PREX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)5.15365518
2amino acid import (GO:0043090)4.71412160
3endothelium development (GO:0003158)4.30918573
4blood vessel maturation (GO:0001955)4.08683267
5lymph vessel development (GO:0001945)3.73898448
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.71863880
7negative regulation of translation, ncRNA-mediated (GO:0040033)3.71863880
8regulation of translation, ncRNA-mediated (GO:0045974)3.71863880
9presynaptic membrane assembly (GO:0097105)3.67580964
10postsynaptic membrane organization (GO:0001941)3.60044206
11retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47699553
12regulation of posttranscriptional gene silencing (GO:0060147)3.45862802
13regulation of gene silencing by miRNA (GO:0060964)3.45862802
14regulation of gene silencing by RNA (GO:0060966)3.45862802
15neurotransmitter-gated ion channel clustering (GO:0072578)3.44807901
16C4-dicarboxylate transport (GO:0015740)3.44578275
17vascular endothelial growth factor signaling pathway (GO:0038084)3.43455969
18artery development (GO:0060840)3.42225528
19peripheral nervous system axon ensheathment (GO:0032292)3.33482717
20myelination in peripheral nervous system (GO:0022011)3.33482717
21lymphangiogenesis (GO:0001946)3.30681723
22surfactant homeostasis (GO:0043129)3.27985570
23locomotory exploration behavior (GO:0035641)3.25059723
24endothelial cell differentiation (GO:0045446)3.19162288
25atrial cardiac muscle cell action potential (GO:0086014)3.18360003
26embryonic foregut morphogenesis (GO:0048617)3.17267978
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17149930
28regulation of timing of cell differentiation (GO:0048505)3.17086094
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15506605
30lung lobe morphogenesis (GO:0060463)3.13702650
31protein heterotetramerization (GO:0051290)3.09543289
32negative regulation of protein localization to cell surface (GO:2000009)3.06394972
33regulation of development, heterochronic (GO:0040034)3.06321734
34presynaptic membrane organization (GO:0097090)3.06213684
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.04085483
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03665981
37glutamate receptor signaling pathway (GO:0007215)3.02536169
38neuronal action potential propagation (GO:0019227)2.98004661
39negative regulation of astrocyte differentiation (GO:0048712)2.96211350
40metanephric tubule development (GO:0072170)2.95012426
41metanephric nephron tubule development (GO:0072234)2.95012426
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92704346
43cardiac left ventricle morphogenesis (GO:0003214)2.91564534
44cranial nerve structural organization (GO:0021604)2.90770312
45chemical homeostasis within a tissue (GO:0048875)2.87295380
46glomerulus development (GO:0032835)2.87231604
47metanephric nephron epithelium development (GO:0072243)2.86377221
48regulation of endothelial cell differentiation (GO:0045601)2.84000142
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83917384
50ventricular trabecula myocardium morphogenesis (GO:0003222)2.81142454
51chondroitin sulfate catabolic process (GO:0030207)2.81121099
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80590220
53response to auditory stimulus (GO:0010996)2.80484358
54inner ear receptor stereocilium organization (GO:0060122)2.79539656
55cellular potassium ion homeostasis (GO:0030007)2.79119421
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77465018
57positive regulation of vasculogenesis (GO:2001214)2.76158004
58auditory behavior (GO:0031223)2.74104109
59metanephric epithelium development (GO:0072207)2.73696237
60heart valve formation (GO:0003188)2.73637146
61limb bud formation (GO:0060174)2.72275792
62Notch signaling involved in heart development (GO:0061314)2.71550645
63ovulation cycle (GO:0042698)2.69565856
64alanine transport (GO:0032328)2.68498418
65paraxial mesoderm development (GO:0048339)2.68400673
66negative regulation of Rho protein signal transduction (GO:0035024)2.66287457
67lateral sprouting from an epithelium (GO:0060601)2.65612779
68cell communication by electrical coupling (GO:0010644)2.65577327
69long-term memory (GO:0007616)2.65200402
70vocalization behavior (GO:0071625)2.64348949
71ganglion development (GO:0061548)2.63726434
72regulation of axon extension involved in axon guidance (GO:0048841)2.63615571
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62856286
74cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62673720
75gamma-aminobutyric acid transport (GO:0015812)2.61875417
76axon ensheathment in central nervous system (GO:0032291)2.61811237
77central nervous system myelination (GO:0022010)2.61811237
78regulation of pigment cell differentiation (GO:0050932)2.61394292
79synaptic transmission, glutamatergic (GO:0035249)2.59778496
80potassium ion import (GO:0010107)2.59277976
81otic vesicle formation (GO:0030916)2.58899091
82cellular response to nitric oxide (GO:0071732)2.58797047
83DNA double-strand break processing (GO:0000729)2.58795394
84neurotransmitter uptake (GO:0001504)2.58436507
85phenol-containing compound catabolic process (GO:0019336)2.58077953
86regulation of somitogenesis (GO:0014807)2.58031668
87hyperosmotic salinity response (GO:0042538)2.56882397
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.55313902
89dermatan sulfate metabolic process (GO:0030205)2.53971681
90cerebral cortex radially oriented cell migration (GO:0021799)2.53857391
91cochlea development (GO:0090102)2.53642243
92negative regulation of actin filament bundle assembly (GO:0032232)2.52465030
93regulation of vasculogenesis (GO:2001212)2.51686250
94pre-miRNA processing (GO:0031054)2.50650592
95regulation of phospholipid biosynthetic process (GO:0071071)2.50220655
96cellular response to cholesterol (GO:0071397)2.49509690
97anatomical structure arrangement (GO:0048532)2.49065139
98retina layer formation (GO:0010842)2.45906394
99establishment of monopolar cell polarity (GO:0061162)2.45493981
100establishment or maintenance of monopolar cell polarity (GO:0061339)2.45493981
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.45261003
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44435119
103dorsal/ventral axis specification (GO:0009950)2.44322772
104dermatan sulfate biosynthetic process (GO:0030208)2.44042653
105regulation of non-canonical Wnt signaling pathway (GO:2000050)2.43890748
106membrane assembly (GO:0071709)2.42334588
107regulation of respiratory system process (GO:0044065)2.42301972
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41413193
109regulation of axon guidance (GO:1902667)2.40617238
110axon extension involved in axon guidance (GO:0048846)2.40278349
111neuron projection extension involved in neuron projection guidance (GO:1902284)2.40278349
112limb development (GO:0060173)2.39585217
113appendage development (GO:0048736)2.39585217
114establishment of nucleus localization (GO:0040023)2.39072995
115nephron epithelium development (GO:0072009)2.38977521
116glomerular basement membrane development (GO:0032836)2.38171666
117establishment of apical/basal cell polarity (GO:0035089)2.36833251
118regulation of glutamate receptor signaling pathway (GO:1900449)2.36689281
119lung-associated mesenchyme development (GO:0060484)2.36014551
120chromatin remodeling at centromere (GO:0031055)2.35972890
121transmission of nerve impulse (GO:0019226)2.35591460
122positive regulation of protein kinase C signaling (GO:0090037)2.35556665
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35542820
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.35106786
125neuron cell-cell adhesion (GO:0007158)2.34971582
126regulation of cardiac muscle cell contraction (GO:0086004)2.34940130
127cAMP catabolic process (GO:0006198)2.34088477
128heart trabecula morphogenesis (GO:0061384)2.33729991
129positive regulation of endothelial cell differentiation (GO:0045603)2.31973489
130prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.31754782
131positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.31538007
132anterior/posterior axis specification, embryo (GO:0008595)2.31173123
133retinal ganglion cell axon guidance (GO:0031290)2.30152127
134inositol phosphate-mediated signaling (GO:0048016)2.29517144
135positive regulation of dendritic spine development (GO:0060999)2.29290605
136cGMP-mediated signaling (GO:0019934)2.29033307
137forebrain neuron differentiation (GO:0021879)2.28069900
138import into cell (GO:0098657)2.28046310
139pyrimidine nucleobase catabolic process (GO:0006208)2.27966725
140photoreceptor cell maintenance (GO:0045494)2.26141736
141regulation of cell fate specification (GO:0042659)2.26137206
142regulation of centriole replication (GO:0046599)2.23293325
143gap junction assembly (GO:0016264)2.23179392
144regulation of mesoderm development (GO:2000380)2.23144981
145retinal cone cell development (GO:0046549)2.22938182
146nucleus localization (GO:0051647)2.20189101
147negative regulation of DNA biosynthetic process (GO:2000279)2.20012975
148auditory receptor cell stereocilium organization (GO:0060088)2.19523481
149kidney morphogenesis (GO:0060993)2.19323065
150replication fork processing (GO:0031297)2.18704695
151organ growth (GO:0035265)2.15376415
152positive regulation of cardiac muscle cell differentiation (GO:2000727)2.15359845
153regulation of collateral sprouting (GO:0048670)2.15317824
154mechanosensory behavior (GO:0007638)2.14956761
155regulation of meiosis I (GO:0060631)2.13943166
156cellular response to sterol (GO:0036315)2.12965295
157vasculature development (GO:0001944)2.12742403
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.10624616
159inner ear receptor cell development (GO:0060119)2.10430852
160interkinetic nuclear migration (GO:0022027)2.09396093
161neuron recognition (GO:0008038)2.09220422
162somite development (GO:0061053)2.08977788
163histone exchange (GO:0043486)2.08562906
164cell surface receptor signaling pathway involved in heart development (GO:0061311)2.07104212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61922750
2GBX2_23144817_ChIP-Seq_PC3_Human3.36377124
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98560656
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.79240787
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78967706
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66982880
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66216603
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.65452413
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62691702
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49668637
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49668637
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45940063
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.39089533
14AR_21572438_ChIP-Seq_LNCaP_Human2.37271164
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36403481
16VDR_22108803_ChIP-Seq_LS180_Human2.29646367
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24077664
18IGF1R_20145208_ChIP-Seq_DFB_Human2.22761991
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.14527097
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12412884
21EWS_26573619_Chip-Seq_HEK293_Human2.06491664
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02875862
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02221036
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.98651054
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88936790
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87683555
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.84841649
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83288900
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80974876
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80614103
31* PIAS1_25552417_ChIP-Seq_VCAP_Human1.78560084
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.77844329
33DROSHA_22980978_ChIP-Seq_HELA_Human1.77430092
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73088180
35* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72198581
36ZNF274_21170338_ChIP-Seq_K562_Hela1.70281218
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69299502
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63824824
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54943749
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54045771
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54000829
42* P300_19829295_ChIP-Seq_ESCs_Human1.53160864
43TP53_16413492_ChIP-PET_HCT116_Human1.50291280
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.48568419
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45197473
46* FLI1_27457419_Chip-Seq_LIVER_Mouse1.44717305
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.41907332
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40488427
49TP53_18474530_ChIP-ChIP_U2OS_Human1.39201334
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39197845
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38704465
52* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37832517
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36963782
54STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34292175
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34079299
56* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32994084
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31473364
58TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31431269
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31277298
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30413649
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29889040
62* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29552605
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27972554
64* E2F1_18555785_Chip-Seq_ESCs_Mouse1.27475400
65* NANOG_18555785_Chip-Seq_ESCs_Mouse1.27274148
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26741552
67RNF2_27304074_Chip-Seq_NSC_Mouse1.25656703
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25510132
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25510132
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25407315
71CBP_20019798_ChIP-Seq_JUKART_Human1.25360340
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25360340
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25241318
74* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25190210
75* BCAT_22108803_ChIP-Seq_LS180_Human1.24840028
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.23704464
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23549017
78AHR_22903824_ChIP-Seq_MCF-7_Human1.22616030
79* TCF4_22108803_ChIP-Seq_LS180_Human1.22163383
80* AR_25329375_ChIP-Seq_VCAP_Human1.22116973
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21811891
82STAT3_23295773_ChIP-Seq_U87_Human1.21597673
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21429750
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.21329807
85FUS_26573619_Chip-Seq_HEK293_Human1.21203400
86RXR_22108803_ChIP-Seq_LS180_Human1.21112776
87* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20936853
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20802313
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19678735
90SOX9_26525672_Chip-Seq_HEART_Mouse1.19384849
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19050393
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18530363
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.18402576
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18282899
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18174089
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18060528
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17604459
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.16312836
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16309784
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.14177424
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.13919304
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.13378641
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12941837
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11821472
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11821472
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11821472
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11664013
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11041528
109* NFE2_27457419_Chip-Seq_LIVER_Mouse1.10903489
110* SMAD3_21741376_ChIP-Seq_ESCs_Human1.10428681
111REST_21632747_ChIP-Seq_MESCs_Mouse1.09212393
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.08526728
113* TCF4_23295773_ChIP-Seq_U87_Human1.08519317
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08064985
115* P53_22387025_ChIP-Seq_ESCs_Mouse1.08007346
116ER_23166858_ChIP-Seq_MCF-7_Human1.07598489
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07598117
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07051534
119* EZH2_27294783_Chip-Seq_NPCs_Mouse1.06941762
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.06734337
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06686165
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05310788
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04644471
124AR_19668381_ChIP-Seq_PC3_Human1.04450323
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.04398948
126* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04272056
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03934295
128* P300_18555785_Chip-Seq_ESCs_Mouse1.03773932
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03456771
130* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03022683
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02927825
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01658381
133* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01326926
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01142455
135TP53_20018659_ChIP-ChIP_R1E_Mouse1.01028199
136TAF15_26573619_Chip-Seq_HEK293_Human1.01005372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.91997185
2MP0003136_yellow_coat_color3.89696970
3MP0005409_darkened_coat_color2.99231588
4MP0001188_hyperpigmentation2.88682458
5MP0009379_abnormal_foot_pigmentation2.86703601
6MP0004272_abnormal_basement_membrane2.77534625
7MP0005171_absent_coat_pigmentation2.76198795
8MP0010368_abnormal_lymphatic_system2.75862705
9MP0001879_abnormal_lymphatic_vessel2.68713925
10MP0005670_abnormal_white_adipose2.33872169
11MP0004859_abnormal_synaptic_plasticity2.33803295
12MP0001293_anophthalmia2.22754553
13* MP0001486_abnormal_startle_reflex2.22570497
14MP0005167_abnormal_blood-brain_barrier2.10091141
15MP0006292_abnormal_olfactory_placode2.05122177
16MP0005084_abnormal_gallbladder_morpholo2.00618758
17MP0004885_abnormal_endolymph1.97769829
18MP0002638_abnormal_pupillary_reflex1.96818910
19MP0003880_abnormal_central_pattern1.90105011
20MP0002736_abnormal_nociception_after1.83391611
21MP0008877_abnormal_DNA_methylation1.83088589
22MP0009046_muscle_twitch1.76002051
23MP0008057_abnormal_DNA_replication1.72390091
24MP0003690_abnormal_glial_cell1.71805777
25MP0009384_cardiac_valve_regurgitation1.68164705
26MP0002249_abnormal_larynx_morphology1.66267546
27MP0004215_abnormal_myocardial_fiber1.62063257
28MP0000049_abnormal_middle_ear1.61681628
29MP0003878_abnormal_ear_physiology1.61198875
30MP0005377_hearing/vestibular/ear_phenot1.61198875
31MP0005595_abnormal_vascular_smooth1.59845826
32MP0003635_abnormal_synaptic_transmissio1.56591085
33MP0003119_abnormal_digestive_system1.56260601
34MP0009780_abnormal_chondrocyte_physiolo1.53588791
35MP0001984_abnormal_olfaction1.53289310
36MP0003890_abnormal_embryonic-extraembry1.51008298
37MP0004381_abnormal_hair_follicle1.47089298
38MP0009745_abnormal_behavioral_response1.46496621
39MP0003941_abnormal_skin_development1.42260537
40MP0006276_abnormal_autonomic_nervous1.41073883
41MP0003828_pulmonary_edema1.40600294
42MP0008569_lethality_at_weaning1.35421798
43MP0001440_abnormal_grooming_behavior1.34742503
44MP0005646_abnormal_pituitary_gland1.32813628
45MP0002572_abnormal_emotion/affect_behav1.30716581
46MP0001502_abnormal_circadian_rhythm1.29366183
47MP0003045_fibrosis1.25131160
48MP0002064_seizures1.24682832
49MP0001485_abnormal_pinna_reflex1.23717929
50MP0001299_abnormal_eye_distance/1.22993334
51MP0001501_abnormal_sleep_pattern1.22444819
52MP0003279_aneurysm1.21198398
53MP0004270_analgesia1.21004934
54MP0003724_increased_susceptibility_to1.20659243
55MP0009250_abnormal_appendicular_skeleto1.20365399
56MP0000778_abnormal_nervous_system1.19960277
57MP0002272_abnormal_nervous_system1.19819339
58MP0002233_abnormal_nose_morphology1.19796901
59MP0002102_abnormal_ear_morphology1.19491257
60MP0001177_atelectasis1.19382379
61MP0003950_abnormal_plasma_membrane1.19051593
62MP0002557_abnormal_social/conspecific_i1.18835188
63MP0000537_abnormal_urethra_morphology1.16744839
64MP0004133_heterotaxia1.16599417
65MP0005187_abnormal_penis_morphology1.15737647
66MP0003787_abnormal_imprinting1.15715874
67MP0000631_abnormal_neuroendocrine_gland1.14490285
68MP0002063_abnormal_learning/memory/cond1.13967504
69* MP0002067_abnormal_sensory_capabilities1.13787502
70MP0005257_abnormal_intraocular_pressure1.13224085
71MP0005423_abnormal_somatic_nervous1.12194728
72MP0000428_abnormal_craniofacial_morphol1.10521450
73MP0010030_abnormal_orbit_morphology1.10490653
74MP0001958_emphysema1.10186616
75MP0002697_abnormal_eye_size1.09593057
76MP0000026_abnormal_inner_ear1.09376856
77MP0004742_abnormal_vestibular_system1.09320669
78MP0002938_white_spotting1.08872759
79MP0003137_abnormal_impulse_conducting1.07714555
80MP0003122_maternal_imprinting1.06466643
81MP0006138_congestive_heart_failure1.05215036
82MP0003567_abnormal_fetal_cardiomyocyte1.05126254
83MP0003121_genomic_imprinting1.04525804
84MP0008058_abnormal_DNA_repair1.04519817
85MP0003935_abnormal_craniofacial_develop1.03574832
86MP0002009_preneoplasia1.03210178
87MP0004147_increased_porphyrin_level1.03097665
88MP0003937_abnormal_limbs/digits/tail_de1.02683781
89MP0003718_maternal_effect1.02206388
90MP0004145_abnormal_muscle_electrophysio1.01729751
91MP0004484_altered_response_of1.01715978
92MP0005165_increased_susceptibility_to1.01245298
93MP0002734_abnormal_mechanical_nocicepti1.01222984
94MP0009672_abnormal_birth_weight1.00997114
95MP0000569_abnormal_digit_pigmentation1.00186994
96MP0003938_abnormal_ear_development1.00180084
97MP0001968_abnormal_touch/_nociception0.98881171
98MP0005551_abnormal_eye_electrophysiolog0.97627268
99MP0002184_abnormal_innervation0.96705727
100MP0002735_abnormal_chemical_nociception0.95996157
101MP0005666_abnormal_adipose_tissue0.95990337
102MP0005391_vision/eye_phenotype0.95942331
103MP0005645_abnormal_hypothalamus_physiol0.95472144
104MP0006072_abnormal_retinal_apoptosis0.94017966
105MP0004858_abnormal_nervous_system0.94000069
106MP0009703_decreased_birth_body0.93752811
107MP0000955_abnormal_spinal_cord0.93147768
108MP0002138_abnormal_hepatobiliary_system0.93002086
109MP0004085_abnormal_heartbeat0.91542487
110MP0001286_abnormal_eye_development0.91464250
111MP0008995_early_reproductive_senescence0.90823121
112MP0003861_abnormal_nervous_system0.90202844
113MP0005253_abnormal_eye_physiology0.89167564
114MP0002332_abnormal_exercise_endurance0.88454925
115MP0001963_abnormal_hearing_physiology0.87723295
116MP0002084_abnormal_developmental_patter0.87146222
117* MP0002152_abnormal_brain_morphology0.86921356
118MP0004084_abnormal_cardiac_muscle0.86479833
119MP0003283_abnormal_digestive_organ0.86380213
120MP0002133_abnormal_respiratory_system0.85662373
121MP0005388_respiratory_system_phenotype0.85662373
122MP0009697_abnormal_copulation0.85572938
123MP0000751_myopathy0.83451305
124MP0000383_abnormal_hair_follicle0.82801904
125MP0002127_abnormal_cardiovascular_syste0.82334648
126MP0003633_abnormal_nervous_system0.82246596
127MP0003385_abnormal_body_wall0.82059730
128MP0000579_abnormal_nail_morphology0.81826322
129MP0000767_abnormal_smooth_muscle0.81661253
130MP0005620_abnormal_muscle_contractility0.81211127
131MP0002177_abnormal_outer_ear0.80807754
132MP0002733_abnormal_thermal_nociception0.78763620
133MP0002295_abnormal_pulmonary_circulatio0.78307830
134MP0002254_reproductive_system_inflammat0.77920348
135MP0005248_abnormal_Harderian_gland0.77433633
136MP0004924_abnormal_behavior0.77277639
137MP0005386_behavior/neurological_phenoty0.77277639
138MP0004142_abnormal_muscle_tone0.77224161
139MP0005195_abnormal_posterior_eye0.76446894
140MP0000372_irregular_coat_pigmentation0.75103349
141MP0001970_abnormal_pain_threshold0.75053774
142MP0002111_abnormal_tail_morphology0.74205307
143* MP0002882_abnormal_neuron_morphology0.72269490
144MP0000432_abnormal_head_morphology0.69414764
145MP0004130_abnormal_muscle_cell0.69403655
146MP0002752_abnormal_somatic_nervous0.68815963

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)4.66986380
2Aplasia involving bones of the extremities (HP:0009825)4.66986380
3Aplasia involving bones of the upper limbs (HP:0009823)4.66986380
4Abnormality of the axillary hair (HP:0100134)3.99965905
5Abnormality of secondary sexual hair (HP:0009888)3.99965905
6Intestinal atresia (HP:0011100)3.87005671
7Focal motor seizures (HP:0011153)3.82255589
8Colon cancer (HP:0003003)3.77657965
9Adactyly (HP:0009776)3.43496696
10Abnormality of the labia minora (HP:0012880)3.23296944
11Megalencephaly (HP:0001355)3.19733076
12Midline defect of the nose (HP:0004122)2.91934542
13Hypoplastic left heart (HP:0004383)2.87415086
14Hypoglycemic seizures (HP:0002173)2.82744338
15Action tremor (HP:0002345)2.79666626
16Aplasia cutis congenita (HP:0001057)2.79398499
17Gastrointestinal atresia (HP:0002589)2.75723154
18Pancreatic islet-cell hyperplasia (HP:0004510)2.73114412
19Synostosis involving the elbow (HP:0003938)2.71902733
20Humeroradial synostosis (HP:0003041)2.71902733
21Progressive cerebellar ataxia (HP:0002073)2.69409975
22Hemiparesis (HP:0001269)2.67039046
23Split foot (HP:0001839)2.61206245
24Onycholysis (HP:0001806)2.59058034
25Hemiplegia (HP:0002301)2.55892635
26Nasolacrimal duct obstruction (HP:0000579)2.52754817
27Chronic hepatic failure (HP:0100626)2.47122815
28Stenosis of the external auditory canal (HP:0000402)2.45780632
29Abnormality of the parietal bone (HP:0002696)2.45076867
30Hepatoblastoma (HP:0002884)2.42520753
31Pancreatic fibrosis (HP:0100732)2.40630898
32Hyperinsulinemic hypoglycemia (HP:0000825)2.39577997
33Alacrima (HP:0000522)2.38449313
34Tubulointerstitial nephritis (HP:0001970)2.36217783
35Enlarged penis (HP:0000040)2.35803535
36Febrile seizures (HP:0002373)2.35647884
37Abnormality of the nasolacrimal system (HP:0000614)2.33476436
38Abnormal lung lobation (HP:0002101)2.33293346
39Hypoplastic heart (HP:0001961)2.32029765
40Pancreatic cysts (HP:0001737)2.31750647
41Mixed hearing impairment (HP:0000410)2.30545738
42Short hallux (HP:0010109)2.28328709
43Absent hair (HP:0002298)2.27642662
44Broad metatarsal (HP:0001783)2.25619463
45Abnormality of the lacrimal duct (HP:0011481)2.25569776
46Atonic seizures (HP:0010819)2.24140677
47Renal hypoplasia (HP:0000089)2.24125760
48Abnormality of the middle phalanges of the toes (HP:0010183)2.21700416
49Skull defect (HP:0001362)2.20241324
50Broad-based gait (HP:0002136)2.19860827
51Cutaneous syndactyly (HP:0012725)2.18265114
52Portal hypertension (HP:0001409)2.17753075
53Bronchomalacia (HP:0002780)2.17583585
54Abnormality of the dental pulp (HP:0006479)2.16889006
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16651655
56Short 4th metacarpal (HP:0010044)2.16651655
57Neoplasm of the oral cavity (HP:0100649)2.16460436
58Optic nerve hypoplasia (HP:0000609)2.15028232
59Pulmonary artery stenosis (HP:0004415)2.14611758
60Cutaneous finger syndactyly (HP:0010554)2.14514207
61Biliary tract neoplasm (HP:0100574)2.13835316
62Thickened helices (HP:0000391)2.13601742
63Partial duplication of thumb phalanx (HP:0009944)2.10966518
64Abnormality of incisor morphology (HP:0011063)2.07787356
65Hyperventilation (HP:0002883)2.07535156
66Dysdiadochokinesis (HP:0002075)2.07397091
67Nephronophthisis (HP:0000090)2.06867224
68Morphological abnormality of the middle ear (HP:0008609)2.06785413
69Fibular aplasia (HP:0002990)2.06431955
70True hermaphroditism (HP:0010459)2.06162736
71Preaxial foot polydactyly (HP:0001841)2.05952795
72Partial duplication of the phalanx of hand (HP:0009999)2.05736822
73Decreased lacrimation (HP:0000633)2.05595148
74Obstructive sleep apnea (HP:0002870)2.04999695
75Meckel diverticulum (HP:0002245)2.02626066
76Abnormality of the renal medulla (HP:0100957)2.01191812
77Porencephaly (HP:0002132)2.00426299
78Abnormality of the hepatic vasculature (HP:0006707)1.99453070
79Long nose (HP:0003189)1.99043732
80Glioma (HP:0009733)1.98896934
81Gaze-evoked nystagmus (HP:0000640)1.98895049
82Abnormality of homocysteine metabolism (HP:0010919)1.98597462
83Homocystinuria (HP:0002156)1.98597462
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97665798
85Conical tooth (HP:0000698)1.97381249
86Confusion (HP:0001289)1.96387452
87Mesangial abnormality (HP:0001966)1.95542144
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95533744
89Hypoglycemic coma (HP:0001325)1.94784369
90Abnormality of the ileum (HP:0001549)1.94774787
91Hypoplasia of the iris (HP:0007676)1.93284383
92Congenital, generalized hypertrichosis (HP:0004540)1.91137419
93Bradycardia (HP:0001662)1.90967980
94Aplasia/Hypoplasia of the hallux (HP:0008362)1.90371482
95Rhabdomyosarcoma (HP:0002859)1.90270930
96Astrocytoma (HP:0009592)1.89957795
97Abnormality of the astrocytes (HP:0100707)1.89957795
98Renal dysplasia (HP:0000110)1.89411902
99Focal seizures (HP:0007359)1.88154930
100Absent hand (HP:0004050)1.87350897
101Hypoplasia of the ulna (HP:0003022)1.86801390
102Neoplasm of the small intestine (HP:0100833)1.86555135
103Ependymoma (HP:0002888)1.86527384
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.85886265
105Scanning speech (HP:0002168)1.85077390
106Abnormality of molar morphology (HP:0011070)1.84822679
107Abnormality of molar (HP:0011077)1.84822679
108Concave nail (HP:0001598)1.83979393
109Dialeptic seizures (HP:0011146)1.83817099
110Anophthalmia (HP:0000528)1.83653614
111Genital tract atresia (HP:0001827)1.82973619
112Coronal craniosynostosis (HP:0004440)1.82968408
113Supernumerary ribs (HP:0005815)1.82374947
114Molar tooth sign on MRI (HP:0002419)1.81487791
115Abnormality of midbrain morphology (HP:0002418)1.81487791
116Vitreoretinal degeneration (HP:0000655)1.80439131
117Septo-optic dysplasia (HP:0100842)1.79484629
118Supernumerary bones of the axial skeleton (HP:0009144)1.79308783
119Maternal diabetes (HP:0009800)1.79211878
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.78604966
121Agnosia (HP:0010524)1.78135054
122Supernumerary spleens (HP:0009799)1.77799193
123Abnormality of permanent molar morphology (HP:0011071)1.76994902
124Abnormality of the dental root (HP:0006486)1.76994902
125Taurodontia (HP:0000679)1.76994902
126Genetic anticipation (HP:0003743)1.76950851
127Abolished electroretinogram (ERG) (HP:0000550)1.76867355
128Broad hallux (HP:0010055)1.75738977
129Vaginal atresia (HP:0000148)1.75075430
130Esophageal atresia (HP:0002032)1.74882295
131Abnormality of the ischium (HP:0003174)1.74791466
132Epileptic encephalopathy (HP:0200134)1.74769146
133Hyperglycinemia (HP:0002154)1.74628947
134Scotoma (HP:0000575)1.73284352
135Absent toe (HP:0010760)1.72777545
136Abnormality of the 4th metacarpal (HP:0010012)1.72070446
137Drooling (HP:0002307)1.72055721
138Myotonia (HP:0002486)1.71230991
139Bifid tongue (HP:0010297)1.70248003
140Trigonocephaly (HP:0000243)1.70223696
141Myokymia (HP:0002411)1.70048175
142Cupped ear (HP:0000378)1.69964741
143Clitoromegaly (HP:0000057)1.68945109
144Tracheomalacia (HP:0002779)1.67556887
145Hypoplastic nipples (HP:0002557)1.67535518
146Congenital hepatic fibrosis (HP:0002612)1.66594707
147Aplasia/Hypoplasia of the ulna (HP:0006495)1.66177695
148Oligodactyly (hands) (HP:0001180)1.66083745
149Occipital encephalocele (HP:0002085)1.65846572
150Medulloblastoma (HP:0002885)1.65144248
151Atrial fibrillation (HP:0005110)1.64807335
152Abnormality of binocular vision (HP:0011514)1.64202864
153Diplopia (HP:0000651)1.64202864
154Protruding tongue (HP:0010808)1.63931504
155Nephroblastoma (Wilms tumor) (HP:0002667)1.63787260
156Thyroid-stimulating hormone excess (HP:0002925)1.63421504
157Aqueductal stenosis (HP:0002410)1.62197178
158Volvulus (HP:0002580)1.61250246
159Bile duct proliferation (HP:0001408)1.61122155
160Abnormal biliary tract physiology (HP:0012439)1.61122155
161Preaxial hand polydactyly (HP:0001177)1.60567692
162Prominent supraorbital ridges (HP:0000336)1.60543153
163Absent eyebrow (HP:0002223)1.60344620
164Bilateral microphthalmos (HP:0007633)1.60344536
165Limited hip movement (HP:0008800)1.60220098
166Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60171231
167Stomach cancer (HP:0012126)1.60135548
168Laryngomalacia (HP:0001601)1.59104802
169Embryonal renal neoplasm (HP:0011794)1.57792973
170Hydroureter (HP:0000072)1.56605916
171Short tibia (HP:0005736)1.56275397
1722-3 toe syndactyly (HP:0004691)1.55125287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.91315252
2TNIK4.72742734
3CASK3.89093604
4MKNK23.54370040
5MUSK2.91256668
6EPHA42.74201421
7TLK12.41455478
8INSRR2.34660922
9PHKG12.31634903
10PHKG22.31634903
11KDR2.27368105
12FRK2.18522480
13WNK32.06601137
14NTRK22.06177781
15PRPF4B1.89725687
16PNCK1.87898981
17NTRK31.73679260
18TAF11.71385436
19PRKD21.60773525
20PRKD31.58627260
21SGK21.53110854
22LMTK21.51817725
23MKNK11.46998743
24MAP3K61.45934336
25NUAK11.43564512
26CDC71.42590599
27IRAK31.39796366
28MARK11.39781546
29TSSK61.34401098
30ACVR1B1.33880709
31STK38L1.32946867
32FGFR21.30085658
33MAPK131.29149518
34LATS11.25007325
35DMPK1.23379131
36MAP2K71.22749342
37PINK11.22473357
38NLK1.19581514
39PLK31.18440097
40CDK31.17174496
41NTRK11.16293900
42NEK61.15333679
43MAP4K21.14039967
44TGFBR11.13942201
45EPHB21.10072930
46SGK31.09639040
47OXSR11.08608724
48SGK2231.07676582
49SGK4941.07676582
50TTK1.07164056
51IRAK21.07118605
52TGFBR21.05582441
53GRK11.05262086
54FES1.03744369
55BRSK21.02621902
56PRKAA21.01728465
57EIF2AK21.00336439
58ZAK0.96765745
59IRAK10.95779994
60CAMK10.94935969
61VRK10.94258492
62CAMK1D0.93134897
63CAMK1G0.89975132
64STK380.89965610
65DYRK20.87663385
66PLK40.85363883
67CSNK1G20.84730273
68CDK190.83635696
69PLK20.83213746
70ADRBK20.82112790
71FER0.81619437
72BMPR1B0.81566390
73VRK20.81061242
74MARK20.79774232
75STK390.76463446
76STK30.74355964
77CDK90.74323615
78PRKCE0.74119870
79MAPK70.73810028
80PRKD10.73228320
81PKN10.72379156
82TEC0.72039496
83PIK3CA0.71327783
84BCR0.69052999
85FGFR10.68096191
86YES10.67927764
87STK110.67422638
88WEE10.67083443
89UHMK10.66480678
90CLK10.66379896
91FGR0.64468498
92MAPKAPK50.63018396
93MAP3K40.62388078
94AKT30.60159778
95FGFR30.58378942
96BUB10.55488134
97CAMK2A0.55482084
98MINK10.55151852
99ROCK10.55020461
100PTK2B0.54479825
101DYRK1A0.54255269
102ADRBK10.53152244
103PLK10.53000394
104SGK10.51893347
105MAPK120.51584164
106WNK10.51533934
107CDK50.50703201
108PRKG10.50340184
109CSNK1G30.49936903
110MAP3K70.49358001
111ATM0.48878903
112PAK30.46944331
113PRKCH0.46869457
114GRK70.45884336
115SIK10.45390089
116CAMK40.45211206
117LATS20.44068863
118PAK60.43838941
119CDC42BPA0.42470212
120PRKDC0.42403242
121CSNK1E0.40593198
122TAOK20.39905602
123PRKACA0.39731004
124SRPK10.38901342
125IGF1R0.37968369
126NEK10.37476103
127PBK0.37376384
128DAPK20.36992942
129ALK0.36511642
130CAMK2B0.35463561
131CSNK1D0.34784804
132MET0.33857770
133CSNK1G10.33760794
134NEK20.33345843
135INSR0.30112785
136RIPK10.29964026
137CAMK2G0.29823557
138OBSCN0.29101459
139RPS6KA30.28857821
140PRKCA0.28729361
141CSNK1A10.28674521
142PRKCQ0.28031172
143MAP2K40.27710068
144JAK10.26834054
145ERBB20.25186847
146PRKCG0.24840925
147CSNK1A1L0.24498608

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.01731526
2Fatty acid biosynthesis_Homo sapiens_hsa000613.21443476
3Nicotine addiction_Homo sapiens_hsa050332.76116541
4Glutamatergic synapse_Homo sapiens_hsa047242.39230179
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21777915
6Non-homologous end-joining_Homo sapiens_hsa034502.02737664
7Propanoate metabolism_Homo sapiens_hsa006402.01032585
8Morphine addiction_Homo sapiens_hsa050321.99979587
9Circadian entrainment_Homo sapiens_hsa047131.95773603
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88769514
11Salivary secretion_Homo sapiens_hsa049701.85275401
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76408702
13Dorso-ventral axis formation_Homo sapiens_hsa043201.76263007
14GABAergic synapse_Homo sapiens_hsa047271.75387413
15beta-Alanine metabolism_Homo sapiens_hsa004101.73988647
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64834329
17Circadian rhythm_Homo sapiens_hsa047101.62200549
18Calcium signaling pathway_Homo sapiens_hsa040201.53840368
19Gastric acid secretion_Homo sapiens_hsa049711.53124939
20Axon guidance_Homo sapiens_hsa043601.50850879
21Long-term depression_Homo sapiens_hsa047301.47881599
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45832269
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44612620
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44315721
25Taste transduction_Homo sapiens_hsa047421.42321944
26cAMP signaling pathway_Homo sapiens_hsa040241.41511254
27Basal cell carcinoma_Homo sapiens_hsa052171.41142571
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39581222
29Insulin secretion_Homo sapiens_hsa049111.39330077
30Renin secretion_Homo sapiens_hsa049241.38285397
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37947592
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.29175911
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26849859
34Melanogenesis_Homo sapiens_hsa049161.26029850
35Long-term potentiation_Homo sapiens_hsa047201.25854671
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.24474611
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22928385
38Fanconi anemia pathway_Homo sapiens_hsa034601.22909002
39Cholinergic synapse_Homo sapiens_hsa047251.22639233
40Rap1 signaling pathway_Homo sapiens_hsa040151.22041497
41ECM-receptor interaction_Homo sapiens_hsa045121.20956063
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20683937
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20660321
44Selenocompound metabolism_Homo sapiens_hsa004501.17279252
45Dilated cardiomyopathy_Homo sapiens_hsa054141.15307633
46Serotonergic synapse_Homo sapiens_hsa047261.12285854
47Olfactory transduction_Homo sapiens_hsa047401.10821313
48Wnt signaling pathway_Homo sapiens_hsa043101.08698588
49Ras signaling pathway_Homo sapiens_hsa040141.07094386
50Amphetamine addiction_Homo sapiens_hsa050311.06697207
51Adherens junction_Homo sapiens_hsa045201.05335735
52Histidine metabolism_Homo sapiens_hsa003401.05299318
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02142316
54Oxytocin signaling pathway_Homo sapiens_hsa049211.01887582
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.01444999
56RNA degradation_Homo sapiens_hsa030181.01096598
57Mismatch repair_Homo sapiens_hsa034301.00234669
58Gap junction_Homo sapiens_hsa045400.99642489
59Homologous recombination_Homo sapiens_hsa034400.99239914
60Fatty acid metabolism_Homo sapiens_hsa012120.98419355
61African trypanosomiasis_Homo sapiens_hsa051430.98020852
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97848821
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96505990
64Pancreatic secretion_Homo sapiens_hsa049720.95930768
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95927120
66RNA polymerase_Homo sapiens_hsa030200.95054748
67Butanoate metabolism_Homo sapiens_hsa006500.94691285
68Linoleic acid metabolism_Homo sapiens_hsa005910.94450638
69GnRH signaling pathway_Homo sapiens_hsa049120.93931891
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92591821
71Phototransduction_Homo sapiens_hsa047440.91880259
72Cocaine addiction_Homo sapiens_hsa050300.87149064
73Lysine degradation_Homo sapiens_hsa003100.86522132
74Choline metabolism in cancer_Homo sapiens_hsa052310.85801774
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85333255
76Sphingolipid metabolism_Homo sapiens_hsa006000.85095082
77Melanoma_Homo sapiens_hsa052180.84783864
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84726566
79Vitamin B6 metabolism_Homo sapiens_hsa007500.84209387
80Tryptophan metabolism_Homo sapiens_hsa003800.83925005
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83886161
82Basal transcription factors_Homo sapiens_hsa030220.83344406
83Mineral absorption_Homo sapiens_hsa049780.82443355
84Focal adhesion_Homo sapiens_hsa045100.82352838
85Dopaminergic synapse_Homo sapiens_hsa047280.82253416
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82022450
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81305218
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80458967
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79217138
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79017204
91Oocyte meiosis_Homo sapiens_hsa041140.78958211
92Ovarian steroidogenesis_Homo sapiens_hsa049130.78427850
93PPAR signaling pathway_Homo sapiens_hsa033200.76828140
94Hedgehog signaling pathway_Homo sapiens_hsa043400.75022528
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74618696
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74230470
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73177936
98Glycerolipid metabolism_Homo sapiens_hsa005610.65998845
99Malaria_Homo sapiens_hsa051440.65848050
100Fatty acid degradation_Homo sapiens_hsa000710.64745325
101Pyruvate metabolism_Homo sapiens_hsa006200.64200920
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63313245
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63079791
104MAPK signaling pathway_Homo sapiens_hsa040100.62319036
105Purine metabolism_Homo sapiens_hsa002300.61625585
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61496220
107Ether lipid metabolism_Homo sapiens_hsa005650.60788293
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.60608513
109Arginine and proline metabolism_Homo sapiens_hsa003300.60247205
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59862057
111Cardiac muscle contraction_Homo sapiens_hsa042600.58751587
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57590716
113TGF-beta signaling pathway_Homo sapiens_hsa043500.56581018
114Pathways in cancer_Homo sapiens_hsa052000.56313918
115Hippo signaling pathway_Homo sapiens_hsa043900.53794324
116Vitamin digestion and absorption_Homo sapiens_hsa049770.53497355
117Bile secretion_Homo sapiens_hsa049760.52515619
118RNA transport_Homo sapiens_hsa030130.51973421
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51617318
120Retinol metabolism_Homo sapiens_hsa008300.51324457
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51236721
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.51080564
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49589006
124Proteoglycans in cancer_Homo sapiens_hsa052050.49575073
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49561429
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48984133
127Tight junction_Homo sapiens_hsa045300.48335385
128Notch signaling pathway_Homo sapiens_hsa043300.46377023
129Protein digestion and absorption_Homo sapiens_hsa049740.46013919
130Thyroid hormone synthesis_Homo sapiens_hsa049180.45991861
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.45300403
132Glucagon signaling pathway_Homo sapiens_hsa049220.45205362
133ErbB signaling pathway_Homo sapiens_hsa040120.44915590
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44304048
135Estrogen signaling pathway_Homo sapiens_hsa049150.44220709
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44210646
137Glioma_Homo sapiens_hsa052140.42787148
138Alcoholism_Homo sapiens_hsa050340.42001606

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