PRICKLE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.45491967
2translational termination (GO:0006415)6.17938317
3ribosomal small subunit biogenesis (GO:0042274)5.79937550
4ribosomal small subunit assembly (GO:0000028)5.74212483
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39659950
6ribosomal large subunit biogenesis (GO:0042273)5.28784702
7protein targeting to ER (GO:0045047)5.24585569
8cotranslational protein targeting to membrane (GO:0006613)5.22980452
9translational elongation (GO:0006414)5.09053021
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.99327992
11protein localization to endoplasmic reticulum (GO:0070972)4.86411742
12viral life cycle (GO:0019058)4.77470705
13cellular protein complex disassembly (GO:0043624)4.59350638
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.55754925
15maturation of SSU-rRNA (GO:0030490)4.34455244
16translational initiation (GO:0006413)4.29710746
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.28501333
18GDP-mannose metabolic process (GO:0019673)4.01956361
19negative regulation of cell size (GO:0045792)3.92510964
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.87342145
21protein complex disassembly (GO:0043241)3.85415965
22natural killer cell activation involved in immune response (GO:0002323)3.78801763
23NIK/NF-kappaB signaling (GO:0038061)3.70020296
24cytidine metabolic process (GO:0046087)3.66604658
25cytidine catabolic process (GO:0006216)3.66604658
26cytidine deamination (GO:0009972)3.66604658
27macromolecular complex disassembly (GO:0032984)3.64303623
28daunorubicin metabolic process (GO:0044597)3.58190049
29polyketide metabolic process (GO:0030638)3.58190049
30doxorubicin metabolic process (GO:0044598)3.58190049
31regulation of defense response to virus by host (GO:0050691)3.56311800
32base-excision repair, AP site formation (GO:0006285)3.54863473
33cellular extravasation (GO:0045123)3.45293667
34protein targeting to membrane (GO:0006612)3.40858826
35positive regulation of histone deacetylation (GO:0031065)3.35856959
36positive regulation of chemokine secretion (GO:0090197)3.29598086
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.27660680
38ribonucleoprotein complex biogenesis (GO:0022613)3.26564018
39positive regulation of keratinocyte differentiation (GO:0045618)3.21678054
40desmosome organization (GO:0002934)3.20656751
41G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.18586335
42DNA deamination (GO:0045006)3.16617802
43mRNA catabolic process (GO:0006402)3.15288138
44translation (GO:0006412)3.13372751
45fructose metabolic process (GO:0006000)3.12503780
46negative regulation of B cell apoptotic process (GO:0002903)3.11103965
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08282312
48endothelium development (GO:0003158)3.04899247
49negative regulation of defense response to virus (GO:0050687)3.03420278
50anatomical structure regression (GO:0060033)3.01464094
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93066857
52regulation of chemokine secretion (GO:0090196)2.91264604
53RNA catabolic process (GO:0006401)2.90679490
54positive regulation of defense response to virus by host (GO:0002230)2.87707236
55superoxide anion generation (GO:0042554)2.87417004
56leukocyte degranulation (GO:0043299)2.79561649
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79502387
58tRNA modification (GO:0006400)2.77858995
59telomere maintenance via semi-conservative replication (GO:0032201)2.77788719
60Peyers patch development (GO:0048541)2.76546504
61mucosal-associated lymphoid tissue development (GO:0048537)2.76546504
62positive regulation of protein deacetylation (GO:0090312)2.75479293
63positive regulation of B cell differentiation (GO:0045579)2.69688034
64purinergic nucleotide receptor signaling pathway (GO:0035590)2.69579396
65B cell mediated immunity (GO:0019724)2.69031433
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68792895
67DNA replication checkpoint (GO:0000076)2.67709966
68proteasome assembly (GO:0043248)2.67010689
69pentose metabolic process (GO:0019321)2.66999938
70peptidyl-arginine omega-N-methylation (GO:0035247)2.66997879
71transcription from mitochondrial promoter (GO:0006390)2.66318708
72regulation of B cell apoptotic process (GO:0002902)2.66230135
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62912726
74DNA topological change (GO:0006265)2.62339610
75lipoxygenase pathway (GO:0019372)2.62178221
76telomere maintenance via recombination (GO:0000722)2.59922321
77phosphatidylglycerol biosynthetic process (GO:0006655)2.59024519
78proline biosynthetic process (GO:0006561)2.56979269
79negative regulation of response to biotic stimulus (GO:0002832)2.55211808
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.54806451
81purine deoxyribonucleotide catabolic process (GO:0009155)2.53993226
82carbohydrate phosphorylation (GO:0046835)2.53851932
83cellular component biogenesis (GO:0044085)2.53612408
84positive regulation of hair cycle (GO:0042635)2.53492192
85positive regulation of hair follicle development (GO:0051798)2.53492192
86chaperone mediated protein folding requiring cofactor (GO:0051085)2.53390188
87response to peptidoglycan (GO:0032494)2.53285645
88regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52995286
89mitochondrial RNA metabolic process (GO:0000959)2.52429035
90regulation of respiratory burst (GO:0060263)2.51092256
91cellular response to dsRNA (GO:0071359)2.50729038
92regulation of B cell differentiation (GO:0045577)2.50607735
93positive regulation of gamma-delta T cell activation (GO:0046645)2.49066961
94response to type I interferon (GO:0034340)2.49016908
95angiogenesis involved in wound healing (GO:0060055)2.48575651
96rRNA processing (GO:0006364)2.48347066
97immunoglobulin mediated immune response (GO:0016064)2.47321887
98autophagic vacuole fusion (GO:0000046)2.46425443
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46385567
100pentose-phosphate shunt (GO:0006098)2.46000804
101CENP-A containing nucleosome assembly (GO:0034080)2.45948181
102interferon-gamma production (GO:0032609)2.45236527
103pseudouridine synthesis (GO:0001522)2.44206977
104negative regulation of phagocytosis (GO:0050765)2.43350235
105meiotic chromosome segregation (GO:0045132)2.43148649
106pyrimidine nucleotide catabolic process (GO:0006244)2.42739021
107cellular response to type I interferon (GO:0071357)2.42713671
108type I interferon signaling pathway (GO:0060337)2.42713671
109mitotic recombination (GO:0006312)2.42412829
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.40191570
111termination of RNA polymerase III transcription (GO:0006386)2.40191570
112glucose catabolic process (GO:0006007)2.38944442
113chromatin remodeling at centromere (GO:0031055)2.38595195
114rRNA metabolic process (GO:0016072)2.37198516
115intra-S DNA damage checkpoint (GO:0031573)2.35743822
116snRNA metabolic process (GO:0016073)2.35698366
117telomere maintenance via telomere lengthening (GO:0010833)2.35497922
118sphingoid metabolic process (GO:0046519)2.35164815
119keratinocyte proliferation (GO:0043616)2.34463126
120positive regulation of epidermal cell differentiation (GO:0045606)2.34061688
121leukocyte aggregation (GO:0070486)2.33304283
122sulfur amino acid catabolic process (GO:0000098)2.33032001
123pyrimidine nucleoside catabolic process (GO:0046135)2.32975940
124lymph node development (GO:0048535)2.32883615
125regulation of B cell receptor signaling pathway (GO:0050855)2.32455698
126positive regulation of triglyceride biosynthetic process (GO:0010867)2.32363584
127positive regulation of interleukin-8 secretion (GO:2000484)2.31721381
128ribosome biogenesis (GO:0042254)2.31440509
129regulation of antigen processing and presentation (GO:0002577)2.29470303
130antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29090201
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29090201
132peptidyl-histidine modification (GO:0018202)2.28798079
133tumor necrosis factor-mediated signaling pathway (GO:0033209)2.28331255
134positive regulation of prostaglandin secretion (GO:0032308)2.28213128
135ncRNA 3-end processing (GO:0043628)2.28208191
136negative regulation of viral release from host cell (GO:1902187)2.27854371
137mitotic G1 DNA damage checkpoint (GO:0031571)2.27222191
138cellular response to zinc ion (GO:0071294)2.26800834
139actin nucleation (GO:0045010)2.26626118
140snRNA processing (GO:0016180)2.26241802
141DNA ligation (GO:0006266)2.25433667
142deoxyribose phosphate catabolic process (GO:0046386)2.25041390
143cellular response to exogenous dsRNA (GO:0071360)2.24618846
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.24504854
145deoxyribonucleotide catabolic process (GO:0009264)2.24309380
146DNA damage response, signal transduction resulting in transcription (GO:0042772)2.23371716
147DNA catabolic process, exonucleolytic (GO:0000738)2.23213085
148natural killer cell activation (GO:0030101)2.22823710
149positive regulation of antigen processing and presentation (GO:0002579)2.22588951
150DNA strand elongation involved in DNA replication (GO:0006271)2.22115099
151T cell lineage commitment (GO:0002360)2.21837221
152myeloid dendritic cell activation (GO:0001773)2.21677703
153pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.21422658
154positive regulation of respiratory burst (GO:0060267)2.21195989
155positive regulation of epidermis development (GO:0045684)2.21056902
156antigen processing and presentation of endogenous antigen (GO:0019883)2.20856007
157positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20553576
158tRNA methylation (GO:0030488)2.20167548
159nucleotide salvage (GO:0043173)2.19716780
160respiratory chain complex IV assembly (GO:0008535)2.19543452
161definitive hemopoiesis (GO:0060216)2.18457324
162dendritic cell chemotaxis (GO:0002407)2.17615837
163positive regulation of T cell apoptotic process (GO:0070234)2.16996860
164positive regulation of interleukin-1 beta secretion (GO:0050718)2.16165962
165DNA strand elongation (GO:0022616)2.16001919
166diol metabolic process (GO:0034311)2.15836692
167negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.15752727
168mitotic G1/S transition checkpoint (GO:0044819)2.15744812
169regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.15559500
170rRNA modification (GO:0000154)2.14960208
171modulation by virus of host process (GO:0019054)2.14718689
172pinocytosis (GO:0006907)2.14594602
173regulation of T cell mediated cytotoxicity (GO:0001914)2.14443614
174kinetochore organization (GO:0051383)2.13812482
175glucosamine-containing compound catabolic process (GO:1901072)2.13671384
176purine nucleotide salvage (GO:0032261)2.13652857
177positive regulation of protein homooligomerization (GO:0032464)2.13447434
178regulation of Cdc42 GTPase activity (GO:0043088)2.13286667
179RNA methylation (GO:0001510)2.12885491
180metallo-sulfur cluster assembly (GO:0031163)2.11790360
181iron-sulfur cluster assembly (GO:0016226)2.11790360
182positive thymic T cell selection (GO:0045059)2.10733760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.34669546
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.31183188
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.38160780
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.15799802
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.10542469
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76492605
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71609783
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54162957
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53233803
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.53122267
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.51273110
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48316337
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41087917
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36296502
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35856309
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35451547
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31481639
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30196688
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25409157
20LXR_22292898_ChIP-Seq_THP-1_Human2.15533132
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15310549
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14854443
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10492388
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08886098
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.08676027
26P68_20966046_ChIP-Seq_HELA_Human2.02457252
27BCL6_27268052_Chip-Seq_Bcells_Human1.97653358
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97054711
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95337967
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93149147
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.90112357
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.89577572
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.87772465
34SPI1_23547873_ChIP-Seq_NB4_Human1.85953090
35DCP1A_22483619_ChIP-Seq_HELA_Human1.85741898
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85594539
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84016576
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83085984
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.82702303
40BCOR_27268052_Chip-Seq_Bcells_Human1.81420838
41CIITA_25753668_ChIP-Seq_RAJI_Human1.75280747
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73681949
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73204520
44FOXP3_21729870_ChIP-Seq_TREG_Human1.71392039
45VDR_23849224_ChIP-Seq_CD4+_Human1.69992007
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.69879635
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69727612
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68411651
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66876238
50RACK7_27058665_Chip-Seq_MCF-7_Human1.66328757
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66280338
52TTF2_22483619_ChIP-Seq_HELA_Human1.66209085
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62754209
54XRN2_22483619_ChIP-Seq_HELA_Human1.60255825
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59293406
56E2F1_20622854_ChIP-Seq_HELA_Human1.59070585
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58543564
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58290945
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56824035
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.55324712
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55142883
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54235840
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.53794992
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52026420
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.51006983
66GABP_19822575_ChIP-Seq_HepG2_Human1.50605433
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50284112
68ELK1_19687146_ChIP-ChIP_HELA_Human1.50010136
69MAF_26560356_Chip-Seq_TH1_Human1.49264126
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47121572
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47036292
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46555763
73PHF8_20622854_ChIP-Seq_HELA_Human1.46381136
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45900004
75VDR_21846776_ChIP-Seq_THP-1_Human1.45143523
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44948195
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44277144
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44205082
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43717146
80* NCOR1_26117541_ChIP-Seq_K562_Human1.40930735
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40223388
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39637760
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39068135
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.38609304
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38535598
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36854749
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.36162004
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.34723613
89MYB_26560356_Chip-Seq_TH1_Human1.34437834
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33657153
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.32998997
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32766744
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32431638
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31844366
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30448309
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29744953
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.28964485
98MYB_26560356_Chip-Seq_TH2_Human1.27728177
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27659791
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27423485
101* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27031212
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26835484
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26422907
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26380380
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26287470
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25686425
107KDM5A_27292631_Chip-Seq_BREAST_Human1.25055510
108MYC_22102868_ChIP-Seq_BL_Human1.24292234
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24165227
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24053901
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.23705081
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22739262
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.22675024
114CTCF_21964334_Chip-Seq_Bcells_Human1.22549856
115P300_27268052_Chip-Seq_Bcells_Human1.22431454
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22033524
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.21700479
118KDM2B_26808549_Chip-Seq_DND41_Human1.21598431
119NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20004622
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19869516
121UTX_26944678_Chip-Seq_JUKART_Human1.18435711
122CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17385228
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17211264
124E2F1_21310950_ChIP-Seq_MCF-7_Human1.16081463
125VDR_24763502_ChIP-Seq_THP-1_Human1.15602971
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14658552
127ATF3_27146783_Chip-Seq_COLON_Human1.14045846
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13892796
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.13453854
130SMC4_20622854_ChIP-Seq_HELA_Human1.13225373
131PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12535626
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11993470
133MAF_26560356_Chip-Seq_TH2_Human1.11471107
134TFEB_21752829_ChIP-Seq_HELA_Human1.11297553
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10381246
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.10125991
137* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09753443
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08843672
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08480756
140CTCF_20526341_ChIP-Seq_ESCs_Human1.08479994
141MYC_18940864_ChIP-ChIP_HL60_Human1.07070789
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05265526
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03913265
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03913265
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03764182
146KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98355228
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98355228
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98355228
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95595273
150* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91759060
151TCF7_22412390_ChIP-Seq_EML_Mouse0.91438747
152ZNF263_19887448_ChIP-Seq_K562_Human0.89121110
153PU_27001747_Chip-Seq_BMDM_Mouse0.87609667
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85117244
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83569760
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83183427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.95075494
2MP0002877_abnormal_melanocyte_morpholog4.26343626
3MP0005451_abnormal_body_composition3.17327759
4MP0003941_abnormal_skin_development3.13213812
5MP0003828_pulmonary_edema2.52660249
6MP0003303_peritoneal_inflammation2.50582881
7MP0005083_abnormal_biliary_tract2.48733141
8MP0002138_abnormal_hepatobiliary_system2.47608929
9MP0003724_increased_susceptibility_to2.41244060
10MP0003763_abnormal_thymus_physiology2.31280256
11MP0008260_abnormal_autophagy2.21495461
12MP0001835_abnormal_antigen_presentation2.21446962
13MP0005084_abnormal_gallbladder_morpholo2.13088603
14MP0003436_decreased_susceptibility_to2.10338198
15MP0002396_abnormal_hematopoietic_system2.08953027
16MP0003693_abnormal_embryo_hatching2.00453303
17MP0002148_abnormal_hypersensitivity_rea1.93488046
18MP0000685_abnormal_immune_system1.92058872
19MP0001790_abnormal_immune_system1.88297277
20MP0005387_immune_system_phenotype1.88297277
21MP0000372_irregular_coat_pigmentation1.82260290
22MP0001348_abnormal_lacrimal_gland1.76465753
23MP0001800_abnormal_humoral_immune1.76122085
24MP0005671_abnormal_response_to1.69935789
25MP0009785_altered_susceptibility_to1.69635264
26MP0004381_abnormal_hair_follicle1.69191215
27MP0008007_abnormal_cellular_replicative1.65223028
28MP0002452_abnormal_antigen_presenting1.64366797
29MP0000490_abnormal_crypts_of1.62859925
30MP0002653_abnormal_ependyma_morphology1.59690801
31MP0010155_abnormal_intestine_physiology1.55394301
32MP0005000_abnormal_immune_tolerance1.54408221
33MP0002132_abnormal_respiratory_system1.54163529
34MP0005025_abnormal_response_to1.53096002
35MP0002420_abnormal_adaptive_immunity1.52871628
36MP0008995_early_reproductive_senescence1.52311656
37MP0008004_abnormal_stomach_pH1.51554242
38MP0001819_abnormal_immune_cell1.51537015
39MP0000015_abnormal_ear_pigmentation1.49864274
40MP0002928_abnormal_bile_duct1.49308985
41MP0002723_abnormal_immune_serum1.43959664
42MP0001853_heart_inflammation1.41674103
43MP0009333_abnormal_splenocyte_physiolog1.41666548
44MP0002277_abnormal_respiratory_mucosa1.41620535
45MP0003806_abnormal_nucleotide_metabolis1.40984458
46MP0001879_abnormal_lymphatic_vessel1.40429970
47MP0010094_abnormal_chromosome_stability1.40365230
48MP0003252_abnormal_bile_duct1.40032928
49MP0002796_impaired_skin_barrier1.39852179
50MP0002419_abnormal_innate_immunity1.39632149
51MP0009278_abnormal_bone_marrow1.37625522
52MP0005464_abnormal_platelet_physiology1.36924132
53MP0000371_diluted_coat_color1.35332698
54MP0003646_muscle_fatigue1.34186308
55MP0002098_abnormal_vibrissa_morphology1.33790464
56MP0005408_hypopigmentation1.33720810
57MP0002405_respiratory_system_inflammati1.31823060
58MP0002166_altered_tumor_susceptibility1.30859113
59MP0005645_abnormal_hypothalamus_physiol1.29765813
60MP0000858_altered_metastatic_potential1.28559264
61MP0003300_gastrointestinal_ulcer1.26820557
62MP0002398_abnormal_bone_marrow1.26554822
63MP0004957_abnormal_blastocyst_morpholog1.25633011
64MP0002060_abnormal_skin_morphology1.25388451
65MP0001873_stomach_inflammation1.22225676
66MP0003453_abnormal_keratinocyte_physiol1.22141033
67MP0002095_abnormal_skin_pigmentation1.21915401
68MP0005174_abnormal_tail_pigmentation1.20461902
69MP0000678_abnormal_parathyroid_gland1.19196533
70MP0009840_abnormal_foam_cell1.17880959
71MP0005501_abnormal_skin_physiology1.17539554
72MP0000716_abnormal_immune_system1.16444950
73MP0003111_abnormal_nucleus_morphology1.16423106
74MP0003045_fibrosis1.15985018
75MP0001216_abnormal_epidermal_layer1.12503646
76MP0006036_abnormal_mitochondrial_physio1.12392766
77MP0005076_abnormal_cell_differentiation1.11400470
78MP0001545_abnormal_hematopoietic_system1.10585231
79MP0005397_hematopoietic_system_phenotyp1.10585231
80MP0005670_abnormal_white_adipose1.09583322
81MP0004145_abnormal_muscle_electrophysio1.09119944
82MP0005171_absent_coat_pigmentation1.08940028
83MP0002006_tumorigenesis1.08602499
84MP0002722_abnormal_immune_system1.07544410
85MP0003077_abnormal_cell_cycle1.07303477
86MP0000689_abnormal_spleen_morphology1.07237500
87MP0000613_abnormal_salivary_gland1.06606972
88MP0003172_abnormal_lysosome_physiology1.06025983
89MP0004808_abnormal_hematopoietic_stem1.05634419
90MP0000703_abnormal_thymus_morphology1.05596651
91MP0005075_abnormal_melanosome_morpholog1.04373369
92MP0006035_abnormal_mitochondrial_morpho1.03437781
93MP0001661_extended_life_span1.03120908
94MP0002429_abnormal_blood_cell1.02954283
95MP0004233_abnormal_muscle_weight1.02787586
96MP0009931_abnormal_skin_appearance1.02177793
97MP0005310_abnormal_salivary_gland1.01827365
98MP0005330_cardiomyopathy1.01373901
99MP0008932_abnormal_embryonic_tissue1.01335550
100MP0003566_abnormal_cell_adhesion0.99915401
101MP0002933_joint_inflammation0.99613337
102MP0000750_abnormal_muscle_regeneration0.99507289
103MP0008058_abnormal_DNA_repair0.97843569
104MP0005058_abnormal_lysosome_morphology0.97638985
105MP0003786_premature_aging0.96906223
106MP0000358_abnormal_cell_content/0.96812356
107MP0001845_abnormal_inflammatory_respons0.95752653
108MP0004947_skin_inflammation0.94542512
109MP0001533_abnormal_skeleton_physiology0.94015340
110MP0005220_abnormal_exocrine_pancreas0.91973406
111MP0003315_abnormal_perineum_morphology0.91476838
112MP0005410_abnormal_fertilization0.91331378
113MP0005275_abnormal_skin_tensile0.90821490
114MP0002009_preneoplasia0.89779545
115MP0010368_abnormal_lymphatic_system0.89265638
116MP0000566_synostosis0.88081694
117MP0000538_abnormal_urinary_bladder0.87543518
118MP0001986_abnormal_taste_sensitivity0.86579903
119MP0008469_abnormal_protein_level0.85737826
120MP0000609_abnormal_liver_physiology0.85682395
121MP0001542_abnormal_bone_strength0.84778198
122MP0000579_abnormal_nail_morphology0.84642129
123MP0000003_abnormal_adipose_tissue0.83367213
124MP0005390_skeleton_phenotype0.82734275
125MP0001243_abnormal_dermal_layer0.81582132
126MP0009764_decreased_sensitivity_to0.80511240
127MP0003448_altered_tumor_morphology0.80506076
128MP0001663_abnormal_digestive_system0.80399195
129MP0000343_altered_response_to0.79985108
130MP0004133_heterotaxia0.79330559
131MP0002019_abnormal_tumor_incidence0.79323213
132MP0004185_abnormal_adipocyte_glucose0.78884001
133MP0000465_gastrointestinal_hemorrhage0.78560604
134MP0001191_abnormal_skin_condition0.76406144
135MP0001881_abnormal_mammary_gland0.75561749
136MP0000749_muscle_degeneration0.75279242
137MP0003866_abnormal_defecation0.75022923
138MP0001346_abnormal_lacrimal_gland0.74569806
139MP0001764_abnormal_homeostasis0.72937572
140MP0008875_abnormal_xenobiotic_pharmacok0.72852757
141MP0003183_abnormal_peptide_metabolism0.72770146
142MP0002075_abnormal_coat/hair_pigmentati0.72394079
143MP0000377_abnormal_hair_follicle0.70843217
144MP0009697_abnormal_copulation0.69979218
145MP0001919_abnormal_reproductive_system0.69634212
146MP0000767_abnormal_smooth_muscle0.69619279
147MP0010771_integument_phenotype0.69262577
148MP0001851_eye_inflammation0.68845766
149MP0006292_abnormal_olfactory_placode0.64488814

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.83745373
2Abnormal hemoglobin (HP:0011902)4.71822170
3Cholecystitis (HP:0001082)3.59683503
4Abnormal gallbladder physiology (HP:0012438)3.59683503
5Eczematoid dermatitis (HP:0000976)3.47308265
6Congenital, generalized hypertrichosis (HP:0004540)3.40841428
7Alveolar cell carcinoma (HP:0006519)3.30815728
8Hypertensive crisis (HP:0100735)3.26261689
9Recurrent abscess formation (HP:0002722)3.24910818
10Macrocytic anemia (HP:0001972)3.15384016
11Pallor (HP:0000980)3.11529574
12Increased serum ferritin (HP:0003281)3.07959662
13Abnormal number of erythroid precursors (HP:0012131)2.95984740
14Abnormality of cells of the erythroid lineage (HP:0012130)2.95657785
15Exertional dyspnea (HP:0002875)2.95449287
16Squamous cell carcinoma (HP:0002860)2.87781597
17Cheilitis (HP:0100825)2.87030077
18Easy fatigability (HP:0003388)2.84894940
19Severe visual impairment (HP:0001141)2.82554225
20Chest pain (HP:0100749)2.82169494
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81831834
22Recurrent bacterial skin infections (HP:0005406)2.79762653
23Ventricular tachycardia (HP:0004756)2.77612293
24Neoplasm of the tracheobronchial system (HP:0100552)2.72526215
25Attenuation of retinal blood vessels (HP:0007843)2.69934847
26Chromsome breakage (HP:0040012)2.64506797
27Obstructive lung disease (HP:0006536)2.62572610
28Chronic obstructive pulmonary disease (HP:0006510)2.62572610
29Sparse eyelashes (HP:0000653)2.51452306
30Abnormality of transition element cation homeostasis (HP:0011030)2.49984846
31Thrombocytosis (HP:0001894)2.49607734
32Pulmonary infiltrates (HP:0002113)2.48623345
33Pustule (HP:0200039)2.47516636
34Abnormality of iron homeostasis (HP:0011031)2.46967077
35Recurrent fungal infections (HP:0002841)2.45447280
36Premature graying of hair (HP:0002216)2.45357477
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41287048
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39308370
39Myositis (HP:0100614)2.37958705
40Elevated erythrocyte sedimentation rate (HP:0003565)2.34166698
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.32789223
42Lip pit (HP:0100267)2.31062231
43Petechiae (HP:0000967)2.30688047
44Chronic mucocutaneous candidiasis (HP:0002728)2.29899710
45Recurrent cutaneous fungal infections (HP:0011370)2.29899710
46Abnormality of the preputium (HP:0100587)2.29335240
47Myopathic facies (HP:0002058)2.29112900
48Breast hypoplasia (HP:0003187)2.26987415
49Onycholysis (HP:0001806)2.26177667
50Reticulocytosis (HP:0001923)2.25838835
51Woolly hair (HP:0002224)2.24521594
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22651729
53Distal lower limb muscle weakness (HP:0009053)2.22130153
54Pendular nystagmus (HP:0012043)2.21998018
55Increased hepatocellular lipid droplets (HP:0006565)2.21925924
56J-shaped sella turcica (HP:0002680)2.21711245
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19744000
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19744000
59Trismus (HP:0000211)2.18693071
60Absent thumb (HP:0009777)2.18465450
61Aplastic anemia (HP:0001915)2.18088962
62Congenital sensorineural hearing impairment (HP:0008527)2.16529577
63Congenital stationary night blindness (HP:0007642)2.15996455
64Hepatocellular necrosis (HP:0001404)2.15700530
65Stomatitis (HP:0010280)2.15696899
66Nonimmune hydrops fetalis (HP:0001790)2.14525648
67Cholelithiasis (HP:0001081)2.12658243
68Sparse scalp hair (HP:0002209)2.10130620
69Ridged nail (HP:0001807)2.09386906
70Triphalangeal thumb (HP:0001199)2.08655740
71Fatigable weakness (HP:0003473)2.08227488
72Abnormality of the neuromuscular junction (HP:0003398)2.08227488
73Testicular atrophy (HP:0000029)2.06578086
74Meningitis (HP:0001287)2.06111276
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05900191
76Agammaglobulinemia (HP:0004432)2.05144226
77Panhypogammaglobulinemia (HP:0003139)2.04238345
78Rough bone trabeculation (HP:0100670)2.03923434
79Alopecia of scalp (HP:0002293)2.03573851
80Unilateral renal agenesis (HP:0000122)2.03539377
81Recurrent skin infections (HP:0001581)2.02236308
82Lipid accumulation in hepatocytes (HP:0006561)2.02011166
83Recurrent viral infections (HP:0004429)2.01219326
84Entropion (HP:0000621)2.01152228
85Dry hair (HP:0011359)1.99848178
86Progressive muscle weakness (HP:0003323)1.99590632
87Increased intramyocellular lipid droplets (HP:0012240)1.99227346
88Hepatic necrosis (HP:0002605)1.99171848
89Oral leukoplakia (HP:0002745)1.98805298
90Prolonged bleeding time (HP:0003010)1.97537489
91Mediastinal lymphadenopathy (HP:0100721)1.97107905
92Reduced subcutaneous adipose tissue (HP:0003758)1.97008240
93Hyperacusis (HP:0010780)1.96729826
94Atelectasis (HP:0100750)1.95610570
95Cellulitis (HP:0100658)1.95220988
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95191197
97Chronic otitis media (HP:0000389)1.95097011
98Abnormal rod and cone electroretinograms (HP:0008323)1.94530166
99Ocular albinism (HP:0001107)1.92327769
100Increased muscle lipid content (HP:0009058)1.91378786
101Aplasia/Hypoplasia of the patella (HP:0006498)1.91314199
102Persistence of primary teeth (HP:0006335)1.91163318
103Increased cerebral lipofuscin (HP:0011813)1.90412032
104Prostate neoplasm (HP:0100787)1.90094818
105Exercise-induced myalgia (HP:0003738)1.89297833
106Aplasia/Hypoplasia of the thymus (HP:0010515)1.88250972
107Reduced antithrombin III activity (HP:0001976)1.87260007
108Abnormality of nail color (HP:0100643)1.87026509
109Nail dystrophy (HP:0008404)1.85087268
110Inflammation of the large intestine (HP:0002037)1.84995709
111Ragged-red muscle fibers (HP:0003200)1.84268470
112Urticaria (HP:0001025)1.84137725
113Poikiloderma (HP:0001029)1.82200536
114Granulocytopenia (HP:0001913)1.82069444
115Abnormality of the axillary hair (HP:0100134)1.81969414
116Abnormality of secondary sexual hair (HP:0009888)1.81969414
117Increased IgE level (HP:0003212)1.81503045
118Natal tooth (HP:0000695)1.81349812
119Sudden death (HP:0001699)1.81026984
120Renal Fanconi syndrome (HP:0001994)1.80974007
121Abnormal gallbladder morphology (HP:0012437)1.80823541
122Periodontitis (HP:0000704)1.80494182
123Retinal dysplasia (HP:0007973)1.79945025
124Abnormality of T cells (HP:0002843)1.79492617
125Abnormality of T cell physiology (HP:0011840)1.79386201
126Abnormal protein glycosylation (HP:0012346)1.78908547
127Abnormal glycosylation (HP:0012345)1.78908547
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78908547
129Abnormal protein N-linked glycosylation (HP:0012347)1.78908547
130Right ventricular cardiomyopathy (HP:0011663)1.78479901
131Erythema (HP:0010783)1.77704228
132IgM deficiency (HP:0002850)1.77653581
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.77539155
134Respiratory difficulties (HP:0002880)1.77375495
135Rhabdomyolysis (HP:0003201)1.76820485
136Areflexia of lower limbs (HP:0002522)1.76123891
137Premature loss of primary teeth (HP:0006323)1.75998761
138Patellar aplasia (HP:0006443)1.75936366
139Lipoatrophy (HP:0100578)1.75556593
140Seborrheic dermatitis (HP:0001051)1.75043741
141Recurrent gram-negative bacterial infections (HP:0005420)1.74638947
142Emphysema (HP:0002097)1.74081880
143Vacuolated lymphocytes (HP:0001922)1.73946557
144Type I transferrin isoform profile (HP:0003642)1.73885245
145Lymphangioma (HP:0100764)1.73761485
146Gingivitis (HP:0000230)1.73433507
147Pulmonary fibrosis (HP:0002206)1.73090081
148Clubbing of toes (HP:0100760)1.73031066
149Acute hepatic failure (HP:0006554)1.72694606
150Gastrointestinal inflammation (HP:0004386)1.72165782
151Abnormality of glycolipid metabolism (HP:0010969)1.71434759
152Abnormality of liposaccharide metabolism (HP:0010968)1.71434759
153Abnormality of glycosphingolipid metabolism (HP:0004343)1.71434759
154Gastrointestinal infarctions (HP:0005244)1.71269799
155Hypoplasia of the uterus (HP:0000013)1.70667523
156Abnormality of lateral ventricle (HP:0030047)1.70137995
157Amniotic constriction ring (HP:0009775)1.69175913
158Abnormality of placental membranes (HP:0011409)1.69175913
159Abnormality of the prostate (HP:0008775)1.68761168
160Abnormality of chromosome stability (HP:0003220)1.68147079
161Sparse lateral eyebrow (HP:0005338)1.68031323
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.67814454
163Ureteral stenosis (HP:0000071)1.66236264
164Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66124125
165Myoglobinuria (HP:0002913)1.66104921
166Autoimmune hemolytic anemia (HP:0001890)1.65941628
167Muscle fiber atrophy (HP:0100295)1.65531446
168Progressive microcephaly (HP:0000253)1.65036089
169Premature rupture of membranes (HP:0001788)1.64360889
170Plantar hyperkeratosis (HP:0007556)1.63416230
171Myelodysplasia (HP:0002863)1.63297574
172Skin ulcer (HP:0200042)1.63232123
173Abnormality of macrophages (HP:0004311)1.63198600
174Ependymoma (HP:0002888)1.62939879
175Depressed nasal ridge (HP:0000457)1.62622702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.71809172
2TLK13.50539700
3IRAK33.27152028
4VRK23.25551335
5IRAK43.14027355
6TAF13.12763934
7SMG12.98799594
8EIF2AK12.87588805
9PIM22.59384770
10MUSK2.31913241
11MAP4K12.26293438
12SIK12.24946825
13MST1R2.23256639
14NEK92.19637361
15TRIB32.13781153
16PRKCI2.08701560
17TEC2.06075932
18BLK1.95527962
19BUB11.89653186
20BCKDK1.87075174
21EPHA21.82476291
22TXK1.72262318
23NLK1.68589263
24FLT31.65464811
25TIE11.63586780
26MAP3K141.59173047
27IRAK11.53982489
28EEF2K1.53163500
29MAPKAPK31.43171124
30NUAK11.42648578
31IKBKE1.35473814
32RPS6KA41.35011794
33PRKD21.34773618
34IKBKB1.33193006
35ZAK1.30482884
36MAP3K111.28830642
37TBK11.26308152
38MAP3K31.23752339
39KDR1.23414408
40IRAK21.22359491
41GRK61.21609239
42EPHB11.21245261
43CDK81.19594791
44JAK31.17466195
45EIF2AK21.15382981
46ZAP701.12031715
47PIM11.09948997
48TYK21.09872157
49CSK1.09544796
50VRK11.07805213
51BTK1.07728120
52KIT1.07037773
53STK101.07000173
54DMPK1.06115460
55WEE11.05710998
56TAOK31.05049992
57TGFBR21.04973755
58CCNB11.03991321
59TRPM71.03755517
60SIK31.02224269
61PBK1.02102550
62DYRK1B1.01953325
63NME10.99490891
64TNK20.98400301
65TESK20.98250663
66WNK40.97553031
67TESK10.97011837
68FES0.96751747
69PRPF4B0.95037010
70MAP2K30.94778739
71SIK20.91658318
72ICK0.90970722
73SRPK10.90858071
74PIK3CG0.90562683
75CLK10.89645672
76RPS6KB20.88605079
77MST40.88075135
78STK40.87873148
79MKNK20.86308547
80RPS6KA20.85657318
81PKN20.85053294
82CAMK1D0.84385867
83AURKB0.83042090
84DYRK30.80896518
85PLK40.79804800
86MAP3K10.79349690
87BMX0.77914553
88CDK70.76737796
89ATR0.76649684
90EIF2AK30.74897565
91TTK0.73726185
92TTN0.72695953
93GRK70.71108471
94AURKA0.70277532
95LCK0.70172872
96OBSCN0.69612041
97CHUK0.69057650
98STK160.68800871
99BRSK20.67714709
100DAPK10.66654575
101YES10.66579612
102MATK0.66359910
103NEK20.65534940
104PTK60.65149439
105MAP3K50.64221797
106CDK90.62942494
107RIPK40.62710402
108GRK10.62639301
109LYN0.62002295
110ADRBK20.61884292
111TAOK10.60997910
112MAP3K80.60783815
113PLK10.60608336
114TAOK20.59653747
115CSF1R0.58869009
116CHEK20.58443645
117MYLK0.57992069
118MAPK110.57842333
119EPHA30.57787312
120MAP2K20.56424439
121CDK60.56002999
122CDK120.55837619
123ACVR1B0.55096204
124ITK0.54558860
125RPS6KL10.54390069
126RPS6KC10.54390069
127RPS6KA60.53437641
128LIMK10.53436126
129MAP2K60.53405391
130SYK0.53158899
131MAPK40.52834718
132LMTK20.51885635
133MKNK10.51746611
134PTK2B0.49235556
135RPS6KA50.47638254
136MARK30.47112727
137FGFR30.46920427
138MAPKAPK20.45381710
139HCK0.45100324
140JAK10.45036947
141MAPKAPK50.43808663
142TGFBR10.43187817
143MTOR0.41877392
144ERN10.40371269
145MET0.39286221
146CDK40.38543910
147PAK40.38472101
148PHKG10.34684031
149PHKG20.34684031
150ARAF0.31165195

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.25011787
2Fructose and mannose metabolism_Homo sapiens_hsa000513.90815109
3Homologous recombination_Homo sapiens_hsa034403.02068443
4DNA replication_Homo sapiens_hsa030302.87420234
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.46837006
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36832508
7RNA polymerase_Homo sapiens_hsa030202.35580713
8Primary immunodeficiency_Homo sapiens_hsa053402.34077970
9Mismatch repair_Homo sapiens_hsa034302.30500246
10Base excision repair_Homo sapiens_hsa034102.15828255
11Pentose phosphate pathway_Homo sapiens_hsa000302.12959929
12Sulfur metabolism_Homo sapiens_hsa009201.94980306
13Protein export_Homo sapiens_hsa030601.91350116
14Fanconi anemia pathway_Homo sapiens_hsa034601.89918325
15Galactose metabolism_Homo sapiens_hsa000521.89763469
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81734111
17Spliceosome_Homo sapiens_hsa030401.69845807
18Pyrimidine metabolism_Homo sapiens_hsa002401.67668228
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66581847
20Herpes simplex infection_Homo sapiens_hsa051681.65285298
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.62711867
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60276688
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.60010049
24Leishmaniasis_Homo sapiens_hsa051401.59698471
25Nucleotide excision repair_Homo sapiens_hsa034201.57570389
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54380859
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53210436
28Hematopoietic cell lineage_Homo sapiens_hsa046401.50076208
29p53 signaling pathway_Homo sapiens_hsa041151.42264503
30One carbon pool by folate_Homo sapiens_hsa006701.40413363
31Non-homologous end-joining_Homo sapiens_hsa034501.40167553
32Measles_Homo sapiens_hsa051621.39578360
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.36960552
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29445924
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29143079
36Antigen processing and presentation_Homo sapiens_hsa046121.26671248
37Proteasome_Homo sapiens_hsa030501.26128333
38Basal transcription factors_Homo sapiens_hsa030221.23490705
39Cell cycle_Homo sapiens_hsa041101.21965644
40Biosynthesis of amino acids_Homo sapiens_hsa012301.21152803
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18379937
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11317381
43RNA degradation_Homo sapiens_hsa030181.10117053
44Osteoclast differentiation_Homo sapiens_hsa043801.08989874
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07553955
46Viral myocarditis_Homo sapiens_hsa054161.06418565
47Legionellosis_Homo sapiens_hsa051341.05194568
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03968050
49Pertussis_Homo sapiens_hsa051331.03514475
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03352826
51Graft-versus-host disease_Homo sapiens_hsa053321.02905094
52Other glycan degradation_Homo sapiens_hsa005111.01581570
53Epstein-Barr virus infection_Homo sapiens_hsa051691.00864411
54Folate biosynthesis_Homo sapiens_hsa007901.00010699
55N-Glycan biosynthesis_Homo sapiens_hsa005100.99284931
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.98189542
57B cell receptor signaling pathway_Homo sapiens_hsa046620.98007152
58Influenza A_Homo sapiens_hsa051640.97310290
59Acute myeloid leukemia_Homo sapiens_hsa052210.94498501
60RNA transport_Homo sapiens_hsa030130.94209418
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93946477
62Viral carcinogenesis_Homo sapiens_hsa052030.93441215
63Lysosome_Homo sapiens_hsa041420.93104233
64Malaria_Homo sapiens_hsa051440.92789683
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92322771
66Toxoplasmosis_Homo sapiens_hsa051450.89291124
67Sulfur relay system_Homo sapiens_hsa041220.89248345
68HTLV-I infection_Homo sapiens_hsa051660.89239817
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87851073
70Apoptosis_Homo sapiens_hsa042100.87590771
71Shigellosis_Homo sapiens_hsa051310.82083749
72Purine metabolism_Homo sapiens_hsa002300.80303255
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79783790
74Arachidonic acid metabolism_Homo sapiens_hsa005900.78872610
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78764976
76Type I diabetes mellitus_Homo sapiens_hsa049400.78698881
77Carbon metabolism_Homo sapiens_hsa012000.77971628
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77809685
79Hepatitis B_Homo sapiens_hsa051610.77764754
80T cell receptor signaling pathway_Homo sapiens_hsa046600.76177172
81Selenocompound metabolism_Homo sapiens_hsa004500.74185150
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73808916
83Parkinsons disease_Homo sapiens_hsa050120.72902390
84Allograft rejection_Homo sapiens_hsa053300.71879994
85Systemic lupus erythematosus_Homo sapiens_hsa053220.71215210
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70919223
87TNF signaling pathway_Homo sapiens_hsa046680.69854194
88Lysine degradation_Homo sapiens_hsa003100.64377665
89Tuberculosis_Homo sapiens_hsa051520.64232422
90Notch signaling pathway_Homo sapiens_hsa043300.64067674
91Small cell lung cancer_Homo sapiens_hsa052220.62898615
92Oxidative phosphorylation_Homo sapiens_hsa001900.60659014
93Hepatitis C_Homo sapiens_hsa051600.60567980
94Fatty acid elongation_Homo sapiens_hsa000620.59907539
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59102212
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58831948
97AMPK signaling pathway_Homo sapiens_hsa041520.56845347
98Bladder cancer_Homo sapiens_hsa052190.56769420
99Prolactin signaling pathway_Homo sapiens_hsa049170.56557446
100Sphingolipid metabolism_Homo sapiens_hsa006000.55210038
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54740295
102MicroRNAs in cancer_Homo sapiens_hsa052060.54503351
103Huntingtons disease_Homo sapiens_hsa050160.54420665
104Phototransduction_Homo sapiens_hsa047440.53471977
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53453029
106mTOR signaling pathway_Homo sapiens_hsa041500.51461607
107Platelet activation_Homo sapiens_hsa046110.51058756
108Phenylalanine metabolism_Homo sapiens_hsa003600.50962910
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.50594892
110HIF-1 signaling pathway_Homo sapiens_hsa040660.49628728
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47448865
112mRNA surveillance pathway_Homo sapiens_hsa030150.47398977
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47264729
114Metabolic pathways_Homo sapiens_hsa011000.45813092
115Thyroid cancer_Homo sapiens_hsa052160.45579470
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.44849750
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44471619
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44340703
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.43910181
120Insulin resistance_Homo sapiens_hsa049310.43648184
121Staphylococcus aureus infection_Homo sapiens_hsa051500.43523968
122Salmonella infection_Homo sapiens_hsa051320.43236168
123Asthma_Homo sapiens_hsa053100.41964364
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40311080
125ABC transporters_Homo sapiens_hsa020100.38737536
126Adherens junction_Homo sapiens_hsa045200.38454783
127Chronic myeloid leukemia_Homo sapiens_hsa052200.38003545
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37141274
129beta-Alanine metabolism_Homo sapiens_hsa004100.36916866
130Pathways in cancer_Homo sapiens_hsa052000.36787153
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36549882
132Autoimmune thyroid disease_Homo sapiens_hsa053200.34657362
133VEGF signaling pathway_Homo sapiens_hsa043700.34046346
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33669484
135Chemokine signaling pathway_Homo sapiens_hsa040620.33359150
136Retinol metabolism_Homo sapiens_hsa008300.32823565
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32427596
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31146568

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »