
87sister chromatid segregation (GO:0000819)3.06348866
88rRNA processing (GO:0006364)3.05665219
89protein K6-linked ubiquitination (GO:0085020)3.05590404
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05338530
91transcription-coupled nucleotide-excision repair (GO:0006283)3.05259892
92chromatin assembly or disassembly (GO:0006333)3.04493267
93G1/S transition of mitotic cell cycle (GO:0000082)3.03687909
94cell cycle G1/S phase transition (GO:0044843)3.03687909
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02877215
96rRNA methylation (GO:0031167)3.01583171
97positive regulation of chromosome segregation (GO:0051984)3.00970763
98regulation of histone H3-K9 methylation (GO:0051570)3.00453381
99chromosome condensation (GO:0030261)2.99080010
100spindle checkpoint (GO:0031577)2.98951988
101regulation of centrosome cycle (GO:0046605)2.98621101
102rRNA metabolic process (GO:0016072)2.96277939
103regulation of sister chromatid cohesion (GO:0007063)2.95936430
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.95380119
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95380119
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95380119
107negative regulation of sister chromatid segregation (GO:0033046)2.95380119
108negative regulation of chromosome segregation (GO:0051985)2.95371050
109DNA replication (GO:0006260)2.94878666
110spindle assembly checkpoint (GO:0071173)2.94370730
111chromosome segregation (GO:0007059)2.93632990
112establishment of integrated proviral latency (GO:0075713)2.93139966
113positive regulation of ligase activity (GO:0051351)2.92950505
114mitotic cell cycle (GO:0000278)2.92533579
115spliceosomal complex assembly (GO:0000245)2.92426031
116pseudouridine synthesis (GO:0001522)2.92062941
117intra-S DNA damage checkpoint (GO:0031573)2.91416951
118* RNA splicing, via transesterification reactions (GO:0000375)2.89714208
119postreplication repair (GO:0006301)2.89223427
120ATP-dependent chromatin remodeling (GO:0043044)2.89032765
121mitotic spindle assembly checkpoint (GO:0007094)2.88626023
122* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87316673
123* mRNA splicing, via spliceosome (GO:0000398)2.87316673
124snRNA processing (GO:0016180)2.85153061
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84923207
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84177312
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84130957
128mitotic spindle checkpoint (GO:0071174)2.83331242
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82866206
130viral transcription (GO:0019083)2.82592952
131translational termination (GO:0006415)2.82407257
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82256279
133translesion synthesis (GO:0019985)2.80829573
134regulation of telomere maintenance via telomerase (GO:0032210)2.80585248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.92648895
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.20595086
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.17068403
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13713543
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40851173
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14236158
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99146849
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.93894691
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88828445
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84689966
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64986549
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.61807054
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58880483
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58536860
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.50234505
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39930248
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37408688
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36598885
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.32393426
20VDR_23849224_ChIP-Seq_CD4+_Human2.25607951
21XRN2_22483619_ChIP-Seq_HELA_Human2.24652654
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18500199
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17949159
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.16656108
25AR_21909140_ChIP-Seq_LNCAP_Human2.16018304
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15930873
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14281386
28FOXP3_21729870_ChIP-Seq_TREG_Human2.13616053
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94197122
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90589946
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89661519
32DCP1A_22483619_ChIP-Seq_HELA_Human1.86244118
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84366105
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83163584
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79318659
36* TTF2_22483619_ChIP-Seq_HELA_Human1.79048013
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78571401
38* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78354827
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77977114
40CIITA_25753668_ChIP-Seq_RAJI_Human1.77960556
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77659925
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.76895452
43* GABP_19822575_ChIP-Seq_HepG2_Human1.74078910
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.72595775
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70768053
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67635935
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65750612
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52937608
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51408960
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49810574
51KDM5A_27292631_Chip-Seq_BREAST_Human1.47835864
52MYC_22102868_ChIP-Seq_BL_Human1.47012196
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.44041444
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39851981
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39242077
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38825006
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36806995
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.30056168
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29632828
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29054218
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28548230
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27685968
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.26984618
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25541522
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24744449
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24735860
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21230110
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20433266
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.20130930
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16332289
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14852380
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11583060
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08958695
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.08527184
75* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07576802
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06111608
77MYC_18940864_ChIP-ChIP_HL60_Human1.04979449
78* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04975542
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04899798
80TFEB_21752829_ChIP-Seq_HELA_Human1.02799051
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02360883
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02062706
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00538912
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99150417
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98742117
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97397237
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96973159
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96402008
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95134395
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95118537
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93024094
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92291087
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90232444
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.89044158
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88003799
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87162669
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87028869
98ZNF263_19887448_ChIP-Seq_K562_Human0.86275596
99CHD1_26751641_Chip-Seq_LNCaP_Human0.84540390
100* SPI1_23547873_ChIP-Seq_NB4_Human0.83554045
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83308810
102* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82087920
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.81048814
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79376250
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79323303
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79296662
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79267162
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79267162
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79267162
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78128502
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75837837
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74884508
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73699748
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73234899
115TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72226531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39037840
2MP0010094_abnormal_chromosome_stability4.86676742
3MP0008057_abnormal_DNA_replication4.82558784
4MP0003111_abnormal_nucleus_morphology4.28974972
5MP0004957_abnormal_blastocyst_morpholog4.07307602
6MP0003077_abnormal_cell_cycle3.92116761
7MP0008058_abnormal_DNA_repair3.75952862
8MP0008007_abnormal_cellular_replicative3.08635921
9MP0008932_abnormal_embryonic_tissue2.57670427
10MP0002396_abnormal_hematopoietic_system2.33797366
11MP0008877_abnormal_DNA_methylation2.30960568
12MP0001730_embryonic_growth_arrest2.17756209
13MP0000350_abnormal_cell_proliferation2.17171814
14MP0003123_paternal_imprinting2.08532947
15MP0003786_premature_aging1.89296201
16MP0010352_gastrointestinal_tract_polyps1.85498105
17MP0006292_abnormal_olfactory_placode1.85136172
18MP0010307_abnormal_tumor_latency1.81845655
19MP0003950_abnormal_plasma_membrane1.81300857
20MP0001672_abnormal_embryogenesis/_devel1.70861088
21MP0005380_embryogenesis_phenotype1.70861088
22MP0001697_abnormal_embryo_size1.64878791
23MP0006035_abnormal_mitochondrial_morpho1.62497692
24MP0003121_genomic_imprinting1.56611056
25MP0001293_anophthalmia1.56540906
26MP0003984_embryonic_growth_retardation1.55984834
27MP0003763_abnormal_thymus_physiology1.53364242
28MP0002085_abnormal_embryonic_tissue1.52620960
29MP0002088_abnormal_embryonic_growth/wei1.51886098
30MP0000358_abnormal_cell_content/1.51220726
31MP0003890_abnormal_embryonic-extraembry1.51040696
32MP0000313_abnormal_cell_death1.47851985
33MP0004808_abnormal_hematopoietic_stem1.47282956
34MP0002080_prenatal_lethality1.45216820
35MP0000537_abnormal_urethra_morphology1.44940674
36MP0000490_abnormal_crypts_of1.44920777
37MP0010234_abnormal_vibrissa_follicle1.43022725
38MP0003567_abnormal_fetal_cardiomyocyte1.40376170
39MP0002084_abnormal_developmental_patter1.39064581
40MP0001346_abnormal_lacrimal_gland1.37540992
41MP0004197_abnormal_fetal_growth/weight/1.36660654
42MP0002086_abnormal_extraembryonic_tissu1.33498434
43MP0009333_abnormal_splenocyte_physiolog1.32426677
44MP0004233_abnormal_muscle_weight1.31019626
45MP0002019_abnormal_tumor_incidence1.30334069
46MP0002210_abnormal_sex_determination1.25105625
47MP0003221_abnormal_cardiomyocyte_apopto1.24392404
48MP0005501_abnormal_skin_physiology1.24228655
49MP0000703_abnormal_thymus_morphology1.18600471
50MP0000516_abnormal_urinary_system1.16760438
51MP0005367_renal/urinary_system_phenotyp1.16760438
52MP0006036_abnormal_mitochondrial_physio1.13020588
53MP0004185_abnormal_adipocyte_glucose1.12388062
54MP0001145_abnormal_male_reproductive1.10282527
55MP0002938_white_spotting1.09243243
56MP0002398_abnormal_bone_marrow1.08209658
57MP0003718_maternal_effect1.07675622
58MP0001661_extended_life_span1.07589376
59MP0010030_abnormal_orbit_morphology1.05305022
60MP0004133_heterotaxia1.04246203
61MP0005408_hypopigmentation1.01555891
62MP0003315_abnormal_perineum_morphology0.99221539
63MP0009672_abnormal_birth_weight0.98656558
64MP0005076_abnormal_cell_differentiation0.97262718
65MP0002160_abnormal_reproductive_system0.95899284
66MP0009053_abnormal_anal_canal0.94856837
67MP0001216_abnormal_epidermal_layer0.94715771
68MP0003806_abnormal_nucleotide_metabolis0.93835193
69MP0000653_abnormal_sex_gland0.92548859
70MP0001929_abnormal_gametogenesis0.92546092
71MP0002722_abnormal_immune_system0.92115083
72MP0003136_yellow_coat_color0.91407007
73MP0003941_abnormal_skin_development0.90819903
74MP0001243_abnormal_dermal_layer0.89934002
75MP0003937_abnormal_limbs/digits/tail_de0.89757549
76MP0003119_abnormal_digestive_system0.88213544
77MP0002060_abnormal_skin_morphology0.86056164
78MP0001286_abnormal_eye_development0.85023038
79MP0009703_decreased_birth_body0.84998759
80MP0001119_abnormal_female_reproductive0.84939536
81MP0002796_impaired_skin_barrier0.83760989
82MP0000689_abnormal_spleen_morphology0.83039068
83MP0001727_abnormal_embryo_implantation0.82521111
84MP0000627_abnormal_mammary_gland0.80960751
85MP0008789_abnormal_olfactory_epithelium0.79732841
86MP0005389_reproductive_system_phenotype0.79685884
87MP0002429_abnormal_blood_cell0.79194876
88MP0001881_abnormal_mammary_gland0.79014295
89MP0002095_abnormal_skin_pigmentation0.78739524
90MP0005075_abnormal_melanosome_morpholog0.78025040
91MP0001853_heart_inflammation0.75782254
92MP0000647_abnormal_sebaceous_gland0.75052718
93MP0000372_irregular_coat_pigmentation0.73025195
94MP0005397_hematopoietic_system_phenotyp0.72879089
95MP0001545_abnormal_hematopoietic_system0.72879089
96MP0000716_abnormal_immune_system0.72402276
97MP0002111_abnormal_tail_morphology0.72211625
98MP0009697_abnormal_copulation0.72107955
99MP0005671_abnormal_response_to0.71315368
100MP0010678_abnormal_skin_adnexa0.71040537
101MP0000566_synostosis0.70970915
102MP0002098_abnormal_vibrissa_morphology0.70945180
103MP0002092_abnormal_eye_morphology0.70538071
104MP0002132_abnormal_respiratory_system0.70419020
105MP0001919_abnormal_reproductive_system0.69711329
106MP0000377_abnormal_hair_follicle0.69234094
107MP0000858_altered_metastatic_potential0.67926531
108MP0005384_cellular_phenotype0.67216354
109MP0004264_abnormal_extraembryonic_tissu0.67147498
110MP0000762_abnormal_tongue_morphology0.66626285
111MP0002006_tumorigenesis0.65218829
112MP0003186_abnormal_redox_activity0.64890091
113MP0000579_abnormal_nail_morphology0.64172892
114MP0003943_abnormal_hepatobiliary_system0.63994097
115MP0000432_abnormal_head_morphology0.63924894
116MP0002233_abnormal_nose_morphology0.63463684
117MP0001348_abnormal_lacrimal_gland0.63174342
118MP0005621_abnormal_cell_physiology0.63074428
119MP0010771_integument_phenotype0.62339649
120MP0001186_pigmentation_phenotype0.61726608
121MP0000678_abnormal_parathyroid_gland0.61258248
122MP0002009_preneoplasia0.60617343
123MP0000428_abnormal_craniofacial_morphol0.60594241
124MP0002163_abnormal_gland_morphology0.60434054
125MP0002234_abnormal_pharynx_morphology0.60349404
126MP0002277_abnormal_respiratory_mucosa0.60214627
127MP0003787_abnormal_imprinting0.60069580
128MP0001529_abnormal_vocalization0.59668419
129MP0001800_abnormal_humoral_immune0.59384649
130MP0002075_abnormal_coat/hair_pigmentati0.59379931
131MP0002877_abnormal_melanocyte_morpholog0.59369161
132MP0002697_abnormal_eye_size0.58467431
133MP0003566_abnormal_cell_adhesion0.58355348
134MP0001188_hyperpigmentation0.57389370
135MP0005197_abnormal_uvea_morphology0.57221629
136MP0003699_abnormal_female_reproductive0.56908064
137MP0003705_abnormal_hypodermis_morpholog0.55711603
138MP0002653_abnormal_ependyma_morphology0.55393460
139MP0003935_abnormal_craniofacial_develop0.54514624

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13380943
2Chromsome breakage (HP:0040012)4.31544182
3Microvesicular hepatic steatosis (HP:0001414)4.24053829
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12782811
5Reticulocytopenia (HP:0001896)3.76609326
6Colon cancer (HP:0003003)3.71929376
7Aplastic anemia (HP:0001915)3.57531837
8Abnormality of chromosome stability (HP:0003220)3.57504080
9Meckel diverticulum (HP:0002245)3.51371858
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.44503837
11Abnormality of glycolysis (HP:0004366)3.42322957
12Medulloblastoma (HP:0002885)3.41888626
13Breast hypoplasia (HP:0003187)3.41799707
14Abnormality of the preputium (HP:0100587)3.41565543
15Abnormality of the ileum (HP:0001549)3.33465970
16Increased serum pyruvate (HP:0003542)3.32727179
17Patellar aplasia (HP:0006443)3.32009036
18Degeneration of anterior horn cells (HP:0002398)3.19383447
19Abnormality of the anterior horn cell (HP:0006802)3.19383447
2011 pairs of ribs (HP:0000878)3.18727618
21Selective tooth agenesis (HP:0001592)3.17140142
22Ependymoma (HP:0002888)3.16153158
23Progressive muscle weakness (HP:0003323)3.07762557
24Aplasia/Hypoplasia of the patella (HP:0006498)3.05463480
25Oral leukoplakia (HP:0002745)3.05178503
26Ectopic kidney (HP:0000086)2.95003966
27Myelodysplasia (HP:0002863)2.87690137
28Agnosia (HP:0010524)2.84107308
29Small intestinal stenosis (HP:0012848)2.80126152
30Duodenal stenosis (HP:0100867)2.80126152
31Abnormality of cells of the erythroid lineage (HP:0012130)2.77265067
32Abnormality of the labia minora (HP:0012880)2.70957807
33Abnormal number of erythroid precursors (HP:0012131)2.69570249
34Absent radius (HP:0003974)2.66033021
35Carpal bone hypoplasia (HP:0001498)2.65815702
36Rhabdomyosarcoma (HP:0002859)2.64885898
37Bone marrow hypocellularity (HP:0005528)2.64641510
38Premature graying of hair (HP:0002216)2.64546741
39Multiple enchondromatosis (HP:0005701)2.60966506
40Absent thumb (HP:0009777)2.57805609
41Supernumerary spleens (HP:0009799)2.56709959
42Volvulus (HP:0002580)2.56657316
43Entropion (HP:0000621)2.53776772
44Rough bone trabeculation (HP:0100670)2.51286474
45Sloping forehead (HP:0000340)2.47472313
46Abnormal number of incisors (HP:0011064)2.46942016
47Absent forearm bone (HP:0003953)2.46283309
48Aplasia involving forearm bones (HP:0009822)2.46283309
49Missing ribs (HP:0000921)2.45200633
50Premature ovarian failure (HP:0008209)2.42163334
51Progressive external ophthalmoplegia (HP:0000590)2.38466553
52Increased serum lactate (HP:0002151)2.38367846
53Abnormality of the duodenum (HP:0002246)2.38310469
54Abnormal lung lobation (HP:0002101)2.36852302
55Triphalangeal thumb (HP:0001199)2.36544849
56Neoplasm of the pancreas (HP:0002894)2.35467569
57Sparse eyelashes (HP:0000653)2.32833478
58Ragged-red muscle fibers (HP:0003200)2.32549120
59Poikiloderma (HP:0001029)2.32445344
60Duplicated collecting system (HP:0000081)2.31909907
61Secondary amenorrhea (HP:0000869)2.31094084
62Nephroblastoma (Wilms tumor) (HP:0002667)2.29527726
63Impulsivity (HP:0100710)2.28533766
64Abnormality of the carotid arteries (HP:0005344)2.27752295
65Postnatal microcephaly (HP:0005484)2.23316858
66Tracheoesophageal fistula (HP:0002575)2.22136762
67Clubbing of toes (HP:0100760)2.20733486
68Optic nerve coloboma (HP:0000588)2.18299430
69Abnormality of methionine metabolism (HP:0010901)2.18173753
70Abnormal mitochondria in muscle tissue (HP:0008316)2.17607111
71Amaurosis fugax (HP:0100576)2.17254207
72Embryonal renal neoplasm (HP:0011794)2.14661043
73Lymphoma (HP:0002665)2.13923273
74Cleft eyelid (HP:0000625)2.12346015
75Neoplasm of the oral cavity (HP:0100649)2.10933145
76Abnormality of the renal collecting system (HP:0004742)2.09951813
77Horseshoe kidney (HP:0000085)2.09193952
78Prominent nose (HP:0000448)2.07783121
79Basal cell carcinoma (HP:0002671)2.07076236
80Abnormal protein glycosylation (HP:0012346)2.06878483
81Abnormal glycosylation (HP:0012345)2.06878483
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06878483
83Abnormal protein N-linked glycosylation (HP:0012347)2.06878483
84Atresia of the external auditory canal (HP:0000413)2.06745130
85Pallor (HP:0000980)2.06563548
86Macrocytic anemia (HP:0001972)2.06213648
87Abnormality of the umbilical cord (HP:0010881)2.05769962
88Stenosis of the external auditory canal (HP:0000402)2.04004218
89Pancytopenia (HP:0001876)2.02961121
90Astrocytoma (HP:0009592)2.02344211
91Abnormality of the astrocytes (HP:0100707)2.02344211
92Increased nuchal translucency (HP:0010880)2.02213885
93Acute encephalopathy (HP:0006846)2.02081636
94Biliary tract neoplasm (HP:0100574)2.01975888
95Proximal placement of thumb (HP:0009623)2.01189039
96Cellular immunodeficiency (HP:0005374)2.00702138
97Deviation of the thumb (HP:0009603)1.99681281
98Acute necrotizing encephalopathy (HP:0006965)1.99516623
99Glioma (HP:0009733)1.99385306
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.98885905
101Abnormal trabecular bone morphology (HP:0100671)1.96869852
102Ureteral duplication (HP:0000073)1.96485345
103Increased CSF lactate (HP:0002490)1.96355944
104Increased hepatocellular lipid droplets (HP:0006565)1.94401592
105Facial cleft (HP:0002006)1.94098476
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91658527
107Microretrognathia (HP:0000308)1.89659694
108Choanal atresia (HP:0000453)1.89450344
109Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88970521
110Cafe-au-lait spot (HP:0000957)1.88541001
111Trismus (HP:0000211)1.88354281
112Short thumb (HP:0009778)1.88104211
113Abnormality of DNA repair (HP:0003254)1.87543231
114Cutaneous melanoma (HP:0012056)1.87525821
115Neoplasm of striated muscle (HP:0009728)1.87114474
116Cortical dysplasia (HP:0002539)1.87027346
117Neoplasm of the colon (HP:0100273)1.86746648
118Hypoplasia of the radius (HP:0002984)1.85165286
119Abnormality of abdominal situs (HP:0011620)1.83302294
120Abdominal situs inversus (HP:0003363)1.83302294
121Deep philtrum (HP:0002002)1.82772692
122Abnormalities of placenta or umbilical cord (HP:0001194)1.82437765
123Squamous cell carcinoma (HP:0002860)1.81643426
124Fatigue (HP:0012378)1.81593985
125Hypergonadotropic hypogonadism (HP:0000815)1.81279453
126Reduced antithrombin III activity (HP:0001976)1.81248942
127Cerebral hypomyelination (HP:0006808)1.80697614
128Upper limb muscle weakness (HP:0003484)1.80307332
129Asplenia (HP:0001746)1.78255290
130Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77386007
131Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77386007
132Supernumerary bones of the axial skeleton (HP:0009144)1.75162326
133Spastic diplegia (HP:0001264)1.74495302
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74318142
135Freckling (HP:0001480)1.73877150
136Lactic acidosis (HP:0003128)1.73489255
137Shoulder girdle muscle weakness (HP:0003547)1.72482083
138Rectal fistula (HP:0100590)1.72209616
139Rectovaginal fistula (HP:0000143)1.72209616
140High anterior hairline (HP:0009890)1.71177794
141Type I transferrin isoform profile (HP:0003642)1.70437676
142Exercise intolerance (HP:0003546)1.70037696
143Insomnia (HP:0100785)1.69867892
144Cerebral edema (HP:0002181)1.69669289
145Hepatocellular necrosis (HP:0001404)1.69033643
146Hypoplastic pelvis (HP:0008839)1.67591062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.59849692
2WEE14.01863544
3BUB13.49394684
4SRPK13.18928756
5EIF2AK12.98825547
6VRK22.76828195
7TSSK62.49098040
8NEK22.40504486
9CDK122.36430974
10TTK2.22180360
11TLK12.19503069
12BRSK22.14620974
13PLK42.14605508
14EIF2AK32.10885655
15VRK12.10282705
16PLK12.03304081
17ATR2.03183939
18ACVR1B2.02673853
19PASK1.98933552
20MKNK11.98233693
21CDK71.92179030
22PLK31.87287460
23TRIM281.86664528
24MKNK21.79806805
25CCNB11.75049362
26AURKB1.68454563
27MST41.58279122
28NEK11.57705717
29BRD41.55385890
30STK161.54052642
31CHEK21.53866686
32DYRK31.51041770
33ZAK1.47464685
34PIM21.45045506
35RPS6KA41.44063747
36NME21.42371715
37CHEK11.40902596
38CDK41.38284145
39MST1R1.37619533
40STK41.33246129
41RPS6KB21.30148400
42TAF11.22629810
43SMG11.21782469
44EIF2AK21.21517146
45ATM1.18052321
46PIM11.16699489
47AKT31.12793298
48NUAK11.11847172
49CDK81.10412779
50AURKA1.08004450
51BRAF1.07557971
52EPHA21.07130535
53MAP3K81.05817369
54BRSK11.01213084
55ERBB41.00473551
56TGFBR10.95093863
57CDK20.94684782
58STK38L0.92489905
59PDK20.92268456
60NME10.90620666
61TESK20.89840802
62FLT30.89107209
63STK100.88697640
64PNCK0.86732958
65TXK0.85419264
66CDK10.75202651
67MAP4K10.73941613
68CSNK2A20.69216842
69MAP3K140.67619266
70CDK60.67023859
71CSNK2A10.66874476
72MELK0.64093995
73YES10.63601563
74RPS6KA50.60024998
75ALK0.59863136
76PAK40.59452682
77TAOK20.59315977
78MAP3K120.57420422
79CLK10.57377507
80EEF2K0.56342506
81STK30.55981731
82MET0.53548822
83SCYL20.52964764
84ERBB30.51466248
85PBK0.50955068
86JAK30.49497634
87BCR0.44657566
88SIK30.43773906
89KSR10.43172753
90KDR0.42335155
91PRKDC0.42319993
92IRAK40.41582510
93BCKDK0.41403758
94AKT20.40614110
95PAK10.40306898
96BTK0.40030064
97MAP3K100.39590547
98LIMK10.39122614
99DAPK10.37973024
100PRKCI0.37430324
101CHUK0.36358840
102RAF10.36262036
103MAPK140.35729348
104LATS20.35285557
105IRAK30.34718071
106PIK3CG0.34322167
107RPS6KB10.33687552
108CDK90.33628258
109LATS10.33366577
110CSNK1E0.32784809
111MARK30.31044887
112MTOR0.30818760
113TEC0.29968720
114AKT10.29307273
115MAP2K30.27971422
116NEK90.25982225
117MAPK110.25724816
118CSNK1D0.25666926
119MAP3K50.25543389
120CSNK1G30.24235619
121MAP2K20.24130800
122STK390.23002527
123CSNK1G10.22205721
124NLK0.21753585
125MAPK10.21511228
126CDK180.20346096
127GSK3B0.20204266
128STK240.20046157

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95254653
2Mismatch repair_Homo sapiens_hsa034304.46382725
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69725812
4* Spliceosome_Homo sapiens_hsa030403.32879957
5Base excision repair_Homo sapiens_hsa034103.28169938
6Homologous recombination_Homo sapiens_hsa034403.22265144
7RNA polymerase_Homo sapiens_hsa030203.20462476
8RNA transport_Homo sapiens_hsa030133.05005656
9Ribosome_Homo sapiens_hsa030102.90091189
10Nucleotide excision repair_Homo sapiens_hsa034202.83590664
11One carbon pool by folate_Homo sapiens_hsa006702.79975357
12Fanconi anemia pathway_Homo sapiens_hsa034602.79855668
13Cell cycle_Homo sapiens_hsa041102.78009195
14Non-homologous end-joining_Homo sapiens_hsa034502.52942304
15Proteasome_Homo sapiens_hsa030502.51022526
16Pyrimidine metabolism_Homo sapiens_hsa002402.42693513
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40297283
18RNA degradation_Homo sapiens_hsa030182.16782445
19Basal transcription factors_Homo sapiens_hsa030221.96978380
20mRNA surveillance pathway_Homo sapiens_hsa030151.95923589
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91801171
22p53 signaling pathway_Homo sapiens_hsa041151.54134953
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40435888
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37922643
25Purine metabolism_Homo sapiens_hsa002301.36155752
26Systemic lupus erythematosus_Homo sapiens_hsa053221.34349416
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26773406
28Carbon metabolism_Homo sapiens_hsa012001.24736097
29Herpes simplex infection_Homo sapiens_hsa051681.15388613
30Epstein-Barr virus infection_Homo sapiens_hsa051691.12898172
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11698365
32Pyruvate metabolism_Homo sapiens_hsa006201.09902339
33Fatty acid elongation_Homo sapiens_hsa000621.07480444
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03609077
35Antigen processing and presentation_Homo sapiens_hsa046121.03101682
36Protein export_Homo sapiens_hsa030601.00602396
37Viral carcinogenesis_Homo sapiens_hsa052030.99553166
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96771186
39Parkinsons disease_Homo sapiens_hsa050120.95101829
40Selenocompound metabolism_Homo sapiens_hsa004500.93772242
41Steroid biosynthesis_Homo sapiens_hsa001000.90215292
42HTLV-I infection_Homo sapiens_hsa051660.87427708
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86150098
44Oxidative phosphorylation_Homo sapiens_hsa001900.84771404
45Primary immunodeficiency_Homo sapiens_hsa053400.82608492
46Oocyte meiosis_Homo sapiens_hsa041140.77385015
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74054393
48Thyroid cancer_Homo sapiens_hsa052160.72969286
49Propanoate metabolism_Homo sapiens_hsa006400.70632699
50MicroRNAs in cancer_Homo sapiens_hsa052060.70149315
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.69913395
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66807566
53Measles_Homo sapiens_hsa051620.65460282
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61259396
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60976012
56Folate biosynthesis_Homo sapiens_hsa007900.58800842
57Legionellosis_Homo sapiens_hsa051340.58736337
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58285442
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58231092
60Alcoholism_Homo sapiens_hsa050340.53452245
61Small cell lung cancer_Homo sapiens_hsa052220.53312711
62Basal cell carcinoma_Homo sapiens_hsa052170.52386564
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52006175
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.51996257
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.51916937
66Allograft rejection_Homo sapiens_hsa053300.50998984
67Apoptosis_Homo sapiens_hsa042100.50473391
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.50357203
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.48031816
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46906412
71Hepatitis B_Homo sapiens_hsa051610.46844518
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46582177
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.46336914
74Colorectal cancer_Homo sapiens_hsa052100.45800143
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43527531
76Metabolic pathways_Homo sapiens_hsa011000.43191824
77Influenza A_Homo sapiens_hsa051640.43174024
78Pentose phosphate pathway_Homo sapiens_hsa000300.42679415
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41814191
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40547983
81Fructose and mannose metabolism_Homo sapiens_hsa000510.40320655
82Biosynthesis of amino acids_Homo sapiens_hsa012300.39892439
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39410987
84Hematopoietic cell lineage_Homo sapiens_hsa046400.38313514
85TGF-beta signaling pathway_Homo sapiens_hsa043500.38286481
86Galactose metabolism_Homo sapiens_hsa000520.37747058
87Acute myeloid leukemia_Homo sapiens_hsa052210.37562064
88N-Glycan biosynthesis_Homo sapiens_hsa005100.37385176
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36852152
90Hippo signaling pathway_Homo sapiens_hsa043900.36756188
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36322759
92Alzheimers disease_Homo sapiens_hsa050100.36264689
93Sulfur metabolism_Homo sapiens_hsa009200.34600215
94Lysine degradation_Homo sapiens_hsa003100.33219467
95Prostate cancer_Homo sapiens_hsa052150.32787441
96Chronic myeloid leukemia_Homo sapiens_hsa052200.30318263
97Vitamin B6 metabolism_Homo sapiens_hsa007500.30216416
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28732171
99Pathways in cancer_Homo sapiens_hsa052000.28664157
100Fatty acid metabolism_Homo sapiens_hsa012120.28477120
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28102335
102Autoimmune thyroid disease_Homo sapiens_hsa053200.27147626
103Type I diabetes mellitus_Homo sapiens_hsa049400.26673186
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26632341
105Viral myocarditis_Homo sapiens_hsa054160.26096190
106Huntingtons disease_Homo sapiens_hsa050160.25413775
107Notch signaling pathway_Homo sapiens_hsa043300.24243557
108Graft-versus-host disease_Homo sapiens_hsa053320.23763069
109Glutathione metabolism_Homo sapiens_hsa004800.21886615
110Hedgehog signaling pathway_Homo sapiens_hsa043400.20812151
111Arginine and proline metabolism_Homo sapiens_hsa003300.20613585
112Bladder cancer_Homo sapiens_hsa052190.19583321
113Vibrio cholerae infection_Homo sapiens_hsa051100.19405374
114Shigellosis_Homo sapiens_hsa051310.19077193
115Asthma_Homo sapiens_hsa053100.18859145
116T cell receptor signaling pathway_Homo sapiens_hsa046600.18302209
117Adherens junction_Homo sapiens_hsa045200.17518719
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.15595029
119Pancreatic cancer_Homo sapiens_hsa052120.14945376
120Wnt signaling pathway_Homo sapiens_hsa043100.14838605
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14366610
122Peroxisome_Homo sapiens_hsa041460.13938711
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12780628
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11770808
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11511678
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11402631
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.11379010
128Endometrial cancer_Homo sapiens_hsa052130.10993819
129Sulfur relay system_Homo sapiens_hsa041220.10780677
130FoxO signaling pathway_Homo sapiens_hsa040680.10755701

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