PRH1-PRR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.75506589
2regulation of cilium movement (GO:0003352)5.09501122
3nucleobase catabolic process (GO:0046113)4.72894700
4protein polyglutamylation (GO:0018095)4.61388748
5positive regulation of mitochondrial fission (GO:0090141)4.47347175
6retinal cone cell development (GO:0046549)4.01137101
7cellular ketone body metabolic process (GO:0046950)3.98916780
8positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.85762266
9mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.85762266
10coenzyme catabolic process (GO:0009109)3.83863923
11mannosylation (GO:0097502)3.72325993
12platelet dense granule organization (GO:0060155)3.68489066
13cellular response to leptin stimulus (GO:0044320)3.66642647
14ketone body metabolic process (GO:1902224)3.54032119
15C-terminal protein lipidation (GO:0006501)3.47425966
16single strand break repair (GO:0000012)3.46872867
17nucleotide transmembrane transport (GO:1901679)3.44849684
18cullin deneddylation (GO:0010388)3.41398005
19branched-chain amino acid catabolic process (GO:0009083)3.40496013
20iron-sulfur cluster assembly (GO:0016226)3.39549441
21metallo-sulfur cluster assembly (GO:0031163)3.39549441
22nonmotile primary cilium assembly (GO:0035058)3.36515222
23peptidyl-histidine modification (GO:0018202)3.29607045
24regulation of microtubule-based movement (GO:0060632)3.17000333
25DNA damage response, detection of DNA damage (GO:0042769)3.15872772
26axoneme assembly (GO:0035082)3.15106125
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13942139
28response to pheromone (GO:0019236)3.12382849
29preassembly of GPI anchor in ER membrane (GO:0016254)3.10891192
30brain morphogenesis (GO:0048854)3.10174027
31anterograde synaptic vesicle transport (GO:0048490)3.08409724
32protein complex biogenesis (GO:0070271)3.06122914
33artery smooth muscle contraction (GO:0014824)3.01407795
34respiratory chain complex IV assembly (GO:0008535)2.99858569
35C-terminal protein amino acid modification (GO:0018410)2.98992253
36peptidyl-cysteine modification (GO:0018198)2.98672507
37GPI anchor metabolic process (GO:0006505)2.94601525
38regulation of mitochondrial fission (GO:0090140)2.93713698
39mitochondrial respiratory chain complex assembly (GO:0033108)2.93182616
40protein deneddylation (GO:0000338)2.92785794
41DNA double-strand break processing (GO:0000729)2.92558077
42DNA integration (GO:0015074)2.92059732
43vascular smooth muscle contraction (GO:0014829)2.88264594
44cell wall macromolecule catabolic process (GO:0016998)2.88085188
45mitochondrial fission (GO:0000266)2.85392592
46glycerophospholipid catabolic process (GO:0046475)2.83567038
47response to leptin (GO:0044321)2.82184289
48cholesterol biosynthetic process (GO:0006695)2.81790080
49retinal ganglion cell axon guidance (GO:0031290)2.81426425
50intraciliary transport (GO:0042073)2.81158675
51adenosine metabolic process (GO:0046085)2.80679532
52short-term memory (GO:0007614)2.75992792
53regulation of mitochondrial translation (GO:0070129)2.73594233
54microtubule severing (GO:0051013)2.73270578
55positive regulation of amino acid transport (GO:0051957)2.70911400
56sperm motility (GO:0030317)2.70879833
57cytochrome complex assembly (GO:0017004)2.70210214
58cofactor catabolic process (GO:0051187)2.70099310
59regulation of feeding behavior (GO:0060259)2.68373603
60GPI anchor biosynthetic process (GO:0006506)2.68099540
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.67447164
62NADH dehydrogenase complex assembly (GO:0010257)2.67447164
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67447164
64microtubule depolymerization (GO:0007019)2.67102653
65presynaptic membrane assembly (GO:0097105)2.65611138
66melanosome transport (GO:0032402)2.64978441
67ubiquinone metabolic process (GO:0006743)2.64391101
68photoreceptor cell development (GO:0042461)2.64042406
69protoporphyrinogen IX biosynthetic process (GO:0006782)2.62819765
70dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62553745
71acrosome reaction (GO:0007340)2.62518228
72eye photoreceptor cell development (GO:0042462)2.61251918
73establishment of melanosome localization (GO:0032401)2.60947023
74cilium morphogenesis (GO:0060271)2.60613317
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60261096
76regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.60061417
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59382678
78ubiquinone biosynthetic process (GO:0006744)2.58413725
79regulation of glutamate secretion (GO:0014048)2.58218428
80negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57639713
81negative regulation of amino acid transport (GO:0051956)2.56714064
82tonic smooth muscle contraction (GO:0014820)2.55957230
83regulation of memory T cell differentiation (GO:0043380)2.53792564
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53368455
85glial cell proliferation (GO:0014009)2.53319909
86cell wall macromolecule metabolic process (GO:0044036)2.52307749
87pigment granule transport (GO:0051904)2.52037510
88postsynaptic membrane organization (GO:0001941)2.51825702
89photoreceptor cell maintenance (GO:0045494)2.51179152
90sterol biosynthetic process (GO:0016126)2.49908780
91histone H2A acetylation (GO:0043968)2.49829521
92establishment of pigment granule localization (GO:0051905)2.48744020
93cilium assembly (GO:0042384)2.48481356
94protein neddylation (GO:0045116)2.47457092
95presynaptic membrane organization (GO:0097090)2.47354915
96dendritic spine morphogenesis (GO:0060997)2.47104313
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46095667
98cilium organization (GO:0044782)2.45586854
99positive regulation of TOR signaling (GO:0032008)2.45203567
100sequestering of actin monomers (GO:0042989)2.45136076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.66987729
2ZNF274_21170338_ChIP-Seq_K562_Hela3.56058210
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24024153
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13110126
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.11950718
6GBX2_23144817_ChIP-Seq_PC3_Human3.09200126
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91582179
8TAF15_26573619_Chip-Seq_HEK293_Human2.75812281
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45709808
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42956289
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42489801
12FUS_26573619_Chip-Seq_HEK293_Human2.27020069
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24605979
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10662646
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10458676
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.08064328
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03395695
18EWS_26573619_Chip-Seq_HEK293_Human1.98707323
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97823419
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.96955498
21P300_19829295_ChIP-Seq_ESCs_Human1.92873514
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.86941522
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81890566
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80642233
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77812966
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76443951
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.72110639
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71796821
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67576669
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66689714
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64846280
32SMAD4_21799915_ChIP-Seq_A2780_Human1.61099803
33ELK1_19687146_ChIP-ChIP_HELA_Human1.59029468
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56950351
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55921104
36VDR_23849224_ChIP-Seq_CD4+_Human1.50772603
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50286608
38VDR_22108803_ChIP-Seq_LS180_Human1.48878880
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47963126
40CBP_20019798_ChIP-Seq_JUKART_Human1.47963126
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45972031
42IRF1_19129219_ChIP-ChIP_H3396_Human1.42598286
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41731897
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39978481
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37111086
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35455424
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34314113
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.32392039
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31867571
50EZH2_22144423_ChIP-Seq_EOC_Human1.30521210
51RNF2_27304074_Chip-Seq_NSC_Mouse1.29787486
52STAT3_23295773_ChIP-Seq_U87_Human1.29029040
53TP53_22573176_ChIP-Seq_HFKS_Human1.28759406
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28624018
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26905037
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24073379
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22967069
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22696099
59DCP1A_22483619_ChIP-Seq_HELA_Human1.21506905
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20808092
61TCF4_23295773_ChIP-Seq_U87_Human1.20752594
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.19416693
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19163118
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18364354
65ER_23166858_ChIP-Seq_MCF-7_Human1.17511977
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.16445665
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.15096182
68AR_25329375_ChIP-Seq_VCAP_Human1.12405955
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.12119520
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11235308
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09068927
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.08571397
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06812853
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.06036103
75RUNX2_22187159_ChIP-Seq_PCA_Human1.05395195
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04444597
77SOX9_26525672_Chip-Seq_HEART_Mouse1.03226245
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.02656340
79BCAT_22108803_ChIP-Seq_LS180_Human1.02086578
80MYC_18940864_ChIP-ChIP_HL60_Human1.01921020
81GABP_19822575_ChIP-Seq_HepG2_Human1.01553568
82AR_20517297_ChIP-Seq_VCAP_Human1.01120257
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99533239
84REST_21632747_ChIP-Seq_MESCs_Mouse0.98015874
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.97734736
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96211540
87SMAD3_21741376_ChIP-Seq_EPCs_Human0.96161120
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95837180
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95170764
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94266791
91NANOG_19829295_ChIP-Seq_ESCs_Human0.94043460
92SOX2_19829295_ChIP-Seq_ESCs_Human0.94043460
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93766570
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93623765
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93022596
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92783959
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92702021
98JUN_21703547_ChIP-Seq_K562_Human0.92194523
99P53_22387025_ChIP-Seq_ESCs_Mouse0.90121721
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.89841196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.99821115
2MP0003880_abnormal_central_pattern3.40644816
3MP0001984_abnormal_olfaction3.22254823
4MP0000372_irregular_coat_pigmentation3.19884719
5MP0002102_abnormal_ear_morphology3.17792373
6MP0003011_delayed_dark_adaptation2.92738577
7MP0008789_abnormal_olfactory_epithelium2.64795869
8MP0004147_increased_porphyrin_level2.62719973
9MP0005670_abnormal_white_adipose2.57533166
10MP0006276_abnormal_autonomic_nervous2.52478280
11MP0002234_abnormal_pharynx_morphology2.34875192
12MP0005645_abnormal_hypothalamus_physiol2.27117717
13MP0002822_catalepsy2.20462659
14MP0005394_taste/olfaction_phenotype2.18051823
15MP0005499_abnormal_olfactory_system2.18051823
16MP0005253_abnormal_eye_physiology2.16332620
17MP0001968_abnormal_touch/_nociception2.14795514
18MP0006292_abnormal_olfactory_placode2.00593492
19MP0006072_abnormal_retinal_apoptosis1.96258136
20MP0003122_maternal_imprinting1.90534813
21MP0003656_abnormal_erythrocyte_physiolo1.87584944
22MP0002736_abnormal_nociception_after1.84502254
23MP0005551_abnormal_eye_electrophysiolog1.83680969
24MP0005410_abnormal_fertilization1.83091259
25MP0009046_muscle_twitch1.82106730
26MP0002638_abnormal_pupillary_reflex1.76781691
27MP0004270_analgesia1.74255215
28MP0001764_abnormal_homeostasis1.66326384
29MP0002909_abnormal_adrenal_gland1.66108485
30MP0006035_abnormal_mitochondrial_morpho1.57352692
31MP0008872_abnormal_physiological_respon1.54283067
32MP0002163_abnormal_gland_morphology1.47867946
33MP0006054_spinal_hemorrhage1.41561949
34MP0001270_distended_abdomen1.38721162
35MP0002272_abnormal_nervous_system1.38046185
36MP0002751_abnormal_autonomic_nervous1.31858650
37MP0005386_behavior/neurological_phenoty1.31561201
38MP0004924_abnormal_behavior1.31561201
39MP0009697_abnormal_copulation1.30906395
40MP0005379_endocrine/exocrine_gland_phen1.29475866
41MP0005367_renal/urinary_system_phenotyp1.29355911
42MP0000516_abnormal_urinary_system1.29355911
43MP0008058_abnormal_DNA_repair1.28937661
44MP0000778_abnormal_nervous_system1.24261686
45MP0001486_abnormal_startle_reflex1.24084861
46MP0010386_abnormal_urinary_bladder1.19607800
47MP0002557_abnormal_social/conspecific_i1.13091898
48MP0002332_abnormal_exercise_endurance1.12262684
49MP0006036_abnormal_mitochondrial_physio1.11322923
50MP0001661_extended_life_span1.09955202
51MP0003787_abnormal_imprinting1.09885815
52MP0002733_abnormal_thermal_nociception1.09265227
53MP0002067_abnormal_sensory_capabilities1.07909914
54MP0000631_abnormal_neuroendocrine_gland1.06429754
55MP0002160_abnormal_reproductive_system1.03583865
56MP0000427_abnormal_hair_cycle1.03315380
57MP0008875_abnormal_xenobiotic_pharmacok1.02596844
58MP0004742_abnormal_vestibular_system1.00530668
59MP0004142_abnormal_muscle_tone1.00484356
60MP0005332_abnormal_amino_acid0.99638529
61MP0000358_abnormal_cell_content/0.98440921
62MP0002184_abnormal_innervation0.97976216
63MP0005646_abnormal_pituitary_gland0.97611028
64MP0005391_vision/eye_phenotype0.96740721
65MP0009745_abnormal_behavioral_response0.96565475
66MP0002734_abnormal_mechanical_nocicepti0.94224977
67MP0001970_abnormal_pain_threshold0.92348800
68MP0005389_reproductive_system_phenotype0.91987574
69MP0002572_abnormal_emotion/affect_behav0.91664915
70MP0000013_abnormal_adipose_tissue0.90279062
71MP0002752_abnormal_somatic_nervous0.89996679
72MP0001905_abnormal_dopamine_level0.89951393
73MP0002882_abnormal_neuron_morphology0.86626388
74MP0003698_abnormal_male_reproductive0.84793861
75MP0005266_abnormal_metabolism0.83881763
76MP0005636_abnormal_mineral_homeostasis0.83865207
77MP0003718_maternal_effect0.82923630
78MP0004811_abnormal_neuron_physiology0.82539360
79MP0002063_abnormal_learning/memory/cond0.81451081
80MP0005195_abnormal_posterior_eye0.81296039
81MP0003121_genomic_imprinting0.79439639
82MP0003635_abnormal_synaptic_transmissio0.79358466
83MP0010329_abnormal_lipoprotein_level0.79330648
84MP0003221_abnormal_cardiomyocyte_apopto0.78453627
85MP0002233_abnormal_nose_morphology0.78415100
86MP0008877_abnormal_DNA_methylation0.76672492
87MP0005220_abnormal_exocrine_pancreas0.76218090
88MP0002229_neurodegeneration0.76138520
89MP0002938_white_spotting0.74948377
90MP0000647_abnormal_sebaceous_gland0.74476217
91MP0003137_abnormal_impulse_conducting0.74347974
92MP0003186_abnormal_redox_activity0.74094156
93MP0000955_abnormal_spinal_cord0.74082719
94MP0005083_abnormal_biliary_tract0.73816478
95MP0002653_abnormal_ependyma_morphology0.72303532
96MP0002693_abnormal_pancreas_physiology0.71764117
97MP0005084_abnormal_gallbladder_morpholo0.71746298
98MP0000639_abnormal_adrenal_gland0.71338556
99MP0005248_abnormal_Harderian_gland0.70887958
100MP0000049_abnormal_middle_ear0.70287137

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.03926575
2Gait imbalance (HP:0002141)3.76670246
3Congenital primary aphakia (HP:0007707)3.73411639
4Acute necrotizing encephalopathy (HP:0006965)3.44417225
5Acute encephalopathy (HP:0006846)3.42831306
6Nephrogenic diabetes insipidus (HP:0009806)3.31272318
73-Methylglutaconic aciduria (HP:0003535)3.31215996
8Polyphagia (HP:0002591)3.16934547
9Abnormal mitochondria in muscle tissue (HP:0008316)3.12022810
10Progressive macrocephaly (HP:0004481)3.10790302
11Molar tooth sign on MRI (HP:0002419)2.94311794
12Abnormality of midbrain morphology (HP:0002418)2.94311794
13Tubulointerstitial nephritis (HP:0001970)2.89733299
14Abnormal gallbladder physiology (HP:0012438)2.80881530
15Cholecystitis (HP:0001082)2.80881530
16Pancreatic fibrosis (HP:0100732)2.76088469
17Pancreatic cysts (HP:0001737)2.74771514
18True hermaphroditism (HP:0010459)2.71700673
19Intestinal atresia (HP:0011100)2.68785879
20Poor coordination (HP:0002370)2.68453009
21Genital tract atresia (HP:0001827)2.63690590
22Mitochondrial inheritance (HP:0001427)2.63571740
23Postaxial foot polydactyly (HP:0001830)2.58114395
24Hemiparesis (HP:0001269)2.57047070
25Broad foot (HP:0001769)2.56520691
26Vaginal atresia (HP:0000148)2.55755265
27Abnormality of alanine metabolism (HP:0010916)2.47478748
28Hyperalaninemia (HP:0003348)2.47478748
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47478748
30Increased CSF lactate (HP:0002490)2.46249862
31Hepatocellular necrosis (HP:0001404)2.45633157
32Cerebral edema (HP:0002181)2.41786649
33Febrile seizures (HP:0002373)2.40580982
34Renal cortical cysts (HP:0000803)2.39489164
35Attenuation of retinal blood vessels (HP:0007843)2.38871405
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.38770298
37Retinal dysplasia (HP:0007973)2.35947316
38Short tibia (HP:0005736)2.33432915
39Exercise-induced muscle cramps (HP:0003710)2.31316459
40Pancreatic islet-cell hyperplasia (HP:0004510)2.30352050
41Chronic hepatic failure (HP:0100626)2.30200640
42Upper limb muscle weakness (HP:0003484)2.29500091
43Cortical dysplasia (HP:0002539)2.28845789
44Atonic seizures (HP:0010819)2.28049530
45Optic disc pallor (HP:0000543)2.26749065
46Postaxial hand polydactyly (HP:0001162)2.26523038
47Poor suck (HP:0002033)2.26035490
48Abnormality of the metopic suture (HP:0005556)2.25996449
49Abnormal protein N-linked glycosylation (HP:0012347)2.24074221
50Abnormal protein glycosylation (HP:0012346)2.24074221
51Abnormal glycosylation (HP:0012345)2.24074221
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24074221
53Bifid tongue (HP:0010297)2.23979110
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20236067
55Chorioretinal atrophy (HP:0000533)2.17448345
56Abnormality of the renal cortex (HP:0011035)2.15706274
57Hepatic necrosis (HP:0002605)2.15198998
58Specific learning disability (HP:0001328)2.15194253
59Epidermoid cyst (HP:0200040)2.14161232
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.13782503
61Delayed CNS myelination (HP:0002188)2.12127858
62Bony spicule pigmentary retinopathy (HP:0007737)2.11874304
63Abnormality of the labia minora (HP:0012880)2.05499867
64Thyroid-stimulating hormone excess (HP:0002925)2.04471498
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02667738
66Hypoplasia of the brainstem (HP:0002365)2.02667738
67Hyperglycinemia (HP:0002154)2.00569502
68Gaze-evoked nystagmus (HP:0000640)1.99390723
69Occipital encephalocele (HP:0002085)1.99010344
70EEG with generalized epileptiform discharges (HP:0011198)1.94721634
71Generalized myoclonic seizures (HP:0002123)1.93728230
72Prominent metopic ridge (HP:0005487)1.92743098
73Abnormality of the heme biosynthetic pathway (HP:0010472)1.91493683
74Abnormality of dental color (HP:0011073)1.91182963
75Abolished electroretinogram (ERG) (HP:0000550)1.91054290
76Hyperinsulinemic hypoglycemia (HP:0000825)1.91013944
77Nephronophthisis (HP:0000090)1.90974514
78Aplasia/Hypoplasia of the lens (HP:0008063)1.89351324
79Hypsarrhythmia (HP:0002521)1.88711648
80Lissencephaly (HP:0001339)1.88137678
81Ketoacidosis (HP:0001993)1.87549011
82Lactic acidosis (HP:0003128)1.87546957
83Polymicrogyria (HP:0002126)1.87101414
84Decreased testicular size (HP:0008734)1.85956084
85Preaxial hand polydactyly (HP:0001177)1.82622560
86Inability to walk (HP:0002540)1.82610962
87Increased serum lactate (HP:0002151)1.81719923
88Amblyopia (HP:0000646)1.80173092
89Epileptiform EEG discharges (HP:0011182)1.79533929
90Respiratory failure (HP:0002878)1.78470455
91Pachygyria (HP:0001302)1.77417564
92Ketosis (HP:0001946)1.77375475
93Drooling (HP:0002307)1.76599938
94Congenital hepatic fibrosis (HP:0002612)1.76359469
95Aplasia/hypoplasia of the uterus (HP:0008684)1.75870748
96Narrow forehead (HP:0000341)1.74645491
97Albinism (HP:0001022)1.73870199
98Abnormality of glycolysis (HP:0004366)1.72459886
99Lethargy (HP:0001254)1.71714264
100Tubulointerstitial abnormality (HP:0001969)1.71237014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK2.23379595
2MAP4K214.3930883
3NUAK11.87415437
4BCR1.71000160
5TRIM281.59849961
6FRK1.59791142
7CSNK1G31.45241994
8CASK1.36184837
9CSNK1A1L1.31601087
10CSNK1G21.24997254
11MARK11.23878469
12ERBB31.20920662
13MAP3K41.20883673
14EPHA41.20644583
15BMPR1B1.16653948
16MAPK131.15712524
17CSNK1G11.08480078
18DYRK21.05830265
19PIM21.04026071
20VRK21.02404926
21PLK21.01217386
22GRK10.98667248
23ADRBK20.95619210
24VRK10.94627374
25PAK30.92197554
26AKT30.90797593
27INSRR0.90338170
28SRPK10.90028840
29DAPK20.84343489
30MAP2K70.83392672
31WNK30.82667169
32ZAK0.82236035
33DAPK10.76607900
34DYRK30.73507828
35TESK10.70135313
36PRKCE0.67462950
37PRKD30.66668074
38PLK40.65204799
39RAF10.65074168
40TNIK0.63566320
41EPHA30.62660583
42BRSK20.56677649
43GRK50.52820411
44RPS6KA40.50292893
45WNK40.48787814
46LIMK10.48053780
47EIF2AK10.47397489
48CCNB10.44824106
49FER0.44734426
50STK390.44726037
51MST1R0.44217147
52CDK80.40651772
53DYRK1A0.39932902
54LATS10.38910230
55CAMKK20.35045993
56LMTK20.34987087
57EPHB20.34600909
58PAK60.33401704
59MAP3K120.33369064
60KSR10.33121069
61EIF2AK30.32991194
62PLK30.32570293
63CDK30.30929138
64MST40.30297530
65CSNK1A10.29180042
66MKNK10.29037356
67CDK90.27918099
68BMX0.27673421
69TLK10.27386183
70PKN10.26973488
71WEE10.25859949
72FLT30.25342250
73ADRBK10.25304424
74PRKAA10.25014124
75PINK10.23982061
76PRKCG0.23859594
77STK38L0.23706750
78PHKG20.23314404
79PHKG10.23314404
80OXSR10.23082284
81CAMK2B0.22110275
82CAMK2D0.20668834
83RPS6KA50.20633191
84MUSK0.20470471
85CSNK1D0.20146813
86NTRK20.19719170
87ATM0.19362817
88MYLK0.18915796
89CAMK2A0.18896050
90MAPKAPK50.18730317
91ROCK10.18019212
92SIK30.17894346
93MATK0.17815690
94CDK50.17263347
95DYRK1B0.16741602
96PLK10.16386965
97PRKACA0.15556401
98PRKACB0.15034440
99KDR0.14511743
100PRKCZ0.14491681

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.09884844
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.18494695
3Butanoate metabolism_Homo sapiens_hsa006502.40428441
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.38914159
5Steroid biosynthesis_Homo sapiens_hsa001002.37498634
6Protein export_Homo sapiens_hsa030602.34275614
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07265083
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05668610
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90597401
10Propanoate metabolism_Homo sapiens_hsa006401.88606158
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84448904
12Fatty acid elongation_Homo sapiens_hsa000621.84018565
13Oxidative phosphorylation_Homo sapiens_hsa001901.80515730
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68436218
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67318477
16Peroxisome_Homo sapiens_hsa041461.62181242
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60534314
18RNA polymerase_Homo sapiens_hsa030201.56586721
19Circadian rhythm_Homo sapiens_hsa047101.54221170
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51016333
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50290350
22Sulfur metabolism_Homo sapiens_hsa009201.45530953
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42654803
24Regulation of autophagy_Homo sapiens_hsa041401.41505023
25Collecting duct acid secretion_Homo sapiens_hsa049661.35318751
26Parkinsons disease_Homo sapiens_hsa050121.32858528
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.30758022
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29922262
29Phototransduction_Homo sapiens_hsa047441.25898453
30One carbon pool by folate_Homo sapiens_hsa006701.25270323
31Nitrogen metabolism_Homo sapiens_hsa009101.23164465
32Selenocompound metabolism_Homo sapiens_hsa004501.20773516
33GABAergic synapse_Homo sapiens_hsa047271.20252468
34N-Glycan biosynthesis_Homo sapiens_hsa005101.18760162
35Fatty acid metabolism_Homo sapiens_hsa012121.17779129
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16486372
37Olfactory transduction_Homo sapiens_hsa047401.15224597
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14995526
39Salivary secretion_Homo sapiens_hsa049701.11709577
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10254314
41Biosynthesis of amino acids_Homo sapiens_hsa012301.09409309
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09330016
43Fructose and mannose metabolism_Homo sapiens_hsa000511.05658649
44beta-Alanine metabolism_Homo sapiens_hsa004101.04541222
45Arginine and proline metabolism_Homo sapiens_hsa003301.03382326
46Pyrimidine metabolism_Homo sapiens_hsa002401.02651796
47Sulfur relay system_Homo sapiens_hsa041221.02596993
48Folate biosynthesis_Homo sapiens_hsa007901.02247672
49Huntingtons disease_Homo sapiens_hsa050161.00046734
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98105354
51Non-homologous end-joining_Homo sapiens_hsa034500.95863195
52Fanconi anemia pathway_Homo sapiens_hsa034600.92559350
53Metabolic pathways_Homo sapiens_hsa011000.92006003
54Carbon metabolism_Homo sapiens_hsa012000.90299061
55Glycerolipid metabolism_Homo sapiens_hsa005610.88892071
56Glutathione metabolism_Homo sapiens_hsa004800.88700881
57Nicotine addiction_Homo sapiens_hsa050330.88304252
58Vibrio cholerae infection_Homo sapiens_hsa051100.87660105
59RNA degradation_Homo sapiens_hsa030180.87453298
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.83055496
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80688920
62Sphingolipid metabolism_Homo sapiens_hsa006000.79643038
63Morphine addiction_Homo sapiens_hsa050320.79563263
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77860745
65Purine metabolism_Homo sapiens_hsa002300.77611565
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76698087
67Alzheimers disease_Homo sapiens_hsa050100.74336528
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73121738
69Insulin secretion_Homo sapiens_hsa049110.71729252
70Tryptophan metabolism_Homo sapiens_hsa003800.71628942
71Chemical carcinogenesis_Homo sapiens_hsa052040.70495502
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.70057046
73Pyruvate metabolism_Homo sapiens_hsa006200.68703882
74Dopaminergic synapse_Homo sapiens_hsa047280.67415434
75Retinol metabolism_Homo sapiens_hsa008300.65164664
76Oocyte meiosis_Homo sapiens_hsa041140.64859462
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64238265
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63534028
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63431376
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62912052
81Proteasome_Homo sapiens_hsa030500.62806108
82Base excision repair_Homo sapiens_hsa034100.62240475
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60362630
84Pentose phosphate pathway_Homo sapiens_hsa000300.60302604
85Alcoholism_Homo sapiens_hsa050340.60009212
86Taste transduction_Homo sapiens_hsa047420.58068420
87ABC transporters_Homo sapiens_hsa020100.56111714
88Synaptic vesicle cycle_Homo sapiens_hsa047210.55186219
89Homologous recombination_Homo sapiens_hsa034400.52929612
90Glutamatergic synapse_Homo sapiens_hsa047240.52658850
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.52058012
92Basal transcription factors_Homo sapiens_hsa030220.51839695
93Cocaine addiction_Homo sapiens_hsa050300.48008708
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45351263
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43186225
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42758182
97Thyroid hormone synthesis_Homo sapiens_hsa049180.42167236
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.41348695
99Fatty acid degradation_Homo sapiens_hsa000710.39842558
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38056911

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »