PRLHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transmission of nerve impulse (GO:0051969)9.46926522
2positive regulation of neurological system process (GO:0031646)7.34284371
3behavioral response to nicotine (GO:0035095)5.33021991
4locomotory exploration behavior (GO:0035641)5.29798363
5axon ensheathment in central nervous system (GO:0032291)5.03776974
6central nervous system myelination (GO:0022010)5.03776974
7negative regulation of neurological system process (GO:0031645)4.95206640
8synaptic vesicle maturation (GO:0016188)4.93242418
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72646427
10virion attachment to host cell (GO:0019062)4.67736546
11adhesion of symbiont to host cell (GO:0044650)4.67736546
12neuron cell-cell adhesion (GO:0007158)4.52517245
13regulation of collateral sprouting (GO:0048670)4.21918354
14negative regulation of potassium ion transport (GO:0043267)4.06006660
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93266415
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.90326576
17regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86571621
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76165637
19DNA deamination (GO:0045006)3.73113169
20vocalization behavior (GO:0071625)3.63880846
21negative regulation of axon guidance (GO:1902668)3.61678980
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56123184
23L-fucose catabolic process (GO:0042355)3.55036995
24fucose catabolic process (GO:0019317)3.55036995
25L-fucose metabolic process (GO:0042354)3.55036995
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53342485
27exploration behavior (GO:0035640)3.52604030
28neurotransmitter secretion (GO:0007269)3.52366197
29adhesion of symbiont to host (GO:0044406)3.52137333
30nonmotile primary cilium assembly (GO:0035058)3.51414144
31gamma-aminobutyric acid transport (GO:0015812)3.51249513
32negative regulation of axon extension (GO:0030517)3.48854800
33dendritic spine morphogenesis (GO:0060997)3.48493588
34synaptic vesicle exocytosis (GO:0016079)3.48078745
35adult walking behavior (GO:0007628)3.47654541
36regulation of postsynaptic membrane potential (GO:0060078)3.47219872
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.45527799
38negative regulation of telomere maintenance (GO:0032205)3.42470177
39L-amino acid import (GO:0043092)3.39694788
40response to pheromone (GO:0019236)3.32189450
41postsynaptic membrane organization (GO:0001941)3.30865840
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30683908
43amino acid import (GO:0043090)3.29866534
44piRNA metabolic process (GO:0034587)3.29832155
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.27939319
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26412631
47protein-cofactor linkage (GO:0018065)3.25284240
48indolalkylamine catabolic process (GO:0046218)3.24668714
49tryptophan catabolic process (GO:0006569)3.24668714
50indole-containing compound catabolic process (GO:0042436)3.24668714
51mating behavior (GO:0007617)3.24154248
52glutamate secretion (GO:0014047)3.23798759
53glycerophospholipid catabolic process (GO:0046475)3.21766473
54positive regulation of cardiac muscle cell differentiation (GO:2000727)3.20979855
55neuromuscular process controlling balance (GO:0050885)3.19077598
56axoneme assembly (GO:0035082)3.18574579
57respiratory chain complex IV assembly (GO:0008535)3.16990508
58epithelial cilium movement (GO:0003351)3.16575379
59dendrite morphogenesis (GO:0048813)3.16382040
60negative regulation of axonogenesis (GO:0050771)3.15296372
61neurotransmitter transport (GO:0006836)3.14974254
62neuronal action potential (GO:0019228)3.14696517
63neuronal action potential propagation (GO:0019227)3.14565328
64detection of light stimulus involved in sensory perception (GO:0050962)3.14102733
65detection of light stimulus involved in visual perception (GO:0050908)3.14102733
66regulation of neurotransmitter secretion (GO:0046928)3.12903643
67layer formation in cerebral cortex (GO:0021819)3.12468278
68ensheathment of neurons (GO:0007272)3.11911268
69axon ensheathment (GO:0008366)3.11911268
70neuron recognition (GO:0008038)3.10895342
71protein complex biogenesis (GO:0070271)3.10505124
72kidney morphogenesis (GO:0060993)3.10504264
73presynaptic membrane assembly (GO:0097105)3.10459139
74retinal cone cell development (GO:0046549)3.09924836
75transmission of nerve impulse (GO:0019226)3.08821145
76presynaptic membrane organization (GO:0097090)3.08485787
77membrane depolarization (GO:0051899)3.07859209
78neuroblast proliferation (GO:0007405)3.07296567
79regulation of glutamate secretion (GO:0014048)3.07229878
80protein localization to synapse (GO:0035418)3.06691420
81ubiquinone biosynthetic process (GO:0006744)3.06457799
82regulation of glutamate receptor signaling pathway (GO:1900449)3.06368047
83neuromuscular process controlling posture (GO:0050884)3.06093513
84myelination (GO:0042552)3.05272355
85water-soluble vitamin biosynthetic process (GO:0042364)3.05108759
86kynurenine metabolic process (GO:0070189)3.03752616
87indolalkylamine metabolic process (GO:0006586)3.03639190
88glutamate receptor signaling pathway (GO:0007215)3.02840570
89cellular ketone body metabolic process (GO:0046950)3.02101126
90platelet dense granule organization (GO:0060155)3.01552494
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01420831
92pyrimidine nucleobase catabolic process (GO:0006208)2.99994277
93protein polyglutamylation (GO:0018095)2.99727174
94regulation of neurotransmitter transport (GO:0051588)2.99433573
95regulation of axon guidance (GO:1902667)2.98269926
96regulation of potassium ion transport (GO:0043266)2.98172233
97positive regulation of gastrulation (GO:2000543)2.96726282
98regulation of neurotransmitter levels (GO:0001505)2.96293166
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95914636
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93419602
101regulation of protein kinase A signaling (GO:0010738)2.92543285
102regulation of vesicle fusion (GO:0031338)2.91737924
103apical protein localization (GO:0045176)2.91565002
104cornea development in camera-type eye (GO:0061303)2.91196307
105ubiquinone metabolic process (GO:0006743)2.90677096
106cerebellar granule cell differentiation (GO:0021707)2.90302057
107auditory behavior (GO:0031223)2.89657501
108axonal fasciculation (GO:0007413)2.89248291
109negative regulation of transcription regulatory region DNA binding (GO:2000678)2.88904166
110nephron epithelium morphogenesis (GO:0072088)2.88538275
111nephron tubule morphogenesis (GO:0072078)2.88538275
112negative regulation of mast cell activation (GO:0033004)2.88484004
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.88306672
114regulation of neuronal synaptic plasticity (GO:0048168)2.87795633
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86611329
116primary amino compound metabolic process (GO:1901160)2.84554776
117gamma-aminobutyric acid signaling pathway (GO:0007214)2.82711047
118neuronal ion channel clustering (GO:0045161)2.82608497
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.81731987
120NADH dehydrogenase complex assembly (GO:0010257)2.81731987
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81731987
122mitochondrial respiratory chain complex assembly (GO:0033108)2.81073738
123synaptic transmission, glutamatergic (GO:0035249)2.80237917
124regulation of axon extension involved in axon guidance (GO:0048841)2.80124677
125positive regulation of protein tyrosine kinase activity (GO:0061098)2.79896799
126cerebellar Purkinje cell differentiation (GO:0021702)2.79774013
127neuron-neuron synaptic transmission (GO:0007270)2.79281287
128serotonin metabolic process (GO:0042428)2.79250620
129regulation of action potential (GO:0098900)2.78690217
130positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78623788
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78518797
132neurotransmitter uptake (GO:0001504)2.78491588
133cytochrome complex assembly (GO:0017004)2.78096049
134ketone body metabolic process (GO:1902224)2.78032501
135nucleobase catabolic process (GO:0046113)2.77940381
136neuromuscular junction development (GO:0007528)2.77820512
137indole-containing compound metabolic process (GO:0042430)2.77407485
138regulation of synaptic vesicle exocytosis (GO:2000300)2.76770014
139behavioral response to ethanol (GO:0048149)2.76612857
140regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76425229
141eating behavior (GO:0042755)2.75963516
142regulation of neurotransmitter uptake (GO:0051580)2.75698203
143positive regulation of meiosis (GO:0045836)2.75596377
144peripheral nervous system development (GO:0007422)2.74664812
145striatum development (GO:0021756)2.74433471
146long-term memory (GO:0007616)2.73536731
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71176893
148substantia nigra development (GO:0021762)2.70985550
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.70848636
150regulation of synaptic vesicle transport (GO:1902803)2.70680880
151synapse organization (GO:0050808)2.70391184
152glycine transport (GO:0015816)2.69730315
153cerebellar Purkinje cell layer development (GO:0021680)2.69608372
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68862140
155activation of protein kinase A activity (GO:0034199)2.68824217
156cilium movement (GO:0003341)2.67701782
157startle response (GO:0001964)2.67325154
158cilium organization (GO:0044782)2.67161431
159regulation of meiosis I (GO:0060631)2.66773042
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66379181
161cellular potassium ion homeostasis (GO:0030007)2.64879026
162tryptophan metabolic process (GO:0006568)2.63067615
163cilium assembly (GO:0042384)2.59960085
164regulation of cilium movement (GO:0003352)2.59766558
165reflex (GO:0060004)2.59478438
166synaptic transmission, cholinergic (GO:0007271)2.59472938
167somite development (GO:0061053)2.55662858
168preassembly of GPI anchor in ER membrane (GO:0016254)2.55615602
169sulfation (GO:0051923)2.54873070
170positive regulation of meiotic cell cycle (GO:0051446)2.54855363
171photoreceptor cell maintenance (GO:0045494)2.54784223
172neuron fate determination (GO:0048664)2.52827397
173cilium morphogenesis (GO:0060271)2.52537339
174photoreceptor cell development (GO:0042461)2.51548316
175quinone biosynthetic process (GO:1901663)2.49997393
176retinal ganglion cell axon guidance (GO:0031290)2.49543720
177mannosylation (GO:0097502)2.49126804
178spinal cord motor neuron differentiation (GO:0021522)2.48550672
179S-adenosylmethionine metabolic process (GO:0046500)2.48212080
180DNA methylation involved in gamete generation (GO:0043046)2.47400374
181regulation of hexokinase activity (GO:1903299)2.43826982
182regulation of glucokinase activity (GO:0033131)2.43826982
183action potential (GO:0001508)2.41908289
184cellular biogenic amine catabolic process (GO:0042402)2.41641352
185amine catabolic process (GO:0009310)2.41641352
186multicellular organism reproduction (GO:0032504)2.41241246
187membrane depolarization during action potential (GO:0086010)2.39087356
188cAMP catabolic process (GO:0006198)2.38274296
189tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37871546
190RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37871546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98488275
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.35975420
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10525463
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08884757
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91310779
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91310779
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.87605179
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.70721962
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66836859
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63401062
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60471844
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59300553
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59274478
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57577535
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.56628561
16IGF1R_20145208_ChIP-Seq_DFB_Human2.52536449
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47627718
18DROSHA_22980978_ChIP-Seq_HELA_Human2.46448749
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40961200
20GBX2_23144817_ChIP-Seq_PC3_Human2.31256505
21REST_21632747_ChIP-Seq_MESCs_Mouse2.26973171
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15864229
23ZNF274_21170338_ChIP-Seq_K562_Hela2.15003780
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.13411942
25FUS_26573619_Chip-Seq_HEK293_Human2.05506274
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03237921
27AR_21572438_ChIP-Seq_LNCaP_Human2.02508520
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96990060
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.95746972
30EWS_26573619_Chip-Seq_HEK293_Human1.95109609
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.94081777
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.89841545
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.87546913
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85364902
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76631435
36ER_23166858_ChIP-Seq_MCF-7_Human1.72952136
37BCAT_22108803_ChIP-Seq_LS180_Human1.67317990
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66377845
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60320161
40* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57984218
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56318792
42* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52249415
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51683614
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.50745188
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49999937
46CBP_20019798_ChIP-Seq_JUKART_Human1.49999937
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49095631
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48961498
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.48679093
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.48533560
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47949715
52TAF15_26573619_Chip-Seq_HEK293_Human1.47611032
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47372557
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47081665
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45533086
56TP53_22573176_ChIP-Seq_HFKS_Human1.42867743
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42495355
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.39401045
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37850155
60SOX2_19829295_ChIP-Seq_ESCs_Human1.36140005
61NANOG_19829295_ChIP-Seq_ESCs_Human1.36140005
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34134135
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33634167
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31849294
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31072208
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29280776
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28165634
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27990550
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27360084
70MYC_18940864_ChIP-ChIP_HL60_Human1.26995107
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.26152549
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.25377370
73RUNX2_22187159_ChIP-Seq_PCA_Human1.24698256
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23838149
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.22957902
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.22037677
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21666754
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.21146730
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20838018
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.19879248
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.19032256
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19032256
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19013538
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.18541280
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17203974
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.17010996
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16539808
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16476308
89IRF1_19129219_ChIP-ChIP_H3396_Human1.15189882
90P300_19829295_ChIP-Seq_ESCs_Human1.14949256
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.14647720
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.13406032
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13236058
94AHR_22903824_ChIP-Seq_MCF-7_Human1.13107841
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12691821
96NCOR_22424771_ChIP-Seq_293T_Human1.11904877
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11716426
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10975763
99* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10672403
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09184650
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.09069542
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09044558
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.08726665
104* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08046269
105AR_20517297_ChIP-Seq_VCAP_Human1.07824245
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07566403
107P53_22387025_ChIP-Seq_ESCs_Mouse1.07465438
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06534401
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.06298481
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05785750
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.04889539
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.04690759
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03867415
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.03798324
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03611897
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01387612
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01116298
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00286632
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99754651
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99461784
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.99150237
122KDM2B_26808549_Chip-Seq_K562_Human0.98948805
123* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98808975
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98731094
125* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98325476
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98174758
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98045080
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97951025
129* CTCF_27219007_Chip-Seq_Bcells_Human0.97790236
130AR_19668381_ChIP-Seq_PC3_Human0.97417384
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96617139
132RNF2_27304074_Chip-Seq_NSC_Mouse0.94296897
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.89978388
134TCF4_23295773_ChIP-Seq_U87_Human0.89318508
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89197092
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.89078346
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87451372
138VDR_22108803_ChIP-Seq_LS180_Human0.87188017
139STAT3_23295773_ChIP-Seq_U87_Human0.86632929
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86190157
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84236902
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83618529
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83399480
144* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81241459
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.80903684
146AR_25329375_ChIP-Seq_VCAP_Human0.80714558
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80496430
148TCF4_22108803_ChIP-Seq_LS180_Human0.80380341
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78767936
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78130191
151ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77795037
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76910873
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76652681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.21879720
2MP0004270_analgesia3.76457859
3MP0003880_abnormal_central_pattern3.60989648
4MP0000569_abnormal_digit_pigmentation3.23229843
5MP0003635_abnormal_synaptic_transmissio3.22478331
6MP0008877_abnormal_DNA_methylation2.97512315
7MP0002272_abnormal_nervous_system2.97048355
8* MP0009745_abnormal_behavioral_response2.94180133
9MP0003136_yellow_coat_color2.85569331
10MP0005645_abnormal_hypothalamus_physiol2.84802550
11MP0002064_seizures2.78255650
12MP0005423_abnormal_somatic_nervous2.74073339
13* MP0002734_abnormal_mechanical_nocicepti2.44278177
14MP0009046_muscle_twitch2.42955118
15MP0000920_abnormal_myelination2.38921013
16MP0001529_abnormal_vocalization2.32336883
17MP0001486_abnormal_startle_reflex2.29196378
18MP0003183_abnormal_peptide_metabolism2.25891544
19MP0004885_abnormal_endolymph2.22893921
20MP0004742_abnormal_vestibular_system2.20316430
21* MP0002063_abnormal_learning/memory/cond2.20237169
22MP0005257_abnormal_intraocular_pressure2.16406791
23MP0002572_abnormal_emotion/affect_behav2.15954623
24MP0001905_abnormal_dopamine_level2.13202509
25MP0002837_dystrophic_cardiac_calcinosis2.11993346
26MP0006292_abnormal_olfactory_placode2.11890261
27MP0002638_abnormal_pupillary_reflex2.08062731
28MP0003195_calcinosis2.07301595
29MP0001440_abnormal_grooming_behavior2.04485191
30MP0002909_abnormal_adrenal_gland2.02401829
31MP0002822_catalepsy2.01639327
32* MP0001970_abnormal_pain_threshold2.00613019
33MP0001501_abnormal_sleep_pattern1.95633640
34MP0000013_abnormal_adipose_tissue1.91470133
35MP0005171_absent_coat_pigmentation1.86587954
36MP0008569_lethality_at_weaning1.85046848
37* MP0002733_abnormal_thermal_nociception1.81500101
38MP0004133_heterotaxia1.73187030
39MP0004924_abnormal_behavior1.72027532
40MP0005386_behavior/neurological_phenoty1.72027532
41MP0002735_abnormal_chemical_nociception1.72001141
42MP0005253_abnormal_eye_physiology1.66114060
43MP0001986_abnormal_taste_sensitivity1.65435273
44MP0002067_abnormal_sensory_capabilities1.64824635
45MP0000751_myopathy1.64502279
46MP0000778_abnormal_nervous_system1.62416865
47MP0001968_abnormal_touch/_nociception1.59355817
48MP0006276_abnormal_autonomic_nervous1.55352141
49MP0008872_abnormal_physiological_respon1.54576002
50MP0001348_abnormal_lacrimal_gland1.54562094
51MP0000427_abnormal_hair_cycle1.50241085
52MP0008875_abnormal_xenobiotic_pharmacok1.49377124
53MP0004142_abnormal_muscle_tone1.47822203
54MP0004147_increased_porphyrin_level1.44974084
55MP0010386_abnormal_urinary_bladder1.44323525
56MP0002066_abnormal_motor_capabilities/c1.40263011
57MP0003122_maternal_imprinting1.39147434
58MP0005174_abnormal_tail_pigmentation1.37862721
59MP0003011_delayed_dark_adaptation1.37548416
60MP0002184_abnormal_innervation1.35436618
61MP0003329_amyloid_beta_deposits1.33399422
62MP0008995_early_reproductive_senescence1.32019247
63MP0001299_abnormal_eye_distance/1.30010533
64MP0004085_abnormal_heartbeat1.30003821
65MP0002557_abnormal_social/conspecific_i1.29888197
66MP0000955_abnormal_spinal_cord1.29721305
67MP0002882_abnormal_neuron_morphology1.29646215
68MP0003718_maternal_effect1.29234253
69MP0003634_abnormal_glial_cell1.28430628
70MP0003632_abnormal_nervous_system1.27750715
71MP0005084_abnormal_gallbladder_morpholo1.26820551
72MP0000639_abnormal_adrenal_gland1.26707163
73MP0002751_abnormal_autonomic_nervous1.24491132
74MP0003172_abnormal_lysosome_physiology1.24276278
75MP0002277_abnormal_respiratory_mucosa1.22916691
76MP0003631_nervous_system_phenotype1.20198692
77MP0002102_abnormal_ear_morphology1.18912780
78MP0005535_abnormal_body_temperature1.15475068
79MP0002160_abnormal_reproductive_system1.15193912
80MP0003633_abnormal_nervous_system1.13838127
81MP0004145_abnormal_muscle_electrophysio1.13230924
82MP0002229_neurodegeneration1.12231376
83MP0003690_abnormal_glial_cell1.07331567
84MP0005551_abnormal_eye_electrophysiolog1.07047172
85MP0002163_abnormal_gland_morphology1.06951758
86MP0000372_irregular_coat_pigmentation1.06601932
87MP0001485_abnormal_pinna_reflex1.06034589
88MP0000631_abnormal_neuroendocrine_gland1.06028056
89MP0003646_muscle_fatigue1.05130339
90MP0000647_abnormal_sebaceous_gland1.04184760
91MP0008789_abnormal_olfactory_epithelium1.03823396
92MP0005389_reproductive_system_phenotype1.01054741
93MP0002928_abnormal_bile_duct1.00791556
94MP0003283_abnormal_digestive_organ1.00679963
95MP0003123_paternal_imprinting1.00138026
96MP0004811_abnormal_neuron_physiology0.99904780
97MP0002095_abnormal_skin_pigmentation0.99137249
98MP0000026_abnormal_inner_ear0.98122735
99MP0003890_abnormal_embryonic-extraembry0.97269240
100MP0002090_abnormal_vision0.96291840
101MP0004858_abnormal_nervous_system0.95209295
102MP0005195_abnormal_posterior_eye0.95161833
103MP0001963_abnormal_hearing_physiology0.94938046
104MP0000230_abnormal_systemic_arterial0.94094239
105MP0005379_endocrine/exocrine_gland_phen0.94072912
106MP0000747_muscle_weakness0.92094344
107MP0000003_abnormal_adipose_tissue0.90667522
108MP0002152_abnormal_brain_morphology0.89375428
109MP0005187_abnormal_penis_morphology0.88227035
110MP0005409_darkened_coat_color0.87666104
111MP0009780_abnormal_chondrocyte_physiolo0.87200558
112MP0001944_abnormal_pancreas_morphology0.85880869
113MP0001293_anophthalmia0.85498746
114MP0003787_abnormal_imprinting0.85149017
115MP0003698_abnormal_male_reproductive0.85067202
116MP0002138_abnormal_hepatobiliary_system0.84553118
117MP0001929_abnormal_gametogenesis0.83925036
118MP0002210_abnormal_sex_determination0.83678206
119MP0005646_abnormal_pituitary_gland0.83047377
120MP0005083_abnormal_biliary_tract0.82762716
121MP0006072_abnormal_retinal_apoptosis0.82537385
122MP0003119_abnormal_digestive_system0.81275694
123MP0003137_abnormal_impulse_conducting0.81104403
124MP0003121_genomic_imprinting0.80669998
125MP0004043_abnormal_pH_regulation0.78783854
126MP0002736_abnormal_nociception_after0.78734466
127MP0002938_white_spotting0.77278901
128MP0001346_abnormal_lacrimal_gland0.76318354
129MP0001502_abnormal_circadian_rhythm0.75897559
130MP0001984_abnormal_olfaction0.74222102
131MP0008058_abnormal_DNA_repair0.73910951
132MP0001188_hyperpigmentation0.73061746
133MP0002752_abnormal_somatic_nervous0.71813683
134* MP0002069_abnormal_eating/drinking_beha0.70819333
135MP0003938_abnormal_ear_development0.67493052
136MP0001943_abnormal_respiration0.64032655
137MP0002653_abnormal_ependyma_morphology0.63472490
138MP0002876_abnormal_thyroid_physiology0.63288808
139MP0002234_abnormal_pharynx_morphology0.62645619

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.89759982
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.27017206
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.27017206
4Abnormality of the corticospinal tract (HP:0002492)5.19927945
5Ankle clonus (HP:0011448)4.67912030
6Neurofibrillary tangles (HP:0002185)4.65051760
7Pancreatic cysts (HP:0001737)4.39084284
8Pancreatic fibrosis (HP:0100732)4.27710616
9True hermaphroditism (HP:0010459)3.96929003
10Focal seizures (HP:0007359)3.92642211
11Supranuclear gaze palsy (HP:0000605)3.87925423
12Peripheral hypomyelination (HP:0007182)3.86753396
13Cerebral inclusion bodies (HP:0100314)3.79923961
14Abnormality of midbrain morphology (HP:0002418)3.77243874
15Molar tooth sign on MRI (HP:0002419)3.77243874
16Spastic gait (HP:0002064)3.77034882
17Papilledema (HP:0001085)3.69827395
18Atonic seizures (HP:0010819)3.46655220
19Congenital stationary night blindness (HP:0007642)3.46488914
20Alacrima (HP:0000522)3.42302337
21Dialeptic seizures (HP:0011146)3.40360531
22Nephronophthisis (HP:0000090)3.32243616
23Focal motor seizures (HP:0011153)3.27747213
24Parakeratosis (HP:0001036)3.27354692
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.23970510
26Hemiparesis (HP:0001269)3.23414360
27Dysmetria (HP:0001310)3.19301812
28Visual hallucinations (HP:0002367)3.16392806
29Type II lissencephaly (HP:0007260)3.16184580
30Delayed CNS myelination (HP:0002188)3.10244979
31Medial flaring of the eyebrow (HP:0010747)3.03923703
32Action tremor (HP:0002345)3.01030864
33Epileptic encephalopathy (HP:0200134)2.98448462
34Impaired vibration sensation in the lower limbs (HP:0002166)2.95928677
35Anxiety (HP:0000739)2.93090187
36Intestinal atresia (HP:0011100)2.92022168
37Broad-based gait (HP:0002136)2.91911660
38Generalized tonic-clonic seizures (HP:0002069)2.85817772
39Abnormality of the renal cortex (HP:0011035)2.84237476
40Abnormality of the renal medulla (HP:0100957)2.83274137
41Morphological abnormality of the pyramidal tract (HP:0002062)2.81882826
42Optic nerve hypoplasia (HP:0000609)2.77531873
43Pendular nystagmus (HP:0012043)2.75302575
44Decreased lacrimation (HP:0000633)2.70772619
45Absence seizures (HP:0002121)2.70321421
46Cystic liver disease (HP:0006706)2.70117862
47Mutism (HP:0002300)2.69066915
48Urinary urgency (HP:0000012)2.68332233
49Acute necrotizing encephalopathy (HP:0006965)2.67842433
50Hyperventilation (HP:0002883)2.67444669
51Limb dystonia (HP:0002451)2.67212739
52Abnormality of the labia minora (HP:0012880)2.65525681
53Large for gestational age (HP:0001520)2.64696406
54Torticollis (HP:0000473)2.64165432
55Tubular atrophy (HP:0000092)2.61029240
56Sensory axonal neuropathy (HP:0003390)2.58404928
57Morphological abnormality of the inner ear (HP:0011390)2.58107605
58Lower limb muscle weakness (HP:0007340)2.57695048
59Agitation (HP:0000713)2.57564153
60Attenuation of retinal blood vessels (HP:0007843)2.56957749
61Scanning speech (HP:0002168)2.54188378
62Chronic hepatic failure (HP:0100626)2.50594356
63Abnormal rod and cone electroretinograms (HP:0008323)2.49205289
64Gait imbalance (HP:0002141)2.49197869
65Spastic tetraplegia (HP:0002510)2.48958411
66Progressive cerebellar ataxia (HP:0002073)2.47196428
67Progressive macrocephaly (HP:0004481)2.45892758
68Sclerocornea (HP:0000647)2.45284832
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44795145
70Inability to walk (HP:0002540)2.42601957
71Acute encephalopathy (HP:0006846)2.40705292
72Spastic tetraparesis (HP:0001285)2.38523038
73Lissencephaly (HP:0001339)2.38498257
74Congenital primary aphakia (HP:0007707)2.37739157
75Cerebral hypomyelination (HP:0006808)2.36546252
76Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36526005
77Urinary bladder sphincter dysfunction (HP:0002839)2.35633288
78Intention tremor (HP:0002080)2.32507110
79Polydipsia (HP:0001959)2.30109514
80Abnormal drinking behavior (HP:0030082)2.30109514
81Restlessness (HP:0000711)2.29956018
82Mitochondrial inheritance (HP:0001427)2.28726290
83Focal dystonia (HP:0004373)2.27451694
84Clonus (HP:0002169)2.26089217
85Congenital, generalized hypertrichosis (HP:0004540)2.25863826
86Keratoconus (HP:0000563)2.24776584
87Increased corneal curvature (HP:0100692)2.24776584
88Supernumerary spleens (HP:0009799)2.24549954
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.24274995
90Absent/shortened dynein arms (HP:0200106)2.24274995
91Optic disc pallor (HP:0000543)2.24106680
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.23081129
93Abnormal respiratory epithelium morphology (HP:0012253)2.22533113
94Abnormal respiratory motile cilium morphology (HP:0005938)2.22533113
95Craniofacial dystonia (HP:0012179)2.22390239
96Abnormal auditory evoked potentials (HP:0006958)2.21940672
97Anosmia (HP:0000458)2.20769443
98Progressive inability to walk (HP:0002505)2.19425016
99Increased CSF lactate (HP:0002490)2.19351437
100Dysdiadochokinesis (HP:0002075)2.19118160
101Abnormal mitochondria in muscle tissue (HP:0008316)2.18960975
102Abnormal ciliary motility (HP:0012262)2.17593849
103Nephrogenic diabetes insipidus (HP:0009806)2.17569791
104Anencephaly (HP:0002323)2.17014888
105Memory impairment (HP:0002354)2.15988723
106Neoplasm of the heart (HP:0100544)2.14036374
107Onion bulb formation (HP:0003383)2.12728780
108Microglossia (HP:0000171)2.12636055
109Gastrointestinal atresia (HP:0002589)2.12589905
110Hypothermia (HP:0002045)2.12221391
111Abolished electroretinogram (ERG) (HP:0000550)2.11528613
112Genital tract atresia (HP:0001827)2.09849343
113Depression (HP:0000716)2.08643747
114Bile duct proliferation (HP:0001408)2.08565042
115Abnormal biliary tract physiology (HP:0012439)2.08565042
116Neuronal loss in central nervous system (HP:0002529)2.08557366
117Increased cerebral lipofuscin (HP:0011813)2.07117025
118Male pseudohermaphroditism (HP:0000037)2.07049515
119Furrowed tongue (HP:0000221)2.06915101
120Renal cortical cysts (HP:0000803)2.06218712
121Abnormal autonomic nervous system physiology (HP:0012332)2.05269099
122Fair hair (HP:0002286)2.04534498
123Amyotrophic lateral sclerosis (HP:0007354)2.04308710
124Aplasia/Hypoplasia of the tibia (HP:0005772)2.04298897
125Congenital hepatic fibrosis (HP:0002612)2.03480433
126Oligodactyly (hands) (HP:0001180)2.01960520
127Mixed hearing impairment (HP:0000410)2.01534590
128Hypoplasia of the fovea (HP:0007750)2.01447479
129Aplasia/Hypoplasia of the fovea (HP:0008060)2.01447479
130Hemiplegia (HP:0002301)1.99758595
131Delayed myelination (HP:0012448)1.99428416
132Ketoacidosis (HP:0001993)1.98583154
133Poor suck (HP:0002033)1.97431275
134Abnormality of the fovea (HP:0000493)1.97216455
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96720639
136Abnormality of alanine metabolism (HP:0010916)1.96720639
137Hyperalaninemia (HP:0003348)1.96720639
138Excessive salivation (HP:0003781)1.96177241
139Drooling (HP:0002307)1.96177241
140Abnormality of the pons (HP:0007361)1.95904493
141Diplopia (HP:0000651)1.95864402
142Abnormality of binocular vision (HP:0011514)1.95864402
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.95620429
144Adrenal hypoplasia (HP:0000835)1.95535408
145Retinal dysplasia (HP:0007973)1.95269008
146Vaginal atresia (HP:0000148)1.95268663
147Pachygyria (HP:0001302)1.93785921
148Choreoathetosis (HP:0001266)1.92411509
149Cerebellar dysplasia (HP:0007033)1.92335942
150Concave nail (HP:0001598)1.92161207
151Postaxial foot polydactyly (HP:0001830)1.91783149
152Gaze-evoked nystagmus (HP:0000640)1.90650222
153Hypoplasia of the pons (HP:0012110)1.90494028
154Poor speech (HP:0002465)1.90384490
155Psychosis (HP:0000709)1.89766881
156Hypomagnesemia (HP:0002917)1.89393851
157Genetic anticipation (HP:0003743)1.89133750
158White forelock (HP:0002211)1.89069825
159Muscular hypotonia of the trunk (HP:0008936)1.87565792
160Postaxial hand polydactyly (HP:0001162)1.86774297
161Polyuria (HP:0000103)1.86646824
162Bony spicule pigmentary retinopathy (HP:0007737)1.86510224
163Septo-optic dysplasia (HP:0100842)1.85602336
164Hammertoe (HP:0001765)1.85448230
165Congenital sensorineural hearing impairment (HP:0008527)1.85286914
166Decreased central vision (HP:0007663)1.84512780
167Severe muscular hypotonia (HP:0006829)1.83849168
168Clumsiness (HP:0002312)1.83718880
169Truncal ataxia (HP:0002078)1.83621277
170Infantile muscular hypotonia (HP:0008947)1.83080586
171Amblyopia (HP:0000646)1.83028261
172Abnormality of the periventricular white matter (HP:0002518)1.82627314
173Neuroendocrine neoplasm (HP:0100634)1.79518133
174Anophthalmia (HP:0000528)1.79464311
175Short tibia (HP:0005736)1.77891180
176Methylmalonic acidemia (HP:0002912)1.77646252
177Patellar aplasia (HP:0006443)1.76660173
178Abnormal eating behavior (HP:0100738)1.76194649
179Postural tremor (HP:0002174)1.75675915
1803-Methylglutaconic aciduria (HP:0003535)1.75541120
181Pheochromocytoma (HP:0002666)1.75383709
182EEG with generalized epileptiform discharges (HP:0011198)1.75144849
183Blue irides (HP:0000635)1.74808135
184Abnormal respiratory motile cilium physiology (HP:0012261)1.73993931
185Hepatic necrosis (HP:0002605)1.73288456
186Hypsarrhythmia (HP:0002521)1.72600787
187Hyperparathyroidism (HP:0000843)1.71367470
188Absent speech (HP:0001344)1.70374921
189Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69687183
190Epileptiform EEG discharges (HP:0011182)1.68983351
191Paraplegia (HP:0010550)1.68129457
192Urinary incontinence (HP:0000020)1.66014936
193Rapidly progressive (HP:0003678)1.65784252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.38002037
2MARK14.35106621
3ADRBK23.24078587
4FES3.11599942
5UHMK13.03999025
6NTRK12.86247512
7BMPR1B2.85921839
8EPHA42.81324260
9ZAK2.72565307
10MAP4K22.54632489
11NTRK32.49661120
12GRK12.38831970
13STK392.38659974
14PAK62.22211309
15DAPK22.21771544
16ICK2.18516605
17PINK12.14699577
18NTRK22.14053746
19MAP3K92.07176760
20ACVR1B1.94432757
21TLK11.93543424
22TAOK31.93364815
23OXSR11.91871425
24MINK11.90846943
25LIMK11.80177382
26TRIM281.74723092
27MAP3K41.69984454
28EPHB11.69748521
29PHKG21.67398793
30PHKG11.67398793
31TYRO31.65960977
32WNK41.63460653
33CDK51.61329230
34BCR1.60509252
35NUAK11.58485870
36PRKD31.54966397
37CAMK2B1.49669476
38WNK11.48783707
39PNCK1.45858575
40CASK1.44809880
41MAPK131.43340118
42PRPF4B1.41729796
43CDK191.39971043
44PKN11.39391486
45WNK31.32847012
46MAP2K71.32359183
47FGR1.31267815
48MKNK21.28146636
49CSNK1G31.26718721
50STK38L1.23324514
51MAPKAPK51.21729834
52VRK11.21390046
53CSNK1G21.21187901
54CAMK2D1.12450612
55KSR21.11813607
56CSNK1A1L1.08350800
57PRKCH1.08334162
58LATS21.03265430
59CDK151.02640056
60BCKDK1.01287824
61PIK3CG0.99617744
62CDK140.99573726
63CDK180.97726413
64MUSK0.94866056
65ERBB30.94143875
66MARK20.94018844
67MAP2K60.93921172
68MAP2K40.93077316
69PAK20.93034908
70ADRBK10.90140760
71SGK2230.89628479
72SGK4940.89628479
73TSSK60.89072858
74CDK11A0.89050884
75TIE10.88162919
76PAK30.86711919
77EPHA30.86365337
78FYN0.84692078
79CAMK2G0.83351383
80MST40.83135692
81ROCK20.82228644
82PLK30.81751766
83CAMK2A0.79644351
84PRKCG0.79506726
85GRK50.78035401
86TGFBR10.76630149
87HIPK20.76325259
88ALK0.72365250
89NME10.69691685
90TNIK0.68654684
91PTK2B0.67938991
92MAPK100.66992298
93CSNK1G10.65776298
94ERBB20.64558925
95CLK10.64557111
96PIK3CA0.64196653
97ROCK10.63873152
98CDC42BPA0.63754607
99NEK60.63704640
100FGFR20.63695938
101CAMKK20.63590826
102TXK0.63225233
103RPS6KA50.60153434
104FER0.58921862
105CAMKK10.58818625
106RET0.57870962
107DDR20.57634007
108YES10.57426558
109PRKCI0.56013103
110DYRK30.55441661
111CDK30.54780579
112IRAK10.54340948
113STK110.54254771
114RPS6KA30.53945481
115PDPK10.51974296
116MAPK150.51913245
117SRC0.51561267
118WEE10.51540606
119MAP3K20.51305771
120SIK20.51195215
121MKNK10.51010425
122DYRK20.50343287
123SGK20.49647244
124PRKCE0.49075721
125PLK20.48051861
126NLK0.46458101
127PDK10.46258072
128STK160.45688181
129PRKCQ0.45511842
130PLK10.44983259
131PRKACA0.43770505
132CSNK1E0.43475422
133RIPK40.42197464
134PASK0.41681885
135PRKACG0.40445574
136PRKG10.40210936
137CSNK1A10.39685450
138PRKCB0.39570479
139SGK10.39500737
140IRAK30.38225054
141INSRR0.37666244
142CAMK10.37493400
143TESK20.36364365
144CSNK1D0.35146980
145GSK3A0.35098171
146PRKCZ0.34937766
147PRKCA0.34801223
148LMTK20.34593367
149PLK40.30560428
150STK30.29232394
151DYRK1A0.28560859
152TNK20.28493806
153PRKACB0.27299868

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28423485
2GABAergic synapse_Homo sapiens_hsa047273.10734315
3Nitrogen metabolism_Homo sapiens_hsa009103.07287873
4Synaptic vesicle cycle_Homo sapiens_hsa047212.68945543
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58616886
6Morphine addiction_Homo sapiens_hsa050322.57763169
7Glutamatergic synapse_Homo sapiens_hsa047242.36985091
8Olfactory transduction_Homo sapiens_hsa047402.20927828
9Linoleic acid metabolism_Homo sapiens_hsa005912.20699232
10Circadian entrainment_Homo sapiens_hsa047132.20664741
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18080887
12Caffeine metabolism_Homo sapiens_hsa002322.10127369
13Dopaminergic synapse_Homo sapiens_hsa047282.03903285
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02569140
15Selenocompound metabolism_Homo sapiens_hsa004502.01914887
16Cocaine addiction_Homo sapiens_hsa050302.01341529
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96537842
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86282580
19Cholinergic synapse_Homo sapiens_hsa047251.85298730
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83338567
21Amphetamine addiction_Homo sapiens_hsa050311.79735239
22Insulin secretion_Homo sapiens_hsa049111.76964490
23Serotonergic synapse_Homo sapiens_hsa047261.73995853
24Basal transcription factors_Homo sapiens_hsa030221.64770618
25Salivary secretion_Homo sapiens_hsa049701.64424751
26Gastric acid secretion_Homo sapiens_hsa049711.59481932
27Taste transduction_Homo sapiens_hsa047421.52215449
28Axon guidance_Homo sapiens_hsa043601.52095669
29Long-term potentiation_Homo sapiens_hsa047201.51271864
30Long-term depression_Homo sapiens_hsa047301.51261070
31Renin secretion_Homo sapiens_hsa049241.45161854
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44720659
33RNA polymerase_Homo sapiens_hsa030201.41890948
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41109605
35Propanoate metabolism_Homo sapiens_hsa006401.39933107
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38199202
37Hedgehog signaling pathway_Homo sapiens_hsa043401.37098103
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35788259
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33586241
40Cardiac muscle contraction_Homo sapiens_hsa042601.33413726
41Prion diseases_Homo sapiens_hsa050201.27257628
42Peroxisome_Homo sapiens_hsa041461.25596416
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24479178
44RNA degradation_Homo sapiens_hsa030181.23987422
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14350882
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13115923
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12193144
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12155767
49Ether lipid metabolism_Homo sapiens_hsa005651.11244008
50Gap junction_Homo sapiens_hsa045401.10994838
51Bile secretion_Homo sapiens_hsa049761.10028550
52Homologous recombination_Homo sapiens_hsa034401.08105872
53Fanconi anemia pathway_Homo sapiens_hsa034601.07812374
54Ovarian steroidogenesis_Homo sapiens_hsa049131.07312027
55Melanogenesis_Homo sapiens_hsa049161.07018225
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06777518
57Vibrio cholerae infection_Homo sapiens_hsa051101.04818528
58Oxidative phosphorylation_Homo sapiens_hsa001901.03932478
59Phenylalanine metabolism_Homo sapiens_hsa003601.01360416
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00112459
61Collecting duct acid secretion_Homo sapiens_hsa049661.00074735
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99284043
63Type II diabetes mellitus_Homo sapiens_hsa049300.96940585
64Steroid biosynthesis_Homo sapiens_hsa001000.95615481
65GnRH signaling pathway_Homo sapiens_hsa049120.94309562
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94154968
67Oxytocin signaling pathway_Homo sapiens_hsa049210.94028824
68Phototransduction_Homo sapiens_hsa047440.93524823
69Pancreatic secretion_Homo sapiens_hsa049720.93337596
70Alzheimers disease_Homo sapiens_hsa050100.92364400
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91755996
72Arginine biosynthesis_Homo sapiens_hsa002200.91737062
73cAMP signaling pathway_Homo sapiens_hsa040240.89768214
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89024255
75Chemical carcinogenesis_Homo sapiens_hsa052040.88452078
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.87638563
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.87561364
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87192087
79Proteasome_Homo sapiens_hsa030500.85989186
80beta-Alanine metabolism_Homo sapiens_hsa004100.85511966
81Calcium signaling pathway_Homo sapiens_hsa040200.84030419
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82948609
83* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82805750
84Parkinsons disease_Homo sapiens_hsa050120.82742942
85Estrogen signaling pathway_Homo sapiens_hsa049150.81300758
86Basal cell carcinoma_Homo sapiens_hsa052170.80194416
87Arachidonic acid metabolism_Homo sapiens_hsa005900.79045136
88Regulation of autophagy_Homo sapiens_hsa041400.78839015
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78608563
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77925209
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.76873085
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.76624168
93ErbB signaling pathway_Homo sapiens_hsa040120.75665906
94Retinol metabolism_Homo sapiens_hsa008300.75495762
95Thyroid hormone synthesis_Homo sapiens_hsa049180.75254332
96One carbon pool by folate_Homo sapiens_hsa006700.74952616
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72385658
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.71136838
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71076795
100Dilated cardiomyopathy_Homo sapiens_hsa054140.68474393
101Butanoate metabolism_Homo sapiens_hsa006500.68085627
102Ribosome_Homo sapiens_hsa030100.66762021
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64916372
104Metabolic pathways_Homo sapiens_hsa011000.64208317
105Sphingolipid metabolism_Homo sapiens_hsa006000.64037594
106Purine metabolism_Homo sapiens_hsa002300.62597442
107Fat digestion and absorption_Homo sapiens_hsa049750.61885135
108Tyrosine metabolism_Homo sapiens_hsa003500.60985930
109Renal cell carcinoma_Homo sapiens_hsa052110.60689793
110Alcoholism_Homo sapiens_hsa050340.59824027
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58860653
112Circadian rhythm_Homo sapiens_hsa047100.58211370
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.54820129
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53249762
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.53159034
116Tight junction_Homo sapiens_hsa045300.52832381
117Glycerolipid metabolism_Homo sapiens_hsa005610.52188450
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51963610
119Mineral absorption_Homo sapiens_hsa049780.51672912
120Protein export_Homo sapiens_hsa030600.49454097
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47002182
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46496600
123Type I diabetes mellitus_Homo sapiens_hsa049400.46191600
124Histidine metabolism_Homo sapiens_hsa003400.45437355
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42659571
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41797242
127Tryptophan metabolism_Homo sapiens_hsa003800.41670933
128ABC transporters_Homo sapiens_hsa020100.40385254
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39385886
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38006257
131Fatty acid elongation_Homo sapiens_hsa000620.37774333
132Ras signaling pathway_Homo sapiens_hsa040140.37493498
133Choline metabolism in cancer_Homo sapiens_hsa052310.36693704
134Endocytosis_Homo sapiens_hsa041440.36665635
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33644782
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33408077
137Sulfur metabolism_Homo sapiens_hsa009200.32909642
138Dorso-ventral axis formation_Homo sapiens_hsa043200.32561619
139MAPK signaling pathway_Homo sapiens_hsa040100.32400738
140Huntingtons disease_Homo sapiens_hsa050160.31640208
141Fatty acid degradation_Homo sapiens_hsa000710.31098273
142Arginine and proline metabolism_Homo sapiens_hsa003300.30824188
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30788951
144Fatty acid metabolism_Homo sapiens_hsa012120.30653691
145Hippo signaling pathway_Homo sapiens_hsa043900.28613445
146Folate biosynthesis_Homo sapiens_hsa007900.27963217
147Glioma_Homo sapiens_hsa052140.27787300

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