PRMT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.03449157
2ribosomal small subunit assembly (GO:0000028)4.90286846
3maturation of SSU-rRNA (GO:0030490)4.80782786
4DNA strand elongation involved in DNA replication (GO:0006271)4.78989813
5DNA replication initiation (GO:0006270)4.78968973
6telomere maintenance via semi-conservative replication (GO:0032201)4.61183553
7IMP biosynthetic process (GO:0006188)4.57304001
8DNA strand elongation (GO:0022616)4.54171903
9DNA deamination (GO:0045006)4.45381512
10nucleobase biosynthetic process (GO:0046112)4.34937884
11viral transcription (GO:0019083)4.34477303
12formation of translation preinitiation complex (GO:0001731)4.30917537
13translational termination (GO:0006415)4.29081679
14IMP metabolic process (GO:0046040)4.16633264
15ribosome biogenesis (GO:0042254)4.13586198
16pore complex assembly (GO:0046931)4.09416981
17non-recombinational repair (GO:0000726)4.06000807
18double-strand break repair via nonhomologous end joining (GO:0006303)4.06000807
19telomere maintenance via recombination (GO:0000722)3.99175739
20mitotic sister chromatid segregation (GO:0000070)3.95573754
21purine nucleobase biosynthetic process (GO:0009113)3.93275450
22ribonucleoprotein complex biogenesis (GO:0022613)3.91816782
23folic acid-containing compound biosynthetic process (GO:0009396)3.91038548
24translational elongation (GO:0006414)3.90721990
25protein localization to kinetochore (GO:0034501)3.82646591
26mitotic recombination (GO:0006312)3.79242723
27telomere maintenance via telomere lengthening (GO:0010833)3.77374716
28translational initiation (GO:0006413)3.76831966
29ribosomal small subunit biogenesis (GO:0042274)3.75623566
30sister chromatid segregation (GO:0000819)3.74508476
31ribosomal large subunit biogenesis (GO:0042273)3.74505582
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73758894
33ribosome assembly (GO:0042255)3.73343259
34transcription from mitochondrial promoter (GO:0006390)3.69635820
35regulation of centriole replication (GO:0046599)3.69356053
36nuclear pore organization (GO:0006999)3.68968202
37DNA replication-dependent nucleosome organization (GO:0034723)3.68230807
38DNA replication-dependent nucleosome assembly (GO:0006335)3.68230807
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.66812865
40mitotic nuclear envelope disassembly (GO:0007077)3.66651681
41pseudouridine synthesis (GO:0001522)3.65015154
42proteasome assembly (GO:0043248)3.64715421
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64007450
44spindle checkpoint (GO:0031577)3.63893179
45mitotic spindle checkpoint (GO:0071174)3.63735842
46nuclear pore complex assembly (GO:0051292)3.61404077
47maturation of 5.8S rRNA (GO:0000460)3.59659164
48regulation of spindle organization (GO:0090224)3.58793554
49mitotic spindle assembly checkpoint (GO:0007094)3.57477066
50tRNA aminoacylation for protein translation (GO:0006418)3.53035816
51replication fork processing (GO:0031297)3.52525926
52spindle assembly checkpoint (GO:0071173)3.52336886
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51722502
54DNA duplex unwinding (GO:0032508)3.51709493
55DNA replication checkpoint (GO:0000076)3.51686628
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.51353076
57DNA ligation (GO:0006266)3.51346116
58amino acid activation (GO:0043038)3.51025128
59tRNA aminoacylation (GO:0043039)3.51025128
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50029469
61DNA geometric change (GO:0032392)3.49179911
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.44775957
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.44775957
64translesion synthesis (GO:0019985)3.44672959
65CENP-A containing nucleosome assembly (GO:0034080)3.44484108
66chromatin remodeling at centromere (GO:0031055)3.43710041
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41251268
68rRNA modification (GO:0000154)3.41071194
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40689387
70membrane disassembly (GO:0030397)3.40007109
71nuclear envelope disassembly (GO:0051081)3.40007109
72cotranslational protein targeting to membrane (GO:0006613)3.39570978
73kinetochore organization (GO:0051383)3.38648592
74protein targeting to ER (GO:0045047)3.38544814
75rRNA processing (GO:0006364)3.37217244
76regulation of sister chromatid segregation (GO:0033045)3.36275204
77regulation of mitotic sister chromatid separation (GO:0010965)3.36275204
78regulation of mitotic sister chromatid segregation (GO:0033047)3.36275204
79DNA replication-independent nucleosome organization (GO:0034724)3.35570877
80DNA replication-independent nucleosome assembly (GO:0006336)3.35570877
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.33716542
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33716542
83viral life cycle (GO:0019058)3.32549170
84regulation of chromosome segregation (GO:0051983)3.31903810
85cellular protein complex disassembly (GO:0043624)3.31500472
86mitotic chromosome condensation (GO:0007076)3.30617757
87rRNA methylation (GO:0031167)3.27792558
88regulation of centrosome cycle (GO:0046605)3.27496227
89mitochondrial RNA metabolic process (GO:0000959)3.27489796
90pteridine-containing compound biosynthetic process (GO:0042559)3.27212247
91mitotic metaphase plate congression (GO:0007080)3.26718828
92rRNA metabolic process (GO:0016072)3.26467262
93DNA double-strand break processing (GO:0000729)3.24319193
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23950127
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23159592
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22756633
97negative regulation of ligase activity (GO:0051352)3.22756633
98establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22423987
99establishment of viral latency (GO:0019043)3.21800838
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20936803
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19313063
102protein localization to chromosome, centromeric region (GO:0071459)3.18531880
103protein localization to endoplasmic reticulum (GO:0070972)3.17183260
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16999815
105DNA catabolic process, exonucleolytic (GO:0000738)3.16830786
106kinetochore assembly (GO:0051382)3.15265230
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13518418
108telomere maintenance (GO:0000723)3.12884808
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11873807
110telomere organization (GO:0032200)3.11636900
111negative regulation of RNA splicing (GO:0033119)3.11275231
112tetrahydrofolate metabolic process (GO:0046653)3.10890846
113metaphase plate congression (GO:0051310)3.08584844
114mitochondrial DNA replication (GO:0006264)3.07550645
115protein complex disassembly (GO:0043241)3.06818620
116nuclear-transcribed mRNA catabolic process (GO:0000956)3.06394164
117DNA topological change (GO:0006265)3.04924946
118postreplication repair (GO:0006301)3.03503087
119G1/S transition of mitotic cell cycle (GO:0000082)3.03349914
120cell cycle G1/S phase transition (GO:0044843)3.03349914
121regulation of sister chromatid cohesion (GO:0007063)3.02953338
122regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02586064
123regulation of mitotic spindle checkpoint (GO:1903504)3.02586064
124protein complex localization (GO:0031503)3.02278541
125transcription-coupled nucleotide-excision repair (GO:0006283)3.01580409
126regulation of histone H3-K9 methylation (GO:0051570)2.95264781
127tRNA methylation (GO:0030488)2.95232145
128mitochondrial DNA metabolic process (GO:0032042)2.94236802
129spliceosomal snRNP assembly (GO:0000387)2.94139656
130establishment of integrated proviral latency (GO:0075713)2.93689767
131meiotic chromosome segregation (GO:0045132)2.93561922
132RNA catabolic process (GO:0006401)2.93444012
133mismatch repair (GO:0006298)2.92448753
134mRNA catabolic process (GO:0006402)2.91969767
135chromatin assembly or disassembly (GO:0006333)2.90629373
136macromolecular complex disassembly (GO:0032984)2.89263814
137cellular component biogenesis (GO:0044085)2.89209657
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87001069
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87001069
140isotype switching (GO:0045190)2.87001069
141regulation of translational fidelity (GO:0006450)2.85256369
142dosage compensation (GO:0007549)2.84817043
143viral mRNA export from host cell nucleus (GO:0046784)2.83371161
144base-excision repair (GO:0006284)2.81860904
145histone exchange (GO:0043486)2.81189837
146negative regulation of chromosome segregation (GO:0051985)2.81039007
147regulation of translation in response to stress (GO:0043555)2.80185257
148mitotic sister chromatid cohesion (GO:0007064)2.79990581
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77905813
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77905813
151negative regulation of sister chromatid segregation (GO:0033046)2.77905813
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.77905813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.21358864
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.51022750
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82557472
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57976904
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.33977363
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04958619
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85079823
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83665096
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81867820
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.52739090
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.45809471
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.44468979
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38730596
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35256517
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34014324
16XRN2_22483619_ChIP-Seq_HELA_Human2.27031273
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22456025
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17286842
19MYC_22102868_ChIP-Seq_BL_Human2.16577994
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.14430334
21* VDR_23849224_ChIP-Seq_CD4+_Human2.08229197
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.05709443
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01378418
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98738265
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93900912
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89508913
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87397241
28FOXP3_21729870_ChIP-Seq_TREG_Human1.87225715
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86947910
30CIITA_25753668_ChIP-Seq_RAJI_Human1.86867432
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85907017
32AR_21909140_ChIP-Seq_LNCAP_Human1.82518374
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78069587
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75151663
35TTF2_22483619_ChIP-Seq_HELA_Human1.74417451
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71805893
37GABP_19822575_ChIP-Seq_HepG2_Human1.71649308
38DCP1A_22483619_ChIP-Seq_HELA_Human1.70440900
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67648316
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66346039
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65134140
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64867927
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64010556
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60641757
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.59775295
46VDR_21846776_ChIP-Seq_THP-1_Human1.58353899
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52238342
48ELK1_19687146_ChIP-ChIP_HELA_Human1.48517423
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47910830
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47189480
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46020580
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45966051
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45549297
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45087964
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43109483
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42136914
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41313001
58KDM5A_27292631_Chip-Seq_BREAST_Human1.39854657
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38935963
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35027902
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33580338
62SCL_19346495_ChIP-Seq_HPC-7_Human1.29883802
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29762053
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29098352
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27275861
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.22977098
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22486598
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21363380
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20922439
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18364103
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17257753
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16715756
73SPI1_23547873_ChIP-Seq_NB4_Human1.14457424
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13464367
75* TFEB_21752829_ChIP-Seq_HELA_Human1.11989688
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.11824537
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10691229
78EWS_26573619_Chip-Seq_HEK293_Human1.08951612
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04779073
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01540013
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01083019
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00757905
83* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00316578
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98962563
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98196322
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.97779419
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96870455
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95078629
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94301721
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.93914414
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93307311
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92855984
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.92429277
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92011726
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91882735
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91308555
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89458688
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89335215
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87242345
100FUS_26573619_Chip-Seq_HEK293_Human0.87201472
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87105872
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86494373
103CHD1_26751641_Chip-Seq_LNCaP_Human0.85324210
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84924234
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84589735
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84589735
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84589735
108MYC_18940864_ChIP-ChIP_HL60_Human0.83550367
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83016551
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.82056380
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.81896505
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81701412
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.81053730
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80953872
115* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80034573
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79106599
117ZNF263_19887448_ChIP-Seq_K562_Human0.79030932
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75153286
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74240651
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73950518
121ELF5_23300383_ChIP-Seq_T47D_Human0.72000769
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.63752549
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.63543574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78307505
2MP0010094_abnormal_chromosome_stability4.60714239
3MP0004957_abnormal_blastocyst_morpholog4.13906500
4MP0003111_abnormal_nucleus_morphology4.01488185
5MP0008057_abnormal_DNA_replication3.73836029
6MP0003077_abnormal_cell_cycle3.70090526
7MP0002396_abnormal_hematopoietic_system3.63834500
8MP0008058_abnormal_DNA_repair3.26059618
9MP0009697_abnormal_copulation3.04693631
10MP0010352_gastrointestinal_tract_polyps2.76213191
11MP0008007_abnormal_cellular_replicative2.54176640
12MP0008932_abnormal_embryonic_tissue2.22246613
13MP0000350_abnormal_cell_proliferation2.19860367
14MP0000490_abnormal_crypts_of2.09576356
15MP0001730_embryonic_growth_arrest2.07982124
16MP0004808_abnormal_hematopoietic_stem2.07452702
17MP0010307_abnormal_tumor_latency1.91884920
18MP0003123_paternal_imprinting1.89582685
19MP0003941_abnormal_skin_development1.84419536
20MP0002019_abnormal_tumor_incidence1.71674586
21MP0003786_premature_aging1.68277347
22MP0005380_embryogenesis_phenotype1.67406950
23MP0001672_abnormal_embryogenesis/_devel1.67406950
24MP0009333_abnormal_splenocyte_physiolog1.66866270
25* MP0001697_abnormal_embryo_size1.66352912
26MP0001545_abnormal_hematopoietic_system1.65396145
27MP0005397_hematopoietic_system_phenotyp1.65396145
28MP0003763_abnormal_thymus_physiology1.64534771
29MP0002080_prenatal_lethality1.60917962
30MP0000313_abnormal_cell_death1.59297067
31MP0000703_abnormal_thymus_morphology1.58567492
32MP0002398_abnormal_bone_marrow1.56096868
33MP0003984_embryonic_growth_retardation1.52992866
34MP0008877_abnormal_DNA_methylation1.51998302
35MP0003567_abnormal_fetal_cardiomyocyte1.51952183
36MP0006054_spinal_hemorrhage1.50449944
37MP0002088_abnormal_embryonic_growth/wei1.49490910
38MP0002086_abnormal_extraembryonic_tissu1.49267863
39MP0004197_abnormal_fetal_growth/weight/1.48427468
40MP0004147_increased_porphyrin_level1.47073414
41MP0002722_abnormal_immune_system1.45055015
42MP0002084_abnormal_developmental_patter1.43214434
43MP0000689_abnormal_spleen_morphology1.41246820
44MP0005075_abnormal_melanosome_morpholog1.40726708
45MP0005174_abnormal_tail_pigmentation1.39420128
46MP0002085_abnormal_embryonic_tissue1.39209310
47MP0003221_abnormal_cardiomyocyte_apopto1.37781493
48MP0006036_abnormal_mitochondrial_physio1.37515562
49MP0001853_heart_inflammation1.33642961
50MP0002009_preneoplasia1.28632847
51MP0002095_abnormal_skin_pigmentation1.27828829
52MP0003806_abnormal_nucleotide_metabolis1.22864860
53MP0000465_gastrointestinal_hemorrhage1.18261325
54MP0000358_abnormal_cell_content/1.16997138
55MP0001293_anophthalmia1.16715364
56MP0002429_abnormal_blood_cell1.16526973
57MP0000716_abnormal_immune_system1.05240732
58MP0001661_extended_life_span1.04294153
59MP0003566_abnormal_cell_adhesion0.99965021
60MP0009703_decreased_birth_body0.99879266
61MP0000372_irregular_coat_pigmentation0.98777221
62MP0003656_abnormal_erythrocyte_physiolo0.98175340
63MP0005266_abnormal_metabolism0.96681770
64MP0000537_abnormal_urethra_morphology0.93883544
65MP0004233_abnormal_muscle_weight0.93471362
66MP0001873_stomach_inflammation0.92794116
67MP0001529_abnormal_vocalization0.92075331
68MP0005023_abnormal_wound_healing0.91725660
69MP0002210_abnormal_sex_determination0.91488631
70MP0001145_abnormal_male_reproductive0.91260478
71MP0001346_abnormal_lacrimal_gland0.89833995
72MP0001835_abnormal_antigen_presentation0.89643754
73MP0001915_intracranial_hemorrhage0.89506627
74MP0001800_abnormal_humoral_immune0.88979000
75MP0000685_abnormal_immune_system0.88882181
76MP0002075_abnormal_coat/hair_pigmentati0.88826773
77MP0002877_abnormal_melanocyte_morpholog0.86872736
78MP0002420_abnormal_adaptive_immunity0.86183897
79MP0001819_abnormal_immune_cell0.85302281
80MP0003121_genomic_imprinting0.85060824
81MP0002405_respiratory_system_inflammati0.84745946
82MP0009278_abnormal_bone_marrow0.84619668
83MP0003718_maternal_effect0.84317300
84MP0000371_diluted_coat_color0.83028477
85MP0005384_cellular_phenotype0.81949039
86MP0005501_abnormal_skin_physiology0.81759988
87MP0002166_altered_tumor_susceptibility0.81375585
88MP0002452_abnormal_antigen_presenting0.81102149
89MP0005671_abnormal_response_to0.79264088
90MP0002160_abnormal_reproductive_system0.75679652
91MP0000858_altered_metastatic_potential0.75528921
92MP0000015_abnormal_ear_pigmentation0.75463555
93MP0005621_abnormal_cell_physiology0.73962021
94MP0001119_abnormal_female_reproductive0.73679533
95MP0000477_abnormal_intestine_morphology0.72914935
96MP0004185_abnormal_adipocyte_glucose0.72703454
97MP0005408_hypopigmentation0.72698392
98MP0001881_abnormal_mammary_gland0.71948346
99MP0002006_tumorigenesis0.71459572
100MP0008770_decreased_survivor_rate0.71135623
101MP0000653_abnormal_sex_gland0.70928204
102MP0000647_abnormal_sebaceous_gland0.70207575
103MP0001286_abnormal_eye_development0.69748822
104MP0002723_abnormal_immune_serum0.69745599
105MP0010030_abnormal_orbit_morphology0.68892018
106MP0002132_abnormal_respiratory_system0.68437745
107MP0005464_abnormal_platelet_physiology0.68159746
108MP0002111_abnormal_tail_morphology0.67841159
109MP0010155_abnormal_intestine_physiology0.67427382
110MP0003937_abnormal_limbs/digits/tail_de0.66272889
111MP0000579_abnormal_nail_morphology0.66229395
112MP0003186_abnormal_redox_activity0.66065197
113MP0001929_abnormal_gametogenesis0.65062342
114MP0002697_abnormal_eye_size0.64553631
115MP0005076_abnormal_cell_differentiation0.64363865
116MP0009672_abnormal_birth_weight0.63737061
117MP0003950_abnormal_plasma_membrane0.63565082
118MP0002796_impaired_skin_barrier0.63358056
119MP0002163_abnormal_gland_morphology0.63015960
120MP0006035_abnormal_mitochondrial_morpho0.62373455
121MP0002938_white_spotting0.61461486
122MP0000733_abnormal_muscle_development0.60798959
123MP0006072_abnormal_retinal_apoptosis0.60454021
124MP0001727_abnormal_embryo_implantation0.59430296
125MP0003315_abnormal_perineum_morphology0.58808665
126MP0000627_abnormal_mammary_gland0.58764822
127MP0001849_ear_inflammation0.58219880
128MP0004782_abnormal_surfactant_physiolog0.56630276
129MP0005395_other_phenotype0.55940320
130MP0003699_abnormal_female_reproductive0.55887450
131MP0009379_abnormal_foot_pigmentation0.55794235
132MP0002269_muscular_atrophy0.54681057
133MP0002092_abnormal_eye_morphology0.54379898
134MP0000747_muscle_weakness0.54181972
135MP0003943_abnormal_hepatobiliary_system0.53905929
136MP0006292_abnormal_olfactory_placode0.53239020
137MP0000427_abnormal_hair_cycle0.52959867
138MP0003890_abnormal_embryonic-extraembry0.52875220
139MP0003698_abnormal_male_reproductive0.52840304
140MP0004084_abnormal_cardiac_muscle0.50028427
141MP0010234_abnormal_vibrissa_follicle0.49020070
142MP0000749_muscle_degeneration0.48595754
143MP0010678_abnormal_skin_adnexa0.48182878
144MP0002751_abnormal_autonomic_nervous0.47705930

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.84015799
2Abnormal number of erythroid precursors (HP:0012131)4.61895918
3Reticulocytopenia (HP:0001896)4.45811285
4Increased serum pyruvate (HP:0003542)4.07555473
5Aplastic anemia (HP:0001915)4.07478213
6Abnormality of glycolysis (HP:0004366)4.06440767
7Colon cancer (HP:0003003)3.94847369
8Birth length less than 3rd percentile (HP:0003561)3.80118233
9Oral leukoplakia (HP:0002745)3.76190713
10Selective tooth agenesis (HP:0001592)3.69522894
11Agnosia (HP:0010524)3.59612786
12Ependymoma (HP:0002888)3.45135794
13IgM deficiency (HP:0002850)3.29913314
14Medulloblastoma (HP:0002885)3.19572395
15Basal cell carcinoma (HP:0002671)3.15611365
16Thrombocytosis (HP:0001894)3.03970294
17Pallor (HP:0000980)3.00900093
18Rough bone trabeculation (HP:0100670)2.96842660
19Neoplasm of the oral cavity (HP:0100649)2.92069035
20Nephroblastoma (Wilms tumor) (HP:0002667)2.87429827
21Myelodysplasia (HP:0002863)2.86216586
22Chromsome breakage (HP:0040012)2.83477754
23Abnormality of alanine metabolism (HP:0010916)2.81145988
24Hyperalaninemia (HP:0003348)2.81145988
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81145988
26Absent thumb (HP:0009777)2.75242522
27Abnormality of the anterior horn cell (HP:0006802)2.72592869
28Degeneration of anterior horn cells (HP:0002398)2.72592869
29Rhabdomyosarcoma (HP:0002859)2.71609794
30Abnormality of chromosome stability (HP:0003220)2.70613052
31Macrocytic anemia (HP:0001972)2.69794343
32Increased nuchal translucency (HP:0010880)2.69631936
33Embryonal renal neoplasm (HP:0011794)2.69582291
3411 pairs of ribs (HP:0000878)2.64968298
35Carpal bone hypoplasia (HP:0001498)2.63782333
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63335596
37Abnormality of the preputium (HP:0100587)2.63060128
38Abnormality of the labia minora (HP:0012880)2.61036074
39Abnormal lung lobation (HP:0002101)2.60198460
40Amaurosis fugax (HP:0100576)2.60000640
41Multiple enchondromatosis (HP:0005701)2.58610505
42Premature graying of hair (HP:0002216)2.54377910
43Increased serum lactate (HP:0002151)2.53089645
44Squamous cell carcinoma (HP:0002860)2.52708106
45Reduced antithrombin III activity (HP:0001976)2.52303653
46Acute encephalopathy (HP:0006846)2.48810761
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47552013
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47552013
49Abnormality of methionine metabolism (HP:0010901)2.46364431
50Abnormal number of incisors (HP:0011064)2.44994857
51Ragged-red muscle fibers (HP:0003200)2.40365129
52Breast hypoplasia (HP:0003187)2.38529266
53Abnormality of the duodenum (HP:0002246)2.37503734
54Increased CSF lactate (HP:0002490)2.31972506
55Acute necrotizing encephalopathy (HP:0006965)2.30825627
56Methylmalonic aciduria (HP:0012120)2.29803347
57Lymphoma (HP:0002665)2.27672171
58Short 5th finger (HP:0009237)2.27483760
59Neoplasm of the pancreas (HP:0002894)2.27252507
60Abnormality of the carotid arteries (HP:0005344)2.27199489
61Cerebral hypomyelination (HP:0006808)2.26715180
62Patellar aplasia (HP:0006443)2.25673002
63Astrocytoma (HP:0009592)2.24864552
64Abnormality of the astrocytes (HP:0100707)2.24864552
65Abnormal protein glycosylation (HP:0012346)2.23048771
66Abnormal glycosylation (HP:0012345)2.23048771
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23048771
68Abnormal protein N-linked glycosylation (HP:0012347)2.23048771
69Meckel diverticulum (HP:0002245)2.20373825
70Bone marrow hypocellularity (HP:0005528)2.18098516
71Prominent nose (HP:0000448)2.15900603
72Abnormality of the ileum (HP:0001549)2.14371866
73Clitoromegaly (HP:0000057)2.13317918
74Neoplasm of the adrenal gland (HP:0100631)2.12766507
75Abnormal mitochondria in muscle tissue (HP:0008316)2.11092873
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.09475276
77Aplasia/Hypoplasia of the patella (HP:0006498)2.09091863
78Glioma (HP:0009733)2.08823377
79Acute lymphatic leukemia (HP:0006721)2.08371350
80Irregular epiphyses (HP:0010582)2.07398876
81Microretrognathia (HP:0000308)2.05907660
82Progressive external ophthalmoplegia (HP:0000590)2.05632699
83Petechiae (HP:0000967)2.05558569
84Cerebral edema (HP:0002181)2.04915129
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.04317035
86Acute myeloid leukemia (HP:0004808)2.03503309
87Clubbing of toes (HP:0100760)2.03473317
88Abnormal trabecular bone morphology (HP:0100671)2.02756746
89Lipid accumulation in hepatocytes (HP:0006561)2.02464174
90Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02436377
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01283321
92Abnormality of serum amino acid levels (HP:0003112)2.00865002
93Neoplasm of striated muscle (HP:0009728)2.00574327
94Lactic acidosis (HP:0003128)2.00509660
95Increased hepatocellular lipid droplets (HP:0006565)1.98915368
96Glossoptosis (HP:0000162)1.98426612
97Pancytopenia (HP:0001876)1.97639678
98Proximal placement of thumb (HP:0009623)1.95664654
99Homocystinuria (HP:0002156)1.94591694
100Abnormality of homocysteine metabolism (HP:0010919)1.94591694
101Muscle fiber atrophy (HP:0100295)1.94306070
102Absent radius (HP:0003974)1.94068426
103Deviation of the thumb (HP:0009603)1.93072597
104Microvesicular hepatic steatosis (HP:0001414)1.92844646
105Duodenal stenosis (HP:0100867)1.92532952
106Small intestinal stenosis (HP:0012848)1.92532952
107Horseshoe kidney (HP:0000085)1.91398455
108Supernumerary spleens (HP:0009799)1.90908620
109Missing ribs (HP:0000921)1.90633507
110Volvulus (HP:0002580)1.89716702
111Syringomyelia (HP:0003396)1.87554591
112Spinal cord lesions (HP:0100561)1.87554591
113Dyschromatopsia (HP:0007641)1.87403343
114Neoplasm of the colon (HP:0100273)1.87152347
115Type 2 muscle fiber atrophy (HP:0003554)1.86825726
116High pitched voice (HP:0001620)1.86473766
117Cellular immunodeficiency (HP:0005374)1.86318306
118Chronic otitis media (HP:0000389)1.85182276
119Postnatal microcephaly (HP:0005484)1.83899452
120Abnormality of the umbilical cord (HP:0010881)1.82218103
121Trismus (HP:0000211)1.81729651
122Progressive macrocephaly (HP:0004481)1.81087411
123Sloping forehead (HP:0000340)1.80731028
124Cortical dysplasia (HP:0002539)1.80601489
125Short middle phalanx of the 5th finger (HP:0004220)1.80078647
126Cafe-au-lait spot (HP:0000957)1.79103960
127Progressive muscle weakness (HP:0003323)1.79050135
128Abnormality of the pons (HP:0007361)1.78639624
129Mitochondrial inheritance (HP:0001427)1.78605614
130Aplasia involving forearm bones (HP:0009822)1.78509543
131Absent forearm bone (HP:0003953)1.78509543
132Neuroendocrine neoplasm (HP:0100634)1.78348414
133Neoplasm of the small intestine (HP:0100833)1.78005333
134Hypoplasia of the pons (HP:0012110)1.77663692
135Impulsivity (HP:0100710)1.77405317
136Abnormality of the lower motor neuron (HP:0002366)1.77347479
137Hepatocellular necrosis (HP:0001404)1.77062799
138Tracheoesophageal fistula (HP:0002575)1.75261190
139Ovarian neoplasm (HP:0100615)1.74994340
140Type I transferrin isoform profile (HP:0003642)1.74421732
141Respiratory failure (HP:0002878)1.73933662
142Atresia of the external auditory canal (HP:0000413)1.72841317
143Abnormality of the fetal cardiovascular system (HP:0010948)1.72424601
144Abnormal umbilical cord blood vessels (HP:0011403)1.72424601
145Single umbilical artery (HP:0001195)1.72424601
146Deep philtrum (HP:0002002)1.72328393
147Pheochromocytoma (HP:0002666)1.72305763
148Absent frontal sinuses (HP:0002688)1.71451273
149Slender long bone (HP:0003100)1.70859284
150Supernumerary bones of the axial skeleton (HP:0009144)1.68630354
151Abnormality of reticulocytes (HP:0004312)1.68518585
152Overlapping toe (HP:0001845)1.67859433
153Triphalangeal thumb (HP:0001199)1.67519163
154Poikiloderma (HP:0001029)1.67507448
155Abnormalities of placenta or umbilical cord (HP:0001194)1.67383947
156Teleangiectasia of the skin (HP:0100585)1.65887313
157Central scotoma (HP:0000603)1.65433728
158Impaired proprioception (HP:0010831)1.65130991
159Megaloblastic anemia (HP:0001889)1.64925089
160Angiofibromas (HP:0010615)1.63746455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.05106145
2CDC73.89979815
3BUB13.55345392
4NME23.27732070
5PBK2.99454894
6VRK22.42486952
7MST42.38747382
8EIF2AK12.37772714
9STK162.34111679
10NEK22.29709710
11TTK2.29631171
12EEF2K2.20095356
13MKNK12.08286600
14TSSK62.03140115
15SRPK11.96354665
16TGFBR11.92932543
17RPS6KB21.91318525
18SCYL21.87610896
19JAK31.86202071
20PASK1.85620608
21ACVR1B1.85112835
22MKNK21.77381725
23ATR1.75208779
24DYRK31.72234405
25CDK71.71587673
26CDK121.70565367
27MAP3K81.70413259
28TAF11.68766612
29FLT31.67110905
30PLK11.56801153
31TLK11.56660892
32MAP4K11.56043156
33TESK21.49364349
34EIF2AK31.47577824
35VRK11.43734086
36CHEK21.43227987
37NEK11.42645944
38RPS6KA41.40408966
39AURKB1.38236473
40MAP3K101.37973255
41CDK41.35901446
42BTK1.33350479
43PKN21.33044678
44PDK21.29442841
45BRSK21.27458524
46BCR1.27444819
47NME11.23944818
48STK101.22420828
49NUAK11.15766866
50PIM11.13848017
51ERBB31.11384778
52AURKA1.08227375
53PLK41.07136606
54EPHA21.02933319
55TRIM281.02318543
56CHEK11.01508223
57ZAK0.96253732
58CCNB10.94330934
59CSF1R0.91805506
60PAK40.89943475
61KIT0.89424183
62PLK30.89118348
63MAP2K30.88391334
64TEC0.83422658
65MAP3K110.83053552
66ATM0.82377546
67LRRK20.80580671
68MAPKAPK30.80545425
69ERBB40.80506934
70PIM20.79841567
71CDK20.79264298
72PNCK0.75868025
73CSNK1A1L0.75560599
74MATK0.75432556
75STK40.70229742
76KDR0.70181185
77ALK0.69836906
78CSNK1G10.69141057
79BRD40.68662771
80PAK10.68137560
81ZAP700.67463508
82SYK0.66939897
83NEK90.66931717
84CSNK2A20.66601818
85CDK60.66445611
86BMPR20.66041408
87CDK80.64980315
88STK38L0.61809881
89BLK0.61374261
90MST1R0.58494531
91BRSK10.58297163
92FGFR10.55355911
93MAP3K50.52950053
94BMPR1B0.51311415
95MELK0.49872298
96CSNK2A10.49800753
97GRK60.49407178
98TAOK20.49170920
99CDK190.48162348
100PLK20.46918638
101CDK10.46761890
102LYN0.46475902
103SMG10.44580744
104RAF10.44328580
105LCK0.44123064
106CSNK1G20.44103914
107RPS6KB10.42392689
108AKT20.42177747
109MAPK40.38456172
110MAP3K40.38427836
111MET0.38163267
112PRKDC0.37493809
113STK240.36422140
114EIF2AK20.35767566
115RPS6KA10.35075250
116PRKCI0.31319241
117CSNK1G30.30732729
118LATS10.29972507
119STK30.29910586
120RPS6KA60.29025742
121RPS6KA50.29003469
122MAPK110.28646221
123MAP3K60.28579494
124CLK10.28277561
125CSNK1E0.27553063
126RPS6KC10.26514000
127CDK90.25222147
128NEK60.23681834
129CDK30.23547562
130CSNK1D0.17921802
131MAPK140.17886602
132BRAF0.16527145
133PAK20.15514272
134YES10.14668758
135MUSK0.13694178
136INSRR0.10908155

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.34887325
2Mismatch repair_Homo sapiens_hsa034304.41929522
3Ribosome_Homo sapiens_hsa030103.71026630
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.67133341
5Spliceosome_Homo sapiens_hsa030403.27671880
6Base excision repair_Homo sapiens_hsa034103.15142332
7RNA transport_Homo sapiens_hsa030132.89590528
8Homologous recombination_Homo sapiens_hsa034402.89370174
9RNA polymerase_Homo sapiens_hsa030202.83509138
10Nucleotide excision repair_Homo sapiens_hsa034202.77920623
11One carbon pool by folate_Homo sapiens_hsa006702.70436885
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66633245
13Proteasome_Homo sapiens_hsa030502.57489039
14Cell cycle_Homo sapiens_hsa041102.56769374
15Pyrimidine metabolism_Homo sapiens_hsa002402.41167958
16Fanconi anemia pathway_Homo sapiens_hsa034602.19268151
17Protein export_Homo sapiens_hsa030602.11087574
18Non-homologous end-joining_Homo sapiens_hsa034501.91561022
19Propanoate metabolism_Homo sapiens_hsa006401.84009548
20RNA degradation_Homo sapiens_hsa030181.76524722
21p53 signaling pathway_Homo sapiens_hsa041151.74087274
22mRNA surveillance pathway_Homo sapiens_hsa030151.49840677
23Basal transcription factors_Homo sapiens_hsa030221.49609162
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35787751
25Pyruvate metabolism_Homo sapiens_hsa006201.29786737
26Systemic lupus erythematosus_Homo sapiens_hsa053221.26702500
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25475292
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23065135
29Purine metabolism_Homo sapiens_hsa002301.18754990
30Epstein-Barr virus infection_Homo sapiens_hsa051691.15638046
31Parkinsons disease_Homo sapiens_hsa050121.15315250
32Antigen processing and presentation_Homo sapiens_hsa046121.09816011
33Viral carcinogenesis_Homo sapiens_hsa052031.08972514
34Herpes simplex infection_Homo sapiens_hsa051681.04265611
35Huntingtons disease_Homo sapiens_hsa050161.00123840
36Oxidative phosphorylation_Homo sapiens_hsa001900.99721967
37Primary immunodeficiency_Homo sapiens_hsa053400.94212269
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92164722
39Thyroid cancer_Homo sapiens_hsa052160.89294435
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88587451
41HTLV-I infection_Homo sapiens_hsa051660.88047343
42Steroid biosynthesis_Homo sapiens_hsa001000.88008675
43Oocyte meiosis_Homo sapiens_hsa041140.87971880
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86941677
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83902531
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81990779
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.81440988
48Selenocompound metabolism_Homo sapiens_hsa004500.80317797
49Pentose phosphate pathway_Homo sapiens_hsa000300.75617211
50Fatty acid elongation_Homo sapiens_hsa000620.75011875
51Biosynthesis of amino acids_Homo sapiens_hsa012300.74947209
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74677872
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.70174822
54Shigellosis_Homo sapiens_hsa051310.69942637
55N-Glycan biosynthesis_Homo sapiens_hsa005100.69175910
56MicroRNAs in cancer_Homo sapiens_hsa052060.68764359
57Folate biosynthesis_Homo sapiens_hsa007900.67676002
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66403880
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64993920
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64982358
61Measles_Homo sapiens_hsa051620.63930932
62Sulfur relay system_Homo sapiens_hsa041220.60292189
63Acute myeloid leukemia_Homo sapiens_hsa052210.59723478
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59552044
65Hepatitis B_Homo sapiens_hsa051610.59193407
66Lysine degradation_Homo sapiens_hsa003100.57854658
67Small cell lung cancer_Homo sapiens_hsa052220.57183312
68Alzheimers disease_Homo sapiens_hsa050100.56869657
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.56347846
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53797921
71Chronic myeloid leukemia_Homo sapiens_hsa052200.53746222
72Notch signaling pathway_Homo sapiens_hsa043300.53020392
73Apoptosis_Homo sapiens_hsa042100.52739328
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.50855626
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49375235
76Colorectal cancer_Homo sapiens_hsa052100.49355005
77Alcoholism_Homo sapiens_hsa050340.48721306
78Legionellosis_Homo sapiens_hsa051340.48531336
79Glutathione metabolism_Homo sapiens_hsa004800.46139174
80Non-small cell lung cancer_Homo sapiens_hsa052230.45613967
81Metabolic pathways_Homo sapiens_hsa011000.45496217
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.44218284
83B cell receptor signaling pathway_Homo sapiens_hsa046620.43834431
84Hematopoietic cell lineage_Homo sapiens_hsa046400.43813082
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43416683
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43157756
87Vitamin B6 metabolism_Homo sapiens_hsa007500.41021946
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39496822
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39176885
90mTOR signaling pathway_Homo sapiens_hsa041500.36807730
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36056711
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34720271
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34180074
94Pathways in cancer_Homo sapiens_hsa052000.33759132
95Fatty acid metabolism_Homo sapiens_hsa012120.32916026
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32680979
97HIF-1 signaling pathway_Homo sapiens_hsa040660.31044646
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30796389
99Carbon metabolism_Homo sapiens_hsa012000.30021421
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28861212
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.28318603
102Influenza A_Homo sapiens_hsa051640.28106569
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28008822
104Bladder cancer_Homo sapiens_hsa052190.27591872
105TGF-beta signaling pathway_Homo sapiens_hsa043500.27510002
106Peroxisome_Homo sapiens_hsa041460.27085533
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26751974
108Galactose metabolism_Homo sapiens_hsa000520.25777718
109Renin-angiotensin system_Homo sapiens_hsa046140.25091164
110Viral myocarditis_Homo sapiens_hsa054160.24687260
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24167218
112Leishmaniasis_Homo sapiens_hsa051400.23354025
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23212686
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23092425
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.22509670
116Platelet activation_Homo sapiens_hsa046110.22420404
117Hippo signaling pathway_Homo sapiens_hsa043900.21565043
118T cell receptor signaling pathway_Homo sapiens_hsa046600.20383099
119Other glycan degradation_Homo sapiens_hsa005110.19662141
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.19022703
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18734950
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18501034
123Arginine and proline metabolism_Homo sapiens_hsa003300.18498633
124Basal cell carcinoma_Homo sapiens_hsa052170.18162622
125Fructose and mannose metabolism_Homo sapiens_hsa000510.18106955
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17696741
127beta-Alanine metabolism_Homo sapiens_hsa004100.16759534
128Wnt signaling pathway_Homo sapiens_hsa043100.15067521
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13126388
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10538553
131Sulfur metabolism_Homo sapiens_hsa009200.07204548
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06950674
133Fatty acid biosynthesis_Homo sapiens_hsa000610.04579514
134Adherens junction_Homo sapiens_hsa045200.03282601
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03225167
136Pancreatic cancer_Homo sapiens_hsa052120.02695772
137Prostate cancer_Homo sapiens_hsa05215-0.0325872

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