PROP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.45096077
2daunorubicin metabolic process (GO:0044597)6.45096077
3polyketide metabolic process (GO:0030638)6.45096077
4positive regulation of cellular amide metabolic process (GO:0034250)4.40942912
5superoxide anion generation (GO:0042554)4.34327479
6negative regulation of mast cell activation (GO:0033004)4.23034273
7detection of molecule of bacterial origin (GO:0032490)4.19514432
8regulation of activation of Janus kinase activity (GO:0010533)3.90817858
9aminoglycoside antibiotic metabolic process (GO:0030647)3.79261634
10mesenchymal cell differentiation involved in kidney development (GO:0072161)3.66832925
11mesenchymal cell differentiation involved in renal system development (GO:2001012)3.66832925
12DNA strand renaturation (GO:0000733)3.64237330
13response to pheromone (GO:0019236)3.56146911
14positive regulation of uterine smooth muscle contraction (GO:0070474)3.45131046
15behavioral response to nicotine (GO:0035095)3.40225868
16detection of external biotic stimulus (GO:0098581)3.26524851
17histamine secretion (GO:0001821)3.20631887
18energy homeostasis (GO:0097009)3.14649363
19detection of other organism (GO:0098543)3.10561019
20regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10129578
21detection of bacterium (GO:0016045)3.00367807
22positive regulation of heat generation (GO:0031652)2.97601480
23cellular response to exogenous dsRNA (GO:0071360)2.93284180
24detection of biotic stimulus (GO:0009595)2.90375522
25natural killer cell activation involved in immune response (GO:0002323)2.84094182
26nucleotide transmembrane transport (GO:1901679)2.83957482
27response to host immune response (GO:0052572)2.82946590
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82946590
29ganglion development (GO:0061548)2.80420103
30cellular anion homeostasis (GO:0030002)2.79253137
31adenosine metabolic process (GO:0046085)2.77851393
32positive regulation of protein sumoylation (GO:0033235)2.75356153
33positive regulation of interleukin-1 beta secretion (GO:0050718)2.74167795
34auditory receptor cell stereocilium organization (GO:0060088)2.68576391
35response to peptidoglycan (GO:0032494)2.67886107
36extracellular regulation of signal transduction (GO:1900115)2.67731685
37extracellular negative regulation of signal transduction (GO:1900116)2.67731685
38histamine transport (GO:0051608)2.66953797
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65828421
40startle response (GO:0001964)2.65823941
41dentate gyrus development (GO:0021542)2.65097646
42dendritic cell chemotaxis (GO:0002407)2.63874480
43superoxide metabolic process (GO:0006801)2.63571462
44inner ear receptor stereocilium organization (GO:0060122)2.63283005
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61395699
46positive regulation by organism of defense response of other organism involved in symbiotic interact2.61395699
47modulation by symbiont of host immune response (GO:0052553)2.61395699
48positive regulation by symbiont of host defense response (GO:0052509)2.61395699
49modulation by symbiont of host defense response (GO:0052031)2.61395699
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61395699
51positive regulation of antigen processing and presentation (GO:0002579)2.58885163
52interferon-gamma production (GO:0032609)2.57672530
53cerebral cortex radially oriented cell migration (GO:0021799)2.57319311
54regulation of fever generation (GO:0031620)2.57237483
55dendritic cell migration (GO:0036336)2.55078085
56regulation of uterine smooth muscle contraction (GO:0070472)2.52595460
57regulation of interleukin-8 secretion (GO:2000482)2.51509509
58positive regulation of interleukin-1 secretion (GO:0050716)2.47936342
59cytochrome complex assembly (GO:0017004)2.45660004
60mannosylation (GO:0097502)2.44911362
61poly(A)+ mRNA export from nucleus (GO:0016973)2.39955003
62tRNA methylation (GO:0030488)2.38062974
63regulation of interleukin-1 beta secretion (GO:0050706)2.38001497
64G-protein coupled receptor internalization (GO:0002031)2.36095510
65positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.35452057
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.35452057
67prostate gland growth (GO:0060736)2.35198487
68cell differentiation involved in metanephros development (GO:0072202)2.35077069
69protein heterotetramerization (GO:0051290)2.34932981
70positive regulation of interleukin-17 production (GO:0032740)2.34467409
71drinking behavior (GO:0042756)2.34439404
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34364816
73eosinophil chemotaxis (GO:0048245)2.34124873
74developmental pigmentation (GO:0048066)2.32981657
75positive regulation of monocyte chemotaxis (GO:0090026)2.30410175
76estrogen biosynthetic process (GO:0006703)2.29819303
77DNA catabolic process, exonucleolytic (GO:0000738)2.29364124
78regulation of cellular extravasation (GO:0002691)2.29324914
79positive regulation of defense response to virus by host (GO:0002230)2.28558621
80mesenchymal cell differentiation (GO:0048762)2.28209207
81positive regulation of type 2 immune response (GO:0002830)2.27846036
82response to host defenses (GO:0052200)2.27763051
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27763051
84response to host (GO:0075136)2.27763051
85negative regulation of homotypic cell-cell adhesion (GO:0034111)2.27340388
86positive regulation of T cell migration (GO:2000406)2.26929417
87macrophage activation (GO:0042116)2.26865326
88regulation of timing of cell differentiation (GO:0048505)2.25697196
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.25060774
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25051731
91postsynaptic membrane organization (GO:0001941)2.24507200
92regulation of antigen processing and presentation (GO:0002577)2.24412822
93G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.23098445
94lipoxygenase pathway (GO:0019372)2.22670446
95negative regulation of meiosis (GO:0045835)2.22219906
96regulation of mitotic spindle checkpoint (GO:1903504)2.21276864
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.21276864
98I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.21264642
99regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21205734
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.20242427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.09844185
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96354719
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80389455
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79688378
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.63409037
6EZH2_22144423_ChIP-Seq_EOC_Human2.54999900
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52768398
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.31127262
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.08363450
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06725593
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05903304
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04165993
13P300_19829295_ChIP-Seq_ESCs_Human2.01963143
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.95629348
15PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95104785
16NFE2_27457419_Chip-Seq_LIVER_Mouse1.95038334
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.93009595
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.88084625
19STAT3_18555785_Chip-Seq_ESCs_Mouse1.87974336
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.86189107
21E2F1_18555785_Chip-Seq_ESCs_Mouse1.86142953
22P53_22387025_ChIP-Seq_ESCs_Mouse1.85400330
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81876757
24SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81606727
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80469935
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76583049
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76547279
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.76525592
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.75926422
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74088781
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73515427
32IGF1R_20145208_ChIP-Seq_DFB_Human1.72787805
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72390683
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.71241225
35NMYC_18555785_Chip-Seq_ESCs_Mouse1.69240850
36RNF2_27304074_Chip-Seq_NSC_Mouse1.65897108
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65000390
38CMYC_18555785_Chip-Seq_ESCs_Mouse1.64952193
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64932611
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.64872996
41SOX2_18555785_Chip-Seq_ESCs_Mouse1.60231187
42TAF15_26573619_Chip-Seq_HEK293_Human1.58963583
43RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58963223
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57377952
45P300_18555785_Chip-Seq_ESCs_Mouse1.56324093
46PU1_27457419_Chip-Seq_LIVER_Mouse1.53508249
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52634844
48ZFX_18555785_Chip-Seq_ESCs_Mouse1.50859926
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.49837729
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49620695
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.49507547
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49456256
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48668791
54SMAD4_21799915_ChIP-Seq_A2780_Human1.47119262
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45430743
56FUS_26573619_Chip-Seq_HEK293_Human1.44842615
57EWS_26573619_Chip-Seq_HEK293_Human1.44393991
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.40660511
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39261823
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36785051
61ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35875518
62SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34757112
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34306197
64CTCF_18555785_Chip-Seq_ESCs_Mouse1.33995700
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33755208
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33755208
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31676043
68IRF1_19129219_ChIP-ChIP_H3396_Human1.29288382
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28597949
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.26514079
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25167098
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24758300
73ER_23166858_ChIP-Seq_MCF-7_Human1.23608168
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23186930
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21921942
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21648952
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18821629
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.17563197
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15568912
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.15406864
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13980354
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13886672
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.13841232
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13425861
85TCF4_23295773_ChIP-Seq_U87_Human1.12609920
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12326354
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12132306
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12061543
89AR_25329375_ChIP-Seq_VCAP_Human1.11471300
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10664789
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09896822
92VDR_22108803_ChIP-Seq_LS180_Human1.09456286
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09125557
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.08332872
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07393926
96KDM2B_26808549_Chip-Seq_REH_Human1.07184499
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07040997
98STAT3_23295773_ChIP-Seq_U87_Human1.04442738
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.03617838
100JUN_21703547_ChIP-Seq_K562_Human1.02251957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.72608033
2MP0001188_hyperpigmentation3.70934446
3MP0000566_synostosis3.41312704
4MP0005645_abnormal_hypothalamus_physiol3.24049257
5MP0001986_abnormal_taste_sensitivity3.09020482
6MP0001835_abnormal_antigen_presentation2.67054060
7MP0002638_abnormal_pupillary_reflex2.61790790
8MP0002277_abnormal_respiratory_mucosa2.45666834
9MP0009697_abnormal_copulation2.43378505
10* MP0005646_abnormal_pituitary_gland2.42567067
11MP0002163_abnormal_gland_morphology2.28673716
12MP0010386_abnormal_urinary_bladder2.24973312
13MP0002876_abnormal_thyroid_physiology2.23018725
14MP0002148_abnormal_hypersensitivity_rea2.19526707
15MP0002132_abnormal_respiratory_system2.12759407
16MP0003787_abnormal_imprinting2.09366598
17MP0005171_absent_coat_pigmentation2.00458703
18MP0000015_abnormal_ear_pigmentation1.97823481
19MP0009785_altered_susceptibility_to1.95228560
20MP0000678_abnormal_parathyroid_gland1.92058909
21MP0001984_abnormal_olfaction1.90601701
22MP0005379_endocrine/exocrine_gland_phen1.73728937
23MP0003136_yellow_coat_color1.64580772
24MP0003183_abnormal_peptide_metabolism1.58983589
25MP0005671_abnormal_response_to1.58367572
26MP0000569_abnormal_digit_pigmentation1.58320688
27MP0002102_abnormal_ear_morphology1.52359626
28MP0000372_irregular_coat_pigmentation1.51724276
29MP0006276_abnormal_autonomic_nervous1.48152373
30MP0005075_abnormal_melanosome_morpholog1.44668003
31MP0001790_abnormal_immune_system1.42032218
32MP0005387_immune_system_phenotype1.42032218
33MP0005084_abnormal_gallbladder_morpholo1.39179882
34MP0002419_abnormal_innate_immunity1.38640358
35MP0003941_abnormal_skin_development1.36346965
36MP0000049_abnormal_middle_ear1.35755450
37MP0003122_maternal_imprinting1.34532251
38MP0008004_abnormal_stomach_pH1.29484844
39MP0005423_abnormal_somatic_nervous1.28489251
40MP0001529_abnormal_vocalization1.27242908
41MP0008058_abnormal_DNA_repair1.22133301
42MP0002938_white_spotting1.21229729
43MP0009764_decreased_sensitivity_to1.20948174
44MP0004742_abnormal_vestibular_system1.17969513
45MP0002452_abnormal_antigen_presenting1.15033965
46MP0005025_abnormal_response_to1.14792342
47MP0002735_abnormal_chemical_nociception1.13728823
48MP0003121_genomic_imprinting1.13128534
49MP0005000_abnormal_immune_tolerance1.12358217
50MP0002736_abnormal_nociception_after1.10691553
51* MP0000681_abnormal_thyroid_gland1.09754025
52MP0005310_abnormal_salivary_gland1.09221547
53MP0003436_decreased_susceptibility_to1.04790509
54MP0003943_abnormal_hepatobiliary_system1.03386931
55MP0004381_abnormal_hair_follicle1.02672850
56MP0001186_pigmentation_phenotype1.02519610
57MP0000026_abnormal_inner_ear1.02370254
58MP0005551_abnormal_eye_electrophysiolog1.00918524
59MP0008260_abnormal_autophagy0.99279701
60MP0005174_abnormal_tail_pigmentation0.99137965
61MP0001819_abnormal_immune_cell0.97971915
62MP0005503_abnormal_tendon_morphology0.97755921
63MP0001800_abnormal_humoral_immune0.97314762
64MP0002723_abnormal_immune_serum0.96498680
65MP0005253_abnormal_eye_physiology0.95986549
66MP0001502_abnormal_circadian_rhythm0.95661394
67MP0002420_abnormal_adaptive_immunity0.95303606
68MP0002095_abnormal_skin_pigmentation0.94710538
69MP0004147_increased_porphyrin_level0.94699127
70MP0003724_increased_susceptibility_to0.93925597
71MP0001486_abnormal_startle_reflex0.93191160
72MP0001764_abnormal_homeostasis0.89927533
73MP0003878_abnormal_ear_physiology0.89723866
74MP0005377_hearing/vestibular/ear_phenot0.89723866
75MP0002249_abnormal_larynx_morphology0.88274210
76MP0005248_abnormal_Harderian_gland0.88270933
77MP0005257_abnormal_intraocular_pressure0.88144897
78MP0001346_abnormal_lacrimal_gland0.86313290
79MP0002557_abnormal_social/conspecific_i0.83324165
80MP0003880_abnormal_central_pattern0.82924067
81* MP0001119_abnormal_female_reproductive0.81286875
82MP0002751_abnormal_autonomic_nervous0.80056518
83MP0003011_delayed_dark_adaptation0.79692790
84MP0008007_abnormal_cellular_replicative0.77094647
85MP0003938_abnormal_ear_development0.76194925
86MP0005451_abnormal_body_composition0.75717239
87MP0002098_abnormal_vibrissa_morphology0.75351446
88MP0009745_abnormal_behavioral_response0.74497320
89MP0002396_abnormal_hematopoietic_system0.73816387
90* MP0000631_abnormal_neuroendocrine_gland0.73682972
91MP0003763_abnormal_thymus_physiology0.72357640
92MP0002177_abnormal_outer_ear0.72083568
93MP0002572_abnormal_emotion/affect_behav0.71692403
94MP0002075_abnormal_coat/hair_pigmentati0.71553470
95MP0002127_abnormal_cardiovascular_syste0.70894162
96MP0001968_abnormal_touch/_nociception0.69576470
97MP0001270_distended_abdomen0.69207142
98MP0002998_abnormal_bone_remodeling0.68883317
99MP0001324_abnormal_eye_pigmentation0.68605605
100MP0001501_abnormal_sleep_pattern0.68343347

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.03123451
2Chromsome breakage (HP:0040012)4.35326632
3Abnormality of the renal collecting system (HP:0004742)3.57463918
4True hermaphroditism (HP:0010459)3.26711222
5Alveolar cell carcinoma (HP:0006519)3.08971002
6Duplicated collecting system (HP:0000081)3.08857642
7Optic neuritis (HP:0100653)3.05414972
8Retrobulbar optic neuritis (HP:0100654)3.05414972
9Congenital stationary night blindness (HP:0007642)2.98561395
10Osteomalacia (HP:0002749)2.95656516
11Thyroid-stimulating hormone excess (HP:0002925)2.88985635
12Abnormal hair whorl (HP:0010721)2.87021871
13Hypothermia (HP:0002045)2.83447735
14Ectopic kidney (HP:0000086)2.81356316
15Type I transferrin isoform profile (HP:0003642)2.79384215
16Febrile seizures (HP:0002373)2.77836733
17Chronic hepatic failure (HP:0100626)2.64920076
18Pancreatic fibrosis (HP:0100732)2.64398682
19Protruding tongue (HP:0010808)2.61639603
20Reduced antithrombin III activity (HP:0001976)2.60817418
21Absent eyebrow (HP:0002223)2.54072166
22Recurrent abscess formation (HP:0002722)2.50819633
23Clubbing of toes (HP:0100760)2.47854190
24Hypoplasia of the fovea (HP:0007750)2.46986517
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.46986517
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.45184224
27Decreased central vision (HP:0007663)2.42301920
28Congenital sensorineural hearing impairment (HP:0008527)2.42087402
29Neoplasm of the tracheobronchial system (HP:0100552)2.39414435
30Orchitis (HP:0100796)2.35226010
31Nephrogenic diabetes insipidus (HP:0009806)2.34509576
32Pancreatic cysts (HP:0001737)2.30706035
33Abnormality of the preputium (HP:0100587)2.29497782
34Increased IgM level (HP:0003496)2.28812030
35Medial flaring of the eyebrow (HP:0010747)2.25010656
36Type 2 muscle fiber atrophy (HP:0003554)2.24449723
37Abnormality of incisor morphology (HP:0011063)2.24128192
38Prostate neoplasm (HP:0100787)2.23854746
39Meckel diverticulum (HP:0002245)2.20637504
40Abnormality of the ileum (HP:0001549)2.19647669
41Decreased circulating renin level (HP:0003351)2.17496175
42Mediastinal lymphadenopathy (HP:0100721)2.17464717
43Renal cortical cysts (HP:0000803)2.17077332
44Myositis (HP:0100614)2.08997945
45Fair hair (HP:0002286)2.04551384
46Recurrent bacterial skin infections (HP:0005406)2.03130518
47Abnormality of chromosome stability (HP:0003220)2.00572370
48Preaxial hand polydactyly (HP:0001177)2.00176881
49Pulmonary infiltrates (HP:0002113)1.96870487
50Abnormality of DNA repair (HP:0003254)1.95113507
51White forelock (HP:0002211)1.93958920
52Dry hair (HP:0011359)1.92669812
53Oligohydramnios (HP:0001562)1.91104729
54Congenital primary aphakia (HP:0007707)1.90721426
55Abnormality of the prostate (HP:0008775)1.90539107
56Abnormality of the renal cortex (HP:0011035)1.88744293
57Bilateral sensorineural hearing impairment (HP:0008619)1.87777308
58Patchy hypopigmentation of hair (HP:0011365)1.87133496
59Abnormal biliary tract physiology (HP:0012439)1.86687903
60Bile duct proliferation (HP:0001408)1.86687903
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.84977654
62Absent/shortened dynein arms (HP:0200106)1.84977654
63Attenuation of retinal blood vessels (HP:0007843)1.84916632
64Duplication of thumb phalanx (HP:0009942)1.84880457
65Conjugated hyperbilirubinemia (HP:0002908)1.82197920
66Abnormality of the fovea (HP:0000493)1.80487486
67Congenital hepatic fibrosis (HP:0002612)1.80166531
68Postaxial foot polydactyly (HP:0001830)1.80140683
69Eczematoid dermatitis (HP:0000976)1.78097594
70Gait imbalance (HP:0002141)1.77617433
71Cheilitis (HP:0100825)1.75665482
72Tubulointerstitial nephritis (HP:0001970)1.74401138
73Optic nerve coloboma (HP:0000588)1.74041468
74Keratoconjunctivitis sicca (HP:0001097)1.73763995
75Muscle fiber atrophy (HP:0100295)1.73570781
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73551409
77Tetany (HP:0001281)1.72940311
78Astigmatism (HP:0000483)1.72891088
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72394853
80Abnormal protein N-linked glycosylation (HP:0012347)1.72394853
81Abnormal protein glycosylation (HP:0012346)1.72394853
82Abnormal glycosylation (HP:0012345)1.72394853
83Renal dysplasia (HP:0000110)1.71657215
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.71508319
85Anomalous pulmonary venous return (HP:0010772)1.71037401
86Glomerulopathy (HP:0100820)1.70751242
87Abnormality of the nasal septum (HP:0000419)1.70515258
88Abnormal ciliary motility (HP:0012262)1.69418436
89Hypoplastic heart (HP:0001961)1.69327538
90Generalized hypopigmentation of hair (HP:0011358)1.68677655
91Abnormality of the renal medulla (HP:0100957)1.68314155
92Recurrent pneumonia (HP:0006532)1.68227598
93Conical tooth (HP:0000698)1.67066941
94Hypergonadotropic hypogonadism (HP:0000815)1.66957103
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.65387752
96Hyperphosphatemia (HP:0002905)1.64789894
97Recurrent gram-negative bacterial infections (HP:0005420)1.64359970
98Keratoconjunctivitis (HP:0001096)1.64159972
99Pulmonary artery stenosis (HP:0004415)1.61901249
100Aplasia of the musculature (HP:0100854)1.61387703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.88571824
2PRPF4B3.59154425
3CASK3.31718524
4MAP3K143.02707786
5TNIK2.97994196
6ZAK2.78927411
7IRAK32.70965372
8IRAK42.53453266
9TXK2.36884656
10INSRR2.03737824
11BMPR1B2.00993949
12SGK21.93246438
13ADRBK21.81382629
14STK38L1.81207666
15TAOK21.79324410
16AKT31.78702300
17STK241.58981994
18MAP2K71.57363604
19YES11.55471519
20NEK61.49283769
21ERBB31.48328737
22TEC1.48037658
23BMPR21.46590829
24CDK81.42698141
25EIF2AK21.42440998
26TIE11.31320229
27CCNB11.30072865
28BCR1.27953160
29MAPK131.25904474
30WNK31.21997115
31CLK11.19133008
32STK161.17996307
33SGK2231.17838615
34SGK4941.17838615
35NUAK11.11857854
36SRPK11.06893728
37CDK31.04665477
38MAP3K121.04561842
39SGK31.00441342
40IKBKB0.99221055
41JAK30.94720199
42NTRK30.92811163
43GRK10.91009601
44SIK20.87411550
45PBK0.86690535
46TRPM70.85497963
47CHUK0.83549811
48MUSK0.81068162
49NLK0.80594945
50VRK10.78479860
51ACVR1B0.76507122
52NEK90.75919426
53IKBKE0.75896266
54EPHB20.74394558
55OBSCN0.72435050
56BLK0.68617963
57MAPK70.67625732
58GRK70.67091594
59TAOK30.66000971
60BRAF0.65573278
61TSSK60.65304692
62PIM20.64937973
63PRKCE0.64632146
64MARK30.63562887
65EPHA30.63314802
66MKNK20.62934105
67PINK10.62405322
68MYLK0.60820917
69EIF2AK30.60800999
70EPHA40.59857421
71PLK20.58369205
72PASK0.57383904
73BTK0.57292896
74ATR0.55446354
75MKNK10.55109321
76IRAK10.54350186
77RPS6KB10.53456806
78SYK0.53037476
79LYN0.52936394
80IRAK20.52063436
81KIT0.49588260
82MAP2K60.48524951
83RPS6KA60.46843041
84TYK20.46533693
85RPS6KA20.45009384
86SIK10.44645369
87BRD40.42337199
88DYRK20.42106749
89TBK10.42029753
90RPS6KL10.40310658
91RPS6KC10.40310658
92PIK3CG0.38062258
93TNK20.37021928
94PRKCD0.33853393
95SGK10.32465533
96STK40.31453582
97PRKCG0.31113267
98DYRK1A0.29696724
99ADRBK10.28552751
100JAK10.28518100

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.91076363
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72862455
3Graft-versus-host disease_Homo sapiens_hsa053322.44556257
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.38090039
5Autoimmune thyroid disease_Homo sapiens_hsa053202.32502091
6Type I diabetes mellitus_Homo sapiens_hsa049402.29321224
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14237394
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.11374229
9Fanconi anemia pathway_Homo sapiens_hsa034602.05639271
10Homologous recombination_Homo sapiens_hsa034402.02938525
11Rheumatoid arthritis_Homo sapiens_hsa053232.02809050
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02563985
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.01622648
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95438558
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.94466449
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92764670
17Base excision repair_Homo sapiens_hsa034101.90671787
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80760881
19Phototransduction_Homo sapiens_hsa047441.79708811
20Measles_Homo sapiens_hsa051621.74576145
21Nicotine addiction_Homo sapiens_hsa050331.68439618
22Asthma_Homo sapiens_hsa053101.68121017
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59559164
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56985515
25Leishmaniasis_Homo sapiens_hsa051401.42431708
26Primary immunodeficiency_Homo sapiens_hsa053401.37723710
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32522191
28Hematopoietic cell lineage_Homo sapiens_hsa046401.28954839
29Herpes simplex infection_Homo sapiens_hsa051681.28140632
30Influenza A_Homo sapiens_hsa051641.26421363
31Protein export_Homo sapiens_hsa030601.25783448
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24992649
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21225348
34Taste transduction_Homo sapiens_hsa047421.20816600
35Phagosome_Homo sapiens_hsa041451.17955895
36Basal transcription factors_Homo sapiens_hsa030221.16674683
37One carbon pool by folate_Homo sapiens_hsa006701.16022177
38Legionellosis_Homo sapiens_hsa051341.11843748
39DNA replication_Homo sapiens_hsa030301.09244567
40African trypanosomiasis_Homo sapiens_hsa051431.08517204
41Arachidonic acid metabolism_Homo sapiens_hsa005901.08169707
42Sphingolipid metabolism_Homo sapiens_hsa006001.00294047
43Morphine addiction_Homo sapiens_hsa050320.98123967
44Olfactory transduction_Homo sapiens_hsa047400.94149909
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94093651
46Pertussis_Homo sapiens_hsa051330.91908286
47Malaria_Homo sapiens_hsa051440.89972908
48Collecting duct acid secretion_Homo sapiens_hsa049660.88098176
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.87335272
50Mismatch repair_Homo sapiens_hsa034300.86112034
51TNF signaling pathway_Homo sapiens_hsa046680.85899889
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.85159489
53Tuberculosis_Homo sapiens_hsa051520.80932547
54Serotonergic synapse_Homo sapiens_hsa047260.80833164
55Purine metabolism_Homo sapiens_hsa002300.80617728
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79203371
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76525963
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74516153
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74165421
60Nucleotide excision repair_Homo sapiens_hsa034200.73431418
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73243817
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.72032866
63RNA degradation_Homo sapiens_hsa030180.71089751
64Pyrimidine metabolism_Homo sapiens_hsa002400.69007293
65N-Glycan biosynthesis_Homo sapiens_hsa005100.67377097
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65468336
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65285559
68Other glycan degradation_Homo sapiens_hsa005110.65046147
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63928867
70Calcium signaling pathway_Homo sapiens_hsa040200.63400652
71Vitamin digestion and absorption_Homo sapiens_hsa049770.62521658
72Non-homologous end-joining_Homo sapiens_hsa034500.56863416
73Osteoclast differentiation_Homo sapiens_hsa043800.52386472
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.51515189
75Circadian rhythm_Homo sapiens_hsa047100.50507474
76Chemokine signaling pathway_Homo sapiens_hsa040620.50371345
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50149191
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49298386
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44828586
80Retinol metabolism_Homo sapiens_hsa008300.44712120
81Hepatitis C_Homo sapiens_hsa051600.42441652
82Hepatitis B_Homo sapiens_hsa051610.42272596
83Staphylococcus aureus infection_Homo sapiens_hsa051500.42090960
84Regulation of autophagy_Homo sapiens_hsa041400.38926811
85Apoptosis_Homo sapiens_hsa042100.38758068
86Synaptic vesicle cycle_Homo sapiens_hsa047210.38443508
87Mineral absorption_Homo sapiens_hsa049780.36674101
88Basal cell carcinoma_Homo sapiens_hsa052170.35438257
89Circadian entrainment_Homo sapiens_hsa047130.35197993
90Vibrio cholerae infection_Homo sapiens_hsa051100.34531682
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34208383
92Toxoplasmosis_Homo sapiens_hsa051450.33379514
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32295160
94HTLV-I infection_Homo sapiens_hsa051660.30704393
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30465097
96Melanoma_Homo sapiens_hsa052180.30115064
97Shigellosis_Homo sapiens_hsa051310.29764597
98Ovarian steroidogenesis_Homo sapiens_hsa049130.29374287
99Salmonella infection_Homo sapiens_hsa051320.29223121
100Axon guidance_Homo sapiens_hsa043600.28042523

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