PRIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.96219116
2DNA deamination (GO:0045006)5.64597180
3DNA double-strand break processing (GO:0000729)5.11653295
4viral transcription (GO:0019083)5.07100017
5translational termination (GO:0006415)4.88469954
6ribosomal small subunit biogenesis (GO:0042274)4.78676077
7* telomere maintenance via semi-conservative replication (GO:0032201)4.61343930
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51029397
9protein localization to kinetochore (GO:0034501)4.45162398
10maturation of SSU-rRNA (GO:0030490)4.44336051
11cotranslational protein targeting to membrane (GO:0006613)4.42862668
12mitotic metaphase plate congression (GO:0007080)4.42750157
13protein targeting to ER (GO:0045047)4.38405380
14histone exchange (GO:0043486)4.37856912
15nuclear pore complex assembly (GO:0051292)4.37086149
16nuclear pore organization (GO:0006999)4.25937609
17* DNA strand elongation involved in DNA replication (GO:0006271)4.24413576
18DNA replication-dependent nucleosome organization (GO:0034723)4.19732997
19DNA replication-dependent nucleosome assembly (GO:0006335)4.19732997
20protein localization to endoplasmic reticulum (GO:0070972)4.19195388
21mitotic sister chromatid segregation (GO:0000070)4.18833495
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15157128
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14685100
24translational elongation (GO:0006414)4.13909389
25* DNA strand elongation (GO:0022616)4.07908038
26* telomere maintenance via recombination (GO:0000722)4.01422838
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.00713131
28sister chromatid segregation (GO:0000819)4.00111050
29protein localization to chromosome, centromeric region (GO:0071459)3.99789311
30mitotic chromosome condensation (GO:0007076)3.97796945
31regulation of centriole replication (GO:0046599)3.90814237
32metaphase plate congression (GO:0051310)3.90670110
33proteasome assembly (GO:0043248)3.87054498
34ribosomal large subunit biogenesis (GO:0042273)3.82992357
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.78832968
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.78832968
37spindle checkpoint (GO:0031577)3.78769270
38respiratory chain complex IV assembly (GO:0008535)3.76947478
39viral life cycle (GO:0019058)3.76432656
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72434986
41translational initiation (GO:0006413)3.67320666
42* DNA replication initiation (GO:0006270)3.67215085
43cellular protein complex disassembly (GO:0043624)3.65190525
44* mitotic recombination (GO:0006312)3.59511283
45mitotic G2/M transition checkpoint (GO:0044818)3.59484330
46DNA catabolic process, exonucleolytic (GO:0000738)3.59198902
47regulation of centrosome cycle (GO:0046605)3.57482942
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.56567414
49positive regulation of chromosome segregation (GO:0051984)3.52744818
50lymphoid progenitor cell differentiation (GO:0002320)3.52412128
51mitotic spindle checkpoint (GO:0071174)3.51422048
52double-strand break repair via nonhomologous end joining (GO:0006303)3.49699453
53non-recombinational repair (GO:0000726)3.49699453
54negative regulation of chromosome segregation (GO:0051985)3.49634398
55regulation of chromosome segregation (GO:0051983)3.47652418
56IMP biosynthetic process (GO:0006188)3.47072207
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45453635
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.45453635
59negative regulation of sister chromatid segregation (GO:0033046)3.45453635
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45453635
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45453635
62* telomere maintenance via telomere lengthening (GO:0010833)3.43762406
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43648476
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43648476
65pseudouridine synthesis (GO:0001522)3.43488872
66DNA replication checkpoint (GO:0000076)3.41895015
67postreplication repair (GO:0006301)3.41043294
68mitotic nuclear envelope disassembly (GO:0007077)3.40728051
69heterochromatin organization (GO:0070828)3.37173636
70regulation of sister chromatid segregation (GO:0033045)3.36694270
71regulation of mitotic sister chromatid separation (GO:0010965)3.36694270
72regulation of mitotic sister chromatid segregation (GO:0033047)3.36694270
73replication fork processing (GO:0031297)3.35571694
74establishment of chromosome localization (GO:0051303)3.32499256
75regulation of helicase activity (GO:0051095)3.31837741
76platelet dense granule organization (GO:0060155)3.31810159
77mitotic spindle assembly checkpoint (GO:0007094)3.29529751
78CENP-A containing nucleosome assembly (GO:0034080)3.28441431
79mitotic sister chromatid cohesion (GO:0007064)3.28282073
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.26927254
81spindle assembly checkpoint (GO:0071173)3.26451919
82pore complex assembly (GO:0046931)3.24660428
83protein complex disassembly (GO:0043241)3.20034900
84chromatin assembly or disassembly (GO:0006333)3.19046013
85ribonucleoprotein complex biogenesis (GO:0022613)3.18951667
86double-strand break repair via homologous recombination (GO:0000724)3.16907292
87recombinational repair (GO:0000725)3.16199289
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15530717
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15530717
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.15530717
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13340852
92chromatin remodeling at centromere (GO:0031055)3.12817075
93translation (GO:0006412)3.12695203
94regulation of centrosome duplication (GO:0010824)3.12643103
95transcription elongation from RNA polymerase III promoter (GO:0006385)3.08926585
96termination of RNA polymerase III transcription (GO:0006386)3.08926585
97IMP metabolic process (GO:0046040)3.08772470
98nuclear envelope disassembly (GO:0051081)3.07160993
99membrane disassembly (GO:0030397)3.07160993
100translesion synthesis (GO:0019985)3.07083395
101synapsis (GO:0007129)3.06405200
102chromosome segregation (GO:0007059)3.04189397
103macromolecular complex disassembly (GO:0032984)3.03871541
104mitotic G2 DNA damage checkpoint (GO:0007095)3.02345326
105cytochrome complex assembly (GO:0017004)3.02126375
106purine nucleobase biosynthetic process (GO:0009113)3.01650307
107nuclear-transcribed mRNA catabolic process (GO:0000956)3.00609928
108mannosylation (GO:0097502)2.99991377
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99923002
110regulation of mitotic spindle checkpoint (GO:1903504)2.99923002
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99766253
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97507872
113rRNA processing (GO:0006364)2.94940152
114centriole replication (GO:0007099)2.94640265
115nucleobase biosynthetic process (GO:0046112)2.94572268
116mRNA cleavage (GO:0006379)2.94339807
117regulation of DNA endoreduplication (GO:0032875)2.93486655
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92992470
119mRNA catabolic process (GO:0006402)2.91667315
120response to interferon-beta (GO:0035456)2.91252897
121tRNA methylation (GO:0030488)2.90181749
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87423248
123transcription-coupled nucleotide-excision repair (GO:0006283)2.85940536
124tRNA modification (GO:0006400)2.84557196
125rRNA metabolic process (GO:0016072)2.83244985
126DNA ligation (GO:0006266)2.82398027
127RNA catabolic process (GO:0006401)2.79931936
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79314105
129intra-S DNA damage checkpoint (GO:0031573)2.78899651
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.76642863
131negative regulation of transcription by competitive promoter binding (GO:0010944)2.76488714
132DNA replication-independent nucleosome organization (GO:0034724)2.72044451
133DNA replication-independent nucleosome assembly (GO:0006336)2.72044451
134protein targeting to membrane (GO:0006612)2.70951499
135cellular component biogenesis (GO:0044085)2.69436473
136GPI anchor biosynthetic process (GO:0006506)2.69308760
137ribosome assembly (GO:0042255)2.68844167
138pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67925727
139kinetochore assembly (GO:0051382)2.66880770
140deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66022367
141pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64354339
142kinetochore organization (GO:0051383)2.60365028
143DNA-dependent DNA replication (GO:0006261)2.60026315
144DNA unwinding involved in DNA replication (GO:0006268)2.57909491
145* telomere maintenance (GO:0000723)2.57810118
146regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57789701
147* telomere organization (GO:0032200)2.57188941
148spliceosomal snRNP assembly (GO:0000387)2.54283789
149establishment of integrated proviral latency (GO:0075713)2.53110290
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.52303179
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51969506
152C-terminal protein lipidation (GO:0006501)2.50801731
153GDP-mannose metabolic process (GO:0019673)2.50354076
154iron-sulfur cluster assembly (GO:0016226)2.50303053
155metallo-sulfur cluster assembly (GO:0031163)2.50303053
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50029897
157facial nerve structural organization (GO:0021612)2.48982131
158dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.48611139
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48498938
160somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48498938
161isotype switching (GO:0045190)2.48498938
162definitive hemopoiesis (GO:0060216)2.48080991
163deoxyribonucleotide catabolic process (GO:0009264)2.46926556
164viral mRNA export from host cell nucleus (GO:0046784)2.46780750
165negative regulation of myotube differentiation (GO:0010832)2.46046345
166ncRNA processing (GO:0034470)2.44361189
167RNA capping (GO:0036260)2.43169900
1687-methylguanosine RNA capping (GO:0009452)2.43169900
169DNA damage response, detection of DNA damage (GO:0042769)2.42900063
170antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42744743
1717-methylguanosine mRNA capping (GO:0006370)2.42725031
172tRNA processing (GO:0008033)2.41868770
173immunoglobulin mediated immune response (GO:0016064)2.41849456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.20938494
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.45302222
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08750725
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.74311422
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49485641
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39928009
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.22937000
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11485314
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08958028
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99679882
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99184685
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96096308
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87108797
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72072524
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70987479
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.62644327
17VDR_23849224_ChIP-Seq_CD4+_Human2.51919101
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51129008
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45924319
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.40143697
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.40120104
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.36291925
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35504703
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34275899
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.31453735
26SCL_19346495_ChIP-Seq_HPC-7_Human2.23808658
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23208238
28ERG_20887958_ChIP-Seq_HPC-7_Mouse2.21303009
29FOXP3_21729870_ChIP-Seq_TREG_Human2.18857319
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18086099
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14311572
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12941795
33CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12188467
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09687587
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08269224
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07255449
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06025488
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96215195
39* SRF_21415370_ChIP-Seq_HL-1_Mouse1.94250457
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92922268
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87976485
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.87352409
43DCP1A_22483619_ChIP-Seq_HELA_Human1.82067860
44ELK1_19687146_ChIP-ChIP_HELA_Human1.82041928
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81475036
46XRN2_22483619_ChIP-Seq_HELA_Human1.81378760
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77606297
48* SPI1_23547873_ChIP-Seq_NB4_Human1.76288930
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75344254
50* EWS_26573619_Chip-Seq_HEK293_Human1.74176078
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73514010
52TTF2_22483619_ChIP-Seq_HELA_Human1.73323500
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.67948136
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65534914
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65453278
56* FUS_26573619_Chip-Seq_HEK293_Human1.63274068
57GABP_19822575_ChIP-Seq_HepG2_Human1.60207198
58IRF1_19129219_ChIP-ChIP_H3396_Human1.53625310
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52866375
60ZNF274_21170338_ChIP-Seq_K562_Hela1.52453195
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50500227
62* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49178465
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.48067283
64CIITA_25753668_ChIP-Seq_RAJI_Human1.41838278
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38326632
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38045525
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34386666
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32864450
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31097616
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30891945
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28256887
72MYC_18940864_ChIP-ChIP_HL60_Human1.27696820
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27656768
74VDR_21846776_ChIP-Seq_THP-1_Human1.25387174
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.25239057
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23362724
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.23334357
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23093241
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20964347
80* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20695835
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20424302
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20354075
83* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18447808
84KDM5A_27292631_Chip-Seq_BREAST_Human1.13223890
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10620653
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09638972
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.09305994
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.09183634
89MYB_26560356_Chip-Seq_TH2_Human1.09115590
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08561056
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05886102
92* IGF1R_20145208_ChIP-Seq_DFB_Human1.04261139
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.04206671
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.03721704
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.03624460
96VDR_22108803_ChIP-Seq_LS180_Human1.02017039
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.00544863
98VDR_24763502_ChIP-Seq_THP-1_Human1.00261340
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98064062
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97913757
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97018758
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96311064
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96021558
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95597661
105MYC_22102868_ChIP-Seq_BL_Human0.95274728
106GATA1_22025678_ChIP-Seq_K562_Human0.92906406
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92364242
108MYB_26560356_Chip-Seq_TH1_Human0.92198406
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91714829
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91486423
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90730069
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89345742
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88783504
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.87060736
115* P300_19829295_ChIP-Seq_ESCs_Human0.86362990
116RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85622638
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85384888
118AR_21909140_ChIP-Seq_LNCAP_Human0.85092716
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82943645
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81683532
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79673491
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79661902
123MAF_26560356_Chip-Seq_TH1_Human0.79578074
124* FLI1_27457419_Chip-Seq_LIVER_Mouse0.79070937
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78338314
126* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77178177
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75298839
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75087863
129CBP_20019798_ChIP-Seq_JUKART_Human0.74642819
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74642819
131ELF5_23300383_ChIP-Seq_T47D_Human0.73926356
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72948361
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71119390
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68001377
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.66746571
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66741717
137* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.65050340
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.64805824
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64583707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.07422005
2MP0005174_abnormal_tail_pigmentation3.32439405
3MP0009697_abnormal_copulation3.18756610
4MP0002396_abnormal_hematopoietic_system3.11540461
5MP0003693_abnormal_embryo_hatching3.05005651
6MP0001188_hyperpigmentation2.98479104
7MP0006292_abnormal_olfactory_placode2.90047696
8MP0003806_abnormal_nucleotide_metabolis2.86810672
9MP0008058_abnormal_DNA_repair2.84359876
10MP0005409_darkened_coat_color2.81356093
11MP0010094_abnormal_chromosome_stability2.80134944
12MP0000015_abnormal_ear_pigmentation2.74903624
13MP0005075_abnormal_melanosome_morpholog2.72440773
14MP0008057_abnormal_DNA_replication2.38307787
15MP0001835_abnormal_antigen_presentation2.36926168
16MP0000490_abnormal_crypts_of2.34945217
17MP0002095_abnormal_skin_pigmentation2.27355047
18MP0003136_yellow_coat_color2.16354208
19MP0009785_altered_susceptibility_to2.13962750
20MP0005671_abnormal_response_to2.13331295
21MP0003763_abnormal_thymus_physiology2.13285439
22MP0008007_abnormal_cellular_replicative2.12164598
23MP0003890_abnormal_embryonic-extraembry2.05429574
24MP0001986_abnormal_taste_sensitivity2.04518919
25MP0003077_abnormal_cell_cycle2.00000616
26MP0003724_increased_susceptibility_to1.97437168
27MP0003111_abnormal_nucleus_morphology1.94655043
28MP0004957_abnormal_blastocyst_morpholog1.89607375
29MP0000372_irregular_coat_pigmentation1.84667646
30MP0004381_abnormal_hair_follicle1.83940228
31MP0009333_abnormal_splenocyte_physiolog1.82247063
32MP0008260_abnormal_autophagy1.81655344
33MP0003941_abnormal_skin_development1.77673013
34MP0002148_abnormal_hypersensitivity_rea1.76000020
35MP0000685_abnormal_immune_system1.75018960
36MP0010352_gastrointestinal_tract_polyps1.74622402
37MP0004147_increased_porphyrin_level1.72238134
38MP0005025_abnormal_response_to1.72074016
39MP0002398_abnormal_bone_marrow1.68731014
40MP0000465_gastrointestinal_hemorrhage1.68692107
41MP0010307_abnormal_tumor_latency1.67057716
42MP0003786_premature_aging1.65838188
43MP0003937_abnormal_limbs/digits/tail_de1.65181403
44MP0001730_embryonic_growth_arrest1.63511327
45MP0001545_abnormal_hematopoietic_system1.63411575
46MP0005397_hematopoietic_system_phenotyp1.63411575
47MP0001293_anophthalmia1.61415430
48MP0002420_abnormal_adaptive_immunity1.56451740
49MP0005000_abnormal_immune_tolerance1.54945680
50MP0006072_abnormal_retinal_apoptosis1.53211862
51MP0001819_abnormal_immune_cell1.53152640
52MP0002723_abnormal_immune_serum1.51822844
53MP0001800_abnormal_humoral_immune1.51079839
54MP0004808_abnormal_hematopoietic_stem1.48274139
55MP0002132_abnormal_respiratory_system1.48135016
56MP0005380_embryogenesis_phenotype1.46484279
57MP0001672_abnormal_embryogenesis/_devel1.46484279
58MP0006035_abnormal_mitochondrial_morpho1.46474474
59MP0002452_abnormal_antigen_presenting1.44752744
60MP0000681_abnormal_thyroid_gland1.44154118
61MP0000689_abnormal_spleen_morphology1.42726647
62MP0001853_heart_inflammation1.41822725
63MP0001697_abnormal_embryo_size1.41611535
64MP0000716_abnormal_immune_system1.40782649
65MP0002166_altered_tumor_susceptibility1.39424900
66MP0002722_abnormal_immune_system1.36903522
67MP0003436_decreased_susceptibility_to1.34760412
68MP0001529_abnormal_vocalization1.34692710
69MP0002419_abnormal_innate_immunity1.33968630
70MP0002429_abnormal_blood_cell1.32473452
71MP0008932_abnormal_embryonic_tissue1.31354008
72MP0002006_tumorigenesis1.29227436
73MP0001661_extended_life_span1.29137157
74MP0002084_abnormal_developmental_patter1.28227269
75MP0008789_abnormal_olfactory_epithelium1.26332116
76MP0002085_abnormal_embryonic_tissue1.24773859
77MP0002233_abnormal_nose_morphology1.22463617
78MP0002009_preneoplasia1.20744829
79MP0003984_embryonic_growth_retardation1.20618454
80MP0005464_abnormal_platelet_physiology1.20443450
81MP0002088_abnormal_embryonic_growth/wei1.18479047
82MP0004197_abnormal_fetal_growth/weight/1.17004406
83MP0002080_prenatal_lethality1.13221812
84MP0002019_abnormal_tumor_incidence1.12721263
85MP0000703_abnormal_thymus_morphology1.12282624
86MP0005410_abnormal_fertilization1.10415964
87MP0002102_abnormal_ear_morphology1.09929025
88MP0002938_white_spotting1.09626316
89MP0010030_abnormal_orbit_morphology1.09291232
90MP0001873_stomach_inflammation1.06067479
91MP0003866_abnormal_defecation1.06060954
92MP0000653_abnormal_sex_gland1.05805429
93MP0010155_abnormal_intestine_physiology1.04720092
94MP0005389_reproductive_system_phenotype1.03923974
95MP0005387_immune_system_phenotype1.03471587
96MP0001790_abnormal_immune_system1.03471587
97MP0005187_abnormal_penis_morphology1.01543987
98MP0002405_respiratory_system_inflammati1.01233126
99MP0005083_abnormal_biliary_tract1.00892790
100MP0005395_other_phenotype1.00080957
101MP0000049_abnormal_middle_ear1.00008565
102MP0000358_abnormal_cell_content/0.98498921
103MP0003718_maternal_effect0.97555492
104MP0002177_abnormal_outer_ear0.96857459
105MP0005499_abnormal_olfactory_system0.96025765
106MP0005394_taste/olfaction_phenotype0.96025765
107MP0000537_abnormal_urethra_morphology0.94832617
108MP0002075_abnormal_coat/hair_pigmentati0.93487781
109MP0003755_abnormal_palate_morphology0.93469338
110MP0003119_abnormal_digestive_system0.92836550
111MP0003698_abnormal_male_reproductive0.92304758
112MP0003315_abnormal_perineum_morphology0.90424613
113MP0000313_abnormal_cell_death0.90058714
114MP0009250_abnormal_appendicular_skeleto0.89908277
115MP0006054_spinal_hemorrhage0.89856286
116MP0003950_abnormal_plasma_membrane0.89739926
117MP0002086_abnormal_extraembryonic_tissu0.89334919
118MP0001286_abnormal_eye_development0.88862067
119MP0000858_altered_metastatic_potential0.87679254
120MP0000383_abnormal_hair_follicle0.87238278
121MP0003121_genomic_imprinting0.87194098
122MP0002210_abnormal_sex_determination0.86368541
123MP0010678_abnormal_skin_adnexa0.84356889
124MP0008995_early_reproductive_senescence0.84263940
125MP0002751_abnormal_autonomic_nervous0.84043238
126MP0005084_abnormal_gallbladder_morpholo0.83396230
127MP0002234_abnormal_pharynx_morphology0.82581922
128MP0006036_abnormal_mitochondrial_physio0.82000472
129MP0001186_pigmentation_phenotype0.81654398
130MP0003186_abnormal_redox_activity0.81217589
131MP0002111_abnormal_tail_morphology0.80943120
132MP0000427_abnormal_hair_cycle0.80126752
133MP0001845_abnormal_inflammatory_respons0.77950171
134MP0009672_abnormal_birth_weight0.77101535
135MP0000566_synostosis0.77099440
136MP0000428_abnormal_craniofacial_morphol0.77048859
137MP0003646_muscle_fatigue0.76677103
138MP0003936_abnormal_reproductive_system0.76567166
139MP0003699_abnormal_female_reproductive0.76499529
140MP0001299_abnormal_eye_distance/0.76488358
141MP0003935_abnormal_craniofacial_develop0.76362132
142MP0002277_abnormal_respiratory_mucosa0.75560409
143MP0008877_abnormal_DNA_methylation0.75140732
144MP0000678_abnormal_parathyroid_gland0.75103680
145MP0002161_abnormal_fertility/fecundity0.73251621
146MP0002092_abnormal_eye_morphology0.72922625
147MP0002160_abnormal_reproductive_system0.71659460
148MP0004272_abnormal_basement_membrane0.70894289
149MP0003938_abnormal_ear_development0.70769798
150MP0005391_vision/eye_phenotype0.70153433
151MP0003385_abnormal_body_wall0.70034703
152MP0002697_abnormal_eye_size0.69431857
153MP0001119_abnormal_female_reproductive0.68907735
154MP0000613_abnormal_salivary_gland0.68848859
155MP0005367_renal/urinary_system_phenotyp0.68676819
156MP0000516_abnormal_urinary_system0.68676819
157MP0003567_abnormal_fetal_cardiomyocyte0.68585674
158MP0002254_reproductive_system_inflammat0.68531904
159MP0000350_abnormal_cell_proliferation0.67114705
160MP0008469_abnormal_protein_level0.67065666
161MP0001145_abnormal_male_reproductive0.66845416
162MP0001929_abnormal_gametogenesis0.66636365
163MP0003656_abnormal_erythrocyte_physiolo0.66204847
164MP0002876_abnormal_thyroid_physiology0.66123869
165MP0008770_decreased_survivor_rate0.64988085
166MP0004142_abnormal_muscle_tone0.64621523

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.84576406
2Reduced antithrombin III activity (HP:0001976)5.58271087
3Abnormal number of erythroid precursors (HP:0012131)5.12332366
4Abnormality of cells of the erythroid lineage (HP:0012130)5.11570584
5Reticulocytopenia (HP:0001896)4.53126255
6Aplastic anemia (HP:0001915)4.42930609
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.20409551
8Abnormal protein N-linked glycosylation (HP:0012347)4.20409551
9Abnormal protein glycosylation (HP:0012346)4.20409551
10Abnormal glycosylation (HP:0012345)4.20409551
11Abnormality of the labia minora (HP:0012880)3.39442811
12Thrombocytosis (HP:0001894)3.31970687
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22320827
14Pallor (HP:0000980)3.21357018
15Elevated erythrocyte sedimentation rate (HP:0003565)3.14173684
16Hypothermia (HP:0002045)3.13839355
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.12970469
18Severe visual impairment (HP:0001141)3.12694339
19Macrocytic anemia (HP:0001972)3.11026521
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09137145
21Birth length less than 3rd percentile (HP:0003561)3.05552408
22Colon cancer (HP:0003003)3.04628919
23Abnormal lung lobation (HP:0002101)2.97910544
24Abnormality of the carotid arteries (HP:0005344)2.97410923
25Abnormality of the duodenum (HP:0002246)2.95153482
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91140557
27Sloping forehead (HP:0000340)2.90643852
28IgM deficiency (HP:0002850)2.90504946
29Thyroid-stimulating hormone excess (HP:0002925)2.90081703
30Chromsome breakage (HP:0040012)2.88767342
31Nephroblastoma (Wilms tumor) (HP:0002667)2.85111062
32Increased hepatocellular lipid droplets (HP:0006565)2.85072113
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83579947
34Petechiae (HP:0000967)2.75515691
35Absent radius (HP:0003974)2.73674507
36Embryonal renal neoplasm (HP:0011794)2.73639549
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72043546
38Type 2 muscle fiber atrophy (HP:0003554)2.70039003
39Exertional dyspnea (HP:0002875)2.69345092
40Hepatocellular necrosis (HP:0001404)2.66132405
41Muscle fiber atrophy (HP:0100295)2.61151918
42Ectopic kidney (HP:0000086)2.60433293
43Pancytopenia (HP:0001876)2.59012224
44Absent forearm bone (HP:0003953)2.58106658
45Aplasia involving forearm bones (HP:0009822)2.58106658
46Facial hemangioma (HP:0000329)2.57015918
47Median cleft lip (HP:0000161)2.54981294
48Abnormality of the columella (HP:0009929)2.52169609
49Myositis (HP:0100614)2.51848318
50Abnormality of the preputium (HP:0100587)2.49791466
51Microvesicular hepatic steatosis (HP:0001414)2.46934310
52Medulloblastoma (HP:0002885)2.45560203
53Volvulus (HP:0002580)2.44992001
543-Methylglutaconic aciduria (HP:0003535)2.44438617
55Renal Fanconi syndrome (HP:0001994)2.43026577
56Nonprogressive disorder (HP:0003680)2.41766068
57Sensory axonal neuropathy (HP:0003390)2.41183002
58Ependymoma (HP:0002888)2.38968433
59Supernumerary spleens (HP:0009799)2.36607143
60Abnormality of chromosome stability (HP:0003220)2.34524301
61Meckel diverticulum (HP:0002245)2.33596332
62Lipid accumulation in hepatocytes (HP:0006561)2.32592039
63Abnormality of the prostate (HP:0008775)2.27639697
64Abnormality of the ileum (HP:0001549)2.27606226
65Recurrent abscess formation (HP:0002722)2.26579392
66Rhabdomyosarcoma (HP:0002859)2.25934590
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23716040
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23716040
69True hermaphroditism (HP:0010459)2.21348514
70Small hand (HP:0200055)2.20822304
71Meningitis (HP:0001287)2.18727014
72Hepatic necrosis (HP:0002605)2.18549831
73Horseshoe kidney (HP:0000085)2.17916025
74Prolonged bleeding time (HP:0003010)2.17833948
75Clubbing of toes (HP:0100760)2.16772485
76Myelodysplasia (HP:0002863)2.16675797
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.15976834
78Duplicated collecting system (HP:0000081)2.14243263
79Chronic otitis media (HP:0000389)2.14167170
80Abnormality of DNA repair (HP:0003254)2.12489744
81Cerebellar dysplasia (HP:0007033)2.12481182
82Bone marrow hypocellularity (HP:0005528)2.12477801
83Short thumb (HP:0009778)2.10310872
84Abnormality of T cell physiology (HP:0011840)2.09291584
85Lymphoma (HP:0002665)2.08874635
86Carpal bone hypoplasia (HP:0001498)2.07992806
87Glioma (HP:0009733)2.06861300
88Abnormal rod and cone electroretinograms (HP:0008323)2.04027201
89Mitochondrial inheritance (HP:0001427)2.03209488
90Oral leukoplakia (HP:0002745)2.03203020
91Chronic obstructive pulmonary disease (HP:0006510)2.02775210
92Obstructive lung disease (HP:0006536)2.02775210
93Attenuation of retinal blood vessels (HP:0007843)1.99792334
94IgG deficiency (HP:0004315)1.97684633
95Increased nuchal translucency (HP:0010880)1.96919957
96Pulmonary fibrosis (HP:0002206)1.96608150
97Neoplasm of the colon (HP:0100273)1.94823627
98Microcytic anemia (HP:0001935)1.94640597
99Capillary hemangiomas (HP:0005306)1.93010858
100Arteriovenous malformation (HP:0100026)1.90937259
101Panhypogammaglobulinemia (HP:0003139)1.90185720
102Pancreatic islet-cell hyperplasia (HP:0004510)1.90065496
103Triphalangeal thumb (HP:0001199)1.89432515
104Respiratory difficulties (HP:0002880)1.89422873
105Choanal atresia (HP:0000453)1.88819033
106Increased intramyocellular lipid droplets (HP:0012240)1.88358293
107Abnormality of the axillary hair (HP:0100134)1.88278037
108Abnormality of secondary sexual hair (HP:0009888)1.88278037
109Increased serum lactate (HP:0002151)1.88174568
11011 pairs of ribs (HP:0000878)1.87661056
111Absent thumb (HP:0009777)1.87287934
112Abnormal spermatogenesis (HP:0008669)1.86109323
113Pancreatic cysts (HP:0001737)1.85202614
114Breast carcinoma (HP:0003002)1.84995259
115Premature graying of hair (HP:0002216)1.84343981
116B lymphocytopenia (HP:0010976)1.83205692
117Abnormality of B cell number (HP:0010975)1.83205692
118Acute lymphatic leukemia (HP:0006721)1.82950115
119Cafe-au-lait spot (HP:0000957)1.82836414
120Pancreatic fibrosis (HP:0100732)1.82234800
121Abnormality of the astrocytes (HP:0100707)1.81505392
122Astrocytoma (HP:0009592)1.81505392
123High anterior hairline (HP:0009890)1.80099399
124Increased CSF lactate (HP:0002490)1.79896484
125Amaurosis fugax (HP:0100576)1.79507432
126Dry hair (HP:0011359)1.78739720
127Abnormality of the renal collecting system (HP:0004742)1.78715454
128Abnormality of methionine metabolism (HP:0010901)1.76284154
129Broad face (HP:0000283)1.75822884
130Patellar aplasia (HP:0006443)1.75255928
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74668856
132Abnormality of alanine metabolism (HP:0010916)1.74668856
133Hyperalaninemia (HP:0003348)1.74668856
134Hypoplasia of the pons (HP:0012110)1.73860628
135Aplasia/Hypoplasia of the patella (HP:0006498)1.73632993
136Stomatitis (HP:0010280)1.73014063
137Mediastinal lymphadenopathy (HP:0100721)1.72928870
138Recurrent bacterial skin infections (HP:0005406)1.72656348
139Agammaglobulinemia (HP:0004432)1.72262692
140Biliary tract neoplasm (HP:0100574)1.72221543
141Intestinal atresia (HP:0011100)1.72162963
142Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71890028
143Poikiloderma (HP:0001029)1.71221757
144High pitched voice (HP:0001620)1.70984701
145Neutropenia (HP:0001875)1.70324591
146Microretrognathia (HP:0000308)1.70164719
147Squamous cell carcinoma (HP:0002860)1.69102497
148Small intestinal stenosis (HP:0012848)1.68862627
149Duodenal stenosis (HP:0100867)1.68862627
150Neoplasm of the adrenal cortex (HP:0100641)1.68836589
151Recurrent bronchitis (HP:0002837)1.67651080
152Embryonal neoplasm (HP:0002898)1.65683616
153Bifid tongue (HP:0010297)1.64930273
154Benign neoplasm of the central nervous system (HP:0100835)1.64131178
155Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63991262
156Dandy-Walker malformation (HP:0001305)1.63622781
157Facial cleft (HP:0002006)1.62436477
158Abnormality of the pons (HP:0007361)1.61447286
159Impulsivity (HP:0100710)1.59361373
160Duplication of thumb phalanx (HP:0009942)1.59353739
161Preaxial hand polydactyly (HP:0001177)1.58957843
162Abnormality of cochlea (HP:0000375)1.58939841
163Short middle phalanx of the 5th finger (HP:0004220)1.58748086
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.57980863
165Short tibia (HP:0005736)1.57451620
166Neoplasm of the oral cavity (HP:0100649)1.56206134
167Oligohydramnios (HP:0001562)1.55920065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.28196732
2EIF2AK34.25047292
3PBK4.11662815
4STK163.94383325
5NME23.09468307
6WEE12.93276531
7NLK2.79600353
8MKNK22.69058107
9MUSK2.46752402
10MKNK12.33471235
11PLK32.21433166
12NEK12.19147095
13VRK12.18595850
14KIT2.10539335
15TEC2.06705447
16TLK12.01506213
17IRAK41.98903993
18CASK1.90126076
19SRPK11.86348995
20EIF2AK21.86133135
21TAF11.83038803
22LATS11.82498310
23VRK21.76851581
24BUB11.72316152
25PINK11.71898295
26PIM21.66896616
27CDC71.66598978
28NUAK11.61196167
29CDK191.54804805
30EIF2AK11.54225693
31FRK1.53101626
32MARK31.46135771
33CLK11.44714080
34BRSK21.44517620
35IRAK31.43316711
36ACVR1B1.42188411
37STK38L1.38195966
38CAMKK21.36098098
39FLT31.33073985
40BTK1.32151252
41DYRK31.29216523
42CSNK1A1L1.28743456
43MAP4K11.28106588
44YES11.24846964
45TXK1.19757362
46BLK1.19433661
47TRIM281.15764841
48STK31.11631728
49CDK71.09075972
50FES1.04339439
51MELK0.98073958
52ATM0.97340344
53MAP4K20.96539192
54CSF1R0.96023841
55CCNB10.94036796
56PNCK0.92379247
57ADRBK20.91902111
58PLK40.91504768
59PIM10.91101344
60CDK80.90988828
61PLK20.90181159
62MAPKAPK50.88782637
63TSSK60.87170900
64CSNK1G20.85797283
65MAP3K120.83546654
66WNK30.83377418
67ATR0.81517878
68IKBKB0.80929033
69MST40.80418154
70CHEK10.80066207
71STK390.78892025
72LYN0.77128474
73ZAK0.76882749
74ZAP700.76602701
75IKBKE0.75464090
76MAP2K70.74788964
77KDR0.74037583
78CAMK10.73551914
79SYK0.72763817
80BMPR1B0.68274091
81RPS6KB20.67923501
82TGFBR10.67093576
83CDK40.66601229
84PLK10.65088309
85MYLK0.64664528
86ERBB40.62570849
87NEK20.61437920
88PRKD20.60134347
89MATK0.59552141
90AURKB0.58558058
91TBK10.56290077
92JAK30.55708437
93ERBB30.55168771
94CSNK1G10.53706179
95NME10.53673987
96BCR0.53316511
97TESK20.53125438
98MAP3K80.53039286
99LCK0.52703805
100MAP2K30.52666191
101RPS6KA40.52069062
102RPS6KA50.50763704
103CDK10.50478826
104OXSR10.49644607
105CHEK20.49530514
106IRAK10.49399831
107CSNK2A10.49013898
108PASK0.46350982
109CDK30.45732085
110MAPK40.45651538
111CDK90.44983892
112BRSK10.44532443
113MET0.42096690
114MAP3K100.41847358
115TIE10.41329777
116MAP3K140.41180215
117CSNK2A20.40937734
118GRK10.40442806
119TGFBR20.39907390
120HIPK20.39618999
121CDK20.39193615
122MST1R0.38852589
123AURKA0.38804693
124BRAF0.37697589
125TAOK20.37578557
126RPS6KB10.37540796
127TYK20.36481383
128DYRK20.36477620
129TAOK30.35970915
130MAP3K60.35394999
131PRKG20.35320874
132MAP3K40.35044110
133IRAK20.34661779
134STK40.31286893
135PAK40.31232516
136BRD40.30848715
137AKT20.30572415
138PAK10.29996709
139TTK0.29737484
140CSNK1E0.29729985
141GRK70.29671330
142WNK40.29516467
143SCYL20.27622329
144CSNK1G30.27274165
145CSNK1D0.26063639
146TNK20.24849559
147MAPK130.24843539
148PRKDC0.23852860
149FGFR20.23789200
150RPS6KA60.22530241

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030304.65109107
2Ribosome_Homo sapiens_hsa030104.55550996
3Mismatch repair_Homo sapiens_hsa034303.73112581
4Homologous recombination_Homo sapiens_hsa034403.32374366
5Base excision repair_Homo sapiens_hsa034102.89405847
6RNA polymerase_Homo sapiens_hsa030202.84145202
7Nucleotide excision repair_Homo sapiens_hsa034202.62209707
8Spliceosome_Homo sapiens_hsa030402.51864975
9Proteasome_Homo sapiens_hsa030502.47368800
10Protein export_Homo sapiens_hsa030602.38212906
11* Pyrimidine metabolism_Homo sapiens_hsa002402.37374407
12Fanconi anemia pathway_Homo sapiens_hsa034602.35397820
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20884055
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16207217
15Non-homologous end-joining_Homo sapiens_hsa034502.14070262
16Basal transcription factors_Homo sapiens_hsa030221.88904816
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.84977630
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62861613
19Cell cycle_Homo sapiens_hsa041101.61606570
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59605153
21Propanoate metabolism_Homo sapiens_hsa006401.54670085
22Primary immunodeficiency_Homo sapiens_hsa053401.48854927
23RNA degradation_Homo sapiens_hsa030181.48436442
24Selenocompound metabolism_Homo sapiens_hsa004501.48355485
25One carbon pool by folate_Homo sapiens_hsa006701.45496449
26RNA transport_Homo sapiens_hsa030131.41751005
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39286398
28* Purine metabolism_Homo sapiens_hsa002301.38870143
29N-Glycan biosynthesis_Homo sapiens_hsa005101.35802332
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35259589
31Oocyte meiosis_Homo sapiens_hsa041141.33955053
32Herpes simplex infection_Homo sapiens_hsa051681.22756496
33Other glycan degradation_Homo sapiens_hsa005111.18814511
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18790413
35p53 signaling pathway_Homo sapiens_hsa041151.16066847
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14196383
37Thyroid cancer_Homo sapiens_hsa052161.13648693
38Pyruvate metabolism_Homo sapiens_hsa006201.10603732
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08931462
40Folate biosynthesis_Homo sapiens_hsa007901.06780654
41Measles_Homo sapiens_hsa051621.04561532
42Hematopoietic cell lineage_Homo sapiens_hsa046401.03030796
43Systemic lupus erythematosus_Homo sapiens_hsa053221.00326940
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99726597
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.98873070
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96591470
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.96345436
48Olfactory transduction_Homo sapiens_hsa047400.95420229
49Antigen processing and presentation_Homo sapiens_hsa046120.94834811
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92223760
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90200679
52Sulfur relay system_Homo sapiens_hsa041220.89611310
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89491508
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87212405
55Allograft rejection_Homo sapiens_hsa053300.86764778
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86584073
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86536445
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84834459
59Epstein-Barr virus infection_Homo sapiens_hsa051690.83950530
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82546159
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82321523
62Asthma_Homo sapiens_hsa053100.79381204
63Oxidative phosphorylation_Homo sapiens_hsa001900.77331458
64Vitamin B6 metabolism_Homo sapiens_hsa007500.76776369
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76001916
66Leishmaniasis_Homo sapiens_hsa051400.75171929
67Arachidonic acid metabolism_Homo sapiens_hsa005900.73898451
68TGF-beta signaling pathway_Homo sapiens_hsa043500.71441073
69Parkinsons disease_Homo sapiens_hsa050120.70670855
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69573351
71Hedgehog signaling pathway_Homo sapiens_hsa043400.69172258
72Sphingolipid metabolism_Homo sapiens_hsa006000.68288610
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67771379
74Basal cell carcinoma_Homo sapiens_hsa052170.67047930
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66968361
76Butanoate metabolism_Homo sapiens_hsa006500.66294592
77Biosynthesis of amino acids_Homo sapiens_hsa012300.65767738
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65594712
79Huntingtons disease_Homo sapiens_hsa050160.64759639
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63925681
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63263724
82Steroid biosynthesis_Homo sapiens_hsa001000.60207582
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60201087
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58885935
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.58611863
86Acute myeloid leukemia_Homo sapiens_hsa052210.57224030
87Graft-versus-host disease_Homo sapiens_hsa053320.56918289
88Hippo signaling pathway_Homo sapiens_hsa043900.55175268
89Pentose phosphate pathway_Homo sapiens_hsa000300.52293210
90mRNA surveillance pathway_Homo sapiens_hsa030150.51679056
91Wnt signaling pathway_Homo sapiens_hsa043100.49657617
92B cell receptor signaling pathway_Homo sapiens_hsa046620.47902067
93Carbon metabolism_Homo sapiens_hsa012000.47672879
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46827646
95Legionellosis_Homo sapiens_hsa051340.46757892
96Influenza A_Homo sapiens_hsa051640.46212124
97Malaria_Homo sapiens_hsa051440.45060521
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44501832
99Viral carcinogenesis_Homo sapiens_hsa052030.44222523
100Autoimmune thyroid disease_Homo sapiens_hsa053200.44033448
101Regulation of autophagy_Homo sapiens_hsa041400.41371756
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41290727
103Pertussis_Homo sapiens_hsa051330.41102770
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40354191
105Glutathione metabolism_Homo sapiens_hsa004800.40316177
106Hepatitis B_Homo sapiens_hsa051610.40219498
107Alcoholism_Homo sapiens_hsa050340.39946795
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39344388
109Peroxisome_Homo sapiens_hsa041460.38352664
110Ether lipid metabolism_Homo sapiens_hsa005650.37686266
111Lysine degradation_Homo sapiens_hsa003100.37101771
112Shigellosis_Homo sapiens_hsa051310.36851994
113Apoptosis_Homo sapiens_hsa042100.36012144
114* Metabolic pathways_Homo sapiens_hsa011000.34994531
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.34194388
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31844589
117HTLV-I infection_Homo sapiens_hsa051660.31544496
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.31337754
119Melanoma_Homo sapiens_hsa052180.31204940
120Alzheimers disease_Homo sapiens_hsa050100.30158923
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30125224
122MicroRNAs in cancer_Homo sapiens_hsa052060.30008178
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29637172
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26977619
125Prostate cancer_Homo sapiens_hsa052150.26837884
126Nitrogen metabolism_Homo sapiens_hsa009100.25468182
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25397166
128Linoleic acid metabolism_Homo sapiens_hsa005910.24589553
129Small cell lung cancer_Homo sapiens_hsa052220.22819159
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22120051
131Arginine and proline metabolism_Homo sapiens_hsa003300.22046127
132Phototransduction_Homo sapiens_hsa047440.21755017
133Osteoclast differentiation_Homo sapiens_hsa043800.21418934
134Tuberculosis_Homo sapiens_hsa051520.20656722
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19863362
136Adherens junction_Homo sapiens_hsa045200.19836637
137beta-Alanine metabolism_Homo sapiens_hsa004100.18645155
138Renin-angiotensin system_Homo sapiens_hsa046140.18160375
139Salmonella infection_Homo sapiens_hsa051320.18143413
140Vitamin digestion and absorption_Homo sapiens_hsa049770.17849879
141Tryptophan metabolism_Homo sapiens_hsa003800.17838947
142Fatty acid elongation_Homo sapiens_hsa000620.15591251
143Gap junction_Homo sapiens_hsa045400.14651307
144Arginine biosynthesis_Homo sapiens_hsa002200.14605793
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.14353173
146Chemical carcinogenesis_Homo sapiens_hsa052040.14097137
147Retinol metabolism_Homo sapiens_hsa008300.13666626
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13554781
149Tight junction_Homo sapiens_hsa045300.11536602
150Caffeine metabolism_Homo sapiens_hsa002320.11090049

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