PRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striated muscle atrophy (GO:0014891)9.73673268
2regulation of steroid hormone biosynthetic process (GO:0090030)9.39983137
3seminiferous tubule development (GO:0072520)9.06247889
4skeletal muscle adaptation (GO:0043501)8.65815340
5muscle atrophy (GO:0014889)8.36931697
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)8.35281781
7regulation of inositol phosphate biosynthetic process (GO:0010919)8.34544160
8carnitine shuttle (GO:0006853)8.33444252
9uterus development (GO:0060065)7.07481095
10fatty acid transmembrane transport (GO:1902001)6.99822742
11cellular response to gonadotropin stimulus (GO:0071371)6.91757135
12carnitine transmembrane transport (GO:1902603)6.88574058
13synaptic vesicle maturation (GO:0016188)6.79877263
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.71871375
15DNA integration (GO:0015074)6.62979621
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.61275006
17positive regulation of cAMP-mediated signaling (GO:0043950)6.42180906
18regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24926981
19carnitine transport (GO:0015879)6.24897145
20amino-acid betaine transport (GO:0015838)6.24897145
21regulation of hormone biosynthetic process (GO:0046885)6.20145013
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.08656980
23sulfation (GO:0051923)6.00791973
24locomotory exploration behavior (GO:0035641)5.85304106
25regulation of glycolytic process (GO:0006110)5.84500291
26cellular response to reactive nitrogen species (GO:1902170)5.82314515
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80658459
28positive regulation of tolerance induction (GO:0002645)5.67883032
29cellular response to thyroid hormone stimulus (GO:0097067)5.67657157
30antigen processing and presentation via MHC class Ib (GO:0002475)5.57454094
31regulation of fatty acid oxidation (GO:0046320)5.56738436
32regulation of energy homeostasis (GO:2000505)5.52757944
33gamma-aminobutyric acid transport (GO:0015812)5.46942917
34positive regulation of hormone biosynthetic process (GO:0046886)5.43748282
35regulation of regulatory T cell differentiation (GO:0045589)5.41248460
36intracellular lipid transport (GO:0032365)5.37304199
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37262920
38positive regulation of gluconeogenesis (GO:0045722)5.21920289
39response to methylmercury (GO:0051597)5.17122813
40glutamate secretion (GO:0014047)5.10055725
41glucocorticoid biosynthetic process (GO:0006704)5.09863751
42response to muscle activity (GO:0014850)5.06938429
43regulation of synaptic vesicle exocytosis (GO:2000300)5.03355599
44cellular response to dexamethasone stimulus (GO:0071549)4.98912079
45purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.97299287
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.97299287
47regulation of T cell tolerance induction (GO:0002664)4.96167305
48protein targeting to lysosome (GO:0006622)4.89397812
49establishment of protein localization to vacuole (GO:0072666)4.89397812
50protein targeting to vacuole (GO:0006623)4.89397812
51female gonad development (GO:0008585)4.87580336
52sodium ion export (GO:0071436)4.84839520
53bone resorption (GO:0045453)4.82708402
54flavonoid metabolic process (GO:0009812)4.72410079
55neurotransmitter secretion (GO:0007269)4.71994584
56synaptic vesicle exocytosis (GO:0016079)4.70653019
57vocalization behavior (GO:0071625)4.69986106
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.63724536
59NAD biosynthetic process (GO:0009435)4.62542078
60regulation of type B pancreatic cell apoptotic process (GO:2000674)4.61716519
61response to dexamethasone (GO:0071548)4.60204742
62male genitalia development (GO:0030539)4.59764850
63neuromuscular process controlling posture (GO:0050884)4.51798558
64antigen processing and presentation of endogenous antigen (GO:0019883)4.51481089
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51050818
66regulation of hormone metabolic process (GO:0032350)4.50664658
67phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)4.50065167
68neuron cell-cell adhesion (GO:0007158)4.47189774
69response to epinephrine (GO:0071871)4.46524232
70layer formation in cerebral cortex (GO:0021819)4.44163287
71cellular potassium ion homeostasis (GO:0030007)4.42965091
72regulation of synaptic vesicle transport (GO:1902803)4.41440579
73proline transport (GO:0015824)4.38728515
74regulation of neuronal synaptic plasticity (GO:0048168)4.38210686
75response to gonadotropin (GO:0034698)4.34554075
76negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.33922964
77regulation of lipoprotein metabolic process (GO:0050746)4.33603009
78quaternary ammonium group transport (GO:0015697)4.30310966
79regulation of carbohydrate catabolic process (GO:0043470)4.28805965
80regulation of cellular carbohydrate catabolic process (GO:0043471)4.28805965
81regulation of collateral sprouting (GO:0048670)4.25935391
82ionotropic glutamate receptor signaling pathway (GO:0035235)4.24531605
83galactose metabolic process (GO:0006012)4.22191146
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.21551384
85activation of protein kinase A activity (GO:0034199)4.19919793
86regulation of tolerance induction (GO:0002643)4.19881244
87positive regulation of alcohol biosynthetic process (GO:1902932)4.19608660
88regulation of glutamate receptor signaling pathway (GO:1900449)4.18108001
89exploration behavior (GO:0035640)4.10352903
90positive regulation of fatty acid oxidation (GO:0046321)4.08696254
91regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07524113
92regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.05962339
93response to thyroid hormone (GO:0097066)4.04864325
94synaptic vesicle docking involved in exocytosis (GO:0016081)4.04755737
95response to insecticide (GO:0017085)4.03381026
96cell communication by electrical coupling (GO:0010644)4.02068083
97early endosome to late endosome transport (GO:0045022)3.97052685
98positive regulation of hormone metabolic process (GO:0032352)3.94281135
99negative regulation of myoblast differentiation (GO:0045662)3.92900485
100neurotransmitter transport (GO:0006836)3.92526556
101neuronal action potential propagation (GO:0019227)3.91912069
102cerebellar Purkinje cell layer development (GO:0021680)3.91910657
103plasma membrane repair (GO:0001778)3.87048618
104potassium ion import (GO:0010107)3.81085606
105axonal fasciculation (GO:0007413)3.80501737
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76762843
107positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75995456
108progesterone metabolic process (GO:0042448)3.74594437
109cerebellar Purkinje cell differentiation (GO:0021702)3.73804240
110neuron recognition (GO:0008038)3.73131350
111nicotinamide nucleotide biosynthetic process (GO:0019359)3.70036563
112pyridine nucleotide biosynthetic process (GO:0019363)3.70036563
113negative regulation of receptor activity (GO:2000272)3.65846761
114neuronal ion channel clustering (GO:0045161)3.63679013
115positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.61565691
116regulation of neurotransmitter levels (GO:0001505)3.61408854
117reproductive system development (GO:0061458)3.60707314
118regulation of axon regeneration (GO:0048679)3.59494848
119regulation of neuron projection regeneration (GO:0070570)3.59494848
120keratan sulfate catabolic process (GO:0042340)3.58429855
121protein localization to vacuole (GO:0072665)3.55052334
122protein localization to lysosome (GO:0061462)3.55052334
123regulation of beta-amyloid formation (GO:1902003)3.54910450
124protein localization to synapse (GO:0035418)3.54087176
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50479925
126regulation of autophagic vacuole assembly (GO:2000785)3.50316649
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47464925
128neuromuscular process controlling balance (GO:0050885)3.47280151
129central nervous system myelination (GO:0022010)3.47079722
130axon ensheathment in central nervous system (GO:0032291)3.47079722
131vesicle transport along microtubule (GO:0047496)3.45931140
132glycine transport (GO:0015816)3.44723112
133regulation of cellular respiration (GO:0043457)3.44161299
134potassium ion homeostasis (GO:0055075)3.41326136
135glutamate receptor signaling pathway (GO:0007215)3.38980085
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38869533
137positive regulation of potassium ion transmembrane transport (GO:1901381)3.37828754
138regulation of amyloid precursor protein catabolic process (GO:1902991)3.36495176
139dendritic spine morphogenesis (GO:0060997)3.34624684
140long-term memory (GO:0007616)3.33896974
141regulation of cAMP-mediated signaling (GO:0043949)3.33514407
142L-amino acid import (GO:0043092)3.32390608
143synaptic vesicle endocytosis (GO:0048488)3.31690876
144melanin metabolic process (GO:0006582)3.30911962
145striated muscle adaptation (GO:0014888)3.30697099
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30424114
147melanin biosynthetic process (GO:0042438)3.29757898
148positive regulation of antigen processing and presentation (GO:0002579)3.26183216
149synaptic transmission, glutamatergic (GO:0035249)3.25013944
150dendrite morphogenesis (GO:0048813)3.23946247
151gamma-aminobutyric acid signaling pathway (GO:0007214)3.20450809
152regulation of synapse structural plasticity (GO:0051823)3.19100105
153cellular sodium ion homeostasis (GO:0006883)3.17211064
154mating behavior (GO:0007617)3.17154846
155alanine transport (GO:0032328)3.17055762
156establishment of nucleus localization (GO:0040023)3.16768410
157cellular response to antibiotic (GO:0071236)3.15964201
158membrane depolarization during action potential (GO:0086010)3.13139122
159regulation of clathrin-mediated endocytosis (GO:2000369)3.11935976
160glucocorticoid metabolic process (GO:0008211)3.10624054
161positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07697287
162transmission of nerve impulse (GO:0019226)3.07332830
163androgen metabolic process (GO:0008209)3.05400077
164steroid catabolic process (GO:0006706)3.04641318
165regulation of ARF protein signal transduction (GO:0032012)3.03676465
166organelle transport along microtubule (GO:0072384)3.03226173
167axon cargo transport (GO:0008088)3.03204350
168regulation of vacuole organization (GO:0044088)3.02283567
169neuropeptide signaling pathway (GO:0007218)3.02121752
170secondary metabolite biosynthetic process (GO:0044550)3.01513192
171heparin metabolic process (GO:0030202)3.00256947
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.98735096
173regulation of vesicle fusion (GO:0031338)2.98582686
174regulation of synaptic plasticity (GO:0048167)2.97693326
175positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.95720978
176positive regulation of membrane potential (GO:0045838)2.93978059
177postsynaptic membrane organization (GO:0001941)2.92290197
178neuron-neuron synaptic transmission (GO:0007270)2.90435311
179presynaptic membrane organization (GO:0097090)2.87557388
180acidic amino acid transport (GO:0015800)2.85075262
181response to auditory stimulus (GO:0010996)2.83958151
182adult walking behavior (GO:0007628)2.82226444
183cell communication involved in cardiac conduction (GO:0086065)2.80982139
184L-glutamate transport (GO:0015813)2.80882514
185neurotransmitter-gated ion channel clustering (GO:0072578)2.80410866
186dicarboxylic acid biosynthetic process (GO:0043650)2.78432367
187regulation of neurotransmitter secretion (GO:0046928)2.77107703
188positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76460060
189regulation of calcium ion-dependent exocytosis (GO:0017158)2.75950674
190response to pheromone (GO:0019236)2.75582702
191neurotransmitter catabolic process (GO:0042135)2.73743015
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70993883
193neuromuscular process (GO:0050905)2.70068677
194positive regulation of potassium ion transport (GO:0043268)2.70020978
195amino acid import (GO:0043090)2.63708555
196regulation of postsynaptic membrane potential (GO:0060078)2.63018288
197regulation of synaptic transmission, GABAergic (GO:0032228)2.62594353
198intraspecies interaction between organisms (GO:0051703)2.61763421
199positive regulation of inositol phosphate biosynthetic process (GO:0060732)10.6735377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.15468503
2EZH2_22144423_ChIP-Seq_EOC_Human5.75534943
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.07377335
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.50580851
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84630513
6DROSHA_22980978_ChIP-Seq_HELA_Human2.71526930
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71175438
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.70284066
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69571737
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51342693
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46107503
12REST_21632747_ChIP-Seq_MESCs_Mouse2.45758214
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44909195
14GBX2_23144817_ChIP-Seq_PC3_Human2.43413005
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43077976
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41803629
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41157421
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40843772
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40318580
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40318580
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.33428456
22* PIAS1_25552417_ChIP-Seq_VCAP_Human2.30565958
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26265051
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26080546
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24783662
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19402189
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18109444
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15804699
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15170749
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.13242013
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11244152
32BCAT_22108803_ChIP-Seq_LS180_Human2.06901856
33RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04824628
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01536145
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.99101115
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97142038
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.96006960
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.92133471
39* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.89402472
40AR_21572438_ChIP-Seq_LNCaP_Human1.87968936
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.86320215
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.81721490
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81467087
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80767624
45* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.79993230
46VDR_22108803_ChIP-Seq_LS180_Human1.79477765
47* TCF4_23295773_ChIP-Seq_U87_Human1.69056870
48FUS_26573619_Chip-Seq_HEK293_Human1.67689135
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58648200
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56474135
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56199566
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47833322
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47633936
54EWS_26573619_Chip-Seq_HEK293_Human1.46499290
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42890446
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.42247910
57ZNF274_21170338_ChIP-Seq_K562_Hela1.41601387
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40679234
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39120049
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38473403
61SMAD4_21799915_ChIP-Seq_A2780_Human1.38111016
62JUN_21703547_ChIP-Seq_K562_Human1.37549109
63KDM2B_26808549_Chip-Seq_K562_Human1.35781933
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.35233728
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.32770626
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31484277
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30233790
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.30190187
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.30124066
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29767747
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29767747
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29154831
73* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27028484
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.26558876
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25053257
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23131742
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22815941
78P53_22387025_ChIP-Seq_ESCs_Mouse1.22778617
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21136480
80* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20359162
81* TAF15_26573619_Chip-Seq_HEK293_Human1.19631495
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18454406
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17627204
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.16455875
85AR_19668381_ChIP-Seq_PC3_Human1.16280463
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16207327
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16106002
88* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15925837
89* CBP_20019798_ChIP-Seq_JUKART_Human1.15925837
90RUNX2_22187159_ChIP-Seq_PCA_Human1.15808384
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.15476663
92* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15417335
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15036697
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14031188
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13526052
96ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12859379
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11375534
98RXR_22108803_ChIP-Seq_LS180_Human1.11015244
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.10903816
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10848195
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10848195
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10549366
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10433302
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09206395
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08998751
106TCF4_22108803_ChIP-Seq_LS180_Human1.08178935
107* SMAD3_21741376_ChIP-Seq_HESCs_Human1.07777293
108ETV1_20927104_ChIP-Seq_GIST48_Human1.07501180
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.06111487
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05536136
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04729999
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04295114
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03260549
114CJUN_26792858_Chip-Seq_BT549_Human1.02704345
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.02492641
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.02128086
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.01979641
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01799801
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01568419
120MITF_21258399_ChIP-Seq_MELANOMA_Human1.01224064
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01130138
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.99727533
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99693670
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99305492
125SMRT_27268052_Chip-Seq_Bcells_Human0.98536372
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98514100
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97290379
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97270026
129* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96810432
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96408265
131TP53_16413492_ChIP-PET_HCT116_Human0.96355651
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96323539
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96078549
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95973498
135TFEB_21752829_ChIP-Seq_HELA_Human0.95868359
136* SMAD3_21741376_ChIP-Seq_EPCs_Human0.95646666
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95557193
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95252968
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.94416646
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94026739
141AR_25329375_ChIP-Seq_VCAP_Human0.93923214
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93748172
143CTCF_27219007_Chip-Seq_Bcells_Human0.93498057
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93469349
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93327135
146STAT3_23295773_ChIP-Seq_U87_Human0.93020476
147AHR_22903824_ChIP-Seq_MCF-7_Human0.92919245
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.92844386
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.92700774
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92539609
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91838257
152TRIM28_21343339_ChIP-Seq_HEK293_Human0.91738433
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90817826
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90623921
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.87905086
156KDM2B_26808549_Chip-Seq_DND41_Human0.86646003
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.86485478
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85699929
159P300_19829295_ChIP-Seq_ESCs_Human0.85615097
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85218612
161KLF4_19829295_ChIP-Seq_ESCs_Human0.84898766
162GATA1_19941826_ChIP-Seq_K562_Human0.84517707
163LXR_22292898_ChIP-Seq_THP-1_Human0.83836760
164* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83664346
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.83379745
166TP53_18474530_ChIP-ChIP_U2OS_Human0.82575510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25134858
2MP0003646_muscle_fatigue6.22637395
3MP0005187_abnormal_penis_morphology5.11545627
4MP0003880_abnormal_central_pattern4.78259558
5MP0003315_abnormal_perineum_morphology4.76049844
6MP0001919_abnormal_reproductive_system4.16946124
7MP0003635_abnormal_synaptic_transmissio3.80093813
8MP0005257_abnormal_intraocular_pressure3.69731351
9MP0005423_abnormal_somatic_nervous3.62767978
10MP0001968_abnormal_touch/_nociception3.24159780
11MP0009745_abnormal_behavioral_response3.16720370
12MP0002064_seizures3.15056312
13MP0004270_analgesia3.08658721
14MP0003122_maternal_imprinting2.89919682
15MP0009046_muscle_twitch2.78949386
16* MP0000631_abnormal_neuroendocrine_gland2.77966245
17MP0002063_abnormal_learning/memory/cond2.73270690
18MP0002971_abnormal_brown_adipose2.66935835
19MP0008995_early_reproductive_senescence2.59678128
20MP0005647_abnormal_sex_gland2.57678503
21MP0005171_absent_coat_pigmentation2.52699445
22MP0005389_reproductive_system_phenotype2.52574280
23MP0005408_hypopigmentation2.29701413
24MP0005451_abnormal_body_composition2.26791494
25MP0002572_abnormal_emotion/affect_behav2.26525930
26MP0001529_abnormal_vocalization2.24568272
27MP0001501_abnormal_sleep_pattern2.24314734
28MP0002272_abnormal_nervous_system2.22740275
29MP0003329_amyloid_beta_deposits2.20535028
30MP0002909_abnormal_adrenal_gland2.18235387
31MP0004885_abnormal_endolymph2.11692802
32MP0003690_abnormal_glial_cell2.10297190
33MP0009780_abnormal_chondrocyte_physiolo2.09864022
34MP0002734_abnormal_mechanical_nocicepti2.03883438
35MP0001486_abnormal_startle_reflex2.00356079
36MP0005645_abnormal_hypothalamus_physiol1.96420387
37MP0000569_abnormal_digit_pigmentation1.95086402
38MP0003183_abnormal_peptide_metabolism1.94657930
39MP0004858_abnormal_nervous_system1.91524301
40MP0003787_abnormal_imprinting1.89719509
41MP0000372_irregular_coat_pigmentation1.85123738
42MP0001542_abnormal_bone_strength1.80443446
43MP0002733_abnormal_thermal_nociception1.79612034
44MP0003123_paternal_imprinting1.70537661
45MP0004811_abnormal_neuron_physiology1.70117068
46MP0001440_abnormal_grooming_behavior1.68721687
47MP0002067_abnormal_sensory_capabilities1.68134730
48MP0003172_abnormal_lysosome_physiology1.66061968
49MP0008569_lethality_at_weaning1.64047880
50MP0002736_abnormal_nociception_after1.63799298
51MP0003283_abnormal_digestive_organ1.63032736
52MP0000751_myopathy1.62733806
53MP0001970_abnormal_pain_threshold1.60690619
54MP0003633_abnormal_nervous_system1.54989359
55MP0005085_abnormal_gallbladder_physiolo1.51798917
56MP0000778_abnormal_nervous_system1.48017300
57MP0008260_abnormal_autophagy1.47146555
58MP0000955_abnormal_spinal_cord1.44925423
59MP0000920_abnormal_myelination1.44555170
60* MP0005646_abnormal_pituitary_gland1.42258003
61MP0002557_abnormal_social/conspecific_i1.38661559
62MP0004924_abnormal_behavior1.38602570
63MP0005386_behavior/neurological_phenoty1.38602570
64MP0002269_muscular_atrophy1.37125315
65MP0002184_abnormal_innervation1.36985408
66MP0002735_abnormal_chemical_nociception1.33302319
67MP0005623_abnormal_meninges_morphology1.32301710
68MP0002066_abnormal_motor_capabilities/c1.31482760
69MP0006276_abnormal_autonomic_nervous1.28883045
70MP0000604_amyloidosis1.26645503
71MP0008961_abnormal_basal_metabolism1.24302413
72MP0003631_nervous_system_phenotype1.23842592
73MP0003075_altered_response_to1.19683427
74MP0002970_abnormal_white_adipose1.18234399
75MP0002882_abnormal_neuron_morphology1.16035391
76MP0000013_abnormal_adipose_tissue1.13283981
77MP0001177_atelectasis1.09973109
78MP0003632_abnormal_nervous_system1.08750928
79MP0005075_abnormal_melanosome_morpholog1.08550578
80MP0003634_abnormal_glial_cell1.07576083
81MP0004142_abnormal_muscle_tone1.07291284
82MP0003121_genomic_imprinting1.05669306
83MP0004145_abnormal_muscle_electrophysio1.05360487
84MP0005058_abnormal_lysosome_morphology1.02920095
85MP0010234_abnormal_vibrissa_follicle1.02498657
86MP0004484_altered_response_of1.01272707
87MP0006138_congestive_heart_failure1.00116512
88MP0004043_abnormal_pH_regulation0.99538058
89MP0005167_abnormal_blood-brain_barrier0.98396446
90MP0002229_neurodegeneration0.98323083
91MP0001324_abnormal_eye_pigmentation0.97038581
92MP0008874_decreased_physiological_sensi0.96460328
93MP0002837_dystrophic_cardiac_calcinosis0.95927694
94MP0002332_abnormal_exercise_endurance0.94367654
95* MP0001905_abnormal_dopamine_level0.92801935
96MP0001502_abnormal_circadian_rhythm0.92164180
97MP0000747_muscle_weakness0.90454205
98* MP0002152_abnormal_brain_morphology0.90087299
99MP0002069_abnormal_eating/drinking_beha0.87800113
100MP0000681_abnormal_thyroid_gland0.87315841
101MP0001299_abnormal_eye_distance/0.84792954
102MP0009115_abnormal_fat_cell0.84436604
103MP0003195_calcinosis0.83282269
104MP0004130_abnormal_muscle_cell0.81897151
105MP0003806_abnormal_nucleotide_metabolis0.80678278
106MP0008875_abnormal_xenobiotic_pharmacok0.80152936
107MP0003879_abnormal_hair_cell0.80071114
108MP0005535_abnormal_body_temperature0.79463322
109MP0008872_abnormal_physiological_respon0.78392513
110MP0003950_abnormal_plasma_membrane0.77377054
111MP0005334_abnormal_fat_pad0.76410444
112MP0000371_diluted_coat_color0.75728142
113MP0003137_abnormal_impulse_conducting0.74999098
114MP0002638_abnormal_pupillary_reflex0.72915197
115MP0002095_abnormal_skin_pigmentation0.72623097
116MP0009840_abnormal_foam_cell0.71740460
117MP0000639_abnormal_adrenal_gland0.70253777
118MP0004085_abnormal_heartbeat0.70244687
119MP0002089_abnormal_postnatal_growth/wei0.70026488
120MP0003045_fibrosis0.66245126
121MP0005165_increased_susceptibility_to0.65789121
122MP0005551_abnormal_eye_electrophysiolog0.65609098
123MP0000015_abnormal_ear_pigmentation0.63341924
124MP0005266_abnormal_metabolism0.58668704
125MP0004233_abnormal_muscle_weight0.58413455
126MP0001984_abnormal_olfaction0.58340938
127MP0001348_abnormal_lacrimal_gland0.58005874
128MP0005360_urolithiasis0.57179383
129MP0002822_catalepsy0.56945221
130MP0002078_abnormal_glucose_homeostasis0.56730936
131MP0003953_abnormal_hormone_level0.56430572
132MP0002139_abnormal_hepatobiliary_system0.56406018
133MP0005448_abnormal_energy_balance0.55996777
134MP0001943_abnormal_respiration0.54487447
135MP0010386_abnormal_urinary_bladder0.53764698
136MP0005197_abnormal_uvea_morphology0.53727345
137MP0001186_pigmentation_phenotype0.53530755
138MP0005379_endocrine/exocrine_gland_phen0.53392278
139MP0010769_abnormal_survival0.52831974
140MP0002082_postnatal_lethality0.52243156
141MP0010770_preweaning_lethality0.52243156
142MP0005166_decreased_susceptibility_to0.52060305
143MP0004215_abnormal_myocardial_fiber0.51431310
144MP0002090_abnormal_vision0.51230173
145MP0003786_premature_aging0.50201553
146MP0006036_abnormal_mitochondrial_physio0.48941294
147MP0002075_abnormal_coat/hair_pigmentati0.48247396
148MP0008770_decreased_survivor_rate0.47882532
149MP0001119_abnormal_female_reproductive0.47561840
150MP0002106_abnormal_muscle_physiology0.47403722
151MP0005332_abnormal_amino_acid0.46562649
152MP0003959_abnormal_lean_body0.45987748
153MP0000647_abnormal_sebaceous_gland0.45735464
154MP0005620_abnormal_muscle_contractility0.42462392
155MP0004381_abnormal_hair_follicle0.40748551

Predicted human phenotypes

RankGene SetZ-score
1Enlarged penis (HP:0000040)9.89758563
2Gonadotropin excess (HP:0000837)9.30948491
3Asymmetric septal hypertrophy (HP:0001670)9.26170852
4Neonatal hypoglycemia (HP:0001998)8.99066896
5Focal motor seizures (HP:0011153)5.85800061
6Bundle branch block (HP:0011710)5.75258778
7Absent frontal sinuses (HP:0002688)5.20156559
8Atrioventricular block (HP:0001678)5.16431733
9Myokymia (HP:0002411)5.05567033
10Visual hallucinations (HP:0002367)4.89230953
11Focal seizures (HP:0007359)4.85508585
12Papilledema (HP:0001085)4.71044325
13Supranuclear gaze palsy (HP:0000605)4.61335882
14Spondylolisthesis (HP:0003302)4.32136874
15Testicular neoplasm (HP:0010788)4.28721859
16Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.98769696
17Persistence of primary teeth (HP:0006335)3.90098365
18Abnormal eating behavior (HP:0100738)3.89485605
19Absence seizures (HP:0002121)3.81264876
20Autoamputation (HP:0001218)3.76130463
21Osteolytic defects of the hand bones (HP:0009699)3.74551167
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.74551167
23Generalized tonic-clonic seizures (HP:0002069)3.71670041
24Hypoglycemic seizures (HP:0002173)3.66632527
25Abnormality of the anterior horn cell (HP:0006802)3.65607638
26Degeneration of anterior horn cells (HP:0002398)3.65607638
27Congenital ichthyosiform erythroderma (HP:0007431)3.63854210
28Hypokalemic alkalosis (HP:0001949)3.59460330
29Atonic seizures (HP:0010819)3.57971893
30Hypergonadotropic hypogonadism (HP:0000815)3.55880103
31Neurofibrillary tangles (HP:0002185)3.50002568
32Ankle clonus (HP:0011448)3.46649388
33Postural instability (HP:0002172)3.46063040
34Palpitations (HP:0001962)3.45827035
35Depression (HP:0000716)3.45715361
36Action tremor (HP:0002345)3.43139240
37Ventricular fibrillation (HP:0001663)3.38165840
38Bradycardia (HP:0001662)3.36811954
39Dialeptic seizures (HP:0011146)3.33651343
40Cerebral inclusion bodies (HP:0100314)3.33403652
41Epileptic encephalopathy (HP:0200134)3.32089365
42Mutism (HP:0002300)3.25056921
43Hemiplegia (HP:0002301)3.24091786
44Abnormality of liposaccharide metabolism (HP:0010968)3.20896733
45Abnormality of glycosphingolipid metabolism (HP:0004343)3.20896733
46Abnormality of glycolipid metabolism (HP:0010969)3.20896733
47Abnormality of the frontal sinuses (HP:0002687)3.13294923
48Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.12707990
49Progressive cerebellar ataxia (HP:0002073)3.11577967
50Agitation (HP:0000713)3.11541507
51Abnormality of the lower motor neuron (HP:0002366)3.09916245
52Heart block (HP:0012722)3.04880877
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.99747212
54Anxiety (HP:0000739)2.93806168
55Spinal muscular atrophy (HP:0007269)2.92220562
56Abnormal atrioventricular conduction (HP:0005150)2.89085273
57Insomnia (HP:0100785)2.85597797
58Intention tremor (HP:0002080)2.85389894
59Hammertoe (HP:0001765)2.81566647
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81378177
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.81378177
62Dysmetria (HP:0001310)2.79713836
63Cerebral aneurysm (HP:0004944)2.79624707
64Febrile seizures (HP:0002373)2.77970598
65Impaired vibration sensation in the lower limbs (HP:0002166)2.77812862
66Ridged nail (HP:0001807)2.74222412
67Proximal tubulopathy (HP:0000114)2.73236718
68Urinary bladder sphincter dysfunction (HP:0002839)2.72307357
69Dysdiadochokinesis (HP:0002075)2.71733074
70Impaired social interactions (HP:0000735)2.70234182
71Abnormal social behavior (HP:0012433)2.70234182
72Progressive inability to walk (HP:0002505)2.68652186
73Spastic gait (HP:0002064)2.68276282
74Generalized aminoaciduria (HP:0002909)2.67631130
75Pheochromocytoma (HP:0002666)2.66433400
76Macroorchidism (HP:0000053)2.59748777
77Truncal ataxia (HP:0002078)2.59567882
78Steppage gait (HP:0003376)2.59001678
79Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.58492140
80Hyperpituitarism (HP:0010514)2.54916633
81Status epilepticus (HP:0002133)2.54900227
82Urinary urgency (HP:0000012)2.54665783
83Torticollis (HP:0000473)2.54240463
84Poor eye contact (HP:0000817)2.54162186
85Delayed closure of the anterior fontanelle (HP:0001476)2.47876288
86Hemiparesis (HP:0001269)2.47192254
87Renal cortical cysts (HP:0000803)2.46318641
88Acne (HP:0001061)2.44820085
89Symptomatic seizures (HP:0011145)2.44790809
90Tongue fasciculations (HP:0001308)2.42067980
91Bradykinesia (HP:0002067)2.41835912
92Cardiomegaly (HP:0001640)2.39986711
93Abnormality of proline metabolism (HP:0010907)2.39220008
94Hydroxyprolinuria (HP:0003080)2.39220008
95Urinary glycosaminoglycan excretion (HP:0003541)2.37713517
96Mucopolysacchariduria (HP:0008155)2.37713517
97Abnormality of the corticospinal tract (HP:0002492)2.36348536
98Psychosis (HP:0000709)2.36275031
99Syringomyelia (HP:0003396)2.36157905
100Spinal cord lesions (HP:0100561)2.36157905
101Rapidly progressive (HP:0003678)2.33577495
102Lower limb muscle weakness (HP:0007340)2.32967556
103Termporal pattern (HP:0011008)2.31957698
104Insidious onset (HP:0003587)2.31957698
105Abnormality of the periventricular white matter (HP:0002518)2.31763390
106Peripheral hypomyelination (HP:0007182)2.31488630
107Accelerated skeletal maturation (HP:0005616)2.30041475
108Neuronal loss in central nervous system (HP:0002529)2.28580075
109Alacrima (HP:0000522)2.28268649
110Drooling (HP:0002307)2.26177015
111Excessive salivation (HP:0003781)2.26177015
112Hypercortisolism (HP:0001578)2.26161711
113Polyphagia (HP:0002591)2.23680164
114Scanning speech (HP:0002168)2.23273647
115Neuroendocrine neoplasm (HP:0100634)2.23092944
116Abnormality of binocular vision (HP:0011514)2.23017960
117Diplopia (HP:0000651)2.23017960
118Focal dystonia (HP:0004373)2.22031845
119Genetic anticipation (HP:0003743)2.21904864
120Broad-based gait (HP:0002136)2.21715331
121Generalized hypopigmentation (HP:0007513)2.19725941
122Hoarse voice (HP:0001609)2.16793519
123Muscle fibrillation (HP:0010546)2.15962469
124Clonus (HP:0002169)2.15517727
125Emotional lability (HP:0000712)2.14690814
126Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12299588
127Abnormality of polysaccharide metabolism (HP:0011012)2.12299588
128Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12299588
129Dysostosis multiplex (HP:0000943)2.10971381
130Turricephaly (HP:0000262)2.10161816
131Rigidity (HP:0002063)2.09526700
132Craniofacial dystonia (HP:0012179)2.07940624
133Dementia (HP:0000726)2.03567329
134Generalized myoclonic seizures (HP:0002123)2.02286299
135Frequent falls (HP:0002359)2.01934737
136Bronchomalacia (HP:0002780)2.01019767
137Attention deficit hyperactivity disorder (HP:0007018)1.99770265
138Lower limb amyotrophy (HP:0007210)1.98575717
139Increased circulating renin level (HP:0000848)1.98504317
140Generalized hypopigmentation of hair (HP:0011358)1.98215332
141Foot dorsiflexor weakness (HP:0009027)1.96822519
142Neoplasm of the heart (HP:0100544)1.96525892
143Ulnar claw (HP:0001178)1.96121899
144Aplasia involving bones of the extremities (HP:0009825)1.94139038
145Aplasia involving bones of the upper limbs (HP:0009823)1.94139038
146Aplasia of the phalanges of the hand (HP:0009802)1.94139038
147Impaired smooth pursuit (HP:0007772)1.93695778
148Palpebral edema (HP:0100540)1.93234345
149Abnormality of the foot musculature (HP:0001436)1.92858211
150Hypoventilation (HP:0002791)1.92384684
151Hyperventilation (HP:0002883)1.92060901
152Ovoid vertebral bodies (HP:0003300)1.91953047
153Atrial fibrillation (HP:0005110)1.91182597
154Decreased lacrimation (HP:0000633)1.90872367
155Abnormal EKG (HP:0003115)1.90636572
156Ventricular arrhythmia (HP:0004308)1.89482561
157Tetraplegia (HP:0002445)1.89441573
158Fetal akinesia sequence (HP:0001989)1.89186983
159Failure to thrive in infancy (HP:0001531)1.88801977
160Striae distensae (HP:0001065)1.86532548
161Postural tremor (HP:0002174)1.86484846
162Restlessness (HP:0000711)1.86062309
163Hyperacusis (HP:0010780)1.84265342
164Nausea (HP:0002018)1.83660695
165EEG with generalized epileptiform discharges (HP:0011198)1.83496739
166Male infertility (HP:0003251)1.83137196
167Primary atrial arrhythmia (HP:0001692)1.82974680
168Menstrual irregularities (HP:0000858)1.81565916
169Epileptiform EEG discharges (HP:0011182)1.80870261
170Blue irides (HP:0000635)1.80124047
171Hypsarrhythmia (HP:0002521)1.79386841
172Spastic paraplegia (HP:0001258)1.78577081
173Megalencephaly (HP:0001355)1.78044446
174Atrophy/Degeneration involving motor neurons (HP:0007373)1.77241733
175Pointed chin (HP:0000307)1.77208591
176Supraventricular tachycardia (HP:0004755)1.76364522
177Neoplasm of the peripheral nervous system (HP:0100007)1.75301478
178Stroke (HP:0001297)1.74820437
179Decreased motor nerve conduction velocity (HP:0003431)1.74797151
180Hypoglycemic coma (HP:0001325)1.74110692
181Supraventricular arrhythmia (HP:0005115)1.72554855
182Decreased testicular size (HP:0008734)1.71661066
183Abnormality of complement system (HP:0005339)1.71089190
184Cerebral palsy (HP:0100021)1.71037516
185Paraplegia (HP:0010550)1.71020469
186Alkalosis (HP:0001948)1.70490356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.17007158
2EEF2K4.90353885
3MAPKAPK34.87530950
4TRPM74.26326075
5MAP3K93.46787384
6WNK33.12930883
7MAP3K43.03115795
8PRKAA22.98097657
9ZAK2.85576172
10EIF2AK32.84852903
11MARK12.82566420
12PAK62.78450735
13MUSK2.76312680
14DYRK32.67216551
15MINK12.54640742
16MAP3K122.51489652
17MAP2K42.40437065
18BMPR1B2.35931489
19NTRK22.35102689
20NTRK12.32249890
21KSR22.21344469
22UHMK12.08073966
23CCNB12.07946854
24EPHA42.03175795
25AKT21.97061518
26MAP2K71.91891584
27TNIK1.85987727
28ALK1.75593611
29NLK1.73426984
30MAPKAPK51.69013033
31CSNK1A1L1.59991939
32TAF11.57544641
33ACVR1B1.57166086
34LMTK21.54678777
35PRKD31.54428361
36FES1.54036778
37PAK31.52544104
38CAMKK11.52284894
39CDK51.51083475
40PRKCH1.50717477
41STK381.46633630
42SCYL21.44600761
43CSNK1G31.43452979
44MAPK121.40754626
45AKT31.39536412
46BCR1.36091138
47MAP3K21.35522163
48LATS21.34283055
49FRK1.31927825
50TAOK31.31880354
51MAP3K131.31187869
52RIPK41.30756157
53MAP3K61.27231165
54CSNK1G11.18349554
55PHKG11.18130155
56PHKG21.18130155
57SIK21.16747878
58GRK51.16502755
59CDK191.16289929
60TIE11.13062290
61DAPK21.12567261
62CDC42BPA1.10329948
63RIPK11.08935393
64RET1.04581250
65NEK91.03419901
66RPS6KB21.03233785
67PRKCG1.01739538
68OBSCN1.00242332
69CAMK1G0.97891624
70MAPK130.97560796
71SGK2230.95741840
72SGK4940.95741840
73EPHA30.95143976
74KSR10.94143492
75NEK10.89724216
76PLK20.87580060
77ERBB30.86669677
78TYRO30.84748899
79FER0.82379885
80PNCK0.82371051
81SGK30.82200709
82MAP3K10.80948619
83CAMK2A0.80361775
84CAMK10.80065725
85PKN20.76298174
86FLT30.75859437
87CDK150.74978746
88BMPR20.73090950
89CDK140.72248543
90CDK180.71795526
91TNK20.70893315
92CAMK2B0.69694276
93DDR20.69487661
94PDGFRA0.68553170
95MAP3K70.67603926
96WNK10.67283089
97ROCK20.66753178
98STK110.66339922
99SGK20.65311815
100PDK10.65067207
101RPS6KA30.63047152
102CSNK1G20.62684537
103BMX0.62189032
104MAPK100.61824752
105PRKAA10.61666763
106CDK11A0.61551509
107CDK60.60800098
108OXSR10.59420064
109ERBB20.57565643
110CAMK2D0.57178784
111CDK80.56035595
112EPHB10.55836059
113PDPK10.55277564
114FYN0.54301619
115SGK10.53679542
116DMPK0.53266673
117TAOK10.53058570
118CAMK2G0.52864407
119ARAF0.52499109
120IGF1R0.51160453
121PRKG10.50923980
122CAMK1D0.50316253
123JAK30.49602216
124ROCK10.49032860
125PRKD10.48282590
126MAPK110.47441852
127PRPF4B0.46493196
128MAPK70.44891237
129RPS6KA20.44768760
130FGFR20.43786297
131RAF10.42896703
132INSRR0.42659653
133JAK20.42129292
134PRKACA0.40866968
135PRKCZ0.40395025
136PRKACG0.40313224
137SRC0.38016508
138JAK10.37919766
139TEC0.37720443
140PRKCB0.37034806
141MELK0.36980456
142LIMK10.36603636
143PINK10.36590372
144DAPK10.36512315
145TRIB30.36060098
146DYRK1A0.35696896
147HIPK20.34784947
148TESK10.34714416
149PRKCE0.34236457
150PLK30.34179653
151MAP3K110.34060024
152ICK0.33206074
153RPS6KB10.32714418
154MAPK40.32505380
155MARK20.32312060
156FGFR30.31958807
157MAPK30.31682098
158PKN10.29793764
159KIT0.29246738
160CASK0.28304971
161CSNK1D0.26251961
162CLK10.25610505
163CDK40.25513478
164TGFBR20.23942004
165MAPK80.21569257
166PDGFRB0.18829120
167ADRBK10.18361965
168KDR0.18351676
169PRKACB0.17424345

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.46454630
2Circadian rhythm_Homo sapiens_hsa047104.44037646
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.75898269
4Lysosome_Homo sapiens_hsa041423.39900398
5Nicotine addiction_Homo sapiens_hsa050333.33002417
6Glycosaminoglycan degradation_Homo sapiens_hsa005313.22852361
7Nitrogen metabolism_Homo sapiens_hsa009103.15199431
8GABAergic synapse_Homo sapiens_hsa047273.11086544
9Synaptic vesicle cycle_Homo sapiens_hsa047212.95728610
10ABC transporters_Homo sapiens_hsa020102.71302970
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.53376784
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53141977
13Circadian entrainment_Homo sapiens_hsa047132.31310538
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.26765197
15Allograft rejection_Homo sapiens_hsa053302.19329461
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19138666
17* Prolactin signaling pathway_Homo sapiens_hsa049172.16836799
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.16696908
19Morphine addiction_Homo sapiens_hsa050322.14013760
20Autoimmune thyroid disease_Homo sapiens_hsa053202.11700740
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11187974
22Glutamatergic synapse_Homo sapiens_hsa047242.10567211
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10379693
24Long-term potentiation_Homo sapiens_hsa047202.07938331
25Sulfur relay system_Homo sapiens_hsa041222.05945794
26Olfactory transduction_Homo sapiens_hsa047402.03999265
27Graft-versus-host disease_Homo sapiens_hsa053321.98872772
28Salivary secretion_Homo sapiens_hsa049701.92407075
29Insulin secretion_Homo sapiens_hsa049111.92216118
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.91912439
31Gastric acid secretion_Homo sapiens_hsa049711.83744708
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81810673
33Amphetamine addiction_Homo sapiens_hsa050311.76742765
34Viral myocarditis_Homo sapiens_hsa054161.75004077
35AMPK signaling pathway_Homo sapiens_hsa041521.69770564
36Phagosome_Homo sapiens_hsa041451.61970229
37Dopaminergic synapse_Homo sapiens_hsa047281.61882449
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54674217
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53443104
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49435810
41Renin secretion_Homo sapiens_hsa049241.46647814
42Type II diabetes mellitus_Homo sapiens_hsa049301.45286554
43Arginine biosynthesis_Homo sapiens_hsa002201.43993878
44GnRH signaling pathway_Homo sapiens_hsa049121.39684492
45Bile secretion_Homo sapiens_hsa049761.39060873
46Cholinergic synapse_Homo sapiens_hsa047251.37137377
47Cocaine addiction_Homo sapiens_hsa050301.36419616
48Insulin resistance_Homo sapiens_hsa049311.32787117
49Taste transduction_Homo sapiens_hsa047421.32665883
50Long-term depression_Homo sapiens_hsa047301.27644178
51Oxytocin signaling pathway_Homo sapiens_hsa049211.20384671
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20072309
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18163814
54Serotonergic synapse_Homo sapiens_hsa047261.13771689
55Gap junction_Homo sapiens_hsa045401.13473677
56Butanoate metabolism_Homo sapiens_hsa006501.12929826
57Estrogen signaling pathway_Homo sapiens_hsa049151.10799035
58Calcium signaling pathway_Homo sapiens_hsa040201.07562249
59Rheumatoid arthritis_Homo sapiens_hsa053231.06590653
60Prion diseases_Homo sapiens_hsa050201.04829620
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03996314
62cAMP signaling pathway_Homo sapiens_hsa040241.03902082
63Dorso-ventral axis formation_Homo sapiens_hsa043201.02642709
64Apoptosis_Homo sapiens_hsa042101.01725725
65Selenocompound metabolism_Homo sapiens_hsa004501.00999540
66Axon guidance_Homo sapiens_hsa043601.00094533
67Vibrio cholerae infection_Homo sapiens_hsa051100.97799426
68Melanogenesis_Homo sapiens_hsa049160.95427387
69Thyroid hormone synthesis_Homo sapiens_hsa049180.94456836
70Dilated cardiomyopathy_Homo sapiens_hsa054140.92723498
71ECM-receptor interaction_Homo sapiens_hsa045120.91454528
72Collecting duct acid secretion_Homo sapiens_hsa049660.90890614
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90817914
74Regulation of autophagy_Homo sapiens_hsa041400.90369993
75Antigen processing and presentation_Homo sapiens_hsa046120.86585309
76Cardiac muscle contraction_Homo sapiens_hsa042600.84473368
77Glioma_Homo sapiens_hsa052140.83063170
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82556117
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79702914
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78417142
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77378488
82ErbB signaling pathway_Homo sapiens_hsa040120.74373303
83FoxO signaling pathway_Homo sapiens_hsa040680.73742744
84Vitamin digestion and absorption_Homo sapiens_hsa049770.72251892
85Type I diabetes mellitus_Homo sapiens_hsa049400.71404007
86Propanoate metabolism_Homo sapiens_hsa006400.70364771
87Pancreatic secretion_Homo sapiens_hsa049720.69975709
88Sphingolipid metabolism_Homo sapiens_hsa006000.68366319
89Ovarian steroidogenesis_Homo sapiens_hsa049130.68142733
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67634605
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.67162355
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.66492873
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.65779591
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65516724
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65502731
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64956381
97Other glycan degradation_Homo sapiens_hsa005110.64579007
98Glucagon signaling pathway_Homo sapiens_hsa049220.63505050
99Thyroid cancer_Homo sapiens_hsa052160.63292504
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62690699
101Oocyte meiosis_Homo sapiens_hsa041140.62298144
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61296177
103MAPK signaling pathway_Homo sapiens_hsa040100.59643519
104Ether lipid metabolism_Homo sapiens_hsa005650.59638308
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55611165
106Galactose metabolism_Homo sapiens_hsa000520.54807466
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54742838
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52467308
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.50832321
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49764588
111* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48949751
112Fructose and mannose metabolism_Homo sapiens_hsa000510.48798450
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.47856045
114Glycerolipid metabolism_Homo sapiens_hsa005610.47061141
115Insulin signaling pathway_Homo sapiens_hsa049100.44225809
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43907879
117Fatty acid elongation_Homo sapiens_hsa000620.43720778
118Fatty acid biosynthesis_Homo sapiens_hsa000610.42890004
119Complement and coagulation cascades_Homo sapiens_hsa046100.39711813
120Endocytosis_Homo sapiens_hsa041440.38858989
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38089678
122Small cell lung cancer_Homo sapiens_hsa052220.35953464
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35700899
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35339269
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35085230
126Rap1 signaling pathway_Homo sapiens_hsa040150.35026419
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34519728
128Choline metabolism in cancer_Homo sapiens_hsa052310.34489135
129Fatty acid metabolism_Homo sapiens_hsa012120.33717652
130Ras signaling pathway_Homo sapiens_hsa040140.33436710
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33392931
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32833064
133Lysine degradation_Homo sapiens_hsa003100.32627354
134Tryptophan metabolism_Homo sapiens_hsa003800.29715515
135Tuberculosis_Homo sapiens_hsa051520.29691725
136VEGF signaling pathway_Homo sapiens_hsa043700.29606044
137Platelet activation_Homo sapiens_hsa046110.29139859
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28763692
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27999955
140mTOR signaling pathway_Homo sapiens_hsa041500.27519086
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27387191
142Renal cell carcinoma_Homo sapiens_hsa052110.26637750
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25190538
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24690219
145Tyrosine metabolism_Homo sapiens_hsa003500.24185653
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.24080986
147Colorectal cancer_Homo sapiens_hsa052100.23374178
148Inositol phosphate metabolism_Homo sapiens_hsa005620.23347632
149PPAR signaling pathway_Homo sapiens_hsa033200.22648769
150Biosynthesis of amino acids_Homo sapiens_hsa012300.22348587
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.21838046
152Starch and sucrose metabolism_Homo sapiens_hsa005000.20626223
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.20301328
154Amoebiasis_Homo sapiens_hsa051460.20237976
155Pancreatic cancer_Homo sapiens_hsa052120.14792218
156Viral carcinogenesis_Homo sapiens_hsa052030.14033707
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13161908
158Salmonella infection_Homo sapiens_hsa051320.12165476
159Adherens junction_Homo sapiens_hsa045200.11072083
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09073032
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.08937214
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08213127
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.07771161
164Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05380826
165Vitamin B6 metabolism_Homo sapiens_hsa007500.04479626

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