PRKACA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transport (GO:1901380)4.77815027
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.73273997
3synaptic vesicle maturation (GO:0016188)4.62031264
4plasma membrane repair (GO:0001778)4.48008781
5* cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.18934866
6regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.10018543
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.98194735
8cardiac myofibril assembly (GO:0055003)3.89700613
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88812541
10locomotory exploration behavior (GO:0035641)3.87244720
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86821035
12tricarboxylic acid cycle (GO:0006099)3.86515461
13* cell communication by electrical coupling (GO:0010644)3.82743297
14regulation of membrane repolarization (GO:0060306)3.75404188
15actin-mediated cell contraction (GO:0070252)3.73012511
16sarcomere organization (GO:0045214)3.72177767
17* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.70322053
18skeletal muscle contraction (GO:0003009)3.67509539
19cardiac muscle contraction (GO:0060048)3.66305892
20regulation of synapse structural plasticity (GO:0051823)3.56711386
21sodium ion export (GO:0071436)3.54621543
22* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.53739571
23* cell communication involved in cardiac conduction (GO:0086065)3.51495141
24glutamate secretion (GO:0014047)3.51050926
25negative regulation of erythrocyte differentiation (GO:0045647)3.50373012
26synaptic vesicle exocytosis (GO:0016079)3.49810490
27* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.48668629
28carnitine shuttle (GO:0006853)3.47174906
29* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.46282174
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45594492
31* activation of protein kinase A activity (GO:0034199)3.39475424
32creatine metabolic process (GO:0006600)3.37788358
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.34559964
34membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.32520763
35positive regulation of myotube differentiation (GO:0010831)3.30515952
36regulation of early endosome to late endosome transport (GO:2000641)3.29229527
37regulation of synaptic vesicle exocytosis (GO:2000300)3.27119910
38proline transport (GO:0015824)3.26846127
39myofibril assembly (GO:0030239)3.25822160
40positive regulation of potassium ion transmembrane transport (GO:1901381)3.25292449
41layer formation in cerebral cortex (GO:0021819)3.24033970
42actin filament-based movement (GO:0030048)3.23038266
43cell-substrate adherens junction assembly (GO:0007045)3.20833521
44focal adhesion assembly (GO:0048041)3.20833521
45vocalization behavior (GO:0071625)3.16074844
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13513151
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13416916
48ventricular cardiac muscle cell action potential (GO:0086005)3.10906908
49protein localization to endosome (GO:0036010)3.09855300
50stress fiber assembly (GO:0043149)3.09366190
51adherens junction assembly (GO:0034333)3.09357171
52neurotransmitter secretion (GO:0007269)3.06900122
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.05473885
54fatty acid transmembrane transport (GO:1902001)3.05347397
55positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.02748152
56barbed-end actin filament capping (GO:0051016)3.02220644
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01106976
58regulation of cell communication by electrical coupling (GO:0010649)2.99498614
59regulation of synaptic vesicle transport (GO:1902803)2.99157884
60membrane repolarization during action potential (GO:0086011)2.94968678
61negative regulation of potassium ion transport (GO:0043267)2.94678307
62potassium ion import (GO:0010107)2.94211762
63* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.94131499
64* regulation of calcium ion transmembrane transport (GO:1903169)2.94131499
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.93625146
66membrane repolarization (GO:0086009)2.93554000
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92078307
68exploration behavior (GO:0035640)2.92063006
69positive regulation of receptor recycling (GO:0001921)2.91707747
70sarcoplasmic reticulum calcium ion transport (GO:0070296)2.90904582
71neuromuscular process controlling posture (GO:0050884)2.90018504
72cellular potassium ion homeostasis (GO:0030007)2.89991430
73negative regulation of cell killing (GO:0031342)2.88074739
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88074739
75regulation of glutamate receptor signaling pathway (GO:1900449)2.87322507
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87073205
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87026395
78muscle filament sliding (GO:0030049)2.86214822
79actin-myosin filament sliding (GO:0033275)2.86214822
80regulation of acyl-CoA biosynthetic process (GO:0050812)2.85649075
81striated muscle contraction (GO:0006941)2.83399257
82cell migration in hindbrain (GO:0021535)2.82990601
83NADH metabolic process (GO:0006734)2.82978899
84membrane depolarization during action potential (GO:0086010)2.79703268
85cardiac conduction (GO:0061337)2.78811711
86regulation of potassium ion transmembrane transport (GO:1901379)2.78141016
87regulation of heart rate by cardiac conduction (GO:0086091)2.77784568
88regulation of potassium ion transmembrane transporter activity (GO:1901016)2.77374348
89neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77223446
90regulation of cofactor metabolic process (GO:0051193)2.74882632
91regulation of coenzyme metabolic process (GO:0051196)2.74882632
92negative regulation of cell size (GO:0045792)2.74204433
93cerebellar Purkinje cell layer development (GO:0021680)2.73524044
94detection of calcium ion (GO:0005513)2.71633851
95positive regulation of potassium ion transport (GO:0043268)2.70679969
96regulation of actin filament-based movement (GO:1903115)2.68816950
97regulation of the force of heart contraction (GO:0002026)2.67861476
98regulation of ARF protein signal transduction (GO:0032012)2.67741405
99glycine transport (GO:0015816)2.67215509
100neuronal action potential propagation (GO:0019227)2.66508204
101cardiac muscle hypertrophy (GO:0003300)2.64113255
102cardiac muscle cell action potential involved in contraction (GO:0086002)2.63793625
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.62875807
104positive regulation of protein dephosphorylation (GO:0035307)2.61769103
105positive regulation of sodium ion transport (GO:0010765)2.60995431
106regulation of relaxation of muscle (GO:1901077)2.60294576
107regulation of neuronal synaptic plasticity (GO:0048168)2.60105621
108actomyosin structure organization (GO:0031032)2.60015278
109regulation of fatty acid oxidation (GO:0046320)2.58553233
110basement membrane organization (GO:0071711)2.57590195
111cardiac muscle cell action potential (GO:0086001)2.57545782
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54399148
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54399148
114positive regulation by organism of defense response of other organism involved in symbiotic interact2.54399148
115modulation by symbiont of host immune response (GO:0052553)2.54399148
116positive regulation by symbiont of host defense response (GO:0052509)2.54399148
117modulation by symbiont of host defense response (GO:0052031)2.54399148
118carnitine transmembrane transport (GO:1902603)2.54232645
119striated muscle hypertrophy (GO:0014897)2.54109625
120negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53261043
121protein targeting to plasma membrane (GO:0072661)2.52930628
122neuromuscular process controlling balance (GO:0050885)2.52774419
123cell-substrate junction assembly (GO:0007044)2.52538822
124relaxation of cardiac muscle (GO:0055119)2.51463772
125establishment of nucleus localization (GO:0040023)2.49760475
126cardiac muscle cell development (GO:0055013)2.47737979
127potassium ion homeostasis (GO:0055075)2.47533397
128alanine transport (GO:0032328)2.46805045
129protein localization to synapse (GO:0035418)2.46424534
130cellular sodium ion homeostasis (GO:0006883)2.45164822
131cortical actin cytoskeleton organization (GO:0030866)2.44589252
132mannose metabolic process (GO:0006013)2.43291240
133negative regulation of fatty acid transport (GO:2000192)2.42996350
134muscle contraction (GO:0006936)2.42359163
135response to laminar fluid shear stress (GO:0034616)2.42165746
136muscle hypertrophy (GO:0014896)2.40269237
137detection of molecule of bacterial origin (GO:0032490)2.38431127
138response to inactivity (GO:0014854)2.38027220
139cardiac muscle adaptation (GO:0014887)2.37880840
140cardiac muscle hypertrophy in response to stress (GO:0014898)2.37880840
141muscle hypertrophy in response to stress (GO:0003299)2.37880840
142skeletal muscle fiber development (GO:0048741)2.37302219
143regulation of T-helper 2 cell differentiation (GO:0045628)2.37186395
144cerebellar granule cell differentiation (GO:0021707)2.36256837
145regulation of skeletal muscle contraction (GO:0014819)2.35135397
146negative regulation of necroptotic process (GO:0060546)2.32745011
147maternal placenta development (GO:0001893)2.27855404
148striated muscle adaptation (GO:0014888)2.26960862
149negative regulation of skeletal muscle tissue development (GO:0048642)2.25673580
150negative regulation of homotypic cell-cell adhesion (GO:0034111)2.25637512
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23284296
152positive regulation of blood vessel endothelial cell migration (GO:0043536)2.20640759
153regulation of NFAT protein import into nucleus (GO:0051532)2.20301677
154response to peptidoglycan (GO:0032494)2.20262296
155muscle system process (GO:0003012)2.19603870
156macrophage activation involved in immune response (GO:0002281)2.19531445
157cell-cell junction maintenance (GO:0045217)2.19436894
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.18939694
159regulation of macrophage cytokine production (GO:0010935)2.18445918
160regulation of extracellular matrix disassembly (GO:0010715)2.16141041
161response to muscle activity (GO:0014850)2.15652495
162regulation of ARF GTPase activity (GO:0032312)2.15499874
163regulation of necroptotic process (GO:0060544)2.14618355
164* cellular response to monoamine stimulus (GO:0071868)2.14506034
165* cellular response to catecholamine stimulus (GO:0071870)2.14506034
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.14106940
167adenosine receptor signaling pathway (GO:0001973)2.13364861
168signal complex assembly (GO:0007172)2.11718985
169cortical cytoskeleton organization (GO:0030865)2.11348197
170germinal center formation (GO:0002467)2.10724571
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.10168825
172apoptotic process involved in morphogenesis (GO:0060561)2.08881047
1733-UTR-mediated mRNA stabilization (GO:0070935)2.08873074
174detection of other organism (GO:0098543)2.08323132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44268240
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.01964331
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.57155295
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46041078
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32303209
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32303209
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29886622
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.28077682
9DROSHA_22980978_ChIP-Seq_HELA_Human2.27363607
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.24957631
11* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15255768
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15135333
13TCF7_22412390_ChIP-Seq_EML_Mouse2.13950546
14* VDR_21846776_ChIP-Seq_THP-1_Human2.13169330
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12173323
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09206149
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05221461
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04252269
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02539088
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01798450
21* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95919007
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93081310
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.90649871
24REST_21632747_ChIP-Seq_MESCs_Mouse1.86245122
25* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84932473
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.83531592
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79808350
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.78727623
29MYC_22102868_ChIP-Seq_BL_Human1.78014118
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.76935567
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.76694167
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75915653
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74875609
34KDM2B_26808549_Chip-Seq_K562_Human1.73997417
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73813156
36ZNF263_19887448_ChIP-Seq_K562_Human1.70892987
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67414312
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.65361312
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63226092
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63029506
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.61193016
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.61132562
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58280102
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56255730
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54103261
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.52798860
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.52697470
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52629936
49GBX2_23144817_ChIP-Seq_PC3_Human1.51336684
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51139496
51* VDR_24763502_ChIP-Seq_THP-1_Human1.50236153
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48867427
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48118516
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45446802
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42067591
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.37914506
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.37914506
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37330631
59* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36505266
60LXR_22292898_ChIP-Seq_THP-1_Human1.36298865
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.34340646
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34226664
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32497528
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31915368
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.31455711
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.30625498
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30258109
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27113699
69P68_20966046_ChIP-Seq_HELA_Human1.26400564
70ZNF274_21170338_ChIP-Seq_K562_Hela1.26356970
71* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26266954
72SPI1_23127762_ChIP-Seq_K562_Human1.25520226
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25379420
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.24840731
75* TET1_21451524_ChIP-Seq_MESCs_Mouse1.24603291
76MAF_26560356_Chip-Seq_TH1_Human1.24018801
77* KDM2B_26808549_Chip-Seq_DND41_Human1.23922409
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23427130
79* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23422481
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.22686270
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21957753
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21942778
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21764738
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21499149
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21233365
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20921941
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20473923
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.20294015
89CTCF_27219007_Chip-Seq_Bcells_Human1.19616351
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19319744
91* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19301982
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18067239
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17772050
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16930106
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16805226
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16047648
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15474871
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.14165251
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13320151
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12720658
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12699847
102SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12585954
103AR_19668381_ChIP-Seq_PC3_Human1.11977899
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11906823
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.11726586
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.09246856
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09164744
108AR_21572438_ChIP-Seq_LNCaP_Human1.07815776
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07529387
110* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07275460
111* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06160048
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04964007
113UTX_26944678_Chip-Seq_JUKART_Human1.04656322
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04558981
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.03567987
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03054745
117* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02397015
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00769282
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00611041
120* CREB1_26743006_Chip-Seq_LNCaP_Human1.00596643
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00283664
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00126736
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.99613741
124MAF_26560356_Chip-Seq_TH2_Human0.99510625
125SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99066586
126SMC4_20622854_ChIP-Seq_HELA_Human0.98378041
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98247655
128KLF4_19829295_ChIP-Seq_ESCs_Human0.98006938
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.97805812
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97290875
131CLOCK_20551151_ChIP-Seq_293T_Human0.95572474
132AHR_22903824_ChIP-Seq_MCF-7_Human0.95494812
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94777330
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.94002812
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93469413
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93017843
137* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92634603
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92606567
139GATA1_19941826_ChIP-Seq_K562_Human0.92437011
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92335845
141SMAD4_21799915_ChIP-Seq_A2780_Human0.91877396
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.90349866
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89945044
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87976487
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.85750866
146OCT4_19829295_ChIP-Seq_ESCs_Human0.85749796
147* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85698087
148TP53_20018659_ChIP-ChIP_R1E_Mouse0.85449426
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84841703
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84780531
151* RACK7_27058665_Chip-Seq_MCF-7_Human0.84572734
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84513568
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83703762
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82753412
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.82433324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.41523192
2MP0000751_myopathy3.94164040
3MP0004859_abnormal_synaptic_plasticity3.91969328
4MP0004084_abnormal_cardiac_muscle3.18842840
5MP0005451_abnormal_body_composition3.07416996
6MP0003646_muscle_fatigue2.90747384
7MP0008438_abnormal_cutaneous_collagen2.85576497
8MP0004215_abnormal_myocardial_fiber2.82646974
9MP0004270_analgesia2.55208435
10MP0004130_abnormal_muscle_cell2.55034738
11MP0004036_abnormal_muscle_relaxation2.48865202
12MP0003635_abnormal_synaptic_transmissio2.45346397
13MP0000749_muscle_degeneration2.26273180
14MP0005330_cardiomyopathy2.22812794
15MP0002909_abnormal_adrenal_gland2.19355655
16MP0004087_abnormal_muscle_fiber2.11605505
17MP0005058_abnormal_lysosome_morphology2.10375911
18MP0004145_abnormal_muscle_electrophysio2.02136370
19MP0004858_abnormal_nervous_system1.98741465
20MP0003137_abnormal_impulse_conducting1.97479993
21MP0009780_abnormal_chondrocyte_physiolo1.97027496
22MP0003880_abnormal_central_pattern1.93192300
23MP0002972_abnormal_cardiac_muscle1.89920110
24MP0003828_pulmonary_edema1.89885599
25MP0003191_abnormal_cellular_cholesterol1.87260914
26MP0003279_aneurysm1.86508137
27MP0004233_abnormal_muscle_weight1.85578504
28MP0000747_muscle_weakness1.79691584
29MP0003566_abnormal_cell_adhesion1.79317970
30MP0002063_abnormal_learning/memory/cond1.78484042
31MP0003436_decreased_susceptibility_to1.77265708
32MP0005620_abnormal_muscle_contractility1.77056230
33MP0003303_peritoneal_inflammation1.75469682
34MP0009745_abnormal_behavioral_response1.73553751
35MP0005409_darkened_coat_color1.73189982
36MP0001958_emphysema1.71604824
37MP0002269_muscular_atrophy1.71360415
38MP0002064_seizures1.70990982
39MP0003122_maternal_imprinting1.69688015
40MP0008775_abnormal_heart_ventricle1.69266685
41MP0009046_muscle_twitch1.67982948
42MP0005623_abnormal_meninges_morphology1.66953628
43MP0004085_abnormal_heartbeat1.66225746
44MP0000733_abnormal_muscle_development1.65929643
45MP0003300_gastrointestinal_ulcer1.65757484
46MP0009840_abnormal_foam_cell1.63699145
47MP0002822_catalepsy1.58528096
48MP0002106_abnormal_muscle_physiology1.56851853
49MP0008260_abnormal_autophagy1.56637218
50MP0006138_congestive_heart_failure1.53575922
51MP0000759_abnormal_skeletal_muscle1.52998955
52MP0001544_abnormal_cardiovascular_syste1.52127577
53MP0005385_cardiovascular_system_phenoty1.52127577
54MP0004484_altered_response_of1.51053345
55MP0002734_abnormal_mechanical_nocicepti1.50257877
56MP0010630_abnormal_cardiac_muscle1.48187576
57MP0003329_amyloid_beta_deposits1.47921160
58MP0003091_abnormal_cell_migration1.47161244
59MP0000013_abnormal_adipose_tissue1.47123146
60MP0000750_abnormal_muscle_regeneration1.46669087
61MP0003172_abnormal_lysosome_physiology1.45828692
62MP0008961_abnormal_basal_metabolism1.42758284
63MP0002272_abnormal_nervous_system1.42150906
64MP0001968_abnormal_touch/_nociception1.39071819
65MP0003705_abnormal_hypodermis_morpholog1.36933052
66MP0002572_abnormal_emotion/affect_behav1.36486647
67MP0002733_abnormal_thermal_nociception1.33213003
68MP0005369_muscle_phenotype1.32969930
69MP0005423_abnormal_somatic_nervous1.31839077
70MP0008569_lethality_at_weaning1.30489107
71MP0003075_altered_response_to1.29774506
72MP0003283_abnormal_digestive_organ1.28196840
73MP0005666_abnormal_adipose_tissue1.26725783
74MP0001849_ear_inflammation1.23734486
75MP0002735_abnormal_chemical_nociception1.22502747
76MP0002877_abnormal_melanocyte_morpholog1.22292498
77MP0005670_abnormal_white_adipose1.21712975
78MP0004811_abnormal_neuron_physiology1.21545759
79MP0005076_abnormal_cell_differentiation1.21160643
80MP0004924_abnormal_behavior1.19801206
81MP0005386_behavior/neurological_phenoty1.19801206
82MP0003690_abnormal_glial_cell1.17320625
83MP0001970_abnormal_pain_threshold1.16669915
84MP0006276_abnormal_autonomic_nervous1.16241734
85MP0000767_abnormal_smooth_muscle1.12582040
86MP0005375_adipose_tissue_phenotype1.10797578
87MP0000003_abnormal_adipose_tissue1.09938217
88MP0001486_abnormal_startle_reflex1.09047862
89MP0009278_abnormal_bone_marrow1.08770234
90MP0005535_abnormal_body_temperature1.07582178
91MP0001440_abnormal_grooming_behavior1.06972647
92MP0002067_abnormal_sensory_capabilities1.06716458
93MP0001533_abnormal_skeleton_physiology1.06325530
94MP0003724_increased_susceptibility_to1.06277764
95MP0000955_abnormal_spinal_cord1.04901058
96MP0002184_abnormal_innervation1.04623772
97MP0002998_abnormal_bone_remodeling1.01859622
98MP0001501_abnormal_sleep_pattern1.01501206
99MP0000604_amyloidosis1.00727415
100MP0004185_abnormal_adipocyte_glucose1.00527792
101MP0005503_abnormal_tendon_morphology1.00297727
102MP0004510_myositis0.99234965
103MP0005275_abnormal_skin_tensile0.98820292
104MP0003633_abnormal_nervous_system0.98669343
105MP0000343_altered_response_to0.96886673
106MP0002234_abnormal_pharynx_morphology0.96467521
107MP0003221_abnormal_cardiomyocyte_apopto0.96290727
108MP0000858_altered_metastatic_potential0.95777959
109MP0002249_abnormal_larynx_morphology0.93367565
110MP0002332_abnormal_exercise_endurance0.92274943
111MP0002066_abnormal_motor_capabilities/c0.91991174
112MP0005166_decreased_susceptibility_to0.91773593
113MP0003045_fibrosis0.90713191
114MP0000920_abnormal_myelination0.90027938
115MP0002419_abnormal_innate_immunity0.89172222
116MP0002736_abnormal_nociception_after0.88833052
117MP0005165_increased_susceptibility_to0.86131511
118MP0003123_paternal_imprinting0.86093547
119MP0004272_abnormal_basement_membrane0.81789414
120MP0010368_abnormal_lymphatic_system0.81306647
121* MP0002882_abnormal_neuron_morphology0.80553121
122MP0002557_abnormal_social/conspecific_i0.80052250
123MP0006036_abnormal_mitochondrial_physio0.79480380
124MP0005167_abnormal_blood-brain_barrier0.79308208
125MP0005257_abnormal_intraocular_pressure0.78838306
126MP0002108_abnormal_muscle_morphology0.78486730
127MP0002971_abnormal_brown_adipose0.78450491
128MP0005187_abnormal_penis_morphology0.76915524
129* MP0002078_abnormal_glucose_homeostasis0.75695149
130MP0000778_abnormal_nervous_system0.75609275
131MP0005023_abnormal_wound_healing0.75541851
132MP0003453_abnormal_keratinocyte_physiol0.73875614
133MP0001299_abnormal_eye_distance/0.73723920
134MP0004885_abnormal_endolymph0.73608773
135MP0003879_abnormal_hair_cell0.73077790
136MP0003631_nervous_system_phenotype0.71438308
137MP0004947_skin_inflammation0.69918885
138MP0005390_skeleton_phenotype0.69362039
139MP0001851_eye_inflammation0.68879881
140MP0005645_abnormal_hypothalamus_physiol0.68288899
141MP0001348_abnormal_lacrimal_gland0.68166056
142MP0004043_abnormal_pH_regulation0.67774123
143MP0000678_abnormal_parathyroid_gland0.67547162
144MP0008874_decreased_physiological_sensi0.67053774
145MP0002089_abnormal_postnatal_growth/wei0.66704687
146MP0005464_abnormal_platelet_physiology0.66357515
147* MP0002896_abnormal_bone_mineralization0.65953170
148MP0003634_abnormal_glial_cell0.65750537
149MP0005025_abnormal_response_to0.65026410
150MP0005448_abnormal_energy_balance0.65005319
151MP0002127_abnormal_cardiovascular_syste0.64888031

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.17207425
2Muscle fiber inclusion bodies (HP:0100299)4.56159201
3Nemaline bodies (HP:0003798)4.53060922
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.51024597
5Exercise-induced myalgia (HP:0003738)4.21041364
6Myokymia (HP:0002411)3.95233936
7Bundle branch block (HP:0011710)3.76962080
8Exercise-induced muscle cramps (HP:0003710)3.70925989
9Distal lower limb muscle weakness (HP:0009053)3.69925093
10Ventricular fibrillation (HP:0001663)3.67043102
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.66587963
12Round ear (HP:0100830)3.63882699
13Calf muscle hypertrophy (HP:0008981)3.53291172
14Myoglobinuria (HP:0002913)3.48956856
15Hyporeflexia of lower limbs (HP:0002600)3.48726630
16Pheochromocytoma (HP:0002666)3.44769067
17Ulnar deviation of the wrist (HP:0003049)3.42900057
18Atrial fibrillation (HP:0005110)3.39781557
19Myopathic facies (HP:0002058)3.36118436
20Distal arthrogryposis (HP:0005684)3.33815174
21Difficulty running (HP:0009046)3.28478411
22Primary atrial arrhythmia (HP:0001692)3.27870292
23Prolonged QT interval (HP:0001657)3.24656030
24Abnormality of the calf musculature (HP:0001430)3.23737698
25Muscle hypertrophy of the lower extremities (HP:0008968)3.19642527
26Syncope (HP:0001279)3.17127202
27Muscle fiber splitting (HP:0003555)3.14817740
28Protrusio acetabuli (HP:0003179)3.11159717
29Supraventricular tachycardia (HP:0004755)3.10687661
30Myotonia (HP:0002486)3.08729790
31Ventricular tachycardia (HP:0004756)3.07895527
32Supraventricular arrhythmia (HP:0005115)3.07578855
33Visual hallucinations (HP:0002367)2.95780597
34Subaortic stenosis (HP:0001682)2.93179774
35Abnormality of the left ventricular outflow tract (HP:0011103)2.93179774
36Obstructive sleep apnea (HP:0002870)2.92236709
37Ventricular arrhythmia (HP:0004308)2.90413797
38Focal motor seizures (HP:0011153)2.87272501
39Asymmetric septal hypertrophy (HP:0001670)2.87097093
40Distal lower limb amyotrophy (HP:0008944)2.86766421
41Neuroendocrine neoplasm (HP:0100634)2.86601262
42EMG: myopathic abnormalities (HP:0003458)2.81507712
43Heart block (HP:0012722)2.73972289
44Palpitations (HP:0001962)2.71381611
45Action tremor (HP:0002345)2.67901395
46Abnormal EKG (HP:0003115)2.67053736
47Atrioventricular block (HP:0001678)2.66738548
48Increased variability in muscle fiber diameter (HP:0003557)2.65044616
49Dysmetric saccades (HP:0000641)2.62114785
50Focal seizures (HP:0007359)2.58372542
51Abnormal atrioventricular conduction (HP:0005150)2.56371070
52Lipoatrophy (HP:0100578)2.55925902
53Premature rupture of membranes (HP:0001788)2.53591149
54Spinal rigidity (HP:0003306)2.52369946
55Increased connective tissue (HP:0009025)2.50948995
56Type 1 muscle fiber predominance (HP:0003803)2.47857122
57Abnormality of the lower motor neuron (HP:0002366)2.47717661
58Neck muscle weakness (HP:0000467)2.47493239
59Calcaneovalgus deformity (HP:0001848)2.44485531
60Difficulty climbing stairs (HP:0003551)2.43522359
61Right ventricular cardiomyopathy (HP:0011663)2.41975130
62Slender build (HP:0001533)2.41569605
63Depression (HP:0000716)2.37419922
64Ketoacidosis (HP:0001993)2.35453734
65Muscle stiffness (HP:0003552)2.33612593
66Neoplasm of the peripheral nervous system (HP:0100007)2.32674603
67Abnormality of skeletal muscle fiber size (HP:0012084)2.30930230
68Supranuclear gaze palsy (HP:0000605)2.27146936
69Bulbar palsy (HP:0001283)2.26611584
70Hamartoma of the eye (HP:0010568)2.24737477
71Ankle clonus (HP:0011448)2.23476081
72Eczematoid dermatitis (HP:0000976)2.14274048
73Rapidly progressive (HP:0003678)2.13195201
74Deformed tarsal bones (HP:0008119)2.12270332
75Mildly elevated creatine phosphokinase (HP:0008180)2.12016219
76Anxiety (HP:0000739)2.11621367
77Achilles tendon contracture (HP:0001771)2.11304214
78EMG: neuropathic changes (HP:0003445)2.10439399
79Dilated cardiomyopathy (HP:0001644)2.07707978
80Atonic seizures (HP:0010819)2.07317532
81Postural instability (HP:0002172)2.06995628
82Broad metatarsal (HP:0001783)2.02948188
83Vertebral compression fractures (HP:0002953)2.02791120
84Insidious onset (HP:0003587)2.02607741
85Termporal pattern (HP:0011008)2.02607741
86Generalized tonic-clonic seizures (HP:0002069)2.01465553
87Rhabdomyolysis (HP:0003201)2.00343553
88Lower limb amyotrophy (HP:0007210)1.98516212
89Impaired social interactions (HP:0000735)1.98278051
90Abnormal social behavior (HP:0012433)1.98278051
91Impaired vibration sensation in the lower limbs (HP:0002166)1.98271657
92Peritonitis (HP:0002586)1.97256561
93Enlarged penis (HP:0000040)1.95774024
94Lymphangioma (HP:0100764)1.94664915
95Abnormality of the Achilles tendon (HP:0005109)1.93893394
96Frequent falls (HP:0002359)1.93602295
97Absence seizures (HP:0002121)1.92235179
98Progressive cerebellar ataxia (HP:0002073)1.92084265
99Aneurysm (HP:0002617)1.91851933
100Urinary urgency (HP:0000012)1.90022037
101Abnormality of the calcaneus (HP:0008364)1.89332360
102Conjunctival hamartoma (HP:0100780)1.88770762
103Vascular tortuosity (HP:0004948)1.88118957
104Urinary bladder sphincter dysfunction (HP:0002839)1.88114352
105Dysdiadochokinesis (HP:0002075)1.86244431
106Poor eye contact (HP:0000817)1.85849352
107Insomnia (HP:0100785)1.85825140
108Hypoventilation (HP:0002791)1.85524742
109Cerebral aneurysm (HP:0004944)1.85057040
110Oligomenorrhea (HP:0000876)1.84594855
111Scapular winging (HP:0003691)1.83806765
112Easy fatigability (HP:0003388)1.83273266
113Axonal loss (HP:0003447)1.82427875
114Generalized amyotrophy (HP:0003700)1.82391655
115Athetosis (HP:0002305)1.81502620
116Arterial tortuosity (HP:0005116)1.81366609
117Aortic aneurysm (HP:0004942)1.81292737
118Left ventricular hypertrophy (HP:0001712)1.80474532
119Neoplasm of the heart (HP:0100544)1.78105962
120Neurofibrillary tangles (HP:0002185)1.77993318
121Impaired pain sensation (HP:0007328)1.77612027
122Abnormality of pain sensation (HP:0010832)1.77612027
123Shallow orbits (HP:0000586)1.76600311
124Hemiplegia (HP:0002301)1.76343609
125Foot dorsiflexor weakness (HP:0009027)1.76286513
126Abnormality of the foot musculature (HP:0001436)1.75912207
127Macroorchidism (HP:0000053)1.75665841
128Upper limb amyotrophy (HP:0009129)1.75365668
129Distal upper limb amyotrophy (HP:0007149)1.75365668
130Neoplasm of the adrenal gland (HP:0100631)1.75149131
131Dilatation of the ascending aorta (HP:0005111)1.74619815
132Cerebral inclusion bodies (HP:0100314)1.74520807
133Torticollis (HP:0000473)1.74249509
134* Hypercortisolism (HP:0001578)1.72979016
135Limb-girdle muscle atrophy (HP:0003797)1.72728594
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72542321
137Agitation (HP:0000713)1.72348159
138Hyperacusis (HP:0010780)1.71982239
139Genetic anticipation (HP:0003743)1.71124658
140Thin ribs (HP:0000883)1.70690686
141Amyloidosis (HP:0011034)1.70522185
142Malignant hyperthermia (HP:0002047)1.68333912
143Mitral regurgitation (HP:0001653)1.68168009
144Fetal akinesia sequence (HP:0001989)1.68166971
145Deep venous thrombosis (HP:0002625)1.66771319
146Abnormality of macrophages (HP:0004311)1.65809730
147Gowers sign (HP:0003391)1.64929210
148Areflexia of lower limbs (HP:0002522)1.64703475
149Polycythemia (HP:0001901)1.64418291
150Generalized muscle weakness (HP:0003324)1.62820430
151Recurrent gram-negative bacterial infections (HP:0005420)1.61942510
152Ragged-red muscle fibers (HP:0003200)1.61082386
153Disproportionate tall stature (HP:0001519)1.60773972
154Thin bony cortex (HP:0002753)1.58242219
155Dysostosis multiplex (HP:0000943)1.55584960
156Spontaneous hematomas (HP:0007420)1.54628082
157Ankle contracture (HP:0006466)1.52206844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.44324812
2LMTK22.97150078
3NTRK32.91524836
4PHKG12.74693281
5PHKG22.74693281
6ERN12.72622835
7PKN22.68002884
8MAP3K92.59048937
9PRKD32.29681712
10TTN2.13222205
11MAP2K32.13164007
12MAP3K42.11544209
13MINK12.06974003
14PAK62.04406657
15KSR22.00332931
16RIPK42.00284964
17PDK31.99420181
18PDK41.99420181
19NEK11.94958373
20LATS21.82941029
21MARK11.80481856
22EPHB11.74923936
23MAP2K41.71174095
24SMG11.71003358
25CAMKK11.67903684
26RIPK11.62129418
27STK381.55624077
28NTRK11.52250900
29MAP3K131.51379906
30DMPK1.48427410
31EEF2K1.40772805
32EPHA41.37136237
33PINK11.35704914
34PAK31.33733432
35DAPK21.33555354
36FGFR41.32403825
37MOS1.29034222
38PDGFRA1.28828480
39RET1.26373843
40TAOK21.25688477
41MAP3K111.25280460
42TESK11.24369314
43TAOK11.22255687
44MAP3K31.19312499
45CDK121.16801855
46PRKCH1.13411795
47NTRK21.11825078
48OBSCN1.10631703
49ICK1.08154110
50IRAK31.07502241
51WNK11.06874736
52TYRO31.06671041
53PRKD21.05822211
54UHMK11.03157423
55ZAP701.02997623
56CAMK1G1.01578931
57CDK50.96881091
58KSR10.96362820
59TYK20.96164470
60MAP3K20.95724631
61MYLK0.95684258
62CDC42BPA0.92013153
63SIK10.90583895
64BCKDK0.90103673
65ALK0.89979745
66BLK0.89553177
67MAP3K70.88378407
68MAP3K120.87453615
69* PDPK10.87416060
70GRK50.87404591
71MAP2K70.86989317
72SCYL20.86209519
73MAPK70.85038534
74MAP3K60.82371601
75SGK30.81615548
76CSK0.80426513
77TNK20.80271428
78PDK20.79853210
79PRKD10.78241799
80PIK3CG0.77593546
81WNK40.77244598
82ROCK10.75922134
83MAP3K10.75302825
84ILK0.73496166
85CAMK1D0.72524053
86MTOR0.71714745
87ARAF0.70471733
88CAMK2A0.69966125
89MAP2K10.67305660
90STK110.67078174
91CAMKK20.67057532
92DYRK1B0.66642459
93DAPK30.66182028
94CAMK2D0.66124057
95FER0.65386155
96CAMK10.65101467
97PRKCG0.64459875
98RPS6KL10.64121804
99RPS6KC10.64121804
100SIK30.63936411
101SGK2230.63743732
102SGK4940.63743732
103IRAK40.63437327
104LRRK20.62538574
105PRKAA10.62093537
106TGFBR20.61949924
107PTK2B0.61638528
108LIMK10.61489845
109TBK10.60720447
110TESK20.59129449
111DDR20.58333268
112CDK140.58210423
113* PDK10.56193026
114PLK20.55130977
115BMX0.54981288
116RPS6KA20.54796623
117PRKG20.54529140
118MARK20.54334807
119FES0.54011053
120CDK150.53988132
121MUSK0.53910146
122CAMK40.53747497
123SIK20.53523933
124MAPKAPK30.52979227
125PTK60.52656602
126TRPM70.52595692
127ROCK20.52518887
128BRAF0.52260541
129CDK180.52127439
130JAK10.51443223
131MAPK40.51118594
132GRK60.50552125
133IRAK20.50388313
134MAP2K20.50098717
135SGK20.49846666
136PAK40.49729445
137NEK90.49266154
138MAPK130.49186085
139HIPK20.48624274
140MAPK120.48010393
141DAPK10.47665841
142MAP4K10.47654621
143CAMK2G0.47533730
144PRPF4B0.46672436
145RPS6KA30.46255014
146PTK20.44301293
147STK240.43122099
148CDK11A0.42790113
149SGK10.42028466
150MAP3K50.38655939

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.42889312
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.58181775
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25984867
4Synaptic vesicle cycle_Homo sapiens_hsa047212.18853760
5Cardiac muscle contraction_Homo sapiens_hsa042602.09055125
6* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99541933
7* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.92518576
8* Dilated cardiomyopathy_Homo sapiens_hsa054141.92408233
9Nitrogen metabolism_Homo sapiens_hsa009101.89810018
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73659468
11Propanoate metabolism_Homo sapiens_hsa006401.66566776
12* Circadian entrainment_Homo sapiens_hsa047131.62827357
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61207873
14* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58580010
15* Olfactory transduction_Homo sapiens_hsa047401.53000580
16* Insulin secretion_Homo sapiens_hsa049111.52116444
17* GABAergic synapse_Homo sapiens_hsa047271.50010194
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49731222
19Osteoclast differentiation_Homo sapiens_hsa043801.46648790
20Fatty acid degradation_Homo sapiens_hsa000711.46588919
21Acute myeloid leukemia_Homo sapiens_hsa052211.46491214
22Fatty acid metabolism_Homo sapiens_hsa012121.46115178
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43912925
24Other glycan degradation_Homo sapiens_hsa005111.43800254
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39673331
26* Long-term potentiation_Homo sapiens_hsa047201.37849105
27* Dopaminergic synapse_Homo sapiens_hsa047281.34895271
28* Gastric acid secretion_Homo sapiens_hsa049711.34856416
29Nicotine addiction_Homo sapiens_hsa050331.33595796
30Type II diabetes mellitus_Homo sapiens_hsa049301.33227827
31* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32865325
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28219462
33Carbon metabolism_Homo sapiens_hsa012001.28026292
34* Cholinergic synapse_Homo sapiens_hsa047251.25063688
35* Prion diseases_Homo sapiens_hsa050201.23022529
36B cell receptor signaling pathway_Homo sapiens_hsa046621.22791285
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22726058
38* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22587715
39* Amphetamine addiction_Homo sapiens_hsa050311.21661441
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21594426
41* Oxytocin signaling pathway_Homo sapiens_hsa049211.21491161
42* Glutamatergic synapse_Homo sapiens_hsa047241.19875112
43* Salivary secretion_Homo sapiens_hsa049701.19269064
44* Morphine addiction_Homo sapiens_hsa050321.17988398
45* Amoebiasis_Homo sapiens_hsa051461.16904582
46Pyruvate metabolism_Homo sapiens_hsa006201.15341907
47Butanoate metabolism_Homo sapiens_hsa006501.11246478
48* Glucagon signaling pathway_Homo sapiens_hsa049221.11165490
49Notch signaling pathway_Homo sapiens_hsa043301.09956952
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09257098
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09159186
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09137696
53Pentose phosphate pathway_Homo sapiens_hsa000301.09094911
54Fatty acid biosynthesis_Homo sapiens_hsa000611.08992442
55* Insulin signaling pathway_Homo sapiens_hsa049101.08013145
56* Renin secretion_Homo sapiens_hsa049241.07971838
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06172760
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.06064802
59* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06021771
60Arginine biosynthesis_Homo sapiens_hsa002201.05449344
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.05203082
62Pancreatic cancer_Homo sapiens_hsa052121.04170831
63* GnRH signaling pathway_Homo sapiens_hsa049121.02122844
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01811166
65Glioma_Homo sapiens_hsa052141.01177392
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99067361
67* Calcium signaling pathway_Homo sapiens_hsa040200.98924530
68Dorso-ventral axis formation_Homo sapiens_hsa043200.95894845
69* Gap junction_Homo sapiens_hsa045400.94745871
70PPAR signaling pathway_Homo sapiens_hsa033200.94572376
71* cAMP signaling pathway_Homo sapiens_hsa040240.93745882
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91747115
73Bladder cancer_Homo sapiens_hsa052190.91062852
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.90922847
75* Estrogen signaling pathway_Homo sapiens_hsa049150.90385005
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89127434
77Leishmaniasis_Homo sapiens_hsa051400.88087139
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86255527
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.86070749
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85859223
81Insulin resistance_Homo sapiens_hsa049310.85069779
82Tuberculosis_Homo sapiens_hsa051520.84213485
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82931246
84AMPK signaling pathway_Homo sapiens_hsa041520.82734002
85mTOR signaling pathway_Homo sapiens_hsa041500.81239171
86Choline metabolism in cancer_Homo sapiens_hsa052310.80371375
87Thyroid cancer_Homo sapiens_hsa052160.80360367
88* Proteoglycans in cancer_Homo sapiens_hsa052050.80200018
89Long-term depression_Homo sapiens_hsa047300.78750746
90Prolactin signaling pathway_Homo sapiens_hsa049170.78210568
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78105639
92* Cocaine addiction_Homo sapiens_hsa050300.77258405
93* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75452068
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.75199384
95Fructose and mannose metabolism_Homo sapiens_hsa000510.74082938
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.74050019
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73446443
98* Chemokine signaling pathway_Homo sapiens_hsa040620.73199181
99Malaria_Homo sapiens_hsa051440.73121350
100* Taste transduction_Homo sapiens_hsa047420.73035152
101* Platelet activation_Homo sapiens_hsa046110.72715608
102* Bile secretion_Homo sapiens_hsa049760.72466143
103Inositol phosphate metabolism_Homo sapiens_hsa005620.71308579
104* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69154512
105Adherens junction_Homo sapiens_hsa045200.69134548
106HIF-1 signaling pathway_Homo sapiens_hsa040660.69108173
107ErbB signaling pathway_Homo sapiens_hsa040120.69063853
108* Melanogenesis_Homo sapiens_hsa049160.68058127
109Lysosome_Homo sapiens_hsa041420.67841122
110* Vascular smooth muscle contraction_Homo sapiens_hsa042700.67765779
111ECM-receptor interaction_Homo sapiens_hsa045120.67416499
112Parkinsons disease_Homo sapiens_hsa050120.67026290
113Alzheimers disease_Homo sapiens_hsa050100.66866756
114Biosynthesis of amino acids_Homo sapiens_hsa012300.66400755
115VEGF signaling pathway_Homo sapiens_hsa043700.66352339
116Salmonella infection_Homo sapiens_hsa051320.66144297
117Toxoplasmosis_Homo sapiens_hsa051450.65623864
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.65239606
119* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64195425
120T cell receptor signaling pathway_Homo sapiens_hsa046600.63888104
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63872972
122FoxO signaling pathway_Homo sapiens_hsa040680.63120470
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62611251
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62431761
125Axon guidance_Homo sapiens_hsa043600.62086279
126Endometrial cancer_Homo sapiens_hsa052130.61913586
127* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61881491
128Staphylococcus aureus infection_Homo sapiens_hsa051500.61309454
129* Serotonergic synapse_Homo sapiens_hsa047260.58490075
130Focal adhesion_Homo sapiens_hsa045100.58051183
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57924512
132Pancreatic secretion_Homo sapiens_hsa049720.54429899
133Tight junction_Homo sapiens_hsa045300.51814887
134Collecting duct acid secretion_Homo sapiens_hsa049660.51127210
135Oxidative phosphorylation_Homo sapiens_hsa001900.47939071
136Renal cell carcinoma_Homo sapiens_hsa052110.47463327
137Starch and sucrose metabolism_Homo sapiens_hsa005000.47054593
138* Thyroid hormone synthesis_Homo sapiens_hsa049180.46060891
139Non-small cell lung cancer_Homo sapiens_hsa052230.45988001
140Endocytosis_Homo sapiens_hsa041440.43853236
141* MAPK signaling pathway_Homo sapiens_hsa040100.43623119
142Rap1 signaling pathway_Homo sapiens_hsa040150.41293658
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40287430
144Viral myocarditis_Homo sapiens_hsa054160.39752165
145* Oocyte meiosis_Homo sapiens_hsa041140.39578133

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