PRMT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle cell fate commitment (GO:0042693)4.90014721
2rRNA transcription (GO:0009303)4.82488277
3DNA strand elongation involved in DNA replication (GO:0006271)4.82452465
4tooth mineralization (GO:0034505)4.80426097
5DNA replication initiation (GO:0006270)4.74717999
6oxidative phosphorylation (GO:0006119)4.69621707
7nucleobase biosynthetic process (GO:0046112)4.69187842
8DNA unwinding involved in DNA replication (GO:0006268)4.59272852
9DNA strand elongation (GO:0022616)4.59098619
10maturation of SSU-rRNA (GO:0030490)4.53121361
11homocysteine metabolic process (GO:0050667)4.49188834
12ribosomal small subunit assembly (GO:0000028)4.42933459
13formation of translation preinitiation complex (GO:0001731)4.41029811
14L-serine metabolic process (GO:0006563)4.38659777
15telomere maintenance via semi-conservative replication (GO:0032201)4.33248323
16purine nucleobase biosynthetic process (GO:0009113)4.32182048
17IMP biosynthetic process (GO:0006188)4.30056342
18amyloid precursor protein catabolic process (GO:0042987)4.25342325
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.21629165
20protein localization to kinetochore (GO:0034501)4.04517848
21DNA replication checkpoint (GO:0000076)3.99454932
22muscle organ morphogenesis (GO:0048644)3.99056568
23sulfur amino acid catabolic process (GO:0000098)3.96706238
24DNA replication-dependent nucleosome assembly (GO:0006335)3.91006150
25DNA replication-dependent nucleosome organization (GO:0034723)3.91006150
26mitotic metaphase plate congression (GO:0007080)3.90348416
27ribosome biogenesis (GO:0042254)3.87750404
28ribosomal large subunit biogenesis (GO:0042273)3.85157849
29histone H4-K12 acetylation (GO:0043983)3.82403460
30IMP metabolic process (GO:0046040)3.79373227
31pyrimidine nucleotide catabolic process (GO:0006244)3.78993963
32spliceosomal tri-snRNP complex assembly (GO:0000244)3.78311421
33DNA deamination (GO:0045006)3.77860444
34ribonucleoprotein complex biogenesis (GO:0022613)3.76264809
35mitotic nuclear envelope disassembly (GO:0007077)3.74783130
36telomere maintenance via recombination (GO:0000722)3.73156475
37nuclear pore organization (GO:0006999)3.71290597
38cullin deneddylation (GO:0010388)3.70000093
39establishment of integrated proviral latency (GO:0075713)3.69933592
40viral transcription (GO:0019083)3.68905294
41chromatin remodeling at centromere (GO:0031055)3.68512283
42translational termination (GO:0006415)3.65262365
43CENP-A containing nucleosome assembly (GO:0034080)3.61107783
44NADH dehydrogenase complex assembly (GO:0010257)3.60128000
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60128000
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.60128000
47ribosomal small subunit biogenesis (GO:0042274)3.59736971
48histone H4-K5 acetylation (GO:0043981)3.58016781
49histone H4-K8 acetylation (GO:0043982)3.58016781
50metallo-sulfur cluster assembly (GO:0031163)3.57458215
51iron-sulfur cluster assembly (GO:0016226)3.57458215
52folic acid-containing compound biosynthetic process (GO:0009396)3.55716572
53pentose metabolic process (GO:0019321)3.55642755
54* spliceosomal snRNP assembly (GO:0000387)3.54717318
55mitotic recombination (GO:0006312)3.53266569
56protein localization to chromosome, centromeric region (GO:0071459)3.49749998
57metaphase plate congression (GO:0051310)3.48714656
58telomere maintenance via telomere lengthening (GO:0010833)3.48245326
59translational elongation (GO:0006414)3.48009578
60membrane disassembly (GO:0030397)3.47626258
61nuclear envelope disassembly (GO:0051081)3.47626258
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.45652036
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45280425
64proteasome assembly (GO:0043248)3.45168742
65rRNA processing (GO:0006364)3.43551009
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43243808
67protein deneddylation (GO:0000338)3.43235680
68translational initiation (GO:0006413)3.43186351
69mitochondrial RNA metabolic process (GO:0000959)3.42450017
70regulation of translational fidelity (GO:0006450)3.38772318
71nuclear pore complex assembly (GO:0051292)3.35767135
72spliceosomal complex assembly (GO:0000245)3.35333568
73mitotic sister chromatid segregation (GO:0000070)3.35198966
74pseudouridine synthesis (GO:0001522)3.34577592
75rRNA metabolic process (GO:0016072)3.33068834
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32646542
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32290493
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.32290493
79folic acid metabolic process (GO:0046655)3.31580214
80* peptidyl-arginine omega-N-methylation (GO:0035247)3.30789289
81peptidyl-histidine modification (GO:0018202)3.30484628
82ribosome assembly (GO:0042255)3.30384724
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29709091
84viral mRNA export from host cell nucleus (GO:0046784)3.28738763
85pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27522469
86DNA replication-independent nucleosome assembly (GO:0006336)3.27155828
87DNA replication-independent nucleosome organization (GO:0034724)3.27155828
88protein complex biogenesis (GO:0070271)3.23694973
89apoptotic process involved in morphogenesis (GO:0060561)3.22181170
90kinetochore organization (GO:0051383)3.20623260
91mitotic G1 DNA damage checkpoint (GO:0031571)3.20482879
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20481648
93histone exchange (GO:0043486)3.19860165
94tRNA aminoacylation for protein translation (GO:0006418)3.19025321
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18635509
96maturation of 5.8S rRNA (GO:0000460)3.18346509
97negative regulation of ligase activity (GO:0051352)3.17368714
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17368714
99guanosine-containing compound biosynthetic process (GO:1901070)3.17280684
100amino acid activation (GO:0043038)3.14630967
101tRNA aminoacylation (GO:0043039)3.14630967
102positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.14395524
103* histone arginine methylation (GO:0034969)3.13994848
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13919500
105establishment of chromosome localization (GO:0051303)3.12958675
106mitochondrial respiratory chain complex assembly (GO:0033108)3.12265413
107negative regulation of telomerase activity (GO:0051974)3.11940888
108histone H2A acetylation (GO:0043968)3.11478431
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11021185
110DNA duplex unwinding (GO:0032508)3.10534144
111galactose catabolic process (GO:0019388)3.09783522
112GDP-mannose metabolic process (GO:0019673)3.08956395
113cellular protein complex disassembly (GO:0043624)3.08736314
114DNA geometric change (GO:0032392)3.08344091
115ncRNA 3-end processing (GO:0043628)3.07832466
116outflow tract septum morphogenesis (GO:0003148)3.06742964
117cotranslational protein targeting to membrane (GO:0006613)3.06250362
118pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.06191091
119transcription-coupled nucleotide-excision repair (GO:0006283)3.04442920
120cellular component biogenesis (GO:0044085)3.04094036
121UTP biosynthetic process (GO:0006228)3.03967202
122negative regulation of chromosome segregation (GO:0051985)3.03636035
123kinetochore assembly (GO:0051382)3.03409672
124cell cycle G1/S phase transition (GO:0044843)3.03033284
125G1/S transition of mitotic cell cycle (GO:0000082)3.03033284
126protein targeting to ER (GO:0045047)3.02835445
127negative regulation of mitotic sister chromatid separation (GO:2000816)3.01886079
128negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01886079
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01886079
130negative regulation of sister chromatid segregation (GO:0033046)3.01886079
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01780078
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01780078
133attachment of spindle microtubules to kinetochore (GO:0008608)3.01568687
134translation (GO:0006412)3.00370532
135snRNA metabolic process (GO:0016073)2.98584738
136postreplication repair (GO:0006301)2.98112787
137mitochondrial DNA metabolic process (GO:0032042)2.98105960
138rRNA modification (GO:0000154)2.96776290
139cranial nerve morphogenesis (GO:0021602)2.94983160
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94478789
141histone H4-K16 acetylation (GO:0043984)2.94471421
142protein complex disassembly (GO:0043241)2.94265006
143CTP metabolic process (GO:0046036)2.93930134
144CTP biosynthetic process (GO:0006241)2.93930134
145mitotic spindle assembly checkpoint (GO:0007094)2.93465700
146regulation of translational termination (GO:0006449)2.93432709
147spindle assembly checkpoint (GO:0071173)2.92960857
148polyamine biosynthetic process (GO:0006596)2.92858960
149spindle checkpoint (GO:0031577)2.92759664
150pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92647068
151replicative senescence (GO:0090399)2.91861128
152DNA strand renaturation (GO:0000733)2.91635870
153chaperone-mediated protein transport (GO:0072321)2.87092499
154tRNA modification (GO:0006400)2.85715678
155protein targeting to mitochondrion (GO:0006626)2.83502448
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82079870
157nucleotide salvage (GO:0043173)2.81871258
158atrial septum morphogenesis (GO:0060413)2.81569772
159proline biosynthetic process (GO:0006561)2.81474283
160midgut development (GO:0007494)2.80570871
161regulation of cardioblast proliferation (GO:0003264)2.80515061
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.80515061
163serine family amino acid biosynthetic process (GO:0009070)2.78030181
164mitotic G1/S transition checkpoint (GO:0044819)2.77755312
165chromatin assembly (GO:0031497)2.76963534
166UTP metabolic process (GO:0046051)2.76699994
167mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.76591422
168rRNA methylation (GO:0031167)2.74648958
169regulation of mitochondrial translation (GO:0070129)2.74530743
170regulation of chromatin binding (GO:0035561)2.74405604
171viral life cycle (GO:0019058)2.72407943
172base-excision repair, AP site formation (GO:0006285)2.72161629
173embryonic viscerocranium morphogenesis (GO:0048703)2.72083877
174mitochondrial fusion (GO:0008053)2.71899300
175pharyngeal system development (GO:0060037)2.71041989
176establishment of protein localization to mitochondrion (GO:0072655)2.70633016
177ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68926106
178base-excision repair (GO:0006284)2.68813698
179snRNA processing (GO:0016180)2.67241290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12217659
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.70104772
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98831863
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56496257
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51929054
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37850184
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.34402336
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.26725120
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24458114
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15846629
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.11461139
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.09159553
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.03410281
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.95075738
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94098798
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84250599
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83289884
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77937910
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58170138
20* XRN2_22483619_ChIP-Seq_HELA_Human2.48349944
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48113668
22VDR_21846776_ChIP-Seq_THP-1_Human2.47052380
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33721109
24VDR_23849224_ChIP-Seq_CD4+_Human2.25550700
25LXR_22292898_ChIP-Seq_THP-1_Human2.20966386
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15849184
27DCP1A_22483619_ChIP-Seq_HELA_Human2.14469884
28FOXP3_21729870_ChIP-Seq_TREG_Human2.12812022
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10902401
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05057515
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.04862423
32GABP_19822575_ChIP-Seq_HepG2_Human2.01594859
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01294242
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00181998
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.99809323
36TTF2_22483619_ChIP-Seq_HELA_Human1.98009590
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92812013
38ZNF263_19887448_ChIP-Seq_K562_Human1.90911507
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87025566
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86427419
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.84214540
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82855237
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79078944
44P68_20966046_ChIP-Seq_HELA_Human1.78911988
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78127660
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76868639
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75473364
48AR_21909140_ChIP-Seq_LNCAP_Human1.73373621
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72751648
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69691008
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68003280
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66402964
53CIITA_25753668_ChIP-Seq_RAJI_Human1.64666876
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.62070974
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60508062
56ELK1_19687146_ChIP-ChIP_HELA_Human1.58052211
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53627873
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51153987
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50383886
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49031402
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46622972
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43722272
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.43307570
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43242840
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42877132
66FOXP1_21924763_ChIP-Seq_HESCs_Human1.41797869
67* YY1_22570637_ChIP-Seq_MALME-3M_Human1.40791293
68* ELF1_20517297_ChIP-Seq_JURKAT_Human1.40318312
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40196785
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39337039
71KDM5A_27292631_Chip-Seq_BREAST_Human1.38693443
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.37489897
73CTCF_26484167_Chip-Seq_Bcells_Mouse1.37366168
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35764381
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.35241245
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34046890
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33759587
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32444611
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32342979
80RACK7_27058665_Chip-Seq_MCF-7_Human1.31884209
81MAF_26560356_Chip-Seq_TH2_Human1.31775828
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30153348
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29316599
84SMC4_20622854_ChIP-Seq_HELA_Human1.27303931
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26983305
86* BCL6_27268052_Chip-Seq_Bcells_Human1.26288173
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23936513
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22936460
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.22719350
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22386423
91MYC_22102868_ChIP-Seq_BL_Human1.18358271
92* KDM2B_26808549_Chip-Seq_DND41_Human1.18342379
93BCOR_27268052_Chip-Seq_Bcells_Human1.17957987
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17844023
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17636494
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16833431
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15706183
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15487664
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15407972
100CTCF_27219007_Chip-Seq_Bcells_Human1.13730335
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13326266
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11143837
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11135827
104CREB1_26743006_Chip-Seq_LNCaP_Human1.11082192
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10796200
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.10657609
107* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10387359
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10349361
109CTCF_21964334_Chip-Seq_Bcells_Human1.09656653
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09030128
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08961952
112MYC_18940864_ChIP-ChIP_HL60_Human1.08350695
113* PHF8_20622854_ChIP-Seq_HELA_Human1.06951240
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06846280
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06495839
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06492929
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03114560
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02961134
119TFEB_21752829_ChIP-Seq_HELA_Human1.02842368
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02363685
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01319110
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.99551502
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98800684
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96067235
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92457358
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.92382548
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91645990
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90477479
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87925077
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87737830
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86776929
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.85964105
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81049630
134* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80949053
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78047290
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.77912730
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77889616
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77576740
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.77394655
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75886313
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75480178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39509824
2MP0010094_abnormal_chromosome_stability5.12826733
3MP0004957_abnormal_blastocyst_morpholog4.77651165
4MP0003111_abnormal_nucleus_morphology4.62811184
5MP0003077_abnormal_cell_cycle4.08280609
6MP0008058_abnormal_DNA_repair3.87096263
7MP0008057_abnormal_DNA_replication3.76951394
8MP0002234_abnormal_pharynx_morphology3.53284635
9MP0008877_abnormal_DNA_methylation3.32658478
10MP0003123_paternal_imprinting3.17821123
11MP0008932_abnormal_embryonic_tissue3.08802016
12MP0000678_abnormal_parathyroid_gland2.98929837
13MP0002249_abnormal_larynx_morphology2.97124246
14MP0008007_abnormal_cellular_replicative2.84544460
15MP0005670_abnormal_white_adipose2.54193916
16MP0001730_embryonic_growth_arrest2.50979117
17MP0000350_abnormal_cell_proliferation2.30737362
18MP0000003_abnormal_adipose_tissue2.29491124
19MP0003786_premature_aging2.26517649
20MP0000013_abnormal_adipose_tissue2.19835670
21MP0002822_catalepsy2.07532229
22MP0004130_abnormal_muscle_cell2.03566132
23MP0002396_abnormal_hematopoietic_system1.92654767
24MP0001697_abnormal_embryo_size1.87833846
25MP0004185_abnormal_adipocyte_glucose1.84310302
26MP0001661_extended_life_span1.83003045
27MP0003806_abnormal_nucleotide_metabolis1.81885667
28MP0000049_abnormal_middle_ear1.79513118
29MP0008260_abnormal_autophagy1.79013076
30MP0001672_abnormal_embryogenesis/_devel1.74588383
31MP0005380_embryogenesis_phenotype1.74588383
32MP0002210_abnormal_sex_determination1.72341228
33MP0002080_prenatal_lethality1.72200358
34MP0000733_abnormal_muscle_development1.70565460
35MP0010352_gastrointestinal_tract_polyps1.69244529
36MP0002163_abnormal_gland_morphology1.67620766
37MP0003121_genomic_imprinting1.67433795
38MP0004133_heterotaxia1.65890416
39MP0003718_maternal_effect1.64301144
40MP0005451_abnormal_body_composition1.61945245
41MP0003890_abnormal_embryonic-extraembry1.60979909
42MP0001929_abnormal_gametogenesis1.59815369
43MP0002085_abnormal_embryonic_tissue1.58213630
44MP0003984_embryonic_growth_retardation1.57054078
45MP0010307_abnormal_tumor_latency1.55221839
46MP0000313_abnormal_cell_death1.52035669
47MP0005083_abnormal_biliary_tract1.51827137
48MP0002088_abnormal_embryonic_growth/wei1.51346044
49MP0001145_abnormal_male_reproductive1.51069346
50MP0002084_abnormal_developmental_patter1.49395039
51MP0006035_abnormal_mitochondrial_morpho1.46283679
52MP0001348_abnormal_lacrimal_gland1.46280612
53MP0002160_abnormal_reproductive_system1.45418383
54MP0000490_abnormal_crypts_of1.41299266
55MP0002653_abnormal_ependyma_morphology1.41220210
56MP0006036_abnormal_mitochondrial_physio1.37211747
57MP0003315_abnormal_perineum_morphology1.34751085
58MP0004197_abnormal_fetal_growth/weight/1.33622018
59MP0000759_abnormal_skeletal_muscle1.31368644
60MP0000358_abnormal_cell_content/1.30346384
61MP0003183_abnormal_peptide_metabolism1.28161765
62MP0006292_abnormal_olfactory_placode1.27805845
63MP0002019_abnormal_tumor_incidence1.26678700
64MP0001270_distended_abdomen1.25984849
65MP0002086_abnormal_extraembryonic_tissu1.25621717
66MP0000653_abnormal_sex_gland1.25582576
67MP0003119_abnormal_digestive_system1.24038518
68MP0000762_abnormal_tongue_morphology1.23785902
69MP0003698_abnormal_male_reproductive1.22754001
70MP0003221_abnormal_cardiomyocyte_apopto1.21934957
71MP0001346_abnormal_lacrimal_gland1.20925890
72MP0005410_abnormal_fertilization1.16720247
73MP0003567_abnormal_fetal_cardiomyocyte1.16329932
74MP0000681_abnormal_thyroid_gland1.14233810
75MP0005375_adipose_tissue_phenotype1.12932942
76MP0004859_abnormal_synaptic_plasticity1.12613311
77MP0003705_abnormal_hypodermis_morpholog1.12320096
78MP0002932_abnormal_joint_morphology1.11875809
79MP0005220_abnormal_exocrine_pancreas1.04978821
80MP0004808_abnormal_hematopoietic_stem1.04037005
81MP0005646_abnormal_pituitary_gland1.02451367
82MP0001529_abnormal_vocalization1.02327954
83MP0005171_absent_coat_pigmentation1.02062518
84MP0009384_cardiac_valve_regurgitation1.01934038
85MP0009379_abnormal_foot_pigmentation1.01882408
86MP0000372_irregular_coat_pigmentation0.99318894
87MP0004233_abnormal_muscle_weight0.97642211
88MP0006276_abnormal_autonomic_nervous0.97298911
89MP0001764_abnormal_homeostasis0.97071251
90MP0010030_abnormal_orbit_morphology0.96987660
91MP0001293_anophthalmia0.95659594
92MP0000955_abnormal_spinal_cord0.95336061
93MP0003646_muscle_fatigue0.93819059
94MP0003137_abnormal_impulse_conducting0.91349186
95MP0005389_reproductive_system_phenotype0.90983532
96MP0002269_muscular_atrophy0.90708610
97MP0005266_abnormal_metabolism0.88486309
98MP0004858_abnormal_nervous_system0.88171695
99MP0000703_abnormal_thymus_morphology0.87742584
100MP0004381_abnormal_hair_follicle0.87451880
101MP0002161_abnormal_fertility/fecundity0.86811424
102MP0005384_cellular_phenotype0.85389392
103MP0005666_abnormal_adipose_tissue0.83228368
104MP0004145_abnormal_muscle_electrophysio0.82540142
105MP0000537_abnormal_urethra_morphology0.82297669
106MP0002106_abnormal_muscle_physiology0.80215021
107MP0002938_white_spotting0.79493812
108MP0009333_abnormal_splenocyte_physiolog0.79287880
109MP0004084_abnormal_cardiac_muscle0.77719804
110MP0009250_abnormal_appendicular_skeleto0.77273896
111MP0005360_urolithiasis0.77093585
112MP0005423_abnormal_somatic_nervous0.77021171
113MP0010630_abnormal_cardiac_muscle0.75534537
114MP0001873_stomach_inflammation0.75454514
115MP0002751_abnormal_autonomic_nervous0.73873454
116MP0009672_abnormal_birth_weight0.73725554
117MP0002970_abnormal_white_adipose0.73618213
118MP0002736_abnormal_nociception_after0.73058546
119MP0000749_muscle_degeneration0.72569135
120MP0003880_abnormal_central_pattern0.71047396
121MP0002111_abnormal_tail_morphology0.70649721
122MP0003861_abnormal_nervous_system0.70555741
123MP0002132_abnormal_respiratory_system0.70376232
124MP0005330_cardiomyopathy0.70160739
125MP0002089_abnormal_postnatal_growth/wei0.69973136
126MP0000371_diluted_coat_color0.69569759
127MP0001119_abnormal_female_reproductive0.68931922
128MP0004087_abnormal_muscle_fiber0.68829075
129MP0003787_abnormal_imprinting0.68348525
130MP0003122_maternal_imprinting0.68342623
131MP0009697_abnormal_copulation0.68078641
132MP0002075_abnormal_coat/hair_pigmentati0.67769315
133MP0008961_abnormal_basal_metabolism0.67263900
134MP0003186_abnormal_redox_activity0.67060434
135MP0005369_muscle_phenotype0.67021705
136MP0005623_abnormal_meninges_morphology0.66649586
137MP0003937_abnormal_limbs/digits/tail_de0.66562241
138MP0002722_abnormal_immune_system0.64807883
139MP0005621_abnormal_cell_physiology0.64005614
140MP0002127_abnormal_cardiovascular_syste0.61600408
141MP0008789_abnormal_olfactory_epithelium0.61293980
142MP0001919_abnormal_reproductive_system0.60986831
143MP0000689_abnormal_spleen_morphology0.60332913
144MP0000751_myopathy0.58546057
145MP0002398_abnormal_bone_marrow0.57830398
146MP0003763_abnormal_thymus_physiology0.57681306
147MP0008995_early_reproductive_senescence0.57232243
148MP0009053_abnormal_anal_canal0.55511143
149MP0001286_abnormal_eye_development0.54607217
150MP0005499_abnormal_olfactory_system0.54294682
151MP0005394_taste/olfaction_phenotype0.54294682
152MP0001545_abnormal_hematopoietic_system0.53856468
153MP0005397_hematopoietic_system_phenotyp0.53856468
154MP0005075_abnormal_melanosome_morpholog0.52499684
155MP0000750_abnormal_muscle_regeneration0.52291982
156MP0002102_abnormal_ear_morphology0.52252152
157MP0005076_abnormal_cell_differentiation0.50065652
158MP0001727_abnormal_embryo_implantation0.49729917
159MP0008770_decreased_survivor_rate0.47885498
160MP0004147_increased_porphyrin_level0.47578096

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)5.87529524
2Congenital malformation of the right heart (HP:0011723)5.87529524
3Birth length less than 3rd percentile (HP:0003561)4.91352283
4Truncus arteriosus (HP:0001660)4.71310261
5Reticulocytopenia (HP:0001896)4.19702735
6Abnormality of cells of the erythroid lineage (HP:0012130)4.14812192
7Abnormality of the aortic arch (HP:0012303)4.07911339
8Abnormal number of erythroid precursors (HP:0012131)3.95151402
9Colon cancer (HP:0003003)3.81961090
10Breast hypoplasia (HP:0003187)3.73909693
11Periauricular skin pits (HP:0100277)3.67675767
12Preauricular pit (HP:0004467)3.67675767
13Oral leukoplakia (HP:0002745)3.50786930
14Cerebral hypomyelination (HP:0006808)3.48750249
15Medulloblastoma (HP:0002885)3.41672164
16Aplastic anemia (HP:0001915)3.39755109
17Degeneration of anterior horn cells (HP:0002398)3.36434028
18Abnormality of the anterior horn cell (HP:0006802)3.36434028
19Selective tooth agenesis (HP:0001592)3.33226547
20Hypoplastic left heart (HP:0004383)3.21396457
21Transposition of the great arteries (HP:0001669)3.20624949
22Abnormal connection of the cardiac segments (HP:0011545)3.20624949
23Abnormal ventriculo-arterial connection (HP:0011563)3.20624949
24Increased muscle lipid content (HP:0009058)3.19748370
25Ependymoma (HP:0002888)3.16374964
26Patellar aplasia (HP:0006443)3.15388197
27Chromsome breakage (HP:0040012)3.12171516
28Abnormality of the labia minora (HP:0012880)3.10670796
29Hypoparathyroidism (HP:0000829)3.08070217
30Abnormality of the preputium (HP:0100587)3.07992924
31Hepatocellular necrosis (HP:0001404)3.05405629
32Agnosia (HP:0010524)3.03699266
33Meckel diverticulum (HP:0002245)3.00791372
34Ragged-red muscle fibers (HP:0003200)2.99918220
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98485653
36Absent thumb (HP:0009777)2.97570087
37Hyperthyroidism (HP:0000836)2.96460798
38Aplasia/Hypoplasia of the patella (HP:0006498)2.93130861
39Abnormality of the ileum (HP:0001549)2.90377898
40Myopathic facies (HP:0002058)2.87029381
41Unilateral renal agenesis (HP:0000122)2.84932220
42Increased serum pyruvate (HP:0003542)2.83625127
43Abnormality of glycolysis (HP:0004366)2.83625127
44Carpal bone hypoplasia (HP:0001498)2.77090594
45Progressive muscle weakness (HP:0003323)2.75170046
46Respiratory difficulties (HP:0002880)2.74813966
4711 pairs of ribs (HP:0000878)2.73814603
48Increased intramyocellular lipid droplets (HP:0012240)2.72939453
49Increased serum lactate (HP:0002151)2.70806972
50Abnormality of chromosome stability (HP:0003220)2.69845697
51Macrocytic anemia (HP:0001972)2.69391070
52Abnormal number of incisors (HP:0011064)2.68915529
53Stridor (HP:0010307)2.68454260
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.67794800
55Increased CSF lactate (HP:0002490)2.64813070
56Cerebellar dysplasia (HP:0007033)2.64163178
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63560194
58Hypoplastic heart (HP:0001961)2.62045897
59Broad distal phalanx of finger (HP:0009836)2.61360544
60Mitochondrial inheritance (HP:0001427)2.59952922
61Rough bone trabeculation (HP:0100670)2.55599550
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53647566
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53647566
64Abnormality of alanine metabolism (HP:0010916)2.53466869
65Hyperalaninemia (HP:0003348)2.53466869
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53466869
67Microvesicular hepatic steatosis (HP:0001414)2.49632412
68Pallor (HP:0000980)2.49243289
69Anomalous pulmonary venous return (HP:0010772)2.46347251
70Lipid accumulation in hepatocytes (HP:0006561)2.45800730
71Rhabdomyosarcoma (HP:0002859)2.43209512
72Small intestinal stenosis (HP:0012848)2.42719987
73Duodenal stenosis (HP:0100867)2.42719987
74Hepatic necrosis (HP:0002605)2.42521430
75Supernumerary spleens (HP:0009799)2.38358217
76Absent radius (HP:0003974)2.37686569
77Abnormality of the tricuspid valve (HP:0001702)2.35786152
78Neoplasm of the pancreas (HP:0002894)2.35432607
79Myelodysplasia (HP:0002863)2.35188970
80Rectal prolapse (HP:0002035)2.34243303
81Bulbar palsy (HP:0001283)2.32455853
82Skin pits (HP:0100276)2.32040804
83Abnormality of the parathyroid morphology (HP:0011766)2.31772181
84Acute necrotizing encephalopathy (HP:0006965)2.30872698
85Sloping forehead (HP:0000340)2.29696663
86Trismus (HP:0000211)2.29385029
87Annular pancreas (HP:0001734)2.28314095
88Abnormal mitochondria in muscle tissue (HP:0008316)2.27992534
89Horseshoe kidney (HP:0000085)2.26938548
90Abdominal situs inversus (HP:0003363)2.26003367
91Abnormality of abdominal situs (HP:0011620)2.26003367
92Impulsivity (HP:0100710)2.25448012
93Emotional lability (HP:0000712)2.24123772
94Premature graying of hair (HP:0002216)2.23095157
95Microretrognathia (HP:0000308)2.22537914
96Bone marrow hypocellularity (HP:0005528)2.21422238
97Aplasia involving forearm bones (HP:0009822)2.21160590
98Absent forearm bone (HP:0003953)2.21160590
99Neoplasm of the adrenal cortex (HP:0100641)2.20044245
100Shoulder girdle muscle weakness (HP:0003547)2.19251344
101Atelectasis (HP:0100750)2.17978730
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17455669
103Hypertensive crisis (HP:0100735)2.17123124
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16454023
105Seborrheic dermatitis (HP:0001051)2.15614284
106Panhypogammaglobulinemia (HP:0003139)2.13802310
107Atrophy/Degeneration involving motor neurons (HP:0007373)2.12802874
108Basal cell carcinoma (HP:0002671)2.11534647
109Abnormal lung lobation (HP:0002101)2.11286181
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11114185
111Abnormality of the astrocytes (HP:0100707)2.09643183
112Astrocytoma (HP:0009592)2.09643183
113Tetany (HP:0001281)2.09634879
114Sclerocornea (HP:0000647)2.08439257
115CNS hypomyelination (HP:0003429)2.07754064
116Bowel incontinence (HP:0002607)2.07520611
117Amblyopia (HP:0000646)2.07465409
118Down-sloping shoulders (HP:0200021)2.04486775
119Sparse lateral eyebrow (HP:0005338)2.03384161
120Abnormality of the duodenum (HP:0002246)2.02006967
121Subaortic stenosis (HP:0001682)2.01730872
122Abnormality of the left ventricular outflow tract (HP:0011103)2.01730872
123Abnormal large intestine physiology (HP:0012700)2.01011285
124Hypoplasia of the pons (HP:0012110)1.99816236
125Neoplasm of the colon (HP:0100273)1.98385021
126Triphalangeal thumb (HP:0001199)1.98226980
127Tracheoesophageal fistula (HP:0002575)1.98104440
128Abnormal umbilical cord blood vessels (HP:0011403)1.96107698
129Single umbilical artery (HP:0001195)1.96107698
130Abnormality of the fetal cardiovascular system (HP:0010948)1.96107698
131Abnormality of pyrimidine metabolism (HP:0004353)1.95502528
132Missing ribs (HP:0000921)1.95147433
133Glioma (HP:0009733)1.95007354
134Cellular immunodeficiency (HP:0005374)1.93514082
135Abnormality of homocysteine metabolism (HP:0010919)1.93163137
136Homocystinuria (HP:0002156)1.93163137
137Premature ovarian failure (HP:0008209)1.93116535
138Abnormality of DNA repair (HP:0003254)1.93067485
139Abnormality of the pulmonary veins (HP:0011718)1.92653177
140Rimmed vacuoles (HP:0003805)1.91831242
141Self-mutilation (HP:0000742)1.91133213
142Nasal speech (HP:0001611)1.91094705
143Cafe-au-lait spot (HP:0000957)1.90890809
144Unsteady gait (HP:0002317)1.90608234
145Muscle fiber atrophy (HP:0100295)1.90158428
146Cleft eyelid (HP:0000625)1.90038225
147Cortical visual impairment (HP:0100704)1.89466252
148Postnatal microcephaly (HP:0005484)1.89354841
149Angiofibromas (HP:0010615)1.89083838
150Adenoma sebaceum (HP:0009720)1.89083838
151Hypergonadotropic hypogonadism (HP:0000815)1.88872823
152Pelvic girdle muscle weakness (HP:0003749)1.87040709
153Cholelithiasis (HP:0001081)1.85993436
154Tongue fasciculations (HP:0001308)1.85685330
155Redundant skin (HP:0001582)1.85327582
156Abnormally folded helix (HP:0008544)1.84944174
157Exercise intolerance (HP:0003546)1.84649318
158Abnormality of the columella (HP:0009929)1.84200632
159Lactic acidosis (HP:0003128)1.83575249
160Nephroblastoma (Wilms tumor) (HP:0002667)1.83525402
161High anterior hairline (HP:0009890)1.83464277
162Aplasia/Hypoplasia affecting the retina (HP:0008061)1.83188542
163Overfolded helix (HP:0000396)1.83050163
164CNS demyelination (HP:0007305)1.80002895
165Increased hepatocellular lipid droplets (HP:0006565)1.79566676
166Neoplasm of striated muscle (HP:0009728)1.78199687
167Insomnia (HP:0100785)1.77898921
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75941372
169Pulmonary artery stenosis (HP:0004415)1.75111052
170Hepatitis (HP:0012115)1.74405857
171Hyperacusis (HP:0010780)1.74325208
172Muscle stiffness (HP:0003552)1.72747903
173Spinal canal stenosis (HP:0003416)1.72326827
174Acute encephalopathy (HP:0006846)1.71006612
175Slender long bone (HP:0003100)1.68814432
176Spinal cord lesions (HP:0100561)1.68261803
177Syringomyelia (HP:0003396)1.68261803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG16.22846223
2BUB14.98644145
3VRK24.53409378
4TAF14.39975004
5CDC74.14388303
6WEE13.88003834
7EIF2AK13.28182582
8TSSK63.13528463
9SRPK13.00273358
10NEK12.90160600
11ACVR1B2.84301019
12TRIB32.81740587
13STK162.51677157
14PRKD32.48928412
15TLK12.47861289
16CCNB12.32910662
17ICK2.20077006
18NME22.12202793
19TTK2.11142631
20MAPKAPK52.10354252
21NEK21.97853693
22PDK41.93774033
23PDK31.93774033
24PLK11.87095809
25BRSK21.86041195
26PASK1.83222497
27MAPK111.79282938
28VRK11.76100155
29SCYL21.68854481
30ATR1.61614153
31EIF2AK31.61105451
32PLK31.58469886
33IRAK31.55966441
34PLK41.50897211
35AURKA1.45011435
36TGFBR11.43194288
37CHEK21.43143723
38MKNK11.42523930
39TESK21.42061354
40NTRK21.38760274
41PNCK1.38403150
42AURKB1.36328405
43BRSK11.36053641
44NME11.35316065
45CDK71.33333202
46RPS6KB21.28302892
47MAP2K31.26424000
48ERN11.22830271
49CSNK1G31.22231888
50CHEK11.16123634
51EEF2K1.15870981
52ZAK1.15569275
53CSNK1A1L1.15314063
54BRAF1.11205749
55MKNK21.11120254
56DAPK11.10932585
57TESK11.09964770
58BLK1.06831131
59MAP2K21.05102238
60MAPK121.04741234
61CAMKK11.04700119
62FLT31.00003684
63CDK90.97254463
64CAMKK20.95213505
65PAK40.94673807
66DYRK30.92502856
67EPHA20.91539882
68MAP3K80.91184383
69MAP4K10.89057019
70CSNK1G10.88690086
71NUAK10.88545872
72CDK40.84569320
73CAMK1D0.84301509
74PRPF4B0.84101151
75PDK20.82417226
76TNK20.81952562
77CSNK2A20.80533700
78SIK20.80271309
79CSNK1G20.79350076
80MAP3K110.78770634
81MAP2K70.77539951
82ATM0.76642691
83CDK20.76481665
84ALK0.74001150
85HIPK20.71002270
86RPS6KA50.70967059
87GRK50.69469022
88PIM20.68117294
89PAK10.67399921
90CDK80.67140043
91CSNK2A10.66861523
92MAPKAPK30.66480352
93MAP2K40.65540537
94CDK190.65040671
95RPS6KA40.63537449
96WNK40.60271369
97PRKCI0.60070535
98PIM10.59829337
99MARK20.59618857
100GRK60.59351226
101MAPK40.59259336
102LIMK10.59250098
103IRAK20.58775476
104MTOR0.56749019
105CDK10.56348997
106STK110.56110343
107DYRK1A0.54889862
108MAP3K100.54469502
109STK40.50382580
110CAMK40.47704009
111FGFR40.46495010
112PLK20.46198701
113CAMK10.44047741
114MAP3K120.44018762
115AKT30.42181028
116BCKDK0.40645083
117DYRK20.40638416
118MAP3K70.40215463
119TTN0.39671838
120CSNK1E0.38515586
121PBK0.37931439
122MAP3K40.35731301
123ARAF0.33996150
124CASK0.33683615
125PHKG20.33145870
126PHKG10.33145870
127ILK0.33035758
128PKN20.33019613
129STK100.32931372
130RPS6KB10.32331786
131EIF2AK20.31304297
132KDR0.30997328
133CDK120.30824195
134RAF10.30739390
135PDPK10.30587199
136PRKDC0.30497129
137CDK180.30026290
138CSNK1A10.29883169
139DAPK30.28724319
140PRKAA10.27472487
141PINK10.27396573
142CDK11A0.27344320
143TAOK20.27179559
144RPS6KL10.26775167
145RPS6KC10.26775167
146AKT20.26121671
147PRKCQ0.25952099
148CDK150.25718647
149RPS6KA10.24940545
150CDK140.24908590
151MELK0.23710637
152KSR10.23575854
153MAPK80.22794506
154BRD40.22296405
155MINK10.21871784
156OBSCN0.21869003

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99086389
2Mismatch repair_Homo sapiens_hsa034304.29016920
3Proteasome_Homo sapiens_hsa030503.81713264
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76501082
5Ribosome_Homo sapiens_hsa030103.66714267
6Spliceosome_Homo sapiens_hsa030403.31371002
7RNA transport_Homo sapiens_hsa030133.13625602
8RNA polymerase_Homo sapiens_hsa030203.12655729
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.10397399
10Base excision repair_Homo sapiens_hsa034103.02177736
11Homologous recombination_Homo sapiens_hsa034402.93909032
12Nucleotide excision repair_Homo sapiens_hsa034202.88729609
13One carbon pool by folate_Homo sapiens_hsa006702.57522692
14Cell cycle_Homo sapiens_hsa041102.51875519
15Pyrimidine metabolism_Homo sapiens_hsa002402.46852789
16Fanconi anemia pathway_Homo sapiens_hsa034602.21430529
17Non-homologous end-joining_Homo sapiens_hsa034501.96832508
18Sulfur metabolism_Homo sapiens_hsa009201.96769151
19RNA degradation_Homo sapiens_hsa030181.86066270
20Basal transcription factors_Homo sapiens_hsa030221.85623933
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77216264
22mRNA surveillance pathway_Homo sapiens_hsa030151.69586806
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53157447
24Parkinsons disease_Homo sapiens_hsa050121.49710592
25Purine metabolism_Homo sapiens_hsa002301.49346483
26Huntingtons disease_Homo sapiens_hsa050161.34168950
27Oxidative phosphorylation_Homo sapiens_hsa001901.33716103
28Biosynthesis of amino acids_Homo sapiens_hsa012301.26727811
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23030476
30Systemic lupus erythematosus_Homo sapiens_hsa053221.22003611
31Oocyte meiosis_Homo sapiens_hsa041141.21823280
32Epstein-Barr virus infection_Homo sapiens_hsa051691.12581790
33p53 signaling pathway_Homo sapiens_hsa041151.12578008
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10494008
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.08335311
36Arginine biosynthesis_Homo sapiens_hsa002201.04574587
37Carbon metabolism_Homo sapiens_hsa012001.01200955
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.99573153
39Lysine degradation_Homo sapiens_hsa003100.98998805
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98735370
41Sulfur relay system_Homo sapiens_hsa041220.93120151
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91171288
43Protein export_Homo sapiens_hsa030600.89089821
44Pentose phosphate pathway_Homo sapiens_hsa000300.87774478
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85536982
46Other glycan degradation_Homo sapiens_hsa005110.77829857
47Viral carcinogenesis_Homo sapiens_hsa052030.76844771
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72669168
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71304878
50Alzheimers disease_Homo sapiens_hsa050100.69693923
51Pyruvate metabolism_Homo sapiens_hsa006200.68960944
52Fructose and mannose metabolism_Homo sapiens_hsa000510.68675491
53Alcoholism_Homo sapiens_hsa050340.67942337
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.66823178
55Non-small cell lung cancer_Homo sapiens_hsa052230.63220490
56Folate biosynthesis_Homo sapiens_hsa007900.60282012
57Regulation of autophagy_Homo sapiens_hsa041400.58029161
58Antigen processing and presentation_Homo sapiens_hsa046120.57910983
59Thyroid cancer_Homo sapiens_hsa052160.56685687
60Chronic myeloid leukemia_Homo sapiens_hsa052200.55495831
61N-Glycan biosynthesis_Homo sapiens_hsa005100.54527605
62Herpes simplex infection_Homo sapiens_hsa051680.53868282
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52860118
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52167575
65Selenocompound metabolism_Homo sapiens_hsa004500.52038833
66HTLV-I infection_Homo sapiens_hsa051660.51897495
67Acute myeloid leukemia_Homo sapiens_hsa052210.48678266
68Vitamin B6 metabolism_Homo sapiens_hsa007500.45153600
69Phenylalanine metabolism_Homo sapiens_hsa003600.44518947
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44485133
71Galactose metabolism_Homo sapiens_hsa000520.42977228
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.42557989
73Pancreatic cancer_Homo sapiens_hsa052120.42248448
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41481358
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40385141
76Cardiac muscle contraction_Homo sapiens_hsa042600.40245046
77Legionellosis_Homo sapiens_hsa051340.37602219
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34617583
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34348184
80Metabolic pathways_Homo sapiens_hsa011000.33182867
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32631993
82AMPK signaling pathway_Homo sapiens_hsa041520.31508790
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30866048
84Glutathione metabolism_Homo sapiens_hsa004800.30085913
85Fatty acid elongation_Homo sapiens_hsa000620.30003096
86Colorectal cancer_Homo sapiens_hsa052100.29631844
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.29337341
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27907595
89Melanogenesis_Homo sapiens_hsa049160.26434092
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26082529
91Glycerolipid metabolism_Homo sapiens_hsa005610.25409787
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24924813
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24830436
94Insulin signaling pathway_Homo sapiens_hsa049100.24126727
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24032241
96HIF-1 signaling pathway_Homo sapiens_hsa040660.20419379
97Vibrio cholerae infection_Homo sapiens_hsa051100.19158134
98Hippo signaling pathway_Homo sapiens_hsa043900.15739635
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15101743
100Basal cell carcinoma_Homo sapiens_hsa052170.14904357
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14838590
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13826532
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12763786
104MicroRNAs in cancer_Homo sapiens_hsa052060.12355359
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11203765
106Hedgehog signaling pathway_Homo sapiens_hsa043400.09075324
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08183290
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07475620
109Arginine and proline metabolism_Homo sapiens_hsa003300.06983095
110Bladder cancer_Homo sapiens_hsa052190.04042157
111Apoptosis_Homo sapiens_hsa042100.03971219
112Primary immunodeficiency_Homo sapiens_hsa053400.03483456
113Small cell lung cancer_Homo sapiens_hsa052220.03199238
114Renin-angiotensin system_Homo sapiens_hsa046140.02934271
115Wnt signaling pathway_Homo sapiens_hsa043100.02541052
116TGF-beta signaling pathway_Homo sapiens_hsa043500.01059616
117Influenza A_Homo sapiens_hsa05164-0.0517346
118Hepatitis B_Homo sapiens_hsa05161-0.0425611
119Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0399112
120Shigellosis_Homo sapiens_hsa05131-0.0368023
121Glucagon signaling pathway_Homo sapiens_hsa04922-0.0282683
122Notch signaling pathway_Homo sapiens_hsa04330-0.0203818
123Pathways in cancer_Homo sapiens_hsa05200-0.0194194
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0124941

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