PRICKLE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.96808080
2ATP synthesis coupled proton transport (GO:0015986)6.99859775
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.99859775
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.98681212
5chaperone-mediated protein transport (GO:0072321)5.84955429
6viral transcription (GO:0019083)5.79645469
7respiratory electron transport chain (GO:0022904)5.72475754
8electron transport chain (GO:0022900)5.65194238
9translational termination (GO:0006415)5.65082852
10ribosomal small subunit biogenesis (GO:0042274)5.58328318
11ribosomal large subunit biogenesis (GO:0042273)5.54249682
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.47564179
13cotranslational protein targeting to membrane (GO:0006613)5.41771993
14proteasome assembly (GO:0043248)5.41380523
15protein targeting to ER (GO:0045047)5.38728921
16protein complex biogenesis (GO:0070271)5.33616754
17transcription elongation from RNA polymerase III promoter (GO:0006385)5.21506780
18termination of RNA polymerase III transcription (GO:0006386)5.21506780
19mitochondrial respiratory chain complex assembly (GO:0033108)5.20518842
20rRNA modification (GO:0000154)5.18995780
21establishment of protein localization to endoplasmic reticulum (GO:0072599)5.16681165
22protein localization to endoplasmic reticulum (GO:0070972)5.12420763
23establishment of protein localization to mitochondrial membrane (GO:0090151)5.11889166
24locomotory exploration behavior (GO:0035641)5.00277908
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.88334476
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.88334476
27NADH dehydrogenase complex assembly (GO:0010257)4.88334476
28translational elongation (GO:0006414)4.85389290
29rRNA methylation (GO:0031167)4.83344475
30regulation of mitochondrial translation (GO:0070129)4.68946411
31maturation of SSU-rRNA (GO:0030490)4.61366295
32translation (GO:0006412)4.58339537
33cellular modified amino acid catabolic process (GO:0042219)4.53058203
34viral life cycle (GO:0019058)4.45035963
35ribosomal small subunit assembly (GO:0000028)4.44123357
36translational initiation (GO:0006413)4.41361263
37coenzyme catabolic process (GO:0009109)4.37752703
38protein neddylation (GO:0045116)4.34522008
39cellular protein complex disassembly (GO:0043624)4.32673377
40C4-dicarboxylate transport (GO:0015740)4.31634621
41glutamate secretion (GO:0014047)4.23383344
42respiratory chain complex IV assembly (GO:0008535)4.20051294
43protein targeting to mitochondrion (GO:0006626)4.14885606
44water-soluble vitamin biosynthetic process (GO:0042364)4.13322072
45alpha-linolenic acid metabolic process (GO:0036109)4.09653926
46dicarboxylic acid biosynthetic process (GO:0043650)4.09343057
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07961212
48cytochrome complex assembly (GO:0017004)4.03075840
49synaptic vesicle maturation (GO:0016188)4.00490722
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.98370907
51cellular component biogenesis (GO:0044085)3.97222587
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96345054
53regulation of oxidative phosphorylation (GO:0002082)3.85386696
54sulfur amino acid catabolic process (GO:0000098)3.82144789
55ribonucleoprotein complex biogenesis (GO:0022613)3.81588062
56L-amino acid import (GO:0043092)3.77532505
57hydrogen ion transmembrane transport (GO:1902600)3.74333523
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73534998
59transcription elongation from RNA polymerase I promoter (GO:0006362)3.72092788
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.71312574
61establishment of protein localization to mitochondrion (GO:0072655)3.71263984
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71031219
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68791708
64L-phenylalanine metabolic process (GO:0006558)3.68791708
65ATP biosynthetic process (GO:0006754)3.68107629
66protein localization to mitochondrion (GO:0070585)3.67145416
67rRNA processing (GO:0006364)3.66894320
68negative regulation of ligase activity (GO:0051352)3.66073185
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66073185
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63461777
71L-phenylalanine catabolic process (GO:0006559)3.63461777
72cullin deneddylation (GO:0010388)3.60440589
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.59731992
74regulation of cellular amino acid metabolic process (GO:0006521)3.59411100
75protein targeting to membrane (GO:0006612)3.58788644
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55451554
77protein complex disassembly (GO:0043241)3.54532725
78CDP-diacylglycerol biosynthetic process (GO:0016024)3.54255130
79CDP-diacylglycerol metabolic process (GO:0046341)3.54192684
80rRNA metabolic process (GO:0016072)3.52664374
81glutamate metabolic process (GO:0006536)3.52630644
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.50545161
83exploration behavior (GO:0035640)3.49927677
84pseudouridine synthesis (GO:0001522)3.47410247
85lysine catabolic process (GO:0006554)3.46206758
86lysine metabolic process (GO:0006553)3.46206758
87macromolecular complex disassembly (GO:0032984)3.43332131
88transcription from RNA polymerase I promoter (GO:0006360)3.43193815
89regulation of short-term neuronal synaptic plasticity (GO:0048172)3.43064012
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42729736
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42729736
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39668255
93termination of RNA polymerase I transcription (GO:0006363)3.39637945
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35162265
95proton transport (GO:0015992)3.33606650
96spliceosomal snRNP assembly (GO:0000387)3.33526001
97protein-cofactor linkage (GO:0018065)3.32422086
98aspartate family amino acid catabolic process (GO:0009068)3.31934054
99mitochondrial transport (GO:0006839)3.31463001
100synaptic vesicle docking involved in exocytosis (GO:0016081)3.30290191
101protein deneddylation (GO:0000338)3.30061570
102regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.29441543
103hydrogen transport (GO:0006818)3.28979304
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28660777
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28660777
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28660777
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28113891
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28113891
1097-methylguanosine mRNA capping (GO:0006370)3.27539776
110synaptic vesicle exocytosis (GO:0016079)3.25999888
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22568291
112nuclear-transcribed mRNA catabolic process (GO:0000956)3.19365131
113regulation of cholesterol homeostasis (GO:2000188)3.19054265
1147-methylguanosine RNA capping (GO:0009452)3.18738186
115RNA capping (GO:0036260)3.18738186
116reverse cholesterol transport (GO:0043691)3.16833311
117negative regulation of potassium ion transmembrane transport (GO:1901380)3.16627457
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15689134
119signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15590690
120signal transduction involved in DNA damage checkpoint (GO:0072422)3.15590690
121positive regulation of triglyceride biosynthetic process (GO:0010867)3.14870600
122negative regulation of protein oligomerization (GO:0032460)3.14239850
123ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13841178
124auditory behavior (GO:0031223)3.12179287
125triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11241133
126signal transduction involved in cell cycle checkpoint (GO:0072395)3.07951238
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07859674
128positive regulation of ligase activity (GO:0051351)3.07776137
129kynurenine metabolic process (GO:0070189)3.07251606
130cell communication by electrical coupling (GO:0010644)3.06691358
131response to auditory stimulus (GO:0010996)3.05481173
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04041451
133mRNA catabolic process (GO:0006402)3.02941197
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01810452
135tRNA processing (GO:0008033)3.00486824
136transcription-coupled nucleotide-excision repair (GO:0006283)3.00307776
137regulation of beta-amyloid formation (GO:1902003)2.99709616
138ethanol oxidation (GO:0006069)2.98368012
139dicarboxylic acid catabolic process (GO:0043649)2.97925745
140sodium ion export (GO:0071436)2.97913028
141mannosylation (GO:0097502)2.97153107
142DNA catabolic process, exonucleolytic (GO:0000738)2.96758384
143intracellular protein transmembrane import (GO:0044743)2.96445298
144gamma-aminobutyric acid transport (GO:0015812)2.95838818
145glial cell proliferation (GO:0014009)2.93512786
146aromatic amino acid family catabolic process (GO:0009074)2.93444802
147fructose metabolic process (GO:0006000)2.92367953
148biotin metabolic process (GO:0006768)2.91004872
149negative regulation of sodium ion transport (GO:0010766)2.90370576
150neuron cell-cell adhesion (GO:0007158)2.89984134
151cofactor catabolic process (GO:0051187)2.89773222
152bile acid biosynthetic process (GO:0006699)2.89339666
153dendritic spine morphogenesis (GO:0060997)2.89239620
154regulation of triglyceride biosynthetic process (GO:0010866)2.87214104
155activation of protein kinase A activity (GO:0034199)2.87184718
156neurotransmitter secretion (GO:0007269)2.86886241
157cellular potassium ion homeostasis (GO:0030007)2.84061865
158cysteine metabolic process (GO:0006534)2.83000329
159amino acid import (GO:0043090)2.82771720
160cellular amino acid catabolic process (GO:0009063)2.81481505
161alpha-amino acid catabolic process (GO:1901606)2.80329635
162regulation of amyloid precursor protein catabolic process (GO:1902991)2.76569481
163membrane repolarization (GO:0086009)2.76030640
164positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75664981
165positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74974106
166vocalization behavior (GO:0071625)2.71992246
167neuromuscular process controlling balance (GO:0050885)2.71805936
168regulation of fatty acid beta-oxidation (GO:0031998)2.71718288
169membrane repolarization during action potential (GO:0086011)2.70706606
170L-serine metabolic process (GO:0006563)2.70644344
171positive regulation of fatty acid beta-oxidation (GO:0032000)2.70081518
172amino-acid betaine metabolic process (GO:0006577)2.67932568
173homocysteine metabolic process (GO:0050667)2.67744036
174negative regulation of protein localization to cell surface (GO:2000009)2.66670551
175valine metabolic process (GO:0006573)2.65337131
176glutamine family amino acid biosynthetic process (GO:0009084)2.65053709
177regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64299602
178positive regulation of potassium ion transmembrane transport (GO:1901381)2.62723460
179proline transport (GO:0015824)2.62560202
180axonal fasciculation (GO:0007413)2.62286338
181regulation of cholesterol biosynthetic process (GO:0045540)2.61916316
182glyoxylate metabolic process (GO:0046487)2.61487391
183positive regulation of triglyceride metabolic process (GO:0090208)2.61187416
184tryptophan catabolic process (GO:0006569)2.60899100
185indole-containing compound catabolic process (GO:0042436)2.60899100
186indolalkylamine catabolic process (GO:0046218)2.60899100
187hormone catabolic process (GO:0042447)2.59856574
188high-density lipoprotein particle remodeling (GO:0034375)2.55201974
189alanine transport (GO:0032328)2.55198419
190negative regulation of sterol transport (GO:0032372)2.54466903
191negative regulation of cholesterol transport (GO:0032375)2.54466903
192L-glutamate transport (GO:0015813)2.54256585
193acidic amino acid transport (GO:0015800)2.52666121
194negative regulation of fibrinolysis (GO:0051918)2.52604141
195positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.52019888
196layer formation in cerebral cortex (GO:0021819)2.51683257
197neuronal action potential propagation (GO:0019227)2.50490763
198serine family amino acid catabolic process (GO:0009071)2.49111986
199serine family amino acid biosynthetic process (GO:0009070)2.48815073
200cerebellar granule cell differentiation (GO:0021707)2.47088596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.57696917
2GABP_17652178_ChIP-ChIP_JURKAT_Human5.30593504
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15741435
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.87129151
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.81527361
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.44306386
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.03126176
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.72233430
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.61972406
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.51874588
11EZH2_22144423_ChIP-Seq_EOC_Human3.48224927
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42510526
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25214348
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.22846880
15PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00005793
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94100283
17VDR_23849224_ChIP-Seq_CD4+_Human2.91507059
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87870637
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85692640
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.85053135
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81004990
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.71192860
23ELK1_19687146_ChIP-ChIP_HELA_Human2.68985281
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68821714
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.67644460
26DCP1A_22483619_ChIP-Seq_HELA_Human2.61555222
27FOXP3_21729870_ChIP-Seq_TREG_Human2.54527577
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.51971522
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50505773
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48964436
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45956201
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44973676
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42314436
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37209830
35TTF2_22483619_ChIP-Seq_HELA_Human2.26990643
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25320050
37* XRN2_22483619_ChIP-Seq_HELA_Human2.25185863
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24960710
39IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22783771
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19969325
41RARB_27405468_Chip-Seq_BRAIN_Mouse2.17965692
42THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16737915
43GABP_19822575_ChIP-Seq_HepG2_Human2.13195015
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12794925
45E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08592298
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05799448
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05001642
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01578913
49LXR_22292898_ChIP-Seq_THP-1_Human2.00815083
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99369512
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98703448
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98010556
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97280724
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92527235
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92503275
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90506356
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90506356
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83146247
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81705010
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81473054
61REST_21632747_ChIP-Seq_MESCs_Mouse1.81333855
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80464574
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79462202
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78109734
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76598848
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.76504596
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75414787
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74086012
69KDM2B_26808549_Chip-Seq_K562_Human1.72643148
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70314420
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.68128180
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65887891
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65540286
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63242174
75DROSHA_22980978_ChIP-Seq_HELA_Human1.62951296
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62906874
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.62093337
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60275715
79MYC_18940864_ChIP-ChIP_HL60_Human1.59845264
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58195204
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58063766
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53439547
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51953093
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48812045
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46892654
86AR_21572438_ChIP-Seq_LNCaP_Human1.45261209
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44653236
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.42699455
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42147425
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.40988225
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40491351
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.39296593
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39237525
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39015749
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38917956
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38758820
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37629208
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36002399
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33370549
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33135658
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29919125
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29434125
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28901714
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28543011
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28120931
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27739327
107KDM5A_27292631_Chip-Seq_BREAST_Human1.27632832
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27549209
109CREB1_26743006_Chip-Seq_LNCaP_Human1.27422713
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.26099567
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25262327
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22717849
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18595146
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18217985
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17516431
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15514746
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.14873765
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14605745
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12824616
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.12791852
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12487110
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10940020
123RING1B_27294783_Chip-Seq_NPCs_Mouse1.10219157
124KDM2B_26808549_Chip-Seq_DND41_Human1.09587523
125FOXA2_19822575_ChIP-Seq_HepG2_Human1.08135297
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07373892
127SMC4_20622854_ChIP-Seq_HELA_Human1.06384036
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06189471
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05504769
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.05364748
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04880626
132CLOCK_20551151_ChIP-Seq_293T_Human1.04475966
133ELF5_23300383_ChIP-Seq_T47D_Human1.03028484
134CTCF_27219007_Chip-Seq_Bcells_Human1.02970694
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01463940
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.01188016
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99941813
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99470355
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99238478
140RACK7_27058665_Chip-Seq_MCF-7_Human0.98195019
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96395543
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96275723
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95782908
144CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95399885
145EOMES_21245162_ChIP-Seq_HESCs_Human0.94684156
146FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94439237
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94192341
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94031656
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92179172
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91911698
151TRIM28_21343339_ChIP-Seq_HEK293_Human0.91587358
152SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91586286
153GBX2_23144817_ChIP-Seq_PC3_Human0.91492260
154KLF4_19829295_ChIP-Seq_ESCs_Human0.91378247
155VDR_22108803_ChIP-Seq_LS180_Human0.90711629
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89400969
157AR_19668381_ChIP-Seq_PC3_Human0.88322821
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.87194732
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87094528
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86979294
161TP63_22573176_ChIP-Seq_HFKS_Human0.86493816
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86223036
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84548658
164KDM2B_26808549_Chip-Seq_JURKAT_Human0.84019020
165NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83843934
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83660596
167POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83600362
168ZNF263_19887448_ChIP-Seq_K562_Human0.83527548
169* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83193738
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83162084
171P68_20966046_ChIP-Seq_HELA_Human0.82643791
172HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82053349
173SA1_27219007_Chip-Seq_Bcells_Human0.81772123
174TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81749681
175MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81411657
176SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.80553744
177DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78528668
178EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77782251
179E2F1_21310950_ChIP-Seq_MCF-7_Human0.77692398
180* TP53_22573176_ChIP-Seq_HFKS_Human0.77525363
181AR_20517297_ChIP-Seq_VCAP_Human0.74044474
182TFEB_21752829_ChIP-Seq_HELA_Human0.73112232
183EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72795556
184CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72575736
185ERG_20517297_ChIP-Seq_VCAP_Human0.72435920
186GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72186863
187SOX17_20123909_ChIP-Seq_XEN_Mouse0.70579412
188IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69414803
189HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68454136
190STAT1_20625510_ChIP-Seq_HELA_Human0.68104511
191FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67626628
192FOXA1_25329375_ChIP-Seq_VCAP_Human0.67626628
193EWS_26573619_Chip-Seq_HEK293_Human0.66322431
194NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66070475
195TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65621159
196NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65257124
197CIITA_25753668_ChIP-Seq_RAJI_Human0.64277544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.71594618
2MP0004859_abnormal_synaptic_plasticity4.29808346
3MP0004858_abnormal_nervous_system3.87369761
4MP0009379_abnormal_foot_pigmentation3.52555417
5MP0005360_urolithiasis3.45991631
6MP0005365_abnormal_bile_salt3.42124359
7MP0003329_amyloid_beta_deposits3.35816711
8MP0003186_abnormal_redox_activity2.90656791
9MP0005085_abnormal_gallbladder_physiolo2.87091450
10MP0003011_delayed_dark_adaptation2.70999874
11MP0003786_premature_aging2.69722166
12MP0008058_abnormal_DNA_repair2.65109487
13MP0003635_abnormal_synaptic_transmissio2.50595613
14MP0003718_maternal_effect2.48953414
15MP0004270_analgesia2.43616935
16MP0002837_dystrophic_cardiac_calcinosis2.39973687
17MP0010329_abnormal_lipoprotein_level2.38040149
18MP0006072_abnormal_retinal_apoptosis2.33836018
19MP0003806_abnormal_nucleotide_metabolis2.28424520
20MP0008875_abnormal_xenobiotic_pharmacok2.20987040
21MP0002938_white_spotting2.13996363
22MP0009697_abnormal_copulation2.13872663
23MP0004957_abnormal_blastocyst_morpholog2.11591740
24MP0003705_abnormal_hypodermis_morpholog2.04805039
25MP0003693_abnormal_embryo_hatching2.02780216
26MP0005083_abnormal_biliary_tract1.98970821
27MP0002064_seizures1.97962612
28MP0009745_abnormal_behavioral_response1.97928246
29MP0000516_abnormal_urinary_system1.96956599
30MP0005367_renal/urinary_system_phenotyp1.96956599
31MP0000604_amyloidosis1.88595770
32MP0008007_abnormal_cellular_replicative1.86334503
33MP0010094_abnormal_chromosome_stability1.86158061
34MP0001905_abnormal_dopamine_level1.85135140
35MP0002063_abnormal_learning/memory/cond1.83528006
36MP0002909_abnormal_adrenal_gland1.82459540
37MP0005084_abnormal_gallbladder_morpholo1.75469685
38MP0001984_abnormal_olfaction1.74946658
39MP0001764_abnormal_homeostasis1.71569313
40MP0006292_abnormal_olfactory_placode1.70559221
41MP0001486_abnormal_startle_reflex1.69245327
42MP0009046_muscle_twitch1.67887300
43MP0003690_abnormal_glial_cell1.64018610
44MP0001666_abnormal_nutrient_absorption1.62967925
45MP0010030_abnormal_orbit_morphology1.62600965
46MP0002572_abnormal_emotion/affect_behav1.62480454
47MP0001756_abnormal_urination1.61600649
48MP0002822_catalepsy1.59594406
49MP0003252_abnormal_bile_duct1.57938962
50MP0005332_abnormal_amino_acid1.51328483
51MP0003632_abnormal_nervous_system1.49731542
52MP0002118_abnormal_lipid_homeostasis1.48960242
53MP0002272_abnormal_nervous_system1.48858366
54MP0009780_abnormal_chondrocyte_physiolo1.48431077
55MP0003077_abnormal_cell_cycle1.47526375
56MP0003111_abnormal_nucleus_morphology1.45701368
57MP0004130_abnormal_muscle_cell1.45518789
58MP0002277_abnormal_respiratory_mucosa1.43104602
59MP0002160_abnormal_reproductive_system1.42301738
60MP0010386_abnormal_urinary_bladder1.40993844
61MP0002733_abnormal_thermal_nociception1.37580226
62MP0009333_abnormal_splenocyte_physiolog1.36941868
63MP0009840_abnormal_foam_cell1.36804381
64MP0003075_altered_response_to1.34349478
65MP0005058_abnormal_lysosome_morphology1.33086105
66MP0002734_abnormal_mechanical_nocicepti1.32543544
67MP0005636_abnormal_mineral_homeostasis1.31561414
68MP0003880_abnormal_central_pattern1.30642634
69MP0003137_abnormal_impulse_conducting1.29958899
70MP0002876_abnormal_thyroid_physiology1.29922260
71MP0001853_heart_inflammation1.28067074
72MP0005584_abnormal_enzyme/coenzyme_acti1.24813090
73MP0004885_abnormal_endolymph1.22565413
74MP0002102_abnormal_ear_morphology1.20831449
75MP0003191_abnormal_cellular_cholesterol1.20414548
76MP0003631_nervous_system_phenotype1.19457354
77MP0002638_abnormal_pupillary_reflex1.16925496
78MP0004019_abnormal_vitamin_homeostasis1.16391528
79MP0008877_abnormal_DNA_methylation1.14928156
80MP0003172_abnormal_lysosome_physiology1.14887080
81MP0003633_abnormal_nervous_system1.14479212
82MP0003283_abnormal_digestive_organ1.13839104
83MP0002736_abnormal_nociception_after1.12767604
84MP0005408_hypopigmentation1.11648895
85MP0002210_abnormal_sex_determination1.10311110
86MP0005410_abnormal_fertilization1.09033463
87MP0008961_abnormal_basal_metabolism1.07968127
88MP0008872_abnormal_physiological_respon1.07631795
89MP0005535_abnormal_body_temperature1.07468721
90MP0005646_abnormal_pituitary_gland1.06886698
91MP0008569_lethality_at_weaning1.06666270
92MP0009643_abnormal_urine_homeostasis1.05744337
93MP0010368_abnormal_lymphatic_system1.05629189
94MP0000955_abnormal_spinal_cord1.05307221
95MP0000751_myopathy1.05261556
96MP0000358_abnormal_cell_content/1.04893265
97MP0005319_abnormal_enzyme/_coenzyme1.04717227
98MP0000747_muscle_weakness1.03802770
99MP0008873_increased_physiological_sensi1.02979418
100MP0000013_abnormal_adipose_tissue1.02641472
101MP0000609_abnormal_liver_physiology1.02440554
102MP0002067_abnormal_sensory_capabilities1.02352575
103MP0003638_abnormal_response/metabolism_1.01579119
104MP0005645_abnormal_hypothalamus_physiol1.01150143
105MP0001835_abnormal_antigen_presentation1.00900305
106MP0001968_abnormal_touch/_nociception1.00092946
107MP0006035_abnormal_mitochondrial_morpho0.98670915
108MP0001970_abnormal_pain_threshold0.98425127
109MP0003315_abnormal_perineum_morphology0.97754939
110MP0001440_abnormal_grooming_behavior0.97340773
111MP0004145_abnormal_muscle_electrophysio0.96855548
112MP0002090_abnormal_vision0.96693464
113MP0004147_increased_porphyrin_level0.95900205
114MP0002132_abnormal_respiratory_system0.95234239
115MP0008995_early_reproductive_senescence0.94184336
116MP0005386_behavior/neurological_phenoty0.93950459
117MP0004924_abnormal_behavior0.93950459
118MP0005389_reproductive_system_phenotype0.93696426
119MP0003868_abnormal_feces_composition0.92403130
120MP0000372_irregular_coat_pigmentation0.91223093
121MP0002066_abnormal_motor_capabilities/c0.90422081
122MP0001944_abnormal_pancreas_morphology0.90363623
123MP0003195_calcinosis0.87668641
124MP0008874_decreased_physiological_sensi0.87355496
125MP0005423_abnormal_somatic_nervous0.87345405
126MP0002078_abnormal_glucose_homeostasis0.87230709
127MP0006036_abnormal_mitochondrial_physio0.87212140
128MP0004215_abnormal_myocardial_fiber0.85790692
129MP0002148_abnormal_hypersensitivity_rea0.84855391
130MP0002882_abnormal_neuron_morphology0.82203588
131MP0003634_abnormal_glial_cell0.82049154
132MP0004811_abnormal_neuron_physiology0.81944438
133MP0004142_abnormal_muscle_tone0.81669834
134MP0002557_abnormal_social/conspecific_i0.80463363
135MP0000778_abnormal_nervous_system0.79983583
136MP0004043_abnormal_pH_regulation0.79093683
137MP0001145_abnormal_male_reproductive0.79013710
138MP0003183_abnormal_peptide_metabolism0.78640568
139MP0005330_cardiomyopathy0.78190645
140MP0005448_abnormal_energy_balance0.78108669
141MP0002089_abnormal_postnatal_growth/wei0.77955183
142MP0005551_abnormal_eye_electrophysiolog0.77713891
143MP0009672_abnormal_birth_weight0.77350868
144MP0002971_abnormal_brown_adipose0.77059379
145MP0001765_abnormal_ion_homeostasis0.76432912
146MP0000653_abnormal_sex_gland0.75952814
147MP0002269_muscular_atrophy0.75478281
148MP0002653_abnormal_ependyma_morphology0.75382945
149MP0002184_abnormal_innervation0.75289953
150MP0001929_abnormal_gametogenesis0.74972362
151MP0001501_abnormal_sleep_pattern0.72733660
152MP0002069_abnormal_eating/drinking_beha0.72286948
153MP0002970_abnormal_white_adipose0.71942054
154MP0002332_abnormal_exercise_endurance0.71779061
155MP0001986_abnormal_taste_sensitivity0.71278240
156MP0005452_abnormal_adipose_tissue0.71254282
157MP0000538_abnormal_urinary_bladder0.71186505
158MP0004087_abnormal_muscle_fiber0.70849081
159MP0002229_neurodegeneration0.70490776
160MP0008775_abnormal_heart_ventricle0.70424244
161MP0002693_abnormal_pancreas_physiology0.69494455
162MP0001664_abnormal_digestion0.69367825
163MP0005501_abnormal_skin_physiology0.69086543
164MP0003879_abnormal_hair_cell0.68918185
165MP0001873_stomach_inflammation0.68511460
166MP0005379_endocrine/exocrine_gland_phen0.68386234
167MP0001542_abnormal_bone_strength0.68014517
168MP0000313_abnormal_cell_death0.67504531
169MP0002295_abnormal_pulmonary_circulatio0.66842425
170MP0005165_increased_susceptibility_to0.66784783
171MP0001881_abnormal_mammary_gland0.66399344
172MP0001529_abnormal_vocalization0.65627893
173MP0001879_abnormal_lymphatic_vessel0.65374884
174MP0005670_abnormal_white_adipose0.64945777
175MP0005253_abnormal_eye_physiology0.62747395
176MP0005075_abnormal_melanosome_morpholog0.62741909
177MP0002163_abnormal_gland_morphology0.62526320

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.80648865
2Mitochondrial inheritance (HP:0001427)5.52714268
3Increased hepatocellular lipid droplets (HP:0006565)5.24225034
4Hepatocellular necrosis (HP:0001404)5.20019419
5Abnormal mitochondria in muscle tissue (HP:0008316)5.18313886
6Increased CSF lactate (HP:0002490)5.00517367
7Hepatic necrosis (HP:0002605)4.94879283
83-Methylglutaconic aciduria (HP:0003535)4.92874880
9Progressive macrocephaly (HP:0004481)4.85385553
10Acute encephalopathy (HP:0006846)4.80764338
11Renal Fanconi syndrome (HP:0001994)4.76409083
12Lipid accumulation in hepatocytes (HP:0006561)4.70185614
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.58756975
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.58756975
15Congenital, generalized hypertrichosis (HP:0004540)4.42399263
16Deep venous thrombosis (HP:0002625)4.15287313
17Abnormality of the lower motor neuron (HP:0002366)3.99875532
18Exertional dyspnea (HP:0002875)3.98258919
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.92366218
20Abnormal number of erythroid precursors (HP:0012131)3.83535346
21Macrocytic anemia (HP:0001972)3.83258971
22Methylmalonic acidemia (HP:0002912)3.81550217
23Abnormality of cells of the erythroid lineage (HP:0012130)3.73645090
24Myokymia (HP:0002411)3.66611495
25Xanthomatosis (HP:0000991)3.63682134
26Hyperglycinuria (HP:0003108)3.60756369
27Cerebral edema (HP:0002181)3.59853508
28Increased intramyocellular lipid droplets (HP:0012240)3.52429551
29Increased serum lactate (HP:0002151)3.46329130
30Type I transferrin isoform profile (HP:0003642)3.41111983
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33506216
32Postural instability (HP:0002172)3.30897633
33Hyperventilation (HP:0002883)3.30238919
34Ketoacidosis (HP:0001993)3.29765906
35Lactic acidosis (HP:0003128)3.29643626
36Intrahepatic cholestasis (HP:0001406)3.27272222
37Cerebral inclusion bodies (HP:0100314)3.17964040
38Hyperlipoproteinemia (HP:0010980)3.17805795
39Abnormality of methionine metabolism (HP:0010901)3.17031555
40Hemiplegia (HP:0002301)3.16565805
41Abnormality of serine family amino acid metabolism (HP:0010894)3.16412366
42Abnormality of glycine metabolism (HP:0010895)3.16412366
43Respiratory failure (HP:0002878)3.15570326
44Methylmalonic aciduria (HP:0012120)3.14555581
45Neurofibrillary tangles (HP:0002185)3.13270843
46Ketosis (HP:0001946)3.12890416
47Abnormality of renal resorption (HP:0011038)3.12673823
48Supranuclear gaze palsy (HP:0000605)3.10384532
49Visual hallucinations (HP:0002367)3.09928384
50Increased muscle lipid content (HP:0009058)3.09758766
51Exercise intolerance (HP:0003546)3.04834958
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99485951
53Dysdiadochokinesis (HP:0002075)2.98112441
54Generalized aminoaciduria (HP:0002909)2.90191693
55Respiratory difficulties (HP:0002880)2.89771451
56Glycosuria (HP:0003076)2.84282152
57Abnormality of urine glucose concentration (HP:0011016)2.84282152
58Hyperammonemia (HP:0001987)2.80136358
59Testicular atrophy (HP:0000029)2.79724838
60Focal motor seizures (HP:0011153)2.77330494
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75264471
62Abnormal protein N-linked glycosylation (HP:0012347)2.75264471
63Abnormal protein glycosylation (HP:0012346)2.75264471
64Abnormal glycosylation (HP:0012345)2.75264471
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73033741
66Abnormality of alanine metabolism (HP:0010916)2.73033741
67Hyperalaninemia (HP:0003348)2.73033741
68Gout (HP:0001997)2.72594401
69Hemiparesis (HP:0001269)2.70566732
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69279442
71Intention tremor (HP:0002080)2.68931384
72Aplasia involving bones of the upper limbs (HP:0009823)2.67639754
73Aplasia of the phalanges of the hand (HP:0009802)2.67639754
74Aplasia involving bones of the extremities (HP:0009825)2.67639754
75Lethargy (HP:0001254)2.66651741
76Aplastic anemia (HP:0001915)2.63278424
77Delayed CNS myelination (HP:0002188)2.62128232
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59078586
79Optic disc pallor (HP:0000543)2.57842451
80Hypobetalipoproteinemia (HP:0003563)2.57346096
81Global brain atrophy (HP:0002283)2.56600025
82Leukodystrophy (HP:0002415)2.56532898
83Abnormality of the Achilles tendon (HP:0005109)2.56346841
84Cholecystitis (HP:0001082)2.54393067
85Abnormal gallbladder physiology (HP:0012438)2.54393067
86Status epilepticus (HP:0002133)2.50585705
87Focal seizures (HP:0007359)2.50539427
88Reduced antithrombin III activity (HP:0001976)2.49621328
89Myoglobinuria (HP:0002913)2.48207462
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47050963
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46991985
92Dicarboxylic aciduria (HP:0003215)2.46991985
93Skin nodule (HP:0200036)2.45448622
94Action tremor (HP:0002345)2.45446503
95Generalized tonic-clonic seizures (HP:0002069)2.44579780
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43796059
97Pseudobulbar signs (HP:0002200)2.41935553
98Pheochromocytoma (HP:0002666)2.40497711
99Tetraplegia (HP:0002445)2.40182476
100Abnormality of homocysteine metabolism (HP:0010919)2.37145462
101Homocystinuria (HP:0002156)2.37145462
102Pallor (HP:0000980)2.36814249
103Resting tremor (HP:0002322)2.36721877
104Prolonged partial thromboplastin time (HP:0003645)2.33939682
105Horizontal nystagmus (HP:0000666)2.33796972
106Megaloblastic anemia (HP:0001889)2.32883765
107Abnormality of vitamin B metabolism (HP:0004340)2.32233892
108Impaired smooth pursuit (HP:0007772)2.30783833
109Dysmetric saccades (HP:0000641)2.29288176
110Achilles tendon contracture (HP:0001771)2.27172086
111Hyperglycinemia (HP:0002154)2.26780671
112Abnormality of ocular smooth pursuit (HP:0000617)2.26709782
113Reticulocytopenia (HP:0001896)2.26013368
114Hypothermia (HP:0002045)2.24998620
115Abnormality of placental membranes (HP:0011409)2.24220063
116Amniotic constriction ring (HP:0009775)2.24220063
117Truncal ataxia (HP:0002078)2.24118302
118Back pain (HP:0003418)2.24113922
119Epileptic encephalopathy (HP:0200134)2.23751244
120Exercise-induced myalgia (HP:0003738)2.22416024
121CNS demyelination (HP:0007305)2.22041549
122Complement deficiency (HP:0004431)2.22029410
123Depression (HP:0000716)2.20641984
124Ragged-red muscle fibers (HP:0003200)2.19682436
125Bilateral microphthalmos (HP:0007633)2.19633644
126Oral leukoplakia (HP:0002745)2.19333161
127Hyperphosphaturia (HP:0003109)2.18110833
128Abnormality of serum amino acid levels (HP:0003112)2.17898689
129Abnormality of the vitamin B12 metabolism (HP:0004341)2.14245909
130Bradykinesia (HP:0002067)2.13402687
131Abnormality of the anterior horn cell (HP:0006802)2.12954941
132Degeneration of anterior horn cells (HP:0002398)2.12954941
133Neuroendocrine neoplasm (HP:0100634)2.12921398
134Turricephaly (HP:0000262)2.12812410
135Increased serum pyruvate (HP:0003542)2.11793827
136Hepatoblastoma (HP:0002884)2.11228314
137Renal tubular dysfunction (HP:0000124)2.10879872
138Neonatal onset (HP:0003623)2.10586347
139Sensorimotor neuropathy (HP:0007141)2.09867731
140Hypochromic microcytic anemia (HP:0004840)2.08448933
141Epidermoid cyst (HP:0200040)2.07784085
142Abnormal eating behavior (HP:0100738)2.06861948
143Abnormality of the intrinsic pathway (HP:0010989)2.06849518
144Abnormality of fatty-acid metabolism (HP:0004359)2.06774318
145Hypoglycemic seizures (HP:0002173)2.06613189
146Impaired social interactions (HP:0000735)2.05793898
147Abnormal social behavior (HP:0012433)2.05793898
148Generalized hypotonia (HP:0001290)2.04419615
149Cholelithiasis (HP:0001081)2.00776073
150Dysmetria (HP:0001310)1.99007025
151Abnormal urine phosphate concentration (HP:0012599)1.98414219
152Upper limb amyotrophy (HP:0009129)1.97778537
153Distal upper limb amyotrophy (HP:0007149)1.97778537
154Large for gestational age (HP:0001520)1.97538363
155Hypolipoproteinemia (HP:0010981)1.96531244
156EMG: neuropathic changes (HP:0003445)1.95356657
157Spastic diplegia (HP:0001264)1.93516586
158X-linked dominant inheritance (HP:0001423)1.93491710
159Generalized myoclonic seizures (HP:0002123)1.92734839
160Metabolic acidosis (HP:0001942)1.91895857
161Opisthotonus (HP:0002179)1.90704603
162Abnormal gallbladder morphology (HP:0012437)1.90568060
163Emotional lability (HP:0000712)1.85837889
164Hypoalphalipoproteinemia (HP:0003233)1.85491509
165Sparse eyelashes (HP:0000653)1.85347168
166Cleft eyelid (HP:0000625)1.84946047
167Hyperinsulinemic hypoglycemia (HP:0000825)1.84524766
168Rigidity (HP:0002063)1.84388273
169Rapidly progressive (HP:0003678)1.84296834
170Woolly hair (HP:0002224)1.83685311
171Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83053791
172Clumsiness (HP:0002312)1.83013429
173Progressive cerebellar ataxia (HP:0002073)1.82970746
174Neuronal loss in central nervous system (HP:0002529)1.82687266
175Hypopigmentation of the fundus (HP:0007894)1.82122663
176Renal cortical cysts (HP:0000803)1.81193762
177Abnormality of the periventricular white matter (HP:0002518)1.81107071
178Aplasia/hypoplasia of the uterus (HP:0008684)1.80814621
179Hypoglycemic coma (HP:0001325)1.80753818
180Spastic tetraparesis (HP:0001285)1.79028788
181Abnormality of midbrain morphology (HP:0002418)1.78211052
182Molar tooth sign on MRI (HP:0002419)1.78211052
183Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77947782
184Morphological abnormality of the pyramidal tract (HP:0002062)1.77649974
185Papilledema (HP:0001085)1.77474091
186Abnormality of sulfur amino acid metabolism (HP:0004339)1.77458555
187Amyloidosis (HP:0011034)1.76491630
188Blindness (HP:0000618)1.76444320
189Neoplasm of the heart (HP:0100544)1.76229772
190Cerebral hypomyelination (HP:0006808)1.74971356
191Palpitations (HP:0001962)1.74932973
192Reticulocytosis (HP:0001923)1.73826484
193Pancreatic cysts (HP:0001737)1.72201656
194Abnormality of glycolysis (HP:0004366)1.71975330
195Congenital ichthyosiform erythroderma (HP:0007431)1.71772130
196Vomiting (HP:0002013)1.71506988
197Abnormal spermatogenesis (HP:0008669)1.67737277
198Hypoplasia of the pons (HP:0012110)1.64330077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.64319360
2TLK14.39565872
3TRIB34.33775112
4STK164.22600898
5MST44.09875061
6BUB13.31187213
7NME12.94265110
8MAP3K42.86117875
9MAP3K122.81207558
10SRPK12.75443053
11SIK12.72724394
12EIF2AK12.63447362
13NTRK12.63094133
14EPHA42.59197057
15MAP2K42.54797388
16NME22.52224608
17MAP3K92.37821368
18GRK62.27359103
19ERN12.23051093
20PKN22.16241962
21GRK52.06887874
22PDK22.05147797
23NTRK22.00883772
24VRK11.98122546
25PHKG11.96925185
26PHKG21.96925185
27PRKD31.87395116
28CDK121.81872673
29MAP2K61.81318685
30NTRK31.79761188
31EPHA21.77440872
32MAP2K71.77000797
33MYLK1.73459226
34LMTK21.72853118
35TYRO31.72583305
36MAP3K71.66258320
37TESK11.64824724
38RIPK11.61285803
39KSR21.56675072
40NUAK11.56470438
41ZAK1.53869810
42TIE11.48583665
43MAP4K21.47347077
44EIF2AK31.46315037
45PAK61.45231541
46CAMKK11.42680681
47ICK1.40292946
48BCKDK1.40027545
49MAP3K101.37216592
50DMPK1.36410016
51PAK41.34530966
52DAPK21.29028058
53WNK41.26888675
54BMPR1B1.24238753
55MINK11.22844879
56INSRR1.22491860
57LIMK11.21948024
58ADRBK21.21531279
59PLK41.20390284
60RET1.18298314
61GRK11.17844701
62PDGFRA1.17684031
63PDK31.13417763
64PDK41.13417763
65TSSK61.13255767
66CDK81.09752503
67ILK1.09195209
68OXSR11.08835770
69PLK31.06983926
70WNK11.05307037
71TESK21.01348572
72KSR11.00492199
73STK381.00222855
74MAPK150.99047560
75SIK20.97888229
76DDR20.96876563
77ABL20.95759873
78PTK60.95158898
79CASK0.94685438
80NEK10.94577545
81MAP3K130.94155735
82TAOK10.93217701
83LATS20.93045940
84PAK30.91389707
85CCNB10.91192167
86CAMK1G0.90956462
87MARK10.87532919
88MARK20.86618843
89PLK10.84636051
90WNK30.83606822
91CDC42BPA0.83494682
92PRKCG0.83068739
93BMX0.82961404
94FLT30.82689877
95PIM20.82380128
96AURKB0.82200891
97CDK50.81684758
98PRKCH0.81166251
99ALK0.81005163
100MAPK70.80828450
101MAPKAPK30.80618382
102IKBKB0.80272289
103MST1R0.79538683
104PBK0.79421889
105CAMK1D0.74943684
106CAMK40.74637805
107CDC70.74604137
108PRKCI0.74261264
109ARAF0.73997590
110STK110.72001333
111MATK0.71958858
112RPS6KB20.71349025
113MAPK120.69024657
114CSNK1G30.68224616
115TAF10.67707258
116FRK0.67487952
117CSNK2A20.67052901
118BRSK10.66888997
119KDR0.65734186
120UHMK10.65494524
121CDK190.64519543
122EIF2AK20.64181111
123PDK10.62916750
124SGK30.62503783
125MAPKAPK50.61905493
126MAP3K60.61291674
127CSNK2A10.60877294
128CSNK1G10.60851290
129PASK0.60174146
130SGK4940.59705165
131SGK2230.59705165
132RAF10.59242156
133MAPK130.58904460
134DAPK10.58429618
135STK390.57478572
136MUSK0.57458023
137RPS6KA20.56477112
138FGR0.55692624
139EEF2K0.54691519
140DAPK30.54493971
141BMPR20.54102739
142CAMKK20.53043119
143CDK150.51774100
144CSF1R0.51686326
145CAMK2B0.50437402
146CAMK2G0.48540406
147CDK180.47549572
148PRKAA10.46322187
149PRKD20.46163024
150PDPK10.46047388
151MAPK40.45435799
152LRRK20.43993100
153CDK70.43610830
154RPS6KA30.43599122
155SGK20.43588647
156PTK20.43507527
157RPS6KA50.43316416
158PTK2B0.43269696
159CDK11A0.42430722
160CDK140.42382836
161TAOK30.40364637
162CSNK1G20.39318909
163PNCK0.38760295
164PRKACG0.38689052
165SGK10.38429917
166TRIM280.37855109
167ATR0.37773511
168CAMK2D0.37044312
169TTK0.36860942
170TNK20.35544840
171ADRBK10.34741274
172MET0.33975081
173TEC0.33567927
174CSNK1A1L0.33181689
175CDK30.31837022
176CLK10.31633059
177AURKA0.30688189
178MAP2K30.30345589
179CSNK1A10.30305006
180DYRK20.27196656
181CSNK1E0.26031208
182SCYL20.25685009
183STK38L0.25052922
184PRKG10.23513023
185FGFR10.21544812
186TXK0.21121851
187NEK20.20801649

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.12849350
2Oxidative phosphorylation_Homo sapiens_hsa001904.66327214
3Proteasome_Homo sapiens_hsa030504.13052980
4Parkinsons disease_Homo sapiens_hsa050123.71903026
5Nitrogen metabolism_Homo sapiens_hsa009103.59881853
6Protein export_Homo sapiens_hsa030603.42691677
7RNA polymerase_Homo sapiens_hsa030203.04315731
8Huntingtons disease_Homo sapiens_hsa050162.61816580
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56081973
10Alzheimers disease_Homo sapiens_hsa050102.48850358
11Homologous recombination_Homo sapiens_hsa034402.48192755
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43534344
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42405007
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.36638900
15Vitamin B6 metabolism_Homo sapiens_hsa007502.32893506
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31456035
17Mismatch repair_Homo sapiens_hsa034302.29424277
18Fatty acid degradation_Homo sapiens_hsa000712.17055827
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12824332
20Fatty acid metabolism_Homo sapiens_hsa012122.09378066
21Arginine biosynthesis_Homo sapiens_hsa002202.08837314
22Nucleotide excision repair_Homo sapiens_hsa034202.08654235
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06776054
24DNA replication_Homo sapiens_hsa030302.05868704
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97225519
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94658318
27Propanoate metabolism_Homo sapiens_hsa006401.78476382
28Basal transcription factors_Homo sapiens_hsa030221.72380953
29Bile secretion_Homo sapiens_hsa049761.71471769
30Spliceosome_Homo sapiens_hsa030401.68785431
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66981494
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65445220
33Tryptophan metabolism_Homo sapiens_hsa003801.64372524
34Pyrimidine metabolism_Homo sapiens_hsa002401.62420604
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60289868
36PPAR signaling pathway_Homo sapiens_hsa033201.58216520
37Cardiac muscle contraction_Homo sapiens_hsa042601.56205365
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54959990
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54881213
40One carbon pool by folate_Homo sapiens_hsa006701.54715147
41Fatty acid biosynthesis_Homo sapiens_hsa000611.54079886
42RNA degradation_Homo sapiens_hsa030181.52681454
43Sulfur relay system_Homo sapiens_hsa041221.51209921
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51114701
45Synaptic vesicle cycle_Homo sapiens_hsa047211.49948641
46Glutamatergic synapse_Homo sapiens_hsa047241.47194650
47Base excision repair_Homo sapiens_hsa034101.45288853
48Butanoate metabolism_Homo sapiens_hsa006501.45067158
49Biosynthesis of amino acids_Homo sapiens_hsa012301.44255821
50Carbon metabolism_Homo sapiens_hsa012001.43394422
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40665681
52Collecting duct acid secretion_Homo sapiens_hsa049661.40514239
53Glycerolipid metabolism_Homo sapiens_hsa005611.39400569
54Complement and coagulation cascades_Homo sapiens_hsa046101.33279321
55GABAergic synapse_Homo sapiens_hsa047271.31979231
56Fructose and mannose metabolism_Homo sapiens_hsa000511.30535465
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29841129
58Pyruvate metabolism_Homo sapiens_hsa006201.27822365
59Asthma_Homo sapiens_hsa053101.23786579
60Olfactory transduction_Homo sapiens_hsa047401.21471445
61Folate biosynthesis_Homo sapiens_hsa007901.21009397
62RNA transport_Homo sapiens_hsa030131.19663551
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19527808
64Gastric acid secretion_Homo sapiens_hsa049711.17628382
65Fanconi anemia pathway_Homo sapiens_hsa034601.15752129
66Nicotine addiction_Homo sapiens_hsa050331.13319277
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.12733316
68Purine metabolism_Homo sapiens_hsa002301.07640673
69Circadian entrainment_Homo sapiens_hsa047131.07042926
70Salivary secretion_Homo sapiens_hsa049701.06908464
71Peroxisome_Homo sapiens_hsa041461.04268186
72Glutathione metabolism_Homo sapiens_hsa004800.99177701
73Regulation of autophagy_Homo sapiens_hsa041400.96097430
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95910356
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95063054
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94209063
77Fatty acid elongation_Homo sapiens_hsa000620.92262103
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.89060955
79Long-term potentiation_Homo sapiens_hsa047200.88503820
80Dopaminergic synapse_Homo sapiens_hsa047280.88338450
81Insulin secretion_Homo sapiens_hsa049110.86105238
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.85141364
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84445198
84Amphetamine addiction_Homo sapiens_hsa050310.83937728
85Morphine addiction_Homo sapiens_hsa050320.83933894
86Non-homologous end-joining_Homo sapiens_hsa034500.82388692
87Cocaine addiction_Homo sapiens_hsa050300.81252346
88Metabolic pathways_Homo sapiens_hsa011000.80653325
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80281347
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79362893
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79199690
92Glucagon signaling pathway_Homo sapiens_hsa049220.79000456
93beta-Alanine metabolism_Homo sapiens_hsa004100.78040577
94Long-term depression_Homo sapiens_hsa047300.77351815
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76227863
96Starch and sucrose metabolism_Homo sapiens_hsa005000.75075076
97Sulfur metabolism_Homo sapiens_hsa009200.74860139
98Pentose phosphate pathway_Homo sapiens_hsa000300.74705780
99Gap junction_Homo sapiens_hsa045400.74112320
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.71952394
101Vitamin digestion and absorption_Homo sapiens_hsa049770.69198438
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.67423915
103Allograft rejection_Homo sapiens_hsa053300.66957804
104Type I diabetes mellitus_Homo sapiens_hsa049400.66834199
105Chemical carcinogenesis_Homo sapiens_hsa052040.65616844
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64888432
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.64346985
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64196545
109Fat digestion and absorption_Homo sapiens_hsa049750.64175883
110Insulin resistance_Homo sapiens_hsa049310.62208066
111Rheumatoid arthritis_Homo sapiens_hsa053230.60519611
112GnRH signaling pathway_Homo sapiens_hsa049120.60397403
113Retinol metabolism_Homo sapiens_hsa008300.60337150
114Cholinergic synapse_Homo sapiens_hsa047250.59796596
115ABC transporters_Homo sapiens_hsa020100.59058480
116Thyroid hormone synthesis_Homo sapiens_hsa049180.58486744
117Type II diabetes mellitus_Homo sapiens_hsa049300.57538332
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56856889
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56455374
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56114719
121Insulin signaling pathway_Homo sapiens_hsa049100.56103388
122Autoimmune thyroid disease_Homo sapiens_hsa053200.55794710
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55745613
124Linoleic acid metabolism_Homo sapiens_hsa005910.55575079
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54892575
126cAMP signaling pathway_Homo sapiens_hsa040240.54734037
127Galactose metabolism_Homo sapiens_hsa000520.54183997
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.53831064
129Arginine and proline metabolism_Homo sapiens_hsa003300.53178437
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.52817931
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52625414
132N-Glycan biosynthesis_Homo sapiens_hsa005100.50765377
133Oxytocin signaling pathway_Homo sapiens_hsa049210.50494804
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50019049
135Tyrosine metabolism_Homo sapiens_hsa003500.48803703
136Estrogen signaling pathway_Homo sapiens_hsa049150.48758857
137Arachidonic acid metabolism_Homo sapiens_hsa005900.48687877
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48015650
139Calcium signaling pathway_Homo sapiens_hsa040200.46921531
140Mineral absorption_Homo sapiens_hsa049780.46825659
141Pancreatic secretion_Homo sapiens_hsa049720.46696146
142Taste transduction_Homo sapiens_hsa047420.46677203
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45534894
144mTOR signaling pathway_Homo sapiens_hsa041500.45376384
145Selenocompound metabolism_Homo sapiens_hsa004500.44175338
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44068391
147Renin secretion_Homo sapiens_hsa049240.43035907
148Caffeine metabolism_Homo sapiens_hsa002320.43008291
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.42749036
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42686596
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41781009
152Phenylalanine metabolism_Homo sapiens_hsa003600.41076531
153AMPK signaling pathway_Homo sapiens_hsa041520.40438329
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40148233
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37618254
156Graft-versus-host disease_Homo sapiens_hsa053320.37427917
157Vibrio cholerae infection_Homo sapiens_hsa051100.33300064
158Epstein-Barr virus infection_Homo sapiens_hsa051690.33132116
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.31016964
160Other glycan degradation_Homo sapiens_hsa005110.29441329
161Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26904515
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.22004894
163Ether lipid metabolism_Homo sapiens_hsa005650.21358287
164mRNA surveillance pathway_Homo sapiens_hsa030150.19973872
165p53 signaling pathway_Homo sapiens_hsa041150.19172413
166Cell cycle_Homo sapiens_hsa041100.17805705
167Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16964887
168Steroid biosynthesis_Homo sapiens_hsa001000.16052269

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