PRKCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.09040049
2neutrophil activation involved in immune response (GO:0002283)5.66904057
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.54813247
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.54813247
5modulation by symbiont of host immune response (GO:0052553)5.54813247
6positive regulation by symbiont of host defense response (GO:0052509)5.54813247
7modulation by symbiont of host defense response (GO:0052031)5.54813247
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.54813247
9response to peptidoglycan (GO:0032494)5.15923976
10respiratory burst (GO:0045730)4.80912382
11detection of other organism (GO:0098543)4.70173728
12regulation of interferon-beta biosynthetic process (GO:0045357)4.63632378
13macrophage activation involved in immune response (GO:0002281)4.62353177
14detection of bacterium (GO:0016045)4.55453562
15positive regulation of gamma-delta T cell activation (GO:0046645)4.37299755
16positive regulation of interferon-alpha production (GO:0032727)4.23155500
17* immunoglobulin mediated immune response (GO:0016064)4.04818593
18response to muramyl dipeptide (GO:0032495)4.02379258
19regulation of interferon-alpha production (GO:0032647)3.99917447
20detection of external biotic stimulus (GO:0098581)3.96725871
21antigen processing and presentation of endogenous antigen (GO:0019883)3.95517135
22leukocyte aggregation (GO:0070486)3.87098590
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85474434
24response to host immune response (GO:0052572)3.85474434
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.85127094
26* granulocyte activation (GO:0036230)3.83610057
27* neutrophil activation (GO:0042119)3.81618755
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80722032
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80722032
30hydrogen peroxide biosynthetic process (GO:0050665)3.78516255
31myeloid cell activation involved in immune response (GO:0002275)3.72896094
32positive regulation of B cell differentiation (GO:0045579)3.70391930
33regulation of B cell receptor signaling pathway (GO:0050855)3.63388435
34natural killer cell mediated cytotoxicity (GO:0042267)3.61258995
35natural killer cell mediated immunity (GO:0002228)3.61258995
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.59008370
37positive regulation of mast cell degranulation (GO:0043306)3.59008370
38production of molecular mediator involved in inflammatory response (GO:0002532)3.56776295
39negative regulation of erythrocyte differentiation (GO:0045647)3.55729824
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.54701756
41positive regulation of mast cell activation (GO:0033005)3.52059085
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.51357114
43positive regulation of antigen processing and presentation (GO:0002579)3.51178761
44neutrophil mediated immunity (GO:0002446)3.51166911
45reactive oxygen species biosynthetic process (GO:1903409)3.50886278
46detection of biotic stimulus (GO:0009595)3.48533021
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.47179501
48response to host (GO:0075136)3.47179501
49response to host defenses (GO:0052200)3.47179501
50cellular extravasation (GO:0045123)3.45890300
51regulation of mast cell degranulation (GO:0043304)3.44472430
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.42807426
53negative regulation of interleukin-12 production (GO:0032695)3.40140890
54superoxide anion generation (GO:0042554)3.39655159
55leukocyte mediated cytotoxicity (GO:0001909)3.37556353
56defense response to protozoan (GO:0042832)3.37348956
57cellular response to zinc ion (GO:0071294)3.37028637
58response to type I interferon (GO:0034340)3.36305913
59* interferon-gamma-mediated signaling pathway (GO:0060333)3.35297235
60cellular response to type I interferon (GO:0071357)3.34950024
61type I interferon signaling pathway (GO:0060337)3.34950024
62regulation of B cell differentiation (GO:0045577)3.34800977
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32398596
64microglial cell activation (GO:0001774)3.31561978
65positive regulation of interferon-beta production (GO:0032728)3.27567300
66macrophage activation (GO:0042116)3.23368551
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21772686
68negative regulation of leukocyte mediated immunity (GO:0002704)3.21145525
69NIK/NF-kappaB signaling (GO:0038061)3.19780190
70regulation of mast cell activation involved in immune response (GO:0033006)3.19618646
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19436473
72negative regulation of T cell mediated immunity (GO:0002710)3.18328404
73regulation of mast cell activation (GO:0033003)3.18123257
74positive regulation of chemokine biosynthetic process (GO:0045080)3.17539375
75regulation of T-helper 2 cell differentiation (GO:0045628)3.16052395
76leukocyte migration involved in inflammatory response (GO:0002523)3.14864823
77negative regulation of interleukin-17 production (GO:0032700)3.08260513
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07287806
79B cell receptor signaling pathway (GO:0050853)3.06761198
80antigen processing and presentation via MHC class Ib (GO:0002475)3.05466898
81positive regulation of leukocyte degranulation (GO:0043302)3.05360111
82Arp2/3 complex-mediated actin nucleation (GO:0034314)3.02535069
83response to protozoan (GO:0001562)3.02283728
84leukocyte cell-cell adhesion (GO:0007159)3.01185852
85regulation of tolerance induction (GO:0002643)3.01016301
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96736675
87negative regulation of cell killing (GO:0031342)2.96736675
88regulation of antigen processing and presentation (GO:0002577)2.96657746
89regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95663270
90regulation of T cell tolerance induction (GO:0002664)2.95609724
91regulation of leukocyte degranulation (GO:0043300)2.95376329
92negative regulation of cytokine production involved in immune response (GO:0002719)2.95144096
93regulation of gamma-delta T cell activation (GO:0046643)2.94505046
94myeloid dendritic cell activation (GO:0001773)2.93334156
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91460341
96positive regulation of type 2 immune response (GO:0002830)2.91381995
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.91282612
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89276697
99myeloid dendritic cell differentiation (GO:0043011)2.89219133
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88747118
101regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88508151
102neutrophil chemotaxis (GO:0030593)2.88409933
103* B cell mediated immunity (GO:0019724)2.85772444
104* myeloid leukocyte activation (GO:0002274)2.82539512
105negative regulation of innate immune response (GO:0045824)2.82027016
106detection of molecule of bacterial origin (GO:0032490)2.81944664
107neutrophil migration (GO:1990266)2.81269734
108response to interleukin-15 (GO:0070672)2.80947491
109response to interferon-alpha (GO:0035455)2.80834252
110negative regulation of toll-like receptor signaling pathway (GO:0034122)2.79321086
111leukocyte degranulation (GO:0043299)2.78862739
112regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78718504
113I-kappaB phosphorylation (GO:0007252)2.77333039
114myeloid leukocyte mediated immunity (GO:0002444)2.76765527
115regulation of regulated secretory pathway (GO:1903305)2.76541419
116negative regulation of interleukin-6 production (GO:0032715)2.76000192
117regulation of chemokine biosynthetic process (GO:0045073)2.75523315
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.75479677
119tolerance induction (GO:0002507)2.75470237
120cytokine secretion (GO:0050663)2.73837169
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73686066
122germinal center formation (GO:0002467)2.72435170
123positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72313304
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.71196887
125response to fungus (GO:0009620)2.71104347
126regulation of gamma-delta T cell differentiation (GO:0045586)2.71063736
127regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69740325
128T-helper 1 type immune response (GO:0042088)2.68859756
129regulation of type 2 immune response (GO:0002828)2.67513457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.93762939
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.86242063
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.09892222
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.08294730
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.87897412
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64159693
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61166664
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58382257
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.36531750
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26078661
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.20847856
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20793801
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.12984113
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01870312
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78519511
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66672552
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47889053
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40006526
19* SPI1_23547873_ChIP-Seq_NB4_Human2.38214648
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37875381
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36874398
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33180277
23SCL_19346495_ChIP-Seq_HPC-7_Human2.30116936
24* VDR_21846776_ChIP-Seq_THP-1_Human2.16913290
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13378979
26* VDR_24763502_ChIP-Seq_THP-1_Human2.10188939
27MYB_26560356_Chip-Seq_TH2_Human2.02009924
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.00039416
29SPI1_23127762_ChIP-Seq_K562_Human1.98915652
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.95850633
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94668110
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.91402601
33* MAF_26560356_Chip-Seq_TH1_Human1.88675823
34RUNX_20019798_ChIP-Seq_JUKART_Human1.85431971
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82478202
36MYB_26560356_Chip-Seq_TH1_Human1.71329186
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71316417
38* PU_27001747_Chip-Seq_BMDM_Mouse1.68788261
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64664310
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60991570
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60817341
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58824035
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57904500
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.50006493
45UTX_26944678_Chip-Seq_JUKART_Human1.49526507
46MYC_22102868_ChIP-Seq_BL_Human1.49473356
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48169876
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47574516
49VDR_24787735_ChIP-Seq_THP-1_Human1.45413615
50GATA1_22025678_ChIP-Seq_K562_Human1.44223227
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42724511
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41763006
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36744227
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34973905
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34051097
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33304705
57GATA3_27048872_Chip-Seq_THYMUS_Human1.30230617
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29231239
59* RACK7_27058665_Chip-Seq_MCF-7_Human1.27785524
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27643834
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25733122
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25037263
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24889682
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24022145
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.23476937
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19281095
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18229609
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17805321
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17425948
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15988355
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.15118116
72GATA3_26560356_Chip-Seq_TH2_Human1.12153987
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.09222284
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08760652
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07953766
76E2F7_22180533_ChIP-Seq_HELA_Human1.07278779
77MAF_26560356_Chip-Seq_TH2_Human1.06813866
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06613768
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06599738
80KDM2B_26808549_Chip-Seq_DND41_Human1.04302566
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03955483
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.02940446
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01120553
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00536653
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99027546
86* ESR2_21235772_ChIP-Seq_MCF-7_Human0.98203940
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97619953
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97613808
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97532331
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96816353
91* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93322189
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.92516459
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90527285
94KDM2B_26808549_Chip-Seq_K562_Human0.90345092
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.90341528
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.90139343
97GATA2_19941826_ChIP-Seq_K562_Human0.89352879
98TFEB_21752829_ChIP-Seq_HELA_Human0.88237634
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87693172
100SPI1_20517297_ChIP-Seq_HL60_Human0.86136308
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83141439
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82394539
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82193867
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82193867
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81019520
106GATA1_19941826_ChIP-Seq_K562_Human0.78917822
107* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76923372
108NCOR1_26117541_ChIP-Seq_K562_Human0.76411089
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74771003
110LXR_22292898_ChIP-Seq_THP-1_Human0.74016363
111BCL6_27268052_Chip-Seq_Bcells_Human0.73351837
112BCOR_27268052_Chip-Seq_Bcells_Human0.73073917
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69918322
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68801371
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68664485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.50607862
2MP0003436_decreased_susceptibility_to3.76741267
3MP0003303_peritoneal_inflammation3.44515207
4MP0009785_altered_susceptibility_to3.35778688
5MP0002148_abnormal_hypersensitivity_rea3.17840667
6* MP0002419_abnormal_innate_immunity3.12917000
7* MP0005000_abnormal_immune_tolerance3.00478867
8MP0005025_abnormal_response_to2.88135799
9MP0000685_abnormal_immune_system2.81622268
10MP0001790_abnormal_immune_system2.78947306
11MP0005387_immune_system_phenotype2.78947306
12* MP0002452_abnormal_antigen_presenting2.76827488
13MP0005058_abnormal_lysosome_morphology2.73030022
14* MP0001800_abnormal_humoral_immune2.69318820
15MP0006082_CNS_inflammation2.56055432
16* MP0002723_abnormal_immune_serum2.51883665
17MP0005464_abnormal_platelet_physiology2.42131535
18MP0003724_increased_susceptibility_to2.40883214
19* MP0001819_abnormal_immune_cell2.36802552
20* MP0002420_abnormal_adaptive_immunity2.35438121
21* MP0005671_abnormal_response_to2.24470169
22MP0009278_abnormal_bone_marrow2.24244396
23MP0004510_myositis2.22908375
24MP0004947_skin_inflammation2.12433789
25MP0003172_abnormal_lysosome_physiology2.09751309
26MP0000569_abnormal_digit_pigmentation2.09273201
27MP0002405_respiratory_system_inflammati2.04248763
28MP0005451_abnormal_body_composition1.98158001
29MP0001533_abnormal_skeleton_physiology1.94156542
30MP0001853_heart_inflammation1.88553594
31* MP0001845_abnormal_inflammatory_respons1.88408094
32MP0010155_abnormal_intestine_physiology1.87347864
33MP0002006_tumorigenesis1.83528345
34MP0005397_hematopoietic_system_phenotyp1.78861737
35MP0001545_abnormal_hematopoietic_system1.78861737
36* MP0000716_abnormal_immune_system1.76883500
37* MP0002398_abnormal_bone_marrow1.75085795
38MP0002166_altered_tumor_susceptibility1.66732135
39MP0003300_gastrointestinal_ulcer1.63908677
40MP0003191_abnormal_cellular_cholesterol1.57184933
41MP0003183_abnormal_peptide_metabolism1.56571447
42MP0005310_abnormal_salivary_gland1.54836839
43MP0009764_decreased_sensitivity_to1.53576147
44MP0003448_altered_tumor_morphology1.52987234
45MP0005174_abnormal_tail_pigmentation1.52178826
46MP0008469_abnormal_protein_level1.50305453
47MP0009333_abnormal_splenocyte_physiolog1.49028019
48MP0000343_altered_response_to1.48839634
49* MP0000689_abnormal_spleen_morphology1.47331060
50MP0000858_altered_metastatic_potential1.46774210
51MP0002132_abnormal_respiratory_system1.46326445
52* MP0002429_abnormal_blood_cell1.45949724
53* MP0002722_abnormal_immune_system1.37203203
54MP0002396_abnormal_hematopoietic_system1.33253111
55MP0001873_stomach_inflammation1.30018894
56MP0002998_abnormal_bone_remodeling1.29637758
57MP0004808_abnormal_hematopoietic_stem1.26122652
58MP0008004_abnormal_stomach_pH1.24136402
59MP0000465_gastrointestinal_hemorrhage1.20347922
60MP0003566_abnormal_cell_adhesion1.19265265
61MP0005167_abnormal_blood-brain_barrier1.18549018
62MP0010307_abnormal_tumor_latency1.18208755
63MP0009840_abnormal_foam_cell1.17821118
64MP0005166_decreased_susceptibility_to1.16780757
65MP0003866_abnormal_defecation1.14553794
66MP0005076_abnormal_cell_differentiation1.14437603
67MP0004883_abnormal_blood_vessel1.12649631
68* MP0003075_altered_response_to1.12035655
69MP0000490_abnormal_crypts_of1.11641532
70MP0010352_gastrointestinal_tract_polyps1.07755268
71MP0001851_eye_inflammation1.06222100
72MP0004381_abnormal_hair_follicle1.03543115
73MP0003828_pulmonary_edema1.02983253
74MP0003763_abnormal_thymus_physiology0.96948651
75MP0002254_reproductive_system_inflammat0.96293785
76MP0003453_abnormal_keratinocyte_physiol0.92505075
77MP0000604_amyloidosis0.91475840
78MP0002277_abnormal_respiratory_mucosa0.91046450
79MP0003806_abnormal_nucleotide_metabolis0.91011911
80MP0005390_skeleton_phenotype0.90010887
81MP0008260_abnormal_autophagy0.89887597
82MP0000371_diluted_coat_color0.89587135
83MP0002933_joint_inflammation0.89509898
84MP0003656_abnormal_erythrocyte_physiolo0.88996041
85MP0000015_abnormal_ear_pigmentation0.87778531
86MP0004185_abnormal_adipocyte_glucose0.79490897
87MP0009763_increased_sensitivity_to0.78672718
88MP0005666_abnormal_adipose_tissue0.77710051
89MP0000703_abnormal_thymus_morphology0.77288639
90MP0005164_abnormal_response_to0.77117611
91MP0000249_abnormal_blood_vessel0.74837240
92MP0001958_emphysema0.74667724
93MP0003705_abnormal_hypodermis_morpholog0.72183040
94MP0008874_decreased_physiological_sensi0.70574363
95* MP0002136_abnormal_kidney_physiology0.69948559
96MP0001663_abnormal_digestive_system0.69342695
97MP0003091_abnormal_cell_migration0.69117340
98MP0005023_abnormal_wound_healing0.67539760
99MP0009765_abnormal_xenobiotic_induced0.66400361
100MP0003045_fibrosis0.66246454
101MP0003690_abnormal_glial_cell0.64856601
102MP0000609_abnormal_liver_physiology0.63368978
103MP0002019_abnormal_tumor_incidence0.63287032
104* MP0003795_abnormal_bone_structure0.63112604
105MP0010234_abnormal_vibrissa_follicle0.63021425
106MP0004782_abnormal_surfactant_physiolog0.62030158
107MP0004858_abnormal_nervous_system0.60669931
108MP0009115_abnormal_fat_cell0.60244005
109MP0005319_abnormal_enzyme/_coenzyme0.59608674
110MP0002877_abnormal_melanocyte_morpholog0.59549271
111MP0002139_abnormal_hepatobiliary_system0.56420802
112MP0001216_abnormal_epidermal_layer0.56365490
113MP0001986_abnormal_taste_sensitivity0.53796699
114MP0003186_abnormal_redox_activity0.52854210
115MP0002138_abnormal_hepatobiliary_system0.52506606
116MP0001191_abnormal_skin_condition0.52275039

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.47499135
2Eczematoid dermatitis (HP:0000976)6.98201056
3Recurrent bacterial skin infections (HP:0005406)6.87640776
4Recurrent gram-negative bacterial infections (HP:0005420)5.65004214
5Abnormality of macrophages (HP:0004311)4.96839429
6Mediastinal lymphadenopathy (HP:0100721)4.78927800
7Elevated erythrocyte sedimentation rate (HP:0003565)4.31258293
8Recurrent skin infections (HP:0001581)4.26981502
9Myositis (HP:0100614)4.26056426
10Recurrent fungal infections (HP:0002841)4.20813518
11Gingivitis (HP:0000230)4.11133529
12Vacuolated lymphocytes (HP:0001922)4.03152822
13Increased cerebral lipofuscin (HP:0011813)3.93877915
14Cellulitis (HP:0100658)3.92168256
15Chronic obstructive pulmonary disease (HP:0006510)3.86773423
16Obstructive lung disease (HP:0006536)3.86773423
17Autoimmune thrombocytopenia (HP:0001973)3.80439987
18Recurrent viral infections (HP:0004429)3.70861486
19Orchitis (HP:0100796)3.57686019
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.50846684
21Pustule (HP:0200039)3.47573994
22Periodontitis (HP:0000704)3.33071083
23Retrobulbar optic neuritis (HP:0100654)3.30841016
24Optic neuritis (HP:0100653)3.30841016
25Systemic lupus erythematosus (HP:0002725)3.29917006
26Stomatitis (HP:0010280)3.25588130
27Interstitial pulmonary disease (HP:0006530)3.21983725
28Meningitis (HP:0001287)3.18647618
29Encephalitis (HP:0002383)3.12225074
30* Vasculitis (HP:0002633)3.06954689
31Chronic mucocutaneous candidiasis (HP:0002728)3.05529697
32Recurrent cutaneous fungal infections (HP:0011370)3.05529697
33Purpura (HP:0000979)3.00726765
34Abnormality of glycolipid metabolism (HP:0010969)2.98297895
35Abnormality of liposaccharide metabolism (HP:0010968)2.98297895
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.98297895
37Osteomyelitis (HP:0002754)2.98267715
38Disinhibition (HP:0000734)2.93443612
39Amyloidosis (HP:0011034)2.92395742
40Chronic otitis media (HP:0000389)2.90518304
41Hematochezia (HP:0002573)2.90169221
42Colitis (HP:0002583)2.87447061
43Axonal loss (HP:0003447)2.81675223
44Prostate neoplasm (HP:0100787)2.78132923
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.76067141
46Urticaria (HP:0001025)2.74991872
47Recurrent pneumonia (HP:0006532)2.69838856
48Inflammation of the large intestine (HP:0002037)2.67235026
49Dysostosis multiplex (HP:0000943)2.65688265
50Pulmonary infiltrates (HP:0002113)2.61132739
51Basal ganglia calcification (HP:0002135)2.59666970
52Thick nail (HP:0001805)2.56261437
53Leukocytosis (HP:0001974)2.55097710
54Gastrointestinal inflammation (HP:0004386)2.53975857
55Petechiae (HP:0000967)2.48408713
56Agammaglobulinemia (HP:0004432)2.48362822
57Episodic fever (HP:0001954)2.46706601
58IgM deficiency (HP:0002850)2.44000856
59Recurrent bronchitis (HP:0002837)2.41047026
60Arterial thrombosis (HP:0004420)2.40440846
61Recurrent lower respiratory tract infections (HP:0002783)2.40001738
62Sepsis (HP:0100806)2.37603551
63Thrombocytosis (HP:0001894)2.35194953
64Increased serum ferritin (HP:0003281)2.35156833
65Anorexia (HP:0002039)2.34836810
66Increased IgE level (HP:0003212)2.31668694
67Pulmonary embolism (HP:0002204)2.28912043
68Nasal polyposis (HP:0100582)2.28846683
69Spontaneous hematomas (HP:0007420)2.28196041
70Premature loss of primary teeth (HP:0006323)2.27573008
71Urinary glycosaminoglycan excretion (HP:0003541)2.27313838
72Mucopolysacchariduria (HP:0008155)2.27313838
73Agnosia (HP:0010524)2.24260024
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.23512513
75Osteolytic defects of the hand bones (HP:0009699)2.23512513
76Hemoptysis (HP:0002105)2.22993936
77Skin ulcer (HP:0200042)2.20984813
78Tetraparesis (HP:0002273)2.20190526
79Malnutrition (HP:0004395)2.19448540
80Gingival bleeding (HP:0000225)2.19229855
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.19164024
82Gangrene (HP:0100758)2.18805759
83Prolonged bleeding time (HP:0003010)2.17659000
84T lymphocytopenia (HP:0005403)2.17147705
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16817474
86Abnormality of polysaccharide metabolism (HP:0011012)2.16817474
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16817474
88Hypergammaglobulinemia (HP:0010702)2.16359383
89Abnormality of the nasal mucosa (HP:0000433)2.15261459
90Loss of speech (HP:0002371)2.14671112
91Hypochromic anemia (HP:0001931)2.12796764
92Myocardial infarction (HP:0001658)2.12306102
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11905845
94Abnormal platelet volume (HP:0011876)2.08651855
95Abnormality of T cell number (HP:0011839)2.06691495
96Eosinophilia (HP:0001880)2.06366217
97Abnormality of the pleura (HP:0002103)2.05119776
98Abnormality of iron homeostasis (HP:0011031)2.05056323
99Epistaxis (HP:0000421)2.04917970
100Cheilitis (HP:0100825)2.02421930
101Segmental peripheral demyelination/remyelination (HP:0003481)2.01864961
102Albinism (HP:0001022)1.99163558
103Glomerulopathy (HP:0100820)1.98759439
104Abnormality of the prostate (HP:0008775)1.98514379
105Abnormality of T cells (HP:0002843)1.97771024
106Increased IgM level (HP:0003496)1.96536575
107Peritonitis (HP:0002586)1.96531828
108Thyroiditis (HP:0100646)1.95662074
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95351161
110Keratoconjunctivitis sicca (HP:0001097)1.93106934
111Gastrointestinal infarctions (HP:0005244)1.92584689
112Abnormality of the peritoneum (HP:0002585)1.92203675
113Hypertensive crisis (HP:0100735)1.91634589
114Abnormality of the endocardium (HP:0004306)1.90071437
115Hypochromic microcytic anemia (HP:0004840)1.90050654
116Chest pain (HP:0100749)1.89774192
117Abnormality of T cell physiology (HP:0011840)1.88654348
118Hepatosplenomegaly (HP:0001433)1.85511118
119Thoracic kyphosis (HP:0002942)1.83912159
120Granulocytopenia (HP:0001913)1.80559878
121Bone pain (HP:0002653)1.79105090
122Keratoconjunctivitis (HP:0001096)1.76564568
123Recurrent sinusitis (HP:0011108)1.76396220
124Panhypogammaglobulinemia (HP:0003139)1.76150722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.91688348
2MAP3K143.81565924
3MAP4K13.39783016
4TBK13.39063032
5TYK23.09898946
6IRAK43.06228725
7PRPF4B2.84930777
8KIT2.61953852
9IRAK32.60194604
10ERN12.53299296
11JAK32.41084159
12* RIPK42.33567995
13IKBKE2.29105038
14IKBKB2.21957728
15JAK11.99588553
16TNK21.98268444
17CSF1R1.93420008
18MATK1.79422314
19STK101.72460351
20TAOK21.70922691
21BTK1.69902770
22TGFBR21.69629041
23ZAP701.69619813
24SYK1.68834771
25MAP3K131.66826026
26CSK1.65630906
27TAOK31.59839085
28PIM21.58625273
29TXK1.52942402
30MARK31.51566518
31HCK1.48658500
32MAP3K101.42305448
33SMG11.42121054
34MAP2K31.37515219
35CHUK1.33427595
36PIM11.32329302
37RPS6KA41.30264547
38PBK1.28064072
39EPHB11.26602480
40LRRK21.25692101
41MST41.25677116
42TEC1.25519648
43SIK11.17694571
44* LYN1.16414596
45JAK21.13873895
46TRIB31.13792458
47* LCK1.13412122
48CDC42BPA1.12805331
49MST1R1.12215780
50RIPK11.08606685
51TRPM71.07595858
52TESK21.05498589
53SIK21.04931385
54FES1.04215065
55NME21.00138165
56BMPR20.99952556
57PRKD20.97292031
58IRAK10.96015975
59CLK10.95834265
60MARK20.94284569
61IRAK20.93424062
62NEK90.89472192
63FLT30.87844468
64GRK60.86695855
65PTK60.85166333
66FGR0.84992708
67TESK10.84098004
68STK40.81104591
69FGFR30.80336280
70CAMK1D0.77524342
71BMX0.76349932
72MAP3K30.74569037
73* PDPK10.73406139
74MAP3K110.73165292
75ITK0.71847906
76* PDK10.71292896
77GRK70.70406637
78SIK30.70372157
79TTN0.67613630
80MAPK120.66290610
81EGFR0.64759158
82MAPK70.63668229
83PIK3CG0.62249063
84HIPK20.62239021
85EEF2K0.61860317
86PAK40.60070309
87MAP3K50.59939742
88PKN20.59419874
89MAP3K60.58810639
90CDK60.57350047
91PRKG20.56412188
92FGFR40.55601320
93* ABL10.54023551
94* PRKCD0.53991582
95MAPKAPK20.52390800
96MAP3K10.50981790
97KSR20.50858140
98MAP2K60.50786914
99STK30.49910918
100MOS0.49805215
101SCYL20.48549913
102DDR20.46533534
103CDK120.46295453
104NLK0.44330710
105ABL20.43886096
106ICK0.43772448
107RPS6KA60.43080473
108MAP2K20.42181508
109MAP3K80.41541630
110RET0.41198386
111SGK30.40775435
112MAPKAPK30.40250754
113ARAF0.39097761
114CAMKK10.38216069
115ADRBK20.38121995
116PTK2B0.36869857
117EIF2AK20.36485942
118RPS6KA20.36230392
119MAP3K70.34953766
120MAP3K20.32054269
121PRKCQ0.31466656
122EPHA30.30781310
123CDK40.29682312
124MAPK40.29286361
125RPS6KC10.29009892
126RPS6KL10.29009892
127NEK20.28889579
128ALK0.28392928
129TAOK10.27121529
130* FYN0.27070725

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.44277759
2Osteoclast differentiation_Homo sapiens_hsa043802.63215406
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.59066374
4Staphylococcus aureus infection_Homo sapiens_hsa051502.52000648
5Legionellosis_Homo sapiens_hsa051342.45071728
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.43505814
7B cell receptor signaling pathway_Homo sapiens_hsa046622.29087837
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26416288
9Tuberculosis_Homo sapiens_hsa051522.24763373
10Pertussis_Homo sapiens_hsa051332.21136678
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02898088
12Measles_Homo sapiens_hsa051622.02374381
13Graft-versus-host disease_Homo sapiens_hsa053322.01585470
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94695746
15Malaria_Homo sapiens_hsa051441.88993132
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83487375
17Influenza A_Homo sapiens_hsa051641.81751134
18Hematopoietic cell lineage_Homo sapiens_hsa046401.81705996
19Lysosome_Homo sapiens_hsa041421.81579767
20Salmonella infection_Homo sapiens_hsa051321.79334430
21TNF signaling pathway_Homo sapiens_hsa046681.76792936
22Toxoplasmosis_Homo sapiens_hsa051451.75521336
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.66697660
24Other glycan degradation_Homo sapiens_hsa005111.63929135
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.62209477
26* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59353849
27Rheumatoid arthritis_Homo sapiens_hsa053231.59286011
28Allograft rejection_Homo sapiens_hsa053301.58963093
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58508896
30Asthma_Homo sapiens_hsa053101.53671091
31Primary immunodeficiency_Homo sapiens_hsa053401.53585604
32Antigen processing and presentation_Homo sapiens_hsa046121.53548291
33Apoptosis_Homo sapiens_hsa042101.48980260
34Phagosome_Homo sapiens_hsa041451.48287450
35Shigellosis_Homo sapiens_hsa051311.47288135
36Herpes simplex infection_Homo sapiens_hsa051681.45614298
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45291557
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39122647
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.36580458
40* Chemokine signaling pathway_Homo sapiens_hsa040621.32716314
41African trypanosomiasis_Homo sapiens_hsa051431.26710256
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.24418948
43Acute myeloid leukemia_Homo sapiens_hsa052211.17947995
44Hepatitis B_Homo sapiens_hsa051611.16861764
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14597257
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06143106
47Hepatitis C_Homo sapiens_hsa051601.05392539
48* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03238318
49Chronic myeloid leukemia_Homo sapiens_hsa052201.02640417
50Type I diabetes mellitus_Homo sapiens_hsa049401.02488742
51Amoebiasis_Homo sapiens_hsa051460.95091226
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94675384
53T cell receptor signaling pathway_Homo sapiens_hsa046600.92868730
54Platelet activation_Homo sapiens_hsa046110.91994013
55Viral myocarditis_Homo sapiens_hsa054160.89687385
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88680072
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87394954
58Pancreatic cancer_Homo sapiens_hsa052120.84791140
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82235051
60* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78491709
61Renin-angiotensin system_Homo sapiens_hsa046140.77346783
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77070589
63Epstein-Barr virus infection_Homo sapiens_hsa051690.74905185
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73099778
65Prolactin signaling pathway_Homo sapiens_hsa049170.72348889
66Renal cell carcinoma_Homo sapiens_hsa052110.72278131
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68232195
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64591642
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63712467
70Mineral absorption_Homo sapiens_hsa049780.61386491
71Small cell lung cancer_Homo sapiens_hsa052220.61051988
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.60525775
73VEGF signaling pathway_Homo sapiens_hsa043700.58954203
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58492808
75HIF-1 signaling pathway_Homo sapiens_hsa040660.55403640
76Bladder cancer_Homo sapiens_hsa052190.55348413
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.53666198
78Endometrial cancer_Homo sapiens_hsa052130.50832758
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50040549
80Viral carcinogenesis_Homo sapiens_hsa052030.50024289
81Caffeine metabolism_Homo sapiens_hsa002320.48536678
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46247518
83Choline metabolism in cancer_Homo sapiens_hsa052310.45086133
84* GnRH signaling pathway_Homo sapiens_hsa049120.45025758
85Endocytosis_Homo sapiens_hsa041440.44945195
86Proteoglycans in cancer_Homo sapiens_hsa052050.43354866
87Autoimmune thyroid disease_Homo sapiens_hsa053200.42795784
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42348865
89Sphingolipid metabolism_Homo sapiens_hsa006000.42099058
90Galactose metabolism_Homo sapiens_hsa000520.42071595
91Non-small cell lung cancer_Homo sapiens_hsa052230.40990024
92HTLV-I infection_Homo sapiens_hsa051660.40140747
93Prostate cancer_Homo sapiens_hsa052150.37056019
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36491928
95Insulin signaling pathway_Homo sapiens_hsa049100.36098924
96Collecting duct acid secretion_Homo sapiens_hsa049660.35289512
97Fructose and mannose metabolism_Homo sapiens_hsa000510.34907052
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.32427646
99Dorso-ventral axis formation_Homo sapiens_hsa043200.32363621
100MAPK signaling pathway_Homo sapiens_hsa040100.31654812
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31166423
102Notch signaling pathway_Homo sapiens_hsa043300.30875588
103* Insulin resistance_Homo sapiens_hsa049310.30073007
104mTOR signaling pathway_Homo sapiens_hsa041500.29804058
105Inositol phosphate metabolism_Homo sapiens_hsa005620.29296263
106ErbB signaling pathway_Homo sapiens_hsa040120.28989175
107FoxO signaling pathway_Homo sapiens_hsa040680.28594340
108* Type II diabetes mellitus_Homo sapiens_hsa049300.27612233
109p53 signaling pathway_Homo sapiens_hsa041150.27574442
110Pentose phosphate pathway_Homo sapiens_hsa000300.27295340
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26934735
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26310753
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.25458908
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25168364
115MicroRNAs in cancer_Homo sapiens_hsa052060.24943484
116Prion diseases_Homo sapiens_hsa050200.24562029

Most similar genes based on co-expression Upload to Enrichr

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