PROS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.53001712
2drug catabolic process (GO:0042737)5.86925571
3blood coagulation, intrinsic pathway (GO:0007597)5.74794606
4axonemal dynein complex assembly (GO:0070286)4.98018109
5ethanol metabolic process (GO:0006067)4.88082757
6cellular glucuronidation (GO:0052695)4.82735126
7complement activation, alternative pathway (GO:0006957)4.66322008
8omega-hydroxylase P450 pathway (GO:0097267)4.55364512
9glucuronate metabolic process (GO:0019585)4.50150177
10uronic acid metabolic process (GO:0006063)4.50150177
11primary alcohol catabolic process (GO:0034310)4.34688705
12negative regulation of sterol transport (GO:0032372)4.31504027
13very-low-density lipoprotein particle assembly (GO:0034379)4.22085265
14cilium or flagellum-dependent cell motility (GO:0001539)4.21609131
15negative regulation of fibrinolysis (GO:0051918)4.21541631
16apoptotic cell clearance (GO:0043277)4.19905131
17* regulation of protein activation cascade (GO:2000257)4.18857999
18* peptidyl-glutamic acid carboxylation (GO:0017187)4.14229391
19* protein carboxylation (GO:0018214)4.14229391
20* regulation of complement activation (GO:0030449)4.10791802
21* negative regulation of coagulation (GO:0050819)4.08209152
22drug metabolic process (GO:0017144)3.99049877
23negative regulation of complement activation (GO:0045916)3.98730745
24* negative regulation of wound healing (GO:0061045)3.92782395
25low-density lipoprotein particle remodeling (GO:0034374)3.89303158
26negative regulation of humoral immune response (GO:0002921)3.82382892
27regulation of fibrinolysis (GO:0051917)3.78972807
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77975914
29intestinal cholesterol absorption (GO:0030299)3.67726408
30* regulation of humoral immune response (GO:0002920)3.67317745
31tyrosine metabolic process (GO:0006570)3.65223949
32alpha-linolenic acid metabolic process (GO:0036109)3.59631960
33urea metabolic process (GO:0019627)3.51467304
34urea cycle (GO:0000050)3.51467304
35polyketide metabolic process (GO:0030638)3.51123143
36doxorubicin metabolic process (GO:0044598)3.51123143
37daunorubicin metabolic process (GO:0044597)3.51123143
38L-phenylalanine metabolic process (GO:0006558)3.50457524
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.50457524
40negative regulation of lipase activity (GO:0060192)3.50025355
41cell adhesion mediated by integrin (GO:0033627)3.48698509
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.47794039
43L-phenylalanine catabolic process (GO:0006559)3.47794039
44basement membrane organization (GO:0071711)3.46692691
45plasma lipoprotein particle assembly (GO:0034377)3.45125485
46cilium movement (GO:0003341)3.41490161
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40620345
48positive regulation of extracellular matrix organization (GO:1903055)3.38549901
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.35840539
50motile cilium assembly (GO:0044458)3.34268353
51low-density lipoprotein particle clearance (GO:0034383)3.33653737
52plasma lipoprotein particle clearance (GO:0034381)3.32744239
53sulfur amino acid catabolic process (GO:0000098)3.31420086
54plasma lipoprotein particle organization (GO:0071827)3.31417327
55high-density lipoprotein particle remodeling (GO:0034375)3.28756276
56opsonization (GO:0008228)3.27883462
57vascular endothelial growth factor signaling pathway (GO:0038084)3.26739781
58bile acid biosynthetic process (GO:0006699)3.22299266
59response to mercury ion (GO:0046689)3.22208823
60positive regulation of blood coagulation (GO:0030194)3.21510411
61positive regulation of hemostasis (GO:1900048)3.21510411
62complement activation (GO:0006956)3.21276013
63oxidative demethylation (GO:0070989)3.20933912
64positive regulation of triglyceride lipase activity (GO:0061365)3.20736084
65positive regulation of lipoprotein lipase activity (GO:0051006)3.20736084
66collagen fibril organization (GO:0030199)3.20454199
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.20084700
68aminoglycoside antibiotic metabolic process (GO:0030647)3.18659740
69reverse cholesterol transport (GO:0043691)3.16258570
70hormone catabolic process (GO:0042447)3.16251989
71homocysteine metabolic process (GO:0050667)3.15756958
72protein-lipid complex subunit organization (GO:0071825)3.15169567
73regulation of apoptotic cell clearance (GO:2000425)3.14691210
74epoxygenase P450 pathway (GO:0019373)3.13945306
75nitrogen cycle metabolic process (GO:0071941)3.13871512
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13092754
77primary alcohol metabolic process (GO:0034308)3.11867349
78aromatic amino acid family catabolic process (GO:0009074)3.11740242
79phenylpropanoid metabolic process (GO:0009698)3.11471247
80regulation of lipoprotein metabolic process (GO:0050746)3.11324622
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07795330
82* fibrinolysis (GO:0042730)3.04317044
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03078712
84regulation of cholesterol storage (GO:0010885)3.03015602
85positive regulation of coagulation (GO:0050820)3.02886095
86positive regulation of wound healing (GO:0090303)3.02371166
87protein heterotrimerization (GO:0070208)3.02079282
88glyoxylate metabolic process (GO:0046487)3.01577845
89carnitine metabolic process (GO:0009437)3.01388980
90complement activation, classical pathway (GO:0006958)2.99211031
91negative regulation of lipid transport (GO:0032369)2.97750906
92* regulation of blood coagulation (GO:0030193)2.97407411
93protein activation cascade (GO:0072376)2.97326965
94phospholipid efflux (GO:0033700)2.94667421
95endodermal cell differentiation (GO:0035987)2.93293834
96regulation of triglyceride catabolic process (GO:0010896)2.89787388
97regulation of plasminogen activation (GO:0010755)2.88685577
98kynurenine metabolic process (GO:0070189)2.86555316
99phospholipid homeostasis (GO:0055091)2.82915573
100lipoprotein metabolic process (GO:0042157)2.82501994
101negative regulation of protein activation cascade (GO:2000258)2.82435325
102protein-lipid complex remodeling (GO:0034368)2.78805667
103macromolecular complex remodeling (GO:0034367)2.78805667
104plasma lipoprotein particle remodeling (GO:0034369)2.78805667
105tryptophan catabolic process (GO:0006569)2.78229117
106indole-containing compound catabolic process (GO:0042436)2.78229117
107indolalkylamine catabolic process (GO:0046218)2.78229117
108keratan sulfate catabolic process (GO:0042340)2.77853749
109tryptophan metabolic process (GO:0006568)2.72830782
110bile acid metabolic process (GO:0008206)2.72310710
111positive regulation of lipid catabolic process (GO:0050996)2.70811739
112positive regulation of p38MAPK cascade (GO:1900745)2.70794844
113glomerular basement membrane development (GO:0032836)2.70662662
114positive regulation of fatty acid oxidation (GO:0046321)2.70184539
115cysteine metabolic process (GO:0006534)2.69310632
116cholesterol efflux (GO:0033344)2.68421584
117regulation of cholesterol esterification (GO:0010872)2.67724228
118retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67655455
119triglyceride homeostasis (GO:0070328)2.67545039
120acylglycerol homeostasis (GO:0055090)2.67545039
121midgut development (GO:0007494)2.65561012
122amino-acid betaine metabolic process (GO:0006577)2.64958169
123collagen metabolic process (GO:0032963)2.63976623
124glomerular visceral epithelial cell development (GO:0072015)2.63462708
125cell migration involved in sprouting angiogenesis (GO:0002042)2.61248261
126regulation of fatty acid beta-oxidation (GO:0031998)2.60197614
127endothelial cell morphogenesis (GO:0001886)2.60158186
128acute-phase response (GO:0006953)2.59066029
129bile acid and bile salt transport (GO:0015721)2.57958110
130lysine metabolic process (GO:0006553)2.57955452
131lysine catabolic process (GO:0006554)2.57955452
132* negative regulation of blood coagulation (GO:0030195)2.57769843
133* negative regulation of hemostasis (GO:1900047)2.57769843
134blood vessel endothelial cell migration (GO:0043534)2.55430292
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.54832882
136multicellular organismal macromolecule metabolic process (GO:0044259)2.53559071
137skin morphogenesis (GO:0043589)2.53256959
138wound healing, spreading of epidermal cells (GO:0035313)2.53191793
139collagen catabolic process (GO:0030574)2.52272010
140lymph vessel development (GO:0001945)2.50170649
141regulation of cholesterol homeostasis (GO:2000188)2.47747050
142lymphangiogenesis (GO:0001946)2.47199666
143protein-lipid complex assembly (GO:0065005)2.47061321
144ethanol oxidation (GO:0006069)2.46972792
145cholesterol homeostasis (GO:0042632)2.46274502
146sterol homeostasis (GO:0055092)2.45875108
147negative regulation of cholesterol transport (GO:0032375)2.44909000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.40998726
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.64279559
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.28002756
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09224011
5TRIM28_21343339_ChIP-Seq_HEK293_Human4.06291568
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00004028
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.90685678
8CLOCK_20551151_ChIP-Seq_293T_Human3.44785619
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27180186
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.13465620
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94704974
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93691230
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68621679
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57615753
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45472376
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.21420005
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.14877867
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14330355
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12285486
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.08067979
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.07142610
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01139604
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.99259477
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86462456
25* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.83086194
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80787991
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77814587
28CJUN_26792858_Chip-Seq_BT549_Human1.76726149
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73670146
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.71709071
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69510030
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.68144257
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.67280263
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65923954
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.65084070
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64144741
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59487786
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.58465330
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58009349
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55600236
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.54153463
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50644322
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.50507054
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49449712
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49449712
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.49333881
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45345035
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.44862851
49TP53_18474530_ChIP-ChIP_U2OS_Human1.42926179
50* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37519580
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37427372
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.37296970
53GATA1_19941826_ChIP-Seq_K562_Human1.35922821
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35137544
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34807719
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.33996359
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.33521258
58* SOX2_20726797_ChIP-Seq_SW620_Human1.31896212
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31452071
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29768019
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26259411
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25907617
63* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23825219
64GATA1_22025678_ChIP-Seq_K562_Human1.23520641
65BRD4_25478319_ChIP-Seq_HGPS_Human1.23433086
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23273585
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23273585
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22973157
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21200386
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17023146
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17023146
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17023146
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16870879
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.16835832
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16554264
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16487343
77GATA2_19941826_ChIP-Seq_K562_Human1.15446785
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13845441
79* TP63_23658742_ChIP-Seq_EP156T_Human1.13359238
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12008250
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09412673
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09156824
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.07362174
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07089074
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06864863
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06034986
87FOXA1_25552417_ChIP-Seq_VCAP_Human1.04283138
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02163461
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01354438
90P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98638646
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98462365
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98024403
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97963950
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.97626523
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97567509
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.97364057
97TBX20_22328084_ChIP-Seq_HEART_Mouse0.97364057
98GATA4_25053715_ChIP-Seq_YYC3_Human0.96484163
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96435351
100AHR_22903824_ChIP-Seq_MCF-7_Human0.96137473
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95004315
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93258985
103* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89019356
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88498904
105ZNF263_19887448_ChIP-Seq_K562_Human0.88321324
106* UBF1/2_26484160_Chip-Seq_HMECs_Human0.88082913
107RACK7_27058665_Chip-Seq_MCF-7_Human0.87774083
108TP53_16413492_ChIP-PET_HCT116_Human0.87666370
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87612717
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87094943
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86716489
112ATF3_27146783_Chip-Seq_COLON_Human0.86247497
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86028763
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85544480
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.84769286
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84022391
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83850215
118CDX2_22108803_ChIP-Seq_LS180_Human0.83583050
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83493762
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.83439636
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83421435
122GATA6_25053715_ChIP-Seq_YYC3_Human0.82817122
123BCAT_22108803_ChIP-Seq_LS180_Human0.82621060
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82097483
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80790681
126VDR_24787735_ChIP-Seq_THP-1_Human0.80737543
127HNFA_21074721_ChIP-Seq_CACO-2_Human0.79261434
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.78895304
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76774796
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76189525
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76183107
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.76060351
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.75109923
134SMAD4_21799915_ChIP-Seq_A2780_Human0.75019338
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.74768875
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72109721
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72091003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.45673321
2MP0003705_abnormal_hypodermis_morpholog4.07913889
3MP0005275_abnormal_skin_tensile3.45537007
4MP0002139_abnormal_hepatobiliary_system3.30793127
5MP0005360_urolithiasis3.30156401
6MP0004272_abnormal_basement_membrane2.75724853
7MP0010368_abnormal_lymphatic_system2.71839042
8MP0005085_abnormal_gallbladder_physiolo2.65732512
9MP0005503_abnormal_tendon_morphology2.49957130
10MP0003868_abnormal_feces_composition2.48723132
11MP0005365_abnormal_bile_salt2.47462165
12MP0003191_abnormal_cellular_cholesterol2.41872673
13MP0003279_aneurysm2.41775347
14MP0009840_abnormal_foam_cell2.32834735
15MP0003252_abnormal_bile_duct2.26524580
16MP0005408_hypopigmentation2.24343020
17MP0002132_abnormal_respiratory_system2.16824620
18MP0003724_increased_susceptibility_to2.05793214
19MP0006054_spinal_hemorrhage2.05764108
20MP0009384_cardiac_valve_regurgitation2.00329295
21MP0001958_emphysema1.94765877
22MP0008875_abnormal_xenobiotic_pharmacok1.93339015
23MP0003566_abnormal_cell_adhesion1.85019179
24MP0010329_abnormal_lipoprotein_level1.80241158
25MP0005023_abnormal_wound_healing1.73758868
26MP0001879_abnormal_lymphatic_vessel1.71381739
27MP0009697_abnormal_copulation1.68298534
28MP0002060_abnormal_skin_morphology1.64372971
29MP0003300_gastrointestinal_ulcer1.64183831
30MP0009780_abnormal_chondrocyte_physiolo1.62977928
31MP0003656_abnormal_erythrocyte_physiolo1.60130578
32MP0003806_abnormal_nucleotide_metabolis1.59056656
33MP0002254_reproductive_system_inflammat1.49224296
34MP0005058_abnormal_lysosome_morphology1.48421893
35MP0002876_abnormal_thyroid_physiology1.46941620
36MP0001661_extended_life_span1.42367087
37MP0005623_abnormal_meninges_morphology1.41653826
38MP0000566_synostosis1.37080201
39MP0002295_abnormal_pulmonary_circulatio1.36536504
40MP0010352_gastrointestinal_tract_polyps1.35816572
41MP0003950_abnormal_plasma_membrane1.32109363
42MP0001542_abnormal_bone_strength1.30719615
43MP0000767_abnormal_smooth_muscle1.28989234
44MP0001533_abnormal_skeleton_physiology1.27303546
45MP0009053_abnormal_anal_canal1.26802491
46MP0005409_darkened_coat_color1.23180563
47MP0002138_abnormal_hepatobiliary_system1.23087412
48MP0000609_abnormal_liver_physiology1.21574278
49MP0004084_abnormal_cardiac_muscle1.18512907
50MP0005332_abnormal_amino_acid1.18419432
51MP0005508_abnormal_skeleton_morphology1.14830927
52MP0003091_abnormal_cell_migration1.14657707
53MP0000343_altered_response_to1.12573895
54MP0005670_abnormal_white_adipose1.12265324
55MP0004019_abnormal_vitamin_homeostasis1.09068154
56MP0003195_calcinosis1.07164307
57MP0005164_abnormal_response_to1.05184416
58MP0003436_decreased_susceptibility_to1.04807451
59MP0001243_abnormal_dermal_layer1.04054001
60MP0005167_abnormal_blood-brain_barrier1.03891987
61MP0005390_skeleton_phenotype1.00854434
62MP0002168_other_aberrant_phenotype0.99423517
63MP0003453_abnormal_keratinocyte_physiol0.97741794
64MP0005319_abnormal_enzyme/_coenzyme0.96827902
65MP0002118_abnormal_lipid_homeostasis0.96394675
66MP0002896_abnormal_bone_mineralization0.95919866
67MP0005187_abnormal_penis_morphology0.95439064
68MP0002998_abnormal_bone_remodeling0.93883256
69MP0004883_abnormal_blood_vessel0.93647511
70MP0006138_congestive_heart_failure0.93646463
71MP0006082_CNS_inflammation0.92843116
72MP0000249_abnormal_blood_vessel0.92497577
73* MP0001915_intracranial_hemorrhage0.92262020
74MP0004130_abnormal_muscle_cell0.91690857
75MP0005083_abnormal_biliary_tract0.91456080
76MP0003303_peritoneal_inflammation0.91367363
77MP0003011_delayed_dark_adaptation0.90973578
78MP0001666_abnormal_nutrient_absorption0.90210363
79MP0004185_abnormal_adipocyte_glucose0.89937469
80MP0002877_abnormal_melanocyte_morpholog0.87535331
81MP0005171_absent_coat_pigmentation0.87520455
82MP0009764_decreased_sensitivity_to0.86276330
83MP0003075_altered_response_to0.86123176
84MP0005257_abnormal_intraocular_pressure0.85865411
85MP0002282_abnormal_trachea_morphology0.85728064
86* MP0000598_abnormal_liver_morphology0.82777876
87MP0003136_yellow_coat_color0.81562463
88* MP0009763_increased_sensitivity_to0.81480881
89MP0005076_abnormal_cell_differentiation0.81347849
90MP0008775_abnormal_heart_ventricle0.81137274
91MP0001851_eye_inflammation0.81078950
92* MP0002128_abnormal_blood_circulation0.80744860
93MP0004947_skin_inflammation0.79234558
94MP0010234_abnormal_vibrissa_follicle0.78814555
95MP0005666_abnormal_adipose_tissue0.78114404
96MP0009643_abnormal_urine_homeostasis0.77817163
97MP0003045_fibrosis0.77320641
98MP0002108_abnormal_muscle_morphology0.76943746
99MP0003690_abnormal_glial_cell0.76519308
100MP0005636_abnormal_mineral_homeostasis0.76307467
101MP0002933_joint_inflammation0.75422702
102MP0009278_abnormal_bone_marrow0.75001210
103MP0005595_abnormal_vascular_smooth0.74997488
104MP0001614_abnormal_blood_vessel0.74990274
105MP0005165_increased_susceptibility_to0.74333709
106MP0008004_abnormal_stomach_pH0.74038111
107MP0003448_altered_tumor_morphology0.73963178
108MP0002796_impaired_skin_barrier0.73463873
109MP0004036_abnormal_muscle_relaxation0.73076804
110MP0000013_abnormal_adipose_tissue0.73009092
111MP0002166_altered_tumor_susceptibility0.72911795
112MP0003828_pulmonary_edema0.72369992
113MP0008469_abnormal_protein_level0.72079164
114MP0005395_other_phenotype0.71667606
115MP0005584_abnormal_enzyme/coenzyme_acti0.71554257
116MP0001764_abnormal_homeostasis0.71372769
117MP0002971_abnormal_brown_adipose0.70127546
118MP0002089_abnormal_postnatal_growth/wei0.70022307
119MP0005464_abnormal_platelet_physiology0.69442107
120* MP0009642_abnormal_blood_homeostasis0.68882984
121MP0002419_abnormal_innate_immunity0.67462242
122MP0005248_abnormal_Harderian_gland0.66326432
123MP0005197_abnormal_uvea_morphology0.65850154
124MP0002115_abnormal_skeleton_extremities0.65699492
125MP0005166_decreased_susceptibility_to0.65016779
126MP0003186_abnormal_redox_activity0.64727199
127MP0002135_abnormal_kidney_morphology0.64638862
128MP0000733_abnormal_muscle_development0.63855306
129MP0000465_gastrointestinal_hemorrhage0.63583314
130MP0002136_abnormal_kidney_physiology0.63009337
131MP0005330_cardiomyopathy0.62124016
132MP0000604_amyloidosis0.61932323
133MP0003941_abnormal_skin_development0.61300829
134MP0005376_homeostasis/metabolism_phenot0.60156257
135MP0000467_abnormal_esophagus_morphology0.59314598
136MP0002972_abnormal_cardiac_muscle0.56698947
137MP0000858_altered_metastatic_potential0.56083526
138MP0004215_abnormal_myocardial_fiber0.55252084
139MP0001984_abnormal_olfaction0.53066905
140MP0000751_myopathy0.53010921
141MP0001756_abnormal_urination0.52473791
142MP0005451_abnormal_body_composition0.49280255

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.46483445
2Protrusio acetabuli (HP:0003179)5.37993220
3Deep venous thrombosis (HP:0002625)5.06861068
4Complement deficiency (HP:0004431)5.04851640
5Systemic lupus erythematosus (HP:0002725)4.95318253
6Abnormal respiratory epithelium morphology (HP:0012253)4.91948563
7Abnormal respiratory motile cilium morphology (HP:0005938)4.91948563
8Premature rupture of membranes (HP:0001788)4.89779270
9Abnormal ciliary motility (HP:0012262)4.81842085
10Abnormal respiratory motile cilium physiology (HP:0012261)4.80418491
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.63937980
12Absent/shortened dynein arms (HP:0200106)4.63937980
13Rhinitis (HP:0012384)4.63776217
14Conjugated hyperbilirubinemia (HP:0002908)4.55923706
15Abnormality of complement system (HP:0005339)4.17034047
16Menorrhagia (HP:0000132)4.15961186
17Cerebral aneurysm (HP:0004944)4.12417226
18Glomerulonephritis (HP:0000099)4.02525968
19Aortic dissection (HP:0002647)3.82888296
20Peritonitis (HP:0002586)3.78876964
21Aortic aneurysm (HP:0004942)3.72928968
22Xanthomatosis (HP:0000991)3.70868402
23Broad metatarsal (HP:0001783)3.60770488
24Spontaneous abortion (HP:0005268)3.55059330
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.48935520
26Gingival bleeding (HP:0000225)3.48382469
27Increased mean platelet volume (HP:0011877)3.32291075
28Intrahepatic cholestasis (HP:0001406)3.32207270
29Shallow orbits (HP:0000586)3.31398291
30Myocardial infarction (HP:0001658)3.26500469
31Ankle contracture (HP:0006466)3.19214153
32Nephritis (HP:0000123)3.15886744
33Hypoalphalipoproteinemia (HP:0003233)3.06973716
34Prolonged partial thromboplastin time (HP:0003645)3.04049696
35Abnormality of the common coagulation pathway (HP:0010990)3.00307081
36* Purpura (HP:0000979)2.97338071
37Cervical subluxation (HP:0003308)2.95124064
38Mitral valve prolapse (HP:0001634)2.89842991
39Soft skin (HP:0000977)2.88473695
40Abnormal platelet volume (HP:0011876)2.86506458
41Hyperlipoproteinemia (HP:0010980)2.85226860
42Joint hemorrhage (HP:0005261)2.83707371
43Chronic bronchitis (HP:0004469)2.83294430
44Atrophic scars (HP:0001075)2.82496358
45Hematochezia (HP:0002573)2.77651093
46Acanthocytosis (HP:0001927)2.77172635
47Mitral stenosis (HP:0001718)2.77067386
48Bronchiectasis (HP:0002110)2.75737959
49Nasal polyposis (HP:0100582)2.74399030
50Esophageal varix (HP:0002040)2.72997289
51Hypolipoproteinemia (HP:0010981)2.66310282
52Osteolytic defects of the hand bones (HP:0009699)2.65199199
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.65199199
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63734237
55Vascular tortuosity (HP:0004948)2.62586489
56Rickets (HP:0002748)2.61556456
57Arterial tortuosity (HP:0005116)2.59207588
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58380691
59Blue sclerae (HP:0000592)2.57872588
60Vertebral compression fractures (HP:0002953)2.53669878
61Nonimmune hydrops fetalis (HP:0001790)2.53364768
62Abnormality of the intrinsic pathway (HP:0010989)2.50402461
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.49757752
64Prolonged bleeding time (HP:0003010)2.49735127
65Hypobetalipoproteinemia (HP:0003563)2.49341249
66Dilatation of the ascending aorta (HP:0005111)2.49194496
67Aneurysm (HP:0002617)2.49179363
68Cardiovascular calcification (HP:0011915)2.48690295
69Abnormality of the nasal mucosa (HP:0000433)2.45120308
70Epistaxis (HP:0000421)2.42686300
71Steatorrhea (HP:0002570)2.41190484
72Follicular hyperkeratosis (HP:0007502)2.37503483
73Poikilocytosis (HP:0004447)2.36852104
74Increased connective tissue (HP:0009025)2.32877712
75Recurrent gram-negative bacterial infections (HP:0005420)2.32361244
76Epidermoid cyst (HP:0200040)2.31445710
77Osteomalacia (HP:0002749)2.29590859
78Bladder diverticulum (HP:0000015)2.24576347
79Male infertility (HP:0003251)2.24180543
80Skin nodule (HP:0200036)2.23879438
81Striae distensae (HP:0001065)2.20261510
82Impaired platelet aggregation (HP:0003540)2.19220605
83Abnormal platelet function (HP:0011869)2.19220605
84Abnormal delivery (HP:0001787)2.16399303
85Spondylolisthesis (HP:0003302)2.12675671
86Hydroxyprolinuria (HP:0003080)2.12268445
87Abnormality of proline metabolism (HP:0010907)2.12268445
88Wrist flexion contracture (HP:0001239)2.10815952
89Biconcave vertebral bodies (HP:0004586)2.10306501
90Alopecia of scalp (HP:0002293)2.09907317
91Fragile skin (HP:0001030)2.09538030
92Lymphangioma (HP:0100764)2.09530967
93Polycythemia (HP:0001901)2.09122332
94Wormian bones (HP:0002645)2.08755865
95Ectopia lentis (HP:0001083)2.07652560
96Arthropathy (HP:0003040)2.04640600
97Flat acetabular roof (HP:0003180)2.04297164
98Genu recurvatum (HP:0002816)2.04115587
99Hypercholesterolemia (HP:0003124)2.02452532
100Hyperammonemia (HP:0001987)2.02118632
101Focal segmental glomerulosclerosis (HP:0000097)2.01005681
102Abnormality of carpal bone ossification (HP:0006257)2.00530879
103Infertility (HP:0000789)1.97904662
104Dysostosis multiplex (HP:0000943)1.97619877
105Abnormality of the peritoneum (HP:0002585)1.96656298
106Hypoglycemic coma (HP:0001325)1.95733196
107Hepatocellular carcinoma (HP:0001402)1.95542882
108Hypophosphatemic rickets (HP:0004912)1.94523685
109Vascular calcification (HP:0004934)1.94175724
110Mucopolysacchariduria (HP:0008155)1.92543628
111Urinary glycosaminoglycan excretion (HP:0003541)1.92543628
112Disproportionate tall stature (HP:0001519)1.91492347
113Camptodactyly of toe (HP:0001836)1.89563845
114Abnormal cartilage morphology (HP:0002763)1.88109380
115Amyloidosis (HP:0011034)1.87636050
116Abnormality of pyrimidine metabolism (HP:0004353)1.86692881
117Vacuolated lymphocytes (HP:0001922)1.86177082
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85949152
119Spinal rigidity (HP:0003306)1.85388763
120Conjunctival telangiectasia (HP:0000524)1.83546383
121Hemorrhage of the eye (HP:0011885)1.82146088
122Axonal loss (HP:0003447)1.81815407
123Type 1 muscle fiber predominance (HP:0003803)1.81449578
124Turricephaly (HP:0000262)1.80964960
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.80927151
126Back pain (HP:0003418)1.80842992
127Mesangial abnormality (HP:0001966)1.80760520
128Spastic diplegia (HP:0001264)1.80736586
129Spontaneous hematomas (HP:0007420)1.78863982
130Bifid scrotum (HP:0000048)1.78722026
131Generalized aminoaciduria (HP:0002909)1.77666880
132Hyperextensible skin (HP:0000974)1.76034367
133Atelectasis (HP:0100750)1.74869523
134Recurrent otitis media (HP:0000403)1.73537579
135Abnormality of polysaccharide metabolism (HP:0011012)1.72904450
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72904450
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72904450
138Tetraparesis (HP:0002273)1.72449322
139Fat malabsorption (HP:0002630)1.72236368
140Increased cerebral lipofuscin (HP:0011813)1.71511517
141Abnormality of the Achilles tendon (HP:0005109)1.71053934
142Recurrent sinusitis (HP:0011108)1.66136398
143Cholecystitis (HP:0001082)1.63730184
144Abnormal gallbladder physiology (HP:0012438)1.63730184
145Abnormality of the acetabulum (HP:0003170)1.62479994
146Blue irides (HP:0000635)1.62025034
147Abnormal tarsal ossification (HP:0008369)1.60140565
148* Thrombophlebitis (HP:0004418)1.53898946
149Hyperbilirubinemia (HP:0002904)1.50479795
150Abnormal hand bone ossification (HP:0010660)1.50146082
151Abnormal ossification of hand bones (HP:0005921)1.48907020
152Joint swelling (HP:0001386)1.47004012
153Occipital encephalocele (HP:0002085)1.46359274
154Abnormality of methionine metabolism (HP:0010901)1.44864231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.45371481
2ERN13.78591881
3KDR3.11772612
4TRIB33.01918817
5MST42.83165015
6TIE12.64764194
7PKN22.61320425
8SIK12.50467309
9FGFR42.45810183
10PDGFRA2.35368496
11DDR22.21110306
12RIPK12.19122277
13MAP3K22.09429893
14TTN2.04473590
15EPHA32.00973762
16LATS11.94752436
17LMTK21.92593188
18NEK91.88904812
19MST1R1.88722615
20EIF2AK11.86660936
21TYK21.86591929
22PTK61.75523427
23BCR1.70242029
24ICK1.69256695
25CAMK1D1.68811804
26STK241.61170319
27EPHB11.60774114
28EPHB21.58888871
29JAK11.52520021
30MET1.52224263
31PAK41.47314563
32FRK1.47024939
33TGFBR11.47017063
34BCKDK1.46929336
35FER1.43114937
36MAP3K31.36194731
37BRSK21.33742416
38NTRK11.29898929
39STK101.19787723
40LRRK21.19230522
41FLT31.18613902
42CDK61.15695855
43TBK11.15505139
44BMX1.14395787
45MAP3K121.14221949
46FGFR21.12320705
47LATS21.08689295
48EPHA21.08064943
49PTK21.07880941
50PAK21.07849288
51MAP3K61.07504018
52PDK21.04995889
53MAPK151.04918913
54FGFR31.04883420
55CSF1R1.04703476
56STK31.01012222
57BLK0.99171129
58CSK0.98292915
59MKNK20.97482679
60MAP2K30.96940454
61TRPM70.93186440
62RPS6KA40.92393915
63FGFR10.89744370
64ERBB40.88500196
65PDPK10.87926069
66PDGFRB0.87568786
67TAOK20.84904033
68JAK20.84502309
69CAMK1G0.83121027
70STK38L0.81751240
71MOS0.81578812
72GSK3A0.80535666
73KIT0.80027145
74PRKACG0.78742731
75PIK3CG0.77421351
76MAP3K50.76724913
77MAPKAPK30.75845823
78JAK30.75741388
79ABL20.74838986
80PTK2B0.71365768
81IGF1R0.71332954
82SCYL20.68463714
83NLK0.66757589
84NTRK30.66410612
85MAP2K10.65873206
86MTOR0.64270680
87ERBB30.63007541
88MYLK0.62247521
89MAPK120.59480908
90RET0.55666398
91ILK0.54272099
92EGFR0.53447639
93INSRR0.52615942
94ZAP700.52551517
95CDC42BPA0.51968317
96INSR0.50577985
97MAP3K140.50313085
98MAPK70.49150986
99MAPK110.49139944
100MAP3K10.48969018
101STK380.48962992
102DYRK1B0.48929395
103ROCK20.47511221
104MAP3K70.47380775
105PRKD10.46052799
106ERBB20.45677597
107KSR20.45377753
108IKBKB0.44108480
109MAP3K100.43877427
110YES10.42327112
111PRKAA20.42308551
112CHUK0.41844654
113MAP2K20.40071538
114PRKG10.39799654
115PRKG20.39760975
116AKT30.38669516
117HCK0.38628818
118ABL10.37869646
119PIK3CA0.37482547
120SGK30.37421396
121EEF2K0.37410661
122MUSK0.36308785
123ROCK10.36304385
124OBSCN0.36199106
125PRKCE0.34568020
126MAP3K110.34428642
127PRKCH0.34387442
128SGK4940.34338056
129SGK2230.34338056
130MATK0.34115452
131DMPK0.34008370
132CAMKK20.33893735
133PAK30.33131150
134CAMK2G0.32283008
135SGK20.31532345
136PIM20.30997809
137BMPR20.29862196
138SRC0.29615007
139NUAK10.27708783
140MAPKAPK20.27417294

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.71873101
2* Complement and coagulation cascades_Homo sapiens_hsa046103.58411243
3Staphylococcus aureus infection_Homo sapiens_hsa051503.49025339
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.48783249
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59379475
6Arginine biosynthesis_Homo sapiens_hsa002202.50631424
7Caffeine metabolism_Homo sapiens_hsa002322.44646978
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19099678
9Fatty acid degradation_Homo sapiens_hsa000712.07887548
10PPAR signaling pathway_Homo sapiens_hsa033201.95049972
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94831545
12ECM-receptor interaction_Homo sapiens_hsa045121.93091140
13Tryptophan metabolism_Homo sapiens_hsa003801.91602128
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.74811043
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58058084
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57881145
17Chemical carcinogenesis_Homo sapiens_hsa052041.51109347
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49913421
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47981391
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46117048
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40452491
22Linoleic acid metabolism_Homo sapiens_hsa005911.40324432
23Fatty acid metabolism_Homo sapiens_hsa012121.39376617
24Malaria_Homo sapiens_hsa051441.36523677
25Peroxisome_Homo sapiens_hsa041461.29074692
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.29012027
27Histidine metabolism_Homo sapiens_hsa003401.27858932
28Other glycan degradation_Homo sapiens_hsa005111.22483076
29Focal adhesion_Homo sapiens_hsa045101.22314468
30Bile secretion_Homo sapiens_hsa049761.21610361
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.18424386
32Prion diseases_Homo sapiens_hsa050201.18220658
33Amoebiasis_Homo sapiens_hsa051461.15158786
34Lysosome_Homo sapiens_hsa041421.13543953
35Retinol metabolism_Homo sapiens_hsa008301.12113247
36Propanoate metabolism_Homo sapiens_hsa006401.11722834
37Starch and sucrose metabolism_Homo sapiens_hsa005001.07915017
38Selenocompound metabolism_Homo sapiens_hsa004501.07874126
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.06438720
40beta-Alanine metabolism_Homo sapiens_hsa004101.05339711
41Arachidonic acid metabolism_Homo sapiens_hsa005901.04662069
42ABC transporters_Homo sapiens_hsa020101.00204238
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99290799
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95450347
45Adherens junction_Homo sapiens_hsa045200.93141667
46Phenylalanine metabolism_Homo sapiens_hsa003600.91613901
47Pertussis_Homo sapiens_hsa051330.89022950
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88470669
49Proteoglycans in cancer_Homo sapiens_hsa052050.85404807
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85092746
51Butanoate metabolism_Homo sapiens_hsa006500.84906172
52Small cell lung cancer_Homo sapiens_hsa052220.83797047
53Lysine degradation_Homo sapiens_hsa003100.81861808
54Fat digestion and absorption_Homo sapiens_hsa049750.81582000
55Tyrosine metabolism_Homo sapiens_hsa003500.80428159
56Vitamin digestion and absorption_Homo sapiens_hsa049770.80186854
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79776435
58Protein digestion and absorption_Homo sapiens_hsa049740.78174836
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77926678
60Vitamin B6 metabolism_Homo sapiens_hsa007500.73287008
61Arginine and proline metabolism_Homo sapiens_hsa003300.68094821
62Toxoplasmosis_Homo sapiens_hsa051450.66142793
63Insulin resistance_Homo sapiens_hsa049310.63363253
64Folate biosynthesis_Homo sapiens_hsa007900.63136889
65Biosynthesis of amino acids_Homo sapiens_hsa012300.61076742
66Carbon metabolism_Homo sapiens_hsa012000.59693252
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59397943
68Leishmaniasis_Homo sapiens_hsa051400.59373449
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.59268338
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58715747
71TGF-beta signaling pathway_Homo sapiens_hsa043500.58643716
72Legionellosis_Homo sapiens_hsa051340.58099123
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.57645458
74Renin-angiotensin system_Homo sapiens_hsa046140.56771947
75Fatty acid elongation_Homo sapiens_hsa000620.55654261
76Phagosome_Homo sapiens_hsa041450.54472414
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54201692
78Pyruvate metabolism_Homo sapiens_hsa006200.54165134
79Osteoclast differentiation_Homo sapiens_hsa043800.54054731
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53985484
81Sulfur metabolism_Homo sapiens_hsa009200.53455962
82Bladder cancer_Homo sapiens_hsa052190.53240767
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53038613
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52594158
85Fatty acid biosynthesis_Homo sapiens_hsa000610.48738835
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47247459
87Steroid biosynthesis_Homo sapiens_hsa001000.45355784
88Glutathione metabolism_Homo sapiens_hsa004800.45013604
89Sphingolipid metabolism_Homo sapiens_hsa006000.44414152
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44131367
91TNF signaling pathway_Homo sapiens_hsa046680.42279393
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.40714267
93Pancreatic cancer_Homo sapiens_hsa052120.39584538
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38129172
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38047672
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37363468
97Platelet activation_Homo sapiens_hsa046110.36964678
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35811806
99Glycerolipid metabolism_Homo sapiens_hsa005610.35043931
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33514647
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33463865
102Galactose metabolism_Homo sapiens_hsa000520.33258567
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33253431
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33226842
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.32629859
106Chronic myeloid leukemia_Homo sapiens_hsa052200.32470702
107Pentose phosphate pathway_Homo sapiens_hsa000300.32189916
108Metabolic pathways_Homo sapiens_hsa011000.31917440
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30461546
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29431302
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.29181471
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28749129
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28677055
114Fructose and mannose metabolism_Homo sapiens_hsa000510.27800888
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26449635
116Dilated cardiomyopathy_Homo sapiens_hsa054140.25339695
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25055521
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24244576
119Circadian rhythm_Homo sapiens_hsa047100.19565624
120Mineral absorption_Homo sapiens_hsa049780.18125876
121One carbon pool by folate_Homo sapiens_hsa006700.14526512
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.12576341
123Tight junction_Homo sapiens_hsa045300.12515396
124AMPK signaling pathway_Homo sapiens_hsa041520.09754318
125N-Glycan biosynthesis_Homo sapiens_hsa005100.08994080
126Choline metabolism in cancer_Homo sapiens_hsa052310.04369678
127Thyroid hormone synthesis_Homo sapiens_hsa049180.03865617

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