PRKD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.07599427
2Golgi transport vesicle coating (GO:0048200)5.07599427
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.89036853
4presynaptic membrane assembly (GO:0097105)3.83018763
5type B pancreatic cell development (GO:0003323)3.62053375
6protein retention in ER lumen (GO:0006621)3.58774015
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.46056266
8COPII vesicle coating (GO:0048208)3.36570931
9anterior/posterior axis specification, embryo (GO:0008595)3.35051146
10glandular epithelial cell development (GO:0002068)3.22436688
11presynaptic membrane organization (GO:0097090)3.20858710
12L-serine metabolic process (GO:0006563)3.18638831
13protein localization to synapse (GO:0035418)3.12710327
14artery development (GO:0060840)3.08060762
15axonal fasciculation (GO:0007413)3.08013198
16notochord development (GO:0030903)3.06534341
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05340992
18protein maturation by protein folding (GO:0022417)3.04445372
19branching involved in prostate gland morphogenesis (GO:0060442)3.02106971
20auditory receptor cell differentiation (GO:0042491)3.00341234
21branched-chain amino acid catabolic process (GO:0009083)3.00133073
22metanephric mesenchyme development (GO:0072075)2.95482060
23postsynaptic membrane organization (GO:0001941)2.93408361
24membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87807678
25neuron cell-cell adhesion (GO:0007158)2.87773852
26regulation of transforming growth factor beta2 production (GO:0032909)2.86731805
27nonmotile primary cilium assembly (GO:0035058)2.84975098
28paraxial mesoderm development (GO:0048339)2.83727835
29protein K6-linked ubiquitination (GO:0085020)2.83688155
30sequestering of extracellular ligand from receptor (GO:0035581)2.79006742
31biotin metabolic process (GO:0006768)2.78092853
32negative regulation of axon extension involved in axon guidance (GO:0048843)2.76274878
33body morphogenesis (GO:0010171)2.69334894
34collagen fibril organization (GO:0030199)2.67031048
35negative regulation of osteoblast proliferation (GO:0033689)2.65775808
36cell communication by electrical coupling (GO:0010644)2.64891570
37peptide hormone processing (GO:0016486)2.62308856
38kidney mesenchyme development (GO:0072074)2.61440189
39neuron recognition (GO:0008038)2.57459630
40exocrine pancreas development (GO:0031017)2.57018048
41pyrimidine nucleobase catabolic process (GO:0006208)2.55999582
42chondrocyte development (GO:0002063)2.55658499
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55524983
44endocardial cushion morphogenesis (GO:0003203)2.55221000
45cilium morphogenesis (GO:0060271)2.55179936
46insulin secretion (GO:0030073)2.53710363
47negative regulation of axon guidance (GO:1902668)2.53702230
48membrane repolarization during action potential (GO:0086011)2.53371906
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52506364
50regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52498684
51regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50609394
52dorsal/ventral axis specification (GO:0009950)2.50601963
53positive regulation of vesicle fusion (GO:0031340)2.48631232
54limb bud formation (GO:0060174)2.48014001
55negative regulation of insulin secretion (GO:0046676)2.47750318
56vesicle coating (GO:0006901)2.47727998
57mesenchyme morphogenesis (GO:0072132)2.47468689
58positive regulation of hormone biosynthetic process (GO:0046886)2.46499515
59iron ion import (GO:0097286)2.44303617
60cerebral cortex radially oriented cell migration (GO:0021799)2.42564821
61columnar/cuboidal epithelial cell development (GO:0002066)2.41646056
62endocrine pancreas development (GO:0031018)2.40680791
63epithelial cell fate commitment (GO:0072148)2.40428685
64negative regulation of cartilage development (GO:0061037)2.39137380
65positive regulation of nuclease activity (GO:0032075)2.38082548
66olfactory bulb development (GO:0021772)2.37864011
67L-serine transport (GO:0015825)2.37782393
68appendage development (GO:0048736)2.37504899
69limb development (GO:0060173)2.37504899
70inner ear receptor cell development (GO:0060119)2.37184076
71membrane repolarization (GO:0086009)2.37132155
72eye photoreceptor cell differentiation (GO:0001754)2.36981146
73photoreceptor cell differentiation (GO:0046530)2.36981146
74import into cell (GO:0098657)2.35744930
75convergent extension (GO:0060026)2.34835136
76innervation (GO:0060384)2.34164429
77muscle cell fate commitment (GO:0042693)2.33393445
78retinal ganglion cell axon guidance (GO:0031290)2.32789465
79response to nitrosative stress (GO:0051409)2.32027306
80urinary tract smooth muscle contraction (GO:0014848)2.31151807
81positive regulation of insulin secretion (GO:0032024)2.30848616
82negative regulation of protein localization to cell surface (GO:2000009)2.30817285
83calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.30635056
84nitric oxide mediated signal transduction (GO:0007263)2.29144284
85regulation of insulin secretion (GO:0050796)2.28961760
86chondrocyte proliferation (GO:0035988)2.28461320
87alanine transport (GO:0032328)2.27219733
88regulation of axon extension involved in axon guidance (GO:0048841)2.26215259
89somite development (GO:0061053)2.25823329
90spinal cord development (GO:0021510)2.25478026
91embryonic axis specification (GO:0000578)2.24882305
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.24788194
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24634097
94embryonic body morphogenesis (GO:0010172)2.24272065
95behavioral response to ethanol (GO:0048149)2.23548802
96negative regulation of peptide hormone secretion (GO:0090278)2.23170942
97regulation of male gonad development (GO:2000018)2.22330110
98lymphangiogenesis (GO:0001946)2.22098475
99negative regulation of catenin import into nucleus (GO:0035414)2.22064323
100regulation of penile erection (GO:0060405)2.21907650
101apical protein localization (GO:0045176)2.21496064
102positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20459065
103negative chemotaxis (GO:0050919)2.19618003
104insulin-like growth factor receptor signaling pathway (GO:0048009)2.19431630
105embryonic foregut morphogenesis (GO:0048617)2.18563358
106DNA double-strand break processing (GO:0000729)2.17938579
107response to pheromone (GO:0019236)2.17910155
108regulation of axon guidance (GO:1902667)2.17498795
109negative regulation of keratinocyte proliferation (GO:0010839)2.16924950
110regulation of tight junction assembly (GO:2000810)2.16623293
111mesoderm formation (GO:0001707)2.16598982
112cerebellar Purkinje cell layer development (GO:0021680)2.15896291
113dorsal/ventral pattern formation (GO:0009953)2.15716444
114regulation of membrane repolarization (GO:0060306)2.14963154
115hippo signaling (GO:0035329)2.14117230
116fibroblast migration (GO:0010761)2.13845940
117pharyngeal system development (GO:0060037)2.13619145
118asymmetric protein localization (GO:0008105)2.13288770
119regulation of hippo signaling (GO:0035330)2.13072807
120protein heterotrimerization (GO:0070208)2.12323082
121glandular epithelial cell differentiation (GO:0002067)2.11871703
122regulation of nuclease activity (GO:0032069)2.11145408
123astrocyte differentiation (GO:0048708)2.11049078
124sequestering of metal ion (GO:0051238)2.10814053
125cerebral cortex cell migration (GO:0021795)2.10626670
126gamma-aminobutyric acid transport (GO:0015812)2.09902188
127intraciliary transport (GO:0042073)2.09461708
128negative regulation of peptide secretion (GO:0002792)2.09365366
129cilium assembly (GO:0042384)2.07700293
130positive regulation of synapse assembly (GO:0051965)2.07670564
131embryonic pattern specification (GO:0009880)2.07627440
132smoothened signaling pathway (GO:0007224)2.07580792
133neurotransmitter catabolic process (GO:0042135)2.07577154
134regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.07382449
135positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.07365164
136ER overload response (GO:0006983)2.06798173
137regulation of female gonad development (GO:2000194)2.06775366
138cilium organization (GO:0044782)2.06358941
139branched-chain amino acid metabolic process (GO:0009081)2.05844456
140negative regulation of fatty acid transport (GO:2000192)2.05582892
141C4-dicarboxylate transport (GO:0015740)2.05504266
142cellular response to vitamin D (GO:0071305)2.05481678
143neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.05478817
144cholesterol biosynthetic process (GO:0006695)2.05393570
145negative regulation of oligodendrocyte differentiation (GO:0048715)2.05240775
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.05228634
147atrial cardiac muscle cell action potential (GO:0086014)2.04926642
148cartilage condensation (GO:0001502)2.04471513
149cell aggregation (GO:0098743)2.04471513
150detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.04342580
151positive regulation of mitochondrial fission (GO:0090141)2.04043942
152glial cell proliferation (GO:0014009)2.03996291
153endoplasmic reticulum unfolded protein response (GO:0030968)2.03909993
154growth hormone secretion (GO:0030252)2.02508293
155somite rostral/caudal axis specification (GO:0032525)2.02344401
156negative regulation of chondrocyte differentiation (GO:0032331)2.02305259
157detection of calcium ion (GO:0005513)2.00845333
158potassium ion export (GO:0071435)2.00807961
159glomerular basement membrane development (GO:0032836)2.00466833
160cellular response to unfolded protein (GO:0034620)2.00265439
161positive regulation of neuroblast proliferation (GO:0002052)1.99671932
162mesenchymal-epithelial cell signaling (GO:0060638)1.99527137
163dermatan sulfate biosynthetic process (GO:0030208)1.99253665
164embryonic digit morphogenesis (GO:0042733)1.99039421
165retinal cone cell development (GO:0046549)1.98126018
166regulation of timing of cell differentiation (GO:0048505)1.97813964
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.97323307
168positive regulation of male gonad development (GO:2000020)1.96364977
169ventricular septum morphogenesis (GO:0060412)1.95646314
170anterior/posterior axis specification (GO:0009948)1.94716201
171inner ear receptor stereocilium organization (GO:0060122)1.94670664
172regulation of synapse assembly (GO:0051963)1.94401549
173hair cell differentiation (GO:0035315)1.94105176
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.93216979
175toxin metabolic process (GO:0009404)1.92266588
176peptidyl-cysteine modification (GO:0018198)1.91089977
177outer ear morphogenesis (GO:0042473)1.91073323
178synapse assembly (GO:0007416)1.90503293
179sex differentiation (GO:0007548)1.90371281
180replicative senescence (GO:0090399)1.89492277
181dermatan sulfate metabolic process (GO:0030205)1.89313666
182regulation of development, heterochronic (GO:0040034)1.89277154
183serine family amino acid biosynthetic process (GO:0009070)1.89089364
184negative regulation of astrocyte differentiation (GO:0048712)1.89036577
185negative regulation of JUN kinase activity (GO:0043508)1.88821110
186nucleobase catabolic process (GO:0046113)1.88532746
187histone H2A acetylation (GO:0043968)1.88525179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86761752
2EZH2_22144423_ChIP-Seq_EOC_Human2.74947112
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.58687789
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43691003
5VDR_22108803_ChIP-Seq_LS180_Human2.39320063
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.39291986
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.37251342
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28703446
9EWS_26573619_Chip-Seq_HEK293_Human2.13415004
10GBX2_23144817_ChIP-Seq_PC3_Human2.12289221
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.04209660
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.99142871
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96470201
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.94024076
15TAF15_26573619_Chip-Seq_HEK293_Human1.92622730
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87776592
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87170011
18AR_21909140_ChIP-Seq_LNCAP_Human1.85948660
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85078301
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85078301
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83751453
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83271264
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81557422
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70721999
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70691219
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70579409
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70025626
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68914881
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67332047
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.64856151
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64723575
32* ISL1_27105846_Chip-Seq_CPCs_Mouse1.64487452
33* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64353567
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63943843
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62714113
36* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61265304
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60415309
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57025306
39* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56669399
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54841145
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.50996709
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49147824
43* STAT3_23295773_ChIP-Seq_U87_Human1.48484633
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48225687
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.47938758
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.47904552
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47659033
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46950753
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46524983
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45467147
51CLOCK_20551151_ChIP-Seq_293T_Human1.44806944
52RNF2_27304074_Chip-Seq_NSC_Mouse1.43037980
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42792047
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42780930
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40335409
56IGF1R_20145208_ChIP-Seq_DFB_Human1.39480196
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39354282
58AR_21572438_ChIP-Seq_LNCaP_Human1.38709248
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38079272
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37925861
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37498518
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.35300390
63BCAT_22108803_ChIP-Seq_LS180_Human1.34889411
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34494046
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34251260
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.34188898
67* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34143331
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33649534
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31872790
70ER_23166858_ChIP-Seq_MCF-7_Human1.31636436
71* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31046067
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31033043
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30015977
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29595824
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29395732
76* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27299390
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.26743332
78CJUN_26792858_Chip-Seq_BT549_Human1.26596352
79* EZH2_27294783_Chip-Seq_ESCs_Mouse1.25625710
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.23595728
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23423738
82CBP_20019798_ChIP-Seq_JUKART_Human1.23423738
83* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22726299
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21468028
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20153615
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20031703
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19803726
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19637982
89* AR_19668381_ChIP-Seq_PC3_Human1.19281835
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19207997
91* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18718244
92BRD4_25478319_ChIP-Seq_HGPS_Human1.18462417
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18019162
94TCF4_22108803_ChIP-Seq_LS180_Human1.16038768
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15788694
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15788694
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14654860
98* P300_19829295_ChIP-Seq_ESCs_Human1.14317740
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14176952
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13834860
101* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13572056
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12972103
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12652043
104* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12437814
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.12051915
106FUS_26573619_Chip-Seq_HEK293_Human1.12007013
107SOX9_26525672_Chip-Seq_HEART_Mouse1.10447115
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10027322
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09949720
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08857633
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06857938
112* JUN_21703547_ChIP-Seq_K562_Human1.06814310
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06405107
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05289306
115TCF4_23295773_ChIP-Seq_U87_Human1.04968977
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.04233083
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.03917679
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03458201
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03394680
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03301107
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.02995344
122TP53_18474530_ChIP-ChIP_U2OS_Human1.01382233
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01220846
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00736464
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00490604
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00427916
127DROSHA_22980978_ChIP-Seq_HELA_Human1.00082206
128AR_25329375_ChIP-Seq_VCAP_Human0.99422840
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99258334
130RXR_22108803_ChIP-Seq_LS180_Human0.98854592
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98634151
132* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97650967
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97430973
134* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96904938
135* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96117999
136* GF1B_26923725_Chip-Seq_HPCs_Mouse0.95970153
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.95881059
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95556015
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95481142
140* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95359619
141* RUNX2_22187159_ChIP-Seq_PCA_Human0.95140937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo2.99403273
2MP0002877_abnormal_melanocyte_morpholog2.86132076
3MP0003283_abnormal_digestive_organ2.66062288
4MP0008438_abnormal_cutaneous_collagen2.61981302
5MP0000013_abnormal_adipose_tissue2.44712076
6MP0005367_renal/urinary_system_phenotyp2.35277361
7MP0000516_abnormal_urinary_system2.35277361
8MP0004272_abnormal_basement_membrane2.25798061
9MP0000678_abnormal_parathyroid_gland2.08997008
10MP0010386_abnormal_urinary_bladder1.93765804
11MP0010030_abnormal_orbit_morphology1.93439443
12MP0002234_abnormal_pharynx_morphology1.93375077
13MP0003122_maternal_imprinting1.91099740
14MP0005503_abnormal_tendon_morphology1.86166744
15MP0006072_abnormal_retinal_apoptosis1.85333366
16MP0003123_paternal_imprinting1.80132627
17MP0005670_abnormal_white_adipose1.76769611
18MP0000003_abnormal_adipose_tissue1.76282807
19MP0005171_absent_coat_pigmentation1.68622090
20MP0000778_abnormal_nervous_system1.68054804
21MP0002909_abnormal_adrenal_gland1.66277686
22MP0004233_abnormal_muscle_weight1.65319039
23MP0003121_genomic_imprinting1.64542319
24MP0003011_delayed_dark_adaptation1.63532083
25MP0001299_abnormal_eye_distance/1.62902625
26MP0003942_abnormal_urinary_system1.60973554
27MP0002837_dystrophic_cardiac_calcinosis1.57868548
28MP0001944_abnormal_pancreas_morphology1.56096896
29MP0005379_endocrine/exocrine_gland_phen1.56063350
30MP0009384_cardiac_valve_regurgitation1.56028792
31MP0002102_abnormal_ear_morphology1.55160822
32MP0000049_abnormal_middle_ear1.54845413
33MP0005646_abnormal_pituitary_gland1.52654038
34MP0008789_abnormal_olfactory_epithelium1.51303141
35MP0000428_abnormal_craniofacial_morphol1.48769336
36MP0004043_abnormal_pH_regulation1.46437409
37MP0009250_abnormal_appendicular_skeleto1.40546464
38MP0005499_abnormal_olfactory_system1.40012024
39MP0005394_taste/olfaction_phenotype1.40012024
40MP0002896_abnormal_bone_mineralization1.38028417
41MP0005508_abnormal_skeleton_morphology1.36575182
42MP0003315_abnormal_perineum_morphology1.33507070
43MP0003705_abnormal_hypodermis_morpholog1.30611108
44MP0000163_abnormal_cartilage_morphology1.30131852
45MP0001984_abnormal_olfaction1.29937773
46MP0005275_abnormal_skin_tensile1.27419077
47MP0009053_abnormal_anal_canal1.27178660
48MP0005248_abnormal_Harderian_gland1.26808904
49MP0003136_yellow_coat_color1.26769269
50MP0000569_abnormal_digit_pigmentation1.26365658
51MP0003755_abnormal_palate_morphology1.25749583
52MP0001270_distended_abdomen1.25214363
53MP0000534_abnormal_ureter_morphology1.25184335
54MP0004858_abnormal_nervous_system1.23515697
55MP0000537_abnormal_urethra_morphology1.23175991
56MP0002653_abnormal_ependyma_morphology1.23052746
57MP0003119_abnormal_digestive_system1.22529891
58MP0003935_abnormal_craniofacial_develop1.22361962
59MP0003937_abnormal_limbs/digits/tail_de1.21076611
60MP0003787_abnormal_imprinting1.20545695
61MP0003890_abnormal_embryonic-extraembry1.19770485
62MP0005375_adipose_tissue_phenotype1.18806920
63MP0004145_abnormal_muscle_electrophysio1.18627534
64MP0003385_abnormal_body_wall1.18286845
65MP0003115_abnormal_respiratory_system1.15255833
66MP0002116_abnormal_craniofacial_bone1.15212922
67MP0001529_abnormal_vocalization1.14871896
68MP0004185_abnormal_adipocyte_glucose1.14039258
69MP0003279_aneurysm1.12261536
70MP0005666_abnormal_adipose_tissue1.11743547
71MP0001485_abnormal_pinna_reflex1.11521311
72MP0006292_abnormal_olfactory_placode1.10484463
73MP0002638_abnormal_pupillary_reflex1.09815656
74MP0002736_abnormal_nociception_after1.07916765
75MP0002249_abnormal_larynx_morphology1.07663723
76MP0000631_abnormal_neuroendocrine_gland1.06736027
77MP0002693_abnormal_pancreas_physiology1.04984587
78MP0000372_irregular_coat_pigmentation1.04709824
79MP0004133_heterotaxia1.03338542
80MP0005220_abnormal_exocrine_pancreas1.01723854
81MP0002233_abnormal_nose_morphology1.01274809
82MP0010368_abnormal_lymphatic_system1.01174276
83MP0000538_abnormal_urinary_bladder0.99560439
84MP0000026_abnormal_inner_ear0.99092171
85MP0000566_synostosis0.98846365
86MP0005253_abnormal_eye_physiology0.97564401
87MP0006054_spinal_hemorrhage0.95888304
88MP0002822_catalepsy0.94547319
89MP0002108_abnormal_muscle_morphology0.93928691
90MP0001177_atelectasis0.93233250
91MP0002090_abnormal_vision0.92881790
92MP0005187_abnormal_penis_morphology0.91666392
93MP0002282_abnormal_trachea_morphology0.90917409
94MP0002751_abnormal_autonomic_nervous0.90875742
95MP0002557_abnormal_social/conspecific_i0.90642933
96MP0004270_analgesia0.90610806
97MP0002115_abnormal_skeleton_extremities0.90549183
98MP0005257_abnormal_intraocular_pressure0.90224425
99MP0002295_abnormal_pulmonary_circulatio0.89131019
100MP0002177_abnormal_outer_ear0.89014121
101MP0000955_abnormal_spinal_cord0.87996051
102MP0004134_abnormal_chest_morphology0.87866579
103MP0001486_abnormal_startle_reflex0.87361647
104MP0003183_abnormal_peptide_metabolism0.86583931
105MP0003950_abnormal_plasma_membrane0.85498848
106MP0005551_abnormal_eye_electrophysiolog0.85211158
107MP0002184_abnormal_innervation0.84736019
108MP0001879_abnormal_lymphatic_vessel0.84484839
109MP0003880_abnormal_central_pattern0.83945033
110MP0001293_anophthalmia0.83790160
111MP0003941_abnormal_skin_development0.82983956
112MP0002734_abnormal_mechanical_nocicepti0.82459945
113MP0000462_abnormal_digestive_system0.81882107
114MP0001286_abnormal_eye_development0.81519961
115MP0004215_abnormal_myocardial_fiber0.81337667
116MP0002109_abnormal_limb_morphology0.81235367
117MP0000427_abnormal_hair_cycle0.81107274
118MP0005391_vision/eye_phenotype0.80724238
119MP0002752_abnormal_somatic_nervous0.80189059
120MP0001968_abnormal_touch/_nociception0.80055769
121MP0003861_abnormal_nervous_system0.80050378
122MP0002938_white_spotting0.79903120
123MP0000432_abnormal_head_morphology0.79053844
124MP0003938_abnormal_ear_development0.79002091
125MP0002127_abnormal_cardiovascular_syste0.77749300
126MP0002697_abnormal_eye_size0.76761711
127MP0000613_abnormal_salivary_gland0.76618914
128MP0000639_abnormal_adrenal_gland0.76256257
129MP0002160_abnormal_reproductive_system0.76203901
130MP0002078_abnormal_glucose_homeostasis0.75600893
131MP0004084_abnormal_cardiac_muscle0.75394978
132MP0003567_abnormal_fetal_cardiomyocyte0.75028722
133MP0001986_abnormal_taste_sensitivity0.74079796
134MP0002163_abnormal_gland_morphology0.73952043
135MP0005623_abnormal_meninges_morphology0.73364457
136MP0002932_abnormal_joint_morphology0.73288851
137MP0002168_other_aberrant_phenotype0.70274266
138MP0003646_muscle_fatigue0.69459806
139MP0006138_congestive_heart_failure0.69187022
140MP0001958_emphysema0.68761810

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)3.18328675
2Abnormality of the ischium (HP:0003174)3.16694401
3Hyperinsulinemic hypoglycemia (HP:0000825)3.12212567
4Hypoplastic ischia (HP:0003175)3.06477017
5Hypoglycemic seizures (HP:0002173)2.90860957
6True hermaphroditism (HP:0010459)2.82271593
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.80460407
8Premature rupture of membranes (HP:0001788)2.77806488
9Protrusio acetabuli (HP:0003179)2.73424329
10Hepatoblastoma (HP:0002884)2.72661439
11Flat capital femoral epiphysis (HP:0003370)2.71089358
12Insulin-resistant diabetes mellitus (HP:0000831)2.70525075
13Pancreatic fibrosis (HP:0100732)2.69975026
14Medial flaring of the eyebrow (HP:0010747)2.53401757
15Abnormality of midbrain morphology (HP:0002418)2.51951893
16Molar tooth sign on MRI (HP:0002419)2.51951893
17Symptomatic seizures (HP:0011145)2.51112214
18Hypoglycemic coma (HP:0001325)2.50489281
19Hyperglycemia (HP:0003074)2.50076784
20Pancreatic cysts (HP:0001737)2.49213365
21Hyperventilation (HP:0002883)2.49086367
22Papillary thyroid carcinoma (HP:0002895)2.47338760
23Megalencephaly (HP:0001355)2.46205947
24Large for gestational age (HP:0001520)2.44988604
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44800511
26Nephronophthisis (HP:0000090)2.39669501
27Gait imbalance (HP:0002141)2.38681098
28Epiphyseal dysplasia (HP:0002656)2.36687096
29Congenital primary aphakia (HP:0007707)2.35921380
30Aplasia involving bones of the extremities (HP:0009825)2.34772055
31Aplasia involving bones of the upper limbs (HP:0009823)2.34772055
32Aplasia of the phalanges of the hand (HP:0009802)2.34772055
33Neonatal short-limb short stature (HP:0008921)2.33751989
34Arterial tortuosity (HP:0005116)2.33429077
35Abnormality of the labia minora (HP:0012880)2.32215353
36Shawl scrotum (HP:0000049)2.31169700
37Gonadotropin excess (HP:0000837)2.29664873
38Broad long bones (HP:0005622)2.27669791
39Shallow orbits (HP:0000586)2.27336825
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.25530733
41Aplasia of the musculature (HP:0100854)2.24264190
42Broad thumb (HP:0011304)2.21724461
43Vascular tortuosity (HP:0004948)2.21600700
44Abnormality of dentin (HP:0010299)2.21524169
45Absent eyebrow (HP:0002223)2.18334431
46Abnormality of the axillary hair (HP:0100134)2.17931748
47Abnormality of secondary sexual hair (HP:0009888)2.17931748
48Drooling (HP:0002307)2.16565006
49Broad phalanx (HP:0006009)2.14911669
50Tracheomalacia (HP:0002779)2.14055529
51Postaxial hand polydactyly (HP:0001162)2.13786492
52Soft skin (HP:0000977)2.11228107
53Nephrogenic diabetes insipidus (HP:0009806)2.11146030
54Abnormal pancreas size (HP:0012094)2.07454952
55Popliteal pterygium (HP:0009756)2.06408466
56Chronic hepatic failure (HP:0100626)2.05769464
57Bronchomalacia (HP:0002780)2.05121714
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.04877125
59Genital tract atresia (HP:0001827)2.03792014
60Cervical subluxation (HP:0003308)2.02122567
61Fibular hypoplasia (HP:0003038)2.02024649
62Vaginal atresia (HP:0000148)1.98963542
63Poor coordination (HP:0002370)1.97535593
64Bladder diverticulum (HP:0000015)1.96489437
65Overgrowth (HP:0001548)1.96311762
66Aortic dissection (HP:0002647)1.96148837
67Aplasia/Hypoplasia of the fovea (HP:0008060)1.95976654
68Hypoplasia of the fovea (HP:0007750)1.95976654
69Follicular hyperkeratosis (HP:0007502)1.94891024
70Calf muscle hypertrophy (HP:0008981)1.94708207
71Micropenis (HP:0000054)1.93577838
72Broad phalanges of the hand (HP:0009768)1.92585176
73Abnormality of the renal medulla (HP:0100957)1.92404576
74Bifid tongue (HP:0010297)1.92061415
75Exostoses (HP:0100777)1.92044057
76Abnormality of the astrocytes (HP:0100707)1.91718839
77Astrocytoma (HP:0009592)1.91718839
78Broad finger (HP:0001500)1.91023119
79Abnormality of the fovea (HP:0000493)1.90758673
80Postaxial foot polydactyly (HP:0001830)1.90240966
81Keratoconus (HP:0000563)1.88445420
82Increased corneal curvature (HP:0100692)1.88445420
83Thoracolumbar scoliosis (HP:0002944)1.87496515
84Hypoplastic labia majora (HP:0000059)1.87222753
85Sclerocornea (HP:0000647)1.85976726
86Tented upper lip vermilion (HP:0010804)1.85847525
87Hypothermia (HP:0002045)1.85557708
88Abnormality of the proximal phalanges of the hand (HP:0009834)1.83764553
89Type II lissencephaly (HP:0007260)1.82148159
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.81780163
91Bell-shaped thorax (HP:0001591)1.81573199
92Excessive salivation (HP:0003781)1.80819883
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.80589051
94Hypokalemia (HP:0002900)1.80249709
95Patent foramen ovale (HP:0001655)1.79898487
96Coronal craniosynostosis (HP:0004440)1.79113827
97Chorioretinal atrophy (HP:0000533)1.78382918
98Narrow forehead (HP:0000341)1.78114456
99Congenital glaucoma (HP:0001087)1.77617263
100Abnormality of the pubic bones (HP:0003172)1.76526903
101Broad foot (HP:0001769)1.76482079
102Occipital encephalocele (HP:0002085)1.75705661
103Missing ribs (HP:0000921)1.74863350
104Ketoacidosis (HP:0001993)1.74842570
105Short 1st metacarpal (HP:0010034)1.73718748
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73718748
107Short nail (HP:0001799)1.73582741
108Retinal dysplasia (HP:0007973)1.72840802
109Small hand (HP:0200055)1.72366291
110Male pseudohermaphroditism (HP:0000037)1.71792636
111Hyperextensible skin (HP:0000974)1.70979210
112Hyperglycinemia (HP:0002154)1.70809976
113Specific learning disability (HP:0001328)1.70139074
114Midline defect of the nose (HP:0004122)1.70059016
115Absent speech (HP:0001344)1.68605052
116Sparse lateral eyebrow (HP:0005338)1.68294833
117Absent eyelashes (HP:0000561)1.67503748
118Decreased testicular size (HP:0008734)1.67307293
119Anencephaly (HP:0002323)1.67201177
120Renal duplication (HP:0000075)1.66375873
121Buphthalmos (HP:0000557)1.66059642
122Mesomelia (HP:0003027)1.65507673
123Lissencephaly (HP:0001339)1.64910346
124Abnormality of the labia majora (HP:0012881)1.64785111
125Irregular epiphyses (HP:0010582)1.64095248
126Short tibia (HP:0005736)1.63710918
127Abnormality of serine family amino acid metabolism (HP:0010894)1.63495392
128Abnormality of glycine metabolism (HP:0010895)1.63495392
129Muscle hypertrophy of the lower extremities (HP:0008968)1.62947260
130Ankle contracture (HP:0006466)1.62160388
131Short foot (HP:0001773)1.61999615
132Glioma (HP:0009733)1.61462349
133Osteoarthritis (HP:0002758)1.61085814
134Pancreatic islet-cell hyperplasia (HP:0004510)1.61036316
135Hyperglycinuria (HP:0003108)1.60882636
136Broad toe (HP:0001837)1.60337192
137Cutaneous finger syndactyly (HP:0010554)1.59583283
138Thin ribs (HP:0000883)1.59392464
139Dyskinesia (HP:0100660)1.59226319
140Joint laxity (HP:0001388)1.58985241
141Rectal prolapse (HP:0002035)1.58808188
142Renal dysplasia (HP:0000110)1.57742968
143Aortic aneurysm (HP:0004942)1.57614591
144Pterygium (HP:0001059)1.57606549
145Congenital stationary night blindness (HP:0007642)1.57403315
146Bifid scrotum (HP:0000048)1.56925270
147Morphological abnormality of the middle ear (HP:0008609)1.56744878
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.56660380
149Abnormality of incisor morphology (HP:0011063)1.55741613
150Aplasia/Hypoplasia of the lens (HP:0008063)1.55509804
151Spinal rigidity (HP:0003306)1.55441900
152Optic nerve hypoplasia (HP:0000609)1.54968108
153Pachygyria (HP:0001302)1.54644284
154Turricephaly (HP:0000262)1.54175928
155Abnormality of potassium homeostasis (HP:0011042)1.53935079
156Cerebral aneurysm (HP:0004944)1.53857353
157Intestinal atresia (HP:0011100)1.53104613
158Volvulus (HP:0002580)1.52786521
159Cutaneous syndactyly (HP:0012725)1.52766859
160Hemiparesis (HP:0001269)1.52134666
161Hypoplasia of the ulna (HP:0003022)1.52058933
162Wide anterior fontanel (HP:0000260)1.51648085
163Renal hypoplasia (HP:0000089)1.51486602
164Abnormality of the 1st metacarpal (HP:0010009)1.51336486
165Infantile muscular hypotonia (HP:0008947)1.51214908
166Thyroid carcinoma (HP:0002890)1.50315398
167Ependymoma (HP:0002888)1.49116523
168Truncal obesity (HP:0001956)1.48989787
169Short 4th metacarpal (HP:0010044)1.48951344
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.48951344
171Aneurysm (HP:0002617)1.48708834
172Aplasia/Hypoplasia of the ulna (HP:0006495)1.48251788
173Mitral valve prolapse (HP:0001634)1.48118231
174Septo-optic dysplasia (HP:0100842)1.47615810
175Preaxial foot polydactyly (HP:0001841)1.46854305
176Astigmatism (HP:0000483)1.46735821
177Aganglionic megacolon (HP:0002251)1.45912774
178Increased number of teeth (HP:0011069)1.45854473
179Decreased circulating renin level (HP:0003351)1.44443160
180Cystic liver disease (HP:0006706)1.44348337
181Disproportionate short-trunk short stature (HP:0003521)1.42897532
182Broad metatarsal (HP:0001783)1.42686449
183Protuberant abdomen (HP:0001538)1.40641721
184Dilatation of the ascending aorta (HP:0005111)1.40251313
185Micromelia (HP:0002983)1.40011714
186Abnormality of endocrine pancreas physiology (HP:0012093)1.39412218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.81379772
2STK38L3.79904875
3INSRR3.74149334
4LATS22.97173174
5CASK2.75044146
6TRIB32.59273714
7GRK12.58959956
8PNCK2.52167842
9PDGFRA2.27771858
10MAP4K22.13975530
11STK392.06981577
12LMTK22.05773388
13DDR22.02306512
14FRK1.90093609
15MAP3K21.83471239
16SGK21.83095009
17PASK1.78704105
18TRIM281.76800224
19AKT31.69046313
20MARK11.68182897
21FER1.67522465
22NEK91.65244293
23MUSK1.62831366
24CDC42BPA1.56218519
25SGK2231.52266582
26SGK4941.52266582
27CAMK1D1.50445469
28PKN21.47850794
29WEE11.45314035
30EPHB21.39461064
31* MAPK131.38066305
32CDK81.33203221
33SGK31.33169020
34KSR21.32843927
35PAK31.30742847
36NTRK11.29321267
37CAMK1G1.28560513
38NTRK31.28246421
39HIPK21.26407141
40PHKG11.22578672
41PHKG21.22578672
42WNK41.22475458
43* PRKD31.20825339
44TNK21.17212104
45ERBB31.13412508
46MAP3K41.12794163
47CSNK1A1L1.12590058
48TAF11.12420320
49STK381.09699649
50MAP3K61.09543425
51CSNK1G11.06599779
52WNK31.06439219
53KSR11.04046883
54SIK11.03341075
55CSNK1G21.03028987
56STK31.00577268
57CCNB10.99158213
58CDK90.95592317
59NEK10.94171585
60MELK0.93912101
61ACVR1B0.93057409
62MYLK0.92182878
63CSNK1G30.92013492
64RET0.90301219
65PRKAA10.90220278
66EIF2AK10.87968039
67PTK20.87754790
68EIF2AK30.87584898
69CAMKK20.87387316
70TGFBR10.83853699
71FLT30.83209051
72WNK10.82679016
73TYRO30.82166976
74PAK60.81513476
75OBSCN0.79841020
76PAK20.78106440
77ADRBK20.77443427
78DMPK0.76222563
79LIMK10.75540589
80PRKAA20.75360656
81MTOR0.72646061
82PLK20.72261465
83NEK60.70805985
84BRSK20.70753132
85DYRK20.70138374
86PRKCG0.69516524
87FGFR20.68576385
88BMPR20.68287201
89PIK3CA0.68035023
90SCYL20.67217683
91ROCK10.66571016
92PDGFRB0.66393835
93PLK40.66271732
94MAP2K10.64809386
95MKNK10.64368903
96BCKDK0.61502797
97MAP2K70.60688789
98FGFR10.60528320
99TAOK30.58947669
100BRAF0.58767819
101ERBB40.58522091
102MET0.58513167
103BRSK10.58183423
104PKN10.57757639
105NTRK20.57477096
106BRD40.57390450
107PDK30.57080615
108PDK40.57080615
109MAPK150.56796327
110MINK10.56634859
111FGFR30.55836165
112EPHA30.55096346
113VRK20.55063669
114RIPK10.54658293
115SGK10.54137047
116PLK30.52484233
117* PRKCH0.52077782
118ROCK20.52074564
119PTK60.51206260
120MAPKAPK30.50977111
121* PRKD20.47676194
122PINK10.46759707
123TNIK0.46395956
124CDK30.46215030
125NLK0.45807553
126TIE10.45217061
127CDK70.45171763
128ZAK0.44730981
129BMPR1B0.44439629
130DYRK1A0.44118386
131VRK10.44014302
132UHMK10.43651745
133ILK0.42633978
134ADRBK10.42094065
135EPHA40.41975726
136PBK0.41893597
137TSSK60.41888837
138BCR0.41683691
139* PRKCE0.41262099
140MARK30.40447308
141MAPK100.40376535
142OXSR10.39942917
143CSNK1A10.39839120
144TTK0.39651030
145MKNK20.39144061
146RPS6KA20.38924542
147CDK120.38638280
148NUAK10.37390347
149* AKT10.37119102
150MAPK140.36409310
151MAP3K10.36376847
152DYRK30.34108455
153* ATM0.33267916

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.53877380
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77978873
3Propanoate metabolism_Homo sapiens_hsa006402.55037378
4Insulin secretion_Homo sapiens_hsa049112.52102257
5Protein export_Homo sapiens_hsa030602.50335724
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28762558
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10785590
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95277734
9Steroid biosynthesis_Homo sapiens_hsa001001.87774146
10Butanoate metabolism_Homo sapiens_hsa006501.86089045
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84052474
12Circadian rhythm_Homo sapiens_hsa047101.78077215
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74577309
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68142463
15Selenocompound metabolism_Homo sapiens_hsa004501.65622404
16Basal transcription factors_Homo sapiens_hsa030221.61424599
17Sulfur metabolism_Homo sapiens_hsa009201.61166894
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55330063
19Glucagon signaling pathway_Homo sapiens_hsa049221.52128466
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49904580
21ECM-receptor interaction_Homo sapiens_hsa045121.48625446
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43544996
23Adherens junction_Homo sapiens_hsa045201.41706648
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41011987
25Phototransduction_Homo sapiens_hsa047441.40414708
26Hippo signaling pathway_Homo sapiens_hsa043901.39517482
27Protein digestion and absorption_Homo sapiens_hsa049741.36932970
28Fanconi anemia pathway_Homo sapiens_hsa034601.36265769
29TGF-beta signaling pathway_Homo sapiens_hsa043501.36241762
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36169651
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35974141
32Type II diabetes mellitus_Homo sapiens_hsa049301.34093485
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33303865
34beta-Alanine metabolism_Homo sapiens_hsa004101.31353769
35Arginine and proline metabolism_Homo sapiens_hsa003301.30938028
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30688201
37Melanogenesis_Homo sapiens_hsa049161.30212415
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29353218
39Cocaine addiction_Homo sapiens_hsa050301.27542017
40Dorso-ventral axis formation_Homo sapiens_hsa043201.24922191
41Focal adhesion_Homo sapiens_hsa045101.23580706
42Nicotine addiction_Homo sapiens_hsa050331.22705964
43Long-term potentiation_Homo sapiens_hsa047201.21317385
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21256890
45Dilated cardiomyopathy_Homo sapiens_hsa054141.21182758
46Hedgehog signaling pathway_Homo sapiens_hsa043401.21084661
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18509844
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.18160304
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17849919
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17728242
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17427120
52Basal cell carcinoma_Homo sapiens_hsa052171.16634129
53Histidine metabolism_Homo sapiens_hsa003401.15864262
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15576799
55Pyruvate metabolism_Homo sapiens_hsa006201.14906636
56Circadian entrainment_Homo sapiens_hsa047131.14654223
57Dopaminergic synapse_Homo sapiens_hsa047281.13914748
58mTOR signaling pathway_Homo sapiens_hsa041501.13844978
59Ovarian steroidogenesis_Homo sapiens_hsa049131.13071326
60Tryptophan metabolism_Homo sapiens_hsa003801.12678279
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11602382
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10814615
63Endometrial cancer_Homo sapiens_hsa052131.09937175
64Wnt signaling pathway_Homo sapiens_hsa043101.08800864
65Insulin resistance_Homo sapiens_hsa049311.08144704
66Thyroid hormone synthesis_Homo sapiens_hsa049181.08122004
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05945989
68Cholinergic synapse_Homo sapiens_hsa047251.04129706
69Insulin signaling pathway_Homo sapiens_hsa049101.03390306
70Estrogen signaling pathway_Homo sapiens_hsa049151.01666359
71AMPK signaling pathway_Homo sapiens_hsa041521.01376043
72Glioma_Homo sapiens_hsa052141.01356887
73Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01278118
74Fatty acid biosynthesis_Homo sapiens_hsa000611.01104419
75Amphetamine addiction_Homo sapiens_hsa050311.01025118
76Peroxisome_Homo sapiens_hsa041461.00732734
77Melanoma_Homo sapiens_hsa052180.99152644
78Lysine degradation_Homo sapiens_hsa003100.99005956
79* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98701006
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98656156
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98593663
82Bladder cancer_Homo sapiens_hsa052190.97871541
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97853589
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97715235
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97705704
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.97664821
87Thyroid cancer_Homo sapiens_hsa052160.96976456
88GABAergic synapse_Homo sapiens_hsa047270.96972880
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95664908
90Tight junction_Homo sapiens_hsa045300.94833085
91Mineral absorption_Homo sapiens_hsa049780.92154332
92Vitamin B6 metabolism_Homo sapiens_hsa007500.91982677
93Prostate cancer_Homo sapiens_hsa052150.91979443
94Vitamin digestion and absorption_Homo sapiens_hsa049770.91771243
95cAMP signaling pathway_Homo sapiens_hsa040240.91189869
96Renin secretion_Homo sapiens_hsa049240.91160880
97Taste transduction_Homo sapiens_hsa047420.90556043
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89824017
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87585290
100N-Glycan biosynthesis_Homo sapiens_hsa005100.86987611
101Proteoglycans in cancer_Homo sapiens_hsa052050.86269205
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.84832774
103GnRH signaling pathway_Homo sapiens_hsa049120.84722549
104Morphine addiction_Homo sapiens_hsa050320.83941742
105Serotonergic synapse_Homo sapiens_hsa047260.82623179
106Oocyte meiosis_Homo sapiens_hsa041140.82329784
107Gap junction_Homo sapiens_hsa045400.81285650
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80823974
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80255977
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79925128
111Fatty acid degradation_Homo sapiens_hsa000710.79345704
112Pancreatic secretion_Homo sapiens_hsa049720.77127173
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77007620
114Fatty acid elongation_Homo sapiens_hsa000620.76383882
115Glutamatergic synapse_Homo sapiens_hsa047240.75534308
116Renal cell carcinoma_Homo sapiens_hsa052110.74972059
117Vibrio cholerae infection_Homo sapiens_hsa051100.74563111
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73181327
119MicroRNAs in cancer_Homo sapiens_hsa052060.73009502
120Colorectal cancer_Homo sapiens_hsa052100.72886322
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71622812
122Ether lipid metabolism_Homo sapiens_hsa005650.70413243
123Fatty acid metabolism_Homo sapiens_hsa012120.70261535
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69779302
125Prolactin signaling pathway_Homo sapiens_hsa049170.69727514
126Gastric acid secretion_Homo sapiens_hsa049710.69165821
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.67132716
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66506591
129Olfactory transduction_Homo sapiens_hsa047400.65938601
130Pancreatic cancer_Homo sapiens_hsa052120.65332792
131Linoleic acid metabolism_Homo sapiens_hsa005910.65012055
132FoxO signaling pathway_Homo sapiens_hsa040680.64788740
133Nucleotide excision repair_Homo sapiens_hsa034200.64491569
134Axon guidance_Homo sapiens_hsa043600.62943799
135Non-homologous end-joining_Homo sapiens_hsa034500.60784301
136Salivary secretion_Homo sapiens_hsa049700.60610580
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60096757
138ErbB signaling pathway_Homo sapiens_hsa040120.60044527
139Oxytocin signaling pathway_Homo sapiens_hsa049210.59095815
140Long-term depression_Homo sapiens_hsa047300.58974271
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.57086071
142Cell cycle_Homo sapiens_hsa041100.56902828
143Ras signaling pathway_Homo sapiens_hsa040140.56459082
144RNA degradation_Homo sapiens_hsa030180.53654423
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53522710
146Galactose metabolism_Homo sapiens_hsa000520.52349145
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.49510143
148RNA polymerase_Homo sapiens_hsa030200.49389690
149One carbon pool by folate_Homo sapiens_hsa006700.49123017
150Folate biosynthesis_Homo sapiens_hsa007900.48917673
151Metabolic pathways_Homo sapiens_hsa011000.48750590
152Homologous recombination_Homo sapiens_hsa034400.48016485
153p53 signaling pathway_Homo sapiens_hsa041150.42965420
154Retinol metabolism_Homo sapiens_hsa008300.40577659
155Nitrogen metabolism_Homo sapiens_hsa009100.39729549

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