PRPF39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.75618617
2intraciliary transport (GO:0042073)4.22673305
3poly(A)+ mRNA export from nucleus (GO:0016973)4.03319429
4regulation of DNA endoreduplication (GO:0032875)3.98183511
5regulation of nuclear cell cycle DNA replication (GO:0033262)3.94934358
6intra-S DNA damage checkpoint (GO:0031573)3.72687204
7definitive hemopoiesis (GO:0060216)3.71557578
8RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.69349023
9keratinocyte development (GO:0003334)3.68127613
10kinetochore organization (GO:0051383)3.65518252
11protein prenylation (GO:0018342)3.55252576
12prenylation (GO:0097354)3.55252576
13DNA topological change (GO:0006265)3.49738894
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.49473552
15cell differentiation involved in metanephros development (GO:0072202)3.48461160
16replication fork processing (GO:0031297)3.40984358
17regulation of mitotic spindle checkpoint (GO:1903504)3.35511946
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35511946
19postreplication repair (GO:0006301)3.34528957
20kinetochore assembly (GO:0051382)3.31382669
21DNA deamination (GO:0045006)3.31115433
22response to pheromone (GO:0019236)3.28805165
23interferon-gamma production (GO:0032609)3.28550733
24kidney morphogenesis (GO:0060993)3.28024799
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.26944670
26mesenchymal cell differentiation involved in kidney development (GO:0072161)3.26944670
27somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.25825057
28somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.25825057
29isotype switching (GO:0045190)3.25825057
30double-strand break repair via homologous recombination (GO:0000724)3.20611969
31recombinational repair (GO:0000725)3.19455076
32cornea development in camera-type eye (GO:0061303)3.16974455
33synapsis (GO:0007129)3.16604492
34regulation of glucokinase activity (GO:0033131)3.16036291
35regulation of hexokinase activity (GO:1903299)3.16036291
36regulation of meiosis I (GO:0060631)3.14590815
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10603312
38regulation of memory T cell differentiation (GO:0043380)3.08844903
39viral mRNA export from host cell nucleus (GO:0046784)3.07397770
40negative regulation of keratinocyte proliferation (GO:0010839)3.06787213
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04729574
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.04729574
43regulation of translation, ncRNA-mediated (GO:0045974)3.04729574
44limb bud formation (GO:0060174)3.03919991
45respiratory chain complex IV assembly (GO:0008535)3.02435752
46purine nucleobase biosynthetic process (GO:0009113)3.02104034
47cytochrome complex assembly (GO:0017004)3.00243685
48DNA catabolic process, exonucleolytic (GO:0000738)2.99349851
49protein K6-linked ubiquitination (GO:0085020)2.98782039
50RNA-dependent DNA replication (GO:0006278)2.97931725
51DNA replication checkpoint (GO:0000076)2.97146167
52DNA ligation (GO:0006266)2.97013965
53water-soluble vitamin biosynthetic process (GO:0042364)2.89475658
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83834028
55pyrimidine dimer repair (GO:0006290)2.82988031
56L-fucose metabolic process (GO:0042354)2.82332513
57L-fucose catabolic process (GO:0042355)2.82332513
58fucose catabolic process (GO:0019317)2.82332513
59DNA replication-dependent nucleosome assembly (GO:0006335)2.81871015
60DNA replication-dependent nucleosome organization (GO:0034723)2.81871015
61rRNA catabolic process (GO:0016075)2.80745054
62polyol catabolic process (GO:0046174)2.80526231
63meiotic chromosome segregation (GO:0045132)2.79831993
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79271223
65centriole replication (GO:0007099)2.78887293
66CENP-A containing nucleosome assembly (GO:0034080)2.78609119
67transcription elongation from RNA polymerase I promoter (GO:0006362)2.78127244
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.76615609
69somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76615609
70protein K11-linked deubiquitination (GO:0035871)2.76528079
71protein localization to microtubule cytoskeleton (GO:0072698)2.76465821
72S-adenosylmethionine metabolic process (GO:0046500)2.76048155
73lactate metabolic process (GO:0006089)2.76012196
74negative regulation of glycogen biosynthetic process (GO:0045719)2.75174046
75neural tube formation (GO:0001841)2.72273419
76mitotic sister chromatid cohesion (GO:0007064)2.71041236
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70835753
78histamine secretion (GO:0001821)2.67028102
79positive regulation of DNA-dependent DNA replication (GO:2000105)2.66974112
80metaphase plate congression (GO:0051310)2.66959762
81mRNA splice site selection (GO:0006376)2.66928990
82establishment of protein localization to Golgi (GO:0072600)2.66431565
83termination of RNA polymerase I transcription (GO:0006363)2.66350875
84magnesium ion transport (GO:0015693)2.64297182
85histone exchange (GO:0043486)2.63475463
86centriole assembly (GO:0098534)2.63241046
87protein targeting to Golgi (GO:0000042)2.62759466
88purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.62664851
89DNA demethylation (GO:0080111)2.62251967
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61744305
91ncRNA catabolic process (GO:0034661)2.60970852
92regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60414764
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60397976
94positive regulation of glycoprotein biosynthetic process (GO:0010560)2.59859874
95IMP biosynthetic process (GO:0006188)2.59231713
96metanephric mesenchyme development (GO:0072075)2.59034664
97somatic diversification of immunoglobulins (GO:0016445)2.58891836
98chromatin remodeling at centromere (GO:0031055)2.58261922
99mitochondrial RNA metabolic process (GO:0000959)2.57602142
100platelet dense granule organization (GO:0060155)2.56214754
101tRNA methylation (GO:0030488)2.56209227
102ribosome assembly (GO:0042255)2.54874245
103protein localization to cilium (GO:0061512)2.53117932
104response to X-ray (GO:0010165)2.52694902
105nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.52418041
106prostate gland growth (GO:0060736)2.50403457
107protein complex biogenesis (GO:0070271)2.49703579
108histone H2A ubiquitination (GO:0033522)2.49605015
109branched-chain amino acid catabolic process (GO:0009083)2.49203621
110transcription initiation from RNA polymerase I promoter (GO:0006361)2.48256391
111regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48064173
112somatic recombination of immunoglobulin gene segments (GO:0016447)2.47790882
113kidney mesenchyme development (GO:0072074)2.47234729
114protein localization to cytoskeleton (GO:0044380)2.46839799
115histone H2A acetylation (GO:0043968)2.46274709
116positive regulation of protein autophosphorylation (GO:0031954)2.45971208
117regulation of histone H3-K27 methylation (GO:0061085)2.45390336
118regulation of centriole replication (GO:0046599)2.45264414
119mitotic metaphase plate congression (GO:0007080)2.44854977
120regulation of telomere maintenance (GO:0032204)2.44604165
121regulation of fibroblast apoptotic process (GO:2000269)2.43617011
122embryonic epithelial tube formation (GO:0001838)2.43483001
123DNA-dependent DNA replication (GO:0006261)2.43361497
124double-strand break repair (GO:0006302)2.43108828
125histone mRNA metabolic process (GO:0008334)2.43033816
126interkinetic nuclear migration (GO:0022027)2.42898568
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42481658
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42481658
129positive regulation of glycolytic process (GO:0045821)2.41839800
130transcription from mitochondrial promoter (GO:0006390)2.41473135
1317-methylguanosine mRNA capping (GO:0006370)2.40594947
132sister chromatid cohesion (GO:0007062)2.40345862
133inositol phosphate catabolic process (GO:0071545)2.40321848
134cilium morphogenesis (GO:0060271)2.39747514
135RNA capping (GO:0036260)2.39349825
1367-methylguanosine RNA capping (GO:0009452)2.39349825
137photoreceptor cell maintenance (GO:0045494)2.38968963
138axoneme assembly (GO:0035082)2.38728327
139positive regulation of mitochondrial fission (GO:0090141)2.38640262
140positive regulation of cell fate commitment (GO:0010455)2.38467402
141regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38006357
142regulation of respiratory burst (GO:0060263)2.37980818
143methionine biosynthetic process (GO:0009086)2.37684377
144nucleobase biosynthetic process (GO:0046112)2.37325882
145peptidyl-histidine modification (GO:0018202)2.36979565
146regulation of T cell chemotaxis (GO:0010819)2.36967399
147positive regulation of T cell chemotaxis (GO:0010820)2.36967399
148cullin deneddylation (GO:0010388)2.36559501
149positive regulation of mRNA metabolic process (GO:1903313)2.36376426
150nuclear pore complex assembly (GO:0051292)2.36216305
151negative regulation of phagocytosis (GO:0050765)2.36197350
152mRNA export from nucleus (GO:0006406)2.36184311
153DNA replication-independent nucleosome assembly (GO:0006336)2.33826200
154DNA replication-independent nucleosome organization (GO:0034724)2.33826200
155transcription from RNA polymerase I promoter (GO:0006360)2.33254204
156dentate gyrus development (GO:0021542)2.32707979
157necrotic cell death (GO:0070265)2.30830476
158DNA-templated transcription, termination (GO:0006353)2.29770847
159histamine transport (GO:0051608)2.28584803
160protein K11-linked ubiquitination (GO:0070979)2.28562204
161regulation of interleukin-8 secretion (GO:2000482)2.28196630
162pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.27990985
163superoxide anion generation (GO:0042554)2.26910889
164telomere maintenance via recombination (GO:0000722)2.26865925
165negative regulation of mast cell activation (GO:0033004)2.26170539
166signal peptide processing (GO:0006465)2.25972486
167telomere maintenance via telomerase (GO:0007004)2.24935118
168telomere maintenance (GO:0000723)2.23991863
169mitochondrial respiratory chain complex I assembly (GO:0032981)2.23894413
170NADH dehydrogenase complex assembly (GO:0010257)2.23894413
171mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.23894413
172positive regulation of T cell migration (GO:2000406)2.23784557
173adenosine metabolic process (GO:0046085)2.22949082
174viral protein processing (GO:0019082)2.22682611
175smooth muscle tissue development (GO:0048745)2.21059202
176negative regulation of myoblast differentiation (GO:0045662)2.20586712
177negative regulation of dendrite morphogenesis (GO:0050774)2.20160090
178mitochondrial respiratory chain complex assembly (GO:0033108)2.19406178
179V(D)J recombination (GO:0033151)2.18623351
180GMP metabolic process (GO:0046037)2.18549985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25099860
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.05895595
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.85613844
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14360053
5ZNF274_21170338_ChIP-Seq_K562_Hela3.05053098
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85853857
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.79645185
8GBX2_23144817_ChIP-Seq_PC3_Human2.75296108
9VDR_22108803_ChIP-Seq_LS180_Human2.55076344
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52826306
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.49252343
12FUS_26573619_Chip-Seq_HEK293_Human2.44732702
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31678457
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.26601756
15EWS_26573619_Chip-Seq_HEK293_Human2.26566573
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18991546
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.16670570
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11316531
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04642863
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02241831
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.01906154
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88711094
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86258494
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84292237
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83648389
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81408335
27IGF1R_20145208_ChIP-Seq_DFB_Human1.73930513
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73711787
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73459506
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73164371
31* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71098642
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70832680
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70575622
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68809549
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.65402964
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63257184
37P300_19829295_ChIP-Seq_ESCs_Human1.59024766
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58458285
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51736181
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51027400
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50680405
42MYC_18940864_ChIP-ChIP_HL60_Human1.49115103
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46916799
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45293760
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44453780
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.43933509
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43702134
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.42969576
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42841150
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41808107
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40649558
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.39893010
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39533078
54TAF15_26573619_Chip-Seq_HEK293_Human1.39394753
55BCAT_22108803_ChIP-Seq_LS180_Human1.39385323
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38401248
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.37566231
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.37373681
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35481749
60P53_22387025_ChIP-Seq_ESCs_Mouse1.34776470
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34558258
62CBP_20019798_ChIP-Seq_JUKART_Human1.32479850
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32479850
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.32071043
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.31308109
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31079082
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.30824494
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29986203
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29167956
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.29146722
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.27656907
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27129657
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.26536189
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25950539
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.25874912
76P300_18555785_Chip-Seq_ESCs_Mouse1.25360500
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23409000
78TCF4_22108803_ChIP-Seq_LS180_Human1.23068794
79VDR_23849224_ChIP-Seq_CD4+_Human1.22290598
80STAT3_23295773_ChIP-Seq_U87_Human1.21726046
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.21408949
82AR_25329375_ChIP-Seq_VCAP_Human1.20443430
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19698972
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19668467
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19575974
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19355801
87RNF2_27304074_Chip-Seq_NSC_Mouse1.18996645
88NANOG_19829295_ChIP-Seq_ESCs_Human1.18638647
89SOX2_19829295_ChIP-Seq_ESCs_Human1.18638647
90RUNX_20019798_ChIP-Seq_JUKART_Human1.17944764
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16888232
92TP53_22573176_ChIP-Seq_HFKS_Human1.16272408
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16024998
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14044025
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.12157484
96CDX2_22108803_ChIP-Seq_LS180_Human1.12124544
97ER_23166858_ChIP-Seq_MCF-7_Human1.12103211
98IRF1_19129219_ChIP-ChIP_H3396_Human1.11793862
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11386058
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11126905
101* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10764744
102GABP_17652178_ChIP-ChIP_JURKAT_Human1.10563641
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.10480296
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09608890
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09433730
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09148733
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.09129141
108RUNX2_22187159_ChIP-Seq_PCA_Human1.09055508
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09040124
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09038806
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09024467
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08753429
113SCL_19346495_ChIP-Seq_HPC-7_Human1.07213490
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06374621
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06233409
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.05789655
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.05628243
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05628243
119SMAD4_21799915_ChIP-Seq_A2780_Human1.04532308
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03988909
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03421408
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03114100
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02667863
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01913391
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01502803
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00210990
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.99059686
128PU1_27457419_Chip-Seq_LIVER_Mouse0.97860737
129FOXP3_21729870_ChIP-Seq_TREG_Human0.96513587
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95589844
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94942747
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93872194
133TCF4_23295773_ChIP-Seq_U87_Human0.92735647
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92146292
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.91804067
136GATA1_22025678_ChIP-Seq_K562_Human0.91715869
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91543461
138* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90615264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.10741934
2MP0001986_abnormal_taste_sensitivity3.50574928
3MP0002102_abnormal_ear_morphology3.42146347
4MP0006292_abnormal_olfactory_placode3.40416336
5MP0002009_preneoplasia3.14084737
6MP0005171_absent_coat_pigmentation2.81230612
7MP0001188_hyperpigmentation2.73208469
8MP0009697_abnormal_copulation2.35212955
9MP0000015_abnormal_ear_pigmentation2.33483705
10MP0008007_abnormal_cellular_replicative2.22608703
11MP0008058_abnormal_DNA_repair2.20029746
12MP0005075_abnormal_melanosome_morpholog2.19656209
13MP0002938_white_spotting2.16839554
14MP0006072_abnormal_retinal_apoptosis2.15505707
15MP0002277_abnormal_respiratory_mucosa2.12525801
16MP0000566_synostosis2.12403126
17MP0003121_genomic_imprinting2.11834098
18MP0000383_abnormal_hair_follicle2.07201445
19MP0002095_abnormal_skin_pigmentation2.03822500
20MP0005367_renal/urinary_system_phenotyp1.99684649
21MP0000516_abnormal_urinary_system1.99684649
22MP0005646_abnormal_pituitary_gland1.90991929
23MP0003943_abnormal_hepatobiliary_system1.89345890
24MP0005551_abnormal_eye_electrophysiolog1.86704333
25MP0010094_abnormal_chromosome_stability1.85993705
26MP0002396_abnormal_hematopoietic_system1.85233625
27MP0002837_dystrophic_cardiac_calcinosis1.80613032
28MP0010678_abnormal_skin_adnexa1.76799724
29MP0002163_abnormal_gland_morphology1.75221890
30MP0004808_abnormal_hematopoietic_stem1.71081367
31MP0000647_abnormal_sebaceous_gland1.70135904
32MP0003136_yellow_coat_color1.70056392
33MP0004782_abnormal_surfactant_physiolog1.69444972
34MP0005253_abnormal_eye_physiology1.69435379
35MP0000427_abnormal_hair_cycle1.69145970
36MP0000569_abnormal_digit_pigmentation1.63765784
37MP0002234_abnormal_pharynx_morphology1.57474827
38MP0005174_abnormal_tail_pigmentation1.55545205
39MP0003693_abnormal_embryo_hatching1.54723386
40MP0005503_abnormal_tendon_morphology1.54444542
41MP0002751_abnormal_autonomic_nervous1.54154717
42MP0001835_abnormal_antigen_presentation1.50328719
43MP0008877_abnormal_DNA_methylation1.48407660
44MP0003880_abnormal_central_pattern1.46353079
45MP0000372_irregular_coat_pigmentation1.42996001
46MP0005408_hypopigmentation1.41128323
47MP0004043_abnormal_pH_regulation1.39974059
48MP0004215_abnormal_myocardial_fiber1.38804256
49MP0003763_abnormal_thymus_physiology1.37947136
50MP0001919_abnormal_reproductive_system1.36476997
51MP0008057_abnormal_DNA_replication1.33791910
52MP0002148_abnormal_hypersensitivity_rea1.29584715
53MP0001186_pigmentation_phenotype1.28136679
54MP0001177_atelectasis1.28084925
55MP0010386_abnormal_urinary_bladder1.26376192
56MP0002132_abnormal_respiratory_system1.26168611
57MP0008872_abnormal_physiological_respon1.26010294
58MP0003786_premature_aging1.24194420
59MP0003567_abnormal_fetal_cardiomyocyte1.24186714
60MP0010030_abnormal_orbit_morphology1.23850113
61MP0002638_abnormal_pupillary_reflex1.23798290
62MP0005671_abnormal_response_to1.21032069
63MP0009780_abnormal_chondrocyte_physiolo1.20913749
64MP0003119_abnormal_digestive_system1.17486542
65MP0001984_abnormal_olfaction1.16972600
66MP0009046_muscle_twitch1.14955738
67MP0002006_tumorigenesis1.12659031
68MP0000613_abnormal_salivary_gland1.11673924
69MP0001119_abnormal_female_reproductive1.11178688
70MP0000681_abnormal_thyroid_gland1.10663513
71MP0003077_abnormal_cell_cycle1.08890287
72MP0008789_abnormal_olfactory_epithelium1.07609763
73MP0002075_abnormal_coat/hair_pigmentati1.07282100
74MP0005389_reproductive_system_phenotype1.07183894
75MP0003283_abnormal_digestive_organ1.07051798
76MP0005645_abnormal_hypothalamus_physiol1.06651639
77MP0002166_altered_tumor_susceptibility1.06514162
78MP0003122_maternal_imprinting1.06425909
79MP0001764_abnormal_homeostasis1.04087754
80MP0003937_abnormal_limbs/digits/tail_de1.03929292
81MP0001879_abnormal_lymphatic_vessel1.03462536
82MP0003315_abnormal_perineum_morphology1.03388792
83MP0003941_abnormal_skin_development1.01634530
84MP0001929_abnormal_gametogenesis0.99436637
85MP0004147_increased_porphyrin_level0.98288498
86MP0005409_darkened_coat_color0.96044986
87MP0002090_abnormal_vision0.95775647
88MP0002876_abnormal_thyroid_physiology0.94722699
89MP0003718_maternal_effect0.93588432
90MP0003195_calcinosis0.92689902
91MP0000490_abnormal_crypts_of0.92445075
92MP0006036_abnormal_mitochondrial_physio0.92141677
93MP0000631_abnormal_neuroendocrine_gland0.91960861
94MP0000653_abnormal_sex_gland0.91604265
95MP0005379_endocrine/exocrine_gland_phen0.90866610
96MP0002254_reproductive_system_inflammat0.90275902
97MP0005220_abnormal_exocrine_pancreas0.90256554
98MP0001486_abnormal_startle_reflex0.89890324
99MP0001968_abnormal_touch/_nociception0.88412635
100MP0000767_abnormal_smooth_muscle0.87687037
101MP0003123_paternal_imprinting0.87094444
102MP0004133_heterotaxia0.86896771
103MP0003890_abnormal_embryonic-extraembry0.86241543
104MP0003111_abnormal_nucleus_morphology0.85721438
105MP0002160_abnormal_reproductive_system0.85438343
106MP0002736_abnormal_nociception_after0.85323948
107MP0002398_abnormal_bone_marrow0.83838282
108MP0001324_abnormal_eye_pigmentation0.82776956
109MP0001145_abnormal_male_reproductive0.82481691
110MP0001800_abnormal_humoral_immune0.81279816
111MP0002420_abnormal_adaptive_immunity0.81116019
112MP0002233_abnormal_nose_morphology0.81018804
113MP0009703_decreased_birth_body0.80722807
114MP0000049_abnormal_middle_ear0.80507460
115MP0006276_abnormal_autonomic_nervous0.80081288
116MP0001819_abnormal_immune_cell0.79796035
117MP0003950_abnormal_plasma_membrane0.79470179
118MP0002452_abnormal_antigen_presenting0.78895939
119MP0002177_abnormal_outer_ear0.78750608
120MP0001529_abnormal_vocalization0.77358049
121MP0006054_spinal_hemorrhage0.77263785
122MP0005391_vision/eye_phenotype0.76997401
123MP0002210_abnormal_sex_determination0.76910026
124MP0005499_abnormal_olfactory_system0.76735014
125MP0005394_taste/olfaction_phenotype0.76735014
126MP0001293_anophthalmia0.76453797
127MP0008995_early_reproductive_senescence0.76361962
128MP0005084_abnormal_gallbladder_morpholo0.75633862
129MP0005248_abnormal_Harderian_gland0.75585301
130MP0004924_abnormal_behavior0.75055958
131MP0005386_behavior/neurological_phenoty0.75055958
132MP0003724_increased_susceptibility_to0.73531242
133MP0003698_abnormal_male_reproductive0.70364839
134MP0002109_abnormal_limb_morphology0.69821348
135MP0000371_diluted_coat_color0.69402534
136MP0010155_abnormal_intestine_physiology0.68942283
137MP0008775_abnormal_heart_ventricle0.68466771
138MP0001270_distended_abdomen0.68041750
139MP0003137_abnormal_impulse_conducting0.68033137
140MP0004197_abnormal_fetal_growth/weight/0.67750529
141MP0005508_abnormal_skeleton_morphology0.67612192
142MP0002723_abnormal_immune_serum0.67473411
143MP0005187_abnormal_penis_morphology0.67373315
144MP0004957_abnormal_blastocyst_morpholog0.67179040
145MP0004381_abnormal_hair_follicle0.67112150
146MP0009250_abnormal_appendicular_skeleto0.67037100
147MP0008932_abnormal_embryonic_tissue0.66433913
148MP0000703_abnormal_thymus_morphology0.66068314
149MP0001545_abnormal_hematopoietic_system0.65738716
150MP0005397_hematopoietic_system_phenotyp0.65738716
151MP0001502_abnormal_circadian_rhythm0.65178051
152MP0000716_abnormal_immune_system0.64805003
153MP0001790_abnormal_immune_system0.63446193
154MP0005387_immune_system_phenotype0.63446193
155MP0001286_abnormal_eye_development0.63413140

Predicted human phenotypes

RankGene SetZ-score
1Protruding tongue (HP:0010808)3.39756080
2Abnormality of incisor morphology (HP:0011063)3.36118284
3Pancreatic islet-cell hyperplasia (HP:0004510)3.24364461
4Volvulus (HP:0002580)3.21344491
5Patchy hypopigmentation of hair (HP:0011365)3.18195702
6Syringomyelia (HP:0003396)3.16860898
7Spinal cord lesions (HP:0100561)3.16860898
8Abnormality of the renal cortex (HP:0011035)3.16620005
9Absent frontal sinuses (HP:0002688)3.03422152
10True hermaphroditism (HP:0010459)3.01966655
11Abnormal hair whorl (HP:0010721)2.98085731
12Hypothermia (HP:0002045)2.97699765
13Type I transferrin isoform profile (HP:0003642)2.97502861
14Abnormality of the incisor (HP:0000676)2.79342330
15Congenital stationary night blindness (HP:0007642)2.75248848
16Chronic hepatic failure (HP:0100626)2.68549712
17Abnormality of the labia minora (HP:0012880)2.66040450
18Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.64408228
19Methylmalonic acidemia (HP:0002912)2.62565795
20Pancreatic fibrosis (HP:0100732)2.57881089
21Chromsome breakage (HP:0040012)2.57764566
22Aplastic anemia (HP:0001915)2.53354210
23Hypochromic microcytic anemia (HP:0004840)2.52753080
24Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.46234704
25Hyperinsulinemic hypoglycemia (HP:0000825)2.44164415
26White forelock (HP:0002211)2.43243493
27Thyroiditis (HP:0100646)2.43238024
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.41779862
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35567260
30Hypoglycemic coma (HP:0001325)2.34565526
31Abnormality of endocrine pancreas physiology (HP:0012093)2.32071674
32Abnormality of the pancreatic islet cells (HP:0006476)2.32071674
33Hypoglycemic seizures (HP:0002173)2.30289124
34Birth length less than 3rd percentile (HP:0003561)2.29884434
35Acute myeloid leukemia (HP:0004808)2.29210952
36Reduced antithrombin III activity (HP:0001976)2.27315008
37Abnormality of vitamin B metabolism (HP:0004340)2.25967547
38Abnormality of the nasal septum (HP:0000419)2.23093658
39Molar tooth sign on MRI (HP:0002419)2.22992752
40Abnormality of midbrain morphology (HP:0002418)2.22992752
41Nephroblastoma (Wilms tumor) (HP:0002667)2.22551800
42Type 2 muscle fiber atrophy (HP:0003554)2.21909056
43Abnormality of the frontal sinuses (HP:0002687)2.20609212
44Severe visual impairment (HP:0001141)2.19626320
45Hypomagnesemia (HP:0002917)2.19198076
46Renal cortical cysts (HP:0000803)2.18650154
47Fair hair (HP:0002286)2.16150742
48Submucous cleft hard palate (HP:0000176)2.12877389
49Abolished electroretinogram (ERG) (HP:0000550)2.10092873
50Progressive inability to walk (HP:0002505)2.08993376
51Ketoacidosis (HP:0001993)2.08976786
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08405025
53Embryonal renal neoplasm (HP:0011794)2.07879255
54Asymmetry of the thorax (HP:0001555)2.04426111
55Gait imbalance (HP:0002141)2.03657324
56Abnormality of methionine metabolism (HP:0010901)2.03654992
57Myelodysplasia (HP:0002863)2.02358268
58Deep philtrum (HP:0002002)2.01769807
59Breast carcinoma (HP:0003002)2.01096952
60Abnormality of the vitamin B12 metabolism (HP:0004341)1.98561368
61Alveolar cell carcinoma (HP:0006519)1.97242565
62Gonadotropin excess (HP:0000837)1.96197110
63Abnormality of the heme biosynthetic pathway (HP:0010472)1.96106712
64Sloping forehead (HP:0000340)1.95928347
65Generalized hypopigmentation of hair (HP:0011358)1.95709014
66Lip pit (HP:0100267)1.94897475
67Congenital malformation of the right heart (HP:0011723)1.94864559
68Double outlet right ventricle (HP:0001719)1.94864559
69Pancreatic cysts (HP:0001737)1.94330862
70Abnormal lung lobation (HP:0002101)1.92996078
71Glioma (HP:0009733)1.92216496
72Genital tract atresia (HP:0001827)1.91550575
73Postaxial foot polydactyly (HP:0001830)1.90739545
74Severe combined immunodeficiency (HP:0004430)1.89721321
75Encephalitis (HP:0002383)1.89155506
76Ependymoma (HP:0002888)1.87983271
77Homocystinuria (HP:0002156)1.87829965
78Abnormality of homocysteine metabolism (HP:0010919)1.87829965
79Hyperventilation (HP:0002883)1.86564872
80Vaginal atresia (HP:0000148)1.85975578
81Intestinal atresia (HP:0011100)1.85852275
82Preaxial hand polydactyly (HP:0001177)1.84823770
83Abnormal protein glycosylation (HP:0012346)1.84317129
84Abnormal glycosylation (HP:0012345)1.84317129
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84317129
86Abnormal protein N-linked glycosylation (HP:0012347)1.84317129
87Dandy-Walker malformation (HP:0001305)1.83392220
88Stomach cancer (HP:0012126)1.83014013
89Occipital encephalocele (HP:0002085)1.82976408
90Abnormality of the fovea (HP:0000493)1.82665297
91Disproportionate short-trunk short stature (HP:0003521)1.82089522
92Prostate neoplasm (HP:0100787)1.81937374
93Attenuation of retinal blood vessels (HP:0007843)1.81855525
94Abnormal biliary tract physiology (HP:0012439)1.81686269
95Bile duct proliferation (HP:0001408)1.81686269
96Methylmalonic aciduria (HP:0012120)1.79833642
97Febrile seizures (HP:0002373)1.79268306
98Pulmonary artery stenosis (HP:0004415)1.78839869
99Aqueductal stenosis (HP:0002410)1.78746845
100Abnormality of the duodenum (HP:0002246)1.78613245
101Neoplasm of the adrenal gland (HP:0100631)1.78409474
102Abnormality of the preputium (HP:0100587)1.78247534
103Amyotrophic lateral sclerosis (HP:0007354)1.78107700
104Abnormal rod and cone electroretinograms (HP:0008323)1.77970748
105Shawl scrotum (HP:0000049)1.77423577
106Abnormality of the fingertips (HP:0001211)1.77128686
107Ectopic kidney (HP:0000086)1.77096607
108Nephrogenic diabetes insipidus (HP:0009806)1.76579510
109Clubbing of toes (HP:0100760)1.75389653
110Albinism (HP:0001022)1.75164275
111Neoplasm of the adrenal cortex (HP:0100641)1.75118341
112Intestinal fistula (HP:0100819)1.75077515
113Meckel diverticulum (HP:0002245)1.73878485
114Small intestinal stenosis (HP:0012848)1.73579238
115Duodenal stenosis (HP:0100867)1.73579238
116Astigmatism (HP:0000483)1.73328332
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.72961085
118Microvesicular hepatic steatosis (HP:0001414)1.72382980
119Heterochromia iridis (HP:0001100)1.72230928
120Optic nerve coloboma (HP:0000588)1.72152272
121Hypochromic anemia (HP:0001931)1.72086654
122Astrocytoma (HP:0009592)1.71994691
123Abnormality of the astrocytes (HP:0100707)1.71994691
124Tongue fasciculations (HP:0001308)1.71972657
125Optic nerve hypoplasia (HP:0000609)1.71635716
126Nephronophthisis (HP:0000090)1.71469469
127Aplasia cutis congenita (HP:0001057)1.71050491
128Hyperglycinemia (HP:0002154)1.70945926
129Muscle fiber atrophy (HP:0100295)1.69963570
130Furrowed tongue (HP:0000221)1.69804390
131Rhabdomyosarcoma (HP:0002859)1.69618390
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.69474768
13311 pairs of ribs (HP:0000878)1.69360257
134Long foot (HP:0001833)1.69128079
135Increased number of teeth (HP:0011069)1.69095490
136Abnormality of chromosome stability (HP:0003220)1.67918789
137Abnormality of the metopic suture (HP:0005556)1.67134278
138Medial flaring of the eyebrow (HP:0010747)1.66719521
139Congenital, generalized hypertrichosis (HP:0004540)1.66425051
140Median cleft lip (HP:0000161)1.65944111
141Congenital primary aphakia (HP:0007707)1.64813667
142Growth hormone deficiency (HP:0000824)1.64292427
143Neoplasm of the tracheobronchial system (HP:0100552)1.64274179
144Abnormality of alanine metabolism (HP:0010916)1.64265271
145Hyperalaninemia (HP:0003348)1.64265271
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64265271
147Supernumerary spleens (HP:0009799)1.64114021
148Abnormality of the right ventricle (HP:0001707)1.64026772
149Hyperglycemia (HP:0003074)1.63941304
150Increased CSF lactate (HP:0002490)1.63775412
151Abnormality of the ileum (HP:0001549)1.63058690
152Cystic liver disease (HP:0006706)1.62908959
153Osteomalacia (HP:0002749)1.62858590
154Blue irides (HP:0000635)1.62672532
155Sclerocornea (HP:0000647)1.61938399
156Broad-based gait (HP:0002136)1.61004531
157Decreased central vision (HP:0007663)1.59892639
158Gastrointestinal atresia (HP:0002589)1.58964096
159Postaxial hand polydactyly (HP:0001162)1.58957130
160Abnormality of glycine metabolism (HP:0010895)1.58946422
161Abnormality of serine family amino acid metabolism (HP:0010894)1.58946422
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.58676831
163Hypoplasia of the fovea (HP:0007750)1.58676831
164Anencephaly (HP:0002323)1.58565538
165Dyskinesia (HP:0100660)1.57761226
166Prominent metopic ridge (HP:0005487)1.57575419
167Adrenal hypoplasia (HP:0000835)1.57543599
168Male pseudohermaphroditism (HP:0000037)1.57089947
169Abnormality of the renal medulla (HP:0100957)1.55699016
170Nonprogressive disorder (HP:0003680)1.55618654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.00716950
2ERBB32.88803279
3SIK32.81972033
4TRIM282.81428623
5AKT32.63342603
6MKNK12.61963835
7WNK32.54158759
8MKNK22.48798142
9ACVR1B2.29944239
10SGK22.24371227
11TXK2.17559961
12MAP4K22.17356171
13VRK12.15033559
14SRPK12.12711744
15NEK62.12417718
16CASK2.02794960
17PLK41.97872206
18FRK1.97162861
19MAP3K141.96445673
20YES11.83294063
21PRPF4B1.82696729
22IRAK41.78131087
23GRK11.75478262
24BMPR21.73215795
25MAP2K71.66901212
26EPHA31.65863269
27CDK81.63174636
28TEC1.61810057
29NUAK11.57959409
30MAP3K41.56436534
31IRAK31.56105412
32BUB11.51707041
33FGFR21.49014147
34TRPM71.43195168
35STK391.37782199
36TAOK21.35537573
37MAPK131.33127687
38PLK21.30153928
39PLK31.29970884
40MAP3K121.29294340
41SGK31.29106579
42CCNB11.28166484
43OXSR11.26829419
44MUSK1.23704858
45STK161.20689624
46BRD41.19874445
47SGK2231.17258503
48SGK4941.17258503
49PAK31.14550266
50TNK21.13955186
51NEK91.09763415
52EIF2AK21.09702025
53TNIK1.07980424
54STK31.05654850
55BRSK11.03783226
56JAK31.00763365
57BTK1.00543166
58BRSK20.99964977
59FER0.99639847
60IKBKB0.98089676
61BMPR1B0.96370814
62CDK30.92457234
63INSRR0.92376939
64BCR0.92274080
65STK240.91476099
66TTK0.91192268
67ADRBK20.90053107
68CDC70.86725232
69RPS6KB10.85225698
70CSNK1G10.85048701
71NEK10.84803523
72TGFBR10.83557061
73ATR0.83421715
74NLK0.83347058
75CHUK0.83116702
76TAF10.82939807
77EIF2AK30.80964325
78PIK3CA0.77177892
79STK38L0.75388074
80PHKG10.74943453
81PHKG20.74943453
82WNK40.72733160
83MST40.71388994
84RPS6KA50.70400882
85IKBKE0.67986358
86IRAK10.67271933
87LATS10.66523059
88FGFR10.63783672
89CSNK1G30.63345949
90PASK0.63077410
91ATM0.61913546
92CAMKK20.61625452
93FGFR30.57856477
94EIF2AK10.57395074
95CSNK1G20.56283186
96WNK10.55559546
97CLK10.55153976
98VRK20.54803993
99TSSK60.53677469
100MYLK0.53108654
101RPS6KA60.52444778
102KIT0.52162052
103MAP2K30.51445722
104IRAK20.49216613
105PIM10.48424335
106CSF1R0.47612705
107MAP3K30.46322176
108GRK70.44139141
109CSNK1D0.43624190
110PINK10.42472708
111CSNK1A1L0.42189576
112RPS6KA40.40427310
113SGK10.39691237
114MAPK30.39566201
115SYK0.39518904
116PRKCE0.39359136
117PNCK0.39213855
118DYRK1A0.38658329
119FLT30.38358334
120CSNK2A10.38183554
121MAPKAPK50.37941611
122MAP2K60.37824920
123LYN0.37687291
124PLK10.36650055
125PRKCG0.36578346
126LCK0.36506557
127MAP4K10.36430427
128WEE10.34301170
129ITK0.34045169
130CSNK1A10.33898326
131DAPK10.33458561
132CHEK20.33055420
133TAOK30.32988900
134CHEK10.32661253
135PRKCH0.32293396
136EPHA40.31742840
137TLK10.31296775
138PTK2B0.30142488
139ABL10.30138121
140BCKDK0.29813042
141PRKDC0.28461217
142PRKCQ0.28127198
143RPS6KB20.26446043
144PRKAA10.26434057
145EGFR0.24720536
146PBK0.24639244

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14966416
2Homologous recombination_Homo sapiens_hsa034402.85808257
3Propanoate metabolism_Homo sapiens_hsa006402.62324956
4Protein export_Homo sapiens_hsa030602.40085445
5Fanconi anemia pathway_Homo sapiens_hsa034602.39369881
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35120774
7DNA replication_Homo sapiens_hsa030302.31837756
8Mismatch repair_Homo sapiens_hsa034302.28344095
9Basal transcription factors_Homo sapiens_hsa030222.25129249
10RNA degradation_Homo sapiens_hsa030182.21819599
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20527252
12RNA polymerase_Homo sapiens_hsa030202.18532988
13Non-homologous end-joining_Homo sapiens_hsa034502.10471623
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05973813
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03828935
16Base excision repair_Homo sapiens_hsa034102.03288645
17Spliceosome_Homo sapiens_hsa030401.98497658
18Selenocompound metabolism_Homo sapiens_hsa004501.96054585
19Butanoate metabolism_Homo sapiens_hsa006501.93453919
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81384968
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78987637
22Cell cycle_Homo sapiens_hsa041101.77360210
23Nucleotide excision repair_Homo sapiens_hsa034201.73475887
24Primary immunodeficiency_Homo sapiens_hsa053401.64728029
25mRNA surveillance pathway_Homo sapiens_hsa030151.59952400
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59208079
27Herpes simplex infection_Homo sapiens_hsa051681.56739905
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51180277
29Linoleic acid metabolism_Homo sapiens_hsa005911.51024415
30Caffeine metabolism_Homo sapiens_hsa002321.50590057
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50235185
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.47848823
33Ether lipid metabolism_Homo sapiens_hsa005651.46037601
34Steroid biosynthesis_Homo sapiens_hsa001001.35537239
35Hematopoietic cell lineage_Homo sapiens_hsa046401.31447337
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29114585
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24600307
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22332776
39Fatty acid elongation_Homo sapiens_hsa000621.17502788
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17390646
41Vitamin B6 metabolism_Homo sapiens_hsa007501.17232504
42Pyrimidine metabolism_Homo sapiens_hsa002401.15592669
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.15568266
44Allograft rejection_Homo sapiens_hsa053301.14852155
45Arachidonic acid metabolism_Homo sapiens_hsa005901.14727205
46Regulation of autophagy_Homo sapiens_hsa041401.13282221
47Measles_Homo sapiens_hsa051621.12302672
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11929310
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11587298
50Peroxisome_Homo sapiens_hsa041461.11487732
51Nitrogen metabolism_Homo sapiens_hsa009101.10934077
52RNA transport_Homo sapiens_hsa030131.09205805
53Phototransduction_Homo sapiens_hsa047441.08239600
54Type I diabetes mellitus_Homo sapiens_hsa049401.07552259
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06379141
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05851157
57Purine metabolism_Homo sapiens_hsa002301.03674835
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.97827978
59Tryptophan metabolism_Homo sapiens_hsa003800.97360610
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95668512
61N-Glycan biosynthesis_Homo sapiens_hsa005100.94919969
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94350247
63Graft-versus-host disease_Homo sapiens_hsa053320.93553439
64Legionellosis_Homo sapiens_hsa051340.91959669
65Influenza A_Homo sapiens_hsa051640.89648345
66Leishmaniasis_Homo sapiens_hsa051400.86418188
67Taste transduction_Homo sapiens_hsa047420.86076496
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84912268
69TNF signaling pathway_Homo sapiens_hsa046680.84773745
70Epstein-Barr virus infection_Homo sapiens_hsa051690.84136065
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83489200
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82837853
73Oxidative phosphorylation_Homo sapiens_hsa001900.82196780
74Shigellosis_Homo sapiens_hsa051310.79126849
75Serotonergic synapse_Homo sapiens_hsa047260.78067333
76Autoimmune thyroid disease_Homo sapiens_hsa053200.77814979
77Vitamin digestion and absorption_Homo sapiens_hsa049770.77192909
78Collecting duct acid secretion_Homo sapiens_hsa049660.76750919
79HTLV-I infection_Homo sapiens_hsa051660.76433660
80Hepatitis B_Homo sapiens_hsa051610.76045847
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75315739
82Proteasome_Homo sapiens_hsa030500.72391259
83Circadian rhythm_Homo sapiens_hsa047100.69598371
84One carbon pool by folate_Homo sapiens_hsa006700.69523078
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69432136
86p53 signaling pathway_Homo sapiens_hsa041150.68794502
87Circadian entrainment_Homo sapiens_hsa047130.68357653
88Fatty acid metabolism_Homo sapiens_hsa012120.67416034
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63286686
90Rheumatoid arthritis_Homo sapiens_hsa053230.63025368
91Other glycan degradation_Homo sapiens_hsa005110.61353090
92Nicotine addiction_Homo sapiens_hsa050330.61074760
93Prostate cancer_Homo sapiens_hsa052150.60172775
94Insulin secretion_Homo sapiens_hsa049110.59217485
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57462825
96beta-Alanine metabolism_Homo sapiens_hsa004100.55067228
97Morphine addiction_Homo sapiens_hsa050320.54888536
98Chemokine signaling pathway_Homo sapiens_hsa040620.54120448
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.53746714
100Thyroid cancer_Homo sapiens_hsa052160.53058265
101Lysine degradation_Homo sapiens_hsa003100.53050267
102Sphingolipid metabolism_Homo sapiens_hsa006000.53014769
103Asthma_Homo sapiens_hsa053100.52795626
104Olfactory transduction_Homo sapiens_hsa047400.52547361
105Metabolic pathways_Homo sapiens_hsa011000.51805444
106Sulfur metabolism_Homo sapiens_hsa009200.51419811
107MAPK signaling pathway_Homo sapiens_hsa040100.49948667
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49662722
109Mineral absorption_Homo sapiens_hsa049780.47784931
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47155590
111Fatty acid degradation_Homo sapiens_hsa000710.46626308
112Wnt signaling pathway_Homo sapiens_hsa043100.46553923
113Chemical carcinogenesis_Homo sapiens_hsa052040.46315014
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46039133
115Antigen processing and presentation_Homo sapiens_hsa046120.45840344
116Hedgehog signaling pathway_Homo sapiens_hsa043400.45762753
117ABC transporters_Homo sapiens_hsa020100.45173096
118TGF-beta signaling pathway_Homo sapiens_hsa043500.45099192
119MicroRNAs in cancer_Homo sapiens_hsa052060.44874130
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44766576
121Osteoclast differentiation_Homo sapiens_hsa043800.44145174
122Retinol metabolism_Homo sapiens_hsa008300.43694954
123Parkinsons disease_Homo sapiens_hsa050120.43345292
124T cell receptor signaling pathway_Homo sapiens_hsa046600.42175303
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41739271
126Pertussis_Homo sapiens_hsa051330.40165840
127FoxO signaling pathway_Homo sapiens_hsa040680.39736527
128Ribosome_Homo sapiens_hsa030100.38730264
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38382972
130Toxoplasmosis_Homo sapiens_hsa051450.38189538
131B cell receptor signaling pathway_Homo sapiens_hsa046620.37975007
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37529443
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37494451
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.37450810
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37411530
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.36998179
137Prolactin signaling pathway_Homo sapiens_hsa049170.36893244
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36821507
139Malaria_Homo sapiens_hsa051440.35630538
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.35558195
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35457034
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34785967
143Ovarian steroidogenesis_Homo sapiens_hsa049130.34546087
144Oocyte meiosis_Homo sapiens_hsa041140.34499154
145ErbB signaling pathway_Homo sapiens_hsa040120.34372286
146Acute myeloid leukemia_Homo sapiens_hsa052210.34165665
147Hepatitis C_Homo sapiens_hsa051600.34038478
148Long-term depression_Homo sapiens_hsa047300.33461809
149Pyruvate metabolism_Homo sapiens_hsa006200.32986956
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31352228
151Fat digestion and absorption_Homo sapiens_hsa049750.29992806
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26400710
153Huntingtons disease_Homo sapiens_hsa050160.22628260

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