PRKCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41099561
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63384145
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51557423
4vocalization behavior (GO:0071625)5.40209648
5locomotory exploration behavior (GO:0035641)5.36051495
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33302467
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.30547669
8synaptic vesicle exocytosis (GO:0016079)5.29074505
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03942661
10* regulation of B cell receptor signaling pathway (GO:0050855)4.94214424
11regulation of glutamate receptor signaling pathway (GO:1900449)4.93266337
12glutamate receptor signaling pathway (GO:0007215)4.90714097
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89739981
14protein localization to synapse (GO:0035418)4.87557874
15synaptic vesicle maturation (GO:0016188)4.85925624
16neuronal action potential propagation (GO:0019227)4.84584038
17regulation of synaptic vesicle exocytosis (GO:2000300)4.79828368
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.68863607
19glutamate secretion (GO:0014047)4.65025411
20neuron cell-cell adhesion (GO:0007158)4.53111403
21regulation of gamma-delta T cell activation (GO:0046643)4.51817935
22exploration behavior (GO:0035640)4.44832385
23synaptic transmission, glutamatergic (GO:0035249)4.44392650
24neuron-neuron synaptic transmission (GO:0007270)4.43519501
25* B cell receptor signaling pathway (GO:0050853)4.38606485
26regulation of gamma-delta T cell differentiation (GO:0045586)4.36277768
27regulation of synaptic vesicle transport (GO:1902803)4.35921344
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35703061
29regulation of neuronal synaptic plasticity (GO:0048168)4.34359038
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.33487517
31positive regulation of B cell differentiation (GO:0045579)4.25933078
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24727606
33positive regulation by symbiont of host defense response (GO:0052509)4.20862965
34modulation by symbiont of host defense response (GO:0052031)4.20862965
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.20862965
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.20862965
37positive regulation by organism of defense response of other organism involved in symbiotic interact4.20862965
38modulation by symbiont of host immune response (GO:0052553)4.20862965
39regulation of synapse structural plasticity (GO:0051823)4.16555368
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.15166196
41long-term memory (GO:0007616)4.13587897
42regulation of dendritic spine morphogenesis (GO:0061001)4.08957908
43long-term synaptic potentiation (GO:0060291)4.05533320
44positive thymic T cell selection (GO:0045059)4.05401797
45* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04251999
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.02792495
47regulation of postsynaptic membrane potential (GO:0060078)4.00607140
48negative thymic T cell selection (GO:0045060)3.99227078
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.99214530
50antigen processing and presentation of endogenous antigen (GO:0019883)3.94477639
51negative T cell selection (GO:0043383)3.94005058
52neurotransmitter secretion (GO:0007269)3.93184470
53negative regulation of erythrocyte differentiation (GO:0045647)3.92819520
54regulation of synaptic plasticity (GO:0048167)3.89305987
55neurotransmitter-gated ion channel clustering (GO:0072578)3.86587491
56dendritic spine morphogenesis (GO:0060997)3.86441787
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85796936
58positive regulation of membrane potential (GO:0045838)3.83457606
59response to interleukin-15 (GO:0070672)3.81766553
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80355173
61regulation of B cell differentiation (GO:0045577)3.80209948
62neutrophil activation involved in immune response (GO:0002283)3.79585002
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78823501
64positive T cell selection (GO:0043368)3.77003813
65macrophage activation involved in immune response (GO:0002281)3.74202146
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73103424
67response to histamine (GO:0034776)3.73044789
68neuron recognition (GO:0008038)3.72872203
69positive regulation of neurotransmitter secretion (GO:0001956)3.65789314
70negative regulation of T cell mediated immunity (GO:0002710)3.64584058
71cellular potassium ion homeostasis (GO:0030007)3.62126320
72positive regulation of synapse maturation (GO:0090129)3.61948252
73layer formation in cerebral cortex (GO:0021819)3.61912819
74behavioral fear response (GO:0001662)3.61266571
75behavioral defense response (GO:0002209)3.61266571
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.60288132
77synaptic vesicle endocytosis (GO:0048488)3.60101827
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.54141582
79behavioral response to cocaine (GO:0048148)3.53926443
80cellular extravasation (GO:0045123)3.53924999
81transmission of nerve impulse (GO:0019226)3.53683442
82long term synaptic depression (GO:0060292)3.51829885
83regulation of dendritic spine development (GO:0060998)3.51777136
84cellular response to interleukin-15 (GO:0071350)3.48017118
85detection of other organism (GO:0098543)3.47677803
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45225847
87positive regulation of neurotransmitter transport (GO:0051590)3.45213770
88T cell selection (GO:0045058)3.45161115
89regulation of glutamate secretion (GO:0014048)3.44792932
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43781559
91fear response (GO:0042596)3.43700756
92presynaptic membrane assembly (GO:0097105)3.40008562
93positive regulation of mast cell activation (GO:0033005)3.39577933
94synaptic transmission, dopaminergic (GO:0001963)3.39170700
95regulation of vesicle fusion (GO:0031338)3.38340799
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38067675
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36964749
98microglial cell activation (GO:0001774)3.36652803
99positive regulation of granulocyte differentiation (GO:0030854)3.36413993
100thymic T cell selection (GO:0045061)3.36182421
101gamma-aminobutyric acid transport (GO:0015812)3.36060180
102T cell migration (GO:0072678)3.35280516
103myeloid cell activation involved in immune response (GO:0002275)3.34370916
104membrane depolarization (GO:0051899)3.32978753
105axonal fasciculation (GO:0007413)3.32860372
106regulation of neurotransmitter secretion (GO:0046928)3.31830681
107detection of bacterium (GO:0016045)3.30827126
108positive regulation of Rap GTPase activity (GO:0032854)3.29354116
109negative regulation of leukocyte mediated immunity (GO:0002704)3.28731848
110learning (GO:0007612)3.26204419
111positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25346149
112neurotransmitter transport (GO:0006836)3.23239985
113positive regulation of dendritic spine morphogenesis (GO:0061003)3.22871147
114presynaptic membrane organization (GO:0097090)3.21560202
115dendritic spine organization (GO:0097061)3.20704836
116neuromuscular process controlling balance (GO:0050885)3.19936564
117immunoglobulin mediated immune response (GO:0016064)3.19698266
118proline transport (GO:0015824)3.19462922
119chemosensory behavior (GO:0007635)3.19047986
120prepulse inhibition (GO:0060134)3.17038267
121activation of protein kinase A activity (GO:0034199)3.17005341
122positive regulation of dendritic spine development (GO:0060999)3.16988009
123regulation of ARF protein signal transduction (GO:0032012)3.16091182
124mast cell activation (GO:0045576)3.15521809
125leukocyte aggregation (GO:0070486)3.14577199
126response to amphetamine (GO:0001975)3.13703698
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13279576
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.10806299
129leukocyte degranulation (GO:0043299)3.10517535
130regulation of female receptivity (GO:0045924)3.10173822
131vesicle transport along microtubule (GO:0047496)3.10005052
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09832487
133positive regulation of synaptic transmission (GO:0050806)3.09729093
134negative regulation of amino acid transport (GO:0051956)3.09354860
135regulation of neurotransmitter transport (GO:0051588)3.09278763
136regulation of voltage-gated calcium channel activity (GO:1901385)3.08365762
137postsynaptic membrane organization (GO:0001941)3.07812952
138regulation of synaptic transmission (GO:0050804)3.06105310
139regulation of mast cell degranulation (GO:0043304)3.05853595
140positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05223072
141striatum development (GO:0021756)3.04476122
142regulation of alpha-beta T cell proliferation (GO:0046640)3.03359660
143membrane depolarization during action potential (GO:0086010)3.03019217
144regulation of neurotransmitter levels (GO:0001505)3.01137096
145cerebellar Purkinje cell differentiation (GO:0021702)3.01117640
146neutrophil activation (GO:0042119)3.00613438
147response to peptidoglycan (GO:0032494)3.00575114
148innervation (GO:0060384)3.00346577
149auditory behavior (GO:0031223)2.99295052
150L-amino acid import (GO:0043092)2.99060622
151regulation of regulated secretory pathway (GO:1903305)2.98348866
152detection of calcium ion (GO:0005513)2.97396370
153negative regulation of cell killing (GO:0031342)2.96830892
154negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96830892
155mating behavior (GO:0007617)2.96615305
156mucosal-associated lymphoid tissue development (GO:0048537)2.96176658
157Peyers patch development (GO:0048541)2.96176658
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96041972
159response to host immune response (GO:0052572)2.96041972
160regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93712946
161detection of external biotic stimulus (GO:0098581)2.92842139
162regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91266762
163interferon-gamma-mediated signaling pathway (GO:0060333)2.91196672
164germinal center formation (GO:0002467)2.89993400
165negative regulation of interleukin-12 production (GO:0032695)2.89578111
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88054776
167activated T cell proliferation (GO:0050798)2.87603223
168regulation of Rap GTPase activity (GO:0032317)2.86336906
169detection of molecule of bacterial origin (GO:0032490)2.85413631
170* antigen receptor-mediated signaling pathway (GO:0050851)2.84064365
171mast cell degranulation (GO:0043303)2.84013131
172mast cell activation involved in immune response (GO:0002279)2.84013131
173regulation of interferon-beta biosynthetic process (GO:0045357)2.81683326
174regulation of beta-amyloid formation (GO:1902003)2.81554686
175regulation of mast cell activation (GO:0033003)2.80484410
176regulation of leukocyte degranulation (GO:0043300)2.79926538
177macrophage activation (GO:0042116)2.78634508
178regulation of mast cell activation involved in immune response (GO:0033006)2.77944019
179response to muramyl dipeptide (GO:0032495)2.77725289
180positive regulation of mast cell degranulation (GO:0043306)2.75407552
181positive regulation of mast cell activation involved in immune response (GO:0033008)2.75407552
182natural killer cell differentiation (GO:0001779)2.74674575
183positive regulation of cellular amide metabolic process (GO:0034250)2.74129113
184granulocyte activation (GO:0036230)2.72825184
185antigen processing and presentation via MHC class Ib (GO:0002475)2.72371615
186negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.71372637
187regulation of amyloid precursor protein catabolic process (GO:1902991)2.70563364
188megakaryocyte development (GO:0035855)2.68966864
189positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67983475
190respiratory burst (GO:0045730)2.67820028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human5.66770397
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74289253
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.22402380
4GBX2_23144817_ChIP-Seq_PC3_Human3.89856551
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.66329536
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44313713
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39101282
8SCL_19346495_ChIP-Seq_HPC-7_Human3.28752847
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24732513
10JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22984118
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13970655
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.06689854
13RUNX_20019798_ChIP-Seq_JUKART_Human2.98794991
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.89505585
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.81220515
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.78929408
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74739193
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74739193
19SPI1_23127762_ChIP-Seq_K562_Human2.72899987
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66261435
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62612299
22MYC_22102868_ChIP-Seq_BL_Human2.62411634
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56676574
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56625265
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55366259
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54189538
27* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54071187
28* MYB_26560356_Chip-Seq_TH2_Human2.50888803
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50606073
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50479615
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47834303
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.47692256
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46735565
34DROSHA_22980978_ChIP-Seq_HELA_Human2.45264662
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44081710
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41327089
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.40675111
38GATA1_22025678_ChIP-Seq_K562_Human2.39794952
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32341841
40MAF_26560356_Chip-Seq_TH1_Human2.30141891
41EGR1_19374776_ChIP-ChIP_THP-1_Human2.28434791
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23226142
43VDR_21846776_ChIP-Seq_THP-1_Human2.22828312
44EED_16625203_ChIP-ChIP_MESCs_Mouse2.22041086
45SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20675097
46REST_18959480_ChIP-ChIP_MESCs_Mouse2.17977709
47RNF2_27304074_Chip-Seq_ESCs_Mouse2.17870885
48VDR_24763502_ChIP-Seq_THP-1_Human2.15791937
49GATA1_19941826_ChIP-Seq_K562_Human2.12774426
50EZH2_27294783_Chip-Seq_ESCs_Mouse2.12369982
51MYB_26560356_Chip-Seq_TH1_Human2.10852524
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09354363
53TAF15_26573619_Chip-Seq_HEK293_Human2.08496161
54* SPI1_23547873_ChIP-Seq_NB4_Human2.02609497
55* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98276881
56UTX_26944678_Chip-Seq_JUKART_Human1.96490921
57AR_21572438_ChIP-Seq_LNCaP_Human1.96245995
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92786780
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92658453
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.91692577
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.90738216
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90232961
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90031548
64TCF7_22412390_ChIP-Seq_EML_Mouse1.89723319
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89491430
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86076070
67* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86039259
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81390044
69KDM2B_26808549_Chip-Seq_DND41_Human1.79957300
70GATA3_27048872_Chip-Seq_THYMUS_Human1.77553293
71* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76781992
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.76468034
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72109919
74MAF_26560356_Chip-Seq_TH2_Human1.71392861
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70718980
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69393312
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68772566
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65783836
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63771477
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59837997
81* P300_19829295_ChIP-Seq_ESCs_Human1.59003058
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58919211
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58088060
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57495246
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57295752
86GATA2_19941826_ChIP-Seq_K562_Human1.57212247
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53110086
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53091018
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.50220490
90VDR_24787735_ChIP-Seq_THP-1_Human1.48557177
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.43772362
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42182482
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38772068
94ZNF274_21170338_ChIP-Seq_K562_Hela1.38661232
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35527124
96AR_25329375_ChIP-Seq_VCAP_Human1.34537698
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34394363
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33865994
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.33857488
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.32028176
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.31181144
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30867724
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29840249
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27830906
105GATA3_26560356_Chip-Seq_TH2_Human1.27549736
106FUS_26573619_Chip-Seq_HEK293_Human1.26355931
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26084079
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26005691
109* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25409406
110* STAT3_23295773_ChIP-Seq_U87_Human1.25084911
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25070330
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23971791
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23545065
114TP53_16413492_ChIP-PET_HCT116_Human1.23240809
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22826230
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22804629
117NCOR1_26117541_ChIP-Seq_K562_Human1.19980041
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.19442807
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18770296
120AR_19668381_ChIP-Seq_PC3_Human1.18224304
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17984786
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.17457557
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16703069
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16398680
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.16010151
126* TCF4_23295773_ChIP-Seq_U87_Human1.15823173
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14930996
128* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14585098
129CIITA_25753668_ChIP-Seq_RAJI_Human1.14310092
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13944966
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12478479
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.12290859
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11460979
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10719712
135WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10408337
136ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09197574
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.08549349
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08329601
139* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07883668
140KDM2B_26808549_Chip-Seq_K562_Human1.06450232
141DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05905186
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05379204
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05308308
144* RUNX2_22187159_ChIP-Seq_PCA_Human1.04965860
145VDR_22108803_ChIP-Seq_LS180_Human1.03899012
146LXR_22292898_ChIP-Seq_THP-1_Human1.03562839
147PU_27001747_Chip-Seq_BMDM_Mouse1.03093184
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02797352
149IGF1R_20145208_ChIP-Seq_DFB_Human1.02527265
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02135893
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01970653
152* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01331540
153RING1B_27294783_Chip-Seq_NPCs_Mouse1.00942901
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00811988
155TP53_18474530_ChIP-ChIP_U2OS_Human1.00102561
156* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99507409
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99402179
158BCAT_22108803_ChIP-Seq_LS180_Human0.99396188
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98975019
160JUN_21703547_ChIP-Seq_K562_Human0.98865218
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98740110
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.98536227
163ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98222633
164AHR_22903824_ChIP-Seq_MCF-7_Human0.97877931
165RNF2_27304074_Chip-Seq_NSC_Mouse0.97742652
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97661829
167EGR1_19032775_ChIP-ChIP_M12_Human0.97603671
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.95765098
169PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94870574
170FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94384933
171* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93913735
172SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93718544
173PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93047691
174TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92526826
175RXR_22108803_ChIP-Seq_LS180_Human0.92270875
176CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92062108
177CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91388810
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90332063
179* SMRT_27268052_Chip-Seq_Bcells_Human0.90070007
180* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89958954
181EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89594294
182ER_23166858_ChIP-Seq_MCF-7_Human0.88755970
183ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88588160
184PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88086618
185GATA2_21666600_ChIP-Seq_HMVEC_Human0.84642331
186CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83438089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.75618611
2MP0003880_abnormal_central_pattern5.73367888
3MP0003635_abnormal_synaptic_transmissio4.38586544
4MP0009745_abnormal_behavioral_response3.76365973
5MP0004270_analgesia3.75248076
6* MP0002063_abnormal_learning/memory/cond3.56836808
7MP0001835_abnormal_antigen_presentation3.47608529
8MP0002064_seizures3.34694214
9MP0002822_catalepsy3.33878744
10MP0001968_abnormal_touch/_nociception3.15823446
11MP0002572_abnormal_emotion/affect_behav3.03975254
12MP0009046_muscle_twitch3.02645343
13MP0003724_increased_susceptibility_to2.97886256
14MP0005671_abnormal_response_to2.95231782
15MP0003436_decreased_susceptibility_to2.88697028
16MP0002272_abnormal_nervous_system2.74632282
17* MP0001800_abnormal_humoral_immune2.73797028
18MP0001501_abnormal_sleep_pattern2.67327875
19MP0001486_abnormal_startle_reflex2.63019379
20MP0002736_abnormal_nociception_after2.59081960
21MP0005000_abnormal_immune_tolerance2.58245811
22MP0003763_abnormal_thymus_physiology2.46035092
23MP0005464_abnormal_platelet_physiology2.40869948
24MP0005387_immune_system_phenotype2.38392152
25MP0001790_abnormal_immune_system2.38392152
26MP0002734_abnormal_mechanical_nocicepti2.37878349
27MP0001440_abnormal_grooming_behavior2.33783826
28MP0000685_abnormal_immune_system2.31270792
29* MP0002723_abnormal_immune_serum2.29041035
30MP0005423_abnormal_somatic_nervous2.28716734
31* MP0002420_abnormal_adaptive_immunity2.28555648
32MP0002419_abnormal_innate_immunity2.24899820
33* MP0001819_abnormal_immune_cell2.24413963
34* MP0002452_abnormal_antigen_presenting2.16681888
35MP0005025_abnormal_response_to2.13692733
36MP0002735_abnormal_chemical_nociception2.12178721
37* MP0002398_abnormal_bone_marrow2.10716651
38MP0003329_amyloid_beta_deposits2.02179107
39MP0002067_abnormal_sensory_capabilities2.01732216
40MP0002733_abnormal_thermal_nociception1.95646240
41MP0001970_abnormal_pain_threshold1.92481748
42MP0008569_lethality_at_weaning1.89423517
43MP0002909_abnormal_adrenal_gland1.84038595
44* MP0000716_abnormal_immune_system1.83772815
45MP0005386_behavior/neurological_phenoty1.80277784
46MP0004924_abnormal_behavior1.80277784
47MP0001529_abnormal_vocalization1.78337058
48MP0009785_altered_susceptibility_to1.77670001
49MP0003879_abnormal_hair_cell1.71724457
50MP0002396_abnormal_hematopoietic_system1.71158777
51MP0002557_abnormal_social/conspecific_i1.70547182
52MP0002148_abnormal_hypersensitivity_rea1.70198180
53MP0009780_abnormal_chondrocyte_physiolo1.67229614
54MP0002184_abnormal_innervation1.66755824
55MP0004811_abnormal_neuron_physiology1.64338625
56MP0000778_abnormal_nervous_system1.61700248
57MP0000689_abnormal_spleen_morphology1.60543953
58MP0000703_abnormal_thymus_morphology1.59359406
59MP0002722_abnormal_immune_system1.58078765
60MP0001984_abnormal_olfaction1.52703695
61MP0006082_CNS_inflammation1.52525836
62MP0005646_abnormal_pituitary_gland1.47769275
63* MP0002429_abnormal_blood_cell1.47504237
64MP0003866_abnormal_defecation1.47261013
65MP0003300_gastrointestinal_ulcer1.44535760
66MP0003787_abnormal_imprinting1.44496180
67MP0006276_abnormal_autonomic_nervous1.42247556
68MP0002405_respiratory_system_inflammati1.41750331
69MP0002066_abnormal_motor_capabilities/c1.40267973
70MP0004947_skin_inflammation1.40009188
71MP0008260_abnormal_autophagy1.38461921
72MP0001905_abnormal_dopamine_level1.37480890
73MP0001188_hyperpigmentation1.37353813
74MP0003633_abnormal_nervous_system1.35764863
75MP0000955_abnormal_spinal_cord1.34121481
76MP0001545_abnormal_hematopoietic_system1.33591070
77MP0005397_hematopoietic_system_phenotyp1.33591070
78MP0004510_myositis1.33502545
79MP0009278_abnormal_bone_marrow1.30882098
80MP0001845_abnormal_inflammatory_respons1.27425277
81MP0010155_abnormal_intestine_physiology1.27170661
82MP0005409_darkened_coat_color1.26983105
83MP0002882_abnormal_neuron_morphology1.26377299
84MP0004858_abnormal_nervous_system1.26168837
85MP0009333_abnormal_splenocyte_physiolog1.26153665
86MP0003183_abnormal_peptide_metabolism1.23807195
87MP0002837_dystrophic_cardiac_calcinosis1.23651881
88MP0003656_abnormal_erythrocyte_physiolo1.20372192
89MP0001502_abnormal_circadian_rhythm1.19690294
90MP0008874_decreased_physiological_sensi1.15715294
91MP0003631_nervous_system_phenotype1.13784983
92MP0004381_abnormal_hair_follicle1.12326185
93MP0004142_abnormal_muscle_tone1.12157463
94MP0005451_abnormal_body_composition1.12071693
95MP0001986_abnormal_taste_sensitivity1.10980942
96MP0001533_abnormal_skeleton_physiology1.10980421
97MP0003045_fibrosis1.10247781
98MP0002166_altered_tumor_susceptibility1.08913212
99MP0000604_amyloidosis1.08038333
100MP0004885_abnormal_endolymph1.07296704
101MP0008872_abnormal_physiological_respon1.04788443
102MP0005645_abnormal_hypothalamus_physiol1.04747755
103MP0004130_abnormal_muscle_cell1.04506476
104MP0010386_abnormal_urinary_bladder1.03961850
105MP0001851_eye_inflammation1.01769175
106MP0003075_altered_response_to1.01708105
107MP0000465_gastrointestinal_hemorrhage1.01390836
108MP0005535_abnormal_body_temperature1.00499552
109MP0002152_abnormal_brain_morphology1.00256784
110MP0004742_abnormal_vestibular_system0.96094225
111MP0002132_abnormal_respiratory_system0.95319178
112MP0004145_abnormal_muscle_electrophysio0.95085638
113MP0000013_abnormal_adipose_tissue0.94802982
114MP0002069_abnormal_eating/drinking_beha0.92860988
115MP0004147_increased_porphyrin_level0.91998319
116MP0000015_abnormal_ear_pigmentation0.89472985
117MP0002229_neurodegeneration0.88966164
118MP0008057_abnormal_DNA_replication0.87238912
119MP0004808_abnormal_hematopoietic_stem0.85472485
120MP0000920_abnormal_myelination0.84602779
121MP0008877_abnormal_DNA_methylation0.84051159
122MP0004484_altered_response_of0.83797440
123MP0009764_decreased_sensitivity_to0.82119308
124MP0008961_abnormal_basal_metabolism0.81881544
125MP0002876_abnormal_thyroid_physiology0.80868261
126MP0008469_abnormal_protein_level0.80574196
127MP0005551_abnormal_eye_electrophysiolog0.79756033
128MP0000569_abnormal_digit_pigmentation0.79043025
129MP0003828_pulmonary_edema0.78093351
130MP0010234_abnormal_vibrissa_follicle0.77736954
131MP0001963_abnormal_hearing_physiology0.77004051
132MP0004085_abnormal_heartbeat0.76889293
133MP0003690_abnormal_glial_cell0.76048775
134MP0001873_stomach_inflammation0.75904577
135MP0005075_abnormal_melanosome_morpholog0.75612389
136MP0002006_tumorigenesis0.74125041
137MP0003632_abnormal_nervous_system0.73282595
138MP0001177_atelectasis0.71335134
139MP0005394_taste/olfaction_phenotype0.70168606
140MP0005499_abnormal_olfactory_system0.70168606
141MP0003634_abnormal_glial_cell0.68550309
142MP0000751_myopathy0.67657120
143MP0005167_abnormal_blood-brain_barrier0.67306555
144MP0001664_abnormal_digestion0.63045420
145MP0000631_abnormal_neuroendocrine_gland0.62113300
146MP0001485_abnormal_pinna_reflex0.60948463
147MP0002090_abnormal_vision0.60504610
148MP0004215_abnormal_myocardial_fiber0.59619367
149MP0005310_abnormal_salivary_gland0.59406333
150MP0001765_abnormal_ion_homeostasis0.59252970
151MP0002752_abnormal_somatic_nervous0.56474295
152MP0003122_maternal_imprinting0.56470893
153MP0005166_decreased_susceptibility_to0.54780453
154MP0001943_abnormal_respiration0.49262474
155MP0003303_peritoneal_inflammation0.48017532
156MP0003956_abnormal_body_size0.47690124
157MP0006292_abnormal_olfactory_placode0.47031234
158MP0003172_abnormal_lysosome_physiology0.44885428
159MP0010769_abnormal_survival0.44089667
160MP0005187_abnormal_penis_morphology0.42166065
161MP0010770_preweaning_lethality0.42099515

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.01290154
2Myokymia (HP:0002411)6.77991199
3Focal seizures (HP:0007359)6.44299643
4Visual hallucinations (HP:0002367)5.69521250
5Epileptic encephalopathy (HP:0200134)5.29749620
6Atonic seizures (HP:0010819)5.20655281
7Febrile seizures (HP:0002373)4.92963197
8Absence seizures (HP:0002121)4.88785849
9Eczematoid dermatitis (HP:0000976)4.63109357
10Recurrent bacterial skin infections (HP:0005406)4.54564269
11Dialeptic seizures (HP:0011146)4.48363294
12Hyperventilation (HP:0002883)4.31431583
13Recurrent abscess formation (HP:0002722)4.28283080
14Generalized tonic-clonic seizures (HP:0002069)4.20609464
15Progressive cerebellar ataxia (HP:0002073)4.10917774
16Broad-based gait (HP:0002136)4.06953011
17Poor eye contact (HP:0000817)3.81436708
18Action tremor (HP:0002345)3.77757844
19Meningitis (HP:0001287)3.77397219
20Amblyopia (HP:0000646)3.71407003
21Gaze-evoked nystagmus (HP:0000640)3.65461614
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.63646648
23Recurrent fungal infections (HP:0002841)3.63618330
24Agammaglobulinemia (HP:0004432)3.61323880
25Supranuclear gaze palsy (HP:0000605)3.60899007
26Myositis (HP:0100614)3.56034752
27Chronic obstructive pulmonary disease (HP:0006510)3.53172322
28Obstructive lung disease (HP:0006536)3.53172322
29Prolonged bleeding time (HP:0003010)3.50233615
30Retrobulbar optic neuritis (HP:0100654)3.44300026
31Optic neuritis (HP:0100653)3.44300026
32Dysmetria (HP:0001310)3.41175487
33Truncal ataxia (HP:0002078)3.41033374
34Cerebral inclusion bodies (HP:0100314)3.40903827
35Abnormality of macrophages (HP:0004311)3.39738128
36Panhypogammaglobulinemia (HP:0003139)3.39458664
37Abnormal social behavior (HP:0012433)3.37655375
38Impaired social interactions (HP:0000735)3.37655375
39Dysdiadochokinesis (HP:0002075)3.34758176
40Anxiety (HP:0000739)3.28668608
41T lymphocytopenia (HP:0005403)3.28326972
42Impaired vibration sensation in the lower limbs (HP:0002166)3.26041880
43Depression (HP:0000716)3.22349897
44Stomatitis (HP:0010280)3.21288055
45Orchitis (HP:0100796)3.19719650
46Recurrent viral infections (HP:0004429)3.19417458
47Gastrointestinal infarctions (HP:0005244)3.18335795
48Elevated erythrocyte sedimentation rate (HP:0003565)3.17873396
49Cellulitis (HP:0100658)3.15878835
50Impaired smooth pursuit (HP:0007772)3.15642628
51Encephalitis (HP:0002383)3.14933889
52Chronic mucocutaneous candidiasis (HP:0002728)3.13462005
53Recurrent cutaneous fungal infections (HP:0011370)3.13462005
54Recurrent skin infections (HP:0001581)3.13458331
55Vasculitis (HP:0002633)3.11823075
56Abnormality of T cell number (HP:0011839)3.11818895
57Mediastinal lymphadenopathy (HP:0100721)3.11398324
58Neurofibrillary tangles (HP:0002185)3.05721981
59Diplopia (HP:0000651)3.04049438
60Abnormality of binocular vision (HP:0011514)3.04049438
61Excessive salivation (HP:0003781)2.99661400
62Drooling (HP:0002307)2.99661400
63Spontaneous hematomas (HP:0007420)2.98264345
64Recurrent gram-negative bacterial infections (HP:0005420)2.93935671
65Urinary bladder sphincter dysfunction (HP:0002839)2.92588531
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90203485
67Papilledema (HP:0001085)2.85423592
68Colitis (HP:0002583)2.84937012
69Scanning speech (HP:0002168)2.84133961
70Stereotypic behavior (HP:0000733)2.83106133
71Slow saccadic eye movements (HP:0000514)2.81981262
72Absent speech (HP:0001344)2.80965568
73Epistaxis (HP:0000421)2.80662583
74Abnormality of T cells (HP:0002843)2.79812900
75Postural instability (HP:0002172)2.78374626
76Hemiparesis (HP:0001269)2.76250912
77Inflammation of the large intestine (HP:0002037)2.76234363
78Epileptiform EEG discharges (HP:0011182)2.71626354
79Gastrointestinal inflammation (HP:0004386)2.67180288
80Abnormality of ocular smooth pursuit (HP:0000617)2.62673886
81Chest pain (HP:0100749)2.60875929
82Progressive inability to walk (HP:0002505)2.60735756
83Abnormal eating behavior (HP:0100738)2.57357406
84Keratoconjunctivitis sicca (HP:0001097)2.56923432
85Mutism (HP:0002300)2.56541615
86Dysmetric saccades (HP:0000641)2.54851065
87Ankle clonus (HP:0011448)2.54420421
88Bradykinesia (HP:0002067)2.54107844
89Gastrointestinal stroma tumor (HP:0100723)2.52633115
90Granulocytopenia (HP:0001913)2.50248980
91Urinary urgency (HP:0000012)2.50037768
92Status epilepticus (HP:0002133)2.49189559
93Gingival bleeding (HP:0000225)2.49143804
94EEG with generalized epileptiform discharges (HP:0011198)2.48243590
95Osteomyelitis (HP:0002754)2.42586679
96IgM deficiency (HP:0002850)2.41264981
97Inability to walk (HP:0002540)2.40078488
98Lymphopenia (HP:0001888)2.39061646
99Increased IgE level (HP:0003212)2.38994202
100Genetic anticipation (HP:0003743)2.38445237
101Resting tremor (HP:0002322)2.37693787
102Keratoconjunctivitis (HP:0001096)2.37005939
103Pulmonary infiltrates (HP:0002113)2.35737683
104Urticaria (HP:0001025)2.35357261
105Recurrent bronchitis (HP:0002837)2.34740213
106Arterial thrombosis (HP:0004420)2.33774628
107Leukocytosis (HP:0001974)2.32754134
108Chronic otitis media (HP:0000389)2.31510553
109Spastic gait (HP:0002064)2.31184086
110Abnormality of T cell physiology (HP:0011840)2.30619721
111Autoimmune hemolytic anemia (HP:0001890)2.29677656
112Intention tremor (HP:0002080)2.28889790
113Protruding tongue (HP:0010808)2.26717207
114Annular pancreas (HP:0001734)2.26210956
115Pulmonary embolism (HP:0002204)2.26083553
116Termporal pattern (HP:0011008)2.25686166
117Insidious onset (HP:0003587)2.25686166
118Papilloma (HP:0012740)2.25641655
119Verrucae (HP:0200043)2.25641655
120Hypsarrhythmia (HP:0002521)2.25456239
121Generalized myoclonic seizures (HP:0002123)2.25317726
122Impaired vibratory sensation (HP:0002495)2.25248215
123Torticollis (HP:0000473)2.24705739
124Abnormality of the lower motor neuron (HP:0002366)2.23739722
125Petechiae (HP:0000967)2.22522523
126Hemoptysis (HP:0002105)2.22519715
127Gingivitis (HP:0000230)2.21714399
128Abnormality of cells of the lymphoid lineage (HP:0012140)2.21427928
129Delusions (HP:0000746)2.20860245
130Psychosis (HP:0000709)2.19297838
131Peripheral hypomyelination (HP:0007182)2.16611154
132Focal dystonia (HP:0004373)2.16606217
133Abnormality of salivation (HP:0100755)2.14258186
134Inappropriate behavior (HP:0000719)2.14196091
135Hemiplegia (HP:0002301)2.10949804
136Memory impairment (HP:0002354)2.09339813
137Recurrent sinusitis (HP:0011108)2.09206218
138Fetal akinesia sequence (HP:0001989)2.08132283
139Neuronal loss in central nervous system (HP:0002529)2.08105588
140Blue irides (HP:0000635)2.07812707
141Gait ataxia (HP:0002066)2.05031323
142Eosinophilia (HP:0001880)2.04347880
143Vertigo (HP:0002321)2.04127179
144Episodic fever (HP:0001954)2.03985389
145Sepsis (HP:0100806)2.03239562
146Hydroureter (HP:0000072)2.03183572
147Ankyloglossia (HP:0010296)2.02580946
148Viral hepatitis (HP:0006562)2.02346961
149Pustule (HP:0200039)2.01708089
150Abnormality of the fingertips (HP:0001211)2.01426206
151Ventricular fibrillation (HP:0001663)2.00568966
152Lower limb asymmetry (HP:0100559)2.00561513
153Thickened helices (HP:0000391)1.98197764
154Incomplete penetrance (HP:0003829)1.97002052
155Widely spaced teeth (HP:0000687)1.96768537
156IgG deficiency (HP:0004315)1.95414600
157Abnormality of the corticospinal tract (HP:0002492)1.94490607
158Megalencephaly (HP:0001355)1.94137252
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.94133317
160Hypochromic anemia (HP:0001931)1.92573556
161Rapidly progressive (HP:0003678)1.92172607
162Increased IgM level (HP:0003496)1.91921156
163Amyotrophic lateral sclerosis (HP:0007354)1.91543813
164Generalized hypopigmentation of hair (HP:0011358)1.91332948
165Lower limb amyotrophy (HP:0007210)1.91331476
166Polycythemia (HP:0001901)1.89820721
167Abnormality of B cell number (HP:0010975)1.88654323
168Craniofacial dystonia (HP:0012179)1.87937797
169Pointed chin (HP:0000307)1.86659343
170Lower limb muscle weakness (HP:0007340)1.86429585
171Deep palmar crease (HP:0006191)1.85279648
172Apathy (HP:0000741)1.85274071
173Global brain atrophy (HP:0002283)1.85135770
174Deeply set eye (HP:0000490)1.80986614
175Fair hair (HP:0002286)1.79908447
176Abnormality of saccadic eye movements (HP:0000570)1.74485670
177Clumsiness (HP:0002312)1.73740725
178Rigidity (HP:0002063)1.73738526
179Autism (HP:0000717)1.73022574
180Abnormality of oral frenula (HP:0000190)1.65674992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.22700990
2NTRK34.76569760
3* RIPK43.68080401
4MAP3K93.67717898
5MAP4K13.48316654
6MAP3K42.97080165
7BLK2.70359365
8DAPK22.68161077
9MAP2K72.54674696
10MINK12.48818442
11MAP3K122.41218469
12KSR22.34214781
13MAP3K132.14507206
14BTK2.03039689
15SIK22.00026605
16DAPK11.96856770
17PNCK1.96572531
18MAP2K41.93495535
19ARAF1.91843985
20PAK61.88968182
21CASK1.88269353
22KSR11.85128560
23TYK21.83551000
24NTRK11.82606306
25TXK1.81845100
26PLK21.81391330
27FES1.80383150
28CAMKK11.76508710
29MARK11.75848665
30TAOK31.73428585
31IRAK41.69805353
32CSK1.68300412
33NTRK21.61535051
34TEC1.56779218
35CDK51.56190382
36JAK21.55462001
37JAK11.51448563
38GRK51.51244337
39JAK31.49358177
40ZAP701.48402373
41MAP2K31.47241738
42HCK1.45678633
43CAMKK21.40273297
44CDK191.38338313
45PRKD31.37405506
46ITK1.35779738
47PTK2B1.33998777
48RAF11.33005877
49TNIK1.28963632
50MAP3K141.27868112
51LYN1.24585594
52PRKCG1.20185513
53PRPF4B1.19890142
54MAP3K21.15349707
55IKBKE1.12861645
56FGR1.10848700
57CAMK2A1.10768231
58STK381.07515669
59LCK1.05932354
60CAMK2B1.03776200
61MAP3K111.02622341
62NME11.02150640
63GRK60.95636600
64MAPK130.94839737
65TYRO30.93552041
66CSF1R0.89484314
67KIT0.87932751
68UHMK10.85037231
69STK110.83645925
70CAMK10.83549017
71SGK10.80896260
72CDK180.78994917
73PDK10.77871720
74CDK150.76620288
75CDK140.75391605
76FGFR30.75265894
77MARK30.75197884
78MATK0.75132463
79TNK20.72654490
80SGK2230.72281511
81SGK4940.72281511
82PDPK10.71918406
83DYRK1A0.71624370
84ERN10.70982858
85IRAK20.70981009
86PRKCH0.70691867
87RET0.69917663
88MAP3K10.68006949
89SGK20.67675780
90PIK3CG0.67650939
91CDK11A0.66816019
92OXSR10.66492945
93PIM10.64687294
94TBK10.61636520
95TAOK10.58384392
96MAPK70.56688627
97SGK30.54798742
98FYN0.54785442
99MARK20.52778472
100PRKCQ0.52618878
101CAMK2D0.52606693
102SIK30.52434562
103CDK120.52402897
104CCNB10.51536873
105PRKCE0.51348209
106PINK10.51244702
107YES10.50742381
108IKBKB0.50020910
109CAMK1G0.49656491
110HIPK20.48872965
111MAP2K10.48442251
112DMPK0.48071858
113MAP3K70.47079434
114PRKCZ0.46139122
115CSNK1G20.45815549
116DAPK30.45451077
117GRK70.44530568
118RPS6KA30.44197317
119MAP3K60.44177829
120MAPK100.43482930
121PAK30.43234416
122BRAF0.42978422
123MAPK120.42290285
124CAMK2G0.42121897
125ROCK20.40615648
126MOS0.39748057
127TAOK20.37655824
128WNK10.37387258
129MAPK40.36312560
130LRRK20.34972651
131PRKD20.34414811
132IRAK10.34040282
133ALK0.32346973
134CAMK40.32164609
135NEK60.30547759
136PRKACA0.30416107
137* PRKCB0.29546568
138* SYK0.29465000
139* PRKCA0.27803634
140CSNK1A10.25055230
141CDC42BPA0.24828287

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92932499
2* Long-term potentiation_Homo sapiens_hsa047203.06241456
3Synaptic vesicle cycle_Homo sapiens_hsa047212.92646427
4Olfactory transduction_Homo sapiens_hsa047402.77888083
5* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77795047
6* Circadian entrainment_Homo sapiens_hsa047132.70106258
7* Glutamatergic synapse_Homo sapiens_hsa047242.69329165
8* Amphetamine addiction_Homo sapiens_hsa050312.65541699
9* Morphine addiction_Homo sapiens_hsa050322.59481041
10* GABAergic synapse_Homo sapiens_hsa047272.47896921
11Primary immunodeficiency_Homo sapiens_hsa053402.42113996
12Allograft rejection_Homo sapiens_hsa053302.34602795
13Graft-versus-host disease_Homo sapiens_hsa053322.30096031
14* Salivary secretion_Homo sapiens_hsa049702.28649734
15* Leishmaniasis_Homo sapiens_hsa051402.27701705
16* Dopaminergic synapse_Homo sapiens_hsa047282.23379673
17Autoimmune thyroid disease_Homo sapiens_hsa053202.20653562
18Renin secretion_Homo sapiens_hsa049242.08506434
19Taste transduction_Homo sapiens_hsa047421.99064171
20* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86628733
21* Gastric acid secretion_Homo sapiens_hsa049711.84761780
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.81820508
23* Cholinergic synapse_Homo sapiens_hsa047251.81612728
24* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78880978
25* Long-term depression_Homo sapiens_hsa047301.78071321
26* Oxytocin signaling pathway_Homo sapiens_hsa049211.77715660
27* Calcium signaling pathway_Homo sapiens_hsa040201.76688069
28* Insulin secretion_Homo sapiens_hsa049111.76251387
29* Serotonergic synapse_Homo sapiens_hsa047261.73996634
30Asthma_Homo sapiens_hsa053101.73618865
31Collecting duct acid secretion_Homo sapiens_hsa049661.70902220
32Staphylococcus aureus infection_Homo sapiens_hsa051501.66949628
33Cocaine addiction_Homo sapiens_hsa050301.65451137
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61338176
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53721107
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51324716
37* GnRH signaling pathway_Homo sapiens_hsa049121.44800605
38Acute myeloid leukemia_Homo sapiens_hsa052211.42760669
39Antigen processing and presentation_Homo sapiens_hsa046121.37476946
40cAMP signaling pathway_Homo sapiens_hsa040241.36870312
41* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31209636
42Hematopoietic cell lineage_Homo sapiens_hsa046401.29423375
43* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29182930
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27178725
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27069981
46* Gap junction_Homo sapiens_hsa045401.23792751
47Measles_Homo sapiens_hsa051621.23491838
48Estrogen signaling pathway_Homo sapiens_hsa049151.19720827
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19026451
50Toxoplasmosis_Homo sapiens_hsa051451.16480395
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14616329
52* NF-kappa B signaling pathway_Homo sapiens_hsa040641.14423478
53Viral myocarditis_Homo sapiens_hsa054161.13314110
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13173882
55Type II diabetes mellitus_Homo sapiens_hsa049301.11360779
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09505885
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09430103
58* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07359787
59* Influenza A_Homo sapiens_hsa051641.05676598
60* Glioma_Homo sapiens_hsa052141.02751628
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00084290
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99196281
63Vibrio cholerae infection_Homo sapiens_hsa051100.98892968
64Axon guidance_Homo sapiens_hsa043600.97293305
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.97145437
66Phototransduction_Homo sapiens_hsa047440.96390850
67Cardiac muscle contraction_Homo sapiens_hsa042600.95175065
68* Vascular smooth muscle contraction_Homo sapiens_hsa042700.92572572
69* Melanogenesis_Homo sapiens_hsa049160.91110039
70* Pancreatic secretion_Homo sapiens_hsa049720.90867893
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90023083
72Herpes simplex infection_Homo sapiens_hsa051680.89564180
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.89075937
74Oocyte meiosis_Homo sapiens_hsa041140.89029879
75Prolactin signaling pathway_Homo sapiens_hsa049170.84944373
76Chronic myeloid leukemia_Homo sapiens_hsa052200.84556033
77Dorso-ventral axis formation_Homo sapiens_hsa043200.84481654
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84240621
79* ErbB signaling pathway_Homo sapiens_hsa040120.83842069
80* Hepatitis B_Homo sapiens_hsa051610.80424793
81Pancreatic cancer_Homo sapiens_hsa052120.79905447
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77910624
83Alzheimers disease_Homo sapiens_hsa050100.77112376
84Phagosome_Homo sapiens_hsa041450.76670054
85* VEGF signaling pathway_Homo sapiens_hsa043700.74718966
86TNF signaling pathway_Homo sapiens_hsa046680.74483567
87* Choline metabolism in cancer_Homo sapiens_hsa052310.73539306
88* MAPK signaling pathway_Homo sapiens_hsa040100.72732283
89Malaria_Homo sapiens_hsa051440.71125402
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.67996288
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65175919
92Inositol phosphate metabolism_Homo sapiens_hsa005620.65148360
93Type I diabetes mellitus_Homo sapiens_hsa049400.64752256
94* Thyroid hormone synthesis_Homo sapiens_hsa049180.62988138
95* Leukocyte transendothelial migration_Homo sapiens_hsa046700.62856388
96Apoptosis_Homo sapiens_hsa042100.61838137
97Glucagon signaling pathway_Homo sapiens_hsa049220.61734120
98Shigellosis_Homo sapiens_hsa051310.58951404
99Dilated cardiomyopathy_Homo sapiens_hsa054140.57739626
100Hepatitis C_Homo sapiens_hsa051600.57700287
101* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57651091
102Epstein-Barr virus infection_Homo sapiens_hsa051690.57522509
103Endometrial cancer_Homo sapiens_hsa052130.57376992
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56439630
105* Rap1 signaling pathway_Homo sapiens_hsa040150.55351105
106* Sphingolipid signaling pathway_Homo sapiens_hsa040710.54439002
107Legionellosis_Homo sapiens_hsa051340.54351150
108* Ras signaling pathway_Homo sapiens_hsa040140.52987199
109* Chemokine signaling pathway_Homo sapiens_hsa040620.52189936
110Alcoholism_Homo sapiens_hsa050340.50993503
111* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48406914
112T cell receptor signaling pathway_Homo sapiens_hsa046600.46789648
113* B cell receptor signaling pathway_Homo sapiens_hsa046620.46189060
114Oxidative phosphorylation_Homo sapiens_hsa001900.45930197
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45806972
116* African trypanosomiasis_Homo sapiens_hsa051430.44855360
117Prion diseases_Homo sapiens_hsa050200.42853175
118Rheumatoid arthritis_Homo sapiens_hsa053230.42194726
119Platelet activation_Homo sapiens_hsa046110.42081707
120Endocytosis_Homo sapiens_hsa041440.40411692
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40012093
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39839308
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38409566
124* Non-small cell lung cancer_Homo sapiens_hsa052230.37358749
125Renal cell carcinoma_Homo sapiens_hsa052110.37050110
126* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36597092
127Tuberculosis_Homo sapiens_hsa051520.36188986
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34771056
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34547665
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33535233
131* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32326516
132Salmonella infection_Homo sapiens_hsa051320.30293853
133Circadian rhythm_Homo sapiens_hsa047100.29760452
134Osteoclast differentiation_Homo sapiens_hsa043800.29401580
135* Wnt signaling pathway_Homo sapiens_hsa043100.28628347
136* mTOR signaling pathway_Homo sapiens_hsa041500.28261294
137Parkinsons disease_Homo sapiens_hsa050120.27663524
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26325434

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